LOCUS       c00001_gnlPro..        16468 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CDMCOEML_1.
ACCESSION   c00001_gnlPro..
VERSION     c00001_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 19:11:51
            Original ID  :: gnl|Prokka|CDMCOEML_1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16468
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..3666
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Molydop_binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Molybdopterin"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitr_red_alph_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1"
                     /sec_met_domain="Molybdopterin (E-value: 7.3e-140,
                     bitscore: 463.7, seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Molydop_binding (E-value: 1.6e-21,
                     bitscore: 73.4, seeds: 74, tool: rule-based-clusters)"
                     /sec_met_domain="Nitr_red_alph_N (E-value: 1.5e-06,
                     bitscore: 25.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSRFFNKVDKFNGTFTQLEENSRRWEKLYRQRWAHDKVVRTTHG
                     VNCTGSCSWNVYVKQGIITWEHQATDYPSCGPNIPGYEPRGCPRGASFSWYEYSPVRIK
                     YPYIRGKLWELWTAAKKEYETPLDAWASIVEDPEKSKKYKKVRGHGGLIRVHRYEALEM
                     ISAACLYTIKKYGPDRIGGFTPIPAMSMMSFSAGARFIALMGGEQMSFYDWYADLPPAS
                     PQVWGEQTDVPESAEWYNSSYIIMWGSNVPLTRTPDAHFMTEVRYKGTKIVAVSPDYAE
                     NVKFADDWLAPEPGSDSAVAQAMTYVILDEFYQKHPVKRFIDYSKRFTDLPFMVELEPS
                     TANGDHYTPGRFVRISDLVADDTIVNPAWKTVVYDQNNHKIVVPNGTMGQEYNAKEKWN
                     LELLDQNGNKIDPALSINDQDGETEQIVADFPAFSNDGNSVVQRHLPVKKLKFTDGKEH
                     LVTNVYDLMMAQMGINRTGNDELAAKDAMDAESYFTPAWQESRSGVKAEQVIQIAREFA
                     QNAAENEGRSMVIMGGGVNHWFNADMNYRNIINMLMLCGCVGMTGGGWAHYVGQEKLRP
                     QEGWANITFANDWEKGGARQMQGTTWYYFATDQWRYEEIDNQAQKSPVWKSKHSYLHNA
                     DYNQMAIRLGWLPSYPQFDRNPLSFAKDYNTTDINEISKKVVDELKKGSLHFAAEDPDA
                     NQNQPKAFFLWRSNLFASSGKGAEYFMKHLLGAENGLLAKPNDRVKPQDMIWRDKGAIG
                     KLDLVVDMDFRMVSTPMYSDVVLPAATWYEKKDLSSTDMHPFIHPFNAAVSPMWESKSD
                     WQQFKLLAKTVSEMAKKYMPGTFYDLKSAPLGHNTQGEIAQPYGEIKDWKNGETEPIPG
                     KTMPSLKLVTRDYTKIYDKYITLGPNIVNNYNYNVDDQYDYLKDMNGIASEGIGAGCPL
                     LDEDEKVCNAILRMSTASNGKLADRAWEKKQERTGEHLTDIGRGHADDSMSFKQITAQP
                     QEAYPTPIGTSAKHGGARYTPFSLMTERNIPTFTLTGRQHYYLDHEIFREFGENMATYK
                     PSLPPVVMAPGDVDVPPVKDEVTLKYMTPHGKWNIHTMYYDNLEMLTLFRGGPTIWISP
                     QDADKIKVKDNDWIEVYNRNGVVTARAVVSVRMPEGSMYMYHAQDNEIYEPLSTITGNR
                     GGSHNAPTQIHVKPTHMVGGYGQLSYGWNYYGPTGNQRDLYANVRKLKKVNWSED"
     protocluster    1..16468
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:6468]"
                     /cutoff="10000"
                     /detection_rule="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /neighbourhood="10000"
                     /product="Nitrate_reductase"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..6468
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /neighbourhood="10000"
                     /product="Nitrate_reductase"
                     /protocluster_number="1"
     cand_cluster    1..16468
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /kind="single"
                     /product="Nitrate_reductase"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16468
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Nitrate_reductase"
                     /region_number="1"
                     /rules="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /tool="gutsmash"
     CDS             3656..5215
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitr_red_bet_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Fer4_11"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2"
                     /sec_met_domain="Fer4_11 (E-value: 4.5e-37, bitscore:
                     123.3, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.07, bitscore: 10.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="Nitr_red_bet_C (E-value: 2.2e-26,
                     bitscore: 88.4, seeds: 110, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKIKAQISMVLNLDKCIGCHTCSVTCKNTWTNRPGAEYMWFNNVE
                     TKPGVGYPKRWEDEDQYHGGWTLNSKGKLKLRAGSKLNKIALGKIFYNNDMPELDNYYE
                     PWTYDYKTLFGPEQKHQPVARPKSQITGEGMELTTGPNWDDDLAGSTEYVQQDPNMQKI
                     EGDIKNNFEQAFMMYLPRLCEHCLNAPCVASCPSGAMYKRDEDGIVLVDQERCRGWRFC
                     MTGCPYKKVYFNWKTHKAEKCTFCYPRIEEGQPTVCAETCVGRIRYIGAILYDADRVEE
                     AASTPDESKLYEAQLGLFLDPNDPEVVKQALKDGISEEMIEAAQKSPIYKMAVKEKIAF
                     PLHPEYRTMPMVWYIPPLSPVMSYFEGRDSIKNPEMIFPGIDQMRVPVQYLASLLTAGN
                     VPVIKKALYKLAMMRLYMRAKTSGRDFDSSKLERVDLTEERATSLYRLLAIAKYEDRFV
                     IPSSQKAEMEDAQTEQGSLGYDECEGCALAPQHKSMFKKAEAGKSTNQIYADSFYGGIW
                     RD"
     CDS             5208..5786
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitrate_red_del"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3"
                     /sec_met_domain="Nitrate_red_del (E-value: 5.4e-07,
                     bitscore: 26.7, seeds: 108, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIDFRRLTDLKDTFAVLSRLIDYPDTETFSPEIRQLLLTDNVLST
                     ATRGELLSLFDELATLSPIEVQEMYAHLFEMNRRYTLYMSYYKMTDSRERGTILARLKM
                     LYEMFGISEATSELSDYLPLLLEFLAYGDYTNDPRRQDIQLALSVIEDGTYTLLKNAVT
                     DSDSPYIQLIRLTRSLIGSCIKMEVQEDA"
     CDS             5779..6468
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitrate_red_gam"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4"
                     /sec_met_domain="Nitrate_red_gam (E-value: 2.1e-75,
                     bitscore: 250.0, seeds: 140, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHNGWSIFLWVIYPYIMLASFFIGTFVRFKYFHPSITAKSSELFE
                     KKWLMIGSVTFHIGIILAFFGHCLGMFIPASWTAYFGITEHMYHIFGSLMMGIPAGILA
                     FVGIAILTYRRMTCSRVYKTSDINDIIVDWALLITIALGLVCTITGAFIDYNYRTTISP
                     WARSLFVLNPQWQLMRSVPLIYKIHVLCGLAIFGYFPYTRLVHALTLPWQYIFRRFIVY
                     RRRARVY"
     CDS             complement(6537..7427)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MNIKSVPKKQLWGIELNLISLLFSSISPVLNKFSLTSLSPVVGGI
                     FTSAFAAIFTFATILITHQHVSLTNLKNLWLWLLGGTNAIGIILQYIALSTLSPITVTL
                     IARMYLVYVFFLSYVFLKEKITKWDYLAIILCILGSFFISGSRLQFSDNLLGLICAFIY
                     PLMYAANNIVAKYLVSDEEPNNVLFFNHFTSALLLFCYALITGTSFSHISSQAVAFNFG
                     GAFFNGFMSLLLFYTSLQFITAGKANIVRALGPVIVIIYSSFFFPVQVTPSLVLGAVLV
                     ILASTIVTFTRTNHE"
     CDS             complement(7536..8183)
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MSTKKRVYIPKNKTNGQIKGKRKIWVENVKFLTLEEYDQLRETIK
                     LHSRPELVNRNLLLIAIALNNGLRASDVVTLRVGHVLNKTKTRVIEQKTGKAKTLFWNN
                     CLAEIINYLNDLDYKDENDYLFPGKQEGHFSVHGFYEMLQRMARKTENNKIVAKIGTHS
                     FRKTFGRQLYKKGVNVEIISQLFNHSSERNTRHYLGIEQEDLDKVVQNFKFE"
     CDS             complement(8200..9054)
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MLYNAALVLEGGAFRGQYTAGIVDTFLAHHIEFRSVIGVSAGSLC
                     GVNFVSKQYGRAANININHRHDRQYISMARVFKKQIINLDYLFEDHGYSWQNFNEAAYR
                     RSASHFTAVATSVKTGKTVLFTDPVGEELTNALKASSSMPFLSDPQETSQGPCLDGGIT
                     DSIPFDIAQQQGYDKIVVVRTRDVNYRKKPSSSAVKKLYDMVYKDYHEFAKAGINRPLL
                     YNQQIAEINRLSREGKIFNIAPSKPIKIKRIEGNIKKIRALYETGRKEGEEIVPALVDY
                     LAN"
     CDS             9525..11894
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MYKSGKNWAVVTLSTAALVFGATTVNASADTNTENNDSSTVQVTT
                     GDNDIAVKSVTLGSGQVSAASDATIKNSANANSDSSAANTQNSNSQVASSAATTSSTSS
                     ASSSTNTDSKATKENTNVAKEDDTQKAAPANESSEAKSEPAVNTNDSSAAKNDDQQSSK
                     KNTAAKLNKDAENVVKKAGIDPNSLTDDQIKALNKINFSKTAKSGTQMTYNDFQKIADT
                     LIKQDGRYTVPFFKASEIKNMPAATTKDAQTNTIEPLDVWDSWPVQDVRTGQVANWNGY
