LOCUS       gnlProkkaCBKGKHGP_332   9370 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CBKGKHGP_332.
ACCESSION   gnlProkkaCBKGKHGP_332
VERSION     gnlProkkaCBKGKHGP_332
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 15:25:49
            Original ID  :: gnl|Prokka|CBKGKHGP_332
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9370
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1539
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (47-298). E-value:
                     5.1e-28. Score: 90.0. Matches aSDomain:
                     nrpspksdomains_ctg332_1_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 174.2; E-value:
                     7.3e-53)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg332_1"
                     /sec_met_domain="APE_KS2 (E-value: 1.1e-96, bitscore:
                     313.5, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAIQEVISQSGADLREPDCTLLLSTTKGNIDLLSELPADSPVFL
                     WKMAERIGDFFGATNQVEVISNACISGVSALIVAKRWIESGRYKRVIVAGGDILSHFIT
                     SGFLSFRSVSAHLCRPYDIQRDGLSLGEACGAVLLETQGNANHIILSGGAISNDANHIS
                     GPSRTGDGLALAINQAMEEAGALPEDISFINAHGTATVYNDEMESKAIHLAGLAAVPVN
                     SLKPYFGHTLGASGIIETILCIEQLKEGRYYGTLGYETLGVPMPITVYTTHQPMPMKCC
                     IKTASGFGGCNAALVLSLPDAHLKQKVNLQATDKASAPSVCKAVVESGNMVTIRPGAVE
                     SKGTTVFSSSETDFAPFIREAYKHLGENNMKFYKMDNLCKLGYVAAEYLLKNTHHRPEE
                     IGIILANASSSLDTDCKHQAIISKEGDKAASPAVFVYTLPNVVLGEICIRHKIQGENTF
                     FVRRQSDAASLEDYARIVMAKGKLRTCIIGWCELLDGHYQAEFKQLNNISTIYG"
     protocluster    1..9370
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[0:3007]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..3007
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..9370
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9370
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     aSDomain        142..894
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg332_1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="5.10E-28"
                     /label="ctg332_1_PKS_KS.1"
                     /locus_tag="ctg332_1"
                     /protein_end="298"
                     /protein_start="47"
                     /score="90.0"
                     /tool="antismash"
                     /translation="MAERIGDFFGATNQVEVISNACISGVSALIVAKRWIESGRYKRVI
                     VAGGDILSHFITSGFLSFRSVSAHLCRPYDIQRDGLSLGEACGAVLLETQGNANHIILS
                     GGAISNDANHISGPSRTGDGLALAINQAMEEAGALPEDISFINAHGTATVYNDEMESKA
                     IHLAGLAAVPVNSLKPYFGHTLGASGIIETILCIEQLKEGRYYGTLGYETLGVPMPITV
                     YTTHQPMPMKCCIKTASGFGGCNAALVLS"
     CDS             1532..1813
                     /NRPS_PKS="Domain: PP-binding (22-86). E-value: 1.4e-11.
                     Score: 36.7. Matches aSDomain:
                     nrpspksdomains_ctg332_2_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg332_2"
                     /sec_met_domain="PP-binding (E-value: 2.4e-12, bitscore:
                     36.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNLDQTKRELMDEVKGKLIEELNLEEITPEDIDNEAPLFGDEGL
