LOCUS       c00018_gnlPro..        15477 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MEBHALAA_18.
ACCESSION   c00018_gnlPro..
VERSION     c00018_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 18:12:22
            Original ID  :: gnl|Prokka|MEBHALAA_18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15477
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15477
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2360:5477]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2361..5477
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..15477
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15477
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             271..786
                     /locus_tag="ctg18_1"
                     /transl_table=11
                     /translation="MLAWLPFFLISLMFIVLLYACARSARTNIQRFKQLSLIAFLWVLT
                     AFCYTPTSYNFGTQLVIQYIQWGPVKLNVIPFQQLDIEFWLNVLLTVPLGGLLAWNFPD
                     LPWRRFIWLGFLTGLTLELGQFILDWLVNLKRWVDIDDVITNWAGVIIGAAGYKIARHV
                     PGLRWLQK"
     CDS             complement(954..1943)
                     /locus_tag="ctg18_2"
                     /transl_table=11
                     /translation="MRMLEKIEQYIDSCIEAGDIYGASFSLITPKGINQYYHGKQGRDE
                     FAVGLDPAMIYDLASVTKVVGTTTRIFQLLSDHTIHLTDSVARFLPGFTHPEITIKNLL
                     LHNSGLPADIDNLDKMQREDLIKAVYDAPLVTAPGTTYVYSDLGFILLGWIIRAVDGSL
                     ARSIQDHVCYPLAMTNTGYNLNRPKIRFVPTEFDPRRGQIQGQVHDYKAFLLNGESGHA
                     GLFSTLTDLSVFIEMMLNFGEYQGKRVLDENVFDWLGEYDENGRTLGWERRAGRHQYFH
                     TGFTGPAVAFDLDRQIGLVVLTNRVYPTSDNQVWNQDRKRVFDLFFES"
     CDS             2361..4619
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_3"
                     /sec_met_domain="Gly_radical (E-value: 3.8e-40, bitscore:
                     126.9, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 6.3e-247, bitscore:
                     810.7, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITSEKTTKPAAWKGFKGGHWQEEINIRDFIQNNFTQYNGDESFL
                     AGPTAATKTLNDKVLELKKQERAAGGVLDADTKVVATITSHGPGYIQKDLEKIVGLQTD
                     KPLKRAFMPFGGIRMADDALKSYGYTPDEENDKIFTEYRKTHNQGVFDVYTPDMRKARH
                     YKIITGLPDAYARGRLIPDLPRVAVYGIDRLMEDKANDFAHIGDGELTDDVIRLREEVQ
                     DQYRALADMKKMAASYGYDISKPATNAQEAIQWMYFAYLAAIKTQNGAAMSVGRIDTTM
                     DIFIQRDLDNGVLDESQAQELIDQFVMKLRMVRFIRTEEYNSLFSGDPIWATLSMCGLG
                     VDGQHHVTKTAFRILKTLDNMGAAPEPNITILWSDRLPEDFKRYATEVSIDSSTIQYEN
                     DDLMRVQWGTDYYGIACCVSAQPIADGIQYFGARANLAKAILYAINGGRDEIAGDQVGP
                     AYEPITSEYIDYDEFMKKLDKQMDWLADTYVNSLNAIHYMHDKYYYEAAQLALKNTDLD
                     RTFATGISGLSHAADSISAIKYGHVKVIRDERGIAVDFKADNDYPRYGNNDDRADDIAK
                     WLVKELYSKMNTHHLYRNAKLSTSVLTITSNVVYGKNTGTTPNGRQKGEPFSPGANPAY
                     GAEKSGALASLLSTAKLPYRYATDGISNTFGVTPNTLGHDLESRKDTLVNMLDGYMKND
                     GMHLNINVFNKDTLIDAQKHPEEYPTLTVRVSGYCVYFADLTKEQQDDVISRTFFESM"
     CDS             4656..5477
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 74; E-value:
                     4.8e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_4"
                     /sec_met_domain="Radical_SAM (E-value: 6.1e-28, bitscore:
                     88.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKQVSTTQAAAKEPLIGYVHSIETFGSVDGPGIRYVAFLQGCH
                     MRCQYCHNPDTWKLNVGDQMTADEILEDAAKYRAFWGKTGGITVSGGESLVQIDFILDL
