LOCUS       c00031_gnlPro..        16331 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FJELFJFC_31.
ACCESSION   c00031_gnlPro..
VERSION     c00031_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 18:40:36
            Original ID  :: gnl|Prokka|FJELFJFC_31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16331
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16331
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2782:6331](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2783..6331
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16331
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16331
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(210..1409)
                     /locus_tag="ctg31_1"
                     /transl_table=11
                     /translation="MTKKALYIFNPEHDLALASGETNYMAPASARQMASELALLPMWYA
                     EEGSVVLAPSAYNLDYVKKIQELLGLSVDLMTEPELASERNLDIRPWGWDIAIRKRLLD
                     LGVEESELPSIEQLDKLRFCSHRSCAVGLLPQLQLGACFCGESFYLTFPEEWKSFVESH
                     DTCLLKAPLSGSGKGLNWCKGVYTPSISGWCSRIGNQQGGVIGEPLYNKVEDFAMEFRS
                     SGNGRFGFAGYSQFRTGGSGAYEGNLLISDAAIERNLSEYIPVEEIYKLRDRLEQELSL
                     RFGTIYNGYLGVDMMICRFPESPVYRIHPCVEINLRMNMGVVARHIYDHYIYPTSTGAF
                     QISYYPTEGTAWRAHKEMEEAYPLEIEQGRIKSGYLSLVPAHKKSSYRAWVFISKSVFL
                     "
     CDS             1572..2750
                     /locus_tag="ctg31_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     RELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2783..6331
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg31_3"
                     /sec_met_domain="PFOR_II (E-value: 1.4e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.7e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.5e-31, bitscore: 100.6,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.2e-12, bitscore:
                     37.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 6e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 9.2e-09, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.6e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 3.6e-25, bitscore: 78.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDNPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     EQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTAKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAQAENWTYCAENVKTKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIAADCTPAEVKELFAEWINNMLDADKTKE
                     LAAKIIPVVEANKDKCNHCKQIAELQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLAKENWGAE"
     CDS             complement(6454..7440)
                     /locus_tag="ctg31_4"
                     /transl_table=11
                     /translation="VKNKIYLLLIYTLIIIACSGQTCAQRQASLQEIESFPVKKSFYAE
                     KIRVNEIFSPDGIEIKKGNLFVTDSRNNDAMLYQYSLPDFHCIYQGGVRGGGKDEFQIS
                     PTLCKTISDKVYIWGYTPLLIKCFMLNNNHMSLEKEFKLPISDGIVNFMNVINDSLLIY
                     STFPYKLNIEKVNLNTMQITGRILIEQKQKELFFDENRGYLAANDSLIIYAYTYKKQID
                     FYRVSDMKLCKRFIDNTVVPHIIVNNVKETKFCQRELVAGKRYFYIRCPKKEKGCFIEV
                     FDYSGHSVAKYELDVLLYAFDVDEENGIIYGYNSDVFEDGFLKYTIL"
     CDS             complement(7603..7905)
                     /locus_tag="ctg31_5"
                     /transl_table=11
                     /translation="MKKGFYGLAALIIAVACYGVHVTYNSKNGLTRLTLLNVEALANDE
                     FTAGFKQCYIFTSTTLLPDEPAFYVTSCNDCNTVKSTTSMGASTCAGSFPNLPGW"
     CDS             7986..8210
                     /locus_tag="ctg31_6"
