LOCUS       gnlProkkaELPIFMBE_1    12732 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ELPIFMBE_1.
ACCESSION   gnlProkkaELPIFMBE_1
VERSION     gnlProkkaELPIFMBE_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 17:26:12
            Original ID  :: gnl|Prokka|ELPIFMBE_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 4156907
            Orig. end    :: 4169639
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12732
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7732]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7732
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12732
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12732
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="13"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             47..1432
                     /gene_functions="transport (smcogs) SMCOG1169:sugar
                     transport protein (Score: 441.1; E-value: 6.8e-134)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_4196"
                     /transl_table=11
                     /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTLT
                     EGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIASR
                     VILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFEAWR
                     WMVGLAAVPAVLLLIGIAFMPESPRWLVKRGREEEARRIMNITHDPKDIEMELAEMKQG
                     EAEKKETTLSVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGTSASAL
                     GTMGIGVLNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLSASTAWM
                     TVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVSLVFPLML
                     SAMGIAWVFMVFSVICLLSFFFAFYMVPETKGRSLEEIEASLKNRFKKKKSTQNQMLNE
                     RTL"
     CDS             complement(1474..3354)
                     /locus_tag="ctg1_4197"
                     /transl_table=11
                     /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYY
                     KALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAFKK
                     ENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPCEKD
                     SVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENE
                     FEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNA
                     ILFIPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSEDLSLNIS
                     REMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANK
                     DQLKDLLLFYSSKEKKLVSLDEYVSRMPEKQKYIYYATGDSYDRIEKLPQTEMVADKGY
                     EILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESKYKDLFEEMK
                     NILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAEKVLEINPNHE
                     VFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKVMV"
     CDS             complement(3522..3773)
                     /locus_tag="ctg1_4198"
                     /transl_table=11
                     /translation="MKVQHKKELKFYCIVTISSAFVVLTVISFLLQEITFPVTASAFLN
                     ASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG"
     CDS             3890..4699
                     /NRPS_PKS="Domain: PKS_KR (7-160). E-value: 2.5e-09. Score:
                     29.1. Matches aSDomain: nrpspksdomains_ctg1_4199_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     247.6; E-value: 2.2e-75)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_4199"
                     /sec_met_domain="adh_short (E-value: 1.3e-31, bitscore:
                     107.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 6.7e-36, bitscore:
                     122.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQMEE
                     TVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHEYP
                     VDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKGGIT
                     NLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEKFREANKWVTPLGRLG
                     QPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIDEKWK"
     aSDomain        3911..4369
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_4199_PKS_KR.1"
                     /evalue="2.50E-09"
                     /label="ctg1_4199_PKS_KR.1"
                     /locus_tag="ctg1_4199"
                     /protein_end="160"
                     /protein_start="7"
                     /score="29.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TAVITGAATGIGQATAEVFANEGARVIIGDINKDQMEETVDAIRK
                     NGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHEYPVDLFDRI
                     IAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG"
     CDS_motif       3917..3994
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_4199_0001"
                     /evalue="1.80E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg1_4199"
                     /protein_end="35"
                     /protein_start="9"
                     /score="17.4"
                     /tool="antismash"
                     /translation="VITGAATGIGQATAEVFANEGARVII"
     CDS             5001..5198
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4200"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3.1e-13,
                     bitscore: 47.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKELSNLELEKVEGGNWQNVTKNTLFAAADGAAIGGMFGGPAGAF
                     VGAHYGAAAYAIGYALDHRK"
     CDS             5222..5467
                     /locus_tag="ctg1_4201"
                     /transl_table=11
                     /translation="MNNLENKSFEVLSDNQLELVEGGSGYGDGVAGGLTGGAILGGVVK
                     GAQNGAKYGRLGGAWGVAAGVVVGGAIGGYLGYKGA"
     CDS             5549..7732
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 289.2; E-value:
                     1.1e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4202"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.1e-44, bitscore:
                     149.5, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 4.3e-237, bitscore:
                     787.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFFKKYQYVKQIDEKDCGAACLATILKHYGSKLSINKIRDIAGTD
                     KQGTSALGLVRAAEQLGFSAKGVKADKTALEEPFTLPAIAHIILNGQLLHYVVIHKITK
                     DQIIIADPGRGIIKYTKKEFLEVWTGILILLTPSETYKIHVETSTIRSDIFKLILHQKS
                     LIIHTILASFIITVFGIMGTFYFQTVIDEILPNRLNSTLHILSFGLIIMYLFKVLLTAF
                     RQYLMILLGQKLSISIMFGYFKHVLSLPMKFFSTRKIGEIISRFNDASKVIDAIISASL
                     SVVLDTVMLVMVGIFLYLQNTTLFLITLAFIPFYVLTVWFFMKPYESINNTEMENNAQL
