LOCUS       gnlProkkaIBPKALHF_43   13063 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IBPKALHF_43.
ACCESSION   gnlProkkaIBPKALHF_43
VERSION     gnlProkkaIBPKALHF_43
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 11:33:01
            Original ID  :: gnl|Prokka|IBPKALHF_43
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13063
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13063
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3768:8063]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3769..8063
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13063
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13063
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(2..85)
                     /locus_tag="ctg43_1"
                     /transl_table=11
                     /translation="MATTYDGINYFPIAVNFMEENAMEVIEA"
     CDS             complement(135..482)
                     /locus_tag="ctg43_2"
                     /transl_table=11
                     /translation="MKKNRKAVSKNEMMKGKWKRQIMLEKDYTEQCSEWMAERLEALIE
                     YMQYGHAAVAYMKQDGTFKLVKGTLVGYEKDFGKQYDPMEIKNTVVYRDVEQQRWMTFK
                     IENFMEWRAIV"
     CDS             complement(623..961)
                     /locus_tag="ctg43_3"
                     /transl_table=11
                     /translation="MNDNLVTIEVNGKVIFAGKADLQFSLNQKVREPLRITKGKGKLME
                     ALTESFIKGGINSMENRPIEELQETIKEYLTFEYQRKGIATEPNKRSFLSELKKYARAF
                     RKKRDESE"
     CDS             1483..2007
                     /locus_tag="ctg43_4"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             2011..2496
                     /locus_tag="ctg43_5"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             2493..3776
                     /locus_tag="ctg43_6"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAAFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             3769..4488
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.5; E-value:
                     4e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_7"
                     /sec_met_domain="NTP_transf_3 (E-value: 2e-15, bitscore:
                     49.0, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKTAMIMAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLS
                     CGIERIILGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDNFLLL
                     ESDLVFERKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKG
                     ELVGIHKLSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEI
                     DDEADLSYAEEHIIRYC"
     CDS             4436..5809
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 213.9;
                     E-value: 4.6e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_8"
                     /sec_met_domain="CTP_transf_like (E-value: 1.2e-12,
                     bitscore: 39.7, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 4.7e-122, bitscore:
                     398.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.3e-64, bitscore:
                     208.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKPTFRMPRSTSSAIVKNKSFPYMNKKIYVGMTADIMHPGLIHI
                     IHEATKYGDVIVGLLTDKAIAEHKRLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNL
                     EKLKPDYIIHGDDWKTGPLREVREQVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIG
                     TTPDVRLKSLRRLIQAKPVVRILEAHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDS
                     TSKGKPDIEAVDLTTRLQDLNNILECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAV
                     IIEDKVGLKKNSLFGTDAIQTQDSIEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPM
                     SDALERAYAYVQAGADGIMIHSKDKSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHES
                     ELHEWGANVVIYANHLLRAAYPAMMNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             5821..6957
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_9"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6.5e-22, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.1e-20, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             6954..8063
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 4.5e-34.