                     /transl_table=11
                     /translation="MLFSRLCIIFHWRLWRYNPALEEEGKNPFQLDNKEPNWKKSHGFM
                     RGEFRYASVMKQYPTETEELFKGAEANAK"
     CDS             complement(8363..9226)
                     /locus_tag="ctg31_7"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSGLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFLG
                     EVYGEARVGLVVPQYVTIQSISELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRQLVDSW
                     IPKSKK"
     CDS             complement(9247..10071)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.5; E-value: 8.7e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg31_8"
                     /sec_met_domain="BPD_transp_1 (E-value: 3.7e-29, bitscore:
                     92.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETVINWMMVHFSTFFDAINAGIGSFIIGFQHVLFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(10068..11294)
                     /locus_tag="ctg31_9"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGHEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTAGQVFVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEERAKKAMESMMLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSRQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETHEFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(11591..11929)
                     /locus_tag="ctg31_10"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMPQ
                     CSRMVGRALKQIPDDLSVPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVSE"
     CDS             12025..13401
                     /locus_tag="ctg31_11"
                     /transl_table=11
                     /translation="LLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLFGVFAFS
                     SCEKNLYDESKQPEKEIQVKDLDIPAGFQWKLTQVAAGTVAATTPTMVSFFLDEACSKE
                     EKIADIPVDTEISSLPLSIPTYVNTLYAQYKTSTNETKKVAIPVNADRSFSLNIANDAK
                     SKSNTTRSITRGHDIEDDIQLSKGVIFHPKDGWGTIMFEDQFPSLGDYDFNDFVVNYKV
                     QFQGIRKVDKKYTAQYIQIGLRLKAIGGIFPYSPYLRLKEIDSDEVESIEVYETKNVIP
                     AIDGVELVPNKHLIIDYSPLIKNLAKPAGSQYYNTEKNALVATSDLPEINILITLKKRK
                     EVKEILEGDEFDLYLKRNDSGTEIHMNGIEPITYQYPFNDKNLLPVYTNGDEEDDNYYF
                     SAGRLIWGLRVPGNAAHAIEKANFLEAYKGFAKWAQSSGKNEQNWYNQGNADKSLLIHN
                     "
     CDS             complement(13482..16310)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 61.6; E-value: 2.6e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg31_12"
                     /sec_met_domain="Peripla_BP_1 (E-value: 1.1e-19, bitscore:
                     61.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMGYTKWIAVLLCLLGMTACRQDTHRFRIGVAQCSDDSWRHKMND
                     EILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDEGVDLLIISANEAAPMTPIVEEAY
                     QKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGSTPA
                     MERHQGFMAAISNFPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRIAPG
                     AYQAAKKVGREKEMIFVGIDALPGKGNGLEMVLDSVLNATFIYPTNGDKVMQLAMNILE
                     KKPYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQVVMY
                     GGLVILLLVAGLLLVVYKSLRAKNRLNKELSEQKKQLEEQRDKLEEQRDQLEEQRDKLE
                     EQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADHTLSGDQHRML
                     MLIQRNVNILLRLVNQILDFRKYENGKMEYTPVQVDVLSSFEGWNESFLAAARKKHIHF
                     SFDNMPDTDYHTLADMEKLERIYFNLLSNAFKFTPENGKITVRLSSLTKEDTRWIRFTV
                     ANTGSMISAEHIRSIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTISVESDEKQGTVF
                     TVDLPVQTCETILAEDSLKSSISAVPLNPASPGSPASSNLNETLAVEEEELEKGYDSSK
                     PSVLVIDDNADIRSYVRGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGI
                     ECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVRNLID
                     SHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGLSRVQ
                     LYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCYREQF
                     GESPTDLLKRKG"
ORIGIN
        1 aagtaaactt atttaggttt taaaaaatat tgagtaaact aacttaggta taacaagcga
       61 agttgtcaac taaatccagt acagtacaca catggcatgt gattacttgt ttcatgcaat
      121 aaaacttttt gtttctcggt gtggaaccaa tggtttcact acatgaaact atcagtttca
      181 caccgagaaa ccataacttc gatataatat cacaaaaaca cgctttttga gataaacacc
      241 cacgcccgat aactactctt tttatgagcc ggcaccaatg acaaatagcc tgattttatt
      301 cttccttgtt ctatttccaa aggataagcc tcctccattt ctttgtgtgc tctccaggct
      361 gttccttccg tagggtaata gcttatttga aaagctcctg ttgaagtagg atagatataa
      421 tggtcataaa tatgacgcgc tactactccc atattcatcc tcaagttgat ttccacgcaa
      481 ggatgaatcc gataaacagg agattctgga aagcgacaga tcatcatatc cactcccaaa
      541 taaccattat aaatggttcc gaaacggagg gataattctt gttcaaggcg gtcgcgcaat
      601 ttataaattt cttcgacagg gatatattcc gaaagattcc gttcgatggc tgcatctgaa
      661 atcagcagat taccttcgta cgccccactt ccacccgtac ggaattgaga gtatccggca
      721 aaaccaaatc gaccattacc cgaagaacga aattccatag caaaatcttc caccttatta
      781 tatagaggtt cgccaataac acctccttgc tggttgccaa tgcgtgagca ccaaccggaa
      841 atggaaggag tatatacacc tttgcaccaa ttcaaccctt ttccgctacc ggataaagga
      901 gctttcagta aacaagtatc atgtgattct acaaatgact tccattcttc gggaaacgtc
      961 aggtaaaaag actctccaca aaaacaggct cccagttgta gctgtggtaa taatcccaca
     1021 gcacaggaac gatgggaaca gaaacgcagt ttatccaatt gctcaataga aggaagctcg
     1081 ctttcttcca ctcccaaatc caacagtcgt tttcttattg ctatatccca gccccaagga
     1141 cgaatatcca aattccgctc cgaagcaagt tcaggttctg tcatcaaatc aaccgaaagt
     1201 cctaataatt cctgtatctt cttcacatag tcgagattat aagcggaagg agccaataca
     1261 acacttccct cttctgcata ccacatcggc aacaaagcca attcggatgc catctgccgg
     1321 gcggaagccg gtgccatata gtttgtttca ccgctggcta acgccaaatc atgttccgga
     1381 ttgaatatat aaagagcctt ttttgtcatt ttaaacgaat tcaaaacttt attctgcaaa
     1441 tatatacagg aaatagtcag gaatggctac aataaacaga aagttctaat taaactcaca
     1501 attttgccat ctctactttg caaatcctaa aaaaagcagt atatttgcca cccgaaaaac
     1561 aaagaactga aatggaatca ttctatcgca cacacgccta cctcgttgag cacaccaatg
     1621 cccccgttcg ccgcgatctt atggacgaga tcgactggag cgaccgcctg attggtatca
     1681 aagggacacg tggcgtagga aaaaccactt tccttctcca atacgccaaa gaaaaatttg
     1741 ggaacgaccg ctcctgcctg ttcatcaaca tgaacaactt ctacttctct ggccacagca
     1801 ttgtagactt tgctaacgaa ttccagaaac gtggtggaaa agtattgttg atcgaccaag
     1861 tgttcaaaca cccggaatgg agcagagagt tgcgcatgtg ttacgaccgt tttcctaatt
     1921 tgaaaattgt ctttaccggc tcgtccgtga tgcgactgaa agaagaaaat cttgaattac
     1981 gtgatatcgc caagagctat aacctgcgtg gattctcttt ccgtgaattc ctaaacttgc
     2041 aaacaggcat gaaattcagg gcatatagcc tcgaagaaat tcttagcact cacgaacaga
     2101 ttgccaaagg agtactctcc aaagtccgtc cgttggatta ttttcaggat tatctgcacc
     2161 acggattcta tccgttcttc cttgaaaaac gtaacttttc ggagaatctg ctgaaaacga
     2221 tgaacatgat ggtggaagta gatatacttc tcatcaaaca aattgaactg aaatatcttt
     2281 caaagataaa aaaattgcta tatttgctcg ctgtcgacgg gccgaaagct ccaaatgtga