                     QLVIAMMGVPNQNDNHIYLLYNKYGDNELSHWKNAGPIFGYNATALSQEWSGSAVLNSD
                     NSIQLFYTRVDTSDNNTNHQKIASATLYLTDNNGNVSLAQVANDHIVFEGDSYYYQTYD
                     QWKATNKGADNIAMRDAHVIEDDNGDRYLVFEASTGSENYQGEEQIYNWLNYGGDDAFN
                     IKSLFRILSNDDIKSRATWANAAIGILKLNKDEKNPKVAELYSPLISAPMVSDEIERPN
                     VVKLGNKYYLFAATRLNRGSNDDAWMNANYTVGDNVAMVGYVADSLTGSYKPLNDSGVV
                     LTASVPANWRTATYSYYAVPVAGKDDQLLVTSYMTNRNGVAGKGMDSTWAPSFLLQINP
                     DNTTTVLAKMTNQGDWIWDDSSENLDMIGDLDSAALPGERDKPVDWDLIGYGLKPHDPA
                     TPKNPETPTTPETPETPNTPETPKTPENPGTPQTPETPNTPEVPLTPENPKQPETQTNN
                     RLPQTGNNANKAVIGLGMGTLLSMFGLAGINKRRFN"
     CDS             complement(11993..12166)
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MEEKILGFITSLFGKKQYVCPFCHEHYTFSAMHARKLADKDGQIH
                     CYYCRKVLQQLH"
     CDS             complement(12224..13303)
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MEADKYLKLIQEELQNLPDYVNEYYLGTNHAVTTTYQYLTEIRRF
                     FDWLRSSGLISVNSNKDLPIDTLANLRRSDVMLYIDYLQHTTNAQGRLNSPTSINRSIN
                     ALRSLYKFLTVTADNNNGESYFDRNVMLKIDSLNDTKTLNYRAHTLASHMYRGQMKFDF
                     ITFIEKEYPNKCDKRALPSYKVNKERDIAIIALILGTGVRVSEAANVNLGDLNLKQSLL
                     DVTRKGGQRDSVPIAPWAITYIKAYQTIRAQRYHALKKDTAFFLTVYHKQTRRMTANAI
                     EKMVKKYSTAFGHPLTPHKLRHTLASEMYEVTKDQVLVAQQLGQKGTSATDLYTHVDQK
                     QQRDALKEISETSYKKTNE"
     CDS             13652..14071
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MELIPNRYPICYIDYVDELVPEEKITATKNVTINESFFRGHFPNN
                     PVMPGVLIIETLAQAASILILKSPHFYKKTAYLGAIHKARFRQMVRPGDVLKLNVVMKK
                     VRSSMGIVETQALVNDKIACNAELVFIVAEREEKI"
     CDS             14158..14604
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MSKDNDYEKINKGLIKVYSGILWIEENELRKSTFNDLTIKEMHAI
                     DAITMYNHQTISQVAEKLHLTPGTMTSMADRLIRKGYVERIRDKDDRRIVRLRLTKRGR
                     VLYRAHRAFHNMMVERFLKGMNDEEMKVVKKALQNLEDFVDEHA"
     CDS             14624..15598
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ACP_syn_III"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ACP_syn_III_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_13"
                     /sec_met_domain="ACP_syn_III (E-value: 3.7e-27, bitscore:
                     91.0, seeds: 136, tool: rule-based-clusters)"
                     /sec_met_domain="ACP_syn_III_C (E-value: 2.5e-29, bitscore:
                     98.4, seeds: 152, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LQNLRITSTASYHPPLNITNQQLSTIMDTSDEWIKLRTGIHQRYI
                     SNTENTSDLAFNVGNQLLTNANLKATELDLIIIATMSPDAYTPSTAAIVQGRLGAKNAI
                     AFDISAACTGFIYAINTAELMLKSSNWQNAMVIGAEVLSKLIDWKDRRTAVLFGDGAGG
                     VLLQKTTTATPLILGRDLHTFGELGDKIIAGKTTPKAGFPKKLTSLSPFAMAGRDVYRF
                     ATHEVPRSITSAVQQANLKLDDIDYFLLHQANERIITQIAKRLAQPITKFPMNISEYGN
                     TGAASEPILLTQVVAHELVKPGNIIAMSGFGGGLSTGTIILNY"
     CDS             15612..15860
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MNMTREEIFDTVKTITVDELDVEEDRVTMNARIKDDLDADSLDVF
                     EIMNELEDKFEIELDADEGIETISDVVDFVKKQLDEK"
ORIGIN
        1 atgaagtcac ggttctttaa caaggttgat aagtttaatg gaacctttac acaacttgag
       61 gaaaatagtc gtcgttggga aaagctttat cgccagcgat gggcccatga caaagttgtc
      121 cgaacaactc atggagtcaa ctgtacaggc tcatgttctt ggaatgttta tgtcaagcaa
      181 ggaattatta cttgggaaca tcaagccaca gattatccat catgcggacc taatattcca
      241 ggatatgaac cacggggatg tcctcgggga gctagtttct cttggtatga atacagtccc
      301 gttcgaatta agtatccata tattcgcggc aaattatggg agctttggac tgctgccaag
      361 aaagaatatg aaaccccctt agatgcgtgg gcaagtattg tcgaagatcc agaaaagtct
      421 aaaaaatata agaaggtccg aggacacggt ggcttaattc gtgttcatcg ttatgaagca
      481 ctagaaatga tttcagctgc ttgcttatac acgattaaga agtatgggcc tgatcgcatt
      541 ggtggtttca ccccaattcc tgcaatgtca atgatgagtt tcagtgccgg agcacggttc