                     TSKIVETLNGIETIKAYNAEYMMSYETEKRFVKYLRSAFKHGVIDNLQNSIKMFLDLAS
                     GAFILWIGSTQVMKGTLSIGQLITYNALLTYFLNPLQNIIGLQSKLQSASVASKRLGEI
                     LEVEHEIKDKDAQITTPGSINGPIEFIKINFRYGTRRLILKDITLRIDKGEKVAFIGES
                     GSGKSTLTKLLMKFYTAESGDILINGYHINDIHAHSLRESISYIPQESHFIQGSIFENL
                     LLGNSGSFTFEEIIEVCKQTNVHDFVNDLPMRYDTLVEENGSNLSGGQKQRLAIARALL
                     RKPNILIMDESTSNLDTTTEQGISKMIYDQTVGITTIIIAHRLSTIMNCDKIFVMENGE
                     IIEYGNHNDLLKKKGKYYELWENQMPSRGMVTI"
     CDS             7733..9202
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 53.6; E-value:
                     2.8e-16)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_4203"
                     /transl_table=11
                     /translation="MKRNFFNLHDLKDSREFYESKPKPIGVFFTYILIALLIACIVFSF
                     YGKKEVILKTTADIQYTKPNSNVTNEVAGKVKTVDIKQVDKVKKGDTLLTLDNTEIQAQ
                     KKAVKADIKDLKEQAALNKTLKKSIENDKNLFSEDDHWGYQDQYLSYEKQSILLESSKE
                     NAKTQQKKLKKQKESIKDSLDKTKNKVKLKLQRISDLQDSIKNNKSFAKQDDKYSSYYN
                     SYQTNKQNVEQQFDDLRKMKDELDKNRFSQQKENLNGQLESLKQDMLVKLSEEKDELNQ
                     SLDEINSSIKSDDSDSDSDNSEETNYKLSIEQLKTNLLNQTSQKQTDLQTTLKSKEDDL
                     KMIDLQLEKYKIKAASDGYVNVLTNISPGDNLQAGTAILTIIPDKEKLKANIYIPSHEI
                     TNINEKDEVRFHIENTNQTIKGVITKISPDSISDQNGQKFYIAESTIEKNKVMNDNGST
                     LHLKNGMQTDVSIIVDSKRYIDSLLEILHLQ"
     CDS             complement(9720..10862)
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 40; E-value: 9.3e-12)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_4204"
                     /transl_table=11
                     /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLYY
                     EDKFSIIEDLIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSVMM
                     NRGHFHRFFRDVFQQDVLLTPVHVNLTPIEREIYGHYRALYTYAIILYWLNEDAAATPE
                     AISQKVWELVSQKRFYWLFGQAVPGEREKDKQIDRRVVRTREALQKAFLDVLAEKKDYA
                     AITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCEVIIDHLTIASSPNEFSLKEAE
                     KALASLLSALSKMPIVYFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKLYAHYVS
                     AMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL"
     CDS             11005..12342
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017:aldehyde dehydrogenase (Score: 304.2; E-value:
                     2.1e-92)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_4205"
                     /sec_met_domain="Aldedh (E-value: 3.6e-100, bitscore:
                     333.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIAH
                     EEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANGIL
                     MYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRDAFD
                     EKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGKSPTI
                     IDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGFMEDDH
                     NPDRSKFTQIVNDRNFNRVKDLFDDAIEKGAEVVFGGVFDASDRTISPTVLKNVTPDMK
                     IMQEEIFAPILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHTTSGNAAI
                     NDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQASK"
ORIGIN
        1 atatttttag atactcattg gctcaacaac tgaggaggag acatttgtga agaaagacac
       61 aaggaaatat atgatctact ttttcggcgc tttaggggga ctgctatatg gttacgatac
      121 aggcgttatc tcaggagcac tcctgtttat caataacgat attcctttaa cgacattgac
      181 agaaggattg gttgtcagca tgctgctcct tggcgcgatt ttcggttctg ccttgagcgg
      241 cacatgctca gaccgctggg gcaggagaaa ggttgtattt gtcctttcca tcatttttat
      301 tatcggtgcg ctcgcttgcg cgttttctca aacaatcggc atgctgattg catctagggt
      361 gattctcgga ttggccgtcg gcggttcaac ggcactagtg cccgtgtatc tttccgaaat
      421 ggcaccgacg aaaattcgcg ggacactcgg cacaatgaac aacttaatga ttgtcacagg
      481 aattttgctc gcctatattg tgaactacct gttcacaccg tttgaagcgt ggcgctggat
      541 ggtcggtctg gccgcagtgc ctgccgtgct tctattaatc ggcatcgcgt tcatgccaga
      601 atcgccaaga tggctcgtga agcgcggccg tgaagaagaa gcgagacgaa tcatgaacat
      661 cactcatgat ccaaaagaca tcgaaatgga attggcagag atgaagcaag gagaagcaga
      721 gaaaaaagaa acgacactca gcgtcctaaa agccaaatgg attcgcccca tgcttctgat
      781 tggcgtcggc ctagctattt tccagcaggc tgtcggcatt aacacggtca tctactacgc
      841 gccgaccatt tttacgaagg ccggtcttgg cacgtcagct tccgcactcg gcacaatggg
      901 aatcggcgtc cttaacgtca tcatgtgtat cactgccatg atcttaattg accgtgtcgg
      961 acgcaaaaaa cttctgatct ggggaagtgt cggcatcaca ctgagccttg ctgctttatc
     1021 aggcgtgctc ctgacactgg ggctttccgc atcaacagcg tggatgacag tagtctttct
     1081 cggcgtctat atcgtctttt accaggcgac atggggtcct gtagtatggg tgctcatgcc
     1141 tgagctcttc ccgtccaaag cgcgcggagc cgcgacaggg ttcacgactt tggtgttatc
     1201 ggcagccaac ctgatcgtgt cgctcgtctt cccgctgatg ctaagcgcaa tgggcatcgc
     1261 atgggtcttt atggttttct cagtcatttg tcttctctca tttttcttcg ctttctacat
     1321 ggtgccggaa accaaagggc gaagcttgga ggaaattgaa gcaagcctga aaaaccggtt
     1381 taaaaagaag aaaagcaccc aaaaccaaat gctgaatgag cgtacattat aaaaaaagga
     1441 atcgtctcct tatgggacga ttcctttttc tgtttacacc atgaccttgc aaatattgtt
     1501 cgtaaattcc acagggtcct gaatcggcag gccttcgatg agaagcgcct gattgtacag
     1561 aaggtttgtg tacaggctca gcttctcttt atcttgttca aacgcgtcct gcagcgtttg
     1621 gaatacctcg tgatttgggt tgatttccaa cactttttcc gccttcacat tttggctgtc
     1681 aggcatcgcg tttaagattt tttccatctc aattgtcact tcgccgtcag cagcaaggca
     1741 gactggatgt gatttaagcc gttttgagat tctgacgttt ttcactttgt ctgacagaat
     1801 gtttttcatt tcctcaaaca gatccttata cttgctttcc tcttcctcgg actgcttttg
     1861 atcctcatcc gtgtctatgc caaggtctcc gcttgatacg gacttgaatt ctttttcctg
     1921 ataagaagcc agcattttaa ttgcaaactc atcgatgtcc tcagtaaagt agaggatttc
     1981 atagcctttg tccgccacca tttccgtttg cggcagtttc tcaatgcggt cgtaagaatc
     2041 accggtcgcg taataaatgt atttctgctt ctctggcatt ctggaaacat actcgtctaa
     2101 gctgaccagt tttttctctt ttgaagagta gaataatagg agatccttca attgatcctt
     2161 attcgcgcca aaatcattgt acacgccgaa tttcagctgt ctgccgaacg acttgtagaa
     2221 cgtctcgtat ttctcgcggt cttttttcaa caggctttgc agctcgcttt tgattttctt
     2281 gctgatgttt ttcgcgatca gcttcagctg gcggtcatgc tgcagcattt ctctggaaat
     2341 attcagcgat agatcctcag aatcgaccat gcccttcaca aagctgaagt ggtccggtag
     2401 caggtctgcg cacttattca tgatcagcac gccattggaa tacagctcca agcctttctc
     2461 atattccttg gaatagtagt caaacggcat gttttcaggg atgaatagaa tcgcgttgta