     2341 gccaactggc aagcgacata cagacatctc gcgccacggt gatgaactat atcaagtatc
     2401 tggcagatgc gcgactcatt aatctggttt atccgaaagg ggaagaattc cctaaaaaac
     2461 cttcaaagat aatgatgcac aactccaacc tgatgtattc catctatccg gtgaaagtgg
     2521 aagagcagga tgtgctcgac acattctttg caaattcttt atggaaagac cataaggtac
     2581 ataaaggaga taaaaacgtc tcttttatgg tagacgaagt aatgccgttc aaaatttgcc
     2641 aggaaggcgc aaagatcaag aacaatccga atgtaacgta cgcgttgcat aaggctgaaa
     2701 taggtcgggg caaccagata cctctctgga tgttcggctt tttatattaa aagatttatt
     2761 tacttaaata tttaatttag ttatgactaa acagaagaaa ttcatcactt gtgatggtaa
     2821 ccaagctgca gcgcatatct cgtatatgtt ctctgaagta gcagctatct accccatcac
     2881 tccttcttcg actatggctg agtacgtaga cgaatgggct gccgcaggac gtaagaacat
     2941 cttcggcgaa acagtattag tacaggaaat gcaatctgaa ggtggtgctg ccggtgcagt
     3001 tcacggttct cttcaggctg gtgcgttgac tactacttac actgcttccc agggtcttct
     3061 cctgatgatc cctaacatgt acaaaattgc cggtgagttc ttgccttgcg tattccatgt
     3121 gtctgctcgt acattggctt ctcacgcatt gtgtatcttc ggtgaccacc aagacgtaat
     3181 gtcagctcgt cagactggct ttgctatgtt ggctgaaggc tctgtacagg aagttatgga
     3241 tttggctggt gttgctcact tggctaccat caaatctcgc gttccgttca tgaacttctt
     3301 cgatggtttc cgtacatctc acgaaatcca aaagattgaa atgttggaaa atgatgatct
     3361 tgctccgctg atcgaccagg aagctttggc tgaattccgt gcccgcgcac tgaacccgat
     3421 gaaaccggta gctcgtggta tggctgaaaa tcctgaccat ttcttccaac atcgtgaatc
     3481 atgcaacaac tactatgaag cagttcctgc tatcgtagaa gaatacatga atgaaatttc
     3541 taagatcaca ggtcgtaaat acggtttgtt cgattactat ggtgcagaag atgcagaacg
     3601 cgtaattatc gctatgggtt ctgtaacaga agctgcccgc gaagctatcg actacctggt
     3661 agcaaacggc gaaaaagtgg gtatggttgc cgtacaccta tatcgtccgt tctctgctaa
     3721 acacttcttg gctgctgtac ctaagactgc taaaactatc gcagttcttg accgtactaa
     3781 agaaccgggt gctaacggcg aacctcttta ccttgacgtt aaagactgct tctacggtgc
     3841 agaaaatgct ccggttatcg ttggcggtcg ctacggtttg ggttcaaaag atactactcc
     3901 tgctcaaatc ctttcagtat tcgaaaactt ggctatgcca atgccgaaga accacttcac
     3961 tatcggtatc gtagacgacg ttactttcac ttctcttcct caaaaagaag aaatcgcttt
     4021 aggcggcgaa ggtatgttcg aagctaaatt ctacggtttg ggtgctgacg gtacagtagg
     4081 tgctaacaag aactctgtaa agattatcgg tgacaacact gacaaacact gccaggctta
     4141 cttctcttat gactctaaga agtcgggcgg tttcacttgt tctcatttgc gtttcggtga
     4201 caatccaatc cgttctactt atctggtaaa tactccgaac ttcgttgctt gtcacgttca
     4261 ggcttacctg cacatgtacg atgtaactcg tggtttgcgt aagaacggtt ctttcttatt
     4321 aaacacaatt tgggaaggtg aagaactggc taagaacctg cctaacaagg ttaagaaata
     4381 tttcgcacag aacaacattt ctgtatacta tatcaacgca acacagattg cactggaaat
     4441 tggtttgggt aaccgtacca acacaatcct tcaatctgca ttcttccgta tcacaggcgt
     4501 tattcctgta gaacaagctg ttgagcagat gaagaaattc atcgttaagt cttacggcaa
     4561 gaagggtgaa gacgttgtta acaagaacta tgctgccgtt gaccgtggtg gtgaatacaa
     4621 gactttggct gttgatcctg cttgggctaa ccttccggat gacgcaaaag ctgaaaacaa
     4681 cgatcctgca ttcatcaacg aagtagttcg tccgatcaat gcacaagacg gtgacttgtt
     4741 gccggtatct gcattcaagg gtatcgaaga cggtacttgg tatcaaggta ctgctaaata
     4801 cgaaaaacgt ggtgtagctg cattcgttcc tgaatggaat ccggaaaact gtatccagtg
     4861 taacaagtgt gcatacgttt gtcctcacgc ttctatccgt ccgttcgtac tcgacgctga
     4921 agagcagaag ggtgctaagt tcgaacaact gaaagctgta ggtaaagcat tcgacggtat
     4981 gacattccgt atccaggtgg acgttctcga ctgtctgggt tgcggtaact gtgccgacat
     5041 ctgtccgggt aatccgaaga agggtggcaa agcattgaca atgaaacacc tcgaaagcca
     5101 attggctcaa gctgaaaact ggacttactg tgctgaaaac gtgaagacta aacaacatct