                     GLDSIDALEIILILEREYGIKIENPSEGKQIFYSVRTLADYIIANRKA"
     aSDomain        1598..1789
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg332_2_PP-binding.1"
                     /evalue="1.40E-11"
                     /label="ctg332_2_PP-binding.1"
                     /locus_tag="ctg332_2"
                     /protein_end="86"
                     /protein_start="22"
                     /score="36.7"
                     /tool="antismash"
                     /translation="LNLEEITPEDIDNEAPLFGDEGLGLDSIDALEIILILEREYGIKI
                     ENPSEGKQIFYSVRTLADY"
     CDS             1817..3007
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (77-388). E-value:
                     1.5e-36. Score: 118.1. Matches aSDomain:
                     nrpspksdomains_ctg332_3_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 258.1; E-value:
                     2.5e-78)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg332_3"
                     /sec_met_domain="APE_KS2 (E-value: 6.3e-129, bitscore:
                     419.7, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIYVTGLGVVSGIGIGVSENIEALRQRKHGIGKVTLFPTALDVP
                     VSEVKRSNEELKQLISLPPQRTVSRTALLGMIAAKEAMKDAGLTPPLRIGFISATSVGG
                     MDLSEHFYESFKKNPGQGRLREVISHDCGASTELIASYLGINDFITTISTACSSAANAI
                     MLGARMIKHGLLDAAIVGGTDALCRFTLNGFNSLMILDKTHCRPFDRSRTGLNLGEGAG
                     YLVLQSESSLQRTPYCELSGYANTNEAYHQTGSSPEGDGAFLSMSEAIASSGISLEEID
                     YINVHGTGTPGNDASEGMALRRIFGEHVPPFSSVKAFIGHTLGASEGIEAVYSVLSIDK
                     GLIYPNLNFTDAMPETGLIPETSFQEGIPIRHVLSNSFGFGGNDSSLLFSATNFPA"
     aSDomain        2048..2980
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg332_3_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.50E-36"
                     /label="ctg332_3_PKS_KS.1"
                     /locus_tag="ctg332_3"
                     /protein_end="388"
                     /protein_start="77"
                     /score="118.1"
                     /tool="antismash"
                     /translation="AAKEAMKDAGLTPPLRIGFISATSVGGMDLSEHFYESFKKNPGQG
                     RLREVISHDCGASTELIASYLGINDFITTISTACSSAANAIMLGARMIKHGLLDAAIVG
                     GTDALCRFTLNGFNSLMILDKTHCRPFDRSRTGLNLGEGAGYLVLQSESSLQRTPYCEL
                     SGYANTNEAYHQTGSSPEGDGAFLSMSEAIASSGISLEEIDYINVHGTGTPGNDASEGM
                     ALRRIFGEHVPPFSSVKAFIGHTLGASEGIEAVYSVLSIDKGLIYPNLNFTDAMPETGL
                     IPETSFQEGIPIRHVLSNSFGFGGNDSSLL"
     CDS             3032..4030
                     /locus_tag="ctg332_4"
                     /transl_table=11
                     /translation="MQPVYIQRIASIHPPKDHSPGNNRPYLQACEPDYKDIITNATLRR
                     RMSRIVKMGVACGLECMGELSPEKIQGIITATGLGCLTDTEKFLNNLLDNEERMLNPTP
                     FIQSTFNTIGAQIALIHQIHAYNMTYVHRGLSFESALLDAMMKIGEGSENMLVGAIDEM
                     TETCYTIQQRLGMLKGIAAGEGAQFFLLSREAGEHPLAEIQGVETFIGKQTTEEISSRI
                     IRFLQRNGLECQDIQWLVTGKNKKQHNQDDSHEQTVDNGNSIYEELETNIFPESVHLSF
                     KNECGEYPTATSYAVWKAVNESANCTTSTHILIYNHHHSINHSLILIRKSV"
