LOCUS       gnlProkkaOGGHEABL_104  13623 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OGGHEABL_104.
ACCESSION   gnlProkkaOGGHEABL_104
VERSION     gnlProkkaOGGHEABL_104
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 12:06:41
            Original ID  :: gnl|Prokka|OGGHEABL_104
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13623
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..144
                     /locus_tag="ctg81_1"
                     /transl_table=11
                     /translation="MIKEGEVLSADNMTVKRSTVGLKASLWDLVNGRIATCNYAIDEPI
                     II"
     protocluster    1..13623
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[7483:12959]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7484..12959
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..13623
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13623
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             160..855
                     /locus_tag="ctg81_2"
                     /transl_table=11
                     /translation="MNILVIIPARGGSKGIPHKNVKELNGKPLICYSIDAARQLTTDEN
                     ICVSTDDDVIIKVVEDYGLKVHFKRPAELATDCAGTNGVLLHALEFYEKQGRKYDVVVL
                     LQPTSPFRETKSLKEAVALYTSDIDMVVSVKEAATNPYYNSFEEDAEGLLVISKGDGTI
                     ERRQDAPKVWEFNGSIYVINSTRLKEVGLSKLNRIRKYVMDDLHSIDIDSMFDWYMAEK
                     VISSHLIEN"
     CDS             861..1901
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 143.5; E-value:
                     1.3e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.1e-12, bitscore:
                     38.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCSHIILQSFSIIDAIRCINEIHNEPLVLFVVDENKRMQGTLTD
                     GDVRRALIKGIDVDAPISEAMHRNFNFLRRGVNDRVEDIHHQRDLRMRLVPILDEENHI
                     CEIINLEHYVTKLPIDAVLMAGGKGERLRPLTEKTPKPLIKVGDKCIIDYNIDRLLSYG
                     LNHISVTVNYLGDQIEEHFREERDGVKIVTVREPKYLGTIGSIKFVETFYNDTVLVMNS
                     DLFTNIDFEGFFLHFCQHDADMSVAAVPYVVKVPYGVFNLKGREIKGVTEKPTISYYAN
                     AGIYLIKRKLLDLIPDDIFFNATDFMDKLIEQGYKVIRYPISGYWLDIGQHDELARARE
                     MVKHLK"
     CDS             1921..2874
                     /locus_tag="ctg81_4"
                     /transl_table=11
                     /translation="MYKIAVIGAGQLGSRHLQGLKLSKLKSDIWVVDNNPNSLQIAQQR
                     YEEGEVNSNQTIYYIQLIDQLPAELDLVVIATSSKPRLTILKSLLAKVKVVNIILEKFL
                     FTGLADYDEAAQLLQINHVNAWVNCPRRLFGFYAEIDSMIDKQKPLVMEYADSNWGLCC
                     NSIHMIDIFMMLSGEKAYIADFSGIIPQVKDSRRNGYIEFDGIVNVSTPNGSTLRLTCV
                     DDDTVQHQMTIINGSHHIIINEPEGFMSVDGNKQPVHIKYQSQLTGVVADEILLNGNCK
                     LTTYAESSNYHKVFLKGILGVYNKVTGDMHDRCPIT"
     CDS             2895..3830
                     /locus_tag="ctg81_5"
                     /transl_table=11
                     /translation="MIWIIGTGTIALEYAKILDQLEHEFIAVGRSGKNADEFIEAGAKE
                     VVSGGLNNYLAASPTTPQKVIVATNVDQLAEVTVSLLNFGIKDILVEKPGFCRPEEITP
                     VVQLAQAKNAHVLLAYNRRFYSSVLAAEKIIKEDGGITSFNFEFTEWGHVIETLDYSHN
                     IFDNWFFANSSHVVDLAFFLGGEPQEISCFSAGELSWHKPAVFSGAGITNKGALFSYQA
                     NWNAPGRWVVEVLTTKHRLYFKPMETLQIQEKGSVAIKPVEIDNQLDIDFKPGFYLQTK
                     AFVEGDYGRFCTVEKQMKHINTIYKKIVEK"
     CDS             4168..5178
                     /locus_tag="ctg81_6"
                     /transl_table=11
                     /translation="MHLLICNSNMFIPIVLTTVLNNSDQRYLIYVDIPSIYMFFDKLNL
                     PENCNLLKYPHYINWKNANKAKQFIWNQLEHIDIKSITFYHTAYGELATWLISKYSRNT
                     TIYFQSPFPSFCFKKRISLKALKLFLVYKIIYNTDIIPMDSGNNTLPSISPKFFKKNNV
                     INKNAMVDNDLVCNYVNEKLNLNNNNRSILLVTGSNITAGFCDETDYGKIINSILSALG
                     KDKFMVKCHPRFDDLLSIEKMLPAIPKYIPGNVILPLFDCYIGLCSALLIEAANVGKCS
                     ISILNLLNIDFKLKSVLKDSLEVRLKSGSTIYYPNSISELNDIVKRSCNNNITMI"
     CDS             5180..6625
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_7"
                     /sec_met_domain="Polysacc_synt (E-value: 1.3e-22, bitscore:
                     70.5, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRAKQLGKNTLLVFIGSFGAKIISFIMLPFYTRWLSVTDYGVVD
                     MISIYQSLLTDFLTAAISTSIFIFPKGVAFHRQKEYFSSGLIFAFFAFIVAALLFYIVR
                     SSFNLFSVSNSFTDYTVWIYIMIFITFIQTYLQQFCRSIDKMYVFTLIGILLTLCTGIF
                     SFIFIPKNGVYGYLIAMVLSNVVVAITTFFIAKLYKYVSLKSFNKVSLKEMLKYSIPTI