     5161 tgttgatatc aaggctaacg tgaagaactc acagttcgct actccgttgt ttgagttctc
     5221 cggcgcttgc tctggttgtg gtgaaactcc atacgtgaaa ttgatttctc aattgttcgg
     5281 tgaccgtgaa atggttgcta acgctaccgg atgttcttct atctactctg gttctgttcc
     5341 ttctactccg tatactacaa acgaaaacgg acacggtcct gcttgggcta actcactgtt
     5401 cgaagacttc tgtgaattcg gtttgggtat ggaactggct aacgaaaaga tgcgtgctcg
     5461 tctcgtgaaa gtgatgaacg aggctattgc tgctgattgc actcctgctg aagtaaaaga
     5521 actgttcgct gaatggatca acaatatgct ggatgcggac aagactaagg aattggctgc
     5581 taagatcatt ccggttgttg aagctaacaa ggataaatgt aaccactgca aacaaatcgc
     5641 tgaactgcaa caatatcttg taaaacgcag ccagtggatc attggtggtg acggtgcttc
     5701 ttacgatatc ggttacggtg gtcttgacca tgtaatcgct tccggtaagg acgttaacat
     5761 cctcgttctg gatactgaag tttactctaa cacaggtggt cagtcttcta aagctactcc
     5821 ggtaggtgct atcgctaagt tcgctgctgc tggtaagcgc gtacgtaaga aagacctcgg
     5881 tctgatggct actacttacg gttatgtata tgttgcacag atcgctatgg gtgctgacca
     5941 agctcaaact ctgaaagcta tccgtgaagc tgaagcatat ccgggaccat ctttgattat
     6001 cgcttacgct ccatgtatca accacggtct gaaagcaggt atgggtaaga gccaggaaga
     6061 agaagaaaaa gctgttaagt gcggttactg gcacttgtgg cgttacaacc cggctttgga
     6121 agaagaaggc aagaacccat tccaattgga tagcaaagaa ccgaactggg aagatttcca
     6181 aggtttcttg aagggtgaag ttcgttacgc ttctgtaatg aaacaatatc ctgctgaagc
     6241 tgaagaactg tttaaagctg ctgaagaaaa cgctaaatgg cgttacaaca gctacaaacg
     6301 tttggctaaa gaaaactggg gtgctgaata aagagctatt tttaagaaag aaaaggcgga
     6361 atccctaaag gatccgcctt ttttactaca tgttaaaaat acctttaatc aatataccct
     6421 tggctcaccc aacaaattag gagagttcgt gcattacaag atagtatact tcaaaaagcc
     6481 atcttcaaat acgtcactat tataaccata tataattcca ttctcttcat ctacatcaaa
     6541 tgcatataat agaacatcca gttcgtattt ggcaacagaa tgtcctgaat aatcaaaaac
     6601 ttcaataaaa cagccttttt cctttttagg acatcttata tagaagtacc gcttaccggc
     6661 aactaattca cgctgacaga atttggtttc tttaacattg ttcactatta tatgaggtac
     6721 tacagtatta tcaataaatc tcttgcagag cttcatatcg cttactcgat aaaaatctat
     6781 ttgcttttta taggtataag catagattat tagagaatcg ttagctgcta aatatcctct
     6841 attctcatca aagaataatt ccttctgctt ttgctcaatc aaaatccgcc ccgttatctg
     6901 catggtattc aaattgactt tttctatatt aagtttatag gggaatgtac tatatattaa
     6961 taaggaatcg ttgataacat tcataaaatt gactattcca tcagagatag gtagtttaaa
     7021 ttctttctca agagacatgt gattattatt caacataaaa catttgataa gcaatggagt
     7081 gtatccccaa atataaactt tatcagaaat agttttacat aatgtggggg atatttgaaa
     7141 ttcgtctttt ccacctcctc taactccacc ttgataaata caatgaaaat caggaagtga
     7201 atattgatat aacatagcat cattatttct tgaatctgtt acaaaaagat ttcctttttt
     7261 tatctctatt ccatcaggag agaatatttc atttactctt attttctccg cataaaaaga
     7321 ttttttcact ggaaaggact caatctcttg taaagatgcc tgcctttgtg cacaagtttg
     7381 tccactgcat gcaataataa ttaaagtata aataagtaat aaataaattt tatttttcac
     7441 cgtattgttt attctttcta aaatgactat cttaattcaa taaataagcc tatataatac
     7501 tgcatctatc atttaaaggg ttttaaccca aagtatcatt ttttatgtat gaaaaaaaat
     7561 gatactttct aatgaataaa atatctatag gctataataa agttaccatc ccggtagatt
     7621 aggaaaagaa cctgcacagg tagaagcacc catactcgta gtggatttta ctgtattgca
     7681 gtcattgcac gacgtaacat aaaatgcggg ttcgtctggt agtaatgttg tactagtaaa
     7741 aatgtaacac tgtttaaacc ctgcagtaaa ctcatcattt gccaaagcct ccacgttaag
     7801 aagtgtcaac cgggttaatc cattttttga attatacgtc acatggacgc cataacaagc
     7861 aactgctata atcaaagcag ctaagccata aaatcctttt ttcatcttga taagtattta
     7921 atttgttatt ttgtgtattt cctgtaaata taccgattta ttagttgtaa gtaatatatt