     CDS             4027..4704
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235:polysaccharide deacetylase (Score: 126.2;
                     E-value: 2.7e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg332_5"
                     /transl_table=11
                     /translation="MIIVCLLLCLLLLLSFLVYASYSIQSGIYLRSFCKKHTAEKIVAL
                     TFDDGPDSLQTPKVLQVLKEYQVTACFFCIGHKVKGNEAILQKMVAEGHLIGNHSHTHS
                     GLFPLYGLSKMKKDLQTCQCELERVTSQPVSLFRPPFGVTNPTIAKAVRQLGYTPIGWS
                     IRTLDTQQAPDKVLARIRKRLEPGAIILLHDRMPDSDQLVKQILDLLKEQGYTAVHPDK
                     LLA"
     CDS             4717..5352
                     /locus_tag="ctg332_6"
                     /transl_table=11
                     /translation="MRTLLIYLSLFFLSIASIHAQSMKKMAQKTEFESRLAKEAQTVES
                     IESDFTQVKYLDVFDEKVTSKGKFYYQKTHKICMEYFRPMDYLIVINGSKLKIVSDGKK
                     SIMNLSSNKMMAQMQDMLTACMIGDLSKMSSNYLLEYFEDARYYLVKIKPTNKAVQAYI
                     AGIEIYLNKKDMSVHKLRLSETATNYTEYEFYNKKFNSLKNETKFAIR"
     CDS             5327..5887
                     /locus_tag="ctg332_7"
                     /transl_table=11
                     /translation="MRRSLRFVSLTALLFLWIQIQTSCSPRMSGEGSTVPPAIELTQGE
                     SSQKYNIQLDFMKHHMSGMLIVRRMPDNEIRIVASTYFGLSLFDFSLRNDQFTVNSCIE
                     PMKKEKVLKLLEMDFRRLFLSGKDTRVKATKDSATEKRTSGKGFGKSVVYITGNTPGDP
                     AQIKIKHPWIRLTIRLDKLSKEI"
     CDS             5891..6325
                     /locus_tag="ctg332_8"
                     /transl_table=11
                     /translation="MLLDNFYTILSSESSDSTIWTIQIKLNPGHPVYQGHFPEHPVVPG
                     VCLLQLIKECVEDIRQQKLQVTQVSSCKFLSAINPIETPHISVALTFKETEEGTLQLQA
                     EGSVKKEAVKKSTVKESTVEENTVKDECFIKLKAALTPKA"
     CDS             6322..7512
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 74.1; E-value: 2.3e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg332_9"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.5e-26,
                     bitscore: 82.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEQISTAYWHEKLKQLGIIVIIPSYNNGKTLADVIESVRFYAPD
                     ILVVNDGSTDETAGILSRESNLHTITHPANQGKGVALRHGLSFAKKQGFRYAITIDSDG
                     QHFASDIPALIEAIEKEPDTLLVGARNLASDNMPGKNTFANKFSNFWFTLETGIKLQDT
                     QSGYRLYPIQRMNVDKWYYTAKYEFELEALVFAAWGGITVKNIPVHVYYPPQEERVSHF
                     RPFRDFTRISILNTVLVLVTFLWIIPRNFFRKLTWKNCKQFFSDHVTHSPESNLRITAA
                     ITLGVFMGIVPVWGYQMLITLFLAHLFRLNKVIAIVAANISIPPMIPFLLYGSYVTGCK
                     VLGDPVNLHLNELSFENVKSVIEQYLIGSVIFAVVCSILAGTIAFILLTACRKKKI"
     CDS             7509..9368
                     /locus_tag="ctg332_10"
                     /transl_table=11
                     /translation="MTQFFIGLYDYFERHKILFYLSLISCVLLMGFFALQVRFEENITQ
                     FFPDTKDSQNTIKVFDNLKIKDKIIIMLSSADTCHRVEPNSLIEAAGQLQQTLTEKAGG
                     KLIKGIFAQVDQSLIQGATDFVYEHLPLFLTDTDYQRFDSLLTDKGIQAVMQKNYTNLL
                     SPAGIALRSYILRDPLGLGSETLKHLQDFQLEANYEIYDEHIFSKDGSTLLMFITPVFS
