LOCUS       gnlProkkaIGNKILOI_45   13724 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IGNKILOI_45.
ACCESSION   gnlProkkaIGNKILOI_45
VERSION     gnlProkkaIGNKILOI_45
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 11:09:36
            Original ID  :: gnl|Prokka|IGNKILOI_45
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 268918
            Orig. end    :: 282642
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13724
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13724
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13724
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2152..3162
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_191"
                     /sec_met_domain="PF04055 (E-value: 2.7e-17, bitscore: 57.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDDMTNLSLKH
                     RELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGC
                     KMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALE
                     LLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAF
                     SITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAI
                     PGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
     CDS             3181..4221
                     /locus_tag="ctg45_192"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             4226..5320
                     /locus_tag="ctg45_193"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQANFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5330..6571
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg45_194"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6558..7085
                     /locus_tag="ctg45_195"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7091..7864
                     /locus_tag="ctg45_196"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             7871..8266
                     /locus_tag="ctg45_197"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             8515..9903
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg45_198"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_199"
                     /sec_met_domain="PqqD_RRE (E-value: 1.5e-10, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.5e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(10370..10654)
                     /locus_tag="ctg45_200"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10692..11759)
                     /locus_tag="ctg45_201"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVSKKVAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKELNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(11832..13343)
                     /locus_tag="ctg45_202"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
ORIGIN
        1 acgttcattt ccagttgaat ggtttttcac aagtggatgc taaggagttc tcaaaacaat