                     PNVLMWWVLGSLNRPILEGTVGLSGIGILAVAQRFPNAASLVFSIFGNSWQISVLEEYK
                     MNDFPLFFNRVLAIFSIITCLGVLILSYISDWLVTFIVGNNFLSSSTYIPCLSLALFFL
                     CMNTIISPIFSAVRKSKYYLYSSIWSAVLTIGLNILLIPLIGIMGACISIVCSHALMTL
                     LRVKYTLIFVSVYLKEQYLFLGLLAVAFIVALSIGDSLMFRTMALLVAFLGVALVIRNF
                     DKRLNIKFLAIKLFKNKIKFKQS"
     CDS             6622..7473
                     /locus_tag="ctg81_8"
                     /transl_table=11
                     /translation="MITLRGLFRDLKFLIGCFVYLVKHYSLFSGLKFQGRQERIVYLLC
                     NGPSLKNDMETIKKLKGVDFIVVNFMANDSLFWEIKPQYYTLMDPLFFTNRRENRYMER
                     LEVLFDSFNRIDWEMIIFLPIQYEKSFREFSKINNPKIKIMVLNTFSSYVASDNVRHFC
                     YRKGYAMPNAQTVAIESIFAMLNMGYSTIYLYGVDHTFLEGLKVNDKNELVHVYQHFYE
                     NEPKIIPVTDAFGYHNSLTKELQTIVNIFASHEQCRKYADHLGANIYNLTKGSQIDSYE
                     RR"
     CDS             7484..8995
                     /NRPS_PKS="Domain: AMP-binding (16-408). E-value: 9.2e-71.
                     Score: 230.4. Matches aSDomain:
                     nrpspksdomains_ctg81_9_AMP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     210.7; E-value: 5.1e-64)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_9"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-74, bitscore:
                     241.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNFKIDVLERLSTKMAKYLDQNCFCIKDKYYTYRELSILTAKIQ
                     QEIRNQYTETTPVGLVNNDDIYTYASILALWYEGLAYVPLHPLQPIARCIDIIEQVNIQ
                     LIIDSTEMSRYVDKYNVLYPQNNSNTDVVFPVINNIDDEALCYILFTSGSTGKPKGVQL
                     NRRNITSFVAAFENAGIVLSHEDRCLQCFDLTFDVSVQSYLMPLLNGACVYTLPLDCMK
                     YACSADLIERYKLTFGAMAPSMVRFLKPYFDELDMSSLKKCILTAEASNLSLVKDWKKC
                     AYNAELYDFYGPTEATIYCTYYKLPDDINQTKNRNDILFIGKPMSGIKAVLISPDGIVL
                     NKGIGELCVAGEQVTPGYWQLFEKNKEAFLTISIDNKDYRFYKTGDLCQFDKDGDLEYI
                     GRIDFQAKVQGYRVELGEIECKIREFTKCDTVVLAIKEDNNDDILVGFVESRLVDEKQV
                     YVYLREQLPPYMIPKSIISLAQFPLNNNGKIDRKQLIEIFKTHNK"
     aSDomain        7532..8707
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg81_9_AMP-binding.1"
                     /evalue="9.20E-71"
                     /label="ctg81_9_AMP-binding.1"
                     /locus_tag="ctg81_9"
                     /protein_end="408"
                     /protein_start="16"
                     /score="230.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AKYLDQNCFCIKDKYYTYRELSILTAKIQQEIRNQYTETTPVGLV
                     NNDDIYTYASILALWYEGLAYVPLHPLQPIARCIDIIEQVNIQLIIDSTEMSRYVDKYN
                     VLYPQNNSNTDVVFPVINNIDDEALCYILFTSGSTGKPKGVQLNRRNITSFVAAFENAG
                     IVLSHEDRCLQCFDLTFDVSVQSYLMPLLNGACVYTLPLDCMKYACSADLIERYKLTFG
                     AMAPSMVRFLKPYFDELDMSSLKKCILTAEASNLSLVKDWKKCAYNAELYDFYGPTEAT
                     IYCTYYKLPDDINQTKNRNDILFIGKPMSGIKAVLISPDGIVLNKGIGELCVAGEQVTP
                     GYWQLFEKNKEAFLTISIDNKDYRFYKTGDLCQFDKDGDLEYIGRIDFQAKV"
     CDS_motif       7919..7972
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg81_9_0001"
                     /evalue="1.80E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg81_9"
                     /protein_end="163"
                     /protein_start="145"
                     /score="26.6"
                     /tool="antismash"
                     /translation="CYILFTSGSTGKPKGVQL"
     CDS_motif       8513..8590
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg81_9_0002"
                     /evalue="1.50E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg81_9"
                     /protein_end="369"
                     /protein_start="343"
                     /score="23.8"
                     /tool="antismash"
                     /translation="IGELCVAGEQVTPGYWQLFEKNKEAF"
     CDS_motif       8675..8740
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg81_9_0003"
                     /evalue="3.40E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg81_9"
                     /protein_end="419"
                     /protein_start="397"
                     /score="32.0"
                     /tool="antismash"
                     /translation="YIGRIDFQAKVQGYRVELGEIE"
     CDS             9000..9245
                     /NRPS_PKS="Domain: PP-binding (11-76). E-value: 9.5e-10.