                     TGSTGKNDELIKILEEELKHVQGESPTIRAEYFGGPSVGVYNARQIKKDTILTSSLALL
                     IIIVFISLVFKRKRSIPLIITPVLFGGLFALFLIFFIKGSISAIAVGAGSAVMGIALSY
                     SIHMLAHQNHVSTVQQLIKEIAYPLTVGSFTTIGAFLGLIFTSSDLLRDFGLFASLALV
                     GTTLFCLIYLPHFLKGQADVKQGRILRIIEKINAYSYEKNKWLVGGILLITVICLFTSQ
                     KVGFNNDMMSLNYEPRHLQQSEEKLLQLFDNDEKTVLFVSVGKDMNQATETYAMTNQKL
                     SALKEQGLIKEYASASQFLISPQEQQKRLKKWKDYWTDEKQQQVREQLETAAAEYRFRP
                     GSFDSFYQWMNQPFGEYHYTAQGDDLSGKLLNEWQTSADSITML"
ORIGIN
        1 atactggcta tccaagaggt tatttctcaa tcgggagccg acttgcggga gccggattgt
       61 accttgttat tatctaccac taaaggaaat atagatttat tgagtgaatt acctgctgac
      121 agtccggttt ttctttggaa aatggcggaa cgaatcggag atttctttgg agcgacaaat
      181 caggtagagg tcatctccaa tgcctgtata tcaggagtct cggcactaat cgtcgctaag
      241 agatggatag aatcaggacg ttacaaacga gtgattgtgg caggtgggga tattctttct
      301 catttcatta ccagcggctt tctatcgttt cgatctgtca gcgcacacct ttgccgacca
      361 tacgatatac aacgggatgg attaagtctg ggcgaagcct gtggagctgt tcttttagaa
      421 actcaaggaa acgcgaatca tattattctc tccggaggag caatcagcaa tgacgccaac
      481 catatatccg gtccttcccg aacaggggac ggtttagctc tagccattaa tcaggcaatg
      541 gaagaagccg gagcactccc cgaagacatt agctttatca atgcacacgg aacagctacg
      601 gtttacaatg atgaaatgga atccaaagcc atacatctgg cgggattagc tgcagttccg
      661 gtgaatagcc tcaagcccta tttcggtcat acattaggag cttcgggcat tatcgaaacc
      721 atactttgca tagagcaact aaaagaagga agatactacg gaactttagg gtatgaaaca
      781 ctcggtgttc ccatgcctat cactgtctat accactcatc agccgatgcc gatgaaatgc
      841 tgcatcaaaa ccgcttccgg tttcggaggc tgtaatgccg cactggtatt atccctcccc
      901 gatgctcacc tgaaacagaa agtaaacttg caggcaaccg acaaagcgag tgctccgtca
      961 gtttgcaaag cagtggtgga atcgggcaac atggtcacaa tcaggccagg agcagtagaa
     1021 agtaaaggaa caactgtatt cagctcttcg gaaactgact ttgcaccgtt catccgggaa
     1081 gcatacaagc atctgggaga aaacaatatg aagttctata agatggacaa cctctgtaag
     1141 ctgggatatg tagctgccga atatttactg aaaaatacac accaccgtcc ggaagagatt
     1201 ggaatcattc ttgccaatgc ttcttcctct ctggatacgg actgcaaaca tcaggcaatc
     1261 atcagtaaag aaggggacaa agcagccagt cctgccgtgt ttgtctacac tctccccaat
     1321 gtagtattgg gagaaatctg tatccggcac aagattcagg gagagaatac attctttgtc
     1381 cgtcggcaat ccgatgctgc ctcattagag gattatgcaa ggattgtgat ggcgaaaggt
     1441 aagttacgca cctgtatcat aggctggtgc gaactgctgg acggacatta tcaagcagaa
     1501 tttaaacaac ttaataatat atcaacgatt tatggataat ttagatcaaa ccaaaagaga
     1561 actgatggac gaagtgaaag ggaaactaat cgaagagttg aaccttgaag aaatcactcc
     1621 ggaagatatt gacaatgaag cccctctgtt tggcgacgaa ggtcttggcc tcgactccat
     1681 tgacgcactc gaaatcatcc tgattctgga acgcgaatac ggtataaaga tagagaaccc
     1741 cagtgaagga aaacaaatct tctactcggt acgtacactg gcagactaca tcattgctaa
     1801 tcgcaaagct taaccgatga agatatacgt caccggattg ggagttgttt cgggcatcgg
     1861 tatcggagtt tccgaaaata tagaagcgtt gagacaaaga aagcatggca tcggaaaagt
     1921 aactcttttt ccgactgctc tcgatgtgcc cgtatccgaa gtgaaacgta gcaatgagga
     1981 actaaagcaa ctgatctctt tacctccgca acgcactgta tcacgtacgg ccttgttggg