      601 attgccttaa tgggtgggga acaaatgagt ttctacgatt ggtatgctga tctaccacct
      661 gcatctcccc aagtttgggg tgaacagact gatgttccag aatccgcaga atggtataac
      721 agttcttaca ttattatgtg gggatcaaat gtcccattaa ctcggacgcc ggatgcacac
      781 ttcatgacag aagttaggta taaaggaaca aagattgtgg cggttagccc tgattatgct
      841 gaaaatgtaa aatttgctga tgactggctt gcaccagaac caggtagtga ttctgctgtt
      901 gctcaagcca tgacctatgt aattttagat gaattctacc aaaagcaccc agttaaacgt
      961 ttcattgatt attccaagcg atttactgat ttaccattca tggttgaatt ggaaccaagt
     1021 acagcaaatg gtgatcacta tacaccaggt cgcttcgtcc ggattagtga cttagttgct
     1081 gatgatacaa ttgtcaatcc agcatggaag acagttgttt atgaccaaaa taaccacaag
     1141 attgttgttc caaatggaac gatgggacaa gaatataatg ctaaggaaaa atggaatctt
     1201 gaattattag accaaaatgg taataagatt gatccggcac tctctattaa tgatcaagat
     1261 ggcgaaactg aacaaattgt tgctgatttt ccagcattta gtaatgacgg aaacagcgtt
     1321 gtgcaacgtc atttaccagt taaaaagctc aaattcacag atggcaaaga acatttagta
     1381 actaacgttt atgatttgat gatggctcaa atgggaatta atcggactgg taatgatgaa
     1441 cttgctgcta aagatgcaat ggatgctgag agctacttta ctcctgcttg gcaggaaagc
     1501 cgttcgggag taaaagcaga gcaagttatt caaattgctc gtgaatttgc ccaaaacgcg
     1561 gccgaaaatg aagggcggag tatggtaatc atgggtggtg gggttaacca ctggttcaat
     1621 gccgatatga actatcgaaa cattattaat atgctgatgt tgtgtggttg tgttggtatg
     1681 actggtggtg gttgggctca ctacgttggt caagaaaagc tccgtccaca agagggttgg
     1741 gcaaatatta cttttgctaa tgactgggaa aaaggtggtg cccgtcaaat gcaaggtact
     1801 acttggtatt actttgcaac tgatcaatgg cgttatgaag aaattgataa ccaggctcaa
     1861 aaatcacctg tttggaagag taaacattcc tacttacata atgctgatta taatcaaatg
     1921 gcaattcgtt taggatggtt accatcatac ccacaatttg atcgtaatcc gttatctttt
     1981 gcaaaagatt acaatacaac tgatattaat gaaatttcaa agaaagttgt cgatgaattg
     2041 aagaagggct ctttacattt tgctgctgaa gatcctgatg ctaaccaaaa tcaacccaaa
     2101 gcgttcttct tatggcgttc aaacttattt gcttcttctg gcaaaggtgc cgaatacttt
     2161 atgaaacatt tattaggcgc tgaaaatgga ttgcttgcta aacctaatga tcgagttaag
     2221 ccccaggata tgatttggcg tgacaaagga gcgattggta agttagatct tgttgttgat
     2281 atggacttcc gaatggtttc aacaccaatg tactccgatg ttgtcctacc agctgctact
     2341 tggtatgaaa agaaggacct ttcatcaact gatatgcatc catttattca cccatttaat
     2401 gcagcagtta gtccaatgtg ggaatcaaag tctgactggc aacaattcaa gctcttggct
     2461 aagactgttt ctgaaatggc aaagaaatac atgccgggaa ccttctatga tcttaagagc
     2521 gcaccactag gacataatac tcaaggggaa attgctcaac catatgggga aattaaagat
     2581 tggaagaacg gtgaaacaga accaatccct gggaaaacca tgccttcttt aaaattagtt
     2641 acccgtgatt atactaagat ctatgacaaa tacatcactc ttggccctaa tatagtaaat
     2701 aattataact ataacgttga tgatcaatat gattacctca aagacatgaa tggaattgct
     2761 agtgaaggca ttggtgcagg ctgtccatta cttgatgaag acgaaaaagt atgtaatgca
     2821 atcttacgaa tgtcaactgc ttccaatggt aaactcgctg atcgagcttg ggaaaagaag
     2881 caagaacgga ctggtgaaca tttgacagat attggtcgcg gtcatgctga tgattcaatg
     2941 tcgtttaagc aaatcactgc tcaaccacaa gaagcctatc caacaccaat cggaacttct
     3001 gctaaacatg gtggagctcg ctacacacca ttttcattaa tgactgaacg aaatattcct
     3061 acatttactc ttacaggacg tcagcattac taccttgatc atgaaatttt ccgtgaattt
     3121 ggtgaaaata tggcaactta taaaccatct ttgccaccgg ttgtaatggc tccaggagat
     3181 gttgatgttc cgccagtaaa agatgaagtt acacttaaat atatgactcc tcatggtaaa
     3241 tggaatattc atacgatgta ctacgataac cttgaaatgt tgacattatt ccggggtggt
     3301 ccaactattt ggattagtcc ccaagatgcc gataagatca aggtaaaaga taatgactgg
     3361 attgaagttt ataaccgtaa tggggttgtt actgcgcggg cggttgtttc tgttcggatg
     3421 cctgaggggt caatgtacat gtaccacgcc caagataacg aaatttacga acctctttct
     3481 accattaccg gtaatcgtgg gggatcgcat aatgcaccaa cgcaaatcca tgttaagcca
     3541 acgcatatgg ttggtggata tggacaattg agttacggtt ggaattacta tggaccaact
     3601 ggaaaccaac gtgatcttta tgcaaatgta agaaaactga agaaggtgaa ctggagtgaa
     3661 gattaaagca caaatcagca tggtcttaaa cctcgataag tgtattggtt gtcatacctg
     3721 ttcagtaact tgtaagaata catggacaaa tcgtccaggc gctgaataca tgtggtttaa