                     Score: 30.8. Matches aSDomain:
                     nrpspksdomains_ctg81_10_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_10"
                     /sec_met_domain="PP-binding (E-value: 2.6e-10, bitscore:
                     30.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERHDIYTSLNQILGKIIGDTKLDLNELTTTDEISGWSSLVQTQL
                     VVEIEKHFNCRLTLRDIMKIDKNISSIVTLIDNKLQ"
     aSDomain        9033..9227
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg81_10_PP-binding.1"
                     /evalue="9.50E-10"
                     /label="ctg81_10_PP-binding.1"
                     /locus_tag="ctg81_10"
                     /protein_end="76"
                     /protein_start="11"
                     /score="30.8"
                     /tool="antismash"
                     /translation="QILGKIIGDTKLDLNELTTTDEISGWSSLVQTQLVVEIEKHFNCR
                     LTLRDIMKIDKNISSIVTLI"
     CDS             9242..9859
                     /locus_tag="ctg81_11"
                     /transl_table=11
                     /translation="MKILSLIRTLKSVLYAYDSDQWEKRVGALGKDSYLRGPISCANPS
                     LIFVGNHSHIFGQANYIIRNGKFIVGDYTGIAQGLTVITGNHISEKGKLFNDCLQLDEQ
                     DVIIEDDVRIGAFVTILPGVKIRRGAIIGAGTVLRFSIPPYAVVTGNPAKIVGFRMNPQ
                     EALEHEAALYPEEKRLSADELFDNYEKYYFNRMSEIIEYLKV"
     CDS             9871..10551
                     /locus_tag="ctg81_12"
                     /transl_table=11
                     /translation="MKITAVIPIRSGSQRVKDKNLRAFADTNLMELKIKNLLQVPELTS
                     IVVNTNSELAIEIVNKSYRGVTTHRREEYYASSQCSGSEFFRHLGEVTDTDLFVYCPCT
                     SPFIKPETVSQCINQFISTSDYDCLATVSSVKEFLWLDGDPMNYDPAHAPNSQDLPDVV
                     ALNFGVTVVRKEDLIKNSNIIGKNPQFVKTSDIESIDIDTPLDFYIAEQLYKKLVIEKK
                     RLLE"
     CDS             10614..11351
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_13"
                     /sec_met_domain="NTP_transf_3 (E-value: 8.4e-14, bitscore:
                     42.2, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKIIAIIPARYQSSRFPGKPLADIFGRPMIWWVYNQVIKVKEFL
                     EVYVATDDQRIADVCSNYGMKFIMTQSNHPTHVHRIHEVSDNIAADYYVVVCGDEPLIS
                     PDIIEAVFPSQDVDNSHMYVGGLCRYFTEPAEVIDPANIKIVTNDSDECVLLSRAPIPF
                     PYKTVLFKYKKVVGVECYNKQALDFFVSTPKGYLENIEDVTLQRFLENKIHIKYKLVDS
                     VSLSVDTPRDLEKVKEIMVTKQA"
     CDS             11355..12959
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 58.9; E-value:
                     7.9e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_14"
                     /sec_met_domain="HMGL-like (E-value: 3.8e-22, bitscore:
                     69.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKVLMLDCTLRDGGYVNDWDFGHSTITGIYKRLEAAGADYIEV
                     GFLDDRREFDINRSIMPSTEAINKIFGSVKKGKAIPVAMIDFGTCSLDSIGSCDSTFID
                     GIRVIFKKEKIDQALPFCKAIKEKGYKLFIQAISITAYSDIEMLEYVNRINEIKPYAFS
                     IVDTYGLLDNSSMARYFYLIDNNLDPSIKMGYHEHNNFQLGFSNTIKFLEKSTKRTLVA
                     DSTVYGMGKSAGNCASELLAMHLNEYYGGHYDLNQLLEIVDTDLMPIYQKHYWGYKYDF
                     YIASMQRCHPSYVQYLLKKSTLSVSSINEILSSIPEEIKLLYNKQWIEQAYLDYQNRAK
                     DDTEALQQLKVELEAASDKPVLIIGPGNTVKEQKKGVELFISGNDPVVFSVNFYTKLYS
                     IDYTFISNAKRYAKFVDIQHGDSIGSKLILTSNVTACDYMPNYVLNYESLLNKESENPD
                     NALVLLLKALIRIGITEVYLAGFDGFTNTPNDYYDRDYELSSTKDESYNDLLSDDLSKI
                     NQSIRLHFITESLYDVR"
     CDS             12946..13611
