LOCUS       gnlProkkaGBDADMNG_12   14271 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GBDADMNG_12.
ACCESSION   gnlProkkaGBDADMNG_12
VERSION     gnlProkkaGBDADMNG_12
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 15:58:16
            Original ID  :: gnl|Prokka|GBDADMNG_12
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 24561
            Orig. end    :: 38832
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14271
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9271]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9271
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14271
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14271
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(499..1302)
                     /locus_tag="ctg12_20"
                     /transl_table=11
                     /translation="MATTYDGINYFPIAVNFMEENAMEVIEAKYGMKGLAIVLKLLCKI
                     YKEGYYIPWGEEQCLIFANKTGKEADAEEVQGIIKIMIEKGMIDRGSYAEHKVLTSEAI
                     QKVWIEATKRRKRNWTAMPYLLIKPKETCNEEKTVCTQNVEQDAGSDAKNACNTEQSKV
                     KQSREFPPSAPPRGKEEEVNATPVSMPGYAFNTMTHNYVGLMGNLERFGITDEKEIEAI
                     LRLSDYGRKGTPVWKLICSTNWSNIGAKGKYMIAALNRAKKRSGT"
     CDS             complement(1352..1699)
                     /locus_tag="ctg12_21"
                     /transl_table=11
                     /translation="MKKNRKAVSKNEMMKGKWKRQIMLEKDYTEQCSEWMAERLEALIE
                     YMQYGHAAVAYMKQDGTFKLVKGTLVGYEKDFGKQYDPMEIKNTVVYRDVEQQRWMTFK
                     IENFMEWRAIV"
     CDS             complement(1840..2178)
                     /locus_tag="ctg12_22"
                     /transl_table=11
                     /translation="MNDNLVTIEVNGKVIFAGKADLQFSLNQKVREPLRITKGKGKLME
                     ALTESFIKGGINSMENRPIEELQETIKEYLTFEYQRKGIATEPNKRSFLSELKKYARAF
                     RKKRDESE"
     CDS             2700..3224
                     /locus_tag="ctg12_23"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             3228..3713
                     /locus_tag="ctg12_24"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             3710..4993
                     /locus_tag="ctg12_25"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             5001..5705
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_26"
                     /sec_met_domain="NTP_transf_3 (E-value: 6.5e-14, bitscore:
                     47.3, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIMAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIER
                     IILGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLV
                     FERKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKGELVGI
                     HKLSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEAD
                     LSYAEEHIIRYC"
     CDS             5725..7026
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_27"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-11,
                     bitscore: 39.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 4e-121, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2e-63, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             7038..8174
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_28"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6.5e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.1e-19, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             8171..9271