     2521 gcgaacggct ccatccacac tgatatgaac gtgtgtgagc ggtttatcaa acccgtaatg
     2581 cttttcagca tagaattttt cataatcctc atctgtcagc tcgcttttgt tttttctcca
     2641 gatcggcacc atgctgttga ccgtctgctc ttcctgcacc tcttcaaatt cattttcgct
     2701 gccttccttc ggcttattaa ttgttgtatc cattttgatc gggtagcgaa tgaagtcgga
     2761 gtacttcttg atgatcgctt ttaaacgata ttcctctaaa aactcgtcat agctgtcatc
     2821 ttctgtgttc tctttgattt tcaggataat gtctgtaccg acagaatcct tttcacacgg
     2881 ctcaatcgta tagccgtctg cacccgcaga ctcccattta taagcctctt cgctgccaag
     2941 cgctttactg atgactgtca cgacatcggc aaccataaat gccgcgtaaa aaccaacacc
     3001 gaactgcccg ataatgtcat gtccgtcttt cagctcgttt tcctttttaa acgcgaggga
     3061 accgcttttt gcaattgttc caagatgctg ttcaagctca tcctttgtca ttccgatccc
     3121 cgtatcagag atggttaatg ttctcgcatc tttgtcagct gcgaccttta tgtagtaact
     3181 gtctttatca aacgtaagcg catcgtccgt aagcgctttg taatagattt tgtcaatcgc
     3241 atcactcgaa ttggagatta actcgcgcag gaaaatttct ttttgggtat aaatggagtt
     3301 aatcatcata tccagcaagc gtttagactc tgctttaaac tcttttttcg ccactcttga
     3361 tcgctccttt accattatgt aaaccctttt cagcatctat ttatcacata agatgacaat
     3421 tgtcaattag attgatagat gcatatatat gtaaatttaa cattagttgg atttgttttc
     3481 actctttttc tcactcattc tcataaaaaa gagaggcttc atcaccctct ctttttttct
     3541 gtgtcattcc agcggccaaa ctcccgcttc atccaaatat gcaccgggta gaaaaacaaa
     3601 ccgaacggta tcaaaaacaa aagattatgc catgaagcat tcagaaatgc gcttgcagtc
     3661 accggaaacg taatctcttg caataaaaaa gagatgacag tcagcacaac aaatgcagat
     3721 gaaatggtca cgatgcaata aaacttgagc tccttcttat gctgtacctt caaacataca
     3781 aacctcccaa caatttctaa ttcatcttaa catatgctgg cctttctttt ctcgcatgtt
     3841 tatcactgca catagcggga agacaaatag aaaaaggagg tctcgtatca tgggaagact
     3901 tgaaaacaaa acagcagtga tcacaggcgc cgcgacaggc attgggcaag cgacggcaga
     3961 ggtttttgcc aatgaaggcg cgcgtgtgat catcggagat atcaataaag atcaaatgga
     4021 agaaacagtt gacgcaataa gaaaaaacgg aggacaggcc gaatcctttc acctcgatgt
     4081 gtcagatgaa aacagtgtga aagcatttgc tgatcaaatc aaggatgcat gcggaacgat
     4141 tgatattctg tttaataatg ccggcgttga tcaggaaggc ggaaaggtgc acgaatatcc
     4201 ggttgacctg tttgaccgca ttatcgctgt cgacctgcgc ggcacattcc tttgcagcaa
     4261 atatctgatt ccgctcatgc tcgaaaatgg aggctccatc atcaacacct cctccatgtc
     4321 aggccgtgcc gcggaccttg accgctcggg ctacaacgca gcaaaaggcg gcatcaccaa
     4381 cctgacaaaa gcgatggcga tcgactacgc acggaacggc atccgcgtca attccatttc
     4441 accgggtacg atcgaaaccc cgctgattga caaattagca ggcaccaaag aacaggaaat
     4501 gggtgaaaaa ttccgcgaag ccaacaaatg ggtcacgccg ctcggccgcc tcggccagcc
     4561 gaaggaaatg gcgacagtgg ccctgttcct cgcgtcagac gacagctcat acgtcacagg
     4621 agaggacatc accgcagacg gcggcatcat ggcatataca tggcctggga agatgctgat
     4681 tgatgagaag tggaaataaa attcagatga ttcattaaga gagggtggat agaaatctgc
     4741 cctcttttat tgaatttagg attagcattt caaaaatctt atacagtaga ttattagaac
     4801 attatagtaa taatccaatt tatcctcttg aatatacatt taaagtcaag tcgtttgtcc
     4861 aaaagaaatt aaataaactc caacatcttc atcatctaaa agtaagttaa ttaccaaaga
     4921 aaaatatagt aaataatatt gattttacca ataatttata ctagaataac taggaaacca
     4981 gtacaaaagg agggttattt atgaaagaat tatctaattt agaattagaa aaagtggaag
     5041 gcggaaactg gcaaaatgtt acgaagaata ctctatttgc tgctgctgat ggagctgcaa