                     Score: 109.8. Matches aSDomain:
                     nrpspksdomains_ctg43_10_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 81.8; E-value:
                     7.7e-25)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_10"
                     /sec_met_domain="Aminotran_5 (E-value: 3.1e-31, bitscore:
                     100.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKALSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMKSVNTVLVNK"
     aSDomain        7044..7832
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg43_10_Aminotran_5.1"
                     /evalue="4.50E-34"
                     /label="ctg43_10_Aminotran_5.1"
                     /locus_tag="ctg43_10"
                     /protein_end="293"
                     /protein_start="30"
                     /score="109.8"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKALSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             8076..8894
                     /locus_tag="ctg43_11"
                     /transl_table=11
                     /translation="MLKKRLDYSQLKVIQLNILKDVDAFCRENNITYYLTYGTLLGAVR
                     HQGYIPWDDDIDIAMPRKDYEKFLSNYNLNGSKKNVYQVVAIELNNAYPYPFGKVQDLS
                     TVLLEYSDINYPLGINIDIFPIDGLPVDLKKSDKHFLKIKWLMMIMNLKKVKITIKRSF
                     LKNLILLIGKILTLLIPYRFIVCKMSYIAQRYDYEKSDYVSNLSCPDGKHERTSKRVFE
                     NSIEILFEGNNFYAPIGYHEWLHNIYGDYMKMPPVPERVSHHKFEIYKIL"
     CDS             8897..9892
                     /locus_tag="ctg43_12"
                     /transl_table=11
                     /translation="MCSKDNFLQEVRALCIFTVILLHVPFQGHDNISFNTWLMSKQLIT
                     FPVAVFFFLSGYFYSFRNYKSRIVKLLCPFLFWNMSVHLIKFIRGESGFNIENFLLGNG
                     LPYYYLAVLLQIVLFHYIIFKYWSEMVYRVLSISISIISLMAYYYFSISYSIHFNCYLY
                     FPFWILFYTLGTFGKKYWRNLISKIPFCVILLFILISVFLMFFEANLMYYILFQEGIAG
                     SQVKFSSWVYSILIVLLLLKIDYSIDENVTRNFGTLIGDYSYGVYLIHIFILSLIYKLC
                     IVVFNDNYNVLLPFIAASITLVISVFMIYILNKCLPPFILKFLGLYVKSN"
     CDS             9876..11048
                     /locus_tag="ctg43_13"
                     /transl_table=11
                     /translation="MLKVTDECTACGACLSICPKNCISFKSNEEGFLYPHIDIEKCVDC
                     DLCSKVCFLNDHITPTFRENDISYYAAKAIERCNLSSSGGIFPLLAESVLKNDGVVIGA
                     AWDDKFNVKHILIKSKSELPLLCGSKYIQSNTEKVFKIVKEHLSIQTVLFSGTPCQVKG
                     LKTFLGKDYDNLITVELVCHGVPSPLVFRRYLNGVLKYNNLDISQCSKINFREVKDDIY
                     RFVIYNKTKIPFYEQYTNLYTKTFLQNLFLRNSCYNCKCKLENSVGDFILGDFWGCRDF
                     YPEFYDPKGVSLVIVCTERAKKIWLNLKLSRIEVKKKIVFRSNRHLLKSASYNRNRDLF
                     FKTFIHEAEISLDDILMGYTNKDIWVKVKDLIISVLRFVGLFQLVQLYRK"
     CDS             11045..12103
                     /locus_tag="ctg43_14"
                     /transl_table=11