     2041 aatgatagca gccaaagaag caatgaaaga tgcgggactc acaccaccat tacgtatcgg
     2101 ttttatttcc gccacttccg ttggcggcat ggatttgagc gagcacttct atgaatcttt
     2161 caagaaaaac ccgggacagg gacggttacg ggaagtaatt tcacacgact gcggagccag
     2221 tacagaattg attgcttcgt atttgggtat caatgatttt ataaccacca tcagtacagc
     2281 ctgctcgtca gcagccaatg ccatcatgct gggagcaaga atgattaaac acgggctact
     2341 ggatgctgct atcgtgggag gtacggatgc actttgccgg tttacgctca atggattcaa
     2401 ctccctgatg attttggaca aaacacattg ccgtcccttt gaccgctcac gtaccggatt
     2461 aaatctggga gaaggtgccg gttacttagt gcttcaatcg gaaagttcac tccaaagaac
     2521 tccttattgc gaacttagcg gttacgccaa tacgaatgag gcttatcatc aaacaggaag
     2581 ttctcctgaa ggggacggtg cctttctgtc aatgagtgaa gctatcgctt ccagtggtat
     2641 ttcccttgaa gaaatcgatt atatcaatgt acatggaaca ggtactcccg gcaatgatgc
     2701 gtcagaaggc atggcgctcc gaagaatctt tggagaacac gttccgccat ttagttcggt
     2761 aaaagctttt atcggacata ccttaggagc ttccgaagga attgaagctg tttactccgt
     2821 tctttcaata gataaagggc tgatttatcc caacctgaac tttacggatg cgatgccgga
     2881 aacaggactg ataccggaaa cctcttttca agaaggaatc cccatccgac atgtgttatc
     2941 caactctttc ggtttcggag gaaacgattc atcgctcctc ttttccgcaa cgaattttcc
     3001 agcataaacg cacctttaag tatttaagcc tatgcagcca gtttatattc aacgcatcgc
     3061 ttccattcat ccgccaaagg atcattcacc aggaaataat cgcccttatc ttcaggcttg
     3121 cgaacccgat tataaggata ttatcaccaa tgcgaccttg cgcagacgca tgagccgtat
     3181 cgtaaaaatg ggggtggctt gcggattgga atgtatgggt gaactatctc ctgaaaagat
     3241 acaaggaatc atcacagcaa caggattggg ctgcttgaca gatacggaaa aattcctgaa
     3301 caacctattg gataatgaag agcggatgct gaatcctact ccttttatcc agtcgacatt
     3361 caatacaatc ggtgcacaaa tagctctgat tcatcaaata catgcctaca acatgactta
     3421 tgtccaccgt gggcttagtt ttgaaagtgc tttattggac gctatgatga aaataggaga
     3481 aggaagcgag aatatgcttg tgggagccat cgatgaaatg acagaaacct gttacacgat
     3541 tcagcaacgg ctgggaatgc tgaaagggat agcagccgga gaaggtgctc aattctttct
     3601 gttaagtcgg gaagccggag agcatccgtt ggctgaaata cagggagtcg aaactttcat
     3661 cgggaaacag acaacagaag aaatcagctc ccgaatcatc cgttttttgc aacgaaatgg
     3721 tttagagtgt caggatattc agtggttggt taccgggaaa aacaagaagc aacacaatca
     3781 agatgactct cacgagcaaa ctgtcgacaa tggcaactct atttatgaag agcttgaaac
     3841 aaacattttc ccggaaagtg ttcatcttag ttttaagaat gaatgtggtg aatatcctac
     3901 cgcaacatcg tatgcggtat ggaaagcagt gaacgaatcg gccaactgca ctacctcgac
     3961 ccatatattg atttataatc atcaccactc catcaatcat tcattgattc taatccggaa
     4021 aagcgtatga taatcgtttg cctccttctt tgcttgctct tgctcctgtc ttttctcgtt
     4081 tatgcctctt atagcattca atcgggaatt tacctccggt cattttgcaa aaagcatact
     4141 gcggaaaaga ttgtcgccct gacttttgat gacggccccg actccctaca gactcccaaa
     4201 gttctgcagg tactaaaaga atatcaggta accgcctgtt tcttctgtat cggtcataag
     4261 gtaaaaggga atgaagcaat cttgcaaaaa atggtggcag aaggtcatct gattggaaat
     4321 cattcgcata cccattccgg tttattcccg ctatacgggc tctccaagat gaaaaaagac
     4381 ttgcaaactt gtcagtgtga actagaacga gtaacttcgc agccggttag tttgtttcgt
     4441 ccgccgttcg gtgtcactaa tccaacgatt gcgaaagccg ttcgacagtt aggatatacc
