LOCUS       gnlProkkaFOEBKJKK_116  14280 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FOEBKJKK_116.
ACCESSION   gnlProkkaFOEBKJKK_116
VERSION     gnlProkkaFOEBKJKK_116
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 11:27:51
            Original ID  :: gnl|Prokka|FOEBKJKK_116
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 106132
            Orig. end    :: 120412
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14280
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9280]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9280
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14280
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14280
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(499..1302)
                     /locus_tag="ctg75_83"
                     /transl_table=11
                     /translation="MATTYDGINYFPIAVNFMEENAMEVIEAKYGMKGLAIVLKLLCKI
                     YKEGYYIPWGEEQCLIFANKTGKEADAEEVQGIIEIMIEKGMIDRGSYAEHKVLTSKAI
                     QKVWIEATKRRKRNWTAMPYLLIKPKETCNEEKTVCTQNVEQDAGSDAKNACNTEQSKV
                     KQSREFPPSAPPRGKEEEVNATPVSMPGYAFNTMTHNYVGLMGNLERFGITDEKEIEAI
                     LRLSDYGRKGTPVWKLICSTNWSNIGAKGKYMIAALNRAKKRSGT"
     CDS             complement(1352..1699)
                     /locus_tag="ctg75_84"
                     /transl_table=11
                     /translation="MKKNRKAVSKNEMMKGKWKRQIMLEKDYTEQCSEWMAERLEALIE
                     YMQYGHAAVAYMKQDGTFKLVKGTLVGYEKDFGKQYDPMEIKNTVVYRDVEQQRWMTFK
                     IENFMEWRAIV"
     CDS             complement(1840..2178)
                     /locus_tag="ctg75_85"
                     /transl_table=11
                     /translation="MNDNLVTIEVNGKVIFAGKADLQFSLNQKVREPLRITKGKGKLME
                     ALTESFIKGGINSMENRPIEELQETIKEYLTFEYQRKGIATEPNKRSFLSELKKYARAF
                     RKKRDESE"
     CDS             2700..3224
                     /locus_tag="ctg75_86"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             3228..3713
                     /locus_tag="ctg75_87"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             3710..4993
                     /locus_tag="ctg75_88"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             5001..5705
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_89"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.3e-14, bitscore:
                     47.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIMAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIER
                     IILGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLV
                     FERKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDCNHILTSCSVDKDALEAKGELVGI
                     HKLSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEAD
                     LSYAEEHIIRYC"
     CDS             5725..7026
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_90"
                     /sec_met_domain="CTP_transf_like (E-value: 4.3e-12,
                     bitscore: 39.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.6e-121, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 7.8e-64, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             7038..8174
