LOCUS       c00012_gnlPro..        16202 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JEGFKIBI_12.
ACCESSION   c00012_gnlPro..
VERSION     c00012_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-30 18:34:03
            Original ID  :: gnl|Prokka|JEGFKIBI_12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16202
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16202
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2957:6202]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2958..6202
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16202
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16202
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(903..1835)
                     /locus_tag="ctg12_1"
                     /transl_table=11
                     /translation="MTTLIFGHQNPDTDAITSAMSWAEFQKQAGNTDVEAVALGEPNDE
                     TKFVLDHFKVQAPRVIKTAANETDHVMLVDHNEFQQSVSDIEDVTIDSVVDHHRIANFH
                     TAAPLFYRAEPVGSTNTVIFEMFQEYGFKISPTLAGLMASGLISDTLLLKSPTATDKDK
                     KILPEMAKIAGIDLQSYGLAMLKAGTNLAAKSDMDIIEGDAKSFTMGGKSIRIGQVNTV
                     DLNDIYARQDELISAMTKEAQAKGYDDFLLIATDILDSNSTGFAVGADRDKIASAFNEQ
                     FDKDARLALPGVVSRKKQVVPPMQSTFEG"
     CDS             complement(1865..2833)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     60.8; E-value: 3.2e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg12_2"
                     /sec_met_domain="LysR_substrate (E-value: 4e-26, bitscore:
                     85.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 1.4e-18, bitscore: 60.8,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKQERIFSSKTLTYFLQLAETMNYTQAAQLLGITQPALTQQIK
                     KLERTVGAPLFYSVGKKLHLSDAGQTMLKSTHEIYEILNQTTDEIQQTTSATVGKINIG
                     LLSSIEDSAFIAFIAHYYQLNPEVEVTLRMMTRHEIWESLENNQIDLAIMNLPDETIKN
                     WKPYASKKIIDEQLLFLHHDDALANRKRIHFKDTLAEPWATYPDDYFLGQLLREAYKNQ
                     MVDFPHVVAHFTTPYQLTQFVNLSGVNTALPTSFVRARADQIKAYAIAFDPAIRFEISF
                     VYRKEKADIPRISNFFQTFDDYLKEKDYLSRVSENRVKLDK"
     CDS             complement(2958..3809)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 65.2;
                     E-value: 2.4e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_3"
                     /sec_met_domain="Radical_SAM (E-value: 6.9e-25, bitscore:
                     82.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLIDQSQSPLNILEQVGQDHDGPIKGYVHSVESFGSVDGPGIRF
                     VVFMQGCRMRCQYCHNPDTWNIGVGEEMTADQILADAQRYKAFWGDQGGITCSGGESLV
                     QIDFILELFTKAKALGISTCLDTSGGPFTRDQPWFGQFEKLMAVTDISLVDIKHIDSAE
                     HKKLTGFPNENILDMVQYMSAHGDDMWIRHVLVPERTDFDPYLKRLGDYIATLDKNVVQ
                     KVEILPYHTLGVKKYHELGITYPLEGIEPPSADRVKNAENLLHVKDYTGWQSWRPKPVA
                     SN"
     CDS             complement(3941..6202)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_4"
                     /sec_met_domain="Gly_radical (E-value: 1.1e-40, bitscore:
                     132.6, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 4.5e-243, bitscore:
                     802.0, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQLDETKVPNYWEGFNGGDWQEEINVRDFIEHNLNQYDGDESFL
                     AGPTEATTVLNNQVLNLKKQERANGGVLDADNNIPSTITSHGPGYLNKDLEKIVGVQTD
                     KPFKRAFMPFGGIRMAEDALESYGFKTDPQEHKIFNEYRKTHNQGVFDAYTPDMRKARH
                     YKIVTGLPDAYGRGRIVSDFPRIAVYGIDRLMAEKFKDYNLTGDGEMTDDVIKLREEIN
                     EQYRALNDMKKMAKEYGYDISRPAANAQEAVQWIYFGYLAAVKTQNGAAMSVGRIDTVI
                     DAYIQRDMRLGKLNEEQAQELIDHLVMKLRMVRFIRTEEYNSLFSGDPIWATLSLAGMG
                     NDGRHHVTKTAFRFLKTLDNMGAAPEPNITLLWSERLPEGFKRYATEVSIQSSTIQYEN