     4501 cctataggat ggagcatccg tacactggat acacaacaag caccggataa agtccttgcc
     4561 aggattcgga aacgtcttga accgggagcc attattctgt tgcacgaccg gatgccggac
     4621 agcgaccagc tagtgaaaca aatcttggat ttgctgaaag aacaaggata tactgctgtc
     4681 catccggaca aactattggc ataaaataaa aaaggtatga gaactttatt aatatattta
     4741 tcgcttttct tcttgtcaat agcctctatc catgcccaga gcatgaaaaa gatggcgcaa
     4801 aagacagagt ttgaaagccg cctggcaaag gaggcgcaaa ccgtagagtc catcgaaagc
     4861 gattttaccc aagtgaaata tctcgatgta ttcgatgaga aagttacttc caaagggaag
     4921 ttctactacc agaagaccca taaaatctgc atggaatatt tccgcccgat ggattatctc
     4981 atcgtgataa acggcagtaa gctcaaaatc gtttcggatg gcaagaaaag tatcatgaat
     5041 cttagttcga acaaaatgat ggcacagatg caggatatgc tgaccgcatg tatgataggc
     5101 gacctgtcta aaatgtcgtc caactatctg ctggagtatt ttgaagacgc acgatactat
     5161 ctggttaaaa taaaaccgac caacaaagcg gtacaagcct atattgccgg tatagaaatc
     5221 tatctgaaca agaaagatat gtcggtacac aaactccgtc tgtccgaaac agccacaaac
     5281 tatacagaat acgaattcta taataaaaag ttcaactccc tgaagaatga gacgaagttt
     5341 gcgattcgtt agtctgacgg ctctgctatt cttatggata cagatccaga cttcctgctc
     5401 tccacggatg agcggggaag gaagtaccgt gccccccgct atcgaactaa cacaaggaga
     5461 aagctcgcaa aaatacaata tccaactgga tttcatgaaa catcacatga gcggtatgct
     5521 aatagtacgc cgtatgcctg ataacgaaat ccggatcgta gcgtctacct acttcggact
     5581 aagccttttc gatttttctc ttcgcaacga tcagtttact gtcaacagtt gcattgaacc
     5641 catgaaaaag gaaaaggtgc tgaaacttct ggagatggat ttcagacgtc tgttcttaag
     5701 tgggaaagat actcgtgtga aagcgaccaa agacagtgct actgaaaaaa gaaccagtgg
     5761 aaaaggcttt ggaaagtcag tggtctacat cactggcaat actccgggcg atcccgcaca
     5821 aataaaaatc aaacatccgt ggattcggtt aacgatccgt ctggacaaac tatctaaaga
     5881 gatttaatat atgctacttg ataacttcta taccatcctt tcctccgaat catcggactc
     5941 aacgatctgg actatccaga taaagttgaa tcccgggcat cctgtttatc agggacattt
     6001 ccccgaacat ccggtagttc cgggagtttg cctgttacaa cttatcaagg aatgtgtaga
     6061 agatattcgc cagcaaaaat tgcaagtaac acaagtgtct tcctgcaagt ttctttcggc
     6121 tatcaatcct atagaaacac cgcacatttc ggtggcactg acttttaaag agacagaaga
     6181 aggtacactt cagttgcaag cggaagggag tgtaaagaag gaagctgtaa aaaagagtac
     6241 agtgaaagag agcactgtag aggaaaatac cgtaaaggac gaatgtttca ttaaattaaa
     6301 agctgcactt accccgaaag catgaaggaa caaataagta cagcctattg gcacgagaag
     6361 ttgaaacaat tagggatcat cgttatcatc ccaagttaca acaatggaaa gacactggcg
     6421 gacgtcatcg aaagtgtacg tttctacgcc cccgatatcc ttgttgtcaa cgacgggtct
     6481 acagatgaaa ctgccggaat acttagccgg gaatctaact tacataccat cacccaccct
     6541 gccaatcaag gaaaaggagt agctttgaga catggactat cctttgccaa aaagcaagga
     6601 tttcggtatg caatcaccat tgattccgac ggacagcatt tcgcttcgga tattcccgca
     6661 ttgatcgaag ccatagaaaa agaaccggac acattattgg taggtgcccg taacctcgcc
     6721 tcggacaata tgccaggaaa gaatacattt gccaataagt tttccaactt ctggtttacc
     6781 ctcgaaactg gtatcaaact gcaagataca caatccggct accgcctgta ccccatccaa
     6841 cgaatgaatg tggacaagtg gtattacacc gccaaatacg aatttgagtt ggaagcactt