                     /translation="MKIALLTLPFVNNYGGILQAYALKHFLELRGHSVCIIDRNSNFKI
                     SFIDILRLAKRKFLGNRIRNFAYFKKQYLLPMTSEIITNKEMLLLDEKYQFDIYIVGSD
                     QVWRAIYYRDIKYNFYLDFVSSKRKISFAASFGISSWEYTNTETDIIAKLLMDFSFVSV
                     REDTAVRLCSDYLNINAVQFLDPTFLLDKNEYCCLADCFYSSKKIDIFAYIMGPDSSKD
                     KLIKIISDYSGLSVQSITQSKFSFKKNESIQEWLQNFYKSKFVVTDSFHGLAFSLIFNK
                     PFIVCGFSNRGMGRYESLLRYFSLENRLLYSLEDLKELNLSTIWDINWKEVNAKIAENK
                     RFVLELMQTVGV"
ORIGIN
        1 ttgcttctat tacctccatt gcgttctctt ccataaaatt cacagctatt ggaaagtaat
       61 ttattccatc gtatgttgtt gccataattg ttaagttgtt atgttgctga ttaattggtc
      121 actgaaagat tctcctatac gatcgctctc cattccatga aattctctat tttgaaggtc
      181 atccaccttt gttgctccac atcccggtag accactgtgt tttttatttc catcggatca
      241 tactgctttc cgaaatcttt ttcgtatccc accaatgttc ctttcaccag tttgaatgtt
      301 ccgtcctgtt tcatataagc tacggctgca tgtccatatt gcatatattc tatgagggct
      361 tccagtcgtt ctgccatcca ttcggagcac tgttctgtgt agtccttttc gagcatgatt
      421 tgtcttttcc attttccttt catcatttcg tttttcgata ctgctttcct gttctttttc
      481 ataattgatt ttttaaagtt tattaatgag ttattgtcgg gcttttattt ttacccatgg
      541 caaagtacgg taataagttt tgaatagact aatcctgtaa aagtacttta gaaaggggct
      601 tttacaggat tttaacaatc ggttattcgc tttcatctcg ctttttccgg aatgctctgg
      661 catatttttt cagctctgat agaaaagaac gtttattagg ctctgtagca atgcctttgc
      721 gctgatattc aaaggtgaga tattctttta ttgtttcctg tagttcttca atgggtctgt
      781 tttccatgct gttgattccg cctttgataa agctttcggt aagtgcctcc attagctttc
      841 ctttgccttt tgtgatgcgt agtggttctc taaccttttg attgaggctg aattgcaagt
      901 cggctttacc cgcaaagatt acttttccat ttacttcgat ggttactaag ttatcattca
      961 atgagataac tacttttttt cttccataat gttagttatt aaatgaattt atgaaaggac
     1021 aaagtttgta taaaaaaata taaatataaa agaataccgg agttttttta gtttaaaggg
     1081 agaatcttga agtgtaagga tcttgttatt agttatttat cttaagatat aggtgttgtt
     1141 tcaaaaaacg ttcgtttgat tgaacaaagg taaggagtct gttttaatgt acaaaatatt
     1201 tagtggataa aattttatca aagattttat gttgctgatt ctcaaatata tatagagcaa
     1261 aaaaagttct ttgttcagct actttacaat attcattttt tcatcgaaaa aaaactcaaa
     1321 aatgctgttt caaaagacga acgttttttg aaacacattc gttcgttctc aacttctaaa
     1381 aatgtttcgt aaaatttgac ggtttgaaag agaaaagatg tctcgttcaa accgcgaagc
     1441 gcacccgaaa taaaggaaaa tttccccaag tataaatcgt aaatgtctga acaacagaag
     1501 tattggtttg ccgcccgtac ccgagataaa caagagtttg ctattcgtga ctctcttgaa
     1561 aaattgaaga ctgaacttga tctcaattac tatcttccca ctcagtttgt catccggcag
     1621 ttgaaatatc gtcgaaaacg ggtggaagtc cctgttatta agaatcttat cttcatccaa
     1681 gctaccaagc aagatgcttg tgatatttct aataaataca atatccagct tttttatatg
     1741 aaagacctgc ttaccagggc tatgctgata gttcctgata aacagatgca ggacttcata
     1801 tttgtcatgg atttagatcc gaatggcgtc agtttcgata atgaccattt atctgtcggt