     3781 taatgttgaa actaagccag gtgtcggtta tccaaaacgc tgggaagatg aagatcaata
     3841 ccatggaggg tggaccctta attcaaaagg taaattaaaa ttacgtgctg gaagcaaatt
     3901 aaataaaatt gctcttggca agatttttta caataatgat atgccagagt tagataacta
     3961 ctacgaacca tggacctatg actataagac attatttggt cctgaacaaa agcaccaacc
     4021 cgttgctcgt cctaagtcgc aaattactgg cgaaggaatg gaattaacca ctggtcctaa
     4081 ctgggatgat gacttagcag gatcaactga atatgtccaa caggatccta acatgcaaaa
     4141 aattgaaggg gatatcaaaa ataactttga gcaggcattt atgatgtatc ttccccggtt
     4201 atgtgagcac tgtttaaatg cgccttgtgt agcctcttgt ccatcaggtg caatgtataa
     4261 acgagatgaa gatgggattg ttttagtaga ccaagaacgc tgtcgaggat ggcgtttttg
     4321 catgactgga tgtccatata agaaggtcta ctttaactgg aagactcata aagctgaaaa
     4381 atgtactttt tgctatccgc gaattgaaga aggccaacca acagtttgcg ccgaaacctg
     4441 tgtcggtcga attcgatata ttggtgctat tctatacgat gctgatcgag tagaagaggc
     4501 agcttcaact cctgatgaga gtaagctgta tgaagcacaa cttggcttat tcctcgatcc
     4561 caacgatcct gaagttgtca agcaagcact caaggatggc atttctgaag agatgattga
     4621 ggctgcacaa aagtcaccga tctataaaat ggcagtaaaa gaaaagattg ccttcccgct
     4681 tcacccagaa taccggacaa tgccaatggt ttggtacatt ccgccgctat caccagttat
     4741 gagttacttt gaaggacggg actcaataaa gaatcctgaa atgatcttcc caggaattga
     4801 tcaaatgcgg gtgcctgttc aatacttggc aagtctatta actgctggaa acgttcctgt
     4861 catcaagaaa gccttatata aacttgcaat gatgcggcta tacatgcgtg ctaagactag
     4921 tggtcgggat tttgatagca gtaaactaga acgagttgat ttaacagaag aacgggcaac
     4981 atcactttat cgtttactgg caattgctaa atatgaagac cgctttgtta ttccaagtag
     5041 ccaaaaggca gaaatggaag atgcacaaac cgaacaaggt agtcttggct atgatgaatg
     5101 tgaaggctgt gcattagctc cccaacacaa gagtatgttt aagaaggcag aagctggcaa
     5161 atcaactaat cagatttatg ctgatagttt ctatggaggg atttggcgtg attgatttta
     5221 gacgattgac agatttaaag gatacatttg ccgttctttc ccgtttgatt gactatcctg
     5281 atacagaaac gttttcacca gagattcgtc aattgttact tacggataac gtattatcaa
     5341 ctgcaacgcg gggagaatta ttaagcctct ttgatgaatt agctacatta tctccaatcg
     5401 aagttcaaga gatgtacgct cacctttttg aaatgaatcg acgctatact ctttatatgt
     5461 catactacaa gatgactgat tcccgtgaac gaggaaccat tttggcgcgg ttgaaaatgc
     5521 tatatgagat gtttggtata tcagaggcga ctagtgaact ttctgattat ttgcctctat
     5581 tgttagaatt tctagcatat ggcgattata ctaatgatcc gcgtcgtcag gatatccaat
     5641 tagcattaag tgtgattgaa gatggaactt ataccctttt aaaaaatgca gtgacagata
     5701 gtgatagtcc ctatattcag ttaatcaggc ttacacgttc attaattggt tcgtgtatta
     5761 aaatggaggt gcaagaagat gcataatggc tggtcaattt tcttatgggt tatttatcca
     5821 tatataatgt tggcatcatt tttcattgga acatttgtta gatttaaata ttttcatccc
     5881 tcaattactg ccaaatcaag tgaacttttt gaaaagaaat ggctaatgat cggaagcgtt
     5941 actttccaca ttggaattat tttagctttc tttggccact gcttaggaat gtttatccca
     6001 gcaagttgga cagcttattt tgggatcact gaacatatgt accacatctt tgggtcattg
     6061 atgatgggaa ttccagcagg gatccttgca tttgtgggaa ttgcgattct gacttatcga
     6121 cgaatgactt gttctcgtgt ttataagaca agtgatatca atgatattat tgtcgactgg
     6181 gctttactga ttacaattgc attaggtcta gtatgtacta ttacgggtgc atttatcgat
     6241 tacaactatc gaacaacgat tagtccatgg gcaagaagcc tatttgttct taatcctcaa
     6301 tggcaattga tgcgttcagt gccattaatt tataaaattc acgttctctg tggattagca
     6361 atttttggtt acttcccata cacccggttg gttcacgctt taacgctacc ttggcaatat
     6421 attttccgtc gttttattgt ttatcgtcga cgcgcaaggg tttattaata tataagaaga
     6481 tataataaaa gcatcagatt tcttcacagg gaaattctga tgcttttata ttacgattat
     6541 tcgtgatttg ttcttgtaaa ggtaacaatt gtactagcta aaattactaa aacagctcct
     6601 aagactaggg aaggagttac ctgaacagga aagaaaaatg aagagtaaat aataacaatt
     6661 actgggccaa gtgcacgaac aatatttgct ttaccagcgg taataaactg caagctagta
     6721 tagaaaagaa gtagtgacat gaagccatta aagaatgctc caccaaagtt aaatgcaact
     6781 gcttgactag aaatatggct aaatgacgtt cctgttataa gagcatagca gaaaagtaaa
     6841 agagccgaag taaaatggtt aaagaacaaa acattatttg gttcttcatc actaactagg
     6901 tacttagcca cgatattgtt ggcggcatac attagtgggt agatgaatgc acaaatcaag
