LOCUS       gnlProkkaJOLAFGDI_53   13814 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JOLAFGDI_53.
ACCESSION   gnlProkkaJOLAFGDI_53
VERSION     gnlProkkaJOLAFGDI_53
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 12:03:21
            Original ID  :: gnl|Prokka|JOLAFGDI_53
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13814
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13814
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3463:3814]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3464..3814
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13814
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13814
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             309..1820
                     /locus_tag="ctg53_1"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEEIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             1893..2960
                     /locus_tag="ctg53_2"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELTSVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPTVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             2997..3281
                     /locus_tag="ctg53_3"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(3464..3814)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_4"
                     /sec_met_domain="PqqD_RRE (E-value: 1.4e-10, bitscore:
                     34.6, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.2e-17, bitscore: 55.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETVVLSFSRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(3912..5300)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg53_5"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(5548..5943)
                     /locus_tag="ctg53_6"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             complement(5950..6723)
                     /locus_tag="ctg53_7"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(6729..7256)
                     /locus_tag="ctg53_8"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(7243..8484)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 391; E-value:
                     1.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg53_9"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLAQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(8494..9588)
                     /locus_tag="ctg53_10"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(9593..10633)
                     /locus_tag="ctg53_11"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQNQIPLGEASKE
                     AEQTNK"
     CDS             complement(10652..11662)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_12"
                     /sec_met_domain="PF04055 (E-value: 2.8e-17, bitscore: 57.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVELQSLTKRLGMPSFAAKQIASWLYEKKVASIDDMTNLSLKH
                     RELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGC
                     KMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALE
                     LLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAF
                     SITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAI
                     PGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
ORIGIN
        1 gggcaggaat taaactactg agagcgaaga ttatttattc acaatagaag aagtaccacc
       61 aaatttgacg aagaaccaga aatctttttc agggagaaat aaaagtaagt tcataatggt
      121 gcagcattga attatttttt ggcggagtta ttctaacact taatagttca aaagcagata
      181 tttctttgac caaaagatag aactaatgat gaattaaaag ttgcaattat ggttttcttc
      241 ccacaacaaa cgggaaaagt cagaagaatc atgtacattt gtaatccgaa aactaaaaga
      301 acatcgcaat gaaaatattt ccaagcagca gtatcaagaa attggacgct tataccattg
      361 agaacgaacc tattgcatca atcgatctga tggaacgtgc agcaaccgta ttaacaaaag
      421 ccatcacaga cagatggaat acggaaacgc cggtcactat ctttgccgga ccggggaata
      481 atggcggaga cgctctcgcc gtagcccgca tgatggctga aaaaggatat aaaatcgagg
      541 tatttctctt caacacgaaa ggagaacttt cacccgactg ccagaccaat aaagaactgg
      601 tagaaatgat ggaagaagta aaattccacg aaatcagtac ccaattcgta cctcccgtcc
      661 tgacgcccga tcatctggta atcgacggat tattcggttc aggcctgaac aaaccgttga
      721 gcggtggatt cgctgccgta gtgaaataca tcaattcctc ccctgccatg gtagtagcca
      781 tcgacattcc ttccggactg atgggagaag aaaatacatt caacgtaaaa gctaatatta
      841 tccgtgccga cgtaactttc agtctgcaac tgccgaagct cgcctttctt ttcgcagaga
      901 acactgaatt tgtcggagaa tgggaagtgc tggatatcca attaagcgaa gacggtattg
      961 aagagatgga gactaactac gaaatgttgg aaatagaaga aatccgttca ctcatcaagc
     1021 cacgcaaaca gtttgcccac aaggggaact tcggccatgc actattgatt gccggttcaa
     1081 aaggaatggc aggagcctct gttctcgctg cccgcgcctg cctccgttcg ggagtagggc
     1141 tgctgactgt tcatgcgcca atgtgcaaca acgacatctt gcagacctcc atacccgaag
     1201 caatcgtaga aaccgacatc aacgaaacct gttttgccgt acctaccgac acggacgact
     1261 atcaagcagt cggcatcggc ccgggactgg gacgaaacga ggaaacggaa gctgccttat
     1321 tggaacaact ggaacactgc cagactcctg ttgtagtaga tgccgacgct cttaatatcc
     1381 tcgccaacca ccgtcatgcc cttacccacc tgccgaaggg ttccatcctc accccgcatc
     1441 caaaagaact ggaacgtctg accggcaaat gccaggactc ttacgaacgt ctgatgaagg
     1501 cttgcgaact ggcccgtgcc gcccatgtcc acattatttt aaaaggagcc tactccgcca
     1561 tcatcacccc cgaaggtaaa tgtttcttca acccaaccgg aaatccggga atggcaaccg
     1621 gaggtagcgg tgacgtactg accggagtaa tcctggcgct gcttgcccaa ggttatccca
     1681 ccgaagaagc cgctaaaatc ggcacttaca ttcacggatt ggcgggcgat gtcgctcaaa
     1741 agaagcaagg aatgatcgga atgatcgcaa gcgatattat cacctgtctg ccgacagcat
     1801 ggcgacttgt aagcgaataa aagttaagaa cttacagttt tttcaataac ttcattaact
     1861 ttgttttcaa aaccagttaa aaagaaccga atatgaaaaa gttgattata gcagcaggac
     1921 tacttatgac aacgtccgcc tatgcacaaa ccgaagtact gacaggggtt acccgaggaa
     1981 aagactatgg agtggtttac agtcttccca aaacccaaat agaacttgaa ataaaagcca
     2041 acaaagtcaa ctatactccg ggagaattca gcaaatatgc tgatcgttac ctgcgactga
