LOCUS       gnlProkkaIGIHNNAB_71   15285 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IGIHNNAB_71.
ACCESSION   gnlProkkaIGIHNNAB_71
VERSION     gnlProkkaIGIHNNAB_71
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 16:07:48
            Original ID  :: gnl|Prokka|IGIHNNAB_71
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15285
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15285
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4934:5285]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4935..5285
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15285
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15285
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(55..1224)
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 101.3; E-value: 1.4e-30)"
                     /gene_kind="other"
                     /locus_tag="ctg71_1"
                     /transl_table=11
                     /translation="MKSTFSVIYYLKRQVVKKDGTVPVMGRITVDGSQTQFSCKLTIDP
                     KLWDTKGGRVTGRSTAALETNRMLDKMRVRINKHYQEIMERDNFVTAEKVKNAFLGLEH
                     RYHTLMQVFQQHNEDYAKQVEAGMKAKGTLLKYKTVYKHLQEFLNIRYHVKDIALKELT
                     PAFISDFEMFLRTDKHCCTNTVWLYVCPLRTMVFIAINNEWLTRDPFREYEIKKEETTR
                     SFLTKDEIRLLMEGKLKNAKQELYRDLYLFCAFTGLSFADMRNLTEENIRTYFDEHEWI
                     NINRQKTGVVSNIRLLDIAKQIIDKYRGLCENGRIFPVPHYNTCLAGIRAVAKRCGITK
                     HITWHQSRHTAATTVFLSNGVPIETVSSMLGHKSIKTTQIYASAPRMVA"
     CDS             complement(1388..1516)
                     /locus_tag="ctg71_2"
                     /transl_table=11
                     /translation="MVMDLIYRGFIYAANYSESHYNPRRSQIKTELRYLFVTTLNR"
     CDS             1944..3455
                     /locus_tag="ctg71_3"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPITSIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYST
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWQLVSE"
     CDS             3529..4596
                     /locus_tag="ctg71_4"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVSKKVAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             4632..4916
                     /locus_tag="ctg71_5"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(4935..5285)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_6"
                     /sec_met_domain="PqqD_RRE (E-value: 2.1e-10, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.6e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(5383..6771)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg71_7"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(7020..7415)
                     /locus_tag="ctg71_8"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPAAETPAPAAE"
     CDS             complement(7422..8195)
                     /locus_tag="ctg71_9"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(8201..8728)