     5101 tcggaggaat gtttggtggt ccagcgggcg cttttgttgg ggctcattat ggagctgctg
     5161 catacgctat tggttacgct ttggatcaca gaaaataata caatgttagg ggaatataca
     5221 tatgaataat ttagaaaata aaagttttga agtcttatct gataatcagc ttgagttagt
     5281 agaagggggt tcaggctatg gtgatggtgt agctggagga ctcacaggag gagctatact
     5341 aggcggtgta gtaaaagggg cccaaaatgg cgcgaaatat ggaagactag gtggagcatg
     5401 gggagttgcc gctggtgttg tagttggagg agccatcggt ggttacttag gatataaagg
     5461 ggcttgaaaa tcccttaact taagacgatc tgtttgatta acagattgtc tttctttttt
     5521 aaaataatta gaatcatgga gtatttagat gttctttaaa aagtaccaat atgtaaaaca
     5581 aattgatgaa aaagactgtg gagcagcttg tctagccact atattgaagc attacggctc
     5641 caaattatca ataaataaaa ttcgagatat tgcgggaaca gataaacaag gcacaagcgc
     5701 acttggacta gtcagagcag ctgaacaatt aggcttttca gcaaaaggag taaaagctga
     5761 caaaacagct ttagaagaac cctttacact gccggctatt gcacatatca ttcttaatgg
     5821 acaattatta cattatgttg ttattcataa aattacaaaa gaccagatta tcattgcaga
     5881 tcctggccgc ggaatcatta agtacacaaa aaaagaattt ttagaggttt ggacaggaat
     5941 cttaatttta ctgactcctt ctgaaacata taagatccat gtagagacca gtactatacg
     6001 aagtgatata ttcaaattaa tacttcatca aaaatcattg atcatccaca caattttagc
     6061 atcctttatc attacagttt tcggtattat ggggactttt tattttcaaa cggtcattga
     6121 tgagatttta ccaaatagat tgaatagcac gttacatata ctttcattcg gcctcatcat
     6181 tatgtactta tttaaagtcc ttttaacagc ctttaggcaa tatttaatga tattattggg
     6241 ccaaaaatta agtatttcaa taatgtttgg ttatttcaaa catgtactta gcttaccgat
     6301 gaagtttttt agcactagaa agatcgggga gattatatct agatttaatg atgctagcaa
     6361 agtaattgat gctattatta gcgcctctct atcagtagta cttgatacag taatgcttgt
     6421 aatggtaggc atctttttat atctacaaaa tacaacttta tttttaatta cattggcttt
     6481 tatcccattt tatgttctta cagtttggtt ttttatgaag ccatatgaat ccatcaacaa
     6541 tactgaaatg gaaaacaatg ctcagctgac ttcaaaaata gttgagacac ttaacggtat
     6601 tgaaacaatt aaagcatata atgctgaata tatgatgtca tatgagacag aaaagagatt
     6661 tgtgaaatat ttgcgctctg cttttaagca tggagttatc gataatcttc aaaattctat
     6721 taaaatgttt ttggatttag caagtggagc attcatattg tggattggtt caactcaagt
     6781 gatgaaagga actctttcaa taggtcagct cattacatac aatgcattgt taacatattt
     6841 tttgaatcct ttacagaaca taataggcct tcaatcgaaa ctccagtcag cttctgttgc
     6901 ttctaaacga ctgggagaaa tactagaagt agaacacgaa ataaaagata aggatgctca
     6961 aataacaacg ccagggtcta ttaatggccc aattgaattt attaaaatta actttcgata
     7021 tggtactcgg cgactaatcc taaaagatat tacactacgt atagataaag gggagaaagt
     7081 cgcttttatt ggagagagcg gttccggaaa atctactcta actaagctct taatgaaatt
     7141 ttatacagct gagtctggtg atattttaat taatggttat catatcaatg atattcatgc
     7201 tcattcatta agagaaagta taagttatat ccctcaagaa tctcacttta tacagggttc
     7261 catttttgaa aaccttctgc tcggtaactc aggcagtttt acctttgaag agattataga
     7321 agtatgcaaa caaacaaatg tacacgattt tgtcaatgat ttaccaatga gatacgatac
     7381 tctcgtagag gaaaacgggt ctaatttatc tggaggccag aagcaaagac tcgcaattgc
     7441 cagagcatta ttaagaaaac ctaacattct cataatggat gaatcaacaa gcaatctcga
     7501 tacgactacc gaacagggaa tatcaaaaat gatatacgat cagactgttg gtataactac
     7561 gattataatc gctcaccgtt tgagtacaat tatgaattgt gacaaaatat ttgtcatgga