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 3.2e-33.
                     Score: 107.0. Matches aSDomain:
                     nrpspksdomains_ctg12_29_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 79.4; E-value:
                     4.2e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_29"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-29, bitscore:
                     97.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLLVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAVLKY"
     aSDomain        8261..9049
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg12_29_Aminotran_5.1"
                     /evalue="3.20E-33"
                     /label="ctg12_29_Aminotran_5.1"
                     /locus_tag="ctg12_29"
                     /protein_end="293"
                     /protein_start="30"
                     /score="107.0"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLLVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             9291..10784
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_30"
                     /sec_met_domain="Polysacc_synt (E-value: 1.7e-09, bitscore:
                     32.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKKNVVKWNFVFYLLEFLYTILVGIILVPLYLKYIPKDLYGFW
                     LATGNILSILTLINPGFSDVIQQKVAYCYGLHDYKKIGLYTVSGICLTFVFSLIVLIIG
                     VVVNLLIGSIFTMQANYLYELKIAFGLMLVGTFLTINYYSFSSILYAFLSSKSIGLIVL
                     LGNSLGTLISIYLIIHGYGLIALGIASVVRGGVFLSCSVGYVIFKFRKKKIKIVFDLNN
                     VKEIFSFSIYNFLGKTGQTLLTNMNSFLTAKFVSPIDAANLRFTQTVPEFGKVLVLRFL
                     YSVAPIIPNLLAAKGLESIRIKLLNIVYFLISFIFLVCIGFYLLNEQFIYLWLGENNFS
                     GKIINFFIIILLFFSSINKVCFQFLFALGDIKKSNKILFYQSLLYLPIAVFTTKFCGII
                     GLLLSGILVELLALFIFFFPKMVDILNISKIDIRKKLFVELTKISFVTVITLLIGSCVK
                     FSNPSWLLFFVEIVFIVLTFFVLLFLCSKTFRNLLSICK"
     CDS             10788..11933
                     /locus_tag="ctg12_31"
                     /transl_table=11
                     /translation="MKILLVFIDMIRVDHLSLYNDNMEKTSLDLFFENLGGTILTNCYT
                     PAPDTPRSIACLQSGLLPYLNGCDSRVKWPRYFMKPNIETIFDIAVGLGYKVNLCATKS
                     DIETGLFKFKENENISIFTTIEDFTDTVHLSENTLSLIAIDDYHSAIDDYGGTSLGIKE
                     GQKVILYSLNNFLTPDIVNKYDYSFFFSDHGHALQSEIVMQKNKLELLSDGRTKLFMFY
                     HNINNKKIVKDSRLASILDLYASIVDLIGSGDFRQGFSFFRDSQRDILHIEDHADFRVS
                     PEQIVSQWRVISDEIDIRTNVFETLNKKGQIIDINVVKKYLDSFSPSFSYYMKQIEILK
                     MYEKMKQRKTHYFNGVKRANWWIRCYVRIINRLYILINRLK"
     CDS             11930..12799
                     /locus_tag="ctg12_32"
                     /transl_table=11
                     /translation="MIVSSLRGGLGNQMFIYAMVKAMALRNNVPFAFNLTTDFANDEVY
                     KRKLLLSYFALDLPENKKLTFDFSYGNYYRRLSRNLGCHILHPSYRYICEERPPHFESR
                     LISSKITNAFLEGYWQSEKYFLDYKQEIKEDFVIQKKLEYTSYLELEEIKLLDKNAIMI
                     GVRRYQESDVAPGGVLEDDYYKCAMDIMASKVTSPVFFCFSQDLEWVEKHLAGKYPVRL
                     ISKKEDDSGTIDDMFLMMHFRNYIISNSSFYWWGAWLSKYDDKLVIAPGNFINKDSVPE
                     SWFKLNVR"
     CDS             12807..13859
                     /NRPS_PKS="Domain: NAD_binding_4 (4-199). E-value: 6.3e-12.
                     Score: 37.0. Matches aSDomain:
                     nrpspksdomains_ctg12_33_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     300.8; E-value: 2.1e-91)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_33"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.6e-16, bitscore:
                     53.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 5.6e-13,
                     bitscore: 43.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVLVTGAAGFIGSHVCKRLLQRGDEVVGLDNINSYYDINLKYGR
                     LSSLGVPQSELSWYKFTRSNVYPRFSFVRMNLEDRQAMQMLFANGNFDVVINLAAQAGV
                     RYSIENPYAYVESNIDGFLNVLEGCRHSQVKHLVYASSSSVYGLNGQVPFSEKDGIAHP
                     VSLYAATKKSNELMAHTYSHLYNIPSTGLRFFTVYGPWGRPDMSPFLFADAILHGRPIK
                     VFNNGNMLRDFTYIDDIVEGVLRVADSIPEGNQCWDAEVADPSMSCAPYKIYNIGNSRP
                     VKLMDFIRAIEMSIGREADKIYLPMQPGDVYQTYADTSSLSREIGFQPNTSLEAGVKKT
                     ISWYKEFYNL"
     CDS_motif       12816..12878
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg12_33_0001"
                     /evalue="2.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg12_33"
                     /protein_end="24"
                     /protein_start="3"
                     /score="13.9"
                     /tool="antismash"
                     /translation="LVTGAAGFIGSHVCKRLLQRG"
     aSDomain        12819..13403
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg12_33_NAD_binding_4.1"
                     /evalue="6.30E-12"
                     /label="ctg12_33_NAD_binding_4.1"
                     /locus_tag="ctg12_33"
                     /protein_end="199"
                     /protein_start="4"
                     /score="37.0"
                     /tool="antismash"
                     /translation="VTGAAGFIGSHVCKRLLQRGDEVVGLDNINSYYDINLKYGRLSSL
                     GVPQSELSWYKFTRSNVYPRFSFVRMNLEDRQAMQMLFANGNFDVVINLAAQAGVRYSI
                     ENPYAYVESNIDGFLNVLEGCRHSQVKHLVYASSSSVYGLNGQVPFSEKDGIAHPVSLY
                     AATKKSNELMAHTYSHLYNIPSTGLRFFTVYG"
ORIGIN
        1 tgttggcagg aagaaagacc gcattgtgta tttgcaatgt gcacctctgc tcaatgatga
       61 ttttcaagtg gagcaaatgt acaacacgct ggagatgata caagacaatt atgaaaagtg
      121 ggtcgtttct atggacgata ccacattgcc ctccaaagaa gggattcgtc acatacaagt
      181 ctggcaactg cctgaaatac tatagtctga caatcttttt tgattgcttt gatgtccgga
      241 tgatgccgtt tacgaagtta acatcttgtt gtttacgaag ttaatatcat aattttacga
      301 agttaaaatc gtatcttcgg gaagttaact tcctgaagtc acgattttaa cttcgtatta
      361 gtgctttttg aatcgctttt caatcccttg agaatcagtg cccgtttccg gaggaaaaca
      421 gctgcgttct ttaattgact gcaagcaaac agtattttcc agaatataaa aatgtactgt
      481 ttgtcagaaa agttcttttt aggttccgct tcttttcttt gcccggttca acgctgcgat
      541 catgtatttt ccttttgctc cgatgttact ccagttcgtg ctgcaaatca gtttccatac
      601 aggggttcct tttctcccgt aatctgacag tcgcaggatt gcttcgatct ctttttcgtc
      661 tgttattccg aatcgttcca ggtttcccat taatcccacg tagttgtgtg tcattgtatt
      721 aaatgcgtat ccgggcatac tgaccggcgt agcattgact tcctcttcct tcccccttgg
      781 gggagctgag gggggaaatt ctctactttg ctttacttta ctttgttcgg tattgcatgc
      841 attttttgca tcagagcctg catcctgctc tacattttgc gtgcagacgg tcttttcttc
      901 attacatgtc tctttcggtt ttatcagtag ataaggcatg gctgtccagt tcctctttct
      961 tcgcttggtt gcctctatcc atactttttg tattgcttca gaggtcagta ctttatgttc