                     /locus_tag="ctg71_10"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(8715..9956)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg71_11"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(9966..11060)
                     /locus_tag="ctg71_12"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQANFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(11065..12105)
                     /locus_tag="ctg71_13"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             complement(12124..13134)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg71_14"
                     /sec_met_domain="PF04055 (E-value: 2.7e-17, bitscore: 57.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDDMTNLSLKH
                     RELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGC
                     KMNCKFCMTGKQGYTANLTASQIMNQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALE
                     LLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAF
                     SITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAI
                     PGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
ORIGIN
        1 tgacgatagg attatatcga acccaatcct aacttcttgc taaagaagca tttattaagc
       61 gaccattctg ggcgcactcg cgtatatctg cgttgtcttt atactcttgt gtcccagcat
      121 ggaactgact gtttcgatgg gtacaccgtt ggagaggaac accgtcgtgg ctgccgtatg
      181 gcggctctga tgccacgtga tatgcttggt gatgccgcaa cgcttggcga cggcacggat
      241 tccggcaagg cacgtgttgt agtggggaac agggaaaatc ctgccgtttt cgcacagccc
      301 gcggtatttg tcgatgattt gtttcgcaat gtcaagcagg cggatgttag acaccacgcc
      361 cgtcttctgg cggttgatgt ttatccactc gtgttcatcg aagtaggtgc ggatgttctc
      421 ttccgtcaaa ttgcgcatat cggcgaatga caagcccgtg aaggcgcaga acaggtagag
      481 gtcgcggtat agttcctgtt tggcgttctt cagtttacct tccatcagca ggcggatttc
      541 gtctttggtc aggaaactgc gtgtcgtttc ctccttcttg atttcatact ccctgaacgg
      601 gtcgcgtgtg agccattcgt tgttgatggc gataaacacc atcgtccgaa gtgggcatac
      661 atacagccac acggtattgg tgcagcagtg tttgtccgtg cgcagaaaca tctcgaagtc
      721 ggaaatgaaa gcgggggtaa gctctttcaa cgcgatgtcc ttcacgtggt aacggatgtt
      781 gagaaactct tgcaggtgct tgtaaacggt cttgtacttc aagagtgtgc ctttggcttt
      841 catgcctgct tccacctgct tggcatagtc ctcgttgtgt tgctggaaca cctgcatcag
      901 cgtgtgatag cggtgttcca gtccgagaaa ggcgttcttc accttctctg ccgtgacgaa
      961 gttgtcacgc tccatgattt cctgatagtg cttgttgatg cgcacccgca tcttgtcaag
     1021 catgcggttc gtttcgagtg ccgccgtgct tctgcccgtg acacgtcccc ctttggtgtc
     1081 ccacaacttg ggatcgatgg tcagtttgca actgaattgc gtctggctgc cgtccaccgt
     1141 gatgcgtccc atgacgggaa ccgtcccgtc ttttttcact acctgacgtt tgaggtagta
     1201 aataactgaa aatgtactct tcatcgtcct taattttttt gttcaaaatt agttggtgaa
     1261 gagccctcct ctgatacgca aattgcggaa gaacggcgca atcttttttc gttaccggat
     1321 tttttgcgtg agttgtcagt aactcactaa tccttaaagc cttgtttcgt tattcgtgtc
     1381 catttcgtca cctattgagc gtggttacga acaagtaacg tagctccgtc ttgatttggc