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_91"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.6e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-20, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             8171..9280
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 2.7e-33.
                     Score: 107.2. Matches aSDomain:
                     nrpspksdomains_ctg75_92_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 79.2; E-value:
                     4.8e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_92"
                     /sec_met_domain="Aminotran_5 (E-value: 4.9e-30, bitscore:
                     98.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHD
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIVGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMKSVNTVLVNK"
     aSDomain        8261..9049
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg75_92_Aminotran_5.1"
                     /evalue="2.70E-33"
                     /label="ctg75_92_Aminotran_5.1"
                     /locus_tag="ctg75_92"
                     /protein_end="293"
                     /protein_start="30"
                     /score="107.2"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHDAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIVGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             9293..10111
                     /locus_tag="ctg75_93"
                     /transl_table=11
                     /translation="MLKKRLDYSQLKVIQLNILKDVDAFCRENNITYYLTYGTLLGAVR
                     HQGYIPWDDDIDIAMPRKDYEKFLSNYNLNGSKKNVYQVVAIELNNAYPYPFGKVQDLS
                     TVLLEYSDINYPLGINIDIFPIDGLPVDLKKSDKHFLKIKWLMMIMNLKKVKITIKRSF
                     LKNLILLIGKILTLLIPYRFIVRKMSYIAQRYDYEKSDYVSNLSCPDGKHERTSKRVFE
                     NSIEILFEGNNFYAPIGYHEWLHNIYGDYMKMPPVPERVSHHKFEIYKIL"
     CDS             10114..11109
                     /locus_tag="ctg75_94"
                     /transl_table=11
                     /translation="MCSKDNFLQEVRALCIFTVILLHVPFQGHDNISFNTWLMSKQLIT
                     FPVAVFFFLSGYFYSFRNYKSRIVKLLCPFLFWNMSVHLIKFIRGESGFNIENFLLGNG
                     LPYYYLAVLLQIVLFHYIIFKYWSEMVYRVLSISISIISLMAYYYFSISYSIHFNCYLY
                     FPFWILFYTLGTFGKKYWRNLISKIPFCVILLFILISVFLMFFEANLMYYILFQEGIAG
                     SQVKFSSWVYSILIVLLLLKIDYSIDENVTRNFGTLIGDYSYGVYLIHIFILSLIYKLC
                     IVVFNDNYNVLLPFIAASITLVISVFMIYILNKCLPPFILKFLGLYVKSN"
     CDS             11093..12265
                     /locus_tag="ctg75_95"
                     /transl_table=11
                     /translation="MLKVTDECTACGACLSICPKSCISFKSNEEGFLYPHIDIEKCVDC
                     DLCSKVCFLNDHITPTFRENDISYYAAKAIERCNLSSSGGIFPLLAESVLKNDGVVIGA
                     AWDDKFNVKHILIKSKSELPLLCGSKYIQSNTEKVFKIVKEHLSIQTVLFSGTPCQVKG
                     LKTFLGKDYDNLITVELVCHGVPSPLVFRRYLNGVLKYNNLDISQCSKINFREVKDDIY
                     RFVIYNKTKIPFYEQYTNLYTKTFLQNLFLRNSCYNCKCKLENSVGDFILGDFWGCRDF
                     YPEFYDPKGVSLVIVCTERAKKIWLNLKLSRIEVKKKIVFRSNRHLLKSASYNRNRDLF