       61 atttgtctgc ttactccaag accttgtctg cacagcagga agatattctt ggttcgtggg
      121 tgctggctaa acaaccgcgc tgtttaagtg tattgctcaa tgagctggtt tcgttcggtc
      181 agtacgatgc tctctatgaa tatatgagtg gatattgccg gctcaatgag gttgagcaat
      241 tttatgacag tgtgcttcgg cgtttgtcgg ctgattatgg tttcgaagag attggaagaa
      301 cgcttctgat gctttcactt actttagaag gatttaccga agatgaagta aagagcatgg
      361 caggcataaa tcagatgctt tggtcacagt tgaaagtgga aatgagtagc tggctcacca
      421 acaaaggagg gcgatattgt atttgtgaca cacaaatggt agaggcgatt aaacgatgct
      481 tcgctcaagg cgatatgtgc atcgataagt gtcgtcataa aataataacc tctcttctgg
      541 acaatgaaga tatcctttcg caccaactga cttttgctga ttatagctat cgtatgaaac
      601 agttctgcta ccatgattct tatcgctata aagtggaaat tacttatcaa ggttataaga
      661 tgcaggagcg gaatttcttg agaaagtgga tttgtgatgt agaactcttc gaaattctgt
      721 atcgtacgaa ttattctttg ttggaagatt gctggaaggc acttatgagc gacgactctt
      781 cttttatgcc tgatgtctat gccgaatcgg actttggtca ggttgattct tttttgattc
      841 ctgtcattgc taatgatata gctactttct taagtcgttc ttttcacctg acaaaggtag
      901 caaatgttgt gagtgagaaa tgtatggaag gagctgccat accgccaatt gccagatcag
      961 tgctgaaaat gaacgaggga tgtcgctatg cccgtgacga agaatatgaa atggcatgtg
     1021 attgtttcct gaaagcattg atgatgcagg aaaatatagt accgattccg gtaccccaga
     1081 ttactgatac atgtaggaat ttggggatgg catgttatta taatgggcaa tataatgaag
     1141 cggtgactta tctaaataga gcgcttggct atcatgcggc ttctactgac gagaataata
     1201 tggcagaaat cattgaactt tacgaactgc tggcttattg cgattattat aagaaaaacg
     1261 aagagagtgc ggccgaacaa ttccggaaag tagctaaaat gcacgaatct ttgaatggta
     1321 gattgtcaag tggagtggct aaatgcatgc gtatgcaagg tagatgtctt tattgtgtta
     1381 agcaatacga tgaagcgtgg aatctgatga atcgggcatt ggatatttct atgcagatag
     1441 ataatagaaa gcagatagtc gcttgtcata aacagttgta ttatctatgc atagaattca
     1501 aacgcataat gaatgagcgt aacgatgagc aggccgctac tttattcttc catgagtctc
     1561 ttctgcatga agtgtttttc agcgaaaagc ctcgtttggc agaattgact atccgttacg
     1621 aggcattaag atgtgatatt atgcagcaat attacatgaa taaagattat gataatgtga
     1681 ttcgtatagc aacctccctg gatattcatg atgatggtga ccccgattct tcctgtctgg
     1741 tatattacta caaagcactg gcttatacga aaaagaagga ttatccaatg gcgaaagcgg
     1801 ctttcttcaa agagtttgaa ctgcgaaaga agcatcaggg atgggagaat gaagatacga
     1861 ttgtggcttg tcaaaactta ggggttttac acaaatattg ttatgaacgg aaagatgcgc
     1921 tggcttgttt ccgtgaggcg tatggtcacg aagtgaaacg gaatggcgag gactctgaat
     1981 tggcgcgaac gctacttcaa tatatcagct ttgttaaata ataacttggg tatacttccc
     2041 ttttttgtta acttttacat tcctgctata cggaaatcga ctttatttcc ttacatttgc
     2101 agatataaac tatcaacaga aagaagaatg tctaaatatc cccttttagg aatgactctt
     2161 gtagagcttc aatcattgac aaaaagactg ggtatgcccg gctttgctgc caagcagatt
     2221 gcatcctggc tttacgaaaa gaaggtagcc tcgattgatg atatgactaa tttgtcattg
     2281 aaacaccggg agttgctcaa gcagaactat gaggtgggag cggaagctcc ggtagatgaa