                     FEKAKAMNISTCLDTSGQPFTREQPFFDKFERLMKVTDISLVDIKHIDSAKHKQLTQYG
                     NENILDMIQYMAQHHDDMWIRHVLVPQRTDYDEDLKKLGDYIAKIPNDVVQKVEVLPYH
                     TLGVKKYHEMKIKYRLEGIESPTQDRVANAEKLLHTADYNGYKTWMPLPKL"
     CDS             complement(5702..6013)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FeS_assembly_P"
                     /gene_functions="other (smcogs) SMCOG1048:Iron-sulfur
                     cluster assembly protein (Score: 67.1; E-value: 3.9e-21)"
                     /gene_kind="other"
                     /locus_tag="ctg18_5"
                     /sec_met_domain="FeS_assembly_P (E-value: 1e-21, bitscore:
                     67.1, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTFKDRAFEALGHVIDPELGIDLVNLGLIYDAQLTAEGTAEIT
                     MTLTIAGCPLTEWLAKDIHDELIKLPEVNNIEIEIVWEPAWNESMMSREARMELGIHS"
     CDS             7074..7994
                     /locus_tag="ctg18_6"
                     /transl_table=11
                     /translation="LKTINLGHSNIQASSVALGIMRMDALDVAQATKVIDTAADLGINY
                     VDSADIYGGGQSSTIFGQALKQAHVSRDQLYIQSKGGIVPGKRYDFSKQHILAAVDGEL
                     QRLGVDYLDTFLLHRPDALMEPEEVAAAFDKLQTSGKVRHFGVSNFNPMQVDMLQAALN
                     QRLIINQLQFGIMHTGAIDFGLHTNMQDERSLNHDGEMIEYSRLHKMTIQAWSPYQYGN
                     FAGIFLDNPKFPELNNAMQALADEKQVTKSAIATAWILRHPAHFQVVLGTMNPEHLAQN
                     AAGADVTLSRQEWYDIYFAAGNDLP"
     CDS             8164..8688
                     /locus_tag="ctg18_7"
                     /transl_table=11
                     /translation="MTSTCTICERIKLIQAHQNPYFVYELTTGYVVLADSQYFEGYTLF
                     LAKHHVTELHHLPAHEKLRYLEEMSIVQEACAQAFHADKMNIELLGNGDAHVHWHLFPR
                     HNGDTPNPGPVWWTPLETIYGDDVSLDIPRLSRLKRTLSVAIEATLNAREAELQALEAL
                     TRPASHRIDSN"
     CDS             complement(8783..9028)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GlcNAc_2-epim"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_8"
                     /sec_met_domain="GlcNAc_2-epim (E-value: 3.3e-05, bitscore:
                     13.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAPLSSFEKNIPAVTELLAVDAELQTFFVALTPGYQREWARFI
                     FGTKAQATKERHIEVMKTVFRAGYKSKRAYDSRPDK"
     CDS             9201..9629
                     /locus_tag="ctg18_9"
                     /transl_table=11
                     /translation="MPKFDITLISPERAKAMLTEYKEQRKNSVPHLAHPGRYILPDYKL
                     TRRRAAFKIVKHTFLTPHYKSYVAMDSDNGHTLWFHNFGSLTEALFWLETGLKISDTDS
                     HSNYKEWMAKHTTEIETFKDLLREQKHKQGPKTKKKAK"
     CDS             complement(9732..10373)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lipase_GDSL_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_10"
                     /sec_met_domain="Lipase_GDSL_2 (E-value: 4e-20, bitscore:
                     63.0, seeds: 1564, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAISNGHVSFKRPAWLGDSITANNGLATVHYHDILAADWDVERSD
                     NLGISGSTIGSRYDAMAVRYQAIPEDADFIAVFGGVNDYGRDQPLGQYGDCDMTTFYGA
                     LMMLLTGLQTNWPTVPKLFISAIHIGSDFGGSFSAVTNGLGYRQSDYEAAIAQMTADYG
                     VPHLSLYRDAGMTFAIPAQAAIYSVDTLHPNNAGHRVIARKLQSFLDSHF"
     CDS             complement(11079..11342)
                     /locus_tag="ctg18_11"
                     /transl_table=11
                     /translation="MDFHNTSLLRLAHLFEIMVERCLYLKSTTTSLGPLETVPVSVNLL
                     SSFVLRRSPGISANCWNAVDTDLSRRPRLKYWSSTNQSKDAC"
