LOCUS gnlProkkaEBMCACGO_67 25222 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|EBMCACGO_67. ACCESSION gnlProkkaEBMCACGO_67 VERSION gnlProkkaEBMCACGO_67 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2025-04-28 17:00:30 Original ID :: gnl|Prokka|EBMCACGO_67 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 25222 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..25222 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="True" /core_location="[1394:5222]" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" /tool="antismash" proto_core 1395..5222 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" cand_cluster 1..25222 /SMILES="NC(CC(C)C)C(=O)O" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(Condensation and (AMP-binding or A-OX))" /kind="single" /product="NRPS" /protoclusters="1" /tool="antismash" region 1..25222 /candidate_cluster_numbers="1" /contig_edge="True" /product="NRPS" /region_number="1" /rules="cds(Condensation and (AMP-binding or A-OX))" /tool="antismash" CDS 3..1358 /NRPS_PKS="Domain: Epimerization (1-288). E-value: 1.2e-148. Score: 488.0. Matches aSDomain: nrpspksdomains_ctg22_1_Epimerization.1" /NRPS_PKS="Domain: TIGR01720 (292-441). E-value: 6e-55. Score: 177.2. Matches aSDomain: nrpspksdomains_ctg22_1_TIGR01720.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Condensation" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 129.7; E-value: 2.9e-39)" /gene_kind="biosynthetic-additional" /locus_tag="ctg22_1" /sec_met_domain="Condensation (E-value: 2.5e-78, bitscore: 258.1, seeds: 42, tool: rule-based-clusters)" /transl_table=11 /translation="MNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVYR EENGDIVQAYKPIGESKVSFEIVDLYGSDEEMLRSQIKILANKLQSSLDLRTGPLLKAE QYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDWAEE LAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTEEDTKHLLT DVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVGWFTAQ YPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEISFNYLGQ FDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGQFVLSCSYNEKEFERATVE EQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENLK" aSDomain 6..866 /aSDomain="Epimerization" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg22_1_Epimerization.1" /evalue="1.20E-148" /label="ctg22_1_Epimerization.1" /locus_tag="ctg22_1" /protein_end="288" /protein_start="1" /score="488.0" /tool="antismash" /translation="NFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVYRE ENGDIVQAYKPIGESKVSFEIVDLYGSDEEMLRSQIKILANKLQSSLDLRTGPLLKAEQ YRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDWAEEL AAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTEEDTKHLLTD VHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVGWFTAQY PVVLDI" aSModule 6..1325 /domains="nrpspksdomains_ctg22_1_Epimerization.1" /domains="nrpspksdomains_ctg22_1_TIGR01720.1" /incomplete /locus_tags="ctg22_1" /tool="antismash" /type="unknown" CDS_motif 63..137 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_1_0001" /evalue="1.50E-06" /label="C2_LCL_024-062" /locus_tag="ctg22_1" /protein_end="45" /protein_start="20" /score="20.6" /tool="antismash" /translation="FDPERVEKTLQALIEHHDALRMVYR" CDS_motif 342..407 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_1_0002" /evalue="2.80E-12" /label="NRPS-E2" /locus_tag="ctg22_1" /protein_end="135" /protein_start="113" /score="38.7" /tool="antismash" /translation="LLIAVHHLVVDGVSWRILLEDF" CDS_motif 810..860 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_1_0003" /evalue="1.10E-08" /label="NRPS-E5" /locus_tag="ctg22_1" /protein_end="286" /protein_start="269" /score="27.1" /tool="antismash" /translation="NISRTVGWFTAQYPVVL" aSDomain 879..1325 /aSDomain="TIGR01720" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg22_1_TIGR01720.1" /evalue="6.00E-55" /label="ctg22_1_TIGR01720.1" /locus_tag="ctg22_1" /protein_end="441" /protein_start="292" /score="177.2" /tool="antismash" /translation="ASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEISFNY LGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGQFVLSCSYNEKEFERA TVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGD" CDS_motif 900..959 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_1_0004" /evalue="6.50E-12" /label="NRPS-E6" /locus_tag="ctg22_1" /protein_end="319" /protein_start="299" /score="37.4" /tool="antismash" /translation="VKENLRRIPDKGVGYGILRY" CDS_motif 993..1022 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_1_0005" /evalue="1.10E-03" /label="NRPS-E7" /locus_tag="ctg22_1" /protein_end="340" /protein_start="330" /score="11.3" /tool="antismash" /translation="PEISFNYLGQ" aSDomain 1395..1490 /aSDomain="NRPS-COM_Nterm" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg22_2_NRPS-COM_Nterm.1" /evalue="1.40E-16" /label="ctg22_2_NRPS-COM_Nterm.1" /locus_tag="ctg22_2" /protein_end="32" /protein_start="0" /score="51.3" /tool="antismash" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQ" CDS 1395..5222 /NRPS_PKS="Domain: NRPS-COM_Nterm (0-32). E-value: 1.4e-16. Score: 51.3. Matches aSDomain: nrpspksdomains_ctg22_2_NRPS-COM_Nterm.1" /NRPS_PKS="Domain: Condensation_DCL (9-308). E-value: 3.7e-119. Score: 389.1. Matches aSDomain: nrpspksdomains_ctg22_2_Condensation_DCL.1" /NRPS_PKS="Domain: AMP-binding (469-867). E-value: 1.9e-112. Score: 367.7. Matches aSDomain: nrpspksdomains_ctg22_2_AMP-binding.1" /NRPS_PKS="Domain: PCP (973-1042). E-value: 1.5e-25. Score: 81.1. Matches aSDomain: nrpspksdomains_ctg22_2_PCP.1" /NRPS_PKS="Domain: Thioesterase (1059-1259). E-value: 5.4e-37. Score: 120.2. Matches aSDomain: nrpspksdomains_ctg22_2_Thioesterase.1" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 333.5; E-value: 3.9e-101)" /gene_kind="biosynthetic" /locus_tag="ctg22_2" /sec_met_domain="Condensation (E-value: 2.5e-93, bitscore: 307.3, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 2.4e-122, bitscore: 403.4, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 1.8e-17, bitscore: 58.6, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKG SLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFQIEEIDLTHLTGSEQT AKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLF KVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEDFEGQTTFAEQRKKQ KDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVV SGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKQLQEQSLQSEPHQYVPLYDIQ SQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMASPGDEML IKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFLLTGLNPPA QAHETKPLTDWFKEAVNVNPDAPALTYSGQTLSYRELDEEANRLARRLQKHGAGKGSVV ALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEMKEQAA ELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKGNMTTHANIQGL VKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTDLIL QENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKALRVMGPGKLINCY GPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCISGMG VSKGYVNRADLTKEKFIKNPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIRGHRI ELEEIEKQLQEYPGVKDAVVVADRPESGDASINAYLVNRTQLSAEDVKAHLKKQLPAYM VPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNEMEETIAQIWSEVLGRKQ IGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAPTIAGISAYVKNGGPDGLQ DVTIMNQDQERIIFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADLIQK LQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVESDV EALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFDMPE WLASWEEATTGAYRMKRGFGTHAEMLQGETLDRNAGILLEFLNTQTVTVS" aSDomain 1422..2318 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg22_2_Condensation_DCL.1" /domain_subtypes="Condensation_DCL" /evalue="3.70E-119" /label="ctg22_2_Condensation_DCL.1" /locus_tag="ctg22_2" /protein_end="308" /protein_start="9" /score="389.1" /tool="antismash" /translation="QDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKGSLNIKCLEE SMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFQIEEIDLTHLTGSEQTAKINEYKEQ DKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLFKVYNALREQ KPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEDFEGQTTFAEQRKKQKDGYEPKEL LFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVVSGRPAEIKG VEHMVGLFINVVPRRVKL" aSModule 1422..5171 /complete /domains="nrpspksdomains_ctg22_2_Condensation_DCL.1" /domains="nrpspksdomains_ctg22_2_AMP-binding.1" /domains="nrpspksdomains_ctg22_2_PCP.1" /domains="nrpspksdomains_ctg22_2_Thioesterase.1" /final_module /locus_tags="ctg22_2" /monomer_pairings="Leu -> Leu" /tool="antismash" /type="nrps" CDS_motif 1431..1472 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_2_0001" /evalue="3.00E-05" /label="C1_DCL_004-017" /locus_tag="ctg22_2" /protein_end="26" /protein_start="12" /score="15.8" /tool="antismash" /translation="YYLSPMQEGMLFHA" CDS_motif 1494..1610 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_2_0002" /evalue="2.50E-12" /label="C2_DCL_024-062" /locus_tag="ctg22_2" /protein_end="72" /protein_start="33" /score="39.1" /tool="antismash" /translation="FYLEQITMKVKGSLNIKCLEESMNVIMDRYDVFRTVFIH" CDS_motif 1827..1892 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_2_0003" /evalue="1.70E-11" /label="C3_DCL_135-156" /locus_tag="ctg22_2" /protein_end="166" /protein_start="144" /score="36.5" /tool="antismash" /translation="YHHIILDGWCFGIVVQDLFKVY" CDS_motif 1938..1976 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_2_0004" /evalue="5.50E-04" /label="C4_DCL_171-183" /locus_tag="ctg22_2" /protein_end="194" /protein_start="181" /score="12.4" /tool="antismash" /translation="PYKDYIKWLEKQD" CDS_motif 2214..2309 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_2_0005" /evalue="1.30E-18" /label="C5_DCL_263-294" /locus_tag="ctg22_2" /protein_end="305" /protein_start="273" /score="59.4" /tool="antismash" /translation="DLAFGTVVSGRPAEIKGVEHMVGLFINVVPRR" CDS_motif 2358..2471 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_2_0006" /evalue="1.00E-17" /label="C67_DCL_14fromHMM" /locus_tag="ctg22_2" /protein_end="359" /protein_start="321" /score="56.6" /tool="antismash" /translation="QEQSLQSEPHQYVPLYDIQSQADQPKLIDHIIVFENYP" aSDomain 2802..3995 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg22_2_AMP-binding.1" /evalue="1.90E-112" /label="ctg22_2_AMP-binding.1" /locus_tag="ctg22_2" /protein_end="867" /protein_start="469" /score="367.7" /specificity="substrate consensus: Leu" /tool="antismash" /translation="FKEAVNVNPDAPALTYSGQTLSYRELDEEANRLARRLQKHGAGKG SVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEMKE QAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKGNMTTHANI QGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTD LILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKALRVMGPGKLI NCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCIS GMGVSKGYVNRADLTKEKFIKNPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIR" CDS_motif 2988..3029 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_2_0007" /evalue="2.60E-05" /label="NRPS-A_a2" /locus_tag="ctg22_2" /protein_end="545" /protein_start="531" /score="17.4" /tool="antismash" /translation="LGVLKAGAAYLPVD" CDS_motif 3222..3281 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_2_0008" /evalue="1.40E-08" /label="NRPS-A_a3" /locus_tag="ctg22_2" /protein_end="629" /protein_start="609" /score="26.9" /tool="antismash" /translation="AYIMYTSGTTGKPKGNMTTH" CDS_motif 3789..3878 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_2_0009" /evalue="5.50E-13" /label="NRPS-A_a6" /locus_tag="ctg22_2" /protein_end="828" /protein_start="798" /score="41.1" /tool="antismash" /translation="PFGAIGELCISGMGVSKGYVNRADLTKEKF" CDS_motif 3960..4025 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_2_0010" /evalue="9.60E-12" /label="NRPS-A_a8" /locus_tag="ctg22_2" /protein_end="877" /protein_start="855" /score="36.8" /tool="antismash" /translation="YAGRIDDQVKIRGHRIELEEIE" aSDomain 4314..4520 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg22_2_PCP.1" /evalue="1.50E-25" /label="ctg22_2_PCP.1" /locus_tag="ctg22_2" /protein_end="1042" /protein_start="973" /score="81.1" /tool="antismash" /translation="EETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELG IDLPVKLLFEAPTIAGISAYVKNG" aSDomain 4572..5171 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg22_2_Thioesterase.1" /evalue="5.40E-37" /label="ctg22_2_Thioesterase.1" /locus_tag="ctg22_2" /protein_end="1259" /protein_start="1059" /score="120.2" /tool="antismash" /translation="IIFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADL IQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVE SDVEALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFD MPEWLASWEEATTGAYRMKRGFGTHAEMLQGETLDRN" CDS_motif 4719..4793 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_2_0011" /evalue="6.30E-10" /label="NRPS-te1" /locus_tag="ctg22_2" /protein_end="1133" /protein_start="1108" /score="31.5" /tool="antismash" /translation="QPEGPLTLFGYSAGCSLAFEAAKKL" CDS 5251..5979 /NRPS_PKS="Domain: Thioesterase (14-231). E-value: 2.8e-55. Score: 180.1. Matches aSDomain: nrpspksdomains_ctg22_3_Thioesterase.