     2341 atgcgctctg tagatggtac ggtgaagtat ctttataaag tgggtgagaa ccattttgta
     2401 gagtcggttt atataccgga tgatgaccgg gcaacgttgt gcgtgtcgtc acaagtaggt
     2461 tgcaagatga actgtaagtt ctgtatgacc ggcaaacagg ggtatacggc taacctgacc
     2521 gccagccaga tcataaacca gattcattcg ctgccggaac gggacaaact gactaatgtc
     2581 gtaatgatgg gaatgggcga gccgctcgat aacctggatg aggtattgaa ggcattggaa
     2641 ctactgaccg ctacctacgg ttacgcatgg agtccgaagc gtatcacgct ttctacagtc
     2701 gggctacgga aaggattgca gcgttttatt gaagaaaatg actgccacct tgccatcagc
     2761 cttcactctc cgctgaccgt tcagcgtgct gaattaatgc cggcggaaaa ggcgttttca
     2821 atcaccgaaa tggtggaact gttaaaaaac tatgatttta gtaaacaacg tcgactttcg
     2881 tttgaatata ttgtttttaa agggctcaat gattcgcagg tctatgccaa agagttgctg
     2941 aaacttcttc gcgggctgga ttgcagggtg aatctgattc gttttcatgc cataccgggg
     3001 gtagacctcg agggggcgga catggatacg atgacccgtt ttcgtgatta tctgacgtca
     3061 cacggacttt tcaccactat ccgttcatcc aggggcgaag atatttttgc cgcttgcggt
     3121 atgctgtcga cagcgaaaca ggagaaaaat aatgaaagtt aatatataaa accgaacatc
     3181 atgaaaaagt actcttttat tttatgcatc gctttggtag cctttgtcgt tgcatcttgt
     3241 ggtctgaaag gaaatcacac ctctagtggt cgtgcttacg agcttttggt tgtagtagat
     3301 cacggtgttt gggatcgtgc tgccggaagg gctttacatg atgcgctcga tgctgatatg
     3361 cccggtttgc cgcagtcgga accttctttc cggattatgt atacttcgcc gaaagattat
     3421 gattctacgc tgaagttgat acgtaacatt attattgtag atatacagga tatatatacg
     3481 aaagcctcgt tcaaatatgc gaaggacgtg tatgccaatc cgcagatgat attgactatc
     3541 caggctccga acgaagaaga gttcgagaag tttgtggaag agaacaaaaa gacgattgtc
     3601 gacttcttta cccgtgcgga aatgaaccgt cagattacat tcctggaagg gaaacacagt
     3661 aatttcattt cgcagaaagt ggacagtttg ttcggatgcg acatctgggt ggatgccgaa
     3721 ctggctaatt caaagaccgg ggatgatttc ttctgggctt ctaccaacac aggtactgcc
     3781 gaccgtaact ttgtgatgta ctcttatccg tacactgaca aggatacgtt taccaaagaa
     3841 tattttgtgc acaaacgtga ctctgtgatg aaagccaata tccccggatt caaggaagga
     3901 gtttatatgt cgaccgatag tttactgacc gatgtccgtc cgatcaatgt acagaacagc
     3961 tacacaatgg aagcacgtgg tctgtggcgt atgaagggcg actttatggg tggtccgtat
     4021 gtatctcata ctcgtctgga cgagaagaac caacgaatta ttactgcaga aatatttgtt
     4081 tattcacctg ataaaatgaa acgcaaccta gtacgccaga tggaagcatc tctgtataca
     4141 ctgaaacttc cgaatgaagt tcagcagaag cagattccat tgggagaagc atctaaggaa
     4201 gcggaacaaa ctaataaata aaaacatgga agataacaag ataaggatag gtatcaccca
     4261 aggagatatt aacggggtgg gctatgaggt gattcttaag acattttccg accctacgat
     4321 gttggaacta tgtactccga tcatttatgg ctcaccgaaa gtagcggctt atcatcgcaa
     4381 agcactggat atacaggcca atttcagcat tgtcaactct gctaccgaag cggggtacaa
     4441 ccgtttgagc gtggtgaact gtacggatga tgaggtgaaa gtggaatttt ccaaacccga
     4501 ccccgaagcc ggtaaagctg cgctgggggc tttggaacgt gccatcgaag aatatcgcga
     4561 agggttgata gacgttatcg taacagctcc gatcaacaaa catacgattc agtcggaaga