     2101 ccaacgtctc cgccgaccct gaagagtact gggaactgac tagcgtaaaa gtgaaatccg
     2161 taggtgtgcc caacagcgaa acgacgtatt tcgtaaaatt gaaggataag acagtagcac
     2221 cgctcatgga actgacagag gatggcattg tgaaaacgat caatgttcct tacagcaaca
     2281 gcagtgtagg caaaaaagcc gctcccgctc ccacagtcct ccaaaagaaa gcaaatcctc
     2341 gtgaattcct gaccgaagag attctgatgg ctagctctac cgccaagatg gccgaactgg
     2401 tggctaaaga aatctataac atccgcgaaa gcaaaaatgc cttattgcgc ggacaggctg
     2461 acaatatgcc ttcagacgga gcacagctta agattatgct cgacaatctg aatgcacagg
     2521 aagaagccat gacgcaaatg ttctccggca cctgcaacaa ggaagagaga acattcactg
     2581 tccgccttac ccctgacaag gaattcaaca atgaagttgc tttccgcttc tcgaagaagt
     2641 taggtgtagt tgccaacaat gatttggcag gaactccgtt ttatatcagt ctgaaagacc
     2701 tgaaatcggt caagatacca caggaagatg gtaagaagaa gaaagatttg gatggaatcg
     2761 cctacaacgt acccggacaa gctatggtta cattgaccga cggcaaaaag aaactttacg
     2821 aaggtgaact tcctattact caatttggtg tgatagaata tctggctccg gttttgttca
     2881 acaagaattc taccatcaaa gtttattttg atccgaatac gggaggattg ctcaaagtgg
     2941 acagagaaga agggaaatag aaaaacgaga aagtgaactt ctaaaaaaca aagaatatgg
     3001 ttggtgaagg acatgcattc gacatgatac gccgaataaa agagggacgg gaagcttccc
     3061 gcctacgtcg tgaacgtgct aacgacaagt tgaagcattt aaaccgtgca aacgaacctt
     3121 atccactacc caataccact cccgaagaaa tggaacgtat catccacgac tcggagaaaa
     3181 agaaagagaa agacagcaat tattttgttt ggggaacgct tattatcatg ggagtcctga
     3241 tagcaattgc cgtcatactt tgggctgtat ttatcaaata aataataata aattcaccac
     3301 agaggacacg gaggacacag aggtttaatc ttttttattc actatagagt aacacagagt
     3361 ctcacgtatt gagaatcgta tttatcgctc tgttttactt gcggaaagag agagaagaac
     3421 tctgtgtcct ccgtgtcctc tgtggtgaaa tataaattcc tatttatgcg actggtatca
     3481 ccagttttat aaatccatct ttctgcattt gagaaagata agccgataca cgcgactcgt
     3541 agccctcttc attttgaaaa tggtctgcga gtttttctat aatctcacga acattgcgtt
     3601 ttccatctat cagttcccat acagccgtac cgtgttcttc caatttcaca tgaagttctt
     3661 tcgacattcc tttcggcaca aggaagcgtt gcatccacgg atatttaaaa cgggaaaagg
     3721 agagcacaac tgtctcccct tccctttctg ctgtaatatg ttcactgcga cagggaatga
     3781 cctctaacag gttgattttc tctttggcag ccatacttct tattttttat ttcagagtat
     3841 tcatactgat actcttctgt ttacaccttg atacaaaatt cctttgttac tttaggtatt
     3901 gaatttccca gttacttttg gatattcgcc tcttccaaac cgtatccctt cttcttgttc
     3961 tctgccttca acatcaaagc cacaatcaga gcaagcacac caaaaagagc aaaaatagtc
     4021 atcggcaacg tgtagtcata agtctgtgca ccgtctacta ccggaccttt gcaataagta
     4081 ttcaacaccc atccgatcaa caaaggaaca cccatcaatc cccagttctg tacccagaaa
     4141 atcaatgcgt atgcggtacc caactgtttt tccggaataa tcttcggaac agacggccac
     4201 atagctgaag gcaccaacga gaaggcaaat cccaatataa tcatgatgat agtagcaaac
     4261 caccatatat tcagtatagg cagagcgaac atcgtatgca caaaaataag catcactgat
     4321 ccgattatca tcaacgtagc tcccttaccg atacggtcat aaagcgagcc gaacaacgga
     4381 gtcaggataa tcgcaccaat cggcaacaat ccgggaatcg ttcccgccaa cttcggatct