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115:HAD-superfamily hydrolase, subfamily IA, variant
                     (Score: 117.9; E-value: 8e-36)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_15"
                     /transl_table=11
                     /translation="MMSDKQTIKAVLFDLDGTLLNTSEGIACSVLHTLSVMQLPSISSD
                     EVSTFIGPPIQESLKRHFRLSDEDVQKGADIFRAYYKDCALFKAALYPGIIDLLKQLKQ
                     KGFLIGVATYKREDYAMDILKHFGILEYCDVVHGADNDNKLRKSDIVYLCISEMSVDNS
                     EVVLVGDTYHDLEGAEEADIHFIAVTYGFGFRESVRELSSKNVVGVADNPMEIEGLLK"
ORIGIN
        1 ccaataaagg aaggtgaggt gctctcggcg gataatatga ctgtgaaacg cagtaccgtt
       61 ggtttgaaag cttctttatg ggatttggta aacgggcgta tagctacctg caattatgct
      121 atagacgaac ctattatcat ttaaaaatag acaatagtaa tgaatatact tgtaataatt
      181 cctgcacgtg gtggaagtaa aggaatacct cacaagaatg ttaaggaatt aaatggaaaa
      241 ccgttgatat gctatagcat tgatgcggct cgtcagctta ccaccgatga gaatatttgt
      301 gtttctactg atgatgatgt cattatcaag gttgtagagg attatggctt gaaagttcat
      361 tttaaacgcc ctgcagagtt ggctacagat tgtgcaggaa caaatggagt actgctccat
      421 gctttggagt tttatgagaa acaaggtcgt aaatatgatg tagtagtttt gttgcaaccc
      481 acttctcctt ttcgtgagac taaatcattg aaggaggctg tggctttgta tacttctgac
      541 atagatatgg ttgtttcggt gaaagaagcg gcaactaatc catattataa tagttttgag
      601 gaggatgctg aaggcttatt ggtcatcagc aaaggggatg gtactattga acggcgtcag
      661 gatgcaccta aggtatggga gtttaacggt tctatttatg tgattaatag cactcgcctt
      721 aaagaagtag gtttgtccaa actcaataga atacgtaaat atgttatgga tgatcttcat
      781 tcaatagata ttgatagtat gtttgactgg tatatggcgg aaaaggtaat cagtagtcat
      841 cttattgaaa attaatttat atgaattgct ctcatattat tctccaatct ttctctatta
      901 ttgatgccat tcgctgcatc aatgagattc acaatgaacc actggtgctc tttgtggtag
      961 atgagaacaa aaggatgcaa ggtaccctta ccgatggtga tgtgcgtcgt gccttgatta
     1021 aaggtataga tgtggatgct cctattagtg aggccatgca tcgtaatttt aactttttac
     1081 gtcgcggagt gaacgataga gtggaggata ttcaccacca acgtgattta aggatgcgtt
     1141 tggtacccat acttgatgaa gaaaatcata tttgcgaaat catcaatttg gaacattatg
     1201 taactaaatt gccaattgat gctgtattaa tggccggtgg taagggggaa cgccttcgtc
     1261 cgttaacgga gaaaactcct aagcccctaa ttaaggtagg tgacaagtgt attattgatt
     1321 ataatattga tcgtttgctt tcatacggtt tgaatcatat atctgtaacg gttaactatc
     1381 ttggcgacca gattgaggaa catttccggg aggaacgtga tggggtgaag atagttactg
     1441 tgcgtgaacc gaaatatcta ggtaccattg gcagtatcaa gttcgtggaa actttttaca
     1501 atgatacggt gctggtaatg aactcagacc tctttacgaa tattgatttt gagggttttt
     1561 tccttcattt ctgtcagcat gatgctgaca tgagtgtggc agctgtgccc tacgtagtga
     1621 aggtgccata cggtgtgttc aatctcaaag gacgagaaat caagggcgtt accgagaaac
     1681 ctaccatcag ttattatgca aacgccggta tataccttat caaacgcaaa ttgcttgacc
     1741 ttattcctga tgatatcttc tttaatgcca ctgacttcat ggataaactc atagaacagg
     1801 gatacaaggt gattcgctat cctattagtg gatattggct ggatattggt cagcatgatg
     1861 aattggctag ggcaagggag atggtgaaac atttgaaata aatttgaaat acaatataca
     1921 atgtataaaa ttgcagttat tggtgccgga caattgggta gccgtcattt gcaaggactc
     1981 aaattgtcca aactaaaatc tgatatttgg gtggttgata ataatccaaa ttcacttcaa
     2041 atagcgcaac aacgttatga agaaggtgaa gtgaacagta atcaaactat ttattacata
     2101 caacttatcg atcaattgcc tgctgaatta gatctggtag tcatagctac tagttcaaaa
     2161 ccacgattaa cgattttaaa aagtttactt gcaaaagtga aagtggtcaa tatcatttta
     2221 gaaaaatttt tgtttacagg actggctgat tatgatgaag ccgcacagtt gttgcagatc
     2281 aatcacgtca acgcatgggt aaactgtccg cgacgtctat ttggctttta tgcagaaatc
     2341 gattcaatga tagataagca aaagcctctt gttatggaat atgctgattc taattgggga