     1021 cgcatagctt cccctgtcta tcattccttt ctcgatcatt atcttgataa tcccctgcac
     1081 ctcttctgcg tctgcctctt ttcccgtctt gttggcgaaa ataaggcatt gttcctcacc
     1141 ccacggaata taatatcctt ctttatatat tttgcatagg agtttcagta caatcgcgag
     1201 tcctttcatg ccatattttg cttctattac ctccattgcg ttctcttcca taaaattcac
     1261 agctattgga aagtaattta ttccatcgta tgttgttgcc ataattgtta agttgttatg
     1321 ttactgatta attggtcact gaaagattct cctatacgat cgctctccat tccatgaaat
     1381 tctctatttt gaaggtcatc cacctttgtt gctccacatc ccggtagacc actgtgtttt
     1441 ttatttccat cggatcatac tgctttccga aatctttttc gtatcccacc aatgttcctt
     1501 tcaccagttt gaatgttccg tcctgtttca tataagctac ggctgcatgt ccatattgca
     1561 tatattctat gagggcttcc agtcgttctg ccatccattc ggagcactgt tctgtgtagt
     1621 ccttttcgag catgatttgt cttttccatt ttcctttcat catttcgttt ttcgatactg
     1681 ctttcctgtt ctttttcata attgattttt taaagtttat taatgagtta ttgtcgggct
     1741 tttattttta cccatggcaa agtacggtaa taagttttga atagactaat cctgtaaaag
     1801 tactttagaa aggggctttt acaggatttt aacaatcggt tattcgcttt catctcgctt
     1861 tttccggaat gctctggcat attttttcag ctctgataga aaagaacgtt tattaggctc
     1921 tgtagcaatg cctttgcgct gatattcaaa ggtgagatat tcttttattg tttcctgtag
     1981 ttcttcaatg ggtctgtttt ccatgctgtt gattccgcct ttgataaagc tttcggtaag
     2041 tgcctccatt agctttcctt tgccttttgt gatgcgtagt ggttctctaa ccttttgatt
     2101 gaggctgaat tgcaagtcag ctttacccgc aaagattact tttccattta cttcgatggt
     2161 tactaagtta tcattcaatg agataactac tttttttctt ccataatgtt agttattaaa
     2221 tgaatttatg aaaggacaaa gtttgtataa aaaaatataa atataaaaga ataccggaat
     2281 ttttttagtt taaagggaaa atcttgaagt gtaaggatct tgttattagt tatttatctt
     2341 aagatatagg tgttgtttca aaaaacgttc gtttgattga acaaaggtaa ggagtctgtt
     2401 ttaatgtaca aaatatttag tggataaaat tttatcaaag attttatatt gttgattttc
     2461 aaacacatat agagcaaaaa aagttctctg ctcagcaact ttacaatatt cattttttca
     2521 tcgaaaaaaa ctcaaaaaat gctgtttcaa aagacgaacg ttttttgaaa cacattcgtt
     2581 cgttctcaac ttctaaaaat gtttcgtaaa atttgacggt ttgaaagaga aaagatgtct
     2641 cgttcaaacc gcgaagcgca cccgaaacaa aggaaaattt ccccaagtat aaatcgtaaa
     2701 tgtctgaaca acagaagtat tggtttgccg cccgtacccg agataaacaa gagtttgcta
     2761 ttcgtgactc tcttgaaaaa ttgaagactg aacttgatct caattactat cttcccactc
     2821 agtttgtcat ccggcagttg aaatatcgtc gaaaacgggt ggaagtccct gttattaaga
     2881 atcttatctt catccaagct accaagcaag atgcttgtga tatttctaat aaatacaata
     2941 tccagctttt ttatatgaaa gacctgctta ccagggccat gctgatagtt cctgataaac
     3001 agatgcagga cttcatattt gtcatggatt tagatccgaa tggcgtcagt ttcgataatg
     3061 accatttatc tgttggtagc agggttcagg tagttaaagg tgatttctgt ggtgtcgagg
     3121 gcgaacttgc cagcgaggcc aacaaaactt atgttgttat tcgtattgcc ggtgtattga
     3181 gcgccagcgt caaagttcct aaaagttatt tacgtgtcat ttaagttatg aatacactca
     3241 cttctcaaat tgaacaatta cagagtctcg cgcacgagtt actctattta ggtgtggatg
     3301 gtgctcctat ttataccgat catttccgtc agttgaacaa agaagtttta gaacaatccg
     3361 atgcgttgta tcctcagcgt ggtgctactc ccgaagagga agcaaacatc tgtctggcat
     3421 tattgatggg ttacaatgca accatctata atcagggtga caaggaggag aaaaagcaag
     3481 ttgttctcaa tcgttgttgg gacgtgcttg accaacttcc tgctacttta ttgaaatgcc
     3541 agttgttgac ttattgttat ggtgaggtgt ttgaagagga gttggcgaaa gaggcgcata
     3601 ctatcataga aagttggagc aatcgagaac ttttaaaagc tgaaaaagaa atagctgaaa