     CDS             complement(11389..13056)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BCCT"
                     /gene_functions="transport (smcogs)
                     SMCOG1001:betaine/carnitine/choline family transporter
                     (Score: 410.4; E-value: 2.8e-125)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_12"
                     /sec_met_domain="BCCT (E-value: 7.3e-126, bitscore: 410.4,
                     seeds: 90, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSSRFIILKSKNIDWWVYLPTIGLFAAASVVLLMGGHSLETSLS
                     GILNWLTNNMSWLYMSVYVITFIFFIYLGFSKLGKTKLGDPDDKPEFSTYHWGSMVYAT
                     GIDASILMLSMVDPLRYLQSPSFGVKPFSTSAYNYAHMLGQFNWGPMAWMMFAPATIAI
                     AYAMYVKHIKVQRLSAAISVLQGPGKGKQIARNTIDFLVIIGIMGGVGTSVGMEIPVIS
                     KVLSAVTGIADTMTLKLGLFALLFVIFAMAVFNGLKKGIGRLSAAHVWLAIGFLIVVLI
                     VGPTLYILNSETNSIGLFVNKFITLSTNTAPNGHATAMQRQTIFYWGWWLSFMPVMGLF
                     IARISRGRTIRQVLGGMLLWGSLGCVSFYAILGGYALYLQRMGIVNLVHILNTQGQAAV
                     IAAVLSTLPLKMIMLALYCLSCFIFLATTVSSFAFITSSFTSKKLAAGEQPSRFNRMSW
                     VVIFLVFSLGLVTVGGFESIQSICAMSGFPLTIVALVLLYSIHHDLTTDPVKEAAKANA
                     KAAELARRKRLARDVEITTKTDYARERRTARKRETEAD"
ORIGIN
        1 tcttgtcaac aacttttttt aagaagtaac ttgattaatt tgtcatagtt gccgttgcga
       61 caacagaaac tatcttacca attactgaag aaattgtcaa caactaattt caataattat
      121 ttggtggtga gatgcatctg ccgtagcagc aacgtttact aatataccaa ttgaagtaaa
      181 aagtgtcaac actttttctg aatttctttt tattaatagt caaaccagct ttctttctct
      241 atactattta attaaaggag cgactaaatt atgctagctt ggctaccatt ctttttgatt
      301 tcattaatgt ttattgttct actatacgct tgtgcgcgat cagcgcgcac aaatatccag
      361 cgttttaagc aactcagttt aattgccttt ctctgggtct taactgcttt ttgctataca
      421 cctaccagtt acaattttgg tacccaactc gttattcaat atattcaatg gggacccgtt
      481 aagctgaacg tgattccttt ccaacaactt gacattgaat tttggctcaa cgttctcctc
      541 actgttccat tgggcggttt actggcatgg aattttcccg acttgccttg gcgtcgtttt
      601 atttggttgg gatttcttac ggggctaaca ctcgagctgg gacaattcat ccttgactgg
      661 ttggttaacc tcaaacgttg ggttgatatc gatgatgtca tcacaaattg ggctggtgtc
      721 attatcggtg ccgctggtta taaaattgca cgtcatgttc ccggacttcg ctggttgcaa
      781 aaataacgta tatatagaag caaaaagcaa aatagcgttt gcttagcacc cacaagtgcc
      841 aaacacttca gcggtctagc tgtcatgaaa tcgtaattaa ataagcgtcg cagccttaag
      901 tggctgcgac gcttatttaa tttaactact aactattaat gaagctgcca tcatcaggat
      961 tcaaaaaaca gatcgaatac tcgcttacga tcttggttcc agacctgatt gtcactagtt
     1021 ggataaactc gatttgttaa cacaaccagc ccaatttgac gatccaaatc aaaagcaact
     1081 gccgggccag taaaaccagt atggaaatat tgatgtcgtc ccgcacgtcg ttcccaacct
     1141 aacgtccggc cattttcgtc atactcgcct aaccagtcaa agacattttc atccagcacc
     1201 cgtttgcctt gatattcacc aaagtttaac atcatttcaa taaatacgga taaatccgtc
     1261 agcgttgaga acaagcctgc gtgaccactc tcaccattca acaaaaaggc tttataatca
     1321 tgcacctgtc cttgaatctg accccgccgc ggatcaaact ccgtcggcac aaaccgaatc
     1381 ttcggacgat ttaagttata acccgtattg gtcatcgcta gtggatagca aacgtggtct
     1441 tgaatactcc gagccaatga gccgtcaacc gcacgaataa tccatcccaa taaaataaat
     1501 cccaggtctg aatagacata cgttgtccct ggtgccgtga cgagtggcgc atcataaacc
     1561 gctttgatca gatcttcacg ttgcatctta tccaggttat caatatctgc cggtagccca
     1621 ctattatgaa gtaacaagtt tttaatcgtt atttcaggat gagtgaaccc aggtaaaaac
     1681 cgggcaaccg agtccgttaa atgaatcgtg tggtccgata acaactgaaa aatcctcgtc