     4621 gttctccttc cccggacata cggaatatat cgaagaacgt ctgggcaatg gtgataagtc
     4681 attgatgatt ttgatgaaga atgacttccg ggtggctttg gtgacgacac atatccctgt
     4741 tagagagatt gcgactacga ttaccaaaga attgattcag gagaaactga tgatattcca
     4801 tcgttgtctg aaacaggatt tcggtatcgg cgctccgcgt attgcggtgc tctctctcaa
     4861 tcctcatgcc ggagacggtg gtttgttggg aatggaagag caggaagtga ttatccctgc
     4921 catgaaagaa atggaagaga aaggaatcct ttgctacggt ccttatgcgg ccgacggctt
     4981 tatgggttcg ggcaattata ctcattttga cggtatcctg gcgatgtatc acgatcaagg
     5041 gctggctccg ttcaaggcct tggctatgga agacggggtg aactatacgg caggactgcc
     5101 ggtagtacgt acttctccgg ctcatggaac ggcatacgat attgcaggca agggagtggc
     5161 ttgtgaagat tctttccgtc aggcaatcta tgttgccatc gacgtgttcc gtaatcgtca
     5221 gcgggaaaaa gtggctcgtg ccaatccgtt gcgtaaacag tattacgaga aacgtgacga
     5281 tagtgataaa ctgaagctgg atacagtaga cgaagattaa aaacgagtga tgacgaaagc
     5341 agagatacaa caagtgaaac agcgtttcgg tattattgga aatactgaag cattgtcgcg
     5401 cgccatagat gttgccattc aggtagctcc taccgatttg tctgtgctga ttaccggaga
     5461 aagtggagtc ggaaaagaaa gttttccgca gattattcat caatatagcc ggaggaagca
     5521 cggacagtat attgctgtca actgtggcgc tattccggaa ggtacgattg attccgaact
     5581 gttcggacat gagaaaggtg cgtttaccgg tgcgattggc gaacggaaag ggtactttgg
     5641 cgaagctgac ggtggtacta tttttcttga tgaagtaggg gagttgccga tgtctaccca
     5701 ggcacgtttg ctccgtgtac tggagagtgg cgagtttatg aaagtaggtt cgtccaaagt
     5761 acaaaaaacg gatgtgcgtg tggtggcggc taccaacgtc aatcttacac aagcgattgc
     5821 agaaggacgt ttccgtgaag atttatatta ccggttgaat acggtgccta tccagatacc
     5881 gcctttgcgt gaacgtggtg acgatgtact tttgttgttt cgtaagtttt ccgcagactt
     5941 tgcagagaaa taccggatgc ccgctattca gttgacggag gatgcgaaga aagagttgtt
     6001 ggcttacccg tggcccggaa acgtgcgtca gttgaagaac atcaccgagc aaatatctat
     6061 cattgaaacc aatagggaga tctctgctgc tatcttgcag aattatcttc ctgcacaaaa
     6121 tacgcaacgt cttcccgcgt tgatgggaac gcgtgagagt aaaggctttg agagcgaacg
     6181 ggagattctt tattctgttc tgttcgatat gcgccaggaa gtggcggagc tgaagaagat
     6241 ggtgcacaac ctgatggcgg aacgtgccgg acaggtgggg caggtaggac aaatgggaac
     6301 ggtggttact actccggtag tgacggcgca tcaaccttcg gtacctgcta tcattcacac
     6361 catgcagcct acggtttgca aggatgatga tgacatacaa gacacggaag aatatgtaga
     6421 agaatcccct ttgtcactgg acgaagtgga gaaagaaatg atacgcaagg cacttgagag
     6481 gcatcatgga aagcggaaga gtgcggccaa ggacttgaat atttccgagc gtacacttta
     6541 tagaaaaata aaagaatatg aattggatta agaaaataat acgccctttg ttactgttcg
     6601 gcttgccgtt ggtagtcatt gcgtgcactg tttcctataa gtttaacgga tcgtctatca
     6661 attatgataa ggtaaagacc atttcgatag ccgacttccc gatcaagtcg gagtatgtat
     6721 atgctccgtt agcaaccaaa ttcaatgagg acctgaaaga tatcttcatc cggcagaccc
     6781 gtctgcaact gctcaagccg aatcagaatg cggacttgca gattgacgga gaaatcacag
     6841 gatacaatca gtacaaccag gcagtatctg ccgacggtta ctcttcggag acgaagttga