     6961 ccgagaagat tatcactaaa ttgaagacgg ctccctgaaa taaagaagga accgaggatg
     7021 caaagaataa ttgctaagta atcccacttt gtaatctttt cctttaagaa gacataagat
     7081 aggaagaaaa cgtaaactaa atacatccgc gcaataaggg taaccgtgat tggacttaga
     7141 gttgagaggg caatgtattg aagaataatt ccgattgcat ttgttccacc caaaagccat
     7201 aaccacaggt tcttaagatt agtcaaagaa acatgctgat gcgtaatgag gattgttgca
     7261 aaagtaaaaa ttgcagcaaa agcactagtg aaaattcccc caacaaccgg acttaagcta
     7321 gtaagtgaaa atttattaag aaccggacta atactactaa ataggagaga aatcagattt
     7381 aattcaattc cccatagttg cttctttgga acacttttta tattcattta gtcacatcca
     7441 atacttttta ttactttaat tctaatgaat tattttccta agtctattag gaaaatgact
     7501 aaatatttta gtttacataa tattcgaaat aataactatt caaatttaaa gttttgaaca
     7561 actttatcga ggtcttcttg ttcaatccct aggtagtgac gtgtatttcg ttcagaggag
     7621 tggttaaaca actgggaaat aatttcaacg ttaacacctt tcttatagag ttgtcgacca
     7681 aaagtctttc taaaagagtg cgttccaatc ttagcaacga ttttattgtt ttccgttttt
     7741 ctagccattc gttgaagcat ctcataaaag ccgtgtacag aaaaatggcc ttcttgtttt
     7801 ccagggaaaa ggtaatcatt ttcatcttta taatctaagt cattaaggta attaataatc
     7861 tcggcaaggc aattattcca aaagagcgtt ttagctttac cagttttttg ttcaataaca
     7921 cgggttttag ttttatttag aacatgacca actcttaacg ttacaacgtc tgatgctcgt
     7981 aatccattat tgagggcaat tgcaattagt aataggttac gattaaccaa ttcaggacga
     8041 gaatgcaatt taattgtctc acgtaactga tcatattctt caagggtcaa aaacttaaca
     8101 ttttctaccc atattttccg tttaccctta atttgaccat tcgtcttatt tttgggaata
     8161 taaacgcgtt tcttagttga cataatattt cttcctttgt taatttgcga ggtaatcaac
     8221 taaagcaggg acgatttcct ctccttcttt ccgcccggtt tcataaagtg ctcgaatctt
     8281 cttaatattt ccttcaatcc gcttaatttt aattggttta gagggagcaa tattaaagat
     8341 ctttccttca cgagataaac gattgatttc agcaatctgt tggttgtaga gaaggggacg
     8401 attaatcccc gctttagcaa attcgtgata atctttatat accatgtcgt ataacttctt
     8461 tacagcagaa ctggacggct tctttcggta gttaacatcc ctggttcgaa caacaacaat
     8521 cttgtcataa ccttgttgtt gtgcaatatc aaatggaatt gaatctgtga tcccaccatc
     8581 aaggcaagga ccttgggaag tttcctgtgg atctgaaaga aatggcattg atgaggaagc
     8641 tttgagggca ttggttagct cctcaccaac aggatccgta aataaaactg tttttcctgt
     8701 ttttactgaa gtagcgacgg ctgtgaaatg agaggctgac cgacgatagg ctgcttcatt
     8761 aaaattctgc caagaatatc cgtgatcctc aaaaaggtaa tcaagattaa ttatttgctt
     8821 tttaaatacg cgagccatcg agatatattg gcgatcgtgc cgatgattaa tattaatatt
     8881 ggctgcgcgt ccgtattgct tagagacgaa attaactcca caaagcgaac cagcagaaac
     8941 gccaattaca cttcgaaatt caatatggtg agcgagaaat gtatcgacaa ttccggcagt
     9001 gtattggcca cggaatgcgc caccttctaa aactaatgct gcattatata acataaaatg
     9061 aaataactcc tttttgtcca ctaaaatagc aaaaatgacc taatttttag cgagacactt
     9121 tttcaataaa attatacaac agtcttacgc gaaaatatag gattttaaaa gcttgttata
     9181 tcaacgttta ttctcggtta atgtaagact ctttcatcaa aagagtctta ctaattttaa
     9241 aataatgcaa aaatagggat aaaaacagct tttgcctctc agacgaactg aaattcattt
     9301 tgatgagcag taggtcgtta caattcgtct cagaaggaaa acgcatattg ctatcaaaaa
     9361 atgagtaaat agacagtaaa tatttaaata tgaacttttt atgaagaaac tattgataat
     9421 ttaagataat cataataaaa tagtgcacag ttaattgtta aacgtttagc aaaaagtaaa
     9481 gaaacggggt tatttctatg ctagaacgca aggaacataa gaaaatgtat aaaagcggta
     9541 aaaattgggc agttgttaca ctttctactg ctgcgttggt gtttggtgca acaactgtaa
     9601 acgcatccgc ggacactaat actgaaaata atgattcttc tactgtacag gttacaactg
     9661 gcgataatga tattgctgtt aaaagtgtga cacttggtag tggtcaagtt agtgcagcta
     9721 gtgatgcgac tattaaaaat tctgctaatg caaatagtga ttcttctgcc gctaatacac
     9781 aaaattctaa cagtcaggta gcaagttctg ctgcaacaac ttcatctaca agttcagcat
     9841 cttcatcaac taacacagat agtaaagcaa ctaaagaaaa tactaatgta gctaaagagg
     9901 atgatacaca aaaagctgca cccgctaacg aatcttctga agccaaaagc gaaccggctg
     9961 taaacactaa tgattcttca gctgccaaaa acgatgatca acaatccagt aaaaagaata
    10021 ctgccgctaa gttaaacaag gatgctgaaa acgttgtaaa aaaggcggga attgatccta
    10081 acagtttaac tgatgaccag attaaagcat taaataagat taacttctcg aaaactgcaa
