LOCUS gnlProkkaPLIAIPEN_14 25686 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|PLIAIPEN_14. ACCESSION gnlProkkaPLIAIPEN_14 VERSION gnlProkkaPLIAIPEN_14 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2025-04-28 18:28:05 Original ID :: gnl|Prokka|PLIAIPEN_14 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 25686 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..25686 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="True" /core_location="[1858:5686]" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" /tool="antismash" proto_core 1859..5686 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" cand_cluster 1..25686 /SMILES="NC(CC(C)C)C(=O)O" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(Condensation and (AMP-binding or A-OX))" /kind="single" /product="NRPS" /protoclusters="1" /tool="antismash" region 1..25686 /candidate_cluster_numbers="1" /contig_edge="True" /product="NRPS" /region_number="1" /rules="cds(Condensation and (AMP-binding or A-OX))" /tool="antismash" CDS 2..1822 /NRPS_PKS="Domain: PCP (62-130). E-value: 4.4e-28. Score: 89.2. Matches aSDomain: nrpspksdomains_ctg13_1_PCP.1" /NRPS_PKS="Domain: Epimerization (140-443). E-value: 7.4e-162. Score: 531.7. Matches aSDomain: nrpspksdomains_ctg13_1_Epimerization.1" /NRPS_PKS="Domain: TIGR01720 (447-596). E-value: 1.1e-54. Score: 176.4. Matches aSDomain: nrpspksdomains_ctg13_1_TIGR01720.1" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) Condensation" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 136.7; E-value: 2.1e-41)" /gene_kind="biosynthetic-additional" /locus_tag="ctg13_1" /sec_met_domain="PP-binding (E-value: 1.2e-17, bitscore: 58.1, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="Condensation (E-value: 1e-85, bitscore: 281.2, seeds: 42, tool: rule-based-clusters)" /transl_table=11 /translation="MADIEALKSALKETLPDYMIPAFWVTLNELPVTANGKVDRKALPE PDIEAGSGEYKAPTTDMEDLLAGIWQDVLGMSEVGVTDNFFSLGGDSIKGIQMASRLNQ HGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVEGEVILTPIQRWFFEKNFTNKHH WNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVYREENGDIVQAYKPIGESKVSFEI VDLYGSDEEMLRSQIKILANKLQSSLDLRTGPLLKAEQYRTEAGDHLLIAVHHLVVDGV SWRILLEDFASGYMQAEKEESLVFPQKTNSFKDWAEELAAFSQSAHLLQQAEYWSQIAA EQVSPLPKDCETEQRIVKDTSSVLCELTEEDTKHLLTDVHQPYGTEINDILLSALGLTM KEWTKGAKIGINLEGHGREDIIPNVNISRTVGWFTAQYPVVLDISDADASAVIKTVKEN LRRIPDKGVGYGILRYFTETAETKGFTPEISFNYLGQFDSEVKTDFFEPSAFDMGRQVS GESEALYALSFSGMIRNGQFVLSCSYNEKEFERATVEEQMERFKENLLMLIRHCTEKED KEFTPSDFSAEDLEMDEMGDIFDMLEENLK" aSDomain 188..391 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg13_1_PCP.1" /evalue="4.40E-28" /label="ctg13_1_PCP.1" /locus_tag="ctg13_1" /protein_end="130" /protein_start="62" /score="89.2" /tool="antismash" /translation="EDLLAGIWQDVLGMSEVGVTDNFFSLGGDSIKGIQMASRLNQHGW KLEMKDLFQHPTIEELTQYVERA" aSModule 188..1789 /domains="nrpspksdomains_ctg13_1_PCP.1" /domains="nrpspksdomains_ctg13_1_Epimerization.1" /domains="nrpspksdomains_ctg13_1_TIGR01720.1" /incomplete /locus_tags="ctg13_1" /tool="antismash" /type="unknown" aSDomain 422..1330 /aSDomain="Epimerization" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg13_1_Epimerization.1" /evalue="7.40E-162" /label="ctg13_1_Epimerization.1" /locus_tag="ctg13_1" /protein_end="443" /protein_start="140" /score="531.7" /tool="antismash" /translation="EGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTL QALIEHHDALRMVYREENGDIVQAYKPIGESKVSFEIVDLYGSDEEMLRSQIKILANKL QSSLDLRTGPLLKAEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESL VFPQKTNSFKDWAEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSS VLCELTEEDTKHLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDII PNVNISRTVGWFTAQYPVVLDI" CDS_motif 437..466 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_1_0001" /evalue="3.70E-05" /label="NRPS-E1" /locus_tag="ctg13_1" /protein_end="155" /protein_start="145" /score="16.3" /tool="antismash" /translation="LTPIQRWFFE" CDS_motif 527..601 