     7981 attctatgtt attcagcaga ttatgtataa tttttcactg gcgcttgtgg cgttacaacc
     8041 cggctttgga agaagaaggc aagaatccgt tccaattgga caacaaagaa ccgaactgga
     8101 aaaagtccca tggtttcatg aggggagaat ttcgttatgc ttcagtaatg aaacaatatc
     8161 ctactgaaac tgaagaactg ttcaaaggtg ctgaagcaaa cgctaaatag cgttataata
     8221 gctataaacg tggctatgct gaataattaa tcacactctg ataaatataa aaatggaagt
     8281 ctgttcaatg catgactccc atttttatgt tcaatccttt tcttatgtct aaatcgattc
     8341 cgaataaaaa actgtaccaa ccttattttt ttgacttcgg aatccaacta tccaccaact
     8401 gccgatgttc atccctccat ttgcgggcta tttcttcttc atccatccgg gcatccttca
     8461 tagctgtcat aaaagagcta agttcttctg tcgttagttt aatgttgcca aagaattcgg
     8521 cagcaaacgg atctttctca ctgaatcctt tccatgcaat agcatgtatt tcttccaagt
     8581 ctccatatac tttcttcgga tcatccaaga atttcaagtc aaactggtcg aacatccaat
     8641 gcggtgtcca ccccgtgatg acaatccatt ctcctttgtc catcgctttt ttcaaagaag
     8701 ccagcatggt ggaactactt gaagtcatga gggtataccc atcaagtccg taagcagcaa
     8761 tggccttatc ggtcgtcttc attatccctg ctcccgcatc aattcctact atttcagaag
     8821 agaaacggtc tttattagct tccagctcac taatagactg gatcgtaaca tattgaggaa
     8881 caaccagtcc tacacgggct tctccatata cctcccccaa aaattcgatg ctgtctccat
     8941 actgatccat ataatctttc atcgttattg gtaaccatgc atccagaaag acatcagatt
     9001 tctttcctga catagataca aaaatagggg caagatcagc attttgcaat tcaacctcat
     9061 atccatgctc ttccaatacc accttggcca aatgactcat ggcaatacct tccagccaat
     9121 tggcataggc tatttttact ttctttttct ctaagcctga attagtacag gaagctagca
     9181 aaagcatagc tgacaatact attcctacta ttttatatat tctcatacgt attttatcct
     9241 ttccgtttag ttcttatttt ttcgtcctgc cattccttgt gtgatacggt ctaagataat
     9301 agctaaaata acaactgcta taccaccttc aaacccaagt ccgattttca tttgggtaat
     9361 acctttcaat acaatttctc ccagaccacc ggcagcaatc atggcagcaa tgacaaccat
     9421 agaaagcgac atcattattg tctggttgac accagtcagg atagtgggca acgccaaagg
     9481 aagctgcact ttatacaata actgccaacg ggtagctccg aacgaacggg aagcttccac
     9541 tacattttta ggaacttgcc gtattcccaa tccggtaagg cggaccacag gaggcatagc
     9601 aaagataatg gtggcaaaca ctcctggcac tgctcccaat ccgaaaaata aaacggcagg
     9661 aatcagataa acaaaagcag gcatcgtctg catcaagtcg agaacaggac gaagtatttt
     9721 ctctgcacgc ggactgtttg ccgtccacac tcctaaaggt acaccaacaa tcagggccag
     9781 acaggtagat gaaaaaacaa gagccagggt ttgcatagta gcctcccaaa atcccattcc
     9841 ataaatcagt aataatccca atgcggtgaa aattgccgta ccacgtcctg ccttcatcca
     9901 tgcgagtgca gcaagcacta gaatggttat ataaaaaggt attccaaaaa gtacgtgttg
     9961 gaatcctata ataaaactac cgatgcctgc atttatggca tcaaagaaag tggaaaaatg
    10021 taccatcatc caattgatga ccgtctctat atattgtcct atatttatca taaatctatt
    10081 gcgttttgaa ttatttcgtt tatttcttct ttatctttcc ccgtcacttc gatgattaag
    10141 gaggaaagcg ggattgttcc taaaaactca tgcgtctcat caatcaccca taccggcgaa
    10201 ttgctctttg tcattaaagg aagtatatcc tccaacactg tatcctccaa tacagaatgt
    10261 acttctgtac gcacaatcgt ttcaatggat ttttcctgtc tgctacgtaa cttaagcagg
    10321 tcgttcagac gtacttctcc aaccagttta tcatcggcgt ctatgacagg taatacggtg
    10381 atattcttcg cacgcatctt acgaatcaat acttcaggtc cctctttctt caaacgggcc
    10441 accagtggtt tgtcaatcat taaagaagaa gcggtgataa ttttactcct gtccacgttt
    10501 tcaacaaaac gggctacata atcgttagcc ggttcggtca gtatttcttc tgaagtacct
    10561 acctgcacca cctctccgtc tttcataatg gcaatacggt cgcccagttt aatcgcttca
    10621 ctcaagtcat gggtaataaa gacaattgtt tttttcatct tcgattgcaa agccaacagt
    10681 tcatcctgca tttgcacacg aatcagagga tcgagcgcag agaaagcctc atccattaga