     1861 agcagggttc aggtagttaa aggtgatttc tgtggtgtcg agggcgaact tgccagcgag
     1921 gccaacaaaa cttatgttgt tattcgtatt gccggtgtat tgagcgccag cgtcaaagtt
     1981 cctaaaagtt atttacgtgt catttaagtt atgaatacac tcacttctca aattgaacaa
     2041 ttacagagtc tcgcgcacga gttactctat ttaggtgtgg atggtgctcc tatttatacc
     2101 gatcatttcc gtcagttgaa caaagaagtt ttagaacaat ccgatgcgtt gtatcctcag
     2161 cgtggtgcta ctcccgaaga ggaagcaaac atctgtctgg cattattgat gggttacaat
     2221 gcaaccatct ataatcaggg tgacaaggag gagaaaaagc aagttgttct caatcgttgt
     2281 tgggacgtgc ttgaccaact tcctgctact ttattgaaat gccagttgtt gacttattgt
     2341 tatggtgagg tgtttgaaga ggagttggcg aaagaggcgc atactatcat agaaagttgg
     2401 agcaatcgag aacttttaaa agctgaaaaa gaaatagctg aaagtttgaa taatttggaa
     2461 gctaatccat atccgtacag cgaactacac gaatgattcg ttcctttctt tcccgttctc
     2521 ccctttacgt tttggctctc tatgccagcg ttttgatttt tctggtttat acttgtgcct
     2581 atgcctaccg taagccattt accgcagcca tttatgaagg tgagattctt tggggattcg
     2641 atgtcaaaat cctgtatgtc ctttctgaga ttatcggcta cgccctttcc aagttcatcg
     2701 gtgttcgtat tctgccttcg atgaaagcgg gtcaccgcat ctattatata atagggctgc
     2761 ttactttttc cgaagttgct ttgttgggtt ttgcacttct tccggttcct ttgaaggtgt
     2821 gttctatttt tctgagcggt cttcccctgg gtatgatctg gggtgtcatt tttagctata
     2881 tcgaaggacg tcgtatcagt gaaatattga atgtcgggct gagcgttgct ttgatagtct
     2941 cttccggttt ggtgaaaacc ttgggacaat tcgtgatgga taatttgcat gtgtcggaat
     3001 attggatgcc ttttaccacc ggtttgttgg tataccctgt tatgttgctt tgcagctggc
     3061 ttctcaatca gattccggct cccaatgagc aagatatcat acagcgtacc aaacgtgctc
     3121 cgatggatgg taaagacagg cgtaaatttt tgaggcaatt cttctgggga atctgcatgc
     3181 tggttgtttt ttacggtgcc ctgaccgtgt tccgtgagct tcgtgactct ttcgctgccg
     3241 atatttggaa ggagctccat attgagggtg caatgatctt tactcagaca gaggttccca
     3301 ttgccgcttt tgtccttgta ctgatgttcc tgattgtgtt tgtccgtaat aaccgtttgg
     3361 ctcttaatat catttattgc attgccgtca caggcggttc cttaatggtt ttttccacat
     3421 tgctttatgt gtacggtttt ctttctccta tttggtggat gattctttcc ggtcttggtc
     3481 tgtatatggg gtatattcct ttcacttacc tgatagaacg cctgattgct tcccttaggg
     3541 tggttagtac ggctgttttt attatttatt tggccgattc tttcggctat ctgggcacta
     3601 cgggtgtgtt tatggtcaag aacttcgttt ctgctgacat ttcctggact gtcatgctaa
     3661 tgcgtactgc ccttttttca ggatttgttt ctgtcctgtc gatttttgcg atttactgtt
     3721 atttcaagca acaattgaat tcacttatat taattccctc tgaaattcat gattaaaaca
     3781 gcaatgatca tggctgccgg tcttggtacc cgcttcgggc attataccga gcttgtgccc
     3841 aaaggttttg tggaggttgg tggaaaacct atgattatcc gctctatcga aacccttctt
     3901 tcctgcggta tcgaacgtat catcctcggt acgggttata aaaaagaggc ttatgaagcc
     3961 cttcaggcgg atttccccca gatagagacc tgtttcagtc cccgttatgc cgatactaac
     4021 agtatgtaca ctctgtacaa tacgcgtgac gtgataggcg atgacaattt cctgctgctt