     1441 ttcggcgtgg attgtaatgg ctctcggaat aattggcagc gtaaatgaaa cccctgtaaa
     1501 tcaaatccat taccatattc ttccgcattt cacttttttg tagtaacttt gtacgttgta
     1561 gatatgactt gttgcattgt aactcttaat gatgtggtgt ctttaaagtt actaaaaagc
     1621 aaacatatct acaacttttt ataggattaa gaaagaagaa gagggaaacc gtcgaaataa
     1681 aaaagagatt accaccaaat ttgacgaaga accagaaatc tttttcagga gaaataaaag
     1741 taagttcata atggtgctgc attgaattat tttttggcgg agttattcta acacttaata
     1801 gttcaaaaac agatatttct ctgaccaaaa gatagaacta atgatgaatt aaaagttgca
     1861 attatggttt tcttcccaca acaaacggga aaagtcagaa gaatcatgta catttgtaat
     1921 ccgaaaacta aaagaacatc gcaatgaaaa tatttccaag cagcagtatc aagaaattgg
     1981 acgcttatac cattgagaac gaacctatta catcaatcga tctgatggaa cgtgcagcaa
     2041 ccgtattaac aaaagccatc acagacagat ggaatacgga aacgccggtc actatctttg
     2101 ccggaccggg gaataatggc ggagacgctc tcgccgtagc ccgcatgatg gctgaaaaag
     2161 gatataaaat cgaggtattt ctcttcaaca cgaaaggaga actttcaccc gactgccaaa
     2221 ccaataaaga actggtagaa atgatggaag aagtaaaatt ccacgaaatc agtacccaat
     2281 tcgtacctcc cgtcctgacg cccgaccatc tggtaatcga cggattattc ggttcaggcc
     2341 tgaacaaacc gttaagcggc ggattcgctg ccgtagtgaa atacatcaat tcctcccctg
     2401 ctatggtagt agccatcgac attccttccg gactgatggg agaagaaaac acattcaacg
     2461 taaaagctaa tattatccgt gccgacgtaa ctttcagtct gcaactgccg aagctcgcct
     2521 ttcttttcgc agagaacacg gaatttgtcg gagaatggga agtgctggac atccaattaa
     2581 gcgaagacgg tattgaagag atggaaacga actacgaaat gttggaaata gagcaaatcc
     2641 gttcactcat caagccacgc aaacagtttg cccacaaggg gaacttcggc catgcactat
     2701 tgattgccgg ttcaaaagga atggcaggag cctctgttct cgctgcccgc gcctgcctcc
     2761 gttcgggagt agggttgctg actgtccatg cgccaatgtg caacaacgac atcttgcaaa
     2821 cctccatacc cgaagcaatc gtagaaaccg acatcaacga aacctgtttt gccgtaccta
     2881 ccgacacgga cgactatcaa gcagtcggca tcggcccagg gctgggacga aacgaggaaa
     2941 cggaagctgc tttattggag caactggaac attgccagac tcctgttgtg gtggatgccg
     3001 acgcacttaa tatcctcgcc aaccaccgtc atgcacttac ccacctgccg aagggttcca
     3061 tcctcacccc gcatccgaaa gaactggaac gtctgaccgg caaatgccag gactcttacg
     3121 aacgtctgat gaaggcttgc gaattggctc gtgccgccca tgttcacatt attttaaaag
     3181 gagcctactc cgccattatc accccagaag gtaaatgttt cttcaaccca accggaaatc
     3241 cgggaatggc aaccggaggt agcggtgacg tactgaccgg agtaatcctg gcactgcttg
     3301 cccaaggtta ctcaaccgaa gaagccgcta aaatcggcac ttacattcac ggattggcgg
     3361 gcgatgtcgc tcaaaagaag caaggaatga tcggaatgat cgcaagcgat attatcacct
     3421 gtctgccgac agcatggcaa cttgtaagcg aataaaagtt aagaacttac ccttttttca
     3481 ataacttcat taactttgtt ttcaaaacca gttaaaaaag aaccgaatat gaaaaagttg
     3541 attatagcag caggactact aatgacaacg tccgcctatg cacaaaccga agtactgaca
     3601 ggggttaccc gaggaaaaga ctatggagtg gtttacagtc ttcccaaaac ccaaatagaa
     3661 cttgaaataa aagccaacaa agtcaactat actccgggag aattcagcaa atatgctgat
