GCA_030369915.1 - 11 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaAIHENMLD_1 (original name was: gnl|Prokka|AIHENMLD_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	NRPS	170,456	235,866	surfactin	NRP:Lipopeptide	82%
Region 1.2	lanthipeptide-class-iii	693,891	716,488
Region 1.3	PKS-like	884,939	926,183	butirosin A/butirosin B	Saccharide	7%
Region 1.4	terpene	1,010,900	1,031,643
Region 1.5	transAT-PKS,T3PKS	1,772,110	1,822,817	bacillaene	Polyketide+NRP	64%
Region 1.6	NRPS,transAT-PKS,betalactone	1,878,997	1,988,112	fengycin	NRP	100%
Region 1.7	terpene	2,024,644	2,045,567
Region 1.8	T3PKS	2,100,775	2,141,875
Region 1.9	NRPS	2,437,287	2,482,815
Region 1.10	NRP-metallophore,NRPS,RiPP-like	3,017,105	3,068,880	bacillibactin	NRP	100%
Region 1.11	other	3,676,436	3,717,854	bacilysin	Other	100%

Compact view

gnlProkkaAIHENMLD_1 - Region 1 - NRPS

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Location: 170,456 - 235,866 nt. (total: 65,411 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 170455 - 235866:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu - D-Leu) + (Val - Asp - D-Leu) + (Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_190

Search NORINE for peptide: strict or relaxed

AMP-binding (465..867): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: DAKDLGVVDK
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1511..1908): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFMMGMVFK
Nearest Stachelhaus code(s):: Leu DAFMMGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2550..2939): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_191

Search NORINE for peptide: strict or relaxed

AMP-binding (470..864): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1502..1904): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGHIGK
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2547..2936): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_192

Search NORINE for peptide: strict or relaxed

AMP-binding (469..867): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: DGFFLGVVFK
Nearest Stachelhaus code(s):: Ile DGFFLGVVFK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaAIHENMLD_1 - Region 2 - lanthipeptide-class-iii

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Location: 693,891 - 716,488 nt. (total: 22,598 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_708

ctg1_710

Leader:

MKDVLELQQLNEGTEVEASKGKGG

Core:

LLTLITTIVGSSTISNNC

Core with dehydrations:

LLDhbLIDhbDhbIVGDhaDhaDhbIDhaNNCys

MIBiG 3.1 matches for ctg1_710

34.8% BGC0002111 (multiple genes): Lanthipeptide: andalusicin A or andalusicin B

9

VGSSTISNNC

18

V +STISNNC

14

VWASTISNNC

23

30.4% BGC0002111 (EVG22_32245): Lanthipeptide: andalusicin A or andalusicin B

11

SSTISNNC

18

+STISNNC

16

ASTISNNC

23

antiSMASH-DB 4.0 matches for ctg1_710

100.0% NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide

Lanthipeptides: BAMF_RS41655_lanthipeptide

1

LLTLITTIVGSSTISNNC

18

LLTLITTIVGSSTISNNC

1

LLTLITTIVGSSTISNNC

18

94.4% NZ_CP026010.1and 18 others:

NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide

Lanthipeptides: BS11774_RS22075_lanthipeptide

1

LLTLITTIVGSSTISNNC

18

LLTLITTIVG+STISNNC

1

LLTLITTIVGTSTISNNC

18

88.9% NC_014551.1and 27 others:

NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptideNC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptideNZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide

Lanthipeptides: BAMF_RS41670_lanthipeptide

1

LLTLITTIVGSSTISNNC

18

LLTLITT+VG+STISNNC

1

LLTLITTVVGTSTISNNC

18

with 12 more sequence matches

50.0% NC_014551.1and 13 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide

Lanthipeptides: BAMF_RS41660_lanthipeptide

2

LTLITTIVGSSTISNNC

18

TL+TT++G+STISN+C

4

WTLLTTLIGTSTISNSC

20

50.0% NZ_LN868937.1and 1 other:

NZ_LN868937.1 Lanthipeptides: BN2144_RS20095_lanthipeptide

Lanthipeptides: BN2144_RS20100_lanthipeptide

1

LLTLITTIVGSSTISNNC

18

T+ TT++G+STISNNC

4

WYTIFTTLIGTSTISNNC

21

45.0% NZ_JAFFJY010000011.1: Lanthipeptides: JVX89_RS12320_lanthipeptide

7

TIVGSSTISNNC

18

T VG STISN C

9

TTVGLSTISNGC

20

40.9% NZ_LN868937.1: Lanthipeptides: BN2144_RS19915_lanthipeptide

1

LLTLITTIVGSSTISNNC

18

T +T +V +STISN+C

5

WFTSVTLLVTTSTISNHC

22

36.4% NZ_CP066711.1: Lanthipeptides: JGZ56_RS07825_lanthipeptide

2

LTLITTIVGSSTISNNC

18

L+ + + +G STISN+C

6

LSTLLSFLGGSTISNHC

22

34.8% NZ_CP035727.2and 5 others:

NZ_CP035727.2 Lanthipeptides: EVG22_RS16230_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16225_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16220_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16215_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16210_lanthipeptide

Lanthipeptides: EVG22_RS16235_lanthipeptide

9

VGSSTISNNC

18

V +STISNNC

14

VWASTISNNC

23

33.3% NZ_BMVC01000018.1and 6 others:

NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptideNZ_BMVC01000018.1 Lanthipeptides: IE282_RS34455_lanthipeptideNZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20340_lanthipeptideNZ_JALMDK010000006.1 Lanthipeptides: MZC64_RS26320_lanthipeptideNZ_JANBBG010000004.1 Lanthipeptides: allorf_1567890_1567982_lanthipeptideNZ_JANBBG010000004.1 Lanthipeptides: allorf_1567737_1567829_lanthipeptide

Lanthipeptides: IE282_RS34450_lanthipeptide

12

STISNNC

18

ST+SNNC

3

STVSNNC

9

30.8% NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide

Lanthipeptides: BLEG1_RS21170_lanthipeptide

2

LTLITTIVGSSTISNNC

18

+T T++G ST SN+C

10

ITTTRTVIGWSTASNSC

26

30.4% NZ_CP014806.1and 3 others:

NZ_CP014806.1 Lanthipeptides: ATY39_RS17975_lanthipeptideNZ_CP014806.1 Lanthipeptides: ATY39_RS17970_lanthipeptideNZ_CP014806.1 Lanthipeptides: ATY39_RS17965_lanthipeptide

Lanthipeptides: ATY39_RS17980_lanthipeptide

9

VGSSTISNNC

18

V +STISN+C

14

VFASTISNHC

23

30.4% NZ_CP035727.2: Lanthipeptides: EVG22_RS16240_lanthipeptide

11

SSTISNNC

18

+STISNNC

16

ASTISNNC

23

26.7% NZ_CM000752.1and 15 others:

NZ_CM000752.1 Sactipeptides: BTHUR0007_RS37430_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15955_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15950_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33370_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33365_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29070_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29065_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29060_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31360_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31355_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31350_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30820_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30815_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30810_sactipeptideNZ_NUXK01000018.1 Sactipeptides: COJ27_RS31850_sactipeptide

Sactipeptides: BTHUR0007_RS37435_sactipeptide

1

LLTLITTIVGSSTIS

15

LL L+T G+ST S

16

LLNLVTAATGASTAS

30

26.7% NZ_CP066711.1: Lanthipeptides: allorf_1652598_1652744_lanthipeptide

7

TIVGSSTISNNC

18

T+ G STISN C

14

TVYGLSTISNKC

25

ctg1_711

Leader:

MNEVLELQQLSKGSEVE

Core:

TAGWTLLTTLIGTSTISNSCNK

Core with dehydrations:

DhbAGWDhbLLDhbDhbLIGDhbDhaDhbIDhaNDhaCysNK

MIBiG 3.1 matches for ctg1_711

31.8% BGC0000563 (AEA03263.1): Lanthipeptide: venezuelin

7

LTTLIGTSTISNSC

20

L TL+ T I SC

8

LLTLLNTVCIGISC

21

26.1% BGC0002111 (EVG22_32245): Lanthipeptide: andalusicin A or andalusicin B

13

TSTISNSC

20

STISN+C

16

ASTISNNC

23

26.1% BGC0002111 (multiple genes): Lanthipeptide: andalusicin A or andalusicin B

14

STISNSC

20

STISN+C

17

STISNNC

23

antiSMASH-DB 4.0 matches for ctg1_711

100.0% NC_014551.1and 13 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide

Lanthipeptides: BAMF_RS41660_lanthipeptide

1

TAGWTLLTTLIGTSTISNSCNK

22

TAGWTLLTTLIGTSTISNSCNK

1

TAGWTLLTTLIGTSTISNSCNK

22

63.6% NZ_LN868937.1: Lanthipeptides: BN2144_RS19915_lanthipeptide

1

TAGW--TLLTTLIGTSTISNSC

20

TAGW T +T L+ TSTISN C

1

TAGWWFTSVTLLVTTSTISNHC

22

60.9% NZ_LN868937.1: Lanthipeptides: BN2144_RS20095_lanthipeptide

4

WTLLTTLIGTSTISNSCNK

22

+T+ TTLIGTSTISN+C K

5

YTIFTTLIGTSTISNNCGK

23

with 10 more sequence matches

59.1% NZ_LN868937.1: Lanthipeptides: BN2144_RS20100_lanthipeptide

4

WTLLTTLIGTSTISNSC

20

+T+ TTLIGTSTISN+C

5

YTIFTTLIGTSTISNNC

21

54.5% NC_014551.1and 27 others:

NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptideNC_014551.1 Lanthipeptides: BAMF_RS41670_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptideNZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide

Lanthipeptides: BAMF_RS41675_lanthipeptide

4

WTLLTTLIGTSTISNSC

20

TL+TT++GTSTISN+C

2

LTLITTVVGTSTISNNC

18

54.5% NZ_CP026010.1and 18 others:

NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide

Lanthipeptides: BS11774_RS22075_lanthipeptide

4

WTLLTTLIGTSTISNSC

20

TL+TT++GTSTISN+C

2

LTLITTIVGTSTISNNC

18

50.0% NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide

Lanthipeptides: BAMF_RS41655_lanthipeptide

4

WTLLTTLIGTSTISNSC

20

TL+TT++G+STISN+C

2

LTLITTIVGSSTISNNC

18

50.0% NZ_JAFFJY010000011.1: Lanthipeptides: JVX89_RS12320_lanthipeptide

3

GWTLLT-TLIGTSTISNSC

20

G+T T T +G STISN C

2

GYTPTTVTTVGLSTISNGC

20

40.9% NZ_CP066711.1: Lanthipeptides: JGZ56_RS07825_lanthipeptide

3

GWTLLTTLIGTSTISNSC

20

G + L + +G STISN C

5

GLSTLLSFLGGSTISNHC

22

40.9% NZ_FOHE01000012.1and 1 other:

NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20540_lanthipeptide

Lanthipeptides: BMX40_RS20545_lanthipeptide

3

GWTLLTTLIGTSTISNSC

20

GWT T+ ST+SN C

2

GWTWTVTIF-LSTVSNHC

18

34.6% NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide

Lanthipeptides: BLEG1_RS21170_lanthipeptide

9

TLIGTSTISNSC

20

T+IG ST SNSC

15

TVIGWSTASNSC

26

33.3% NZ_CP066711.1: Lanthipeptides: allorf_1652598_1652744_lanthipeptide

9

TLIGTSTISNSCNK

22

T+ G STISN CNK

14

TVYGLSTISNKCNK

27

17.2% NZ_FOHE01000012.1: Lanthipeptides: BMX40_RS20340_lanthipeptide

14

STISNSCNK

22

ST+SN+C++

19

STVSNNCDR

27

ctg1_712

Leader:

MRDVLELQQLSEGTEVEASKGKGG

ctg1_714

Leader:

MRDVLELQQLNEGTEVEASKGKGG

Shared core:

LLTLITTVVGTSTISNNCG

Core with dehydrations:

LLDhbLIDhbDhbVVGDhbDhaDhbIDhaNNCysG

MIBiG 3.1 matches for ctg1_712

34.8% BGC0002111 (multiple genes): Lanthipeptide: andalusicin A or andalusicin B

9

VGTSTISNNC

18

V STISNNC

14

VWASTISNNC

23

30.4% BGC0002111 (EVG22_32245): Lanthipeptide: andalusicin A or andalusicin B

11

TSTISNNC

18

STISNNC

16

ASTISNNC

23

antiSMASH-DB 4.0 matches for ctg1_712

100.0% NC_014551.1and 21 others:

NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide

Lanthipeptides: BAMF_RS41675_lanthipeptide

1

LLTLITTVVGTSTISNNCG

19

LLTLITTVVGTSTISNNCG

1

LLTLITTVVGTSTISNNCG

19

94.7% NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptideNZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide

Lanthipeptides: BAMF_RS41670_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITTVVGTSTISNNC

1

LLTLITTVVGTSTISNNC

18

94.7% NZ_CP026010.1and 9 others:

NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide

Lanthipeptides: BS11774_RS22085_lanthipeptide

1

LLTLITTVVGTSTISNNCG

19

LLTLITT+VGTSTISNNCG

1

LLTLITTIVGTSTISNNCG

19

with 22 more sequence matches

89.5% NZ_CP026010.1and 8 others:

NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide

Lanthipeptides: BS11774_RS22075_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITT+VGTSTISNNC

1

LLTLITTIVGTSTISNNC

18

84.2% NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide

Lanthipeptides: BAMF_RS41655_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITT+VG+STISNNC

1

LLTLITTIVGSSTISNNC

18

56.5% NZ_LN868937.1: Lanthipeptides: BN2144_RS20095_lanthipeptide

1

LLTLITTVVGTSTISNNCG

19

T+ TT++GTSTISNNCG

4

WYTIFTTLIGTSTISNNCG

22

54.5% NC_014551.1and 13 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide

Lanthipeptides: BAMF_RS41660_lanthipeptide

2

LTLITTVVGTSTISNNC

18

TL+TT++GTSTISN+C

4

WTLLTTLIGTSTISNSC

20

54.5% NZ_LN868937.1: Lanthipeptides: BN2144_RS20100_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

T+ TT++GTSTISNNC

4

WYTIFTTLIGTSTISNNC

21

45.5% NZ_LN868937.1: Lanthipeptides: BN2144_RS19915_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

T +T +V TSTISN+C

5

WFTSVTLLVTTSTISNHC

22

45.0% NZ_JAFFJY010000011.1: Lanthipeptides: JVX89_RS12320_lanthipeptide

7

TVVGTSTISNNC

18

T VG STISN C

9

TTVGLSTISNGC

20

36.8% NC_016109.1and 5 others:

NC_016109.1 Lanthipeptides: KSE_RS43700_lanthipeptideNZ_CP068437.1 Lanthipeptides: JK628_RS03400_lanthipeptideNZ_CP068437.1 Lanthipeptides: JK628_RS03395_lanthipeptideNZ_CP068437.1 Lanthipeptides: allorf_0778008_0778106_lanthipeptideNZ_CP068437.1 Lanthipeptides: JK628_RS03405_lanthipeptide