     4081 gaatcggacc ttgtttttga acgcaaggcc atcctctcgc tactggatga cgaattcccg
     4141 gatgtgatgc ttgtctcttc tctgaccaag ttccaggatc agtattatgt ggaatatgac
     4201 cgcaatcaca tccttacttc ctgttcggta gacaagaacg cccttgaggc aaaaggcgag
     4261 ctggtcggta tccataaact ttccaatact ttctaccgcc ggatgtgcgc cgattatgcg
     4321 accatcctgg agtcccagcc taaactgggt tacgagtacg aactgctccg catgtcccgt
     4381 tccgtttccc ctgtccgtgt gctcagggtg gagggtctta aatggtatga aatcgatgat
     4441 gaagccgacc tttcgtatgc cgaggagcac atcatccgct attgttaaaa acaaatcttt
     4501 tccatatatg aacaagaaaa tctatgtcgg tatgaccgcg gatatcatgc atccggggct
     4561 gatccatatt attcatgaag ctactaaata cggtgatgtc atcgtcggtc tgctgacgga
     4621 caaggccatc gccgaacaca aacgcctccc ttaccttacc tatgatcagc gtaaggaggt
     4681 tgttgagaat atcaaggggg tttgcgaggt tgttccccag gaggattgga gctatgttcc
     4741 gaatctggaa aaactcaagc ctgactatat catccacggt gacgactgga aaacgggtcc
     4801 gttgcgcgag gtgcgcgaac aggtttttga ggtgatgaac gcccaggggg gcaaggtaat
     4861 cgagatccct tatacccggg gcatcaactc ctcctcgctc gacaaggata tcaaggcgat
     4921 cgggactacc cctgacgtac gtcttaagtc cctccgccgc ctgatccagg ccaagcctgt
     4981 ggtccgtatc ctggaggctc acgacggtct ttgcggtctg attattgaga atcttgaagt
     5041 ccagaagggt gataagcgcg aggtctttga cggcatgtgg tccagcagcc tgaccgactc
     5101 cacgagtaag ggtaaaccgg atattgaagc ggtcgacctt accacccgtt tacaggacct
     5161 gaacaatatc cttgaatgta ccaccaagcc tattattttt gatggagaca cgggtggcaa
     5221 gatcgaacac tttgtcttta ctgtgcgcac tctggaacgt cacggcattt ctgcggtaat
     5281 cattgaagat aaagtcggtc tgaagaagaa ttcccttttt ggtactgacg ctatccagac
     5341 tcaggatagt atcgagggtt tctgcgataa gatcagagca gggaagaatg cccaggtcac
     5401 cggtgacttt atgatcattg cgcgtatcga aagccttatt gccggcaaac ccatgagtga
     5461 cgccctcgaa cgtgcttatg cctatgtaca ggcgggtgcg gacggcatca tgatccacag
     5521 caaggataag tcgggtgagg atatccgtga gttctgccgg actttccgca aagaatacgc
     5581 ccatgttccc attgtcgttg ttccgacgac ttatgaccat gtgcacgaat ccgaacttca
     5641 cgaatggggt gccaacgtag tcatttacgc caaccacctt ctccgtgccg cttatccggc
     5701 catgatgaac gtggccagga ccatccttga aaacgagcgc gccgaggagg tccgtccgct
     5761 ttgtatgcct atcaaggaaa ttctggaatt gattccgggc actaaataaa tcagacggtt
     5821 atggtaagtg tagaaaagat atacgatacg ttccttcatc acggtgttga cttctttacg
     5881 ggtgttcccg attccctttt gaagaatatt tgcgcctata tcacggatca tgctccgcgt
     5941 ggtaagcata tcatcgccgc taatgaaggt tccgcggtgg gcattgcctg cggttattat
     6001 atggcttctg gcaacgttcc tttggtttat atgcagaact ccggtctggg aaatacggtg
     6061 aatcccctct tgtcccttgc ggacgagaaa gtgtacagcc ttcctcttct tttgctggtc
     6121 ggctggcgcg gtgagcccgg cacaaaagac gaaccccagc ataagaagca gggcgaggtt
     6181 acccttgatc ttctgaaagc catgaaaatt ccttttataa ttctggatac ggatgaagac
     6241 gaggccctgg cgcagatcca tgacgcggtt gtctcggcga agagccggtc gattccccat
     6301 gcgattgtca tccgtaaaga tacgtttgga aaatataaat tgcgtcagga agccttgaat