     3721 cgttacctgc gactgaccaa cgtctccgcc gatcctgaag agtactggga actggctagc
     3781 gtaaaagtga aatccgtagg tgtgcccaac agcgaaacta cgtatttcgt aaaattgaag
     3841 gataagacag tagcaccgct catggaactg acagaggatg gcattgtgaa aacgatcaat
     3901 gttccttaca gcaacagcag tgtaagcaaa aaagttgctc ccgctcccgc agtcctccaa
     3961 aagaaagcga atcctcgcga attcctgacc gaagagattc tgatggctag ttctaccgcc
     4021 aagatggccg agctggtggc taaagagatc tataacatcc gcgaaagcaa aaatgcctta
     4081 ttgcgcggac aagctgataa tatgccttca gatggggcac agcttaaaat tatgctcgac
     4141 aatctgaatg cacaggaaga agccatgaca caaatgttct ccggcacctg caacaaagaa
     4201 gagagaacat tcactgtccg ccttacccct gacaaggaat tcaacaatga agttgctttc
     4261 cgcttctcga agaagttagg tgtagttgcc aacaatgatt tggcaggaac tccgttttat
     4321 atcagtctga aagacctgaa atcggtcaag atgccacagg aagatggtaa gaagaagaaa
     4381 gatttggatg gaatcgccta caacgtaccc ggacaagcta tggttacact gaccgacggt
     4441 aaaaagaaac tttacgaagg tgagcttcct attacccaat tcggtgtgat agaatatctg
     4501 gctccggttt tgttcaacaa gaattctacc atcaaagttt attttgatcc gaatacggga
     4561 ggattgctca aagtggacag agaagaaggg aaatagaaaa acgaggaagt aaacttctaa
     4621 aaaaaaagaa tatggttggt gaaggacatg cattcgacat gatacgccga ataaaagagg
     4681 gacgggaagc ttcccgccta cgtcgtgaac gtgctaacga taagttgaag catctaaacc
     4741 gtgcaaacga accttatcca ctacccaaca ccacccccga agaaatggaa cgtatcatcc
     4801 acgactcgga gaaaaagaaa gagaaagaca gcaattattt tgtttgggga acgcttatta
     4861 tcatgggggt cctgatagca attgccgtca tactttgggc tgtatttatc aaataaataa
     4921 taataagttc ctatttatac gactggtatc accagtttta taaatccatc tttctgcatt
     4981 tgagaaagat aagccgatac acgcgactcg tagccctctt cattttgaaa gtggtctgcg
     5041 agtttttcta taatctcacg aacattgcgt tttccatcta tcagttccca tacagccgta
     5101 ccgtgttctt ccaatttcac atgaagttct ttcgacattc ctttcggcac aaggaagcgt
     5161 tgcatccacg gatatttaaa acggggaaag gagagcacaa ttgtctcccc ttccctttct
     5221 gctgtaatat gttcactgcg acagggaatg acctctaaca ggttgatttt ctctttggca
     5281 gccatacttc ttatttttta tttcagagta ttcatactga tactcttctg tttacacctt
     5341 gatacaaaat tcctttgtca ctttaggtat tgaatttcct agttactttt ggatattcgc
     5401 ctcttccaaa ccgtatccct tcttcttgtt ctctgccttc aacatcaaag ccacaatcag
     5461 agcaagcaca ccaaaaagag caaaaatagt catcggcaac gtgtagtcat aagtctgtgc
     5521 accgtctact accggacctt tgcaataagt attcaacacc catccgatca acaaaggaac
     5581 acccatcaat ccccagttct gtacccagaa aatcaatgcg tatgctgtac ccaactgttt
     5641 ttccggaata atcttcggaa cagacggcca catagctgaa ggcaccaacg agaaggcaaa
     5701 ccccaatata atcatgatga tagtagcaaa ccaccatata ttcagtatag gcagagcaaa
     5761 catcgtatgc acaaaaataa gcatcactga tccgattatc atcaatgtgg ctcccttacc
     5821 aatacggtca taaagcgagc cgaacaacgg agtcagaata atcgcaccaa tcggcaacaa
     5881 tccgggaatc gttcccgcca acttcggatc tacattatac ttctgcacca tcaagtcggc
     5941 agcatacttg ataaagggga atacagccga gtagaacaat acacatagta atgcaatcag
     6001 ccagaatcct ttattggtaa tgatatacac aatatctttc atacggaacg gctcttccgg