     1741 gtggtcccta caaccttagt taccgatgct aggtcataaa tcatcgcagg atctaagccc
     1801 acagcaaact catcgcggcc ctgcttacca tgatagtatt gattgatacc tttaggggtg
     1861 atcaagctaa acgacgcccc ataaatgtcg ccagcttcaa tacaactgtc aatatattgt
     1921 tcaatttttt cgagcatccg cattacgccc acctttcact acattcacta gtttctgctt
     1981 atcttcttta tgataacgaa cttcctcata aaatcaacgg caaacgcttt taacaccctc
     2041 cacacctcgt tgcacttttt attaattaac tagttaaaca cttgttacat tatggacaat
     2101 attccactta tatatcaaaa cgagtcttgt ttttagccgt tttctaaata taattaagtg
     2161 aattaccaat gcctatctag ctatgtaagt actgttatat caacgttaat agtcaacttt
     2221 tcaataatag attgcaaaaa aataacccaa acgtgaaata aatcacctga aagcggttac
     2281 aaatccagca aaaaatgtta tgattcaaat atagaatttt atcaatcatt tgattggatt
     2341 caaattatgg aggcgagaaa atgattacat cagaaaagac aacaaaacca gcagcttgga
     2401 aaggtttcaa aggcgggcac tggcaggaag aaatcaacat tcgtgatttt attcaaaata
     2461 acttcacaca gtacaatggc gacgaaagct tcctggccgg accaacagcc gctactaaga
     2521 ccttgaatga caaagtctta gaattaaaga aacaagaacg tgccgctggt ggtgtgttgg
     2581 atgctgatac taaagtcgtt gcaacgatta cttcacacgg ccctggttat attcaaaaag
     2641 atctcgaaaa gattgttggt ctccagactg acaagccttt gaagcgggcc ttcatgccat
     2701 ttggtggtat tcgaatggct gatgacgctt tgaaatcata cggttatacc cctgatgaag
     2761 aaaacgacaa gattttcact gaatatcgca agactcataa ccaaggcgtc ttcgatgttt
     2821 atactcctga catgcggaaa gcacgtcact acaagatcat caccggacta ccagatgcat
     2881 acgcacgtgg ccgtctcatt cctgatcttc cacgggtcgc tgtttatggg atcgatcgtt
     2941 taatggaaga caaagctaat gactttgccc acattggtga tggtgaattg actgatgatg
     3001 ttattcgcct ccgtgaagaa gttcaagatc aataccgtgc tttagcagat atgaagaaga
     3061 tggctgccag ttatggctac gatattagca agcctgcaac taatgctcaa gaagctattc
     3121 aatggatgta cttcgcttac ttagctgcta tcaagaccca aaacggcgct gcaatgtccg
     3181 ttggccggat tgatacaacg atggacatct tcatccaacg tgacttggac aatggtgttc
     3241 tggacgaaag ccaagctcaa gaattaattg atcaattcgt catgaaacta cggatggttc
     3301 ggttcatccg tactgaagaa tacaattctc tcttctctgg tgacccaatc tgggcaacct
     3361 tatcaatgtg tggtttaggc gtcgacggtc aacaccatgt gactaagact gctttccgga
     3421 ttttaaagac tttggacaac atgggcgccg caccagaacc aaacatcacg attttatggt
     3481 cagaccgctt accagaagac ttcaaacgtt acgcaactga agtttcaatc gacagttcaa
     3541 ccattcagta tgaaaatgat gacttgatgc gggtacaatg gggtaccgat tattatggca
     3601 ttgcttgctg tgtttccgca caaccaattg ctgatggaat ccagtacttc ggtgcccggg
     3661 caaacttagc caaagcgatt ctttatgcca tcaatggtgg ccgcgacgaa attgctggag
     3721 atcaagttgg ccctgcttac gaaccaatta cttcagaata catcgattac gacgaattca
     3781 tgaagaaatt agacaagcaa atggattggt tagctgacac ttacgttaac tcactgaatg
     3841 caattcatta tatgcatgat aagtactact atgaagctgc ccaattagct ttgaagaata
     3901 ctgatcttga tcggaccttt gcaactggga tttctggctt atcacatgcc gcggattcaa
     3961 tctcagctat caagtatggt cacgttaaag taattcgtga cgaacgtggt atcgccgttg
     4021 acttcaaagc cgacaatgac tacccacgtt atgggaacaa tgacgatcgc gctgatgaca
     4081 ttgctaaatg gttagtcaaa gaattataca gcaagatgaa cacgcatcac ctctatcgga
     4141 atgccaaact ttcaacttct gttttgacga ttacctccaa cgttgtttat ggtaagaaca
     4201 ctggtaccac gccaaatggc cgtcaaaaag gcgaaccatt ctcaccaggt gctaaccctg
     4261 catacggtgc tgaaaagagt ggtgcattag cttcacttct ttcaactgcc aaattaccat
     4321 accgttacgc aactgacggg atttccaaca cgttcggcgt tacccctaac acgttaggcc
     4381 atgacctcga atcacggaaa gacacgttag taaacatgtt agacggttac atgaagaacg
     4441 atgggatgca cttgaacatc aacgtcttca ataaagacac tttgattgat gctcagaaac