Lanthipeptides: KSE_RS43695_lanthipeptide

12

STISNNCG

19

STISN+CG

2

STISNHCG

9

36.8% NC_016109.1: Lanthipeptides: KSE_RS43705_lanthipeptide

12

STISNNCG

19

STISN CG

2

STISNYCG

9

36.8% NZ_BMVC01000018.1and 1 other:

NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptide

Lanthipeptides: IE282_RS34450_lanthipeptide

12

STISNNCG

19

ST+SNNCG

3

STVSNNCG

10

36.8% NZ_CP014222.1: Lanthipeptides: VN23_RS10390_lanthipeptide

7

TVVGTSTISNNCG

19

V ST+SN+CG

2

QVADWSTVSNHCG

14

36.4% NZ_CP066711.1: Lanthipeptides: JGZ56_RS07825_lanthipeptide

2

LTLITTVVGTSTISNNC

18

L+ + + +G STISN+C

6

LSTLLSFLGGSTISNHC

22

34.8% NZ_CP035727.2and 5 others:

NZ_CP035727.2 Lanthipeptides: EVG22_RS16230_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16225_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16220_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16215_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16210_lanthipeptide

Lanthipeptides: EVG22_RS16235_lanthipeptide

9

VGTSTISNNC

18

V STISNNC

14

VWASTISNNC

23

34.6% NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide

Lanthipeptides: BLEG1_RS21170_lanthipeptide

2

LTLITTVVGTSTISNNC

18

+T TV+G ST SN+C

10

ITTTRTVIGWSTASNSC

26

33.3% NZ_SMBT01000005.1: Lanthipeptides: EV682_RS11315_lanthipeptide

7

TVVGTSTISNNCG

19

T ST+SN+CG

1

TPADWSTVSNHCG

13

31.6% NZ_BMVC01000018.1and 4 others:

NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20340_lanthipeptideNZ_JALMDK010000006.1 Lanthipeptides: MZC64_RS26320_lanthipeptideNZ_JANBBG010000004.1 Lanthipeptides: allorf_1567890_1567982_lanthipeptideNZ_JANBBG010000004.1 Lanthipeptides: allorf_1567737_1567829_lanthipeptide

Lanthipeptides: IE282_RS34455_lanthipeptide

12

STISNNC

18

ST+SNNC

3

STVSNNC

9

31.6% NZ_CP113837.1and 1 other:

NZ_CP113837.1 Lanthipeptides: OU787_RS28895_lanthipeptide

Lanthipeptides: OU787_RS28905_lanthipeptide

12

STISNNCG

19

ST+SN+CG

2

STVSNHCG

9

31.6% NZ_CP113837.1: Lanthipeptides: OU787_RS28900_lanthipeptide

12

STISNNCG

19

ST+SN CG

2

STVSNYCG

9

30.4% NZ_CP014806.1and 3 others:

NZ_CP014806.1 Lanthipeptides: ATY39_RS17975_lanthipeptideNZ_CP014806.1 Lanthipeptides: ATY39_RS17970_lanthipeptideNZ_CP014806.1 Lanthipeptides: ATY39_RS17965_lanthipeptide

Lanthipeptides: ATY39_RS17980_lanthipeptide

9

VGTSTISNNC

18

V STISN+C

14

VFASTISNHC

23

30.4% NZ_CP035727.2: Lanthipeptides: EVG22_RS16240_lanthipeptide

11

TSTISNNC

18

STISNNC

16

ASTISNNC

23

30.0% NZ_CP066711.1: Lanthipeptides: allorf_1652598_1652744_lanthipeptide

7

TVVGTSTISNNC

18

TV G STISN C

14

TVYGLSTISNKC

25

13.2% NZ_JAIQCM010000003.1: Lanthipeptides: K9V56_RS08295_lanthipeptide

11

TSTISNNCG

19

TSTIS CG

33

TSTISGKCG

41

ctg1_713

Leader:

MRDVLELQQLNEGTEVEASKGKGG

Core:

LLTLITTVVGTSTISNNC

Core with dehydrations:

LLDhbLIDhbDhbVVGDhbDhaDhbIDhaNNCys

MIBiG 3.1 matches for ctg1_713

34.8% BGC0002111 (multiple genes): Lanthipeptide: andalusicin A or andalusicin B

9

VGTSTISNNC

18

V STISNNC

14

VWASTISNNC

23

30.4% BGC0002111 (EVG22_32245): Lanthipeptide: andalusicin A or andalusicin B

11

TSTISNNC

18

STISNNC

16

ASTISNNC

23

antiSMASH-DB 4.0 matches for ctg1_713

100.0% NC_014551.1and 27 others:

NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptideNC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptideNZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide

Lanthipeptides: BAMF_RS41670_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITTVVGTSTISNNC

1

LLTLITTVVGTSTISNNC

18

89.5% NZ_CP026010.1and 18 others:

NZ_CP026010.1 Lanthipeptides: BS11774_RS22075_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide

Lanthipeptides: BS11774_RS22085_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITT+VGTSTISNNC

1

LLTLITTIVGTSTISNNC

18

88.9% NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide

Lanthipeptides: BAMF_RS41655_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITT+VG+STISNNC

1

LLTLITTIVGSSTISNNC

18

with 13 more sequence matches

54.5% NC_014551.1and 13 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide

Lanthipeptides: BAMF_RS41660_lanthipeptide

2

LTLITTVVGTSTISNNC

18

TL+TT++GTSTISN+C

4

WTLLTTLIGTSTISNSC

20

52.2% NZ_LN868937.1and 1 other:

NZ_LN868937.1 Lanthipeptides: BN2144_RS20100_lanthipeptide

Lanthipeptides: BN2144_RS20095_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

T+ TT++GTSTISNNC

4

WYTIFTTLIGTSTISNNC

21

45.5% NZ_LN868937.1: Lanthipeptides: BN2144_RS19915_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

T +T +V TSTISN+C

5

WFTSVTLLVTTSTISNHC

22

45.0% NZ_JAFFJY010000011.1: Lanthipeptides: JVX89_RS12320_lanthipeptide

7

TVVGTSTISNNC

18

T VG STISN C

9

TTVGLSTISNGC

20

36.4% NZ_CP066711.1: Lanthipeptides: JGZ56_RS07825_lanthipeptide

2

LTLITTVVGTSTISNNC

18

L+ + + +G STISN+C

6

LSTLLSFLGGSTISNHC

22

34.8% NZ_CP035727.2and 5 others:

NZ_CP035727.2 Lanthipeptides: EVG22_RS16230_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16225_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16220_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16215_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16210_lanthipeptide

Lanthipeptides: EVG22_RS16235_lanthipeptide

9

VGTSTISNNC

18

V STISNNC

14

VWASTISNNC

23

34.6% NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide

Lanthipeptides: BLEG1_RS21170_lanthipeptide

2

LTLITTVVGTSTISNNC

18

+T TV+G ST SN+C

10

ITTTRTVIGWSTASNSC

26

33.3% NZ_BMVC01000018.1and 6 others:

NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptideNZ_BMVC01000018.1 Lanthipeptides: IE282_RS34455_lanthipeptideNZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20340_lanthipeptideNZ_JALMDK010000006.1 Lanthipeptides: MZC64_RS26320_lanthipeptideNZ_JANBBG010000004.1 Lanthipeptides: allorf_1567890_1567982_lanthipeptideNZ_JANBBG010000004.1 Lanthipeptides: allorf_1567737_1567829_lanthipeptide

Lanthipeptides: IE282_RS34450_lanthipeptide

12

STISNNC

18

ST+SNNC

3

STVSNNC

9

33.3% NZ_CP068437.1and 1 other:

NZ_CP068437.1 Lanthipeptides: JK628_RS03395_lanthipeptide

Lanthipeptides: JK628_RS03400_lanthipeptide

12

STISNNC

18

STISN+C

5

STISNHC

11

31.6% NZ_CP014222.1: Lanthipeptides: VN23_RS10390_lanthipeptide

7

TVVGTSTISNNC

18

V ST+SN+C

2

QVADWSTVSNHC

13

30.4% NZ_CP014806.1and 3 others:

NZ_CP014806.1 Lanthipeptides: ATY39_RS17975_lanthipeptideNZ_CP014806.1 Lanthipeptides: ATY39_RS17970_lanthipeptideNZ_CP014806.1 Lanthipeptides: ATY39_RS17965_lanthipeptide

Lanthipeptides: ATY39_RS17980_lanthipeptide

9

VGTSTISNNC

18

V STISN+C

14

VFASTISNHC

23

30.4% NZ_CP035727.2: Lanthipeptides: EVG22_RS16240_lanthipeptide

11

TSTISNNC

18

STISNNC

16

ASTISNNC

23

30.0% NZ_CP066711.1: Lanthipeptides: allorf_1652598_1652744_lanthipeptide

7

TVVGTSTISNNC

18

TV G STISN C

14

TVYGLSTISNKC

25

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg1_710 - Class III

Cleavage pHMM score: 0.00

RODEO score: 0

Monoisotopic mass: 1723.0 Da

Molecular weight: 1724.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1742.0 Da N = 1; 1760.0 Da N = 2; 1778.1 Da N = 3; 1796.1 Da N = 4; 1814.1 Da N = 5; 1832.1 Da N = 6

ctg1_711 - Class III

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 2119.2 Da

Molecular weight: 2120.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2138.4 Da N = 1; 2156.4 Da N = 2; 2174.4 Da N = 3; 2192.5 Da N = 4; 2210.5 Da N = 5; 2228.5 Da N = 6; 2246.5 Da N = 7; 2264.5 Da N = 8

ctg1_712 - Class III

Cleavage pHMM score: 0.00

RODEO score: 0

Monoisotopic mass: 1780.0 Da

Molecular weight: 1781.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1799.1 Da N = 1; 1817.1 Da N = 2; 1835.1 Da N = 3; 1853.1 Da N = 4; 1871.2 Da N = 5; 1889.2 Da N = 6

ctg1_713 - Class III

Cleavage pHMM score: 0.00

RODEO score: 0

Monoisotopic mass: 1723.0 Da

Molecular weight: 1724.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1742.0 Da N = 1; 1760.0 Da N = 2; 1778.1 Da N = 3; 1796.1 Da N = 4; 1814.1 Da N = 5; 1832.1 Da N = 6

ctg1_714 - Class III

Cleavage pHMM score: 0.00

RODEO score: 0

Monoisotopic mass: 1780.0 Da

Molecular weight: 1781.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1799.1 Da N = 1; 1817.1 Da N = 2; 1835.1 Da N = 3; 1853.1 Da N = 4; 1871.2 Da N = 5; 1889.2 Da N = 6

gnlProkkaAIHENMLD_1 - Region 3 - PKS-like

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Location: 884,939 - 926,183 nt. (total: 41,245 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)

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NRPS/PKS domains

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Selected features only

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NRPS/PKS substrates

NRPS/PKS substrate predictions

gnlProkkaAIHENMLD_1 - Region 4 - terpene

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Location: 1,010,900 - 1,031,643 nt. (total: 20,744 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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No matches found.

gnlProkkaAIHENMLD_1 - Region 5 - T3PKS,transAT-PKS

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Location: 1,772,110 - 1,822,817 nt. (total: 50,708 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 5, location 1772109 - 1822817:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_1909

PKS_AT (4..285): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 98.2
inactive: 43.3
Methoxymalonyl-CoA: 36.6
Methylmalonyl-CoA: 24.6
Propionyl-CoA: 24.5
2-Methylbutyryl-CoA: 5.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ctg1_1910

PKS_AT (7..293): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 29.5
inactive: 17.6
Methoxymalonyl-CoA: 11.9
Benzoyl-CoA: 9.4
Isobutyryl-CoA: 8.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg1_1911