     3661 gtttgaataa tttggaagct aatccttatc cgtacagcga actacacgaa tgattcgttc
     3721 ctttctttcc cgttctcccc tttacgtttt ggctctctat gccagcgttt tgatttttct
     3781 ggtttatact tgtgcctatg cctaccgtaa gccatttacc gcagccattt atgaaggtga
     3841 gattctttgg ggattcgatg tcaaaatcct gtatgtcctt tctgagatta tcggctacgc
     3901 cctttccaag ttcatcggtg ttcgtattct gccttcgatg aaagcgggtc accgcatcta
     3961 ttatataata gggctgctta ctttttccga agttgctttg ttgggttttg cacttcttcc
     4021 ggttcctttg aaggtgtgtt ctatttttct gagcggtctt cccctgggta tgatctgggg
     4081 tgtcattttt agctatatcg aagggcgtcg tatcagtgaa atattgaatg tcgggctgag
     4141 cgttgctttg atagtctctt ccggtttggt gaaaaccttg ggacaattcg tgatggataa
     4201 tttgcatgtg tcggaatatt ggatgccttt taccaccggt ttgttggtat accctgttat
     4261 gttgctttgc agctggcttc tcaatcagat tccggctccc aatgagcaag atatcataca
     4321 gcgtaccaaa cgtgctccga tggatggtaa agacaggcgt aaatttttga ggcaattctt
     4381 ctggggaatc tgcatgctgg ttgtttttta cggtgccctg accgtgttcc gtgagcttcg
     4441 tgactctttc gctgccgata tttggaagga gctccatatt gagggtgcaa tgatctttac
     4501 tcagacagag gttcccattg ccgtttttgt ccttgtactg atgttcctga ttgtgtttgt
     4561 ccgtaataac cgtttggctc ttaatatcat ttattgcatt gccgtcacag gcggttcctt
     4621 aatggttttt tccacattgc tttatgtgta cggttttctt tctcctattt ggtggatgat
     4681 tctttccggt cttggtctgt atatggggta tattcctttc acttacctga tagaacgtct
     4741 gattgcttcc cttagggtgg ttagtacggc tgtttttatt atttatttgg ccgattcttt
     4801 cggctatctg ggcactacgg gtgtgtttat ggtcaagaac ttcgtttctg ctgatatttc
     4861 ctggactgtc atgctgatgc gtactgccct tttttcagga tttgtttctg tcctgtcgat
     4921 ttttgcgatt tactgttatt tcaagcaaca attgaattca cttatattaa ttccctctga
     4981 aattcatgat taaaacagca atgatcatgg ctgccggtct tggtacccgc ttcgggcatt
     5041 ataccgagct tgtgcccaaa ggttttgtgg aggttggtgg aaaacctatg attatccgct
     5101 ctatcgaaac ccttctttcc tgcggtatcg aacgtatcat cctcggtacg ggttataaaa
     5161 aagaggctta tgaggccctt caggcggatt tcccccagat agagacctgt ttcagtcccc
     5221 gttatgccga tactaacagt atgtacactc tgtacaatac gcgtgacgtg ataggcgatg
     5281 acagtttcct gctgcttgaa tcggaccttg tttttgaacg caaggccatc ctttcgctgc
     5341 tggatgacga attcccggat gtgatgcttg tctcttctct gaccaagttc caggatcagt
     5401 attatgtgga atatgaccgc aatcacatcc ttacttcctg ttcggtagac aagaacgccc
     5461 ttgaggcaaa aggcgagctg gtcggtatcc ataaactttc caatactttc taccgccgga
     5521 tgtgcgccga ttatgcgacc atcctggagt cccagcctaa actgggttac gaatacgaac
     5581 tgctccgcat gtcccgttcc gtttcccctg tccgtgtgct cagggtggag ggtcttaaat
     5641 ggtatgaaat cgatgatgaa gccgaccttt cgtatgccga ggagcacatc atccgctatt
     5701 gttaaaaaca aatcttttcc atatatgaac aagaaaatct atgtcggtat gaccgcggat
     5761 atcatgcatc cggggctgat ccatattatt catgaagcta ctaaatacgg tgatgtcatc
     5821 gtcggtctgc tgacggacaa ggccatcgcc gaacacaaac gcctccctta ccttacctat
     5881 gatcagcgta aggaggttgt tgagaatatc aagggggttt gcgaagttgt tccccaggag
     5941 gattggagct atgttccgaa tctggaaaaa ctcaagcctg actatatcat ccacggtgac
     6001 gactggaaaa cgggtccgtt gcgcgaggtg cgcgaacagg tttttgaggt gatgaacgcc
     6061 caggggggca aggtaatcga gatcccttat acccggggca tcaactcctc ctcgctcgac
     6121 aaggatatca aggcgatcgg gactacccct gacgtacgtc ttaagtccct ccgccgcctg
     6181 atccaggcca agcctgtggt ccgtatcctg gaggctcacg acggtctttg cggtctgatt
     6241 attgagaatc ttgaagtcca gaagggtgat aagcgcgagg tctttgacgg catgtggtcc
     6301 agcagcctga ccgactccac gagtaagggt aaaccggata ttgaagcggt cgaccttacc