     4501 accctgaaga atacccaaca ttaacggttc gggtttctgg ctattgtgtc tacttcgcag
     4561 atttaaccaa ggaacaacaa gatgacgtta tttcacggac attcttcgaa tcaatgtaac
     4621 atttaatctt taatagttaa gaaggcgaaa ggctcatgga aaacaaacaa gtttcaacaa
     4681 cgcaagcggc ggcaaaggag cctttgatag gctacgttca ctccatcgaa acgtttggct
     4741 ccgttgacgg accaggtatc cgttacgtgg cattccttca aggatgccac atgcgttgcc
     4801 aatactgtca caaccctgat acttggaaac tcaacgttgg cgatcaaatg acggccgacg
     4861 agattctcga agacgcggct aaataccggg ctttctgggg caagacgggt ggcatcacag
     4921 tcagtggtgg tgaatcactg gtacaaatcg acttcatctt agacttattc gaaaaagcca
     4981 aggcgatgaa tatcagtact tgtctggata cctctggaca gccttttacc cgagaacaac
     5041 ctttctttga caagttcgaa cgtctaatga aggtcacgga catttcgttg gtcgacatta
     5101 agcacatcga ttctgccaaa cacaagcagt tgacccagta tgggaacgaa aatatcttgg
     5161 atatgattca gtacatggcc caacaccacg atgatatgtg gattcgtcac gtcctggttc
     5221 cccaacggac tgattacgat gaagacttga agaaactcgg cgattacatt gctaaaattc
     5281 caaacgacgt cgttcaaaaa gtcgaagtat tgccgtacca tactttgggc gttaaaaaat
     5341 atcatgaaat gaagatcaag taccggcttg aaggaatcga gtctccaacc caagatcggg
     5401 tggcaaatgc cgaaaagcta ctgcacactg ctgattacaa cgggtacaag acatggatgc
     5461 cattgccaaa actttaaatc ggcatttcta gcatgactaa aacaccagcg atacaatcgt
     5521 ctacggatgg ttgtgtcact ggtgtttttt tgctggctcg acgcatacac gtattgcggg
     5581 ctggaattag cacagcggca cgcaaaaaag gcgccgcgag cctaaaccag caacgtcttt
     5641 ccttaatcat gccctatcca atgaccgtca gcccttggac tggctgcgaa caggccggcc
     5701 actaactatg aatgcctagt tccattcgag cttcgcggga catcatactt tcgttccaag
     5761 caggttccca cacaatctca atctcgatat tgttaacttc tggtaatttg atcagttcat
     5821 cgtgaatgtc cttagccaac cattcggtca aaggacagcc cgcaatggtc aacgtcatgg
     5881 taatttcagc ggtcccctcc gccgtcaatt gtgcatcata gatcaacccc aagttaacta
     5941 gatcaattcc taattcaggg tcaatgacat gtcctagcgc ctcgaaggcc cggtctttaa
     6001 acgttgttgt catcgtatct cgtccttcca taccagcttg aattcactga ttaatcacgc
     6061 caacgtttcg cggtataagt gccaccacac ttgatacacg tcatcgttat ataaagcgct
     6121 ttcttgtcta cttctattgt accgtatgtc agcccatatt caatcaatta ttagcgctaa
     6181 ttaaccgact tttcaaacgg tcggtcaatc agcaaattat gcgactattt ctcgaaaaaa
     6241 attcactata atccccgata tagcagcgtt ttgagtcact attgattttt attgcgaatt
     6301 cacggttgtt tttgttgtaa gcgtttgcgg tttatgctat tatactaagt gaggaaagga
     6361 attaatcctc gattagcaaa gcttctcaaa agagtttggc tgtcgctgta atgttagaca
     6421 gctagtatca cagtttgggt cgttatcgaa accgttttaa gcgccgtgaa gcgttatcgg
     6481 tctagcgagt gtcgtgagat ttacgttgga tgactgaacg ttgaccctta gataaacgat
     6541 aaccgcaaag aattaattgg cattagaatg acgaacagat tttaactaag ttttagttgg
     6601 aaacaggtgt ctccgatgac cagttgttag ttccacatta ccagttccat ttgtagactc
     6661 aggtattaca aagtttaaac ggaggtgcat gtctgttacg aagacattcc caagttttaa
     6721 acgcgagttt gactttcgtt aaaacccgtc taacgagtcg caatcaagta acaaccttac
     6781 tttagatcga ctatagcaga tagttacaat aaatacgggt tagtccgtta gaagttggac
     6841 acgcgtaaaa ttgaatagca tgaaggtgta tcatattaac actgaacaat ttttcattgc
     6901 taatcaggat tattcctcat aagtagaact caagcagaga agccttgggt tctatttttt
     6961 tgctctaaaa tcagatttac caacagtcgg caccagacgt aaccgtttac atcctcttac
     7021 gaaaaccgta tactgaattt aaatcaagtt gcacattgag gaggacttta gttttgaaaa
     7081 cgattaattt aggtcacagc aatattcaag cttccagcgt ggcgcttggc atcatgcgca
     7141 tggacgcctt ggatgtcgct caagccacca aggttatcga taccgctgct gatttaggca
     7201 tcaattacgt tgattcagct gatatctacg gtggtggtca atcatcgacc atcttcggtc