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_1_0002" /evalue="2.20E-06" /label="C2_LCL_024-062" /locus_tag="ctg13_1" /protein_end="200" /protein_start="175" /score="20.1" /tool="antismash" /translation="FDPERVEKTLQALIEHHDALRMVYR" CDS_motif 806..871 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_1_0003" /evalue="4.00E-12" /label="NRPS-E2" /locus_tag="ctg13_1" /protein_end="290" /protein_start="268" /score="38.2" /tool="antismash" /translation="LLIAVHHLVVDGVSWRILLEDF" CDS_motif 1274..1324 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_1_0004" /evalue="1.50E-08" /label="NRPS-E5" /locus_tag="ctg13_1" /protein_end="441" /protein_start="424" /score="26.6" /tool="antismash" /translation="NISRTVGWFTAQYPVVL" aSDomain 1343..1789 /aSDomain="TIGR01720" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg13_1_TIGR01720.1" /evalue="1.10E-54" /label="ctg13_1_TIGR01720.1" /locus_tag="ctg13_1" /protein_end="596" /protein_start="447" /score="176.4" /tool="antismash" /translation="ASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEISFNY LGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGQFVLSCSYNEKEFERA TVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGD" CDS_motif 1364..1423 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_1_0005" /evalue="9.20E-12" /label="NRPS-E6" /locus_tag="ctg13_1" /protein_end="474" /protein_start="454" /score="37.0" /tool="antismash" /translation="VKENLRRIPDKGVGYGILRY" CDS_motif 1457..1486 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_1_0006" /evalue="1.60E-03" /label="NRPS-E7" /locus_tag="ctg13_1" /protein_end="495" /protein_start="485" /score="10.8" /tool="antismash" /translation="PEISFNYLGQ" aSDomain 1859..1954 /aSDomain="NRPS-COM_Nterm" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg13_2_NRPS-COM_Nterm.1" /evalue="1.40E-16" /label="ctg13_2_NRPS-COM_Nterm.1" /locus_tag="ctg13_2" /protein_end="32" /protein_start="0" /score="51.3" /tool="antismash" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQ" CDS 1859..5686 /NRPS_PKS="Domain: NRPS-COM_Nterm (0-32). E-value: 1.4e-16. Score: 51.3. Matches aSDomain: nrpspksdomains_ctg13_2_NRPS-COM_Nterm.1" /NRPS_PKS="Domain: Condensation_DCL (9-308). E-value: 3.7e-119. Score: 389.1. Matches aSDomain: nrpspksdomains_ctg13_2_Condensation_DCL.1" /NRPS_PKS="Domain: AMP-binding (469-867). E-value: 1.9e-112. Score: 367.7. Matches aSDomain: nrpspksdomains_ctg13_2_AMP-binding.1" /NRPS_PKS="Domain: PCP (973-1042). E-value: 1.5e-25. Score: 81.1. Matches aSDomain: nrpspksdomains_ctg13_2_PCP.1" /NRPS_PKS="Domain: Thioesterase (1059-1267). E-value: 1.8e-37. Score: 121.8. Matches aSDomain: nrpspksdomains_ctg13_2_Thioesterase.1" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 333.5; E-value: 3.9e-101)" /gene_kind="biosynthetic" /locus_tag="ctg13_2" /sec_met_domain="Condensation (E-value: 1.2e-93, bitscore: 307.3, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 1.1e-122, bitscore: 403.4, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 8e-18, bitscore: 58.6, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKG SLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFQIEEIDLTHLTGSEQT AKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLF KVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEDFEGQTTFAEQRKKQ KDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVV SGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKQLQEQSLQSEPHQYVPLYDIQ SQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMASPGDEML IKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFLLTGLNPPA QAHETKPLTDWFKEAVNVNPDAPALTYSGQTLSYRELDEEANRLARRLQKHGAGKGSVV ALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEMKEQAA ELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKGNMTTHANIQGL VKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTDLIL QENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKALRVMGPGKLINCY GPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCISGMG VSKGYVNRADLTKEKFIKNPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIRGHRI ELEEIEKQLQEYPGVKDAVVVADRPESGDASINAYLVNRTQLSAEDVKAHLKKQLPAYM VPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNEMEETIAQIWSEVLGRKQ IGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAPTIAGISAYVKNGGPDGLQ DVTIMNQDQERIIFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADLIQK LQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVESDV EALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFDMPE WLASWEEATTGAYRMKRGFGTHAEMLQGETLDRNAEILLEFLNTQTVTVS" aSDomain 1886..2782 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg13_2_Condensation_DCL.1" /domain_subtypes="Condensation_DCL" /evalue="3.70E-119" /label="ctg13_2_Condensation_DCL.1" /locus_tag="ctg13_2" /protein_end="308" /protein_start="9" /score="389.1" /tool="antismash" /translation="QDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKGSLNIKCLEE SMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFQIEEIDLTHLTGSEQTAKINEYKEQ DKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLFKVYNALREQ KPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEDFEGQTTFAEQRKKQKDGYEPKEL LFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVVSGRPAEIKG VEHMVGLFINVVPRRVKL" aSModule 1886..5659 /complete /domains="nrpspksdomains_ctg13_2_Condensation_DCL.1" /domains="nrpspksdomains_ctg13_2_AMP-binding.1" /domains="nrpspksdomains_ctg13_2_PCP.1" /domains="nrpspksdomains_ctg13_2_Thioesterase.1" /final_module /locus_tags="ctg13_2" /monomer_pairings="Leu -> Leu" /tool="antismash" /type="nrps" CDS_motif 1895..1936 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_2_0001" /evalue="3.00E-05" /label="C1_DCL_004-017" /locus_tag="ctg13_2" /protein_end="26" /protein_start="12" /score="15.8" /tool="antismash" /translation="YYLSPMQEGMLFHA" CDS_motif 1958..2074 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_2_0002" /evalue="2.50E-12" /label="C2_DCL_024-062" /locus_tag="ctg13_2" /protein_end="72" /protein_start="33" /score="39.1" /tool="antismash" /translation="FYLEQITMKVKGSLNIKCLEESMNVIMDRYDVFRTVFIH" CDS_motif 2291..2356 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_2_0003" /evalue="1.70E-11" /label="C3_DCL_135-156" /locus_tag="ctg13_2" /protein_end="166" /protein_start="144" /score="36.5" /tool="antismash" /translation="YHHIILDGWCFGIVVQDLFKVY" CDS_motif 2402..2440 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_2_0004" /evalue="5.50E-04" /label="C4_DCL_171-183" /locus_tag="ctg13_2" /protein_end="194" /protein_start="181" /score="12.4" /tool="antismash" /translation="PYKDYIKWLEKQD" CDS_motif 2678..2773 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_2_0005" /evalue="1.30E-18" /label="C5_DCL_263-294" /locus_tag="ctg13_2" /protein_end="305" /protein_start="273" /score="59.4" /tool="antismash" /translation="DLAFGTVVSGRPAEIKGVEHMVGLFINVVPRR" CDS_motif 2822..2935 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_2_0006" /evalue="1.00E-17" /label="C67_DCL_14fromHMM" /locus_tag="ctg13_2" /protein_end="359" /protein_start="321" /score="56.6" /tool="antismash" /translation="QEQSLQSEPHQYVPLYDIQSQADQPKLIDHIIVFENYP" aSDomain 3266..4459 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg13_2_AMP-binding.1" /evalue="1.90E-112" /label="ctg13_2_AMP-binding.1" /locus_tag="ctg13_2" /protein_end="867" /protein_start="469" /score="367.7" /specificity="substrate consensus: Leu" /tool="antismash" /translation="FKEAVNVNPDAPALTYSGQTLSYRELDEEANRLARRLQKHGAGKG SVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEMKE QAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKGNMTTHANI QGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTD LILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKALRVMGPGKLI NCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCIS GMGVSKGYVNRADLTKEKFIKNPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIR" CDS_motif 3452..3493 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_2_0007" /evalue="2.60E-05" /label="NRPS-A_a2" /locus_tag="ctg13_2" /protein_end="545" /protein_start="531" /score="17.4" /tool="antismash" /translation="LGVLKAGAAYLPVD" CDS_motif 3686..3745 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_2_0008" /evalue="1.40E-08" /label="NRPS-A_a3" /locus_tag="ctg13_2" /protein_end="629" /protein_start="609" /score="26.9" /tool="antismash" /translation="AYIMYTSGTTGKPKGNMTTH" CDS_motif 