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (smcogs) SMCOG1004:thioesterase (Score: 213.1; E-value: 5.1e-65)" /gene_kind="biosynthetic-additional" /locus_tag="ctg22_3" /sec_met_domain="Abhydrolase_6 (E-value: 1.1e-14, bitscore: 50.5, seeds: 455, tool: rule-based-clusters)" /sec_met_domain="PF00561 (E-value: 4.4e-06, bitscore: 21.4, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLAA EPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGV FPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSD YRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQ TEEVAERIFAILNQHPIIQP" aSDomain 5293..5943 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg22_3_Thioesterase.1" /evalue="2.80E-55" /label="ctg22_3_Thioesterase.1" /locus_tag="ctg22_3" /protein_end="231" /protein_start="14" /score="180.1" /tool="antismash" /translation="QLICFPFAGGYSASFRPLHAFLQGECEMLAAEPPGHGTNQTSAIE DLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGVFPQAVIISAIQPPH IQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSDYRALEQFELYDLAQ IQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQTEEVAERIF" CDS_motif 5476..5547 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg22_3_0001" /evalue="1.90E-08" /label="NRPS-te1" /locus_tag="ctg22_3" /protein_end="99" /protein_start="75" /score="26.7" /tool="antismash" /translation="PDRPFVLFGHSMGGMITFRLAQKL" CDS 6080..7306 /gene_functions="transport (smcogs) SMCOG1137:Major facilitator superfamily MFS 1 (Score: 336.7; E-value: 2.6e-102)" /gene_kind="transport" /locus_tag="ctg22_4" /transl_table=11 /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADRS LISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFSAI YGVLGGIGYSCAVGVTTQYFISRWFDTHKGLALAILTNANSAGLLLLSPIWAAAPYHAG WQSTYTILGIVMAAVLLPLLVFGMKHPPHAQVESVKKFYDWRGFWNVMKQSRLIHILYF GVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLGSRSVM LSILFVIRLLSLICLLIPILGIHHSELWYFGFILLFGLSYTGVIPLTAASISESYQTGL IGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIELVPFLDKQ KAKETHQSI" CDS complement(7321..7878) /locus_tag="ctg22_5" /transl_table=11 /translation="MIQYANESINLPGEIAFKDVREIFFYQIAKISCFYFLLFCAIFAA VNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKSKR TYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIEIPKRFFHSKEEIN RFKEIILKNTGTKKLKFKKDQH" CDS complement(7932..8870) /gene_functions="transport (smcogs) SMCOG1166:transporter, EamA family (Score: 155.8; E-value: 2.6e-47)" /gene_kind="transport" /locus_tag="ctg22_6" /transl_table=11 /translation="MVKHQQAPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRFT IAFAAATVPILFGWVKLSIRVKDVIAILPLALLYPALFFSFQAFGLVYSSSSEAGIIQA AIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLILLSA LSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPFREPG FVLGIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGVVILKESLAWYH LAGAVCIMIGVVGSNINLEKKTKRPGMPAKK" CDS 8994..9401 /gene_functions="regulatory (smcogs) SMCOG1136:GntR family transcriptional regulator (Score: 64.2; E-value: 2.2e-19)" /gene_kind="regulatory" /locus_tag="ctg22_7" /transl_table=11 /translation="MEKYMSLVTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVIR ALQELEKRHLIYSVPKSGYYIVKKTGKAKSGQPGPIDFATSAPDPNVFPYLDFQHCINK AIDTYLWDAKGASITHPCSPKALGHSTGICG" CDS 9373..10311 /NRPS_PKS="Domain: Aminotran_1_2 (8-306). E-value: 4.9e-19. Score: 60.5. Matches aSDomain: nrpspksdomains_ctg22_8_Aminotran_1_2.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1019:aminotransferase (Score: 206.7; E-value: 9e-63)" /gene_kind="biosynthetic-additional" /locus_tag="ctg22_8" /sec_met_domain="Aminotran_1_2 (E-value: 4.3e-18, bitscore: 60.5, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MATQQVFADERHIFITSGVQQALSLLCAMPFPNGKEKIAIEQPGY HLMVEQLETLGIPAIGVKRTEEGLDIAGVERLFQTESIKFFYTMPRFHNPLGCSLSERD KQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSSHVIYLKSFSKMIFPGLRVG AAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGMYGRHKEKIRDSYKERSLRLH QAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASRVIHRLKKQGVLLEAIDRHYLS DYPKENLLKINISNVKTEDIERGVKLLMSHL" aSDomain 9397..10290 /aSDomain="Aminotran_1_2" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg22_8_Aminotran_1_2.1" /evalue="4.90E-19" /label="ctg22_8_Aminotran_1_2.1" /locus_tag="ctg22_8" /protein_end="306" /protein_start="8" /score="60.5" /tool="antismash" /translation="DERHIFITSGVQQALSLLCAMPFPNGKEKIAIEQPGYHLMVEQLE TLGIPAIGVKRTEEGLDIAGVERLFQTESIKFFYTMPRFHNPLGCSLSERDKQELVRLA EAYDVYLVEDDYLGDLEENKKADPLYAYDLSSHVIYLKSFSKMIFPGLRVGAAVLPEAL TDTFYAYKKLNDIDCSMISQAALEIYLKSGMYGRHKEKIRDSYKERSLRLHQAIRTHRQ LGSGRFTFSSGQAPCMHTHLVLPQDLPASRVIHRLKKQGVLLEAIDRHYLSDYPKENLL KINISNVKTEDIERGVK" CDS complement(10306..10980) /NRPS_PKS="Domain: ACPS (103-166). E-value: 6e-20. Score: 63.4. Matches aSDomain: nrpspksdomains_ctg22_9_ACPS.1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1012:4'-phosphopantetheinyl transferase (Score: 188.7; E-value: 1.5e-57)" /gene_kind="biosynthetic-additional" /locus_tag="ctg22_9" /transl_table=11 /translation="MKIYGIYMDRPLSQEENERFMTFISPEKREKCRRFYHKEDAHRTL LGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVIGAFDSQPI GIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQEGKGLSL PLDSFSVRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAAHPDFPEDITMVSYEE LL" aSDomain complement(10483..10671) /aSDomain="ACPS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg22_9_ACPS.1" /evalue="6.00E-20" /label="ctg22_9_ACPS.1" /locus_tag="ctg22_9" /protein_end="166" /protein_start="103" /score="63.4" /tool="antismash" /translation="IGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWS MKESFIKQEGKGLSLPLD" CDS complement(11085..11732) /locus_tag="ctg22_10" /transl_table=11 /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSLF QHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPAPSTYT GSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMEITILFA AWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH" CDS complement(12053..12796) /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 221.9; E-value: 1.6e-67)" /gene_kind="transport" /locus_tag="ctg22_11" /transl_table=11 /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLLR CLNALEIPNRGELAFDNFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENVME GPIQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPELML FDEPTSALDPELVGEVLKVIKNLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVIVEQG PPEQIFSAPKEERTQRFLNRILNPL" CDS complement(12810..13514) /gene_functions="transport (smcogs) SMCOG1096:polar amino acid ABC transporter, inner membrane (Score: 244.4; E-value: 1.7e-74)" /gene_kind="transport" /locus_tag="ctg22_12" /transl_table=11 /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFIF GMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFPSA VIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIPPLS NTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQH VIERRLDRYVAK" CDS complement(13501..14307) /gene_functions="biosynthetic-additional (smcogs) SMCOG1091:glutamine-binding lipoprotein glnH (Score: 234.5; E-value: 1.7e-71)" /gene_kind="biosynthetic-additional" /locus_tag="ctg22_13" /transl_table=11 /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKG VLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLNSK RFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLTSNY NKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAFETGD PQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK" CDS complement(14423..15295) /gene_functions="regulatory (smcogs) SMCOG1014:LysR family transcriptional regulator (Score: 246.3; E-value: 6.3e-75)" /gene_kind="regulatory" /locus_tag="ctg22_14" /transl_table=11 /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELGV VLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYCAA LMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQLDDI PCVLVLSDEAGYPCGDTIKMEDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPRIVCE CHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTDSYLPK PAQQFLDLF" CDS 15385..15999 /gene_functions="biosynthetic-additional (rule-based-clusters) Flavoprotein" /gene_kind="biosynthetic-additional" /locus_tag="ctg22_15" /sec_met_domain="Flavoprotein (E-value: 3.7e-32, bitscore: 105.9, seeds: 143, tool: rule-based-clusters)" /transl_table=11 /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHLV VSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSLAS IRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMPAFY NQPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA" CDS 16002..17423 /locus_tag="ctg22_16" /transl_table=11 /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGAAARAASNLGDK SPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMPVK REETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQNVGI YRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPLLYDQ SEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTGHYSGG RSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPNEIVAVN AMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFNLPQVMWA LSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHYSQPLDSPL TTKEWEQKLMDLMNK" CDS 17440..17667 /locus_tag="ctg22_17" /transl_table=11 /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESIT NPEKYNPAFKIDPKETETAIEVPAVPERKA" CDS 17664..18128 /locus_tag="ctg22_18" /transl_table=11 /translation="MIGVNSMSDRLFELLDGRCLNEKQHEAFVLQTVSEDGWPHAAMIS AGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKDAE YDRDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLGRWEKTLEDLKR" CDS 18194..19039 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1036:alpha/beta hydrolase fold protein (Score: 65.6; E-value: 9.7e-20)" /gene_kind="biosynthetic-additional" /locus_tag="ctg22_19" /sec_met_domain="PF00561 (E-value: 1.6e-15, bitscore: 52.3, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 6.7e-09, bitscore: 31.6, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQK YQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMALEY ARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIANLPQDIDKDP ERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFAQIDLIQRLADVRM PVYIGLGRYDYMVAPVALWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFSKWLDQ " CDS complement(19080..20558) /gene_functions="transport (smcogs) SMCOG1202:major facilitator transporter (Score: 52; E-value: 7e-16)" /gene_kind="transport" /locus_tag="ctg22_20" /transl_table=11 /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRAI LLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGGIF IMFGHIALAYPGSAIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSIFYM GINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNVPNPL SKKSAIGTGIGVIIVAIAVIISVQTGVLTINRFIDLVSILGILIPVIYFIIMFTSKKAD STEKSRLAAYIPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWFQSLNPL FVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEALVSPLWLV LSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQVAGLFDKIP ETMYFGTIGLISIVLGGILLLLSPMIKRAMKGVL" CDS 20838..22592 /locus_tag="ctg22_21" /transl_table=11 /translation="MAEFILNAADFGVPGDGKTDSTERINQCLSTAVSKGYHTVWFPKG TYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQENIT ISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVSPRG LKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPKFGID IEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYGYGTQT VIKGNILRRPEDVAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRGKSVLVT NNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLNNCLIQVV DGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYSVSVTNNAG AIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIFDNTISVNRT AGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIFKGTINKHSSD TIDGNMIV" CDS complement(22607..22828) /locus_tag="ctg22_22" /transl_table=11 /translation="MKILGVTGVILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTTF AEWVVLLFFVLVLVREMYVIYKSKKKNP" CDS 22954..24588 /locus_tag="ctg22_23" /transl_table=11 /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNIA ETKKEVGSSSDVIIREIKIGEQDHVHLAVIYIAGLVDNNTIHESLIDPLVQDESIQNTH AIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSIQEP STQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQGICDE KVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLEGRFAI IVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVYVAATTF HQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSAVSIVGAL VIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASAVMGFYGLI LGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPESVSKEDKVRQ GKDQRPEPAASRGMVNKDLEEGDQNGT" ORIGIN 1 aaaagaactt cacgaacaag caccactgga accaatctgt gatgcttcac gccaagaagg 61 gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct gatcgagcat catgacgcgc 121 tccgcatggt ctatcgtgag gaaaacgggg acatcgttca ggcgtataaa ccgatcggtg 181 agagcaaggt cagcttcgaa atcgtggatc tgtacggctc tgatgaagag atgctgagaa 241 gccagattaa gattctcgcg aacaagctgc aaagcagtct cgatctgaga accgggccgc 301 ttttaaaggc ggagcaatat cgcacagaag ctggggatca cctgctcatt gctgtacacc 361 atctcgtggt cgacggtgtg tcatggcgga ttttgcttga agactttgct tcaggctaca 421 tgcaggctga gaaagaagag agccttgtct tcccgcaaaa aacaaactcc ttcaaggact 481 gggcggaaga actggcggca ttcagccaat cagcgcatct tttacagcag gctgaatact 541 ggtcgcaaat tgccgctgaa caggtttctc ctttaccgaa ggattgtgaa acagagcagc 601 ggatcgtcaa ggatacatca tccgtcctat gtgaattaac ggaagaagac actaagcatc 661 ttttaacaga tgttcatcag ccatatggaa ctgaaatcaa cgatattctt ctcagtgcgc 721 tcggtttgac aatgaaagaa tggacaaagg gtgccaaaat tggcattaac cttgagggac 781 acggccggga ggacatcatc ccgaatgtga atatctccag aacggtcggc tggtttacgg 841 cacaataccc tgttgtgctc gacatatctg acgcagatgc ctcggctgtg atcaaaacag 901 tcaaagaaaa cctgcgccgc attcccgaca aaggtgttgg ctacggcatt cttcgttatt 961 tcacagaaac agcggaaaca aagggcttca caccggagat cagcttcaac tatttgggcc 1021 aattcgacag tgaagtcaaa accgatttct ttgaaccatc cgctttcgat atggggcgcc 1081 aagtaagcgg agaatcagag gcgctgtacg ctttaagctt cagcggcatg atcagaaacg 1141 gccagtttgt gctttcctgc tcctacaatg agaaggagtt tgaaagagct acagtcgagg 1201 agcaaatgga acggtttaaa gaaaacctcc tgatgctaat ccgccattgc acggaaaaag 1261 aagacaagga attcacacca agcgacttca gcgccgaaga ccttgaaatg gacgagatgg 1321 gagatatctt tgacatgctt gaggagaatt taaaataaaa cgcaagggaa ttacagaagg 1381 cgggagcgaa acatatgagt caatttagca aggatcaggt tcaagatatg tattacctat 1441 cgccgatgca ggaagggatg ctttttcatg ccatcctgaa tcccggccaa agcttttacc 1501 ttgaacaaat cacgatgaaa gtaaaaggca gcttgaatat caaatgtctt gaagaaagca 1561 tgaatgtgat catggaccgg tacgatgtat ttcgtaccgt gttcattcac gaaaaagtaa 1621 aaaggcctgt ccaagtcgta ttgaaaaaac ggcagttcca aatagaagaa atcgatctga 1681 cacacttaac gggcagcgag caaacagcca aaatcaatga gtacaaagaa caggataaga 1741 tcaggggttt tgatttgacg cgggatattc cgatgcgggc agccattttc aagaaagctg 1801 aagaaagctt tgaatgggtg tggagctacc accacattat tttggacgga tggtgcttcg 1861 gcatcgtcgt acaggatcta tttaaggtat acaatgctct gcgcgaacaa aagccgtaca 1921 gcctgccgcc cgtcaaaccg tataaagact acatcaagtg gcttgaaaag caggataaac 1981 aagcatcact gcgttactgg cgagagtatt tagaggactt tgaaggacaa acgacgtttg 2041 cggagcaaag