     6901 ctattaccgt caatgtacgt tttgtcaaca acaccaatca tgccgaagac tttgaacaac
     6961 agttttctgc gttccgtacc tacgactcta gccagttgct gactgccgta caggacggat
     7021 tgattgctga aatgtctaaa gagatcaccg accaaatttt taatgcaact gtagcaaact
     7081 ggtaatataa atgacttctg ttaactttca acaatggatt cagcatcccg agacgctgaa
     7141 tagggatact ttgtacgaac tgcgcaatct tcttgcgagg tatccgtatt ttcagtcact
     7201 tcgtctgctg tatctgaaga atctgtatat tctccatgat attagtttcg gtggagaact
     7261 gcggaaagca gttctttaca ttgcagacag acggcagttg ttccggttga ttgaaggtga
     7321 ccgctatgat gtgcaggcac ggaaaaaggg agtacctctc acggaggtgc tgaaagacga
     7381 accgtccgta gaccgcacat tagcattgat cgacgctttc ttgtccacag tacccgaaga
     7441 ggtgactgcc cgcaccagct tcgactattc gatggattac acctcttatc ttttggagga
     7501 gactccggcc acggaacagt cggccgaaga aacgcccaaa ctcaaaggct acgaactgat
     7561 tgacgacttt atagaaaaga gcgagagcga ctctcccctc tgcaagaaac ctttaagaga
     7621 agaaatgcca tcttcgccaa cctcttcgga cgaacttacc gaagaagaaa cgatgaagga
     7681 agaagaggaa gatgacagct gttttacgga aactttggca aaaatctatg ttaaacagca
     7741 acgatattca aaagctcttg aaataattaa aaaattaagc ttgaaatatc caaaaaaaaa
     7801 tgcttacttt gcagaccaaa tcagattttt ggagaaattg attattaacg ctaattcaaa
     7861 ataactaaaa atgtacttat tattcgttat cttaatggtt attgcagcct tgttgatgtg
     7921 tttcatcgtg ctgattcaga actcaaaagg aggcggactt gcttctggtt tctcttcatc
     7981 taacgccatc atgggcgtgc gcaagactac agattttctg gaaaaagcaa catggggctt
     8041 agctatcttc atggtggtaa tgagcattgc tactgcttat gtagttcctc gctctgctgt
     8101 tgctaaagac gcagtgttgg aacaggcaca gaaagaacaa cagactaacc cgtataactt
     8161 acccgcaggt acggctgcgc cgcaaactga agctcctgct accaatgcac ctgctacaga
     8221 aactccggca cctgctactg aaactcctgc tcctgcagca gagtaattca ctccgttgtc
     8281 aggtaagact ttggggtaaa accattaatg ggaaggtgca gacggatgct gcatttcttt
     8341 gatatttaag tgcggattac gcagattaca cggattttca atcttccgcg tggtcagtgt
     8401 aatccgcact taactttttc ttgtaaaaac aatctctttt tgatagaaac aaacgagatt
     8461 taactacctt tgttggtcgt atgaagatta ttaactactt ttttaaatat aacaatgaca
     8521 gaacatttga aacagaaatt gaatgactcc gccgtactcc gatggagtgt tctagcattg
     8581 gtcgcattta ctatgctatg cggctatttc ctcaccgacg taatgtctcc tctaaaaccc
     8641 atgcttgaga aagaactact atgggacagt cttgattatg gtttcttcac aagcgcttac
     8701 gggtggttta atgtattcct attgatgctg attttcggtg gtatcatttt ggataagatg
     8761 ggagttcgtt tcaccggaat gggggcttgc ttattgatgg tgtttggttg tggattgaaa
     8821 tactatgcga tttctactac ttttccggaa ggtgccatgc tctttggatt caaaacacag
     8881 gtaaccctgg ccgcattggg gtatgctatc ttcggtgtag gtgtggaaat tgccggtatc
     8941 acagtttcca aaattatcgt aaaatggttc aagggtaagg aaatggcatt ggctatggga
     9001 cttgaaatgg ctacggcacg tatcggaaca actctggcaa tggtgctcac ggttcctttg
     9061 gccgactttt tcggatctac ggatgagagt ggcacattcc ataccaatat tcctgctccg
     9121 attttgtttt gtctgattat gttgtgcgtg ggtacgattg ctttcttcct ttatactttc