     6361 gactatcctc tgtcccgcga ggaggcgcta atgcaggttg tcgaccacct cggggacaat
     6421 gacattgtgg tttccaccac gggcaagctc tcccgtgagc ttttcgagta ccgtgaatcg
     6481 aaagggcagg ggcacgcaag ggatttccta actgtgggtt ccatgggtca cagttcttcc
     6541 attgccctgg ggattgccct tgagaagcct gaccgccgtg tctactgtct tgacggtgac
     6601 ggtgccttta tcatgcacat gggtgctgtc agcaatatcg gcgatctttc tcccaagaat
     6661 tacaggcacg tccttttcaa caacggtgcg catgaatctg tcggcggtca acccacgctc
     6721 ggtttccgtc tggatatcgc ctcgatagcg aaaggttgcg gttatgcgca tgtactgact
     6781 gcctccgaca aggaagggct ttcgtgtgcg cttgagaagc tgtccggcct gtccggcccg
     6841 gttcttcttg aaattaaggt ccggatcgat tcacgtgatg atctgggtcg ccctacgact
     6901 actccggtag agaataaaga gcattttatg gcatttttaa aagatacgca ttcatgaata
     6961 tcgaaagaaa gatccttttg aatccgggtc ccgccaccac gacggatacg gtgaagctgg
     7021 cgcaggttgt tcccgatatc tgtccgcgtg agaaagagtt tgcgggtatg atgaaacagt
     7081 tacgtgacga cctggtccgc gttgcgcatg gagacctttc caaacatacg gccgtcctgt
     7141 tttgcggctc gggtacgatc aatatcgata tctgcctgaa ctctcttctt cctgcggata
     7201 agaaagttct ggtggtcaat aacggtgcct acagcacccg tgcggtggaa gtctgcgaat
     7261 attacggtct tccccatatc gatttgaagt tttccgttta cgaacttccc gacctgtcgg
     7321 taatcgaaaa ggcgctttcc gacaatccgg acatcgcttt ggtctatacc acgcaccatg
     7381 aaacgggtac gggtatcttg aaccccatcc gtgagatcgg aaaaatagcc cattcgcacg
     7441 gtgccgtttt tgttgtcgac accacttcct ccctgggtat gattcctttt gatatcggaa
     7501 aggataatgt tgacttttgt atggcttcgg ctcagaaagg ccttcaggcc atgacgggtc
     7561 tttcctttat cataggtgat gaatccctga tacgtgcttc aagggattat ccgaaacgct
     7621 cctactattg taacctctat ttacaatacg attactttga gaagacgggt gagatgcatt
     7681 ttactcctcc tgttcaaacc gtttacgcag cccgtcaggc tcttgatgaa tattttgcag
     7741 taggtgaaga ggctaaattc gcccgtcaca agagggtctt tgaagccatc cataaaggtt
     7801 tgcaagagct tggtcttcag tatgcgatca aacgtgaatg gcagtcgggt cttgttgttt
     7861 ctgtattgta tcctgatgat cccctctggg attttgataa ggttcatgat tactgctatg
     7921 aacgtggctt tacgatctac ccgggtaaga tttccacaac gaatacattc cggctttgtg
     7981 cgttgggaga gattgatgtg gaggatattg agaggttctt tgaggtgatg aaaagcgtaa
     8041 atacggtatt agttaataaa taatttagct cattcatgtt gaaaaaaagg ttggactatt
     8101 cccaattaaa ggttatacag ttgaatatat taaaagatgt agatgctttt tgtcgtgaaa
     8161 ataatataac ttattattta acttatggga ctttgttggg ggctgtaaga catcaaggat
     8221 atattccttg ggatgacgat attgatattg ctatgccgag gaaagattat gaaaagtttt
     8281 tatcaaatta taatctaaat ggaagtaaaa aaaatgtgta tcaagttgtt gctatagagt
     8341 taaataatgc ttatccttat ccttttggaa aggttcaaga tttatcaact gttttattag
     8401 aatattcaga tattaattat ccgttgggga taaatattga tattttccct attgatggat
     8461 tacctgtaga ccttaaaaaa tcagacaaac attttttgaa gataaagtgg ttaatgatga
     8521 taatgaatct taaaaaagta aaaatcacaa taaaacgttc ttttttgaag aacttaatat