     7261 aagcactcaa gcaggctcac gtatcgcgtg atcagctcta tattcagtca aaaggcggca
     7321 ttgttcctgg caagcgttac gacttttcca aacagcacat actggcagcc gtggatggcg
     7381 agcttcaacg cttaggtgtt gattatctcg acaccttcct cctccatcga ccggacgccc
     7441 tgatggaacc cgaagaagtt gctgccgctt ttgacaagtt gcaaactagc ggcaaggtgc
     7501 gccactttgg cgtctctaac ttcaatccca tgcaagttga catgcttcaa gcggcactaa
     7561 accaacggct catcattaac caactccaat ttggtatcat gcataccggt gcgatcgact
     7621 ttggcttgca cacgaacatg caggacgaac gtagtcttaa ccacgacggc gagatgatcg
     7681 aatactcacg gctccataag atgacgattc aagcttggtc gccttatcaa tacggtaact
     7741 tcgcgggtat cttcttagac aatccgaagt ttccagaact taataatgcc atgcaagcac
     7801 tcgccgatga gaaacaggtc actaaatcag ctattgcgac cgcatggatt ctccggcacc
     7861 cagcccactt ccaagtcgtc cttggtacga tgaatccgga acatctagct caaaatgctg
     7921 ctggagcaga cgttacgctt tctcggcaag aatggtacga catttacttt gcagctggca
     7981 acgatttacc ttaatcacga tcgacctaac agaattgacg attagttttt acaatcaaaa
     8041 cgacgacccc aaatcaggat tgattttcag gtcgtcgttt tttagacgtt tcactaacat
     8101 ttttgatgta ctcaccacat ctacgcgtat acttaatctt atcaagactc aggaggcgag
     8161 cgaatgacat ccacttgcac gatctgtgaa cgaatcaaac taattcaggc acatcagaat
     8221 ccttatttcg tttacgaact cacaacgggc tacgtggtcc ttgctgatag ccagtacttt
     8281 gaaggctaca cgctcttttt agccaaacat cacgttaccg aattacatca tttaccggca
     8341 cacgagaagt tacgatacct tgaagagatg agtatcgtcc aggaagcttg tgcgcaggcc
     8401 tttcatgcag acaaaatgaa cattgaacta ctcgggaatg gtgacgcgca tgttcattgg
     8461 cacttatttc ctcgccataa cggtgatacg cccaaccccg gtcccgtctg gtggacaccg
     8521 ctggaaacaa tttatggtga tgatgtcagt ctagacattc cccgtttaag ccggttgaag
     8581 cgcacgctca gcgtagcaat tgaggccacg cttaatgctc gggaagcaga attgcaggct
     8641 ttagaggcac tcacaaggcc tgctagccac agaattgaca gcaattagac caaatcagga
     8701 cccagacccg cttagatctt ggtggctaca ccccaattct taatcgcaat ccgtcaccgt
     8761 atttcaaatt gccaaaatcc acctatttat ccggccgact atcatacgct cgcttagatt
     8821 tatagccagc tcgaaaaacc gtcttcataa cttcaatgtg ccgttcctta gttgcttgtg
     8881 ccttagttcc aaaaataaag cgggcccatt cgcgctgata accaggtgtc aaagccacaa
     8941 agaacgtttg caattcagca tcaaccgcta acaattcggt taccgccgga atattttttt
     9001 caaatgaact gaggggtgct gtactcataa tcaaacctcc gattagtttt acttaaattt
     9061 actgtaagaa agggaaaatc cctaattttc aggtttttat atttcgaatt ttcataaaat
     9121 tgcgctatca ttatagtata agtattatta tttgactact ataattaacc atactgctat
     9181 tcaccaaggg gagccctgct atgccaaaat ttgatatcac cctcatcagt cccgaacgcg
     9241 ctaaagcgat gttgactgaa tataaagaac aacgtaagaa ctctgtccca catctggccc
     9301 atcctggccg ctatatcttg ccggattaca aattaactcg tcgccgggcc gcattcaaaa
     9361 ttgttaaaca taccttttta acgccccact acaagtctta cgttgccatg gactctgaca
     9421 acggccacac actctggttt cataatttcg gttccctaac cgaagcttta ttctggttag
     9481 aaaccggcct taaaatcagc gataccgact cccattctaa ctacaaggaa tggatggcta
     9541 agcacactac ggaaatcgaa accttcaaag acttgctgcg cgagcagaag cataaacaag
     9601 ggcccaagac taagaaaaaa gccaagtagc ccgttttgac acctagattc agataagcag
     9661 cagtacgctc attagcgtgc tgctgctttt atttacgatc aactgtgcca ttcattactg
     9721 actaggccaa cctaaaagtg gctatccaaa aacgactgca gcttgcgtgc aatcacgcga
     9781 tgaccggcat tgttcggatg caaagtatcc accgaataaa tggccgcttg agcgggaatc
     9841 gcaaacgtca ttcccgcatc acggtacaag ctcaaatgtg ggacgccata gtctgcagtc
     9901 atctgggcaa tcgctgcttc ataatctgac tgacgatacc cgagaccatt agtcaccgca