     6361 acccgtttac aggacctgaa caatatcctt gaatgtacca ccaagcctat tatttttgat
     6421 ggagacacgg gtggcaagat cgaacacttt gtctttactg tgcgcactct ggaacgtcat
     6481 ggcatttctg cggtaatcat tgaagataaa gtcggtctga agaagaattc cctttttggt
     6541 actgacgcta tccagactca ggatagtatc gagggtttct gcgataagat cagagcaggg
     6601 aagaatgccc aggtcaccgg tgactttatg atcattgcgc gtatcgaaag ccttattgcc
     6661 ggcaaaccca tgagtgacgc cctcgaacgt gcttatgcct atgtacaggc gggtgcggac
     6721 ggcatcatga tccacagcaa ggataagtcg ggtgaggata tccgtgagtt ctgccggact
     6781 ttccgcaaag aatacgccca tgttcccatt gtcgttgttc cgacgactta tgaccatgtg
     6841 cacgaatccg aacttcacga atggggtgcc aacgtagtca tttacgccaa ccaccttctc
     6901 cgtgccgctt acccggccat gatgaacgtg gccaggacca tccttgaaaa cgagcgcgcc
     6961 gaggaggtcc gtccgctttg tatgcctatc aaggaaattc tggaattgat tccgggcact
     7021 aaataaatca gacggttatg gtaagtgtag aaaagatata cgatacgttc cttcatcacg
     7081 gtgttgactt ctttacgggt gttcccgatt cccttttgaa gaatatttgc gcctatatca
     7141 cggatcatgc tccgcgtggt aagcatatca tcgccgccaa tgaaggttcc gcggtgggca
     7201 ttgcctgcgg ttattatatg gcttctggca acgttccttt ggtttatatg cagaactccg
     7261 gtctgggaaa tacggtgaat cccctcttgt cccttgcgga cgagaaagtg tacagccttc
     7321 ctcttctttt gctggtcggc tggcgcggtg agcccggcac aaaagacgaa ccccagcata
     7381 agaagcaggg cgaggttacc cttgatcttc tgaaagccat gaaaattcct tttataattc
     7441 tggatacgga tgaagacgag gccctggcgc agatccatga cgcggttgtc tcggcgaaga
     7501 gccggtcgat tccccatgcg attgtcatcc gtaaagatac gtttggaaaa tataaattgc
     7561 gtcaggaagc cttgaatgac tatcctctgt cccgcgagga ggcgctaatg caggttgtcg
     7621 accacctcgg ggacaatgac attgtggttt ccaccacggg caagctctcc cgtgagcttt
     7681 tcgagtaccg tgaatcgaaa gggcaggggc acgcaaggga tttcctaact gtgggttcca
     7741 tgggtcacag ttcttccatt gccctgggga ttgcccttga gaagcctgac cgccgtgtct
     7801 actgtcttga cggtgacggt gcctttatca tgcacatggg tgctgtcagc aatatcggcg
     7861 atctttctcc caagaattac aggcacgtcc ttttcaacaa tggtgcccat gaatctgtcg
     7921 gcggtcaacc cacgctcggt ttccgtctgg atatcgcctc gatagcgaaa ggttgcggtt
     7981 atgcgcatgt actgactgcc tccgacaagg aagggctttc gtgtgcgctt gagaagctgt
     8041 ccggcctgtc cggcccggtt cttcttgaaa ttaaggtccg gatcgattca cgtgatgatc
     8101 tgggtcgccc tacgactact ccggtagaga ataaagagca ttttatggca tttttaaaag
     8161 atacgcattc atgaatatcg aaagaaagat ccttttgaat ccgggtcccg ccaccacgac
     8221 ggatacggta aagctggcgc aggttgttcc cgatatctgt ccgcgtgaga aagagtttgc
     8281 gggtatgatg aaacagttac gtgacgacct ggtccgcgtt gcgcatggag acctctccaa
     8341 acatacggcc gtcctgtttt gcggctcggg tacgatcaat atcgatatct gcctgaactc
     8401 tcttcttcct gcggataaga aagttctggt tgtcaataac ggtgcctata gcacccgtgc
     8461 ggtggaagtc tgcgaatatt acggtcttcc ccatatcgat ttgaagtttt ccgtttacga
     8521 acttcccgac ctgttggtaa tcgaaaagac gctttccgac aatccggaca tcgctttggt
     8581 ctataccacg caccatgaaa cgggtacggg tatcttgaac cccatccgtg agatcggaaa
     8641 aatagcccat tcgcacggtg ccgtttttgt tgtcgacacc acttcctccc tgggtatgat
     8701 tccttttgat atcgggaagg ataatgttga cttttgtatg gcttcggctc agaaaggcct
     8761 tcaggccatg acgggtcttt cctttatcat aggtgatgaa tccctgatac gtgcttcaag
     8821 ggattatccg aaacgctcct actattgtaa cctctattta caatacgatt actttgagaa
     8881 gacgggtgag atgcatttta ctcctcctgt tcaaaccgtt tacgctgccc gtcaggctct
     8941 tgatgaatat tttgcagtag gtgaagaggc taaattcgcc cgtcacaaga gggtctttga