     2401 ttatgttgca attctataca catgatagac atatttatga tgctgtcagg agaaaaagcc
     2461 tatatcgctg atttttctgg aattatacct caggttaagg atagcaggcg taatggatat
     2521 atagaatttg atggcatcgt aaatgtatca actcccaatg gaagtacctt acgactgact
     2581 tgtgtggatg atgatactgt tcagcatcag atgactatta tcaatggctc tcatcatatt
     2641 attattaatg agccggaagg atttatgtct gttgatggta ataaacagcc cgttcatata
     2701 aaatatcaga gtcaattgac tggtgttgta gctgatgaaa ttctgttaaa tggtaattgc
     2761 aaacttacta cttatgccga atcgtcaaac tatcataaag tatttctaaa aggtatactg
     2821 ggtgtttata ataaagtgac gggcgatatg catgacagat gccctatcac ataataaata
     2881 taagatgtaa ttatatgatt tggattatag gaacaggaac cattgcattg gaatatgcaa
     2941 agatcttgga tcaattggaa catgaattta tagcagtagg acgtagtggt aagaatgcag
     3001 acgagtttat tgaggccgga gctaaagagg tagtttctgg tggattaaat aattacctgg
     3061 cggcttctcc aactactcct caaaaggtta ttgtagctac aaatgtagat cagttggctg
     3121 aagtcactgt aagtttgctg aactttggta taaaagatat tttggtggaa aaacctggat
     3181 tttgccgtcc cgaagaaatt acacccgtag ttcagttagc acaagctaaa aatgctcatg
     3241 ttcttctcgc atacaaccgt cgcttctatt ccagcgtatt ggctgctgag aagattatta
     3301 aagaagatgg tggaataacc tcttttaatt ttgagtttac tgagtggggg catgtaattg
     3361 aaacattgga ttattcgcat aatatcttcg ataattggtt cttcgccaat tcttctcatg
     3421 tagtagatct tgcttttttc ctaggaggcg aaccccaaga aatttcttgt tttagtgcag
     3481 gggaattgtc atggcataaa cctgctgtat tttcaggagc aggtatcact aacaaggggg
     3541 ctctattctc gtatcaagct aactggaatg ctcccggtcg ttgggtggta gaagtattga
     3601 ctacaaagca tcgtttgtat tttaaaccga tggaaactct tcagatccag gaaaaaggta
     3661 gtgtggctat caagcctgtt gaaatagata atcaattgga tatagatttt aaacctggtt
     3721 tttatttaca gactaaggcg tttgtagagg gagattatgg aagattttgt acggtggaga
     3781 aacaaatgaa acatataaat actatttata agaaaatagt agaaaaataa tgtaagcact
     3841 caaattaata ctcaatttaa aaaaatctat cttcgctgca ggtaaatttt aaaaaatatg
     3901 tattgtaatg aaaatttaga aaggttttgc tttcagtact aaacaaaggc cttttcccca
     3961 tgggaacccc tctagtcgtc ctatgtaaag aataaaattc ctataacact ctaaagtgct
     4021 ctttcggaat ggaatatcct aaattgagcg cttatacaac taaaactatt ttttaattaa
     4081 ttattaatcg atcagttcta tgctttgttc atttttagcg aggtggaaga gtttgatagt
     4141 ttacatttgt agtaaaagat aaataaaatg catcttttga tttgtaatag taatatgttt
     4201 attcctatag tacttactac agtactaaat aattccgatc agcgttattt gatttatgtt
     4261 gatataccta gtatatatat gttctttgac aaattaaatt tgccggaaaa ttgtaatctt
     4321 ctaaaatacc ctcattatat taattggaag aatgctaata aggcaaaaca atttatatgg
     4381 aatcaacttg agcatataga tattaaaagt attacgtttt atcatacagc atatggtgaa
     4441 cttgcaactt ggctaatttc taaatatagt agaaatacaa cgatttattt tcaatcacct
     4501 tttccttctt tttgctttaa aaaacgaatt tcgttaaagg cactaaaact gtttctagtc
     4561 tataagatta tttataatac tgatatcata ccaatggatt ctggtaataa cacattgcct
     4621 tctatttctc ctaagttttt taagaagaat aatgtaatta ataaaaatgc tatggtagat
     4681 aatgatttag tttgcaatta tgtaaatgaa aaacttaatt tgaataataa taaccgttcc
     4741 attctattag ttacaggttc gaatattaca gccggttttt gtgatgaaac tgattatggg
     4801 aaaattataa attctatatt atctgcttta ggaaaggata aatttatggt aaaatgccat
     4861 ccaagatttg atgatttatt atcgattgag aaaatgcttc ctgctattcc taagtatatt
     4921 ccaggcaacg tcatccttcc attgtttgat tgctatattg gattgtgttc tgctttgctg
     4981 attgaagctg caaatgttgg taaatgcagt atctctattt taaatctact gaatatagat
     5041 tttaaattga aatcagtttt aaaagattcg ttagaagtga gactaaaaag tggatctact
     5101 atatattatc ctaatagtat tagtgagctt aacgatattg tgaaacgttc atgtaacaat
     5161 aacataacta tgatataaaa tggggagagc caaacagtta ggaaagaata cgctgttagt