     8581 tattaatagg gaagattttg acacttttga ttccatatcg atttatagtg tgcaaaatgt
     8641 cttatattgc acagaggtat gattatgaga aatctgatta tgtttctaac ttgtcttgtc
     8701 cagatgggaa acatgaacgg acgtctaaaa gagtttttga aaatagtata gagattttat
     8761 ttgaaggtaa taatttctat gctcctatag gatatcatga atggcttcat aatatttatg
     8821 gagattatat gaaaatgcct ccagttccgg aaagagtatc tcatcataaa tttgaaattt
     8881 ataagatact gtaatcatgt gttctaagga taattttctt caagaagttc gtgcattatg
     8941 tatatttact gtaatattgt tacatgtacc atttcaggga catgataata taagttttaa
     9001 tacttggcta atgtcaaagc agttgattac tttccctgtt gctgtgttct tctttttatc
     9061 tggatatttt tattctttta gaaattataa gagtagaatt gttaaattgc tttgtccttt
     9121 tttattttgg aatatgagtg tacatctaat taagtttatt agaggggaaa gcggatttaa
     9181 tattgaaaat tttttattag gtaatggatt accttattat tatttagcag tacttcttca
     9241 gattgtgtta tttcattaca taatctttaa atattggagc gaaatggtat atagagtatt
     9301 gtccataagt attagtatta taagtttgat ggcctattat tatttttcca tttcttattc
     9361 tatccatttt aattgttatc tctattttcc cttttggata ttattctata ctttaggaac
     9421 atttgggaaa aaatattggc gtaatttaat atctaaaata cctttttgtg taattctatt
     9481 gtttatttta atatctgtct ttttgatgtt ttttgaagct aatttaatgt attatatttt
     9541 gtttcaagag ggaattgccg gctctcaggt taagttctct tcctgggtgt attctatact
     9601 aattgtgttg cttttactta aaatagatta ttcaatagac gaaaatgtta ctcgaaattt
     9661 tggtacactt ataggtgact attcatatgg agtctattta attcatatat ttatattatc
     9721 tttaatttat aaattatgta ttgtcgtttt taatgataat tataatgtat tattgccttt
     9781 tatcgcagct tctataacat tggttatttc agtttttatg atttatattt taaataaatg
     9841 tcttcctccc tttatactta aatttttagg attgtatgtt aaaagtaact gatgaatgta
     9901 cggcttgtgg agcttgcttg tctatatgtc caaagaactg tatttctttt aaaagtaatg
     9961 aagaaggttt tttatatcca catattgata tagaaaaatg tgtagattgc gatttgtgtt
    10021 ctaaagtttg ttttttaaat gatcatatta ctccgacttt tagggaaaat gatatcagtt
    10081 attatgcggc taaggctatt gaacgatgta atttgagctc ttctggagga atattcccat
    10141 tgcttgcaga atcagttttg aagaatgacg gcgtagtaat aggagctgct tgggacgata
    10201 aatttaatgt caaacatatt cttattaaat caaaaagtga actgccatta ttatgtggtt
    10261 caaaatacat acagagtaat acagaaaagg tcttcaagat agttaaagaa catctgtcta
    10321 ttcaaactgt tcttttctca ggaacacctt gtcaagtgaa aggacttaaa acatttttgg
    10381 gaaaagatta tgataatttg attacggtcg aattggtttg tcatggagtt ccttcaccat
    10441 tggtttttag acggtatttg aatggggttt tgaaatataa taatttagat atttcacagt
    10501 gtagtaaaat taattttagg gaagtaaaag atgatatcta tagatttgtg atatataata
    10561 agaccaaaat accattttat gaacaatata caaatcttta tactaaaaca tttcttcaaa
    10621 atttattctt acgtaattct tgttataact gtaaatgtaa attggaaaat tccgtaggag
    10681 attttatctt aggagacttt tggggatgta gggatttcta tcctgaattt tatgatccaa
    10741 aaggagttag cttagttatt gtttgtactg aacgtgcaaa aaaaatatgg ttaaatttaa