    10741 agtacttcag gattattagc cagggcacgg gccagtccga cacgctgttg cattccaccg
    10801 gaaagctcgc ctaccatctg attttcgtat cctttcaatc cgacaagcat catgctttcc
    10861 atagctttct tcgcacgttc ctctttcttc actccctgaa gttcgagacc gaatgcaata
    10921 ttgctcaata cggaacggtg aggcaacaga ccgaaattct ggaaaaccat cgccagctct
    10981 ttccgacgaa cctgcaataa ttctttttcg gatattttag atatatctac tccgtttaca
    11041 aacacttgcc cggcagtagg acgtatcaga cgattgatac aacgcagtaa tgtcgatttt
    11101 ccacttcccg agagtcccat tatcacaaaa aactctcctt cattaattga aagattagca
    11161 tctttcactc ctaccgtaca accggtatct ttcagaattt cctctttact cttatctttt
    11221 ttcaacatct tgagtgcttt ctgcttctcg tgaccaaaga taaggtacaa atcctttatt
    11281 tctattttac tcatataata tattggttta gattataata gttgttttgt tttcaactgc
    11341 tgcgttcctc attctcactt acgataaaca agttgaatgt tcgcatggtt cagtcatgtc
    11401 acatgacaac atgacgatcc gacgtttttt aaatggtaaa aaaacagact aagtagttta
    11461 aaaggaatag aatttgataa gattatcctc tcaatgaaca gtagaaaaca gtattttcat
    11521 aaataaataa cagtctgttc ttgcatattg ttggcacaaa ggtaaggaaa atagattaaa
    11581 tatgcaaatt tcattcagat acggagtaat tccaaagatg ctttttcaag tctacgcatc
    11641 cattttgctt gaaagagatc ccttcttcca acaagagttg tttctgctct gtccaacccg
    11701 gaacaaggcg tcccgatgca ttgacaaccc ggtgacaagg cacagataaa tcatccggaa
    11761 tctgtttcaa agcacgcccc accatacggg aacattgagg cattcccaat aatgcggcaa
    11821 ttcccccata ggtagaaact ttacctaccg gaatttcccg aacaacctga tacacctctt
    11881 gacaaaagga tgcggagaga ctcgctttgt ctactttata atctttcatc actcaaacat
    11941 tactttattt cagttccaaa actagataaa aaggaaagaa tttgcaaata ataaaagtat
    12001 ttcaaataaa atatgcaact ttatttgctt tatttacaaa taatcccgac ctttgtaccc
    12061 attaaaagca accctattat taacaaaaca agcactgctg ttatgaaaaa gaagacaatt
    12121 ctattcgctt cttgtttatt tggagtattc gctttcagct cctgtgagaa gaacctttat
    12181 gatgaaagca agcaacctga aaaagaaatt caagtaaaag acctggatat acccgcaggc
    12241 tttcaatgga aattaactca agtagccgca ggaacagtag ctgctactac ccccactatg
    12301 gtttccttct ttttggatga agcatgtagt aaagaagaga aaatagccga cattcctgta
    12361 gatacagaaa tttcaagtct ccctttgagc atcccaacct acgtaaatac attgtatgcc
    12421 cagtacaaaa ccagcaccaa tgaaaccaaa aaagtagcca tacctgtaaa tgcagataga
    12481 agtttctcac tgaacattgc taatgatgcc aaatccaaat ctaacaccac ccggtcaatc
    12541 actcgtgggc atgatataga agatgacatc caattgtcaa aaggagtcat ttttcatccc
    12601 aaagatggtt ggggaacaat catgtttgaa gaccaatttc catcattagg agattatgac
    12661 tttaatgatt ttgtagtcaa ttataaggtg cagttccaag gtattagaaa ggttgacaaa
    12721 aaatacactg cgcagtatat acaaataggg ttacgtctaa aagctatcgg aggaatattc
    12781 ccttattccc cttatttaag actgaaagaa atagattctg acgaagtgga aagtatagaa
    12841 gtttatgaaa ctaaaaacgt gattcctgcg atcgacggag tagaacttgt ccccaataaa
    12901 catcttatca ttgattacag ccctttaatt aagaatctgg ctaaacctgc aggcagccaa
    12961 tattataata cagaaaagaa tgctttggta gcaacaagtg atttaccgga gatcaatatt
    13021 ctgatcaccc taaagaagag aaaagaagta aaggaaatat tagaaggcga tgaattcgac
    13081 ttgtatttaa aacgtaatga tagcggaaca gaaatccata tgaatggtat tgaaccgatc
    13141 acttaccaat atccattcaa tgataaaaat ctgctaccgg tatatacaaa cggggacgaa
    13201 gaagatgata attattattt tagtgcagga cgcctgattt ggggattaag agtaccaggc
    13261 aacgcagcac atgctattga aaaagctaat ttcttggaag cctataaagg attcgcaaaa
    13321 tgggcgcaaa gtagtggcaa aaacgaacaa aactggtata atcaaggaaa cgcagataaa
    13381 agtttattga ttcataacta acacatatca ataaatcccg gtaaacattg aaaattcaag
    13441 ttaccgggat ttattgtatt ctgacgtgaa tagttttgat tctatccttt ccttttcagc
    13501 aaatctgtcg gactttcacc aaactgctct ctataacatt tggtaaaata agaaggagaa