     7621 aaatggagaa atcatagagt atgggaacca caatgattta ttgaagaaaa aaggcaagta
     7681 ctatgagttg tgggagaacc aaatgccatc cagagggatg gtgactattt agatgaaacg
     7741 taactttttc aatttacatg atttgaagga tagcagagaa ttctatgaat caaaacccaa
     7801 accaattggt gttttcttta catatatact gatagcttta cttattgcat gtattgtttt
     7861 tagtttctat ggaaagaaag aagtgattct aaaaacgaca gctgacatcc aatatacaaa
     7921 gcctaacagc aacgtaacaa acgaagtagc cggcaaagta aaaacagttg acattaaaca
     7981 ggttgataag gtgaaaaagg gagatactct attaactcta gacaatacgg aaatccaagc
     8041 gcagaaaaaa gctgttaaag cagatatcaa agatttaaaa gaacaagctg cgttaaacaa
     8101 aactctaaaa aaaagtattg aaaatgacaa aaatttattc agtgaggacg atcattgggg
     8161 ttatcaagat caatatctct cgtacgaaaa acaaagtatt ttgttagagt catcaaaaga
     8221 aaatgcaaaa actcagcaga aaaaacttaa gaagcagaaa gaaagcataa aagatagtct
     8281 ggataagaca aaaaacaaag tcaaactaaa gcttcaaaga atttctgatc tgcaagactc
     8341 cattaaaaac aataaatcct ttgccaaaca ggatgataag tacagttctt actataatag
     8401 ttatcaaact aacaaacaaa atgtagagca gcagtttgat gatctacgga agatgaaaga
     8461 tgagctcgat aaaaaccgtt tttcacagca gaaagagaac ttgaacggac agcttgaaag
     8521 tttaaaacaa gatatgttag taaaactaag tgaagaaaaa gacgaattaa atcaatctct
     8581 tgatgagatt aacagttcaa ttaaaagtga cgattctgac agtgattccg ataactcaga
     8641 ggaaacaaat tataagcttt ctattgaaca gctcaaaaca aacttgctaa atcagacatc
     8701 tcaaaagcaa acagatcttc agaccactct taaatcaaaa gaggatgatc taaagatgat
     8761 agatttacaa ttagaaaaat ataaaataaa agcagcaagt gacggctatg ttaatgtact
     8821 aacaaatata tctccaggtg acaatttaca agcaggcact gctattttga ctattatccc
     8881 tgataaagag aagcttaaag ctaatattta tattccgagt catgagatca caaatattaa
     8941 tgaaaaagat gaagtaagat tccatattga aaatacaaat caaaccatca aaggtgtcat
     9001 tacaaaaata agtccagaca gtattagtga tcaaaacgga caaaaatttt atattgctga
     9061 aagcacaata gagaaaaata aagttatgaa cgataacgga tcaactttac acttaaaaaa
     9121 tggaatgcag accgatgtat caattatagt ggattctaaa aggtacattg attctctact
     9181 agaaatacta catttacaat aatataataa atataaatcc aacagaggca atctgtttat
     9241 gggttactca ccggtctgaa ataatgtact tagaataagt gaaccactca aaataaacta
     9301 ttatgcaatt tcatttttgt ggatttattt cttgttttat gtaattatgc tataattaca
     9361 actaaatttt caacagaaag gtcaagcaat ttatgtcgca aaacaaacta ttatttttac
     9421 tcttttcatt ttcttctatc attcacttgc tcttcaatac gattttagat cctacttcaa
     9481 gctggaaatc ttggtcggtg aacattgcgc taattctttt agcccttcta tttttaaatt
     9541 tcactttgaa agaaaagaaa gaaactcaca agaccaagtg acataacgac acaaagcccg
     9601 gactgactat ccgggcaaat ttatatcctg taaacgttac ctctcttagg ttttcttttc
     9661 ataacatact gaagttactc tccggccttc catttcagcc actggctggt ttctctcgtt
     9721 tatagcaata caaccttata ctttttcaca tccaaaaact gcaaaaattc cctcgccagc
     9781 acttcaggcg gatgcgcctt tccttcatcc agccgataca aaagcaaccc aataatcatt
     9841 gcggatacat aatgggcata aagctttttc tctgcgtgaa tatcagtttg ctgatgcaga
     9901 taaaacgatt ccagcgcttt gaacatatca ggtatcacat gaggaacacc ccattcccga
     9961 ttgagaaaat agacaatggg catctttgac aaagcagaaa gcagactggc gagcgccttc
    10021 tccgcttcct ttaaggaaaa ttcattcggg ctggaggcaa tcgtgaggtg atcaatgatc
    10081 acctcacatg atcgctgtat catggtttgg agtaattcct ccttattggc atagtgatca
    10141 taaaaggttg cacggcggat attgcttttc cgggtaatat ccgaaattgt gatggctgcg