     9181 tatgataaga agttggatgc ttctttggat gcagagggat tggagccgga agagccgttc
     9241 cgtatgaaag atattgtgta tatcattacg aataagggat tctggctgat tgcattacta
     9301 tgtgtattgt tctactcggc tgtattcccc tttatcaagt atgctgccga cttgatggtg
     9361 cagaagtata atgtagatcc gaagttggcg ggaacgattc ccggattgtt gccgattggt
     9421 gcgattattc tgactccgtt gttcggctcg ctttatgacc gtattggtaa gggagccaca
     9481 ttgatgataa tcggatcagt gatgcttatt tttgtgcata cgatgtttgc tctgcctata
     9541 ctgaatatat ggtggtttgc tactattatc atgattatat tgggatttgc cttctcgttg
     9601 gtgccttcag ctatgtggcc gtctgttccg aagattattc cggaaaaaca gttgggtacc
     9661 gcatacgcat tgattttctg ggtacagaac tggggattga tgggtgttcc tttgttgatc
     9721 ggatgggtgt tgaatactta ttgcaaaggt ccggtagtag acggtgcaca gacttatgac
     9781 tacacgttgc cgatgactat ttttgctctt tttggtgtac ttgctctgat tgtggctttg
     9841 atgttaaagg cagagaacaa gaagaaggga tacggtctgg aagaggcgaa tattcaaaag
     9901 taactgggaa attcaatacc taaagtaaca aaggaatttt gtatcaaggt gtaaacaaaa
     9961 gggtatcagt atgaatactc tgaaataaaa aataagaagt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacaattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtgcc
    10141 gaaaggaatg tcgaaagaac ttcatgtgaa attggaagaa cacggtacgg ctgtatggga
    10201 actgatagat ggaaaacgca atgttcgtga gattatagaa aaactcgcag accactttca
    10261 aaatgaagag ggctacgagt cgcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 atttataaaa ctggtgatac cagttgcata aataggaatt tattattatt tatttgataa
    10381 atacagccca aagtatgacg gcaattgcta tcaggacccc catgataata agcgttcccc
    10441 aaacaaaata attgctgtct ttctctttct ttttctccga gtcgtggatg atacgttcca
    10501 tttcttcggg ggtggtgttg ggtagtggat aaggttcgtt tgcacggttt agatgcttca
    10561 acttatcgtt agcacgttca cgacgtaggc gggaagcttc ccgtccctct tttattcggc
    10621 gtatcatgtc gaatgcatgt ccttcaccaa ccatattctt tgttttttag aagttcactt
    10681 ccttcgtttt tctatttccc ttcttctctg tccactttga gcaatcctcc cgtattcgga
    10741 tcaaaataaa ctttgatggt agaattctta ttgaacaaaa ccggagccag atattctatc
    10801 acaccgaatt gagtaatagg aagctcacct tcataaagtt tctttttacc gtcggtcagt
    10861 gtaaccatag cttgtccggg tacgttgtag gcgattccat ccaaatcttt cttcttctta
    10921 ccatcttcct gtggcatctt gaccgatttc aggtctttca gactgatata aaacggagtt
    10981 cctgccaaat cattgttggc aactacacct aacttcttcg agaagcggaa ggcaacttca
    11041 ttgttgagtt ctttgtcagg agtaaggcgg acagtgaatg ttctctcttc tttgttgcag
    11101 gtgccggaga acatttgcgt catggcttct tcctgtgcat tcagattgtc gagcataatc
    11161 ttaagctgtg ctccgtctga aggcatatta tcagcctgtc cgcgcaataa ggcatttttg
    11221 ctttcgcgga tgttatagat ctctttagcc accagctcgg ccatcttggc ggtagaacta
    11281 gccatcagaa tctcttcggt caggaattcg cgaggattcg ctttcttttg gaggactgcg
    11341 ggggcgggag caactttttt gcttacactg ctgttgctgt aaggaacatt gatcgttttc
    11401 acaatgccat cctctgtcag ttccatgagc ggtgctactg tcttatcctt caattttacg