     6061 ttccaatccc tctgcatcca aagaagcatc caacttctta tcatagaaag tataaagaaa
     6121 gaaagcaatc gtacccacgc acaacataat cagacaaaac aaaatcggag caggaatatt
     6181 ggtatggaat gtgccactct catccgtaga tccgaaaaag tcggccaaag gaaccgtaag
     6241 caccattgcc agagttgttc cgatacgtgc cgtagccatt tcaagtccca tagccaacgc
     6301 catttcctta cccttgaacc atttcacgat aatcttggaa actgtgatac cggcaatttc
     6361 cacacctaca ccgaagatag cataccccaa tgcagccagg gttacctgtg ttttgaatcc
     6421 gaagagcatg gcaccttccg gaaaagtagt agaaatcgca tagtatttca atccacaacc
     6481 aaacaccatc aataagcaag ctcccattcc ggtgaaacga acccccatct tatccaaaat
     6541 gataccaccg aagatcagca tcaacaggaa tacattaaac catccgtaag cgcttgtgaa
     6601 gaaaccataa tcaagactgt cccatagtag ttctttctca agcatgggtt ttagaggaga
     6661 cattacgtcg gtgaggaaat agccgcatag catagtaaat gcgactaatg ctagaacact
     6721 ccatcggagt acggcggagt cattcaattt ctgtttcaaa tgttctgtca ttgttatatt
     6781 taaaaatagt agttaataat cttatacagc caacaaaggt agttaaatct cgtttgtttc
     6841 tatcacaaag agattgtttt tacaagaaaa agttaagtgc ggattacact gaccacgcgg
     6901 aagattgaaa atccgtgtaa tctgcgtaat ccgcacttaa atatcaaaga aatgcagcat
     6961 ccgtctgcac cttcccatta atggttttac cccaaagtct tacctgacaa cggagtgaat
     7021 tactctgctg caggagcagg agtttcagca gccggtgccg gagtttctgt agcaggtgca
     7081 ttggtagcag gagcttcagt ttgcggcgca gccgtacctg cgggtaagtt atacgggtta
     7141 gtctgttgtt ctttctgtgc ctgttccaac actgcgtctt tagcaacagc agagcgagga
     7201 actacataag cagtagcaat gctcattacc accatgaaga tagctaagcc ccatgttgct
     7261 ttttccagaa aatctgtagt cttgcgcacg cccatgatgg cgttagatga agagaaacca
     7321 gaagcaagtc cgcctccttt tgagttctga atcagcacga tgaaacacat caacaaggct
     7381 gcaataacca ttaagataac gaataataag tacattttta gttattttga attagcgtta
     7441 ataatcaatt tctccaaaaa tctgatttgg tctgcaaagt aagcattttt ttttggatat
     7501 ttcaagctta attttttaat tatttcaaga gcttttgaat atcgttgctg tttaacatag
     7561 atttttgcca aagtttccgt aaaacagctg tcatcttcct cttcttcctt catcgtttct
     7621 tcttcggtaa gttcgtccga agaggttggc gaagatggca tttcttctct taaaggtttc
     7681 ttgcagaggg gagagtcgct ctcgctcttt tctataaagt cgtcaatcag ttcgtagcct
     7741 ttgagtttgg gcgtttcttc ggccgactgt tccgtggccg gagtctcctc caaaagataa
     7801 gaggtgtaat ccatcgaata gtcgaagctg gtgcgggcag tcacctcttc gggtactgtg
     7861 gacaagaaag cgtcgatcaa tgctaatgtg cggtctacgg acggttcgtc tttcaacacc
     7921 tccgtgagag gtactccctt tttccgtgcc tgcacatcat agcggtcacc ttcaatcaac
     7981 cggaacaact gccgtctgtc tgcaatgtaa agaactgctt tccgcagttc tccaccgaaa
     8041 ctaatatcat ggagaatata cagattcttc agatacagca gacgaagtga ctgaaaatac
     8101 ggatacctcg caagaagatt gcgcagttcg tacaaagtat ccctattcag cgtctcggga
     8161 tgctgaatcc attgttgaaa gttaacagaa gtcatttata ttaccagttt gctacagttg
     8221 cattaaaaat ttggtcggtg atctctttag acatttcagc aatcaatccg tcctgtacgg
     8281 cagtcagcaa ctggctagag tcgtaggtac ggaacgcaga aaactgttgt tcaaagtctt