     9001 agccatccat aaaggtttgc aagagcttgg tcttcagtat gcgatcaaac gtgaatggca
     9061 gtcgggtctt gttgtttctg tattgtatcc tgatgatccc ctctgggatt ttgataaggt
     9121 tcatgattac tgctatgaac gtggctttac gatctacccg ggtaagattt ccacaacgaa
     9181 tacattccgg ctttgtgcgt tgggagagat tgatgtggag gatattgaga ggttctttga
     9241 ggtgatgagg gaggctgttt taaaatacta gagaaattgt caattgggat atgaaagata
     9301 aaaaaaatgt agtaaaatgg aattttgtat tttatctctt ggaatttttg tatacaattt
     9361 tagttgggat tattttggtt ccgttgtatt tgaaatatat tccaaaggat ttatatggtt
     9421 tctggctagc tactggtaat atattgtcta ttttaactct tatcaatcct gggttttcag
     9481 atgtgataca acaaaaagtt gcatattgtt atggattaca tgattataaa aaaataggat
     9541 tatataccgt ttcaggtatt tgtcttacgt ttgttttttc attaattgtt ttgataatcg
     9601 gagtagtagt taacctttta ataggtagta tatttacaat gcaagctaat tatttatatg
     9661 aattaaaaat agcttttggc ttaatgcttg ttggtacatt tttaactatt aattattatt
     9721 ccttttcttc tatattatat gcttttctta gtagtaagtc aatcgggcta attgtacttc
     9781 taggcaatag tttaggtact ttaatatcta tttatcttat tatccatgga tatggtctaa
     9841 tagctttggg aattgcatca gttgttcgag gaggtgtttt tttgtcatgt agtgttggct
     9901 atgtaatatt taaatttcga aaaaagaaaa taaaaattgt atttgattta aataatgtta
     9961 aggagatctt ttctttttct atatataatt ttttaggtaa aacaggacaa acattgttga
    10021 ctaatatgaa ttctttcttg actgctaagt ttgtttctcc tattgacgct gcaaatttga
    10081 gatttactca aactgtgccg gaatttggta aagttttagt tttaagattt ttatattctg
    10141 ttgctcctat tattcctaat ttgttagcag ctaaggggtt ggagtctatt agaataaagc
    10201 ttttgaatat tgtgtatttt ttgatttcct ttattttctt agtatgtatt ggtttttatc
    10261 tattgaatga acaatttata tatttatggc ttggtgagaa caatttttca gggaaaataa
    10321 ttaatttttt tatcattatt ttattgtttt tttcttctat aaacaaggtc tgttttcagt
    10381 ttctttttgc attaggagat ataaagaaaa gcaataagat tttattttac caatctttgt
    10441 tgtatttacc tattgctgtt tttacaacga aattttgtgg aataattggt ttattgttat
    10501 ctggaatatt agtagaatta ttggcactat tcattttctt ctttcctaaa atggttgata
    10561 ttcttaatat ttcgaaaata gatattagaa agaaactttt tgtggagtta accaaaatat
    10621 cttttgttac ggttattaca ttattaatag gttcttgtgt caagttctct aatcctagtt
    10681 ggctactttt ctttgtggaa attgttttta ttgtattaac attttttgtt ttgttgtttt
    10741 tatgttcaaa gacttttcgt aatttattgt ctatttgtaa ataaaagatg aagatactac
    10801 tagtttttat agatatgata cgtgttgatc atttatcatt atataatgat aacatggaga
    10861 aaacatcgtt ggatttgttt tttgaaaatt taggaggtac aattctaact aactgttata
    10921 cacctgcacc tgatactcca agaagtatag cttgtttgca aagtggccta ttaccctatt
    10981 tgaatggctg cgatagtcgt gtcaaatggc caagatattt tatgaaacct aatatagaaa
    11041 ctatttttga tattgcagta gggttaggat ataaagtaaa tttgtgtgcg actaaatctg
    11101 atattgaaac agggttgttt aagtttaaag aaaatgaaaa tattagtata tttactacta
    11161 ttgaagattt tactgatact gttcatttgt cagaaaatac attgtcctta attgccattg
    11221 atgattatca ttctgccatt gatgattatg gaggaacctc attgggaatt aaagaagggc
    11281 agaaagtgat attatattct ttaaataatt ttctaactcc agatatcgta aataaatacg
    11341 actattcgtt tttcttttca gaccatgggc atgctttgca gagtgaaatt gtcatgcaaa
    11401 aaaataaact agaactactt agtgatggaa gaactaaact ttttatgttc tatcataata
    11461 ttaataataa gaaaatagta aaagattcta ggcttgcttc tattttggat ctttatgcct
    11521 ctattgttga tttgattggt agtggagatt ttaggcaagg tttttccttt tttagagaca
    11581 gtcaaagaga tatacttcat atagaggacc atgctgattt tagggtgtct ccagagcaaa