                     FKTFIHEAEISLDDILMGYTNKDIWVKVKGLIISALRFVGLFQLVQLYRK"
     CDS             12262..13320
                     /locus_tag="ctg75_96"
                     /transl_table=11
                     /translation="MKIALLTLPFVNNYGGILQAYALKHFLELRGHSVCIIDRNSNFKI
                     SFIDILRLAKRKFLGNRIRNFAYFKKQYLLPMTSEIITNKEMLLLDEKYQFDIYIVGSD
                     QVWRAIYYRDIKYNFYLDFVSSKRKISFAASFGISSWEYTNTETDIIAKLLMDFSFVSV
                     REDTAVRLCSDYLNINAVQFLDPTFLLDKNEYCCLADCFYSSKKIDIFAYIMGPDSSKD
                     KLIKIISDYSGLSVQSITQSKFSFKKNESIQEWLQNFYKSKFVVTDSFHGLAFSLIFNK
                     PFIVCGFSNRGMGRYESLLRYFSLENRLLYSLEDLKELNLSTIWDINWKEVNAKIAENK
                     RFVLELMQTVGV"
ORIGIN
        1 cgttggcagg aagaaagacc gcattgtgta tttgcaatgt gcacctctgc tcaatgatga
       61 ttttcaagtg gagcaaatgt acaacacgct ggagatgata caagacaatt atgaaaagtg
      121 ggtcgtttct atggacgata ccacattgcc ctccaaagaa gggattcgtc acatacaagt
      181 ctggcaactg cctgaaatac tatagtctga caatcttttt tgattgcttt gatgtccgga
      241 tgatgccgtt tacgaagtta acatcttgtt gtttacgaag ttaatatcat aattttacga
      301 agttaaaatc gtatcttcgg gaagttaact tcctgaagtc acgattttaa cttcgtatta
      361 gtgctttttg aatcgctttt caaccccttg agaatcagtg ctcgtttccg gaggaaaaca
      421 gctgcgttct ttaattgact gcaagcaaac agcattttcc agaatataaa aatgtactgt
      481 ttgtcagaaa agttcttttt aggttccgct tcttttcttt gcccggttca acgctgcgat
      541 catgtatttt ccttttgctc cgatgttgct ccagttcgtg ctgcaaatca gtttccatac
      601 aggggttcct tttctcccgt aatccgacag tcgcaggatt gcttcgatct ctttttcgtc
      661 tgttattccg aatcgttcca ggtttcccat taatcccacg tagttgtgtg tcattgtatt
      721 aaatgcgtat ccgggcatac tgaccggcgt agcattgact tcctcttcct tcccccttgg
      781 gggagctgag gggggaaatt ctctactttg ctttacttta ctttgttcgg tattgcatgc
      841 attttttgca tcagagcctg catcctgctc tacattttgc gtgcagacag tcttttcttc
      901 attacatgtc tctttcggtt ttatcagtag ataaggcatg gctgtccagt tcctctttct
      961 tcgcttggtt gcctctatcc atactttttg tattgcttta gaggtcagta ctttatgttc
     1021 cgcatagctt cccctgtcta tcattccttt ctcgatcatt atctcgataa tcccctgcac
     1081 ctcttctgcg tctgcctctt ttcccgtctt gttggcgaaa ataaggcatt gttcctcacc
     1141 ccacggaata taatatcctt ctttatatat cttgcatagg agtttcagta caatcgcgag
     1201 tcctttcatg ccatattttg cttctattac ctccattgcg ttctcttcca taaaatttac
     1261 agctatcgga aagtaattta ttccatcgta tgttgttgcc ataattgtta agttgttatg
     1321 ttgctgatta attggtcact gaaagattct cctatacgat cgctctccat tccatgaaat
     1381 tctctatttt gaaggtcatc cacctttgtt gttccacatc ccggtagacc actgtgtttt
     1441 ttatttccat cggatcatac tgctttccga aatctttttc gtatcccacc aatgttcctt
     1501 tcaccagttt gaatgttccg tcctgtttca tataagctac ggctgcatgt ccatattgca
     1561 tatattctat gagggcttcc agtcgttctg ccatccattc ggagcactgt tctgtgtagt
     1621 ccttttcgag catgatttgt cttttccatt ttcctttcat catttcgttt ttcgatactg
     1681 ctttcctgtt ctttttcata attgattttt ttaagtttat taatgagtta ttgtcgggct
     1741 tttattttta cccatggcaa agtacggtaa taagttttga atagactaat cctgtaaaag
     1801 tactttagaa aggggctttt acaggatttt aacaatcggt tattcgcttt catctcgctt
     1861 tttccggaat gctctggcat attttttcag ctctgataga aaagaacgtt tattgggctc