aaagaaacaa aaggacggct atgagccgaa agagctgctc ttttcactgt 2101 cggaggcgga aacaaaggct tttactgagc ttgcaaaatc gcagcatacc actttaagta 2161 cggcgctgca ggcagtctgg agcgtattga tcagccgcta tcagcagtct ggcgatttgg 2221 ctttcggtac agttgtttca gggcgtcccg cggaaatcaa aggcgttgaa catatggtcg 2281 ggctgtttat caacgttgtc ccgagacgtg tgaagctgtc tgagggtatc acatttaacg 2341 gcttgctcaa gcagctgcag gagcaatcgc tgcagtctga gccgcaccaa tatgtgccgc 2401 tttatgacat ccaaagccag gccgatcagc cgaaactgat tgaccacatc attgtttttg 2461 agaactatcc gcttcaggat gcgaaaaatg aagaaagcag tgaaaacggc tttgatatgg 2521 tggatgttca tgtttttgag aagtcgaatt atgatctcaa cctgatggct tccccgggag 2581 atgagatgct gattaagctt gcctataatg agaatgtgtt tgatgaggcg tttatcctgc 2641 gcttgaaatc tcagcttctc acagcaattc agcagctcat ccagaatccg gatcagcctg 2701 tcagcacgat caacctcgtt gacgacaggg agagagaatt tttgctaacc ggcttaaacc 2761 cgcctgctca agctcatgaa acaaagcctc tgacggattg gttcaaggaa gcagtgaacg 2821 tcaatccgga tgcgcctgcg cttacgtatt ccggccagac cctgtcttat cgcgaattag 2881 atgaggaagc gaaccgcctt gcacgccggc tgcaaaaaca cggtgcgggc aaaggctctg 2941 ttgtagcgct gtacacgaag cgctcacttg aattggtgat cggcattctc ggtgtattaa 3001 aggcgggagc agcctatctg ccagttgatc cgaagctgcc agaggaccga atctcgtata 3061 tgctggctga cagtgcggca gcctgtcttc tgacgcatca ggagatgaaa gaacaagcgg 3121 ctgagctgcc gtatacaggc acaacgctct tcattgatga tcaaacacgg tttgaagaac 3181 aggcaagcga tcctgcaacc gcgattgatc ctaatgatcc ggcatatatc atgtacacgt 3241 ccggcacaac cggaaagcca aaaggcaata tgaccactca tgccaatatt caaggtttgg 3301 tcaagcatgt agactacatg gcattttctg atcaggatac gttcttgtct gtttcgaatt 3361 acgcctttga cgcatttacc tttgatttct atgcttctat gctgaatgcg gcacggctca 3421 ttatcgcaga cgaacatacg ctgcttgata cagaacggct cacagatctg attctgcaag 3481 agaatgtcaa tgtcatgttt gcgacaaccg cactatttaa tcttctcacg gatgcgggag 3541 aggattggat gaaggggctt cgctgtatat tattcggcgg agagcgcgcc tcagtgcctc 3601 atgtcagaaa agcgctgcgg gtcatggggc cgggcaagct gattaactgc tacgggccga 3661 ctgagggaac agtgtttgcg acagctcacg tcgtgcatga tctgccggat tccatctcct 3721 cattgccgat tggaaagccg atcagcaatg ccagtgttta tattctgaac gagcaaagcc 3781 agctccagcc attcggggcg atcggtgaac tgtgcatcag cggaatgggc gtgtcaaaag 3841 gatatgtaaa tcgtgctgac ctcacgaagg aaaagtttat taagaacccg ttcaagccgg 3901 gagaaacgct ttaccgcaca ggggatttag cgcgctggct gccggatgga acgattgaat 3961 acgccggccg tattgacgac caggtcaaaa tacgcggaca ccggattgag cttgaagaaa 4021 tcgaaaagca gctgcaggaa tacccaggtg tgaaagatgc ggtcgttgtg gcggaccgcc 4081 ctgagtctgg cgatgcatca atcaatgcct accttgtgaa ccggacgcag ctttcagctg 4141 aggacgtgaa ggcgcacctg aaaaaacagc ttcctgctta tatggtgccg caaaccttta 4201 ccttcttgga tgagcttcct ttaacgacga acgggaaagt caataaacgg ctgctcccaa 4261 aacctgatca ggatcagctg gcggaagaat ggattggacc gcggaacgag atggaagaaa 4321 caatcgcaca aatctggtct gaggttctcg gcagaaagca aattggcatt catgacgatt 4381 tctttgcgct cggagggcat tccttaaagg ccatgaccgc cgcttcccgc atcaagaaag 4441 agcttgggat tgatcttcct gtaaagcttt tatttgaagc gccgacgatc gccggcattt 4501 cagcgtatgt gaaaaacggg ggccctgatg gcttgcagga tgtaacgata atgaatcagg 4561 atcaggagcg gatcattttc gcattcccgc cggttctggg ctatggcctt atgtaccaaa 4621 atctgtccag ccgcttgccg tcatacaagc tgtgcgcctt tgattttatt gaggaggaag 4681 accggcttga ccgctatgcg gatttgatcc agaagctgca gccggaaggg cctttaacat 4741 tgtttggata ttcagcggga tgcagcctgg cgtttgaagc tgcgaaaaag cttgaggaac 4801 aaggccgtat tgttcagcgg atcatcatgg tcgattccta taaaaaacaa ggtgtcagtg 4861 atctggacgg acgcacggtt gaaagtgatg tcgaagcgtt gatgaatgtc aatcgggaca 4921 atgaagcgct caacagcgaa gccgtcaaac aaggcctcaa gcaaaaaaca catgcctttt 4981 actcatacta cgtcaacctg atcagcacag gccaggtgaa agcagatatt gatctgttga 5041 cttccggcgc tgattttgac atgccggaat ggcttgcatc atgggaagaa gctacaacag 5101 gtgcttaccg tatgaaaaga ggcttcggaa cacacgcaga aatgctgcag ggcgaaacgc 5161 tagataggaa tgccgggatt ttgctcgaat ttcttaatac acaaaccgta acggtttcat 5221 aaatgaagtg atgaaaggag gagacagcca atgagccaac tcttcaaatc atttgatgcg 5281 tcggaaaaaa cgcagctcat ctgttttccg tttgccggcg gctactcggc gtcgtttcgc 5341 cctctccatg cttttttgca gggggagtgc gagatgctcg ctgccgagcc gccgggacac 5401 ggcacgaatc aaacgtcagc tattgaggat ctcgaagagc tgacggattt gtacaagcaa 5461 gaactgaacc ttcgccctga tcggccgttt gtgctgttcg gacacagtat gggcggaatg 5521 atcaccttca ggctggcgca aaagcttgag cgtgaaggcg tctttccgca ggcggttatc 5581 atttctgcaa tccagccgcc tcatattcag cggaagaaag tgtcccacct gcctgatgat 5641 cagtttctcg atcatattat ccaattaggc ggaatgcccg cagagcttgt tgaaaataag 5701 gaggtcatgt cctttttcct gccttctttc cgatcagatt accgggctct tgaacaattt 5761 gagctttacg atctggccca gatccagtcg cctgttcatg tctttaacgg gcttgatgat 5821 aaaaaatgca tacgagatgc ggaaggctgg aagaagtggg caaaagacat cacattccat 5881 caatttgacg gcgggcacat gttcctgctg tcacaaacgg aagaagtcgc agaacggatt 5941 tttgcgatct tgaatcagca tccgatcatt caaccgtgat caaaagcgga cagcttcggc 6001 tgttccgctt tttttgtgtt gaatgccaat ttctgcatgg tataatagtc gaaatactca 6061 aataaaggca ggtcgaaaca tgcgcacgtc tcccaggatg aaatggtttg tattgctgtt 6121 tacgtttgtt ttcgccatcg gaatgaactc attcagaaat tcctttcaat tttttatgtt 6181 gccaatggcg gatgccttcc atgccgacag gtcgctgatt tcggtttctg tcagcatttt 6241 tatgatcaca accggcatcg tccagttttt tgtcggtttt tttatcgacc gtttcagtgt 6301 cagaaaaatt atggcacttg gagctgtctg catcagcgca agctttttgg tgcttcctta 6361 ttcaccgaat gttcatgtgt tttccgccat ttacggtgtg cttggcggaa tcggctattc 6421 ctgcgcggtc ggcgtgacga cccagtactt catcagccgt tggtttgaca cacacaaagg 6481 tctggcgctt gctattttga ccaatgccaa ctctgcgggc ctgctgcttc tctcgcccat 6541 ttgggctgcg gctccgtatc atgccggctg gcagagcacc tatacgattt tgggaatcgt 6601 catggcggct gttctgctgc cgctcctcgt ctttgggatg aagcacccgc cacatgcgca 6661 agtggagtct gtgaaaaaat tttatgattg gcgggggttt tggaacgtga tgaagcaatc 6721 ccgcctcatt catatcctgt acttcggcgt gtttacttgc ggatttacaa tgggaattat 6781 tgatgctcac ctcgtcccga tactgaagga tgcgcatgtc tctcatgtca acggaatgat 6841 ggccgcgttc ggggcgttta tcatcattgg cggattattg gcgggctggc tgtccgatct 6901 cctcgggagc agaagcgtca tgctatccat cttatttgtc attcggctgc tcagcctgat 6961 ttgcctgctc attcccattc tcggaattca tcacagcgaa ctttggtatt ttggctttat 7021 tctgttattc gggctcagtt acacaggcgt gatcccgctg accgcggcgt caatttcgga 7081 aagctatcaa acaggattga tcggatcgct gttaggcatc aatttcttta tccatcaggt 7141 tgccggagct ctcagcgtgt atgcgggcgg tttgtttttt gacatgactc atggttattt 7201 gctgattgtc gctgtgtgca tcgtgtttgt gggtttatcg gctgtaatag agctggtgcc 7261 gtttttagat aaacaaaagg caaaagaaac ccaccaatca atataaaagg atcagcactg 7321 tcaatgctga tcctttttaa atttgagttt ttttgttccg gtatttttaa ggataatctc 7381 cttgaatctg tttatttcct ctttggaatg aaaaaaacgt tttgggatct caatatattg 7441 gccacttgat gtattgaccc tgaagatatt tttatattcg aaaacagctg tgatttcatc 7501 ccaattgaaa atgaggtcat attttttaga acatatacga attccttctt gatttagagt 7561 atatgttctt ttagatttca tccgttcgtt cttcttgtat gctctggaaa acttcacata 7621 tagaagcagg aggagcagca gtgtaaacag aacggacatc acgataatca acatactgtt 7681 cataaataag ttaagcgcgt cactgccata aacgatacgg ggccatccgt taatgaagtt 7741 aactgcagca aatatggcgc aaaacaacag aaagtaaaag catgatattt ttgcgatttg 7801 ataaaaaaag atttctctta catccttaaa agcaatttct cctggaagat tgatactttc 7861 attagcatat tgaatcatac ggtaaaccta cacctctaac