                     DDLMRNEWGTDYYGIACCVSAQPIADGVQYFGARANLAKTVLYAINGGKDEIQEAQVGP
                     EYAPITSDYIDYKEFMNKFDKMMDWLADTYVNALNVIHYMHDKYYYEAAQLALKDTQLN
                     RTFATGISGLSHAVDSISAIKYGHVKAIRDENGVAVDFVADNDDYPRYGNNDDRADDIA
                     KWLVKTFYNKMNTHHLYRGAKLSTSVLTITSNVVYGKNTGTTPNGRQKGEPFSPGANPA
                     YGAEKNGALASLMSTAKIPYHYATDGISNTFGVTPNTLGHDDETRKDTLVHMVDGYMEN
                     SGMHLNINVFNKETLIDAQKHPEEYPTLTVRVSGYCVYFADLTKEQQDDVIARTFFEEM
                     "
     CDS             complement(6454..8898)
                     /locus_tag="ctg12_5"
                     /transl_table=11
                     /translation="LANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRI
                     LFAMNQDGNTYDKGFRKSAKSVGNVMGNYHPHGDSSIYEAMVRLSQDWKLRAPLIQMHG
                     NNGSMDGDPPAAMRYTEARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGFPNL
                     LVNGATGISAGYATEIPPHNLREVIAAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQG
                     LDGIKQAYETGRGKIVVRSRTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRINKK
                     VDGIAEVRDESDRFGLSVVIELKKEADAHGILNYLFKNTDLQIAYNFNMVAIADMQPKL
                     LGLKAMLEAYVEHRRDVVTRRTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDK
                     GDAKRNLVKKFDFSEAQAEAIVSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPA
                     ARDRVIEGELKRIAKEYGDDRRSSIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSS
                     LRSYQAVDPADNGLKANDLAIFTGELSTLQHLYIVTNAGNVIYRPVHEISDARWKDTGE
                     HLSQTVGLGTDEKVLAVFAFDQLDGAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMA
                     MKLKDPAAIVTNAYFTTDQQQDVFVVSRHAYGLTFPLNDVSTVGARATGVKSMDLKPDD
                     EVVNFILVKDPTTAKVGILTQRGAFKKMALSEVGEMSRARRGLLVLRELKRDPHRIVAM
                     MSVDDATRLNVLTDTGKVTTLNPAQHPAGDRYSNGSFVIDTDVLGKPVFVQTKEEPADQ
                     VE"
     CDS             complement(8905..10917)
                     /locus_tag="ctg12_6"
                     /transl_table=11
                     /translation="MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEI
                     VDNSVDEALAGFGDEINVTIHADNSVTVQDHGRGMPTGMHPSGKPTIEVILTVLHAGGK
                     FNQNSYKTSGGLHGVGSSVVNALSESLTVRVVRDKHAFEEHFINGGHPDGSLQKLGKVN
                     EPNGTTITFKPDPTIFQTTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPD
                     GLVSFVKYLNEGKDALSQVINFEGKKDGIVVDFAGQYNDGYSENLISFVNNVRTGDGGT
                     HEIGLRSGMTRAFNEFARKVGLLKERDKNLEGSDVREGFAGILSVRIPEEILQFEGQTK
                     GKLGTPQARTVVDGIVYDKLSTFLMENGEESQELVRKAVKARDAREAARKARDDSRTGR
                     KRKKDQGLLSGKLTPAQTKNPKRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNT
                     QKAKLQDIVKNEEINTMIYTIGAGVGADFDLQQANYDKIIIMTDADTDGAHIQILLLTF
                     FYRYMRPLIDAGRIYIALPPLYRLQKGAGAKTKISYAWTDEELAKETKAMGKGYTLTRF
                     KGLGEMNADQLWETTMNPETRTLIRVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKF
                     DMDDDGSILETPTANHEKLQFGAKQIVKQLDKKGK"
     CDS             complement(10973..11245)
                     /locus_tag="ctg12_7"
                     /transl_table=11
                     /translation="MVLMPKRAHQPRNLRVRTLGTMVKAQPSRPRPLTLRLLTAPARAL
                     LKRVHQPRNLHIRTLGTMVKAQPSHPRPLMLRFLIGMARALIFYF"
     CDS             11609..12232
                     /locus_tag="ctg12_8"
                     /transl_table=11
                     /translation="LILVLCFILAYFIGAIPFGVVIGKLFYHTDIRKGGSHNIGTTNAY
                     RMLGPVGGSIVLVLDILKGTLAASLPILFGIEHHWLVLIVGLAAVFGHTFSIYIRFKGG
                     KAVATSAGILLAYNPPFFVIAFAIWFSLILLTSMVSVASTLGMVLITAWSLVYHDWLLT