     9961 ctaaaactgc ccccaaaatc agagccaata tgaattgctg aaataaataa cttcggcacg
    10021 gtcggccaat tcgtctgtaa tcccgtcagt aacatcatta acgcgccata aaatgtcgtc
    10081 atatcgcaat caccgtattg ccctaacggc tgatcccgac catagtcatt gacgccccca
    10141 aagacagcaa taaaatcagc atcttcagga atagcttgat agcgcaccgc catcgcatcg
    10201 tagcgactcc caatcgttga accagagatt cccaaattat cgctccgctc gacatcccaa
    10261 tcagccgcca aaatatcatg ataatgcacc gtcgccaacc cattattcgc cgtaatcgaa
    10321 tctcccaacc acgccggccg cttaaaacta acatgcccat tactaatcgc catagccaat
    10381 cctcccttta ctatcatcgc tatcattcta atccatccca cctgaattat ggtagaaaga
    10441 tgccttttag ggttggtttt ctgttcgtca gccggtgagc gtcctattcc gacctccggg
    10501 gctgggtgac aattgctgga acgcagccga catcgatttg agctaacgca taacccgcgt
    10561 catctcaaat acgagtctta ttctaagccg gaaggaaatc acttccgact aagaataatt
    10621 tggctactga gcattgtcac ccagcccctc cagtctcaag ccacgggttg aagccgagca
    10681 ttgtctagcc aacggattaa tgcggtttgg acatttgtcc gttggcatag caagcacaga
    10741 ctttagtggc accgaacacg tttcggtaag ccgcccgaat ggctgatgaa cggccactta
    10801 acttggtgca attggtcgtt ggctattttg ataccggaac tttaaacgag acgttagggt
    10861 taccctaacc actttgttga ggtgttctat tattactata gtaattccga aatagcgagc
    10921 tatcccaata tcttttcgac ctaacagttg attaataaaa ttactgttta tggagaacaa
    10981 tgacaaattc atcaaaagtt gggtatatct tcgtccacca ttcgaatact gtcccgaatg
    11041 gaaggcgttt cggccaatgc tcagcggtga aattccactt agcaagcgtc cttggattgg
    11101 ttagtagaag accagtattt aagacgtggt cttcggctta aatctgtgtc caccgcgttc
    11161 cagcaattgg cagaaatgcc tggagagcgg cgtaggacga acgaactaag caggtttacg
    11221 ctaaccggaa ctgtttccag cgggcctaag ctggtggttg ttgactttaa ataaaggcat
    11281 ctttctacca ttatttcaaa caggtgggcc aatcttaaaa ggctcgtatt atggaaatcc
    11341 ataatacgag cctagtttaa ttgatatatt tagttcaact gagtagcgct aatcggcttc
    11401 cgtttcacgt ttccgtgcgg tacgccgttc gcgtgcgtag tcagttttag ttgtgatttc
    11461 aacgtcacgt gctagccgtt tccggcgtgc taattcagct gctttggcat tggctttcgc
    11521 agcttccttg actggatcag tcgttaagtc gtgatggatc gagtacagta agacgagcgc
    11581 gacaatcgtt aatgggaagc cagacatcgc acagatggac tgaatcgatt caaagccacc
    11641 gaccgtgaca agccccaatg agaagactag gaagataacg acccagctca tccgattgaa
    11701 acgacttggt tgttcccccg cggccaactt tttactagta aatgacgagg taatgaaggc
    11761 aaatgaagat accgtcgttg ctaagaaaat aaagcaagat aggcagtaca aagccagcat
    11821 aatcatcttc aatggtaagg tcgacaatac tgctgcaatc acagcggctt gtccttgcgt
    11881 atttaagata tgaactaagt taacgatgcc catccgttgc aagtataagg cataaccacc
    11941 caagatggcg tagaaactga cacaacctaa tgagccccat agcaacatac caccgagtac
    12001 ctgacgaatc gtccggcccc gagaaatccg ggcaatgaat aagcccatga ctggcataaa
    12061 ggataaccac cagccccagt agaagatcgt ctgccgttgc atggccgttg cgtgaccatt
    12121 tggtgcagta ttcgtgctca acgtaataaa cttattgaca aacaagccaa tactattagt
    12181 ttctgagttt aaaatataca aagttgggcc aacaattaaa acaacgatta ggaagccaat
    12241 cgctaaccaa acatgggcag cacttagccg accgattccc ttcttcaagc cattaaaaac
    12301 agccatggcg aaaattacga ataataaggc aaataaccct aactttaaag tcatcgtatc
    12361 ggcaatcccg gtaacggcac tcaaaacttt tgaaatgacg gggatttcca tcccgactga
    12421 agtaccaaca ccacccataa tcccaataat aacgagaaaa tcaatcgtgt tccgggcaat
    12481 ttgcttaccc ttaccaggac cttgtagtac tgaaattgca gcactgagcc gctgaacctt
    12541 gatgtgttta acatacattg cataggcaat tgcaatcgtg gctggcgcaa acatcatcca
    12601 cgccattggt ccccaattaa attgtcccag catgtgcgca taattatatg cagaagttga
    12661 aaacggcttg acgccgaatg aagggctttg gaggtaccgt aacgggtcaa ccatgctcaa