catgtttttc ctttcagtct 7921 agcataattt ctcatttttt tgcaggcata ccagggcgct ttgttttttt ctccagattg 7981 atattgctcc ccaccacgcc aatcataata caaacagccc cggcaagatg ataccaggcc 8041 aggctttctt tgagaatcac aactcctgca atcatcgtca caatggtaga tacatgatta 8101 aaagcgctca ttttaaacgc ctcaattcgc gacagcgtat agttagacag aaacgaagta 8161 acaagtgaag acagcacgcc caaatacaca atgccgagaa cgaagccggg ctcccggaac 8221 ggcagaaaat aagtgccgac tgttcccgcc gctccgtgac gcacaagggc gatggcgttg 8281 aagacgacaa agccgatggc tgacatgatg taggtgagct cggtcagctt gaaccgctgc 8341 gtcatttttc tggcagcagt attgtacatc gctgaagaca aagcggacaa taggatcagc 8401 aaagaccctt ttaagctggc tgattccacg tcaacgcctt tcatcacaaa aataaacatg 8461 acgccggcaa cggataaaac cgtgaacccc ttttgggtcc acgttgggcg ttcctttaaa 8521 acataagcgg caaagaccat cgtgaaaatc ggaatggctg cctgaataat tcccgcttca 8581 gaggaggacg agtacacaag gccgaatgcc tgaaagctga aaaataatgc gggatacagc 8641 agggcgagcg gcaaaatggc aatgacgtcc tttacgcgga ttgatagctt tacccagccg 8701 aataagatcg gtacagtggc cgcagcaaac gcaatggtga accgatgcgc caaaatatca 8761 aacggctctg ctgtttgcag tgcgattttt acgaatagaa aggataaacc gataatgaac 8821 gaatataaaa tagccgctat ataagcgggg gcttgctgat gtttaaccat aatgggaatg 8881 gctcctttac ctgaattgca gcgccggtcg ctccctttat tgtatggccg cggtcagaac 8941 ggtacaatga gaaaaacaat gaactgtacc ggtacaaaac agggggagaa ggcatggaga 9001 aatatatgag tctagtaacg aggatagagg agatgatgca aagcacctcc tatcaagaag 9061 gagacaggct tccatctatc cgtcagctgt ccgcccgcta ccaagtcagc aaaagcacag 9121 tgatccgcgc gctgcaggag ctggaaaaac gccaccttat ctattccgtt ccgaaaagcg 9181 gctactatat tgtgaaaaag acgggaaaag ccaaaagcgg gcagcctggc cccatcgatt 9241 ttgccacatc tgcgccggac ccaaatgtgt ttccgtatct tgattttcag cactgcatca 9301 acaaagcgat tgatacttat ttatgggacg ccaaaggggc ttccatcact catccgtgtt 9361 ctccgaaagc tcttggccac tcaacaggta tttgcggatg aacggcatat tttcattaca 9421 tcaggtgtcc agcaggcgtt atctctgctt tgtgccatgc catttccaaa tgggaaagaa 9481 aagatcgcca ttgaacagcc gggctaccat ttgatggtcg aacagcttga gacgcttggg 9541 attcccgcca tcggggtgaa acgaacggaa gaagggcttg atatagccgg ggttgagcgg 9601 ttatttcaaa cagaatcgat taaatttttt tatacgatgc cgcgcttcca taacccgctt 9661 gggtgctcat tgtcagagcg tgataaacag gagcttgtga gactggcaga agcgtatgat 9721 gtctacctcg ttgaggatga ttacctcggt gatctggagg aaaataaaaa ggcagatccg 9781 ctgtacgcat atgatctgtc ctcacatgtc atctatttga aaagcttctc gaaaatgata 9841 ttccccggcc ttcgcgtggg ggcggctgtt ttgcccgaag cgctgactga cacgttctat 9901 gcgtacaaaa aactgaacga catcgactgt tcgatgattt ctcaagcggc attggagatt 9961 tacctgaaaa gcggtatgta cggcaggcat aaggagaaaa tcagagattc ttataaagag 10021 cggtcgctga ggctacatca agccattcga actcacaggc agctgggaag cggacgcttt 10081 acgttctcca gcgggcaggc accctgtatg cacacccatc tggtgcttcc tcaggatctg 10141 cccgcctcaa gagtgattca tagactgaaa aaacaagggg ttctccttga ggcgatagac 10201 cgtcattatt tatcagatta tccgaaagaa aatctattaa aaatcaatat ttccaatgtg 10261 aaaacggaag atattgagcg cggtgtcaag ctgttgatga gccatttata aaagctcttc 10321 gtacgagacc attgtgatat cctcggggaa atcagggtgt gcggcgcata cagccatttt 10381 gtagccggga tcgacctcat acgttttgat atagcatggg gaatggctgt ccggaagctc 10441 aatggatact tgtccgtcct ggtgcaggcg cactgaaaaa gaatcaagcg gaagcgataa 10501 gcctttgcct tcctgtttga taaagctttc tttcattgac catagatgat aaaaatagtc 10561 tgtctgctcg tccttgtctt ttgctaaaag gtcgctgtac tctgtttttg aaaaaaagcg 10621 cttggcgatc tcaaggctga tcggtttcgt tttttcgata tctatgccga tcggctgtga 10681 atcaaacgca ccaatgaccc agcggccgga gtgagaaatg ttgaaatgag cgtcgggaag 10741 atcagggatg cacggcttcc cgtattcctg cgtgctaaag cggatatcgg atttgtccaa 10801 ctgatactgc ctgcttatga ctgagcgaac gagcacatct cccagcaggg tgcggtgagc 10861 atcttcttta tgataaaatc tccggcattt ctcccgtttt tcaggtgata tgaaagtcat 10921 gaaccgttca ttttcttcct gtgaaagcgg gcggtccata taaattccgt aaatcttcat 10981 tctagatcct ccgtctgcaa aagattgtca aaaccatcct atcatacttc cacaagactc 11041 atatagagga gaaaataaaa aaacaaagcc aaggcggctt tgttttagtg gacaggcgga 11101 gatgctttca cagcggcggt ccgccttgcc acagcataat tcagcaactg gattgactgg 11161 ggcaatgaaa agcgcaaaat aagtcctgtg aggatggcgg tcaaaatggt gccaaaaccg 11221 atcggcccgc ccatgcccca tgccgcaaac aaaatggtta tttccatgcc gttccgcacc 11281 cattgcacat tccagccggt tttttcggta atcagcatca tcagtgaatc acgcggcccc 11341 gcgccaagcc ctgctgatac ataaacaccg acgccgtaac cgatcagcac cacgcctaga 11401 gagaagacga tgatcgagcc tgtgtaggtc gagggggcag gcagaatgaa attgaaaaaa 11461 tctataaata caccaatgag caccatattc aggagggccc caattttcgg ccaagctctc 11521 gtaaacaatg acgtgaatcc gacgatgagc gctccaataa tgatggacca ctggccgacg 11581 gtaagcccga agtgctgaaa caggctgtaa tgaaatgcat cccacggact aatgccgagt 11641 gcttttcctt ctatcgtcag ggatacacca aaagccaaaa tgatcaaacc ggcaaaataa 11701 aatgtccagc gcagaacaag ttcttgcttc acgtgaggtc ccttctttcg taaaaatcag 11761 tcgattgtca ttgtagcaca tctgacagaa gggcggaata ggcgaaaggg gcttaacaaa 11821 aaaacagggc cgccgcaggc gccctgtttc agcgtgttgg caaacccttg cattcgttgt 11881 caggcctgtt cttcggtgct cacgaattta acattcgctg tgctccaatg ctcggccttc 11941 ctagacttca aaggttttca atcacgctga aaatcacaaa atcctaaaac gaaaatcgtt 12001 ttaggatttt gtcaataatc tgaaacaggg cgcaggcgcc ctgtttttct tattacagcg 12061 ggttcaaaat ccggttcaag aaccgctgtg tccgttcttc ttttggtgcg gagaaaattt 12121 gctccggcgg tccttgctcc acgataacgc cgccgtcgat gaagatgact tcatccgcaa 12181 cttcctgcgc gaacttgatt tcgtgggtca cgacgaccat ggtccagcct tcattggcca 12241 agtttttgat aaccttcagc acctctccga caagctcggg atcaagcgct gaggtcggtt 12301 cgtcaaacag catgagctca ggctgaatcg ccagtgcgcg ggcgatgccg acgcgctgct 12361 gctggccgcc ggaaagctgg aacggatata aatccatttt gtccttcaat ccgactttat 12421 caagaagctg aatcgcttct tttctgactt cctctttgtt ccgtttttgc acctgaatag 12481 ggccctccat cacgttttcg agggctgtgc ggtgcgggaa caggtgatac gcctgaaaca 12541 ccattccgga ttttcggcga agctttagga tatccgcctg tttcaccttt ttagagaaat 12601 cgatggagaa attatcaaat gcaagctctc cgcgattcgg gatctccaga gcgttcaggc 12661 agcgaagcag cgtcgttttc cctgaacctg aaggcccaag tatggcgatg acttttcctt 12721 tttcaatctt catatctatc ttttttaaaa tttcattttc accgaatgat ttgtttaatc 12781 ctttaacggt aagcatactc ggaacctcct tatttggcca cgtagcggtc aagacgccgt 12841 tcgatgacat gctggacgag tgagagcagg aagcagataa tccaataaat aaaggctgct 12901 tcaatataga tcactaaaat ttgatcaaga ttccgcgcgc cgatttcctg ggcttttctg 12961 aacagctcag cgaccagaat ttgagaggcg agggatgtat ctttaatcag gctgataaag 13021 gtattggata atggcgggat cgacacacga aacgcctgcg gcaaaatgac gcggaacagc 13081 gttttttgat gtgtcatgcc aattgtgtag ccggcttccc attgcccttt cggcacggat 13141 aaaatagatg cccgaatgat ttcagatgca taggcgccga cgtttaaaga aaaggcgata 13201 actgcgcttg gaaatggatc taatgtgacg ttaaaggccg ggaacagata gaaaatgatg 13261 aacaattgaa cgagaagagg agtgccgcgt attgcggata cgtatacgct gaacacccat 13321 ctcaaaggtc tcactttcga cattctggca agcgccgtaa tcagcgccag gatcattccg 13381 aatataaagg aaagaatcgt aaggggaatc gtatagtaga ttccccctga aagtatcggc 13441 cagaatgact gctgcaccag atcccacggg atcgccgtgc caagcgtcaa tgccggcaga 13501 ttatttagaa acatcttcgc cgaaccattt tttagatatt ttagaaagag tcccgtcctc 13561 tttcatttct tttaatgctt tgttgacttg atcaacaacc tcgccgcttc ctttacggaa 13621 cgtgaaatat gttgactgag gatcacctgt ttcaaacgcg attttcacgt ttttattgcc 13681 agatgttttt