     4441 acattatact tctgcaccat caagtcggca gcatacttga taaaggggaa tacagccgag
     4501 tagaacaata cacatagtaa tgcaatcaac cagaatccct tattcgtaat gatatacaca
     4561 atatctttca tacggaacgg ctcttccggc tccaatccct ctgcatccaa agaagcatcc
     4621 aacttcttat catagaaagt ataaaggaag aaagcaatcg tacccacgca caacataatc
     4681 agacaaaaca gaatcggagc aggaatattg gtatggaatg tgccactctc atccgtagat
     4741 ccgaaaaagt cggccaaagg aaccgtgagc accattgcca gagttgttcc gatacgtgcc
     4801 gtagccattt caagtcccat agccaatgcc atttccttac ccttgaacca tttcacgata
     4861 attttggaaa ctgtgatacc ggcaatctcc acacctacac cgaagatagc ataccccaat
     4921 gcagccaggg ttacctgtgt tttgaatccg aagagcatgg caccttccgg aaaagtagta
     4981 gaaatcgcat agtatttcaa tccacaacca aacaccatca ataagcaagc tcccattccg
     5041 gtgaaacgaa cccccatctt atccaagatg ataccaccga agatcagcat caataggaat
     5101 acattaaacc acccgtaagc gcttgtgaag aaaccataat caagactgtc ccatagtagt
     5161 tctttctcaa gcatgggttt tagaggagac attacgtcgg tgaggaaata gccgcatagc
     5221 atagtaaatg cgaccaatgc tagaacactc catcggagta cggcggagtc attcaatttc
     5281 tgtttcaaat gttctgtcat tgttatattt aaaaaagtag ttaataatct tatacagcca
     5341 acaaaggtag ttaaatctcg tttgtttcta tcacaaagag attgttttta caagaaaaag
     5401 ttaagcgcgg attacactga ccacgcggaa cattgaaaat ccgtgtaatc tgcgtaatcc
     5461 gcacttaaat atcaaagaaa tgcagcatcc gtctgcacct tcccattaat ggttttaccc
     5521 caaagtctta cctgacaacg gagtgaatta ctctgctgca ggagcaggag tttcagtagc
     5581 cggtgccgga gtttctgtag caggtgcatt ggtagcagga gcttcagttt gcggcgcagc
     5641 cgtacctgcg ggtaagttat acgggttagt ctgttgttct ttctgtgcct gttccaacac
     5701 tgcgtcttta gcaacagcag agcgaggaac tacataagca gtagcaatgc tcattaccac
     5761 catgaagata gctaagcccc atgttgcttt ttccagaaaa tctgtagtct tgcgcacgcc
     5821 catgatggcg ttagatgaag agaaaccaga agcaagtccg cctccttttg agttctgaat
     5881 cagcacgatg aaacacatca acaaggctgc aataaccatt aagataacga ataataagta
     5941 catttttagt tattttgaat tagcgttaat aatcaatttc tccaaaaatc tgatttggtc
     6001 tgcaaagtaa gcattttttt ttggatattt caagcttaat tttttaatta tttcaagagc
     6061 ttttgaatat cgttgctgtt taacatagat ttttgccaaa gtttccgtaa aacagctgtc
     6121 atcttcctct tcttccttca tcgtttcttc ttcggtaagt tcgtccgaag aggttggcga
     6181 agatggcatt tcttctctta aaggtttcat gcagagggga gagtcgctct cgctcttttc
     6241 tataaagtcg tcaatcagtt cgaagccttt gagtttgggc gtttcttcgg ccggctgttc
     6301 cgtggccgga gtctcctcca aaagataaga agtgtaatcc atcgaatagt cgaaactggt
     6361 ccgggcagtc acctcttcgg gtactgtgga caagaaagcg tcgatcaatg ctaatgtgcg
     6421 gtctacggac ggttcgtctt tcagcacctc cgtgagaggt actccctttt tccgtgcctg
     6481 cacatcatag cggtcacctt caatcaaccg gaacaactgc cgtctgtctg caatgtaaag
     6541 aactgctttc cgcagttctc caccgaaact aatatcatgg agaatataca gattcttcag
     6601 atacagcaga cgaagtgact gaaaatacgg atacctcgca agaagattgc gcagttcgta
     6661 caaagtatcc ctattcagcg tctcgggatg ctgaatccat tgttgaaagt taacagaagt
     6721 catttatatt accagtttgc tacagttgca ttaaaaattt ggtcggtgat ctctttagac