    12721 cattaagatg ctggcatcga tcccggtcgc gtaaaccata ctgccccagt gatacgttga
    12781 aaattctggt ttgtcatcag gatcaccaag tttggttttc cctaacttac taaaccctaa
    12841 gtaaatgaaa aagataaaag tgatcacata taccgacata taaagccagc tcatgttatt
    12901 tgtgagccag ttcaagatgc cacttaaact cgtctccagc gaatggcccc ccattaataa
    12961 aacaacggaa gccgccgcaa agagcccaat tgttggtaaa tagacccacc aatcaatatt
    13021 cttacttttt aaaataataa acctgctact gagcatatac tctctatatt tagatcaaat
    13081 tcgtggttct tcctaccagc aatggtagtc cccacgcgta aatttccgac tagcaatcgg
    13141 tacacccctc cgagttaatc ctcggagcac tcagcaccct gactgtatca ggtttgaccg
    13201 gcattgtcat ccgcattctg tttgtgctaa ctcaaaatca gtagcagaat ttccttcttt
    13261 ccgttggttg aatccggaca acgccatact gacaaatgat ttttaattgc ttaatcgacg
    13321 ttggtgttca tcttgtttag ctagtgtttc tattaccatc gtgcctttag cacacgaccg
    13381 tcgtcacacc acgtaacgat taatggttac actgctcttg ctaatagata acccccttga
    13441 atcaccagat aagcccaccg cacaactgtt agattaattg cttggtgcac caaaaaagcg
    13501 cttagtaccg ggtaacaagt taccacctgc acagcgcacg ttggcttata caaatgctga
    13561 tttcagtatt ttctgatatc tgatgttcgt ttataagtat actagtatta aatcagaagt
    13621 aaaatcaacc attttgagcc gtcgaggcct aacccgtcaa ggattagacg agttttacac
    13681 ccatattttt tctgaaactt tttaaaagtt ttcgtaataa ttagttttta gtttagaatc
    13741 attcttatct gtttcaatta aaccgatttc atgttattct tgtaacaagt aaaaaaacgt
    13801 tatcatctaa aaggagggga actgcatgcg gcactactat aaattaattt taacggtcag
    13861 cgtcggtatc attgcggtta ttttacagtt tggtttgcac taccaattgg cagcacaaat
    13921 catcattaca ttaatggggt cacttatggc cttatcaatg ttagttgaga tgatcaaaac
    13981 cttacgttca ggtaagtacg gggttgattt attagcaatt acggcgattg tggcaacact
    14041 agctgtcggc gaatattggg ctagccttgt cgttctaatt atgctcactg ggggtgactc
    14101 gttagaagat tatgcggcca aacgagcgaa taccgaattg aaagccttgc tcgataattc
    14161 accacgtatt gcccaccgct cagtcgccgg ccaattaaca gatattgccg ttgaagatgt
    14221 ccaaattggt gatcagctag tcgtcaaacc tggtgagcta gttccagtag acggtcacct
    14281 tattcaagga acggcactct ttgatgaatc ttcattgacg ggtgaatcta agccagtcga
    14341 caagcacgtt ggcgatgaca ttatgtctgg tgcggtcaac ggcgatagtg ctgttacaat
    14401 ggttgttgat aaattagcca ttgatagtca ataccaacag ttagtcaaat tggttaaaga
    14461 atccgaatca cgaccagcca aattcgtacg gctggccgat cgctatgcag tcccattcac
    14521 cttggtagca tacgtcattg ccggagtagc ttgggcattc agcggtgatc cccaccgatt
    14581 tgcagaagtc ctcgtagtgg cttcaccttg cccgctgatt ctcgccgcac ccgttgcact
    14641 cgtctcaggg atgagccgaa ctagtcggaa cggaatcgtg gtcaagactg gggacatgtt
    14701 ggagaagtta tctacggcta agtccgccgc gtttgataag acggggacca ttaccagtgg
    14761 tcaattaaca gtcaaccaaa ttgttcctca gcctggtttt actgccgaac aaatcttgca
    14821 cctcgcagcg agcgctgaac aaaactcaag tcatatcctg gcccgctcac tcgtcaagta
    14881 tgcgagtgcc actagcctca gcccggcaac acaattagca gaagtaacgg gtaatggggt
    14941 cacggcaacg attgagcagc aacaggtcaa agtgggcaaa cttaaattcg tcgcaccgac
    15001 tacaaccgcc aagccacttg ctaccactgc tatctacgtc ggcattgatg accagtacgc
    15061 gggttacatc acgtttatcg acaatgtccg ccccgaagca gccgccacgc ttcaagcact
    15121 ccacgctgag ggcgttcaaa acgtcatgat gcttactggt gaccaacagg caattgctga
    15181 tcatattgcc gccgatgtcg gtatcgatac cgttgctgcc gacctcctac ccgcagataa
    15241 aattgcccac ttaaaggctg taccagcggg cgaacgcccc gttatcatgg ttggcgatgg
    15301 tgttaacgac gcgccttccc tggctgttgc tgacgtcggc atcgccatgg gcgcccatgg
    15361 ctcaactgct gctagtgaat cggccgacgt cgtcatctta aaagacgatc ttagtcgcgt
    15421 ggtcacggcg gtgcgcattg ctaaagatac catgcaagtg gctaaacaag ccgtttg
//