     1921 tgtagcaatg cctttgcgct gatattcaaa ggtgagatat tcttttattg tttcttgtag
     1981 ttcttcaatg ggtctgtttt ccatgctgtt gattccgcct ttgataaagc tttcggtaag
     2041 tgcctccatt agctttcctt tgccttttgt gatgcgtagt ggttctctaa ccttttgatt
     2101 gaggctgaat tgcaagtcgg ctttacccgc aaagattact tttccattta cttcgatggt
     2161 tactaagtta tcattcaatg agataactac tttttttctt ccataatgtt agttattaaa
     2221 tgaatttatg aaaggacaaa gtttgtataa aaaaatataa atataaaaga ataccggagt
     2281 ttttttagct taaagggaga atcttgaact gtaaggatct tgttattagt tatttatctt
     2341 aagatatagg tgttgtttca aaaaacgttc gtcttttgaa acagcatttt ttgagttttt
     2401 ttcgatgaaa aaatgaatat tgtaaagttg ctgagcagag aacttttttt gctctatatg
     2461 tgtttgaaaa tcaacaatat aaaatctttg ataaaatttt atccactaaa tattttgtac
     2521 attaaaacag actccttacc tttgttaaat caaacgaacg ttttttgaaa cacattcgtt
     2581 cgttctcaac ttctaaaaat gtttcgtaaa atttgacggt ttgaaagaga aaagatgtct
     2641 cgttcaaacc gcgaagcgca cccgaaacaa aggaaaattt ccccaagtat aaatcgtaaa
     2701 tgtctgaaca acagaagtat tggtttgccg cccgtacacg agataaacaa gagtttgcta
     2761 ttcgtgactc tcttgaaaaa ttgaagactg aacttgatct caattactat cttcccactc
     2821 agtttgtcat ccggcagttg aaatatcgtc gaaaacgggt ggaagtccct gttattaaga
     2881 atcttatctt catccaagct accaagcaag atgcttgtga tatttctaat aaatacaata
     2941 tccagctttt ttatatgaaa gacctgctta ccagggctat gctgatagtt cctgataaac
     3001 agatgcagga cttcatattt gtcatggatt tagatccgaa tggcgtcagt ttcgataatg
     3061 accatttatc tgtcggtagc agggttcagg tagttaaagg tgatttctgt ggtgtcgagg
     3121 gcgaacttgc cagcgaggcc aacaaaactt atgttgttat tcgtattgcc ggtgtattga
     3181 gcgccagcgt caaagttcct aaaagttatt tacgtgtcat ttaagttatg aatacactca
     3241 cttctcaaat tgaacaatta cagagtctcg cgcacgagtt actctattta ggtgtggatg
     3301 gtgctcctat ttataccgat catttccgtc agttgaacaa agaagtttta gaacaatccg
     3361 atgcgttgta tcctcagcgt ggtgctactc ccgaagagga agcaaacatc tgtctggcat
     3421 tattgatggg ttacaatgca accatctata atcagggtga caaggaggag aaaaagcaag
     3481 ttgttctcaa tcgttgttgg gacgtgcttg accaacttcc tgctacttta ttgaaatgcc
     3541 agttgttgac ttattgttat ggtgaggtgt ttgaagagga gttggcgaaa gaggcgcata
     3601 ctatcataga aagttggagc aatcgagaac ttttaaaagc tgaaaaagaa atagctgaaa
     3661 gtttgaataa tttggaagct aatccatatc cgtacagcga actacacgaa tgattcgttc
     3721 ctttctttcc cgttctcccc tttacgtttt ggctctctat gccagcgttt tgatttttct
     3781 ggtttatact tgtgcctatg cctaccgtaa gccatttact gcagccattt atgaaggtga
     3841 gattctttgg ggattcgatg tcaaaatcct gtatgtcctt tctgagatta tcggctacgc
     3901 cctttccaag ttcatcggtg ttcgtatttt gccttcgatg aaagcgggtc accgcatcta
     3961 ttatataata gggctgctta ctttttccga agttgctttg ttgggttttg cacttcttcc
     4021 ggttcctttg aaggtgtgtt ctatttttct gagcggtctt cccctgggta tgatctgggg
     4081 tgtcattttt agctatatcg aagggcgtcg tatcagtgaa atattgaatg tcgggctgag
     4141 cgttgctttg atagtctctt ccggtttggt gaaaaccttg ggacaattcg tgatggataa
     4201 tttgcatgtg tcggaatatt ggatgccttt taccaccggt ttgttggtat accctgttat
     4261 gttgctttgc agctggcttc tcaatcagat tccggctccc aatgagcaag atatcataca
     4321 gcgtaccaaa cgtgctccga tggatggtaa agacaggcgt aagtttttga ggcaattctt