     6781 atttcagcaa tcaatccgtc ctgtacggca gtcaacaact gggtagagtc gtaggtacgg
     6841 aacgcagaaa actgttgttc aaagtcttcg gcatgattgg tgttgttgac aaaacgcaca
     6901 ttgacggtga tagtcaactt cgtctccgaa gaataaccgt cggcagatac tgcctggttg
     6961 tactgattgt accctgtgat ttctccgtca atctgcaagt cggcattctg attcggcttg
     7021 agcagttgca gacgggtctg ccgaatgaag atatctttca ggtcctcatt gaatttggtt
     7081 gccaacggag catatacata ctccgacttg atcgggaagt cggctatcga aatggtcttt
     7141 accttatcat aattgataga cgatccgtta aacttatagg aaacagtgca cgcaatgact
     7201 accaacggca agccgaacag taacaaaggg cgtattattt tcttaatcca attcatattc
     7261 ttttattttt ctataaagtg tacgctcgga aatattcaag tccttggccg cactcttccg
     7321 ctttccatga tgcctctcaa gtgccttgcg tatcatttct ttctccactt cgtccagtga
     7381 caaaggagat tcttctacat attcttccgt gtcttgtatg tcatcgtcat ccttgcaaac
     7441 cgtgggctgc atggtgtgaa tgatagcagg taccgaaggt tgatgcgccg tcactaccgg
     7501 agtagtaacc accgttccca tttgccctac ctgccccacc tgtccggcac gttccgccat
     7561 caggttgtgc accatcttct tcagctccgc cacttcctgg cgcatatcaa acagaacaga
     7621 ataaagaatc tcccgttcgc tctcaaagcc tttactctca cgcgttccca tcagcgcggg
     7681 aagacgttgc gtattttgtg caggaagata attctgcaag atagcagcag agatctccct
     7741 gttggtttca atgatagata tttgctcggt gatgttcttc aactgacgca cgtttccggg
     7801 ccacgggtaa gccaacaact ctttcttcgc atcctccgtc aactgaatag caggcatccg
     7861 gtatttctct gcaaagtctg cggaaaactt acggaacaac aaaagtacat cgtcaccacg
     7921 ttcacgcaaa ggcggtatct ggataggcac cgtattcaac cggtaatata aatcttcacg
     7981 gaaacgtcct tctgcaatcg cttgtgcaag attgacgttg gtagctgcca ccacacgcac
     8041 atccgttttt tgtactttgg acgaacctac tttcataaac tcaccactct ccagtacacg
     8101 gagcaaacgt gcctgggtag acatcggcaa ctcccctact tcatcaagaa aaatagtacc
     8161 gccgtcggct tcgccaaagt accctttccg ttcgccaatc gcaccggtaa acgcaccttt
     8221 ctcatgtccg aacagttcgg aatcaatcgt accctccgga atagcaccac agttgacagc
     8281 aatatactgt ccgtgcttcc tccggctata ttgatgaata atctgcggaa aactttcttt
     8341 tccgactcca ctttctccgg taatcagcac agacaaatcg gtaggagcta cctgaatggc
     8401 aacatctatg gcgcgcgaca atgcttcagt atttccaata ataccgaaac gctgtttcac
     8461 ttgttgtatc tctgctctcg tcatcactcg tttttaatct tcgtctactg tatccagctt
     8521 cagtttatca ctatcgtcac gtttctcgta atactgttta cgcaacggat tggcacgagc
     8581 cactttttcc cgctgacgat tacggaacac atcgatggca acatagattg cctgacggaa
     8641 agaatcttca caagccactc ccttacctgc aatatcgtat gccgttccat gagccggaga
     8701 agtacgtact accggcagtc ctgccgtata gttcaccccg tcttccatag ccaaggcctt
     8761 gaacggagcc agcccttgat cgtgatacat cgccaggata ccgtcaaaat gagtataatt
     8821 gcccgaaccc ataaagccgt cggccgcata aggaccgtag caaaggattc ctttctcttc
     8881 catttctttc atggcaggga taatcacttc ctgctcttcc attcccaaca aaccaccgtc
     8941 tccggcatga ggattgagag agagcaccgc aatacgcgga gcgccgatac cgaaatcctg
     9001 tttcagacaa cgatggaata tcatcagttt ctcctgaatc agttctttgg taatcgtagt
     9061 cgcgatctct ctaacaggga tatgtgtcgt caccaaagcc acccggaagt cattcttcat