     5221 ttttattgga agttttggcg caaaaattat ctcatttatc atgttgccgt tttacacgcg
     5281 gtggctaagc gtaactgatt atggcgtagt agatatgata tcaatatacc aatcgctttt
     5341 aaccgatttt ctaacagccg ctatttcaac ttcaatattt atattcccca aaggggtagc
     5401 atttcatcgt caaaaagaat atttttcttc aggcttgata tttgcttttt ttgcatttat
     5461 agtagctgca cttctatttt atatagttag atcaagtttt aatctattca gcgtaagcaa
     5521 tagttttaca gattatactg tttggattta tataatgata tttattacat tcattcagac
     5581 gtatttgcaa caattctgta ggagtataga taaaatgtat gtatttacat tgataggtat
     5641 tcttctcaca ttatgtactg gtatcttttc ttttatattt atacctaaaa acggcgttta
     5701 tggatatctt attgccatgg tattgtcaaa tgtagtagta gccattacaa ctttttttat
     5761 agcaaaatta tataaatatg tttctttaaa atccttcaat aaggtttctt taaaagaaat
     5821 gcttaaatac tctattccaa ctattcctaa tgttttaatg tggtgggtgt tgggttcttt
     5881 gaatagaccc atcttagaag gtacagtggg actttctggt atcggtattt tagcagtagc
     5941 gcaacgtttt ccaaatgcag cttcgttagt gttttctata ttcggtaatt catggcagat
     6001 ttcagtattg gaagaataca aaatgaacga ttttcccttg ttcttcaatc gtgttttagc
     6061 cattttttca atcattacat gccttggagt gctcatccta tcttatattt ccgattggct
     6121 ggtaactttt attgtaggca ataatttctt atcttcgtct acttatatac cgtgtctttc
     6181 attagctctc tttttcttat gcatgaatac gattattagt cccatattct ctgctgtacg
     6241 aaaaagtaag tattatctgt attcaagtat atggagtgct gtgctgacta taggccttaa
     6301 tattttgttg attccgttaa ttggcatcat gggagcttgt ataagtattg tttgttctca
     6361 tgcactcatg acattgttga gggttaaata tactttgatt tttgtttctg tctacttaaa
     6421 agaacagtat ttgttcttag gtttgttagc tgttgctttt attgtagcgt tatcgatagg
     6481 cgattctttg atgtttcgaa caatggcact tttagtagca tttctcggcg ttgctctagt
     6541 tattcgtaat tttgataaac gtcttaatat taaattttta gctataaaat tattcaaaaa
     6601 taaaatcaaa tttaaacaat catgataaca ttacgtggat tatttcgaga tttaaaattc
     6661 ctaataggat gtttcgtgta tcttgtaaaa cattactctc ttttctctgg ccttaaattt
     6721 caaggtcgcc aagaacgaat cgtgtatttg ttatgtaatg gaccttcttt aaaaaatgat
     6781 atggagacta ttaaaaagct gaaaggagtt gattttattg tggtaaactt tatggccaac
     6841 gattctcttt tttgggagat taaaccacaa tactacacat tgatggatcc gttgtttttt
     6901 acaaatagga gagagaatag atatatggaa agattggagg tactatttga ttccttcaat
     6961 cgtattgatt gggaaatgat aattttccta cccatacaat atgaaaagtc ctttcgtgag
     7021 ttttcaaaga ttaataatcc aaagattaaa attatggtat tgaatacgtt ctcatcatac
     7081 gttgcctcgg ataatgtaag gcatttctgt tatagaaaag ggtatgctat gcctaatgcg
     7141 caaacagtgg ctattgagtc tatttttgct atgcttaata tgggatatag tactatttat
     7201 ctttatggtg ttgatcatac atttctcgaa ggtttgaaag taaatgataa gaatgaactt
     7261 gtacatgtat atcagcattt ttatgaaaat gaaccaaaaa taatacctgt aaccgatgct
     7321 tttggttatc ataattcact tactaaggaa ttgcaaacca tagtcaatat ttttgcttcc
     7381 catgaacagt gtcgcaaata tgctgatcat ctgggtgcta atatttataa tttgactaag
     7441 gggtcacaaa ttgatagtta cgaacgtaga taaatgagag aagatgaata actttaagat
     7501 tgatgtgttg gagagactta gtacaaaaat ggctaagtat ctagatcaaa attgtttttg
     7561 tattaaggat aaatattata cttatcggga actttctatt ttaactgcaa agattcaaca
     7621 ggagataaga aatcagtata ctgaaacgac tccggtagga ttggttaata atgatgatat
     7681 ttatacctat gcttctatct tggctttgtg gtatgaagga ctggcttatg ttcccttgca
     7741 tcccttgcaa cctattgcta gatgtattga cattatcgaa caagtgaata ttcaattgat
     7801 tattgattct acagagatgt cacgctatgt agataaatat aatgttctat atccacaaaa
     7861 taattccaat acagatgttg tattccctgt cattaacaac atagatgatg aagcattgtg
     7921 ctatattcta tttacttctg gtagcacggg taagccaaaa ggtgttcaat tgaacagacg
     7981 taatattact tcatttgttg ccgcttttga aaatgctggt atcgttttat cccatgaaga