     8341 cggcatgatt ggtgttgttg acaaaacgta cattgacggt aatagtcaac ttcgtctccg
     8401 aagaataacc gtcggcagat actgcctggt tgtactgatt gtaacctgtg atttctccgt
     8461 caatctgcaa gtcggcattc tgattcggct tgagcagttg cagacgggtc tgccggatga
     8521 agatatcttt caggtcctca ttgaatttgg ttgccaacgg agcatataca tactccgact
     8581 tgatcgggaa gtcggctatc gaaatggtct ttaccttatc ataattgata gacgatccgt
     8641 taaacttata ggaaacagtg cacgcaatga ctaccaacgg caagccgaac agtaacaaag
     8701 ggcgtattat tttcttaatc caattcatat tcttttattt ttctataaag tgtacgctcg
     8761 gaaatattca agtccttggc cgcactcttc cgctttccat gatgcctctc aagtgctttg
     8821 cgtatcattt ctttctccac ttcgtccagt gacaaaggag attcttctac atattcttcc
     8881 gtgtcttgta tgtcatcatc atccttgcaa accgtgggct gcatggtgtg aatgatagca
     8941 ggtaccgaag gttgatgcgc cgtcactacc ggagtagtaa ccaccgttcc catttgtcct
     9001 acctgcccca cctgtccggc acgttccgcc atcaggttgt gcaccatctt cttcagctcc
     9061 gccacttcct ggcgcatatc gaacagaaca gaataaagaa tctcccgttc gctctcaaag
     9121 cctttactct cacgcgttcc catcagcgcg ggaagacgtt gcgtattttg tgcgggaaga
     9181 taattctgca agatagcagc agagatctcc ctattggttt caatgataga tatttgctcg
     9241 gtgatgttct tcaactgacg cacgtttccg ggccacgggt aagctaacaa ctctttcttc
     9301 gcatcctccg tcaactgaat agcaggcatc cgatatttct ctgcaaagtc tgcggaaaac
     9361 ttacggaaca acaaaagtac atcgtcacca cgttcacgca aaggcggtat ttggataggc
     9421 accgtattca accggtaata taaatcttca cggaaacgtc cttctgcaat cgcttgtgtc
     9481 agattgacgt tggtagccgc caccacacgc acatccgttt tttgtacttt ggacgaacct
     9541 actttcataa actcgccact ctccagtaca cggagcaaac gtgcctgggt agacatcggc
     9601 aactccccta cttcatcaag aaaaatagta ccaccgtcag cttcgccaaa gtaccctttc
     9661 cgttcgccaa tcgcaccggt aaacgcacct ttctcatgtc cgaacagttc ggaatcaatc
     9721 gtaccttccg gaatagcgcc acagttgaca gcaatatact gtccgtgctt cctccggcta
     9781 tattgatgaa taatctgcgg aaaactttct tttccgactc cactttctcc ggtaatcagc
     9841 acagacaaat cggtaggagc tacctgaatg gcaacatcta tggcgcgcga caatgcttca
     9901 gtatttccaa taataccgaa acgctgtttc acttgttgta tctctgctct cgtcatcact
     9961 cgtttttaat cttcgtctac tgtatccagc ttcagtttat cactatcgtc acgtttctcg
    10021 taatactgtt tacgcaacgg attggcacga gccacttttt cccgctgacg attacggaac
    10081 acgtcgatgg caacatagat tgcctggcgg aaagaatctt cacaagccac tcccttacct
    10141 gcaatatcgt atgccgttcc atgagccgga gaagtacgta ctaccggcag tcctgccgta
    10201 tagttcaccc cgtcttccat agccaaggcc ttaaacggag ccagcccttg atcgtgatac
    10261 atcgccagga taccgtcaaa atgagtataa ttgcctgaac ccataaagcc gtcggccgca
    10321 taaggaccgt agcaaaggat tcctttctct tccatttctt tcatggcagg gataatcact
    10381 tcctgctctt ccattcccaa caaaccaccg tctccggcat gaggattgag agaaagcacc
    10441 gcaatacgcg gagcgccgat accaaaatcc tgtttcagac aacgatggaa tatcatcagt
    10501 ttctcctgaa tcaattcttt ggtaatcgta gtcgcgatct ctctgacagg gatatgtgtc
    10561 gtcaccaaag ccacccggaa gtcattcttc atcaaaatca tcaatgactt atcaccatta
    10621 cccagacgtt cttcgatata ttccgtatgt ccggggaagg agaactcttc cgactgaatc