     4381 ttggggaatc tgcatgctgg ttgtttttta cggtgccctg accgtgttcc gtgagcttcg
     4441 tgactctttc gctgccgata tttggaagga gctccatatt gagggtgcaa tgatctttac
     4501 tcagacagag gttcccattg ccgtttttgt ccttgtactg atgttcctga ttgtgtttgt
     4561 ccgtaataac cgtttggctc ttaatatcat ttattgcatc gccgtcacag gcggttcctt
     4621 aatggttttt tccacattgc tttatgtgta cggttttctt tctcctattt ggtggatgat
     4681 tctttccggt cttggtctgt atatggggta tattcctttc acttacctga tagaacgtct
     4741 gattgcttcc cttagggtgg ttagtacagc tgtttttatt atttatttgg ccgattcttt
     4801 cggctatctg ggcactacgg gtgtgtttat ggtcaagaac ttcgtttctg ctgacatttc
     4861 ctggactgtc atgctgatgc gtactgccct tttttcagga tttgtttctg tcctgtcgat
     4921 ttttgcgatt tactgttatt tcaagcaaca attgaattca cttatattaa ttccctctga
     4981 aattcatgat taaaacagca atgatcatgg ctgccggtct tggtacccgc ttcgggcatt
     5041 ataccgagct tgtgcccaaa ggttttgtgg aggttggtgg aaaacctatg attatccgct
     5101 ctatcgaaac ccttctttcc tgcggtatcg aacgtatcat cctcggtacg ggttataaaa
     5161 aagaggctta tgaagccctt caggcggatt tcccccagat agagacctgt ttcagtcccc
     5221 gctatgccga tactaacagt atgtacactc tgtacaatac gcgtgacgtg ataggcgatg
     5281 acagtttcct gctgcttgaa tcggaccttg tttttgaacg caaggccatc ctctcgctgc
     5341 tggatgacga attcccggat gtgatgcttg tctcctctct gaccaagttc caggatcagt
     5401 attatgtgga atatgactgc aatcacatcc ttacttcctg ttcggtagac aaggacgccc
     5461 ttgaggcaaa aggcgagctg gtcggcatcc acaaactttc caatactttc taccgccgga
     5521 tgtgcgccga ttatgcgacc atcctggagt cccagcctaa actgggttac gaatacgaac
     5581 tgctccgcat gtcccgttcc gtttcccctg tccgtgtgct cagggtggag gggcttaaat
     5641 ggtatgaaat cgatgatgaa gccgaccttt cgtatgctga ggagcacatc atccgctatt
     5701 gttaaaaaca aatcttttcc atatatgaac aagaaaatct atgtcggtat gaccgcggat
     5761 atcatgcatc cggggctgat ccatattatt catgaagcta ctaaatacgg tgatgtcatc
     5821 gtcggtctgc tgacggacaa ggccatcgcc gaacacaaac gcctccctta ccttacctat
     5881 gatcagcgta aggaggttgt tgagaatatc aaaggggttt gcgaagttgt tccccaggag
     5941 gattggagct atgttccgaa tctggaaaaa ctcaagcctg actatatcat ccacggtgac
     6001 gactggaaaa cgggcccgtt gcgcgaggtg cgcgaacagg tttttgaggt gatgaacgcc
     6061 caggggggca aggtaatcga gatcccttat acccggggca tcaactcctc ctcgctcgac
     6121 aaggatatca aggcgatcgg gactacccct gacgtacgtc ttaagtccct ccgccgcctg
     6181 atccaggcca agcctgtggt ccgtatcctg gaggctcacg acggtctttg cggtctgatt
     6241 attgagaatc ttgaagtcca gaagggtgat aagcgcgagg tctttgacgg catgtggtcc
     6301 agcagcctga ccgactccac gagtaagggt aaaccggata ttgaagcggt cgaccttacc
     6361 acccgtttac aggacctgaa caatatcctt gaatgcacca ccaagcctat tatttttgat
     6421 ggagacacgg gtggcaagat cgaacacttt gtctttactg tgcgcacttt ggaacgtcac
     6481 ggcatttctg cggtaatcat tgaagataaa gttggtctga agaagaattc cctttttggt
     6541 actgacgcta tccagactca ggatagtatc gagggtttct gcgataagat cagagcaggg
     6601 aagaatgccc aggtcaccgg tgactttatg atcattgcgc gtatcgaaag ccttattgcc
     6661 ggcaaaccca tgagtgacgc cctcgaacgt gcttatgcct atgtacaggc gggtgcggac
     6721 ggcatcatga tccacagcaa ggataagtcg ggtgaggata tccgtgagtt ctgccggact
     6781 ttccgcaaag aatacgccca tgttcccatt gtcgttgttc cgacgactta tgaccatgtg