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 99.9
inactive: 30.9
Methoxymalonyl-CoA: 28.6
Methylmalonyl-CoA: 15.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

gnlProkkaAIHENMLD_1 - Region 6 - NRPS,betalactone,transAT-PKS

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Location: 1,878,997 - 1,988,112 nt. (total: 109,116 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 6, location 1878996 - 1988112:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - D-Tyr) + (Ile) + (mal - Asn) + (D-Tyr - D-Asn - Gln) + (Pro) + (D-Asn - Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 1878996 - 1956242:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal - Asn) + (D-Tyr - D-Asn - Gln) + (Pro) + (D-Asn - Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 1937915 - 1988112:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_2030

Search NORINE for peptide: strict or relaxed

AMP-binding (268..663): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1778..2185): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLIDK
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_2031

Search NORINE for peptide: strict or relaxed

AMP-binding (425..821): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVVK
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_2032

Search NORINE for peptide: strict or relaxed

AMP-binding (268..662): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DALSVGEVVK
Nearest Stachelhaus code(s):: Tyr DALSVGEVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1778..2173): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3287..3692): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: DAQDLGVVDK
Nearest Stachelhaus code(s):: Gln DAQDLGVVDK (100% 8Å match); Ile DAQDLGVVDK (74% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_2033

Search NORINE for peptide: strict or relaxed

CAL_domain (36..478): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 614.1
NH2: 18.8
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (2956..3351): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_2034

PKS_AT (6..291): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 73.4
inactive: 33.0
Methoxymalonyl-CoA: 19.5
Propionyl-CoA: 13.4
Methylmalonyl-CoA: 11.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg1_2052

AMP-binding (1..348): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -GLHIAAPVK
Nearest Stachelhaus code(s):: Z-ahmohOrn FGLHIASTCK (56% 8Å match); Ile DGLFIGIPVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

ctg1_2057

Search NORINE for peptide: strict or relaxed

AMP-binding (217..610): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFYGITFK
Nearest Stachelhaus code(s):: Ile DAFFYGITFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_2059

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWHFGGVDK
Nearest Stachelhaus code(s):: Glu DAWHFGGVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1066..1458): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DGTITAEVAK
Nearest Stachelhaus code(s):: Tyr DGTITAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaAIHENMLD_1 - Region 7 - terpene

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Location: 2,024,644 - 2,045,567 nt. (total: 20,924 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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gnlProkkaAIHENMLD_1 - Region 8 - T3PKS

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Location: 2,100,775 - 2,141,875 nt. (total: 41,101 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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NRPS/PKS substrates

NRPS/PKS substrate predictions

gnlProkkaAIHENMLD_1 - Region 9 - NRPS

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Location: 2,437,287 - 2,482,815 nt. (total: 45,529 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

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Similar known gene clusters from MIBiG 3.1

No matches found.

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 11, location 2437286 - 2482815:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_2621

Search NORINE for peptide: strict or relaxed

AMP-binding (215..605): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GMVLLAVVVK
Nearest Stachelhaus code(s):: Boz GMVLRAVVVK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1265..1663): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DMFAVACNWK
Nearest Stachelhaus code(s):: Ph-Ser or Phe DAFTVAAIWK (47% 8Å match)
Stachelhaus code match:: 60% (weak)

gnlProkkaAIHENMLD_1 - Region 10 - NRP-metallophore,NRPS,RiPP-like

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Location: 3,017,105 - 3,068,880 nt. (total: 51,776 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX))
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 12, location 3017104 - 3068880:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 13, location 3017104 - 3068832:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_3246

Search NORINE for peptide: strict or relaxed

AMP-binding (456..855): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLIWK
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1513..1929): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_3248

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVVNK
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (97% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaAIHENMLD_1 - Region 11 - other

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Location: 3,676,436 - 3,717,854 nt. (total: 41,419 nt) Show pHMM detection rules used

other: (LmbU or Neocarzinostat or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1