aagtagttca atacggcaag cttatcgttg tatgtcatat cgacgcggcc 13741 ttgctggatc atttgaaggg cctgcgccat accttcaacg ccttctactt tagcgccggc 13801 atttgtagct aatttgttgt agttgcttgt cagtgattga gctgacgttt ttccttttac 13861 atctgcttca gacttaatat cgttgttgtc ttttttcgtt acgacaacgg ctcttgatgt 13921 tgtgtattta tctgagaaat catatttgtc ttcacgatct gtttttccga cttggttggc 13981 aacaacgtca aaccgtttgg aattcaggcc ggcaaacata ctgtcccact gtgtttcctt 14041 aaagtcgact ttaagcccga ggcgttttgc gacttctgtg ataacttcga catcatagcc 14101 agtcaattta tcagtgtctt tgtcgtggta agtgaacggc tcatatgttc cttccgttcc 14161 gactgtgagc acaccttttt tcttaattga agcccaaaga tcgccatctt tggcattatc 14221 ttttgactga ttgtcatttc ctgctccgca agctgcaaga gctgcaatac ttacgaccat 14281 gaataaagcc aataatgctt ttttcatctt attccccact tttctggttg attttattga 14341 aataaaaaaa tagcttacaa atctaaagga taactttttt ttagtatgag tcaagtaatt 14401 ggttttcata aggcaaaatc ttttaaaata aatccaaaaa ttgctgtgcc ggtttaggca 14461 aataactgtc cgttctccac atgacagccg gtgtcataat gaagggatta ttttcgatat 14521 ggacggtgtg aacgtgattt ctcatatgaa cgggaatcat tgtgacgggc aaaatagacg 14581 cgccgaatcc ggatgacacg aggctgagca aagttgcaga gtcgtggcat tcacaaacaa 14641 tgcgcggctc caggttcaaa cgatgaaatt cattcatgac ctgattatag acgccttttc 14701 cgttgacagg ccgcagcagg atcagcggaa atgaaggaat gtcctccatc ttaatggtgt 14761 ctccgcacgg atatccggct tcgtctgaaa gcacgagcac acatggaatg tcatcaagct 14821 gcttgaattg tactgtgtca cttttgatca gtgttgtcgt gaccgcggca tcgatttgac 14881 ggctttccag cagctctaac agcgtcgcgg gctcattttc ccaaatgtta aaggtgaggt 14941 gcgggtatct ctctttgatt tgtgttactt tttcgagcat caaagcggcg caataaatcg 15001 ttgaacctac ggccagcgtg ccggctacct cctccttcag ctcttgtacc tcaatgacgg 15061 catcctcaaa cctgtgcaga atctcttttg ctctttttag aaaaacagct ccttcatatg 15121 taagagtcat ttgttttttc ttgttccggt caaacaggac aacaccaagt tcgtcctcca 15181 gctgtttgag ctgcctgctt aaaggcggct gcgccatgtg aagctttttg gctgcggacg 15241 tgattttctg ttcttgggca atggtaatga agtatcgaag ctggcgaata tccaaaagaa 15301 agcgcctcct tatcatacct tttaggtatt aaatatagat ttaatagata tttttcatat 15361 ggatatatca ggagtatgat tgaaatgaaa gcagaattca agcgtaaagg agggggcaaa 15421 gtgaaactcg ttgtcggaat gacaggggca acaggggcca ttttcggggt caggctgctg 15481 cagtggctga aggccgccgg agtggaaacc catctcgttg tgtctccttg ggcaaacgtc 15541 acgatcaaac acgaaacagg ctatacctta caagaagtag aacaactggc cacatacacc 15601 tactcacata aggatcaggc ggcagccatt tcaagcgggt cgtttgatac cgatggaatg 15661 attgttgcgc cgtgcagcat gaaatctctc gcaagcattc gcaccggaat ggcggataat 15721 ctgctgacac gtgcggcgga tgtcatgctc aaggagagaa aaaaactcgt cctcttaacg 15781 agagagacgc ctttgaacca aattcatctc gaaaatatgc tagcgcttac gaaaatgggc 15841 accatcattc ttcctccgat gccggcattt tataatcagc cgagaagctt agaggaaatg 15901 gttgaccata ttgtattcag aacgttggac caattcggca ttcggcttcc tgaagcgaag 15961 cgctggaatg ggattgaaaa acaaaaagga ggagcttgat catggcttat caagatttca 16021 gagaatttct cgctgccctt gaaaaagaag gacagctgct tacagtgaat gaagaggtaa 16081 agccggaacc ggatttaggg gccgccgcac gggcagccag caatcttggc gataaaagcc 16141 ctgcgctctt atttaacaac atttacggct atcataacgc gcgaattgcg atgaatgtca 16201 tcggctcttg gccaaaccat gccatgatgc tgggcatgcc gaaagacaca ccggtaaaag 16261 aacagttttt tgaattcgca aagcgttatg accagtttcc gatgccggtc aaacgtgagg 16321 aaacagcgcc atttcatgaa aatgaaatca cagaagatat caatttgttc gatatactgc 16381 ctcttttcag aattaaccag ggtgatggag gctactattt agacaaagca tgtgtcattt 16441 cccgtgatct tgaggaccct gacaacttcg gcaaacaaaa tgtcggcatt tacagaatgc 16501 aagtcaaagg aaaagaccgc cttggcattc agcctgtccc gcagcacgat attgcaatcc 16561 atctgcgcca agctgaagaa cgcggcatca accttccggt cactattgcg ctcggctgtg 16621 agccggtcat tacaacggcg gcatcgactc cgcttctcta tgatcaatca gaatacgaaa 16681 tggcaggtgc gattcaaggc gaaccatatc gcatcgtcaa atcaaagctg tctgatcttg 16741 atgttccgtg gggcgctgaa gtggtgcttg aaggtgagat tattgccgga gagcgcgaat 16801 atgaagggcc gttcggtgaa ttcacaggcc attattccgg cggacgcagc atgccgatta 16861 tcaaaattaa acgcgtctat cacagaaaca atccgatctt tgaacattta tacttaggca 16921 tgccttggac agaatgcgat tacatgatcg gcattaacac atgcgtgccg ctttatcagc 16981 agttaaaaga agcgtatccg aacgaaattg tggcagtgaa cgccatgtac acacacggtt 17041 taatcgcgat tgtttccaca aaaacccgct atggcggatt tgcgaaagcg gtcggcatgc 17101 gcgcactcac aacgccgcac ggactcggct actgcaaaat ggtcattgtc gttgatgagg 17161 atgtcgatcc attcaacctt ccgcaggtca tgtgggcgct ttcgaccaaa atgcatccga 17221 aacacgatgc ggtcatcatt ccggacttat ctgtcctgcc gcttgatccg ggatccaatc 17281 catcaggaat cactcacaaa atgattcttg acgccactac accggttgcg ccggaaacaa 17341 gaggccatta ttcacagccg cttgattctc cgctaacaac gaaagaatgg gaacaaaaac 17401 taatggactt aatgaataaa taaggaaagg atgttcgaaa tgcatacatg tcctcgatgc 17461 gactcaaaaa agggagaagt catgagcaaa tcgcctgtag aaggcgcatg ggaagtttat 17521 cagtgccaaa catgcttttt tacatggaga tcctgtgaac cggaaagcat tacaaatccc 17581 gaaaaataca atccagcgtt taaaattgat ccaaaggaaa cagaaacagc aattgaagtt 17641 ccggcggtgc cggaacgaaa ggcttgatcg gcgtgaacag tatgtcagac cgtctctttg 17701 agctgcttga cgggagatgc ctgaatgaga agcagcatga ggccttcgtt ctgcaaacag 17761 tatcagagga tggctggccg catgccgcta tgatcagtgc gggtgaaatt atcgcgctga 17821 gccgaactga tatccgaatc gctctgtgga aaaacacaat gacttcggcc aacatccttc 17881 gcacaggaaa agcacagttc acggcgtggt ggaagggagc ggcctattat gtaaagcttg 17941 aatgcgcgcc tttaccgcct ttgaaagatg ccgaatatga tagagaccgt ttttcctgcc 18001 gcatcgtttc agtgaaggag gacgttgcga aatacgctga tttgacttca ggtgtccgta 18061 tacagcttca cagccctgaa gaggtgctgg gcagatggga aaagaccctg gaagatttaa 18121 agcggtaata tcgatagcct gacgccatgc gtcaggcttt ttttatataa tgaaaacaaa 18181 gggggcgtga gaaatggaac gtgcggggat ctgtcactcg gacggctttg atttagctta 18241 tcgaattgag ggcgagggcg cacccatcct tgtgatcggg agtgcggttt actatccgcg 18301 ccttttttcc tcagatatca aacagaaata tcaatgggtc tttgtcgacc ataggggatt 18361 tgctaagcct aagcgggagc ttcgtgcgga ggattcgagg cttgatgccg tcttggctga 18421 tatcgaaagg atgagaacat ttcttcagct tgaggatgtt actatcctgg gacattccgg 18481 gcacgctttt atggctttag agtatgccag gacatatccc aaacaagttc ggaaggtggc 18541 gctcttcaat actgcgcctg ataacagtga agaaagacag cgaaaaagcg aatcattttt 18601 catggaaaca gccagccttg agagaaagaa acgatttgaa aaagacatcg cgaatttgcc 18661 gcaggacatc gacaaagatc ctgaaaggcg ctttgtgcac atgtgtattc gcgctgaagc 18721 gaaaagcttt tatcaagagc ggccgcatgc agctgcctta tgggacggtg tattcacgaa 18781 tatgccgatc attgatgaat tatggggcaa tacatttgcc caaattgatc ttattcagcg 18841 gttagctgat gttcgtatgc cggtgtatat cggattaggg agatatgatt atatggttgc 18901 gcctgttgcg ctatgggatg ctgttgacgg tttatatccc catgtggata aggttatttt 18961 tgaaaagagc ggccatcagc cgatgctgga agaaccggaa gcctttgatc aaagcttcag 19021 caaatggctg gatcaataaa aaaacagccc gcagattaaa atccgcgggc tgtttctaat 19081 tataagaccc ctttcatcgc gcgtttgatc atcggcgaga gcagcaggag aatgccgcca 19141 agaacgatag aaatcaaacc gatggtgccg aagtacattg tttcaggaat tttatcaaac 19201 aatccggcta cttgggcatt gatcgcttgt gctgctgcgt tcgtcagaaa ccacatactc 19261 attgtctgtg cagagaaggc agctggggcc agtttcgttg tcacggataa accgactgga 19321 gacaggcaca gctctccaag cacgacaagc aggaagctga gaacgagcca aagcgggctt 19381 acgagtgctt cttttccttg catagcaggg aataccataa tgataaatga caatccggct 19441 aaaataattc cgattgagaa