    10801 aattatcaag aatagaagtt aagaaaaaga ttgtttttag aagtaatagg catttattaa
    10861 aatctgcatc ttataataga aatagagact tgttctttaa aacttttatt catgaggctg
    10921 agatatcact agatgatatt ttgatgggat acacaaataa ggatatttgg gttaaggtta
    10981 aagatttgat aattagtgtt ttacgttttg tggggctttt ccaattagtt caattgtata
    11041 gaaaatgaaa atagcattac ttactttacc atttgttaat aattatggag gaatattaca
    11101 agcttatgct ttaaaacatt ttttagagtt aagagggcat agtgtttgca ttatagatag
    11161 aaattcaaat tttaaaataa gttttattga tatattacgt cttgcaaaaa ggaagtttct
    11221 gggaaataga attcgtaact ttgcttattt taagaagcaa tatttattac caatgacatc
    11281 tgagattata actaataaag aaatgttatt gcttgatgaa aaatatcaat ttgatattta
    11341 tattgttggt agtgaccagg tttggagagc aatatattat agagatatta aatataattt
    11401 ttatttggat tttgtgtcga gtaagaggaa gatatccttt gccgcttctt ttggcatatc
    11461 ttcttgggaa tatacaaaca ctgaaactga tattattgca aaactgttaa tggatttttc
    11521 ttttgtttct gttagagaag atacagcagt aaggttatgt tctgattact tgaatattaa
    11581 tgctgtgcaa ttcctagatc caactttctt attggataaa aacgaatatt gttgtcttgc
    11641 tgattgtttt tatagttcta aaaagattga tatttttgct tatataatgg ggcctgattc
    11701 atctaaagat aaattaatta aaataataag cgattattct ggcttgagtg ttcaatctat
    11761 aactcaaagt aaattctctt ttaaaaagaa tgaaagtatt caagaatggc tacaaaattt
    11821 ttataagtcg aaatttgttg taacagactc ttttcatggt ttagcttttt ctttaatatt
    11881 taataaacct tttattgttt gtggctttag taatagagga atggggagat atgaatcttt
    11941 attgagatat ttctctttgg aaaatagact tttatattca ttggaagatt taaaagaact
    12001 aaatttatct actatttggg atataaattg gaaggaagtt aatgctaaaa ttgctgagaa
    12061 taaaaggttt gtattggagt taatgcagac ggtaggtgta taatgtcact taaagaaaat
    12121 acaatttatg gtgtactgtg gagttcattt gagaaatttg gaactttatc gatacaattt
    12181 atttacatga ttgtgatggc aagattgcta tctccttctg attttggtat agttggcatg
    12241 ttgacaattt ttatttctgt aggccaagtt atacttgata gtggttttgg acaggcttta
    12301 ataagattac aaaaatatga tgatttacat ttttcttcaa tttttataat taatgttatt
    12361 atgggagttc tactctatgg aatattattt tatatggctc catatatttc tttattctat
    12421 agagaaccta gcttaacatt aatttcaaga atatcttttt tgatttttcc catcaattca
    12481 ctaagtatag tccaatatac tttattagtg aaaaaaatgg attttaaatc tatttctaaa
    12541 atatctttat tctcgataat tttatctaca atttcaggta ttacatatgg gtatttttac
    12601 cctaatatat ttgcactatt aattcaaaat gtctcatttt atttttatag gctactttta
    12661 ttatggtatt atggaaactg gaaattatca tgtcgaattt catggagtaa attacaagat
    12721 ttgatgccat tctcttttac gttattagct acaggcttta tttctactgt cgtaggagag
    12781 ttgtattcat tgtctattgg taagttcttt tcttcatctg ttttaggttt atattctcaa
    12841 gcagaaaggt tttcgaaaat tccatctttt tctataacag atgttgttca acgtgtgact
    12901 tatcctgcat tatcagtgtt acaagacgat gatcaaaaat taaagcattc atatagaatg
    12961 gttattatgt gcacattctt tatagtattg cctgtaatgc tttttctttt tattagcgct
    13021 ggcgaaattt ttgaattatt atttactgaa aaatgggaac agg
//