    10201 tagtcttttt tctccgccag cacgtccaga aatgccttct ggagcgcctc tctcgttcga
    10261 accacacgcc tgtcgatttg cttgtccttc tctcgctctc ctggcacagc ttgtccaaac
    10321 agccaataaa atctcttttg agaaacaagc tcccatacct tttggctgat agcttccgga
    10381 gtcgcggccg catcctcatt cagccaatac aggataatcg cgtacgtgta caaggcccgg
    10441 taatgtccgt aaatttcccg ttcgatcggc gtcaaattca catggaccgg agtcagcagc
    10501 acatcctgct gaaacacatc cctaaaaaaa cgatggaaat gccctctgtt catcatcaca
    10561 gaaaaaaagg atcgatgctc atgaacaaag gacagcgtcg gatgcaccgt ttgccgtttt
    10621 ttgttcaaat gaagggtatc catatgactg aaggcgtcaa aaagcgcttt gcccagtcct
    10681 tccttcatgt cttcgattaa atcctcaatg attgaaaact tatcctcata ataaaggtag
    10741 agcgatccgc ggctcacttt ggccttctca gcgatttctt tcattgtgat gtgttgaata
    10801 tctctatctt tcaataaggc cagcaacgcc tctttcactt gagcttcggc agattccggc
    10861 acaaaagaca cccccaatca ttagacagat cttcgatata tgtacggtaa cgtatagatg
    10921 gttcaccgtt gtctttctta cagaaaaggt accaccttat aataggtccg agaaaagaag
    10981 aaagcaaatg agggggattt tacaatggaa cagcaagtaa aggacgacat ccagcgtgtc
    11041 tttcagcttc agaaaaaaca gcaaaaagcc ttgcgcgctt caacagcgga acagcggaga
    11101 gaaaagcttc aacgcttttt agattccgtc atcgcccatg aagaagaaat catcgaagcg
    11161 atccgcaaag acgtccgcaa accatatcac gaagtcaaaa aagcggaaat cgaaggaaca
    11221 aaaaaagcga ttagagataa tatgaataac ctggaacaat ggatggcgcc taaagaagtc
    11281 ggttcatcgt taagccctga cgcaaacgga attcttatgt acgagcctaa aggcgtcaca
    11341 ctcatcctcg gcccgtggaa ctatccgttt atgctgacga tggcgccgct tgccgcttct
    11401 ctcgcagccg gaaacagcgc gattgtgaag ctgtccgatt tcacgatgaa cacgagcaac
    11461 attgccgcta aagtgataag agacgctttt gatgaaaaag aagtcgcgat ttttgaagga
    11521 gaggttgagg tggcaaccga actacttgat cagccgttcg accacatttt cttcactgga
    11581 agcacaaatg tcgggaaaat cgtcatgaca gcggctgcca aacacttggc atctgtcaca
    11641 cttgagcttg gcggcaagag cccgacgatt atcgacagtg aatacgatct gatggacgca
    11701 gcgaaaaaga tcgccgtcgg gaaattcgta aacgccggcc aaacctgcat cgcacctgat
    11761 tacctgttca ttaaaaaaga cgttcaggac cggttcgcgg ggattttaca aacagtcgtc
    11821 aacgctggat ttatggagga tgatcataac ccagaccgca gcaaatttac gcagatcgtc
    11881 aatgaccgca acttcaaccg cgtcaaagat ctgttcgacg atgccatcga aaaaggggcg
    11941 gaagtggtgt tcggcggcgt attcgatgcc agcgaccgca cgatctcgcc aaccgttttg
    12001 aaaaacgtca cgcctgacat gaaaatcatg caggaggaaa tcttcgcacc gatcctgcca
    12061 atgatgaact atgaagacat cgacgaggtc atcgattacg taaatgaccg cgataaaccg
    12121 cttgcacttt atgtgttcag caaaaaccaa gacctgattg acaacgtcct tcagcacacg
    12181 acatcaggaa atgcggccat caatgatgtc gtcgtccatt ttagtgacgt caacctgcca
    12241 ttcggcggcg tcaacacaag cggaatcggc tcctatcatg gggtatacgg attcaaagag
    12301 ttttctcatg agaagggtgt atttattcaa gcctctaaat aatcgtaatg aagagaatct
    12361 gcatcatctt gcaggttctt tttttatcat tctattcacc taaagataaa aaggtaaaat
    12421 aaagaaatga atagtgataa aataccattt tcactacgag accaaatccc tctagtctat
    12481 ctcattgaaa ccgcacagcc tctaacgtat aatatcccag aaaacttcaa aggagagaat
    12541 attatacatg gaaaaaccag ctggattttg gattcgggca gttgcctcta ttattgatga
    12601 tttaattatc tatttttttg cttttattat gatccaaatt aacaccttaa ttgtcctgcc
    12661 tctcattgat gcagggagct cctatatgac agaaggtcaa tataaatttt atatcctgat
    12721 attcggaacg at
//