    11461 aaatacgtag tttcgctgtt gggcacacct acggatttca cttttacgct agccagttcc
    11521 cagtactctt cagggtcggc ggagacgttg gtcagtcgta ggtaacgatc agcatatttg
    11581 ctgaattctc cgggagtata gttgactttg ttggctttta tttcaagttc tatttgggtt
    11641 ttgggaagac tgtaaaccac tccatagtct tttcctcggg taacccccgt cagtacttcg
    11701 gtttgtgcat aggcggacgt tgtcataagt agtcctgctg ctataatcaa ctttttcata
    11761 ttcggttctt tttaactggt tttgaaaaca aagttaatga agttattgaa aaaagggtaa
    11821 gttcttaact tttattcgct tacaagtcgc catgctgtcg gcagacaggt gataatatcg
    11881 cttgcgatca ttccgatcat tccttgcttc ttttgagcga catcgcccgc cagtccgtga
    11941 atgtaagtgc cgattttagc ggcttcctcg gtggggtaac cttgggcaag cagtgccagg
    12001 attactccgg tcagtacgtc accgctacct ccggttgcca ttcccggatt tccggttggg
    12061 ttgaagaaac atttaccttc gggggtgata atggcggagt aggctccttt taaaataatg
    12121 tgaacatggg cggcacgggc cagttcgcaa gccttcatca gacgttcgta agagtcctgg
    12181 catttgccgg tcagacgttc cagttctttc ggatgcgggg tgaggatgga acccttcggc
    12241 aggtgggtaa gggcatggcg gtggttggca aggatattaa gtgcgtcggc atccaccaca
    12301 acaggagtct ggcagtgttc cagttgttcc aacaaggcag cttccgtttc ctcgtttcgt
    12361 cccagtcccg gaccgatgcc gactgcttga tagtcgtccg tgtcggtagg tacggcaaaa
    12421 caggtttcgt tgatgtcggt ttctacgatt gcttcgggta tggaggtttg caagatgtcg
    12481 ttgttgcaca ttggtgcatg aacagtcagt aatcctactc ccgaacggag gcaggcgcgg
    12541 gcagcgagaa cagaggctcc tgccattcct tttgaaccgg caatcaatag tgcatggccg
    12601 aagttcccct tgtgggcaaa ctgtttgcgt ggcttgatga gtgaacggat ttgctctatt
    12661 tccaacattt cgtagttagt ctccatttct tcaataccgt cttcgctcaa ttggatatcc
    12721 agcacttccc attctccgac aaattccgtg ttctctgcga aaagaaaggc gagcttcggc
    12781 agttgaagac tgaaagttac gtcggcacgg ataatattag cttttacgtt gaatgtgttt
    12841 tcttctccca tcagtccgga aggaatgtcg atggctacta ccatggcagg ggaggaattg
    12901 atgtatttca ctacggcagc gaatccgccg ctcaacggtt tgttcaggcc tgaaccgaat
    12961 aatccgtcga ttaccagatg gtcgggcgtc agggcgggag gtacgaattg ggtactgatc
    13021 tcgtggaatt ttacttcttc catcatttct accagttctt tattggtctg gcagtcgggt
    13081 gaaagttctc ctttcgtgtt gaagagaaat acctcgattt tatatccttt ttcagccatc
    13141 atgcgggcta cggcgagagc gtctccgcca ttattccccg gtccggcaaa gatagtgacc
    13201 ggcgtttccg tattccatct gtctgtgatg gcttttgtta atacggttgc tgcacgttcc
    13261 atcagatcga ttgatgcaat aggttcgttc tcaatggtat aagcgtccaa tttcttgata
    13321 ctgctgcttg gaaatatttt cattgcgatg ttcttttagt tttcggatta caaatgtaca
    13381 tgattcttct gacttttccc gtttgttgtg ggaagaaaac cataattgca acttttaatt
    13441 catcattagt tctatctttg ggtcagagaa atatctgctt ttgaactatt aagtgttaga
    13501 ataactccgc caaaaaataa ttcaatgcag caccattatg aacttacttt tatttctcct
    13561 gaaaaagatt tctggttctt cgtcaaattt ggtggtaatc tcttttttat ttcgacggtt
    13621 tccctcttct tctttcttaa tcctataaaa agttgtagat atgtttgctt tttagtaact
    13681 ttaaagacac cacatcatta agagttacaa tgcaacaagt cata
//