                     TVACGLLVVFLIKHRANFKRIKAGDENMVPFGLGQYLRQHRGRS"
     CDS             complement(12314..13192)
                     /locus_tag="ctg12_9"
                     /transl_table=11
                     /translation="MVTIANDFLTVKISRHGAELTSIKDNLTGRERLWQADPAVWGRHA
                     PVLFPIVGALADNQYHYAGKTYHMGQHGFARDRDFTVLSATPFKASFVLKDDDKTRAMY
                     PFAFRLIITFALENNNLHVTYHVDNPDKSEPLFFSIGGHPGFKVPMTPDTQFSDYYLNF
                     KPRKSLVQIPLVAGEGIDYTHRTLAATDANLALTHETFDHDALIFALLGKTTFNLVSDK
                     TKHGVSVTMTDTPYLGVWSPYPTTGDFVCIEPWWGIADTIGSTGDLTRKLGINRLEPGT
                     AFEKGYMISIF"
     CDS             complement(13228..14637)
                     /locus_tag="ctg12_10"
                     /transl_table=11
                     /translation="MAEVQTPKQIVEKLDQYVIGQDDAKRAVAVALYNRYRRMQLSPKM
                     QEEITPKNLLMIGPTGVGKTEIARRLAKIVEAPFVKVEATKFTEVGYVGRDVESMVRDL
                     AETAVAMEEEKQFSKVRIRAEKEANKRLVKILVPAIRKEKNTNPMAEMMSMLQGMQNGK
                     MPAGDDADAGGEVTDDIRNKRLSVAKQLEKGLLEDHEITVAVNDEKKGGGMGDMYGQMG
                     IDLSDTIGALMPKKKVERTMTVKEAREIFIKEESDKLVNHADIYHDAIQSAENNGIIFI
                     DEIDKIAAGNKHNSGEVSREGVQRDILPIVEGSQINTKYGPINTDHILFIGSGAFAEAK
                     PSDLIAELQGRFPIRVELKDLTEKDFVRILTEPDNALIKQYIALIGADGVKITFTKEAV
                     DRIAEIATQVNHDTDNIGARRLATILEKLLEDVLYEGPDMAMGAVTVTQQYVDDKIGHI
                     AADSNMTRYIL"
     CDS             complement(14681..15205)
                     /locus_tag="ctg12_11"
                     /transl_table=11
                     /translation="MTTIAAVRKDGVTALAGDGQVTLGEKVIMKGNAQKVRRIYHDQVV
                     IGFAGGVADAFTLQDWFEKKLEHYAGNLRRSAVALAQDWRKDPTLQKLEAMMIVMDEHD
                     LLLVSGSGEVIDPDEDVVAIGSGGNFAQAAAIAMLRHAPDMTPADIAKEAVNIAGNIDI
                     FTNHNVIVESF"
ORIGIN
        1 ctattaaatg agttcacttc ggtcaatcat tcagcaaact tattttggcc attggtcaat
       61 aaaataaatt tgctgaatgt tacgtgaccc tcaattgttg ttgagtcaat ttcaaactac
      121 acaactcaaa aaatcatcaa gcaactcgaa gccggctaac tgacgagaat ctcacaacat
      181 catgaagctt gaattgatat gcatttttct ggttttggct agcatgacat tttcaatcaa
      241 acaaatgcat gcaactcagc gtaaacgcaa cgttccaagt cataattgat tgccttggta
      301 aaaaatgcaa tcgccaccac caacattacg tccggaccac aaatttttga cagccatctg
      361 aaagagggga cacccagatt cgcagatcaa gtgccaaagc caattattta tattctagtt
      421 tacataatat atattatgcg aagtagcgtt tgaagagacg gcatcgtgcc attctcgcaa
      481 tatttacgtt ggcgattatt tgattcgcaa tttcatacag cacctgatag tcgcctcatt
      541 ttttgaaccg ctgcttgcag ccaagtcttt aaaagcttct acaatctttg gataaatcat
      601 tggatatttt ttgcttgagt tttttcgtta agtcaaacta tcaagttgaa ttcccgaact
      661 cgtctcagaa tgcgtctctc agcatgcctc aaaaccatcc aaaatgaccc atgacaactt
      721 gctgttgatt cgacccgcga attgctacac aaatttcaaa ttcacgcatc acgaactgct
      781 agccagcttt atatttaaca gatttcgcaa aaagatggct agagactttt tgcaaacaaa
      841 aaagccgcaa ctggctagct gcgacttacc ttagaacaat tgtgtgcaat taaagatgaa
      901 agttaacctt caaacgtgct ctgcattggc ggaacgacct gctttttgcg ggaaacaacc
      961 ccaggcaatg ccaaacgcgc gtccttgtcg aactgttcgt tgaaagcact ggcgatttta
     1021 tcgcggtcag caccgactgc gaaaccagtt gaattgctgt ccaagatgtc agtggcaatc
     1081 agcaggaaat cgtcgtagcc tttcgcctgc gcctctttgg tcatggcact gatcaattcg
     1141 tcctgacgtg cgtaaatgtc gttcagatcg acggtattga cctgtccgat gcgaatagac
     1201 ttgccgccca tggtgaaact cttagcatcg ccttcgataa tgtccatatc tgacttggcg
     1261 gccaaattag tgcctgcctt cagcatggca agaccatatg actgcaaatc aattccggca
     1321 atcttcgcca tttctggcaa aatcttctta tccttgtcgg ttgcggtcgg cgacttcaac
     1381 aacagcgtgt ctgaaatcaa accagaagcc atcaaaccag ccaatgttgg cgaaatcttg
     1441 aagccatatt cctggaacat ctcaaaaatg acggtattgg tgctgccaac cggttctgct