     6901 gtctttgcag cctggggagg cattaccgtt aaaaacattc cggtacatgt ttattatccg
     6961 ccacaggaag agcgggtttc tcatttccga ccgttccgtg atttcacccg tatcagtatc
     7021 ctgaatacag tactggtgct cgtcactttc ctttggatca tcccccgaaa cttcttccgt
     7081 aaactgactt ggaagaactg caagcagttt ttctcggatc atgtcaccca ctcccccgaa
     7141 tctaatctgc ggatcacggc tgccatcaca ctcggcgtat tcatgggtat cgttccggta
     7201 tggggatatc aaatgctaat cacgttattt ctggcacatt tgttcagact gaataaagtc
     7261 atagctattg tagcagccaa tatcagtatc cctccgatga ttccattttt gctgtacggc
     7321 agttacgtaa ccggttgcaa agtgctggga gatcctgtca atctgcattt aaacgaactt
     7381 tcttttgaaa atgtaaaatc agtcatagag caatatttaa taggaagtgt tatctttgca
     7441 gtcgtatgca gcatactggc aggaaccatc gcgttcattc tgctcacggc gtgtaggaaa
     7501 aaaaagatat gacccagttt tttatcggac tatatgatta tttcgagagg cacaagattc
     7561 tgttctattt gtcactcatc agttgtgtcc tgttaatggg attctttgcc ctgcaagtaa
     7621 ggttcgaaga gaacatcaca caatttttcc ccgacactaa agattcccag aacacaatca
     7681 aagtattcga caatctcaag attaaggata agattatcat tatgttatcc tcggcagata
     7741 cctgccaccg cgtagaaccc aactccctga tagaagcagc cggacaactg caacaaaccc
     7801 tgactgaaaa agccggagga aaactgatta aaggaatttt cgcacaggta gaccaaagcc
     7861 tcatccaagg agccacagac ttcgtttatg aacatcttcc gcttttcctg acagatacgg
     7921 actatcaacg cttcgattcc ttactgacgg ataaagggat acaggctgtc atgcagaaga
     7981 attataccaa cctcctctct cctgccggaa ttgcattaag aagctatatt ctccgggacc
     8041 cgctcggact gggaagcgaa accctgaaac atttgcaaga tttccaattg gaagccaact
     8101 acgagattta tgacgaacat atcttctcca aagacggctc caccttactt atgttcatta
     8161 ccccggtatt cagtacaggc agcaccggaa agaacgacga actgataaag atactcgaag
     8221 aagagctcaa gcacgtacag ggagaatctc ctaccattcg agctgaatat ttcggtggtc
     8281 cctccgtggg agtctacaac gcccgtcaga ttaagaaaga taccatcttg acctcctccc
     8341 tggcactgct tatcatcatt gtatttatct cactcgtttt taaacgaaag agatcgatac
     8401 cgttgattat tactccggta ctgttcggag gattatttgc cctgtttctc attttcttta
     8461 ttaaaggaag tatctccgcc attgcagtgg gagccggttc ggcagtgatg ggtattgcac
     8521 taagctactc cattcacatg ctggcacatc agaaccatgt ttccaccgtg caacaactta
     8581 ttaaagagat agcctatccg cttacggtag gtagtttcac caccatcggc gcatttctgg
     8641 gattgatatt caccagttcc gatctgttac gcgacttcgg attgtttgcc tctctggcat
     8701 tggtgggcac caccctcttc tgtctcattt acctgcctca ttttctgaaa ggacaggcag
     8761 acgtcaaaca gggacgtata ctacgcatca tcgagaaaat aaatgcttat tcttacgaaa
     8821 agaataaatg gctggtaggc ggcatcctcc tcattacagt gatctgtttg tttacttcgc
     8881 aaaaggtagg cttcaacaac gatatgatga gtctcaacta tgagccccgc catctccaac
     8941 aatcggaaga aaaattactg caactctttg acaacgacga aaagaccgtg ctttttgtca
     9001 gtgtgggcaa agacatgaat caggctaccg aaacttatgc aatgaccaat cagaagttat
     9061 cggcactgaa agagcaggga ctcatcaaag agtatgcctc cgcctcacag tttctgatct
     9121 ctccgcaaga gcagcagaaa cgcctgaaga aatggaaaga ttactggacg gatgaaaaac
     9181 agcaacaagt ccgtgaacag ctggaaacag ctgccgccga atatcgtttc cgtccgggaa
     9241 gctttgattc tttttatcaa tggatgaacc aacctttcgg tgaatatcat tacaccgcgc
     9301 aaggagacga tttatccggc aagctattga atgaatggca aacctctgcc gattccatca
     9361 ccatgcttat
//