    13561 ctaaaaccga cttcataacc aatctccgcc actgtcatat ctgacgaagc aagcagggaa
    13621 gcagccttct tcaagcgagc gatgcgaagc aattcattcg gagaataatt agtcagggat
    13681 tttattttgc gatagagttg cacacgactt aatcccatat ccttacccaa atcctctaca
    13741 ttcaaatttg aatctcccat ctttgcttca attaaagcct tgaatttttc cacaaagtct
    13801 ttatccatat cacagacatc ctctttcgcc aacgtttgtc cgtcaccaaa gaactgtttc
    13861 aggcggcgat gtgaatctat cagattacga acgcgtgcca acagcaattg cgaactgaag
    13921 ggcttggaga tataagaatc cgcacctccg tcatatccct gaatccgttg ttcatccaaa
    13981 gaacaggctg tcaataggat gacagggata tggcaggttt gcagttcgct tttcagccga
    14041 cggcaacact ctattccatc aataccaggc atcatcacat cagagattat caagtccgga
    14101 acatatttca ttgctttgcg aataccctcc gaaccgtctg ctgcttcaat aacagtataa
    14161 tcggtatgga gtaatccgcg tacatacgaa cggatatctg cattatcatc aattaccaaa
    14221 acagaaggtt tggaagaatc atagcctttt tccagttcct cttcttcgac agctaaagtt
    14281 tcattcaggt tggaagaggc aggagaaccg ggagaagcag gatttaaagg aactgcagag
    14341 attgatgact ttagagaatc ttcggccaga atagtctcac aagtctgtac cggtaaatca
    14401 acggtaaaga cagtgccctg cttttcatca ctttccacag aaattgtacc tttatgcaat
    14461 tcaacgaaag ctttaaccag tgcaagcccg attcccgaac cggcgtggtg catgtctatt
    14521 ttataaaaac gatcgaaaat actccggata tgttcggcgg aaatcattga accggtattg
    14581 gcaacagtaa aacgaatcca gcgagtatcc tctttcgtca aggaagataa acgaaccgtt
    14641 atctttccat tttccggtgt gaacttgaac gcgttggaaa gcagattaaa ataaatacgt
    14701 tccaactttt ccatatccgc caacgtatgg taatccgtat ccggcatatt atcaaaagag
    14761 aaatgaatgt gtttcttccg ggcggctgca aggaatgatt cgttccagcc ctcaaaagag
    14821 gaaagaacat ctacctgaac tggtgtatat tccatcttac cgttctcgta tttacggaaa
    14881 tccagaatct gattaacaag acgcaaaagg atattcacgt ttcgttgaat cagcatcaac
    14941 attcgatgct gatctccact tagtgtatga tcggccaata aatgttctac cggatcggca
    15001 accaatgtca gcggagtacg gaaatcgtga gatatatttg tgaagaaaac cagtttggca
    15061 tgcgttgcct cttccagttg atgagaaagc tggatgagct gatcccgttg ctcttccagt
    15121 ttgtcccgct gttcttctaa ttggtcgcgt tgttcctcta acttgtcccg ctgctcttcc
    15181 aactgtttct tctgctcgga aagttcctta ttcagacgat ttttagcacg gagagattta
    15241 tagactacca ataataagcc tgccaccaat agaagaataa ccaaaccacc atacatcacc
    15301 acctgctgtg tagcaacccg agacagatat ccgccgatac gtccgttcaa tgtttcaatc
    15361 ttctgatcca gttccgagat gtgagttgtc tgaagttgca tgacatgtgc atttgtacgg
    15421 tcgaccaccg cagtgttcat gaccgtttcc cggggataag gctttttctc aaggatattc
    15481 attgccagtt gcatcacttt gtcgccattg gtcggataaa taaaagttgc attcaacaca
    15541 ctgtcgagca ccatttccaa tccgttgcct ttgccgggga gagcatcgat accgacaaaa
    15601 atcatttcct tctcccgtcc cactttcttt gcagcctgat aagctcccgg agcgatacgg
    15661 tcattatgcg catacacggc gtctatcttc ggatgccgac ggagcatact atccatttcc
    15721 acttccgccg gttcacgctc ccacgcagca tccgctttat caatcagttt gatatccgga
    15781 aagttactga tagcagccat aaatccttga tggcgttcca tggcaggagt tgagccaccc
    15841 agtccggtaa gttccaccac attccctttt cctttcaggc tcgacgcaat ataattgcct
    15901 accgcacgtc ctatttcata attgtcggca ccaatataag cagtatattt atcagaaaga
    15961 atcttccggt ctaccaggat gacaggtatt cccttttgat aggcttcctc tacaatcgga
    16021 gtcatggggg ccgcttcgtt ggcagagata atcaataagt caaccccttc atctataaaa
    16081 taatgaacgt cttccgcctg tttacgatta tcatccgcag ccgaccggat ttcaaccgat
    16141 actccatcat aaaacattgc ttcgcggaga atttcatcat tcatcttatg ccgccaggag
    16201 tcatcgctgc attgcgccac cccgatacgg aaacggtgtg tgtcctgccg acaagccgtc
    16261 atgccaagaa gacagagcaa gactgctatc cacttcgtat atcccatcat tctaatcatt
    16321 ctcatttttt t
//