     1501 cggtaaaaca gcggcgctgc cgtgtggaag ttagcgatgc gatgatggtc gacaacagaa
     1561 tcaatcgtca cgtcttcgat atcactgaca ctttgttgaa attcgttgtg atcaaccaac
     1621 atgacatgat ccgtctcgtt ggctgccgtc ttgataaccc gcggtgcctg aaccttgaag
     1681 tgatcaagga caaacttagt ctcatcgttc ggttcgccta atgctaccgc ctcaacatcc
     1741 gtgttgcctg cctgtttctg aaattctgcc cagctcatgg cactcgtaat cgcgtcggtg
     1801 tccgggttct gatgcccaaa aatcaaagtc gtcatcttat ctgatcgctc ctcaactgaa
     1861 tagtttactt atcaagttta acacggtttt cactgacccg cgacaagtaa tctttttcct
     1921 tcagataatc gtcaaaggtc tggaagaagt tcgagatccg cggaatgtca gctttctctt
     1981 tgcgataaac aaaagaaatc tcaaagcgaa tggccggatc aaacgcaata gcataggcct
     2041 tgatttgatc agcgcgtgcc cgaacaaaac tggttggtaa ggccgtgttg acccctgaca
     2101 agttaacgaa ttgggttaac tgatatggcg tggtgaaatg tgcgaccacg tgcgggaaat
     2161 caaccatttg attcttgtac gcctcacgca gaagctgtcc aaggaaatag tcgtcaggat
     2221 aagttgccca aggttcagct aaagtatctt tgaaatggat tcgcttacgg ttagccaagg
     2281 cgtcatcgtg gtgcaagaac agcaattgtt catcaataat tttcttgctg gcgtatggtt
     2341 tccagttctt aatggtctca tctggcagat tcatgatagc caaatcaatc tggttgtttt
     2401 ccaatgattc ccaaatttcg tgacgggtca tcatccgtag cgttacttca acttcaggat
     2461 tcagttgata gtaatgagca atgaacgcaa taaaggcgct atcctcaatt gagcttaata
     2521 acccaatatt gatttttccg acggttgcac tggttgtttg ttgaatttcg tcggttgtct
     2581 ggttcaagat ctcgtagatc tcatgggttg actttaacat ggtctgacca gcgtcagata
     2641 aatgcagttt cttcccgaca gaataaaaca gcggtgcccc caccgtccgt tccaatttct
     2701 tgatctgctg tgttaaggct ggctgggtaa tgccaagcaa ttgggcggct tgggtgtagt
     2761 tcatggtttc tgccaattgc agaaaataag ttagtgtctt tgaggaaaaa atgcgctctt
     2821 gtttcgtttt catagggcgg cttccctttc gtttataatt taataatatc gttcaaccat
     2881 catcataagt ggcaatgaaa aaaaacgcaa cgaatttgcc gcgtttttaa tcgttacgtt
     2941 aagttctagc taaaaattca gttgctcgca actggtttcg gacgccagct ttgccatccg
     3001 gtataatcct taacgtgcag cagattctct gcattcttaa cgcgatcggc agacggcggt
     3061 tcgatgcctt caagcgggta cgtaatgcca agctcgtgat actttttaac gcctaacgtg
     3121 tgatacggca gaatctcaac tttttggacc acgtttttgt ccaatgtcgc aatatagtcc
     3181 cctaaccgtt tgagataagg gtcaaagtca gtgcgttccg ggaccagaac gtggcgaatc
     3241 cacatgtcat caccatgcgc cgacatatac tgcaccatat ccaaaatatt ctcattagga
     3301 aaaccggtga gctttttatg ctcggccgaa tcaatgtgtt taatatcaac taatgagatg
     3361 tcagtaacag ccatcagctt ttcaaactgg ccaaaccacg gttggtcacg cgtgaagggg
     3421 ccacctgacg tatcgaggca agtcgaaatt cccagtgcct tagccttggt gaagagttcg
     3481 agaatgaaat cgatttgtac caaactctca ccgccactgc aggtaatacc cccttggtca
     3541 ccccagaatg ctttatagcg ctgggcatcc gccaaaattt gatcggccgt catttcttca
     3601 ccaaccccaa tgttccaggt gtcagggttg tgacaatact ggcaacgcat gcgacaccct
     3661 tgcataaaga caacgaagcg aataccaggg ccatcgaccg aaccaaaact ttcgaccgag
     3721 tgaacatacc ctttgatcgg gccatcatga tcctgaccaa cttgttctaa gatatttaat
     3781 gggctttgtg actgatcgat gagtttcatc ttattgcctc cactacaaca tcatgtgtcg
     3841 ttttcaattg attttcattt cattctgcca aaaaacggca acagcatcgt tgccgtcttt
     3901 tggcaaaaca ggaatggctt cctgtcttga gttaagctgc ttacatttct tcgaagaagg
     3961 tccgagcaat gacatcgtct tgttgttcct tggtcaaatc tgcgaagtag acgcagtagc
     4021 cagaaacccg aacggtcaat gttgggtatt cttctgggtg cttctgagca tcaatcagag
     4081 tctccttatt gaagacgttg atgttcaaat gcatgccgct gttttccata tagccgtcaa
     4141 ccatgtgaac caaggtatcc ttacgagttt catcatcgtg gcccagtgtg ttcggagtaa
     4201 ccccaaacgt attactaatg ccgtcagttg cgtaatgata cggaatcttg gcggtggaca
     4261 tcagggatgc cagtgcgccg ttcttttctg cgccatatgc cgggttggca cctggtgaga
     4321 atggttcgcc tttttgacga ccgtttggtg ttgtccctgt attcttgcca taaaccacgt
     4381 tggaggtaat ggtcaggaca ctggtgctca acttcgcgcc gcgatacaga tgatgcgtgt
     4441 tcatcttgtt atagaaggtc ttaaccaacc acttagcgat gtcatcagcg cgatcatcgt
     4501 tgttaccata acgtggatag tcatcattgt cagcaacgaa gtcaactgca acaccgtttt
     4561 catcgcgaat tgccttgaca tgaccatact tgattgcact gatggaatca accgcgtgtg
     4621 acaggccgga aatcccggtt gcgaaggtcc ggttcagttg ggtatccttc aatgccagct
     4681 gtgcagcttc ataataatac ttgtcatgca tatagtgaat cacattcaaa gcattgacat
     4741 acgtgtcggc cagccagtcc atcatcttgt cgaacttatt catgaattct ttgtaatcaa
     4801 tgtaatcgct ggtgatcggt gcatattcag gccctacttg cgcttcctga atttcatctt
     4861 tcccaccgtt gatcgcatac agaactgtct tagctaagtt agcacgggca ccaaagtatt
     4921 gaacgccatc agcaattggt tgtgctgaga cacagcaagc aataccgtag taatcggtac
     4981 cccattcgtt gcgcatcaga tcatcatttt catattgaat ggttgaactt tggatggata
     5041 cttcggttgc atagcgtttg aatccttctg gcaagcgttc gctccaaagc aaggtgatgt
     5101 ttggttctgg tgctgcgccc atgttgtcca aagtcttcag gaaacggaaa gccgtcttgg
     5161 taacgtggtg acggccatca ttgcccattc ctgccaatga caaggttgcc cagattggat
     5221 cgcctgagaa cagtgagtta tattcttcag tccggatgaa acgaaccatc cgcaatttca
     5281 taaccaaatg atcaatcagt tcctgtgcct gttcttcgtt caacttgcct aagcgcatat
     5341 cgcgttggat ataagcatca ataaccgtat cgatccggcc aacggacatt gcggcaccgt
     5401 tttgagtctt aacagcagcc agatagccaa agtagatcca ctgaacagct tcttgcgcat
     5461 tagctgcagg acgcgagatg tcatagccat attccttggc catcttcttc atgtcgttta
     5521 aggcacgata ttgttcattg atttcttcac gcagtttgat cacatcgtca gtcatttcgc
     5581 cgtcgccagt caagttataa tccttgaact tctcggccat caaacgatcg atcccgtaaa
     5641 cagcgatccg tgggaaatca gaaacaatcc ggccacggcc gtatgcgtct ggcaagccag
     5701 tcacgatctt gtaatggcga gcctttcgca tatcaggggt ataagcatca aagacacctt
     5761 gattatgggt cttacgatat tcattgaaaa tcttgtgttc ttgaggatct gtcttgaagc
     5821 cataagattc caatgcatct tcagccattc gaataccgcc aaatggcatg aatgctcgtt
     5881 tgaatggctt gtcggtctga acaccaacaa tcttttcaag atctttgttc aaataaccag
     5941 ggccgtgtga ggtgatcgta gatggaatat tgttgtcagc atccaaaaca ccgccatttg
     6001 cacgttcttg cttctttaaa tttagaacct gattgttcag gactgttgtc gcttcagtgg
     6061 ggccagcaag gaaactttcg tccccgtcat attggttcag gttatgctcg ataaaatcgc
     6121 gcacattaat ttcttcttgc cagtcgccgc cgttaaagcc ttcccaataa ttaggaactt
     6181 tggtttcgtc aagctgtttc atagttgttt gcctcctaaa gtggattaca gatgtgacag
     6241 ttcttacaaa cacagtataa cacgccgcca aatctatgca agcgttttat tgcccatata
     6301 ataggcgtta tattgttttt taagtgtgct tcgtcgcttc ttttcgccca tgatttcgac
     6361 attttgttaa gttgtgcaca actgatctgt cctataataa tcaaaaacgc cgccatctgt
     6421 attagtacag acggcggcgt caatgatcac catttattcg acttgatctg ctggttcttc
     6481 tttggtttga acaaaaactg gcttgccaag gacatcagtg tcaatgacaa acgaaccatt
     6541 cgaatagcgg tcacctgctg gatgttgtgc cggattaagg gtcgttacct tacccgtatc
     6601 ggtcaaaaca ttcaggcggg tagcgtcatc gactgacatc atcgcgacaa tccgatgcgg
     6661 atcacgctta agctcacgca agaccagtaa accacgacgg gcacgactca tttccccgac
     6721 ctcgcttaat gccatctttt tgaaggcgcc acgttgggtc aaaataccga ccttagccgt
     6781 agttggatcc ttcactagaa tgaaattgac aacctcatcg tctggcttta gatccatact
     6841 tttaacgccg gttgcccggg caccgacagt tgacacatcg tttaacggga atgtcagtcc
     6901 gtaagcgtgg cggctgacca caaagacatc ctgttgctga tcagtcgtga agtatgcatt
     6961 ggtgacaatc gcggctgggt ctttcagctt catcgccatc atcggcttac tcttgtacgt
     7021 ccgttgcggc tgcaaatcac ttaaggcagt ttgtttgatg tacccgtcac ttgaccctaa
     7081 cacaaaactg ccagcgccat cgagttgatc aaaagcaaac actgccaaga ctttttcgtc
     7141 agtgccaagg ccaactgttt ggcttaagtg ttcgccggtg tctttccaac gcgcatcact
     7201 aatttcatgc actggtcgat aaatgacatt tccggcattt gtcacgatgt aaagatgctg
     7261 caacgtactc agttcgccag tgaaaatggc aagatcattg gccttcaaac cattgtcggc
     7321 cggatcaacc gcctgataac tgcgcagtga actgcgttta acgtacccat cacgagaaac