    11641 ttgtgagtca atggcgagta atttcagatg aaatagatat taggactaat gtatttgaaa
    11701 ctttaaataa aaaaggacaa ataatcgata taaatgtggt aaaaaaatat ttagatagtt
    11761 tttccccctc gttttcttat tatatgaaac agatagagat tctaaaaatg tatgagaaaa
    11821 tgaaacaacg gaaaacgcat tattttaatg gggtaaagcg agctaattgg tggatccgct
    11881 gttatgttag aattataaat aggttatata tactaataaa tagattgaaa tgattgtatc
    11941 atctttgcga ggaggattgg ggaatcaaat gtttatttac gctatggtga aggccatggc
    12001 attaagaaac aatgtaccat tcgcttttaa tttgactact gattttgcaa atgatgaagt
    12061 ttataaaagg aaacttttat tatcatattt tgcattagac ttgcctgaaa ataaaaaatt
    12121 aacatttgat ttttcatatg ggaattatta tagaaggcta agtcgtaatt taggttgtca
    12181 tatacttcat ccatcatatc gttatatttg cgaagagcgc cctccccact ttgaatcaag
    12241 gttaattagt tctaagatta caaatgcttt tctggaagga tattggcagt cagaaaaata
    12301 ttttcttgat tataaacaag agataaaaga ggactttgta atacaaaaaa aattagaata
    12361 cacatcgtat ttggaattgg aagaaataaa attgctagat aagaatgcca taatgattgg
    12421 ggttagacgg tatcaggaaa gtgatgtagc tcctggtgga gtgttagaag atgattacta
    12481 taaatgtgct atggatatta tggcatcaaa agttacttct cctgttttct tttgtttttc
    12541 acaagattta gaatgggttg aaaaacatct agcgggaaaa tatcctgttc gtttgataag
    12601 taaaaaggag gatgatagtg gtactataga tgatatgttt ctaatgatgc attttcgtaa
    12661 ttatataata tcgaatagct ctttttactg gtggggagca tggctttcga aatatgatga
    12721 taagctggtg attgctccag gtaattttat aaataaggat tctgtaccag aatcttggtt
    12781 taaattgaat gtaagataaa atcttaatga atgtattagt aaccggtgct gccggattta
    12841 taggttcgca tgtttgtaag cgtcttttgc aacgtgggga tgaagttgtg ggcttggata
    12901 atattaattc gtattatgat attaatttaa agtatggacg cctttcgagc ttaggtgttc
    12961 ctcaatctga actgtcatgg tataagttca cacggagtaa tgtttatcct cgatttagtt
    13021 ttgtgcggat gaacctcgag gataggcagg ctatgcaaat gctgtttgct aatggaaatt
    13081 ttgatgtagt aatcaatttg gccgcacaag cgggagtgcg ctactccatt gagaatccat
    13141 atgcttatgt tgaaagtaat atagacggtt ttctgaatgt tctcgagggt tgtcgtcaca
    13201 gtcaggtgaa acatttggtt tatgccagtt ccagtagtgt atatggtttg aatggacagg
    13261 ttcctttttc agagaaagat ggcatagccc atccggtgag tctgtatgcc gcaaccaaga
    13321 agtcgaatga acttatggca catacttata gccatttata taatatacct tctacgggtc
    13381 ttcgtttctt cacggtatat ggtccctggg gtagaccgga tatgtctcct tttctatttg
    13441 cggatgctat cttgcatggt cgccccatca aggtctttaa caatggcaac atgcttcgtg
    13501 attttacata tatagatgac attgtggaag gtgtcttgag agtggctgat tctattccgg
    13561 aagggaatca gtgctgggat gctgaggttg cggatccaag catgtcctgt gctccctata
    13621 agatttataa tattggtaat tcccgtcctg taaaattgat ggattttata cgtgctatag
    13681 aaatgtcaat cgggagggaa gctgacaaga tctatcttcc gatgcagccc ggggatgtgt
    13741 atcagaccta tgcggatact tcttctcttt cgcgggaaat tggttttcaa cccaatacgt
    13801 ccttggaggc gggcgttaag aaaacaataa gttggtataa agaattttat aatctataat
    13861 tatgaagatt gctatagttg gtacaggtta cgtcggtttg gttacaggta cctgtttctc
    13921 tgagatggga gtagacgtca catgcgttga tgtgattgaa tctaaaattg ataatcttaa
    13981 aaaaggcata attccgatct atgagccggg acttgaagac atggtgcacc gcaattacaa
    14041 tgcggggcgt ttgaagttca ctacttcctt agcctcatgt ttgaatgatg ttgaggttgt
    14101 gtttagtgca gttggtactc ctcctgatga agatggcagt gcggatttaa agtatgtgct
    14161 tgaagttgcc cgtacgattg gtaaaacgat gaaccattat gtactggtgg taacgaagag
    14221 tactgttcct gtcggcacag cgcaacaggt gaaagctacg atccggggtg a
//