     6841 cacgaatccg aacttcacga atggggtgcc aacgtagtca tttacgccaa ccaccttctc
     6901 cgtgccgctt acccggccat gatgaacgtg gccaggacca tccttgaaaa cgagcgcgcc
     6961 gaggaggtcc gtccgctttg tatgcctatc aaggaaattc tggaattgat tccgggcact
     7021 aaataaatca gacggttatg gtaagtgtag aaaagatata cgatacgttc cttcatcacg
     7081 gtgttgactt ctttacgggt gttcccgatt cccttttgaa gaatatttgc gcctatatca
     7141 cggatcatgc tccgcgtggt aagcatatca tcgccgccaa tgaaggttcc gcggtgggca
     7201 ttgcctgcgg ttattatatg gcttctggca acgttccttt ggtttatatg cagaactccg
     7261 gtctgggaaa tacggtgaat cccctcttgt cccttgcgga cgagaaagtg tacagccttc
     7321 ctcttctttt gctggtcggc tggcgcggtg agcccggcac gaaagacgaa ccccagcata
     7381 agaagcaggg cgaggttacc cttgatcttc tgaaagccat gaaaattcct tttataattc
     7441 tggatacgga tgaagacgag gccctggcgc agatccatga cgcggttgtc tcggcgaaga
     7501 gccggtcgat tccccatgcg attgtcatcc gtaaagatac gtttggaaaa tataaattgc
     7561 gtcaggaagc cttgaatgac tatcctctgt cccgcgagga ggcgctaatg caggttgtcg
     7621 accacctcgg ggacaatgac attgtggttt ccaccacggg caagctctcc cgtgagcttt
     7681 tcgagtaccg cgaatcgaaa gggcaggggc acgcaaggga tttcctaact gtgggttcca
     7741 tggggcacag ttcttccatt gccctgggga ttgcccttga gaagcctgac cgccgtgtct
     7801 actgtcttga cggtgacggt gcctttatca tgcacatggg tgctgtcagc aatatcggcg
     7861 atctttctcc caagaattac aggcacgtcc ttttcaacaa cggtgcccat gaatctgtcg
     7921 gcggtcaacc cacgctcggt ttccgtctgg atatcgcctc gatagcgaaa ggttgcggtt
     7981 atgcgcatgt actgactgcc tccgacaagg aagggctttc gtgtgcgctt gagaagctgt
     8041 ccggcctgtc cggtccggtt cttcttgaaa ttaaggtccg gatcgattca cgtgatgatc
     8101 tgggtcgccc tacgactact ccggtagaga ataaagagca ttttatggca tttttaaaag
     8161 atacgcattc atgaatatcg aaagaaagat ccttttgaat ccgggtcccg ccaccacgac
     8221 ggatacggtg aagctggcgc aggttgttcc cgatatctgt ccgcgtgaga aagagtttgc
     8281 gggtatgatg aaacagttac gtgacgacct ggtccgcgtt gcgcatggag acctctccaa
     8341 acatacggcc gtcctgtttt gcggctcggg tacgatcaat atcgatatct gcctgaactc
     8401 tcttcttcct gcggataaga aagttctggt tgtcaataac ggtgcctaca gcacccgtgc
     8461 ggtggaagtc tgcgaatatt acggtcttcc ccatatcgat ttgaagtttt ccgtttacga
     8521 acttcccgac ctgtcggtaa tcgaaaagac gctttccgac aatccggaca tcgctttggt
     8581 ctataccacg caccatgaaa cgggtacggg tatcttgaac cccatccgtg agatcggaaa
     8641 aatagcccat tcgcacgatg ccgtttttgt tgtcgacacc acttcttccc tgggtatgat
     8701 tccttttgat atcgggaagg ataatgttga cttttgtatg gcttcggctc agaaaggcct
     8761 tcaagccatg acgggtcttt cctttatcgt aggtgatgaa tccctgatac gtgcttcaag
     8821 ggattatccg aaacgttcct actattgtaa cctctattta caatacgatt actttgagaa
     8881 gacgggtgag atgcatttta ctcctcctgt tcaaaccgtt tacgctgccc gtcaggctct
     8941 tgatgaatat tttgcagtag gtgaagaggc taaattcgcc cgtcacaaga gggtctttga
     9001 agccatccat aaaggtttgc aagagcttgg tcttcagtat gcgatcaaac gtgaatggca
     9061 gtcgggtctt gttgtttctg tattgtatcc tgatgatccc ctctgggatt ttgataaggt
     9121 tcatgattac tgctatgaac gtggctttac gatctacccg ggtaagattt ccacaacgaa
     9181 tacattccgg ctttgtgcgt tgggagagat tgatgtggag gatattgaga ggttctttga
     9241 ggtgatgaaa agcgtaaata cggtattagt taataaataa tttagctcat tcatgttgaa
     9301 aaaaaggttg gactattccc aattaaaggt tatacagttg aatatattaa aagatgtaga