     7381 ctgcaccata acggtttcat cagccaccgt caccgttgtc gccacttcaa gcgtttcaat
     7441 tttggcttga atgctgctgc gacgatcatc cccgtactcc ttggcaatcc gcttcaactc
     7501 gccttcaatc acccgatcgc gggcagcggg gcgggccaaa atatcttgat actcggcgat
     7561 tgctttcgcc aattgtgctg cttctttctg taaagccgtg atatcggtat tggtcaatcg
     7621 atacagctgc aaggaaacaa tcgcttccgc ctgagcttcc gaaaaatcaa acttcttgac
     7681 taagttacgc ttagcatccc ctttatcctt ggaagcacga atcgcggcga tgacctgatc
     7741 caaaatcgat agcattttga tcaagccttc gacaatgtgc tgtcgagcag cggccttgtt
     7801 gaggtcaaaa cgcgttcgcc gagtgaccac atcgcgtcga tgttcgacgt atgcttccaa
     7861 catggcctta agtcctagca acttcggctg catgtcggca atagcgacca tgttaaagtt
     7921 gtatgcaatt tgtagatcgg tatttttaaa taaatagttt aagatgccat gtgcatcggc
     7981 ttcttttttt aattcgatga caacgctaag cccaaaacgg tcgctttcgt cacggacttc
     8041 ggcgataccg tccacttttt tgttgatgcg taattcatcg atttttttaa tcatctgcgc
     8101 tttattgaca tcatacggga tctcagtgac cacgatcttc tcacgaccgc cacgaatggt
     8161 ttcgatgtgt gtccgagaac gaaccacgat tttaccgcgg ccggtttcgt aagcttgctt
     8221 gatgccatca agcccttgaa taatcccacc tgttggaaaa tcgggaccct tgacgtattg
     8281 cattaaagta tctaaatcag cagtgggatg cttcagcaag tataagacgg cagcaataac
     8341 ttcccgcaga ttgtgcggcg gaatttcggt tgcataaccg gcagaaatac cggtggcacc
     8401 gttcaccagc aaatttggaa acccagctgg cagcacagtc ggttcctgtg ccgtgtcatc
     8461 aaagttcaac accatatcga cggtttcctt atcgatgtcg gccagcattt ccttgctgat
     8521 tttgcttaaa cgcgcttccg tgtatcgcat tgcagctggc ggatcaccat ccatggaacc
     8581 gttattcccg tgcatctgaa tcagtggggc ccgtaacttc caatcctggc ttagccgaac
     8641 catcgcttca taaatggagc tgtcgccgtg gggatgataa ttacccatga cattcccgac
     8701 acttttagcc gacttgcgga agcccttatc atacgtattg ccatcttggt tcatcgcaaa
     8761 taaaatgcga cgctgaaccg gtttgaggcc gtcacgcaca tcaggcagcg cccgttcttg
     8821 aataatgtat ttcgagtacc ggccaaaccg gtcgcccatg acctcttcta aggtcagttc
     8881 ttgaatctga ttggccaatg gcttttactt tcctttcttg tccagttgtt tgacgatttg
     8941 cttggcacca aactgtaatt tttcgtgatt agcagtcggg gtttccaaaa tactgccgtc
     9001 gtcatccata tcaaacttga cgttatgctc aatccattca cgacgcggct caacgcgatc
     9061 acccatcaaa gtggtcacgc gtcgttccgc cagctgagca tcgtcaatcc gaacccggat
     9121 caaagtccgc gtctcaggat tcatagtcgt ttcccaaagc tggtcggcat tcatttcccc
     9181 aagtccttta aatcgggtca atgtgtaacc cttgcccatg gccttggtct ctttggccaa
     9241 ctcttcatcg gtccaagcat aactgatctt ggttttagca ccagcgcctt tttgcagccg
     9301 gtacaatggt ggcaaagcaa tgtaaattcg gcctgcgtca atcagcggcc gcatgtagcg
     9361 ataaaagaag gttagtagca aaatctgaat atgcgcgcca tcagtatccg catcagtcat
     9421 aataatgatt ttgtcgtagt tggcctgctg cagatcaaaa tccgcaccga caccagcgcc
     9481 gatggtgtaa atcatcgtat tgatttcttc gtttttaacg atgtcctgta acttggcctt
     9541 ctgggtattc agtactttcc ctcgcaatgg caagatcgcc tgaaacttcc ggtctcggcc
     9601 ttgtttagct gaaccaccgg cagaatcccc ttcgacgaga tacaattcgt tacgcttagg
     9661 gttcttggtt tgcgccgggg tcaatttacc ggaaagcaaa ccttggtcct tcttgcgctt
     9721 gcgtcccgtc cggctatcat cgcgtgcttt tcgagccgct tcccgcgcat cacgggcttt
     9781 gacggcttta cgaaccaact cttgcgactc ttcaccgttt tccatcaaaa aagttgacag
     9841 cttgtcatag acaatcccat cgaccacagt gcgggcttgc ggcgtaccaa gcttgccctt
     9901 tgtctggccc tcaaattgca aaatttcttc tggaatgcgg acacttaaaa tacctgcaaa
     9961 accttcacgc acatcactgc cttcaaggtt cttgtcgcgt tccttcagca agccgacttt
    10021 tcgggcaaac tcattgaatg cacgggtcat gccgctgcgc aagccaattt catgcgtccc
    10081 gccatcacca gtgcgaacgt tattaacaaa cgaaatcagg ttttcagaat agccatcgtt
    10141 atattggccg gcaaaatcaa ccacgatacc gtcctttttg ccttcaaaat tgatcacctg
    10201 tgacaatgcg tctttgcctt cattaaggta tttaacaaaa ctgaccaagc catcaggata
    10261 gtgataactg tcatgcttgc cggtgcgttc atccgtcaga ttaatcgtaa tatttttcag