     9121 caaaatcatc aatgacttat caccattgcc cagacgttct tcgatatatt ccgtatgtcc
     9181 ggggaaggag aactcttccg actgaatcgt atgtttgttg atcggagctg ttacgataac
     9241 gtctatcagc ccttcgcgat attcttcgat ggcacgttcc aaagccccca gcgcagcttt
     9301 accggcttcg ggatcgggtt tggaaaattc cactttcacc tcatcatccg tacagttcac
     9361 cacgctcaaa cggttgtacc ccgcttcggt agcagagttg acaatactga aattggtttg
     9421 tatatccagc gctttgcgat gataagccgc tactttcggt gagccataaa tgatcggagt
     9481 acatagttcc aacatcgtag ggtcggaaaa tgtcttaaga atcacctcat agcccacccc
     9541 gttaatatct ccttgggtga tacctatcct tatcttgtta tcttccatgt ttttatttat
     9601 tagtttgttc cgcttcctta gatgcttctc ccaatggaat ctgattctgc tgaacttcat
     9661 tcggaagttt cagtgtatac agagatgctt ccatctggcg taccaggttg cgtttcattt
     9721 tatcaggtga ataaacaaat atttctgctg ttataattcg ttggtttttc tcgtccagac
     9781 gagtatgaga tacatacgga ccacccataa agtcgccctt catacgccac aggccacgtg
     9841 cttccattgt gtagctgttc tgtacattga tcggacggac atcggtcagc aaactatcgg
     9901 tcgacatata aacgccctcc ttgaatccgg gaatattggc tttcatcacg gagtcacgtt
     9961 tgtgcacaaa atattctttg gtaaacgtat ccttgtcagt gtacggataa gagtacatca
    10021 caaagttacg gtcggcagta cctgtgttgg tagaagccca gaagaaatca tccccggtct
    10081 ttgaattagc cagttcggca tccacccaga tgtcgcatcc gaacaaactg tccactttct
    10141 gcgaaatgaa gttactgtgt ttcccttcca ggaacgtaat ctgacggttc atttccgcac
    10201 gggtaaagaa gtcgacaatc gtctttttgt tctcttccac aaacttctca aactcttctt
    10261 cgttcggagc ctggatagtc aatatcatct gcggattggc atacacgtcc ttcgcatatt
    10321 tgaacgaggc tttcgtatat atatcctgta tatctacaat aataatgtta cgtatcaact
    10381 tcagcgtaga atcataatct ttcggcgaag tatacataat ccggaaagaa ggttccgact
    10441 gcggcaaacc gggcatatca gcatcgagcg catcatgtaa agcccttccg gcagcacgat
    10501 cccaaacacc gtgatctact acaaccaaaa gctcgtaagc acgaccacta gaggtgtgat
    10561 ttcctttcag accacaagat gcaacgacaa aggctaccaa agcgatgcat aaaataaaag
    10621 agtacttttt catgatgttc ggttttatat attaactttc attatttttc tcctgtttcg
    10681 ctgtcgacag cataccgcaa gcggcaaaaa tatcttcacc cctggatgaa cggatagtgg
    10741 tgaaaagtcc gtgtgacgtc agataatcac gaaaacgggt catcgtatcc atatccgccc
    10801 cctcgaggtc tacccccggt atggcatgaa aacgaatcag attcaccctg caatccagcc
    10861 cgcgaagaag tttcagcaac tctttggcat agacctgcga atcattgagc cctttaaaaa
    10921 caatatattc aaacgaaagt cgacgttgtt tactaaaatc atagtttttt aacagttcca
    10981 ccatttcggt gattgaaaac gccttttccg ccggcattaa ttcagcacgc tgaacggtca
    11041 gcggagagtg aaggctgatg gcaaggtggc agtcattttc ttcaataaaa cgctgcaatc
    11101 ctttccgtag cccgacagta gaaagcgtga tacgcttcgg actccatgcg taaccgtagg
    11161 tagcggtcag tagttccaat gctttcaata cctcatccag gttatcgagc ggctcgccca
    11221 ttcccatcat tacgacatta gtcagtttgt cccgttccgg cagcgaatga atctggttta
    11281 tgatctggct ggcggtcagg ttagccgtat acccctgttt gccggtcata cagaacttac
    11341 agttcatctt gcaacctact tgtgacgaca cacacaacgt tgcccggtca tcatccggta
    11401 tataaaccga ctctacaaaa tggttctcac ccactttata aagatacttc accgtaccat