     9361 tgctttttgt cgtgaaaata atataactta ttatttaact tatgggactt tgttgggggc
     9421 tgtaagacat caaggatata ttccttggga tgacgatatt gatattgcta tgccgaggaa
     9481 agattatgaa aagtttttat caaattataa tctaaatgga agtaaaaaaa atgtgtatca
     9541 agttgttgct atagagttaa ataatgctta tccttatcct tttggaaagg ttcaagattt
     9601 atcaactgtt ttattagaat attcagatat taattatccg ttggggataa atattgatat
     9661 tttccctatt gatggattac ctgtagacct taaaaaatca gacaaacatt ttttgaagat
     9721 aaagtggtta atgatgataa tgaatcttaa aaaagtaaaa ataacaataa aacgttcttt
     9781 tttgaagaac ttaatattat taatagggaa gattttgaca cttttgattc catatcgatt
     9841 tatagtgcgc aaaatgtctt atattgcaca gaggtatgat tatgagaaat ctgattatgt
     9901 ttctaacttg tcttgtccag atgggaaaca tgaacggacg tctaaaagag tttttgaaaa
     9961 tagtatagag attttatttg aaggtaataa tttctatgct cctataggat atcatgaatg
    10021 gcttcataat atttatggag attatatgaa aatgcctcca gttccggaaa gagtatctca
    10081 tcataaattt gaaatttata agatactgta atcatgtgtt ctaaggataa ttttcttcaa
    10141 gaagttcgtg cattatgtat atttactgta atattgttac atgtaccatt tcagggacat
    10201 gataatataa gttttaatac ttggctaatg tcaaagcagt tgattacttt ccctgttgct
    10261 gtgttcttct ttttatctgg atatttttat tcttttagaa attataagag tagaattgtt
    10321 aaattgcttt gtcctttttt attttggaat atgagtgtac atctaattaa gtttattaga
    10381 ggggaaagcg gatttaatat tgaaaatttt ttattaggta atggattacc ttattattat
    10441 ttagcagtac ttcttcagat tgtgttattt cattacataa tctttaaata ttggagcgaa
    10501 atggtatata gagtattgtc cataagtatt agtattataa gtttgatggc ctattattat
    10561 ttttccattt cttattctat ccattttaat tgttatctct attttccctt ttggatatta
    10621 ttctatactt taggaacatt tgggaaaaaa tattggcgta atttaatatc taaaatacct
    10681 ttttgtgtaa ttctattgtt tattttaata tctgtctttt tgatgttttt tgaagctaat
    10741 ttaatgtatt atattttgtt tcaagaggga attgccggct ctcaggttaa gttctcttcc
    10801 tgggtgtatt ctatactaat tgtgttgctt ttacttaaaa tagattattc aatagacgaa
    10861 aatgttactc gaaattttgg tacacttata ggtgactatt catatggagt ctatttaatt
    10921 catatattta tattatcttt aatttataaa ttatgtattg tcgtttttaa tgataattat
    10981 aatgtattat tgccttttat cgcagcttct ataacattgg ttatttcagt ttttatgatt
    11041 tatattttaa ataaatgtct tcctcccttt atacttaaat ttttaggatt gtatgttaaa
    11101 agtaactgat gaatgtacgg cttgtggagc ttgcttgtct atatgtccaa agagctgtat
    11161 ttcttttaaa agtaatgaag aaggtttttt atatccacat attgatatag aaaaatgtgt
    11221 agattgcgat ttgtgttcta aagtttgttt tttaaatgat catattactc cgacttttag
    11281 ggaaaatgat atcagttatt atgcggctaa ggctattgaa cgatgtaatt tgagctcttc
    11341 tggaggaata ttcccattgc ttgcagaatc agttttgaag aatgacggcg tagtaatagg
    11401 agctgcttgg gacgataaat ttaatgtcaa acatattctt attaaatcaa aaagtgaact
    11461 gccattatta tgtggttcaa aatacataca gagtaataca gaaaaggtct tcaagatagt
    11521 taaagaacat ctgtctattc aaactgttct tttctcagga acaccttgtc aagtgaaagg
    11581 acttaaaaca tttttgggaa aagattatga taatttgatt acagtcgaat tggtttgtca
    11641 tggagttcct tcaccattgg tttttagacg gtatttgaat ggggttttga aatataataa
    11701 tttagatatt tcacagtgta gtaaaattaa ttttagggaa gtaaaagatg atatctatag
    11761 atttgtgata tataataaga ccaaaatacc attttatgaa caatatacaa atctttatac