     8041 tagatgcttg caatgctttg atttgacatt tgatgtgtct gtacagtctt atttgatgcc
     8101 tttattaaat ggagcatgtg tctatacttt accattagat tgtatgaagt atgcttgttc
     8161 tgccgattta atagaacgat acaaacttac atttggtgct atggctcctt ctatggtcag
     8221 atttttaaaa ccgtattttg atgaattgga tatgtcatct cttaagaaat gcattctaac
     8281 tgccgaagct tctaatctct ccttggtgaa agattggaaa aaatgtgcgt ataatgctga
     8341 actttatgat ttttatggcc ctacggaagc tactatctat tgtacttatt ataagttgcc
     8401 tgatgacatc aatcaaacta aaaaccgaaa tgatattctg tttattggga aacctatgag
     8461 tggaataaaa gctgttctta tttcacccga tgggatagtc ctgaataaag gaattggtga
     8521 attgtgtgtg gctggtgaac aagttactcc tggatattgg cagctttttg aaaaaaataa
     8581 agaagctttc cttactatat ccattgataa taaggattat agattttata aaacgggtga
     8641 tttgtgtcag tttgacaagg atggagatct tgaatatatt ggaagaattg attttcaggc
     8701 taaggttcaa ggttatcgtg tagaacttgg tgaaattgaa tgtaagatta gagagtttac
     8761 taaatgtgat acagtagtgc ttgccatcaa ggaagataat aatgatgata ttctcgttgg
     8821 ttttgttgaa tcaagattag ttgacgaaaa gcaagtctat gtttatttgc gtgaacagtt
     8881 acctccatat atgataccaa aatctatcat tagtcttgct caatttccac taaataacaa
     8941 tggtaagatt gatagaaaac aattgattga aatttttaag actcataata aataaaataa
     9001 tggaaagaca tgatatttat acttctctaa accagatttt agggaaaata ataggtgata
     9061 caaaactgga tctaaatgag ttgactacta cagatgaaat ttctggttgg agttcactcg
     9121 tacaaactca gttggtcgtt gaaattgaaa agcatttcaa ttgccgtctg actctaaggg
     9181 atattatgaa aatagataag aatatatctt ccattgtaac attgatagat aataagttgc
     9241 aatgaaaatc cttagtttga ttcgaactct taagtcggtg ttatatgctt atgattctga
     9301 ccaatgggaa aaacgcgtag gggctttagg aaaagatagt tatcttagag gacctatatc
     9361 ttgtgctaat cctagtttaa tatttgtagg caatcactct catatatttg gacaagctaa
     9421 ctatatcatc agaaatggga aattcatagt tggtgattat acagggatag cacaaggatt
     9481 gactgttatt acaggtaatc atatttcaga gaaaggaaaa ctgtttaatg attgtttgca
     9541 actggatgag caagatgtta ttattgagga tgatgttcgc atcggtgctt ttgtgactat
     9601 tttgcctgga gtgaaaatta ggagaggtgc tataataggt gccggaacag tattgcgttt
     9661 ttctattcct ccttatgctg ttgttacagg taatcctgct aaaattgtgg gattcagaat
     9721 gaatccgcaa gaagcgcttg aacatgaagc ggctctttat ccggaagaaa aacgcttgtc
     9781 cgcagatgaa ttatttgata attatgaaaa gtattacttt aatcgaatga gtgagataat
     9841 agaatatcta aaagtataaa atacaaaata atgaaaatta ctgccgttat tcctattcgc
     9901 agtggatcac aacgtgtcaa ggataaaaac ttgcgtgcct ttgcggatac taatttgatg
     9961 gaactgaaaa ttaaaaatct tctgcaagtt cctgaactta catctattgt tgtaaacact
    10021 aattcggagt tagcaataga aattgttaat aaaagttatc gaggggtgac tactcaccgt
    10081 cgtgaagagt attacgcctc ttcacaatgt agcggaagtg aattttttag acatttaggt
    10141 gaagtgacag ataccgatct ttttgtctat tgcccctgta cttcgccctt cattaaacca
    10201 gaaactgtat ctcagtgtat taatcaattt atttctactt cggattacga ttgcttggct
    10261 actgtttcgt ctgttaaaga atttctttgg cttgatggtg atccgatgaa ttatgaccct
    10321 gctcatgcac ctaactccca ggatctccct gatgtggtgg cgttgaattt tggtgtaaca
    10381 gtagtcagga aagaagatct tatcaaaaac tccaatatca tcggtaaaaa tcctcaattc
    10441 gtcaagacaa gcgatattga gtccattgat attgatactc ctcttgattt ctatattgct
    10501 gagcagcttt ataaaaagtt agttatagaa aagaagaggc tgctggaata agttttggga
    10561 ttgattggta tttcgctgaa tgatgcagat ataaagaata actcattata tttatggata
    10621 agattatagc tattattcct gcgcgatacc aatcatcacg ctttcctgga aagccattgg
    10681 ctgatatttt tggaagacca atgatttggt gggtttacaa tcaggtaatt aaagtaaaag
    10741 aattcttaga ggtttatgta gccacagacg atcaacgaat tgctgatgtg tgctcgaatt