    11461 ctacagagcg catttcatct accggagctt ccgctcccac ctcatagttc tgcttgagca
    11521 actcccggtg tttcaatgac aaattagtca tatcatcaat cgaggctacc ttcttttcgt
    11581 aaagccagga tgcaatctgc ttggcagcaa agctgggcat acccagtctt tttgtcaatg
    11641 attgaagctc tacaagagtc attcctaaaa ggggatattt agacattctt ctttctgttg
    11701 atagtttata tctgcaaatg taaggaaata aagtcgattt ccgtatagca ggaatgtaaa
    11761 agttaacaaa aaagggaagt atgcctccgt tatgattcaa ccacgctgat atattgaagt
    11821 agcttttgcg ccatttcaga atcctcgcca ttctttttca cttcataacc gtacgcctca
    11881 cggaaacaag ccagcgcctc ttcccgttca ttacaaaagc tgtgcaaaac ccctaagttc
    11941 tgacaagcca gaatcgtatc ttcttcctcc catcccaaat acttctttcg cagttcaagt
    12001 tctctgaaga aagcctcttt cgccattgga taattctcca acttcacata agcctgtgct
    12061 ttgtaataat ataccagaca ggaagcatta gggtcagcat catcgtgaaa atccaaagac
    12121 gttgcaatac gaatcacgtt atcatagtct ttattcatgt aatactgctg cataatatca
    12181 catctcaatg cttcatagcg gacagtcagt tccgccagac gcggtttttc gctgaaatac
    12241 atttcatgca gaagagactc acggaagaat aaagtagacg cctgctcatc gccacgttca
    12301 ttcatcatcc gtttgaattc cctgcataga taatacaact gtttatgaca agcgacgatc
    12361 tgttttttgc tgtctatctg tatagcaatg tccaacgcct gattcatcag catccatgct
    12421 tcatcgtatc gtttgatata ataaagacat ttaccctgca tacgcaaaca tttagccact
    12481 ccaccggaca gcctaccatt caacgactcg tgcatttcag ctactttccg gaatttctcg
    12541 gcagcactct cttcctcatc cttatagtaa tcacaataag ccagatattc ggaaagttca
    12601 atgacttctg cctgactctt ctcgtcagca gaagccgcat gataatcaag cgccctattc
    12661 agataggtca ctgcttcatt gtattgctca ttgtagtaat atgccagagc tagatttcgg
    12721 caggtgttgg caatctccag ttccggagtc ggtactatgt tttcctgcat caccaatgct
    12781 ttcaggaaac agtcgcatgc cgtttcgtat tcttcattac gggcatatcg gcatccctca
    12841 ttcatcttca ataccgactt ggcaatgagt ggcatagcag caccttccat actcttctca
    12901 ctcacagcag ctgccgcctt cgtcagatgg aaagaactgc tcaagaaagt agccatatca
    12961 ttagcaataa caggaattaa aaaagaatcg atctcatcaa agtccaattc ggcatagact
    13021 tcaggcgtaa cttcaggatt gtcgttcatg atcgctttcc agctatcttc caacaaagaa
    13081 cgattcgtgc gatacagaat ctcgaaaatc tccacatcac aaatccaatc cttcaatata
    13141 tcccattctt gcatcttata gcattgatag gtaatctcca ctttatagcg atacgaatca
    13201 tggtagcaga actgtttcat gcgatagtta taatcggcaa aagtcaacgg atgggaaagg
    13261 atttcttcct catccagcag agcggaaata atttcatggc gactatcatc tatacattcg
    13321 tcatcttgag cgaaatagcg ttcgatcgcc tctaccattt gtgtgtcacc aatgcaatat
    13381 cgtcctcctt tgttggtgag ccagctgctc atttccactc tcaactgcga ccaaagtatc
    13441 tgattaatgt ctgccatgct cttcacttca tcttcggtaa atccttctaa agtaagtgaa
    13501 agcatcagaa gcgttcttcc aatctcttcg gaaccataat cagccgacaa acgccgtagc
    13561 acactgtcat agaattgccc aacctcattg agccggcaat atccacgcat atattcattg
    13621 agagcatcgt actgaccgaa cgaaaccagc tcgttgagca atacacttaa acagcgcggt
    13681 tgtttagcca gcacccacga agcaagaata tcttcctgct gtgcagacaa agccttggag
    13741 taagtagaca aatattgctt tgagaacgac ttggcatccg cctgtgaaaa gccattcaac
    13801 tggaaatgag cgta
//