    11821 taaaacattt cttcaaaatt tattcttacg taattcttgt tataactgta aatgtaaatt
    11881 ggaaaattcc gtaggagatt ttatcttagg agacttttgg ggatgtaggg atttctatcc
    11941 tgaattttat gatccaaaag gagttagctt agttattgtt tgtactgaac gtgcaaaaaa
    12001 aatatggtta aatttaaaat tatcaagaat agaagttaag aaaaagattg tttttagaag
    12061 taataggcat ttattaaaat ctgcatctta taatagaaat agagacttgt tctttaaaac
    12121 ttttattcat gaggctgaga tatcactaga tgatattttg atgggataca caaataagga
    12181 tatttgggtt aaggttaagg gtttgataat tagtgcttta cgttttgtgg ggcttttcca
    12241 attagttcaa ttgtatagaa aatgaaaata gcattactta ctttaccatt tgttaataat
    12301 tatggaggaa tattacaagc ttatgcttta aaacattttt tagagttaag agggcatagt
    12361 gtttgcatta tagatagaaa ttcaaatttt aaaataagtt ttattgatat attacgtctt
    12421 gcaaaaagga agtttctggg aaatagaatt cgtaactttg cttattttaa gaagcaatat
    12481 ttattaccaa tgacatctga gattataact aataaagaaa tgttattgct tgatgaaaaa
    12541 tatcaatttg atatttatat tgttggtagt gaccaggttt ggagagcaat atattataga
    12601 gatattaaat ataattttta tttggatttt gtgtcgagta agaggaagat atcctttgcc
    12661 gcttcttttg gcatatcttc ttgggaatat acaaacactg aaactgatat tattgcaaaa
    12721 ctgttaatgg atttttcttt tgtttctgtt agagaagata cagcagtaag gttatgttct
    12781 gattacttga atattaatgc tgtgcaattc ctagatccaa ctttcttatt ggataaaaac
    12841 gaatattgtt gtcttgctga ttgtttttat agttctaaaa agattgatat ttttgcttat
    12901 ataatggggc ctgattcatc taaagataaa ttaattaaaa taataagcga ttattctggc
    12961 ttgagtgttc aatctataac tcaaagtaaa ttctctttta aaaagaatga aagtattcaa
    13021 gaatggctac aaaattttta taagtcgaaa tttgttgtaa cagactcttt tcatggttta
    13081 gctttttctt taatatttaa taaacctttt attgtttgtg gctttagtaa tagaggaatg
    13141 gggagatatg aatctttatt gagatatttc tctttggaaa atagactttt atattcattg
    13201 gaagatttaa aagaactaaa tttatctact atttgggata taaattggaa ggaagttaat
    13261 gctaaaattg ctgagaataa aaggtttgta ttggagttaa tgcagacggt aggtgtataa
    13321 tgtcacttaa agaaaataca atttatggtg tactgtggag ttcatttgag aaatttggaa
    13381 ctttatcgat acaatttatt tacatgattg tgatggcaag attgctatct ccttctgatt
    13441 ttggtatagt tggcatgttg acaattttta tttctgtagg ccaagttata cttgatagtg
    13501 gttttggaca ggctttaata agattacaaa aatatgatga tttacatttt tcttcaattt
    13561 ttataattaa tgttattatg ggagttctac tctatggaat attattttat atggctccat
    13621 atatttcttt attctataga gaacctagct taacattaat ttcaagaata tcttttttga
    13681 tttttcccat caattcacta agtatagtcc aatatacttt attagtgaaa aaaatggatt
    13741 ttaaatctat ttctaaaata tctttattct cgataatttt atctacaatt tcaggtatta
    13801 catatgggta tttttaccct aatatatttg cactattaat tcaaaatgtc tcattttatt
    13861 tttataggct acttttatta tggtattatg gaaactggaa attatcatgt cgaatttcat
    13921 ggagtaaatt acaagatttg atgccattct cttttacgtt attagctaca ggctttattt
    13981 ctactgtcgt aggagagttg tattcattgt ctattggtaa gttcttttct tcatctgttt
    14041 taggtttata ttctcaagca gaaaggtttt cgaaaattcc atctttttct ataacagatg
    14101 ttgttcaacg tgtgacttat cctgcattat cagtgttaca agacgatgat caaaaattaa
    14161 agcattcata tagaatggtt attatgtgca cattctttat agtattgcct gtaatgcttt
    14221 ttctttttat tagcgctggt gaaatttttg aattattatt tactgaaaaa tgggaacagg
//