tttaactggt gtagacggct ggcgtttgcc aagcttcatc 19501 cagagccatg cgaatattgg cgcaaaaatg acgacaaaca atggatttaa tgattggaac 19561 catgatgatt gaagttcgaa tccgcccaat gaaagtctta tgcgttcatc agcgtatacc 19621 gcaagaatgg tcgctccctg ttcctgaatg gcccagaaca tgacagcacc gataaacaaa 19681 ggaatgtaag cggcaagacg ggatttttct gtgctgtccg cttttttgct tgtaaacatg 19741 atgatgaaat aaatgacagg aatcaaaata ccgagaatac ttacaaggtc gataaaacga 19801 ttgatcgtca gcacgcctgt ttgtacagag ataatcactg cgatcgccac gatgataaca 19861 ccgattccgg tgccaatcgc agatttttta gacagcggat tcggcacatt ggaacctgca 19921 agcccgaggt ttttctttct tgtcaaagca aaaacgataa gtccgagaag cattccgacc 19981 gcggcagctc cgaagccgag atgatagttg tacttctgtc cgagtgttcc gacaattaac 20041 ggtgcaagta aaccaccgag gttaatcccc atgtagaaaa tactgaaacc tgagtcgcgg 20101 cgcgggtctt ctttcgtgta aagatcccca accacgcttg aaacgtttgg ttttaataat 20161 cctgttccga caataataag caccatgctg atatagaatg cgatcgcgct gcccggatag 20221 gcgagtgcaa tgtggccgaa cataatgaat atgccgccgt aaaacacggt gtttgcggta 20281 ccgaataccc ggtcagcgag ccatccgcca ataatggtgg acatgtatac gagtgatccg 20341 taaatcgaca taatggcaac cgcagtgccc ttgtcaaagc cgagccctcc gtttaccgtc 20401 tctgtataca aatagtaaag taagattgct ctcattccat agtaagagaa acgctcccaa 20461 aattcggtga aaaatagtgt aaatagtcct cgcgggtgac caaagaaccc tttttgcggg 20521 acgcttttaa tgatactttc gttatcaatc gaagccatgt cagccaaacc ctttctaaaa 20581 aaagtgtatt ataaaaatca tattcttata taatacttgt gtcaatataa tttatactca 20641 tttcaaatag ttccataatg gaaaaattat aaatacctaa aaatagtgat ttcctcctaa 20701 tttttaaact ttttatcgtg agattttctt acacaactat tcctttatat ttttttaata 20761 aaattttaga gaaatgtaca agcagatcgg gcctttgtga gtaacatgat agtaatcata 20821 gagaaggagg ctcgcaattg gctgaattca tattaaatgc agcggatttc ggtgttcctg 20881 gagatggtaa aacggattcg acagaacgga ttaatcagtg cctcagtaca gctgtatcga 20941 aaggctatca tactgtctgg tttccaaagg gaacatattt aatagacgca acgcttggcg 21001 gagatcttaa tcagaggttt cgaaacgcgg ggatcattgt tcccggcaac cttgagatta 21061 tgatggaccc cgaatgtatc atgaaagtga tcccgaatag ttcgtggggt tattccgcat 21121 tttatgtggg caagcaagag aatataacca tttccggagg acaaattatc ggcgaacggg 21181 atgagcatac gtatgcctcg gcagggataa ggtcaaccca tgaatggggc tttggcatat 21241 gtattgaagg atgctcgaat gttgtcattg atgatgtgaa aatttctgat tttaccggcg 21301 atgggatcat agtcagccca aggggattaa agaccaatca agattatcga acgtcagagc 21361 aaattatcat ccgccgctgt gaggttcggc ggtcgaggag aaataacatt tccattaccg 21421 gatgtgacat ggtcacggtg gaggaatgct tgattgaaga tgccggaacg gggaatggaa 21481 cagcgccgaa attcggaatt gacattgaag gatatggcga aggtgacgtt gattatgagg 21541 aaccgattaa tgtatcaatt cgcaataacc actttgttgg aaacgtttca agttctgtga 21601 ccaattttaa cgggtatggc attttaatag aaggaaatca ctctgacaat acaatcagct 21661 acggatatgg gacgcaaaca gtgatcaagg gaaatattct gagacgccct gaagacgtgg 21721 cggctgcgcc aagagtcggg ataaccggac tcggtgtatc acaaggaaaa gagaccagtg 21781 atgcagtgat cgctggcaac ctcattaccg gattttcaac tggaattgat gtcaggggaa 21841 agagcgttct tgtgacgaac aacaaaatca gcaactttga aaacacaggg atattggttt 21901 accagtcttc cgacgtaaag gtagacggaa accaaattca aaacggactg tctgaaacaa 21961 ggcgcagcat cggtcttcgc gcagtgctgt cagatgacat cgcttttctg aataactgtc 22021 tcattcaagt cgttgacggt gtgaacgttt ccggcggaaa tatgatcatt aaagataatc 22081 tcctgagaaa attcagccgg ggcatttgga ttgctcaagg gaacgcggtg attgaaggga 22141 atacactgaa tcctgacgcg tttgaagcag tgccggaatc atattctgtt tccgtcacaa 22201 acaatgccgg cgccatcatc aaaaacaata catttaaaga gttcaaaaat taccccattt 22261 attgctccac aagtgcgaaa acctcaatta tcggcaacca cttagagaga tctccgcttt 22321 tggtcaccat ctatatcagc gccggtgtgc atgagatttt tgataatacc atttcagtca 22381 acagaacagc cgggaatccg attgtgattt atctcaatgg ctctgcaggc tctatcatct 22441 caggaaacac catcaataac ctctccgcgg gcactgcgac agctattcaa acaaacacgt 22501 caaccaattc caaaatcatc ggcaaccgca tttttaaagg gactatcaac aaacacagca 22561 gtgatacaat agacggcaat atgatcgtct gaaaaaagcg ccccctctag gggttctttt 22621 ttttcgattt atagatcacg tacatttctc tcacaagtac taacacaaaa aataaaagca 22681 cgacccattc cgcaaatgtt gtcatcttaa agctggacat attgttataa acggcttttg 22741 ttaaactgaa cccttgaagc atgtccatca atacagaaat agctaataaa caaattaata 22801 tgactccggt cacgcccaat atcttcatgc ttcatcatcc tccgctttta gtgtctatcg 22861 ttggcggaga agttataccg catctaaccc taatgcataa tctcaatttt aaaaggaaga 22921 atatgagaaa acgacaagga aaggtatttg tgtatgcctt tattttctaa gcgaaagaac 22981 aataccgatt caaaagacaa gcagaataca gacgaaagga atcaggaaca gcagcaagaa 23041 aaagaaaggc cggttctcat ttctccaagt ttggcaaaga atatagcgga aacgaaaaag 23101 gaagtcggaa gcagctctga cgtcatcatt cgcgagatta aaatcgggga gcaagatcat 23161 gtccacctag ctgttatcta tattgctggg ctggtcgata ataacacgat ccatgagtcg 23221 ttaattgacc cattggtaca ggatgagtct atccagaata ctcatgcgat ccagcaaatt 23281 cttgaaaaaa cgctcccgct gggcggggtg aaagcggaaa agagctggga caagcttttt 23341 tccgagttaa tgctcggcaa tgcgctcatt tttgctgatg gccatgatga agctttgatt 23401 tgcagcactc aagggggaga gcagcgctcc atccaagagc ctagcaccca ggtgtcattc 23461 cgcggcccgc gccaagggtt tacagagtct ctgcaaacca atatttccat gatccggcga 23521 tacattaaaa atccgaattt atgggttgaa aaaatgaaaa aaggttctgt tacgaatacg 23581 gatatcgctc tcatgtacat tcaaggaata tgtgatgaaa aggtgctgaa ggaagtgaag 23641 cagcgcctgg aaaaaataga tattgacagt attttggaat ctggatatat tgagcagctg 23701 attgaagatg aaacctttac gacgtttccg actatgtatc atacagaacg ccctgatgtt 23761 gtagcgggta atctgttaga aggaagattc gcgattattg tggacggaac accgtttgtg 23821 cttattgccc cggccttatt tgtccagttt tttcagtctg ttgaggatta ttattcgcgt 23881 tttgacattg cgacaagcat aagaattctt cgtgttttag tctttttcat ttcgcttgtg 23941 gcaccggctg tatacgtggc agccacgacg tttcatcaag aaatgatacc gactcagctg 24001 ttagtggtca ttgccgccca gcgggaaatt gtcccgtttc cggctgttgt ggaggcgctg 24061 acgatggagg ttgcttttga gattctgagg gaagcgggag tcaggctgcc ccgggttgtc 24121 ggctcggcag tgtcaatcgt aggcgcgctc gtaatcggcc aggctgccgt acaggctggt 24181 atcgtctctc cggcaatggt gattatcgtg gcactcaccg cgattgcgag cttcgcaaca 24241 ccggcgtttg caatggcgat ttcagcccgg cttattcggt ttatctttat tattgcctca 24301 gctgttatgg gtttttacgg gctgatttta gggatcatta tgatgtttgt ccacttatgc 24361 agtcttcgtt cattcggcgt tccatatatg tcgccgcttg cacctttttc ttcacaaggc 24421 gtaaaggacg cgcttttccg ggttccgtgg tgggccgatg aaaaaaggcc ggaatcggtc 24481 agcaaggaag ataaggtgcg gcaggggaaa gaccaacgcc cagagccggc cgcttcacga 24541 ggaatggtga acaaagattt ggaagaaggg gatcagaatg gtacgtaaat gtctattagc 24601 cgttctcatg cttttgagcg tcattgtgct gcccggctgc tgggataagc gggagctgac 24661 ggatcttgcg attatctcgg cgattggcat cgatcggaca aacgacagca actacgtgct 24721 gcatcttcaa attatcaatc caggaaatgt tgccggcggc cttcagggag gcggtgctgg 24781 agacaggccg cctgtatctg tctattcgat tgaaggtaac aatataacgg aagcactcag 24841 aaaagcctcc atgaaggtat cacggcggct ttattttgcc cataccaatc tagtcgtgat 24901 caatgaaaag ctggcaaaag aagaaggttt ggattttgta ttagataatc ttgaccggga 24961 cacagaattc aggacaacag caacattcgt cgttgcccat aaaacaaaag cagaaaatat 25021 tgtgaaaatc ttgacgccga ttgataaaat tccgtcaaat aaagtcaata aaacactcga 25081 tttcacggag gcacaatacg ggcgggtggt caaaatcaat attcaggacg ttttgaaaac 25141 acttgccgcc aacactatgg caccggtcat ccccggatat atgatgattg gtgacgataa 25201 aaaaggagtc agcatggaaa ac //