    10141 aatctggtac ccaaatgact tataatgatt tccaaaagat tgccgatacg ttaatcaaac
    10201 aagatggtcg gtatacagtt ccattcttta aagcaagtga aatcaaaaac atgcctgccg
    10261 ctacaactaa agatgcacaa actaatacta ttgagccttt agacgtatgg gattcatggc
    10321 cagttcaaga tgttcggaca ggacaagttg ctaattggaa tggctatcaa cttgtcatcg
    10381 caatgatggg ggttccaaac caaaatgata atcacatcta tctcttatat aataagtatg
    10441 gtgataatga attaagtcat tggaagaatg caggtccaat ttttggctat aatgctactg
    10501 cgctttcaca agaatggtca ggatcagctg ttttgaacag tgataactct atccaattat
    10561 tttatacaag ggtagacacg tctgataaca ataccaatca tcaaaaaatt gctagcgcta
    10621 ctctttattt aactgataat aatggaaatg tgtcactcgc tcaggtagca aatgatcata
    10681 ttgtattcga aggtgatagc tattactacc aaacttatga tcaatggaaa gctactaaca
    10741 agggtgctga taatattgca atgcgtgatg ctcatgtaat tgaagatgat aatggtgatc
    10801 ggtaccttgt ttttgaagca agtactggtt cagaaaatta tcaaggcgag gaacaaattt
    10861 ataactggtt aaattatggc ggagatgacg cctttaatat caagagctta tttagaattc
    10921 tttccaatga tgatattaag agtcgggcaa cttgggctaa tgcagctatc ggtatcctca
    10981 aactaaacaa ggacgaaaag aatcctaaag tggcagaatt atactcacca ttaatttctg
    11041 caccaatggt aagtgatgaa attgaacgac caaatgtggt taaattaggt aataagtatt
    11101 acttgtttgc cgctacccgt ttaaatcgag gaagtaatga cgatgcttgg atgaatgcca
    11161 attatacggt tggtgataat gttgcaatgg tcggatatgt tgctgatagt ctaactggat
    11221 cttataagcc attaaatgat tctggagtag tcttaactgc ttctgttcct gcaaactggc
    11281 gaacggcaac ttattcatac tacgctgtgc ctgttgccgg aaaagacgat caattgttag
    11341 ttacttcata tatgactaat cgaaatggag tagcgggtaa aggaatggat tcaacttggg
    11401 caccgagttt cttactacaa attaaccctg ataacacaac tactgtttta gctaaaatga
    11461 ctaatcaagg ggattggatt tgggatgatt caagtgaaaa tcttgatatg attggtgatc
    11521 tagattctgc tgccttacct ggtgaacgtg ataagcctgt tgattgggac ttaattggct
    11581 atggattaaa gccgcatgat cctgctacac caaagaatcc tgaaacgcca actactccag
    11641 aaacccctga gacgcctaat actccagaaa caccaaagac tcctgaaaat cctgggacac
    11701 ctcaaactcc agagacacct aacactccag aagtgccttt aactccagaa aatcctaagc
    11761 aacctgaaac ccaaaccaat aatcgtttgc cacaaactgg aaataacgct aataaagccg
    11821 taattggcct aggtatggga acattgctta gtatgtttgg ccttgcagga attaacaagc
    11881 gtcgattcaa ctaaatactt taaaaaataa aaccgctaag ctttaaatgt agcttaacgg
    11941 ttttttattt tgaaagtttt tattatcgaa aaaacaaatc ctcgttaatc ctttaatgca
    12001 attgttgtaa aaccttgcga cagtaataac agtggatttg cccatctttg tcagctaact
    12061 tccgtgcatg cattgcagaa aaagtatagt gctcatgaca aaatggacaa acatattgct
    12121 tctttccaaa tagtgaggta ataaagccca aaattttctc ctccataaaa aatttataca
    12181 ctgcttaaca ttatagcgaa gattatcttt atagaaaagc cttttattca tttgtctttt
    12241 tatatgaagt ttcactaatt tctttaagag catcacgttg ctgcttctga tcaacatggg
    12301 tatataaatc agtagcagat gttccttttt gtcccaactg ttgggctact aatacctgat
    12361 ctttcgttac ctcatacatt tcagaagcaa gggtatgacg taatttatgg ggagtaaggg
    12421 gatgtccaaa tgcagttgaa tactttttga ccattttttc aattgcatta gctgtcatcc
    12481 gtcgagtttg cttgtgataa acggttagga agaaagcagt atcttttttt aaagcgtggt
    12541 atcgctgtgc acgaatcgtt tgataagctt tgatataagt aatagcccaa ggtgcaattg
    12601 gcactgaatc tctctggcca ccttttcttg ttacgtccag cagtgattgc ttcaagttta
    12661 aatccccaag gtttacgtta gctgcctcgg atacccggac gcctgttcct aaaataagag
    12721 caataattgc aatatctcgt tccttattga ctttataaga ggggagagct cttttatcac
    12781 atttattagg atattctttt tcaatgaagg taataaaatc aaatttcatt tgtccccggt
    12841 acatgtgtga agccagcgta tgcgcccgat aatttaatgt ttttgtatca ttaagggagt
    12901 cgattttcag cattacatta cggtcaaaat aagactcgcc attattgtta tctgcggtga
    12961 ctgttaaaaa tttatacaat gaccttaatg cattaataga gcgattaatt gaagtgggag
    13021 aatttaaccg tccttgcgca ttggtagtat gctgtaaata atcgatatac agcattacat
    13081 cgctacgccg taaattagcc agtgtatcaa ttggtaagtc cttattagag ttaacagaga
    13141 taagtccact tgaccgtaac caatcaaaga atcggcggat ttcagttaag tactgatagg
    13201 ttgttgtgac tgcatggttg gtccccaaat aatactcatt aacataatca ggaaggttct
    13261 gaagctcctc ttgaattagc tttaaatatt tatctgcttc catttttata tcctccttga