    10681 gtatgtttgt tgatcggagc tgttacgata acgtctatca acccttcgcg atattcttcg
    10741 atggcacgtt ccaaagcccc caacgcagct ttaccggctt cgggatcggg tttggaaaat
    10801 tccactttca cctcatcatc cgtacagttc accacgctca aacggttgta ccccgcctcg
    10861 gtagcagagt tgacaatgct aaaattggcc tgtatatcca gcgctttgcg atgataagcc
    10921 gctactttcg gtgagccata aatgatcgga gtacatagtt ccaacatcgt agggtcggaa
    10981 aatgtcttaa gaatcacctc atagcccacc ccgttaatat ctccttgggt gatacctatc
    11041 cttatcttgt tatcttccat gtttttattt attagtttgt tccgcttcct tagatgcttc
    11101 tcccaatgga atctgcttct gctgaacttc attcggaagt ttcagtgtat acagagatgc
    11161 ttccatctgg cgtaccaggt tgcgtttcat tttatcaggt gaataaacaa atatttctgc
    11221 tgtaataatt cgttggtttt tctcgtccaa acgagtgtga gagacatacg gaccacccat
    11281 aaagtcgccc ttcatacgcc acaggccacg tgcttccatt gtgtagctgt tctgcacatt
    11341 gatcggacgg acatcggtca gcaaactatc ggtcgacata taaacgcctt ccttgaatcc
    11401 ggggatattg gctttcatca cagagtcacg tttgtgcaca aaatattctt tggtaaacgt
    11461 atccttgtca gtgtacggat aagagtacat cacaaagtta cggtcggcag tacctgtgtt
    11521 ggtagaagcc cagaagaaat catccccggt ctttgaatta gccagttcgg catccaccca
    11581 gatgtcgcat ccgaacaaac tgtccacttt ctgcgaaatg aagttactgt gtttcccttc
    11641 caggaacgta atctgacggt tcatttccgc acgggtaaag aagtcgacaa tcgtcttttt
    11701 gttctcttcc acaaacttct cgaactcttc ttcgttcgga gcctggatag tcaatatcat
    11761 ctgcggattg gcatacacgt ccttcgcata tttgaacgag gctttcgtat atatatcctg
    11821 tatatctaca ataataatgt tacgtatcaa cttcagcgta gaatcataat ctttcggtga
    11881 agtatacata atccggaaag aaggttccga ctgcggcaaa ccgggcatat cagcatcgag
    11941 cgcatcatgt aaagcccttc cggcagcacg atcccaaaca ccgtgatcta ctacaaccaa
    12001 aagctcgtaa gcacgaccac tagaggtgtg atttcctttc agaccacaag atgcaacgac
    12061 aaaggctacc aaagcgatgc ataaaataaa agagtacttt ttcatgatgt tcggttttat
    12121 atattaactt tcattatttt tctcctgttt cgctgtcgac agcataccgc aagcggcaaa
    12181 aatatcttcg cctctggatg aacggatagt ggtgaaaagt ccgtgtgacg tcagataatc
    12241 acgaaaacgg gtcatcgtat ccatgtccgc cccctcaagg tctacccccg gtatggcatg
    12301 aaaacgaatc agattcaccc tgcaatccag cccgcgaaga agtttcagca actctttggc
    12361 atagacctgc gaatcattga gccctttaaa aacaatatat tcaaacgaaa gtcgacgttg
    12421 tttactaaaa tcatagtttt ttaacagttc caccatttcg gtgattgaaa acgccttttc
    12481 cgccggcatt aattcagcac gctgaacggt cagcggagag tgaaggctga tggcaaggtg
    12541 gcagtcattt tcttcgataa aacgctgcaa tcctttccgt agcccgacag tagaaagcgt
    12601 gatacgcttc ggactccatg cgtaaccgta ggtagcggtc agtagttcca atgccttcaa
    12661 tacctcatcc aggttatcga gcggctcgcc cattcccatc attacgacat tagtcagttt
    12721 gtcccgttcc ggcagcgaat gaatctggtt catgatctgg ctggcggtca ggttagccgt
    12781 atacccctgt ttgccggtca tacagaactt acagttcatt ttgcaaccta cttgtgacga
    12841 cacgcacaac gttgcccggt catcatccgg tatataaacc gactctacaa aatggttctc
    12901 acccacttta taaagatact tcaccgtacc atctacagag cgcatttcat ctaccggagc