    10801 atggtatgaa gtttatcatg acccagtcaa atcatccaac tcatgtgcat aggattcatg
    10861 aggtaagtga taatattgca gctgactatt atgttgtagt ttgcggtgat gaacctttga
    10921 ttagcccgga tataatagag gctgtttttc cttcgcaaga tgttgataat agccatatgt
    10981 atgttggtgg tctctgtcga tacttcacag aaccagcaga agttattgat cccgcaaata
    11041 ttaagattgt gactaatgat tcagatgaat gtgtattgtt atcaagagca cctattccgt
    11101 ttccttataa gactgtgctt tttaaatata aaaaagtggt gggtgtggaa tgctataata
    11161 aacaagcttt agattttttt gtctccacac ctaaaggcta tctggagaat atcgaggatg
    11221 taacacttca gcgatttttg gagaataaga ttcacatcaa atataaattg gtggattcag
    11281 tatctctttc tgttgatacc cctcgagact tggagaaggt aaaagaaata atggtgacaa
    11341 aacaagcttg aactatggaa aaaaaagtat taatgttaga ttgtacgcta cgtgatggtg
    11401 gctatgtcaa tgattgggat tttggtcata gtactattac gggtatttat aagcgattgg
    11461 aagcagcagg tgctgattat attgaagtgg gtttcttgga tgacagaaga gaatttgata
    11521 taaatcgttc catcatgcca agtacagaag ctatcaataa aatctttggt tctgtaaaaa
    11581 aaggaaaagc gatacctgta gcaatgattg actttggcac ttgttctctt gatagtatag
    11641 gttcttgtga ttctactttt attgatggta ttcgagttat cttcaagaaa gaaaaaatag
    11701 atcaagcttt gccattctgt aaagctatta aggaaaaagg ctataagctc ttcatacaag
    11761 ccatttcaat tacagcctat agtgacattg aaatgcttga gtatgtaaat cgcatcaatg
    11821 aaattaaacc ttatgctttt tctattgtag acacttatgg tttgcttgat aatagcagta
    11881 tggctcgata tttctacttg atagacaaca atttggaccc tagtattaaa atggggtatc
    11941 atgagcacaa taacttccaa ttgggcttta gcaatacaat taaatttttg gagaaaagta
    12001 ccaaaagaac actggtggca gattctacgg tttatggcat gggaaaaagt gccggaaatt
    12061 gtgccagcga acttttagcg atgcatttaa acgaatatta cggagggcat tacgatttaa
    12121 accagttgtt ggagattgtt gatacagatt tgatgccgat ttatcagaaa cattattggg
    12181 gctacaaata tgatttctac attgcttcga tgcaacgatg tcatccgtcc tatgtccagt
    12241 atcttctcaa aaagagtaca ttgtctgtca gctcaattaa tgaaattctt tcctcaatac
    12301 ctgaagaaat aaagttgctt tataacaaac aatggataga gcaagcatat ctcgattatc
    12361 agaatagagc gaaggacgat actgaggctt tacagcaatt gaaagttgaa cttgaagcag
    12421 cgagtgacaa acctgtattg ataattggtc cgggcaatac tgtcaaggag caaaaaaaag
    12481 gggtggagtt attcatttcg gggaatgatc cagttgtctt ttctgtaaat ttctatacaa
    12541 aactttattc tattgattat acttttataa gtaatgccaa gcgttacgct aagtttgtgg
    12601 atattcagca cggtgacagt attggctcta aactgattct tacatctaat gttaccgcat
    12661 gtgactatat gcctaattat gttctcaatt atgagtcact gttgaataaa gaatctgaaa
    12721 atcctgataa tgctcttgtt ttgctgctta aggctttaat aagaattgga atcacagaag
    12781 tatatcttgc aggttttgat ggatttacaa atacacctaa tgattattat gatcgcgatt
    12841 acgaactttc atcaactaaa gatgaaagtt ataatgatct tttgtcagat gatttatcta
    12901 aaataaatca gtcaatccgt cttcatttca ttacagaaag tttgtatgat gtcagataag
    12961 caaactatta aagcggtcct gtttgatttg gatgggactc ttttgaatac aagtgaagga
    13021 atagcatgta gtgtcttgca cacgctgtct gtaatgcaac tcccctctat atcctctgac
    13081 gaggtatcaa catttatagg cccccctatt caagaatctt taaaacgtca ttttagatta
    13141 tcagatgaag atgttcaaaa gggggcggat atatttcgtg cctattataa agactgtgct
    13201 ttgtttaaag cagctttata tccaggtatc attgacttgt tgaaacagtt gaagcaaaaa
    13261 gggtttctta ttggagtagc tacatataag cgtgaagatt atgctatgga tattctaaag
    13321 cattttggta ttttagaata ttgtgatgtc gttcatggtg cagacaatga taataaactc
    13381 cgtaagagtg atattgttta tctttgtata tctgaaatgt cagtggataa tagcgaagtg
    13441 gttttagtag gtgatacata tcatgatttg gaaggagcag aagaggctga tattcatttt
    13501 attgctgtaa cttacggttt tggttttaga gaaagtgtaa gagaactttc tagtaaaaac
    13561 gtggtgggag tagctgataa tccaatggaa atagaggggc tgctgaagtg aatttcataa
    13621 tag
//