    10321 tagaaaggct gattcgcgca agcgttcggc caaggtatca taactgaaga cggtggtttg
    10381 aaaaatagtc gggtccggct tgaacgtgat ggtcgtgcca ttaggttcat taactttgcc
    10441 caacttctgc aaactgccat caggatgacc gccattgata aaatgctcct caaatgcgtg
    10501 cttatcccgc acaactcgca cagtcaatga ctccgataag gcattgacga cgcttgagcc
    10561 aaccccatgc aaaccaccag aagttttgta actattttgg ttaaactttc cgccggcatg
    10621 tagcacggtt aaaatgactt caatcgtcgg tttgccactc gggtgcatcc ccgttggcat
    10681 cccgcgacca tgatcctgta cggtcacaga gttatcggcg tgaatcgtca cattgatctc
    10741 atccccaaac cccgcgagcg cttcatcgac agagttgtcc acgatttcat agaccaagtg
    10801 atgcaaaccg cggccatcgg tggatccaat atacatcccc ggacgcttcc gcacagcttc
    10861 caagccatgc agcacctgaa tggatgaatc attatatgct tgcgttgctt tatccatagt
    10921 aaactccctt ttttgaacaa ctaagttata gaatacacca cgcgttgaga tttcagaaat
    10981 aaaaaataag agcgcgagcc atcccgatta gaaaccggag cataagcggc cttgggtgcg
    11041 atggttgggc tttgaccatt gtgcccaagg tccttatgtg caggtttctg ggctggtgaa
    11101 cgcgtttcag tagagcgcga gcaggggcgg ttagcaaccg gagtgtaagc ggccttggac
    11161 gtgatggttg ggctttgacc attgtgccca aggtccttac acgcaggttt ctgggctggt
    11221 gagcgcgttt aggcatcaac accatcaaca gcagacctca ccgtattgct ctcagaactc
    11281 ctgttttctc ctcaaaatcg acccagccgg ctaataccat cattgttcat ttaaatttta
    11341 ttagccgtgt caatgtccca aagctcagca gaaaaccgca cttccctaag catggcacat
    11401 aactatgact tcttgacgtg aaattcatcg cccgctggca ccatatctac gctgtgcccc
    11461 gccatgatcc ttgcacaaaa cggcaccaaa tcgcgccaca acccgcttca caggttttat
    11521 tcgaatgtac gttcgtttta ttctactgac gtatcactca aaagtcaaaa atgctaaaat
    11581 agtttctagt ttgagaggag gggcacattt gatacttgtg ctttgtttta tactcgcgta
    11641 tttcataggc gccatcccgt ttggtgtggt cattggtaaa ctcttttatc acacggatat
    11701 ccgcaaaggc gggagtcaca atattggcac cacaaatgct tatcgcatgt tagggccagt
    11761 cggcggctca attgtcttgg tgctggatat cttaaaaggc acgttggctg ccagcttacc
    11821 cattctcttt ggcatcgagc atcattggct ggtgctgatc gtgggtttag cggccgtatt
    11881 cggtcataca ttttcaatct acattcgctt taaaggcggt aaggcggtgg caactagcgc
    11941 tggcatttta cttgcatata atccgccatt ttttgtcatt gcatttgcca tctggtttag
    12001 tttgatcttg ctaacgtcca tggtcagcgt tgccagcaca ctgggtatgg tgttgatcac
    12061 agcttggtcg cttgtttacc atgattggtt gctgacaact gttgcctgcg ggttgctggt
    12121 tgtctttttg atcaaacatc gggcaaactt caaacgcatc aaggccggag atgaaaatat
    12181 ggtgcccttt ggcctaggcc aatatcttcg tcaacaccgg ggccgctcat agtcaccttt
    12241 tgatggcaac caaaaagaca tccgaaactg gatgtctttt tttcatgtac ttaatcgaca
    12301 aactgatgac accttagaaa atgctgatca tgtaaccctt ctcaaatgcc gtgccaggtt
    12361 caagtcgatt gatcccgagt ttgcgcgtca ggtcgccagt gctgccaatc gtgtcggcga
    12421 tgccccacca aggttcgatg cagacaaagt cgccagtggt tggatacgga ctccaaacgc
    12481 ccagatatgg ggtatcggtc atggtaacgc tgacaccatg tttcgtcttg tcagaaacca
    12541 agttgaaggt tgtcttacca agcaacgcga aaattaaagc atcatgatca aatgtttcgt
    12601 gcgttaaggc caaattggca tcagttgcag ccaaggtccg gtgcgtgtaa tcaatgcctt
    12661 caccagcaac caacggaatc tgaacaagcg acttacgcgg tttgaagttc aaataataat
    12721 cggagaattg agtatccggc gtcattggga ccttgaagcc cggatggccg ccgatgctaa
    12781 agaacagtgg ctcacttttg tccggattgt caacgtgata cgtgacatgt agattgttat
    12841 tttctagtgc aaacgtgatg attaaacgaa aagcgaacgg gtacatcgcc cgcgttttgt
    12901 catcatcctt cagaacgaag ctcgctttaa acggtgtcgc agagagcacc gtgaaatcac
    12961 gatcacgggc aaaaccgtgc tggcccatgt ggtaagtctt gcctgcgtaa tgatattgat
    13021 tgtcagccag cgccccaaca atcgggaaca agaccggggc gtggcgaccc cacaccgcag
    13081 gatctgcttg ccacagacgc tccctgcctg tcaggttatc tttgatactg gtcagttcag
    13141 caccatgccg actgatttta actgtcaaaa agtcatttgc aatcgttacc atacatcctc
    13201 atcctttacc tacaacatta ttgttaacta caaaatatac cgcgtcatgt ttgaatcagc