    12961 ttccgctccc acctcatagt tctgcttgag caactcccgg tgtttcaatg acaaattagt
    13021 catatcatca atcgaggcta ccttcttttc gtaaagccag gatgcaatct gcttggcagc
    13081 aaagccgggc atacccagtc tttttgtcaa tgattgaagc tctacaagag tcattcctaa
    13141 aaggggatat ttagacattc ttctttctgt tgatagttta tatctgcaaa tgtaaggaaa
    13201 taaagtcgat ttccgtatag caggaatgta aaagttaaca aaaaagggaa gtatacccaa
    13261 gttattattt aacaaagctg atatattgaa gtagcgttcg cgccaattca gagtcctcgc
    13321 cattccgttt cacttcgtga ccatacgcct cacggaaaca agccagcgca tctttccgtt
    13381 cataacaata tttgtgtaaa acccctaagt tttgacaagc cacaatcgta tcttcattct
    13441 cccatccctg atgcttcttt cgcagttcaa actctttgaa gaaagccgct ttcgccattg
    13501 gataatcctt ctttttcgta taagccagtg ctttgtagta atataccaga caggaagaat
    13561 cggggtcacc atcatcatga atatccaggg aggttgctat acgaatcaca ttatcataat
    13621 ctttattcat gtaatattgc tgcataatat cacatcttaa tgcctcgtaa cggatagtca
    13681 attctgccaa acgaggcttt tcgctgaaaa acacttcatg cagaagagac tcatggaaga
    13741 ataaagtagc ggcctgctca tcgttacgct cattcattat gcgtttgaat tctatgcata
    13801 gataatacaa ctgtttatga caagcgacta tctgctttct attatctatc tgcatagaaa
    13861 tatccaatgc ccgattcatc agattccacg cttcatcgta ttgcttaaca caataaagac
    13921 atctaccttg catacgcatg catttagcca ctccacttga caatctacca ttcaaagatt
    13981 cgtgcatttt agctactttc cggaattgtt cggccgcact ctcttcgttt ttcttataat
    14041 aatcgcaata agccagcagt tcgtaaagtt caatgatttc tgccatatta ttctcgtcag
    14101 tagaagccgc atgatagcca agcgctctat ttagataagt caccgcttca ttatattgcc
    14161 cattataata acatgccatc cccaaattcc tacatgtatc agtaatctgg ggtaccggaa
    14221 tcggtactat attttcctgc atcatcaatg ctttcaggaa acaatcacat gccatttcat
    14281 attcttcgtc acgggcatag cgacatccct cgttcatttt cagcactgat ctggcaattg
    14341 gcggtatggc agctccttcc atacatttct cactcacaac atttgctacc tttgtcaggt
    14401 gaaaagaacg acttaagaaa gtagctatat cattagcaat gacaggaatc aaaaaagaat
    14461 caacctgacc aaagtccgat tcggcataga catcaggcat aaaagaagag tcgtcgctca
    14521 taagtgcctt ccagcaatct tccaacaaag aataattcgt acgatacaga atttcgaaga
    14581 gttctacatc acaaatccac tttctcaaga aattccgctc ctgcatctta taaccttgat
    14641 aagtaatttc cactttatag cgataagaat catggtagca gaactgtttc atacgatagc
    14701 tataatcagc aaaagtcagt tggtgcgaaa ggatatcttc attgtccaga aaagaggtta
    14761 ttattttatg acgacactta tcgatgcaca tatcgccttg agcgaagcat cgtttaatcg
    14821 cctctaccat ttgtgtgtca caaatacaat atcgccctcc tttgttggtg agccagctac
    14881 tcatttccac tttcaactgt gaccaaagca tctgatttat gcctgccatg ctctttactt
    14941 catcttcggt aaatccttct aaagtaagtg aaagcatcag aagcgttctt ccaatctctt
    15001 cgaaaccata atcagccgac aaacgccgaa gcacactgtc ataaaattgc tcaacctcat
    15061 tgagccggca atatccactc atatattcat agagagcatc gtactgaccg aacgaaacca
    15121 gctcattgag caatacactt aaacagcgcg gttgtttagc cagcacccac gaaccaagaa
    15181 tatcttcctg ctgtgcagac aaggtcttgg agtaagcaga caaatattgt tttgagaact
    15241 ccttagcatc cacttgtgaa aaaccattca actggaaatg aacgt
//