    13321 tactaaaaag agccgcttga aagaaaactt tcaacgactc tctaaaccta tcgggaaaac
    13381 aggattcgaa cctgcgaccc cctggtccca aaccaggtgc tctaccaagc tgagctattt
    13441 cccgttaata acgaacaaat attattttac caattctcaa ttaaatagta aagaaatatt
    13501 ttaatttgca agcattaaga attaaatgat ataaaataat ttgacattca aaatattttt
    13561 gaatataatt tgatcatcga atattttgat actcgaaata ttttttgaag gcaggtgaat
    13621 ctttttggca ataatgaatg cgcaggagat tatggaatta attcctaatc gatatccgat
    13681 ttgctacatc gattatgtag acgaattagt tcctgaagaa aagattaccg caacaaaaaa
    13741 tgtcacaatt aacgaatcat tttttcgcgg tcattttcct aataatcctg ttatgcctgg
    13801 agttttaatt atcgaaacat tggcccaagc tgcttcaatt ttgatattaa aatcaccgca
    13861 tttttataag aaaacagctt atcttggcgc aattcataaa gcgaggtttc gacaaatggt
    13921 ccgtcctggt gatgtattaa aactaaatgt tgttatgaaa aaagttcgat catcaatggg
    13981 aattgtggaa acacaagcgc ttgtgaacga caaaatagct tgtaatgcag aacttgtctt
    14041 tatcgttgct gaacgagaag aaaagattta gcatggtgaa tcattatcat ttataatata
    14101 ttttgataat caaattattc ggggctatag aataaaattg aagggaagaa atatattatg
    14161 agtaaagata atgattacga aaaaatcaat aaaggattaa tcaaagtcta ttccggaatt
    14221 ctatggattg aagaaaatga gttacggaaa agtacattca atgatttaac aattaaagag
    14281 atgcatgcaa ttgatgcaat tacgatgtat aaccatcaaa caatttctca agtagcagaa
    14341 aagcttcatc taaccccagg aacaatgact tcaatggctg accgtttaat tcgaaaagga
    14401 tatgttgaaa gaattcgtga taaagatgat cgccgcattg ttcggttacg tttaaccaaa
    14461 agaggacggg tactatatcg tgcgcaccgg gcctttcata acatgatggt tgaacgtttc
    14521 ctcaaaggaa tgaatgatga agaaatgaag gttgttaaaa aagccttaca aaacttagaa
    14581 gattttgtgg atgagcatgc ttagagataa ggattgacaa acattgcaaa atttaagaat
    14641 tactagtact gcgagttatc atccaccact taatattact aaccaacaat tatcaactat
    14701 tatggatact tcagatgagt ggattaaatt gcggactgga attcatcaac gttatatcag
    14761 caatactgaa aacacttcag acttggcttt taatgttggt aatcagttat tgactaatgc
    14821 caatttgaaa gcaactgaac ttgatttaat tattattgca acgatgtctc ctgatgccta
    14881 tacgccgtca actgctgcca ttgttcaagg aagattaggg gcgaaaaatg caattgcgtt
    14941 tgatatttca gcagcttgta ctggttttat ctatgccatt aatacagctg aattaatgtt
    15001 gaaaagctct aattggcaaa atgcaatggt aattggtgca gaagtattat caaaactgat
    15061 tgactggaaa gatcgacgta ctgccgtatt gttcggcgat ggggctggcg gagtgttact
    15121 tcaaaagaca actacggcaa ctcctttaat tctcggccgt gatcttcata catttggtga
    15181 gttgggagat aaaattattg ccggaaaaac aacgcctaaa gctggcttcc ctaagaaact
    15241 aacatccctt tcaccatttg cgatggccgg ccgtgacgta tatcgttttg ctactcatga
    15301 agtaccgcgc tcaattactt ctgccgttca acaagctaat ttaaaattag acgatatcga
    15361 ttatttttta ttacatcagg caaatgaacg gataattact caaattgcaa agagactggc
    15421 gcaaccaatt acaaagtttc caatgaatat tagtgaatat ggaaatacgg gcgccgctag
    15481 tgaaccaatt ttattgactc aagttgttgc tcatgaattg gttaaaccag gtaacattat
    15541 tgcaatgagt ggttttggcg gcggtttaag tacaggaaca ataattttaa attattaata
    15601 gagaaagaag aatgaatatg actagagaag aaatttttga tactgtaaaa actattactg
    15661 ttgatgaatt agatgttgag gaagatcgtg taacaatgaa cgcgcgaatt aaagatgatc
    15721 tagatgctga cagtcttgat gttttcgaaa ttatgaatga acttgaagat aagtttgaga
    15781 ttgaattaga tgccgatgaa ggaattgaga ctattagtga cgttgttgat ttcgtaaaga
    15841 aacaattgga tgaaaaataa tgtactacgg aatattattt agcggtcaag gtgcacagcg
    15901 atcgggaatg ggagtcgagc ttatggccga ctcccttttt tcaaggattg ttagtcaggc
    15961 aagtgatatt tgtgagcttg atttactcaa aattatgaaa aacgagcata acgagttgaa
    16021 taaaacagca tatgttcaac cagcaattgt aacagttagt tatggaatct accgaatgtt
    16081 aaaacgggat ttaccgcaac taccaattaa ggggatgatc ggcctatcct taggcgagta
    16141 cgctgcctta attgctagta attcacttcc gtttgaagaa ggaatcaaac tagttgcgga
    16201 tcgtgctcgc tttatgcaac aagacgcgga tagggaaata agtacgttag tagctgtcct
    16261 tgaccctcaa cttcaagaaa taaaagaact aatcaccgtt caacaagaaa atggtcagcg
    16321 ggtttatatc gccaactata attcaccacg acaaatcgta gtgggcgggg cattacccga
    16381 cctaaaagct acccttaaaa agatggaaga agacaagctt gctaaaagaa cgattctgct
    16441 caaagttaat ggcgcatttc atactccc
//