    13261 cgcaatatgg ccaatcttgt catccacata ttgctgggtg acggtcacag cgcccatcgc
    13321 catatctgga ccttcataaa gtacgtcttc aagcagtttt tcaagaatgg tcgccagtcg
    13381 ccgcgctcca atattatcag tgtcgtgatt gacctgagtc gcaatctctg caattcgatc
    13441 aaccgcttcc ttcgtgaagg taatcttcac gccatctgca ccaatcaagg cgatatactg
    13501 cttgatcaaa gcattgtctg gctcggtcaa gatccgcaca aagtcttttt cggttaagtc
    13561 cttcaattca acccgaattg gaaaacgccc ttgaagttca gcaatcaaat cactaggctt
    13621 agcctcggca aacgcacctg agccaatgaa caagatgtga tccgtattga taggaccata
    13681 cttagtgtta atctgcgatc cttctacaat cggtaaaata tctcgctgca caccttcacg
    13741 cgaaacttca ccgctattat gcttgtttcc cgcagcaatt ttatcgattt cgtcgatgaa
    13801 aatgatcccg ttattctcgg cactttgaat ggcgtcgtga taaatgtcgg catgattgac
    13861 cagtttgtca gattcctctt tgatgaagat ttcgcgagct tctttgacgg tcatggtccg
    13921 ctcaaccttt ttcttaggca ttaaagcgcc aatggtgtcg cttagatcaa tgcccatctg
    13981 accgtacatg tcacccatgc caccgccttt tttctcatca ttgacagcaa cggtgatttc
    14041 atgatcttca agtaatcctt tttccagttg ctttgccacg ctcaaacgct tattgcgaat
    14101 atcatcggtc acttcgccgc ctgcgtctgc atcatcgcca gctggcattt tgccattttg
    14161 catcccttgc aacatgctca tcatctcggc catcggattg gtattctttt ccttacgaat
    14221 ggccggcact aaaattttaa ccaaacgctt gttggcttct ttttcggcac gtatgcgaac
    14281 ctttgaaaat tgcttctctt cttccatggc aacggcagtt tcggcaagat ctcgaaccat
    14341 ggattcgacg tcacggccaa cgtagccaac ttccgtaaac ttagtcgctt ccaccttcac
    14401 aaatggcgcc tcaactattt ttgccagtcg tcgtgcaatt tcggttttcc cgacaccagt
    14461 tggtccgatc atcagtaagt ttttcggggt aatctcttct tgcatttttg gcgataattg
    14521 cattcgccga taacggttat acaaggcaac cgcgacggcc cgttttgcat catcttgtcc
    14581 aatgacatat tgatcgagtt tttcaacgat ctgttttggg gtttgtactt ctgccatcat
    14641 aagcctcctg taggtcaatg taattgccaa cggttacaaa ctaaaagctt tcgacaataa
    14701 cattgtggtt tgtgaaaata tcgatattcc ctgcgatatt cactgcttct ttggcaatgt
    14761 cagctggtgt catatctggg gcatgccgca gcatcgcgat tgccgcggct tgcgcaaagt
    14821 tgccgccgga gccgatcgct accacgtctt catctggatc tatcacttcg ccagacccgg
    14881 atacgagtaa caggtcatgc tcatccatca cgatcatcat ggcctcaagt ttctgcaagg
    14941 tcggatcctt gcgccaatct tgagccagcg caactgcgga acgtcgcaag ttgcccgcat
    15001 aatgctccag cttcttttca aaccagtctt gcagggtgaa agcatctgcc accccgccgg
    15061 caaacccgat gacgacttga tcatgataga tccggcgaac tttctgcgcg ttgcctttca
    15121 tgatgacctt ttcgccaagg gttacctgac cgtcaccggc caaagcggtc acaccatctt
    15181 ttcttactgc tgcaattgtt gtcatagtca tgctcctttt taagtgagcg cgagcagaag
    15241 cgcttagaaa ccggagcata agtgggctgg aagcctaaat ggctgaattt tggctattta
    15301 ggcttgcagg tcattatgtg taggtttctg cgactgcgag cgcgttatct gcgtatctcg
    15361 tcggataaaa acagctaaag tagcgattaa tctgttatcg ccaatgttct tagcttaaaa
    15421 aactcagact gcttttgcat catgctttag tcttaattat gcttcggata atatttcata
    15481 tactcatttt ttaaatgtgc catggtgaca tgcgtgtaga tttgtgtagt tgataaactt
    15541 gcatgaccca gtagctcttg aacagttcgc aggtcagcac catgatccag catatgggtt
    15601 gcaaaactat gccgcagcat gtggggatga atgttagctg tcagcgtcgt ctgcttgatg
    15661 agctgatcca aaatatattc aatgccacgc gaggtaatcg gacgcccata ctggttcacg
    15721 aatacatatc gatgctgtgc ctgactttta gccatcaaga cttgtcggcc atcttttaaa
    15781 taagttcgta gtgcttgctg agcgtactgt ccaaagggca catacctatc tttgttgcct
    15841 ttaccatgaa tcaacagtaa tgccgtattg aaatcgacct gattcaatgt cagtttggca
    15901 cactcggaaa ctcgaatacc ggtgccatac aaaacttcca acaaagcgcg attacgttga
    15961 tccagcgggg ttttgccagc aactgtcttg aacagttcct gaatctcggc ttcatagaaa
    16021 aattgtggta aatgatgatg ctgctttttt aattcaacca gctcaaatgg gttgcgtttg
    16081 acgacatcaa ttcgtgtcaa ataacggtaa aagcttcgca aactactgat ttttcgggca
    16141 atcgatgtcc gtgccaaatc ctgtttgtta agatcagtca aataagtttg aacgtctaaa
    16201 tc
//