4253..4342 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_2_0009" /evalue="5.50E-13" /label="NRPS-A_a6" /locus_tag="ctg13_2" /protein_end="828" /protein_start="798" /score="41.1" /tool="antismash" /translation="PFGAIGELCISGMGVSKGYVNRADLTKEKF" CDS_motif 4424..4489 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_2_0010" /evalue="9.60E-12" /label="NRPS-A_a8" /locus_tag="ctg13_2" /protein_end="877" /protein_start="855" /score="36.8" /tool="antismash" /translation="YAGRIDDQVKIRGHRIELEEIE" aSDomain 4778..4984 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg13_2_PCP.1" /evalue="1.50E-25" /label="ctg13_2_PCP.1" /locus_tag="ctg13_2" /protein_end="1042" /protein_start="973" /score="81.1" /tool="antismash" /translation="EETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELG IDLPVKLLFEAPTIAGISAYVKNG" aSDomain 5036..5659 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg13_2_Thioesterase.1" /evalue="1.80E-37" /label="ctg13_2_Thioesterase.1" /locus_tag="ctg13_2" /protein_end="1267" /protein_start="1059" /score="121.8" /tool="antismash" /translation="IIFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADL IQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVE SDVEALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFD MPEWLASWEEATTGAYRMKRGFGTHAEMLQGETLDRNAEILLEFL" CDS_motif 5183..5257 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_2_0011" /evalue="6.30E-10" /label="NRPS-te1" /locus_tag="ctg13_2" /protein_end="1133" /protein_start="1108" /score="31.5" /tool="antismash" /translation="QPEGPLTLFGYSAGCSLAFEAAKKL" CDS 5715..6443 /NRPS_PKS="Domain: Thioesterase (14-231). E-value: 2.8e-55. Score: 180.1. Matches aSDomain: nrpspksdomains_ctg13_3_Thioesterase.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (smcogs) SMCOG1004:thioesterase (Score: 213.1; E-value: 5.1e-65)" /gene_kind="biosynthetic-additional" /locus_tag="ctg13_3" /sec_met_domain="Abhydrolase_6 (E-value: 5.1e-15, bitscore: 50.5, seeds: 455, tool: rule-based-clusters)" /sec_met_domain="PF00561 (E-value: 2e-06, bitscore: 21.4, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLAA EPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGV FPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSD YRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQ TEEVAERIFAILNQHPIIQP" aSDomain 5757..6407 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg13_3_Thioesterase.1" /evalue="2.80E-55" /label="ctg13_3_Thioesterase.1" /locus_tag="ctg13_3" /protein_end="231" /protein_start="14" /score="180.1" /tool="antismash" /translation="QLICFPFAGGYSASFRPLHAFLQGECEMLAAEPPGHGTNQTSAIE DLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGVFPQAVIISAIQPPH IQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSDYRALEQFELYDLAQ IQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQTEEVAERIF" CDS_motif 5940..6011 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg13_3_0001" /evalue="1.90E-08" /label="NRPS-te1" /locus_tag="ctg13_3" /protein_end="99" /protein_start="75" /score="26.7" /tool="antismash" /translation="PDRPFVLFGHSMGGMITFRLAQKL" CDS 6544..7770 /gene_functions="transport (smcogs) SMCOG1137:Major facilitator superfamily MFS 1 (Score: 336.7; E-value: 2.6e-102)" /gene_kind="transport" /locus_tag="ctg13_4" /transl_table=11 /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADRS LISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFSAI YGVLGGIGYSCAVGVTTQYFISRWFDTHKGLALAILTNANSAGLLLLSPIWAAAPYHAG WQSTYTILGIVMAAVLLPLLVFGMKHPPHAQVESVKKFYDWRGFWNVMKQSRLIHILYF GVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLGSRSVM LSILFVIRLLSLICLLIPILGIHHSELWYFGFILLFGLSYTGVIPLTAASISESYQTGL IGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIELVPFLDKQ KAKETHQSI" CDS complement(7785..8342) /locus_tag="ctg13_5" /transl_table=11 /translation="MIQYANESINLPGEIAFKDVREIFFYQIAKISCFYFLLFCAIFAA VNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKSKR TYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIEIPKRFFHSKEEIN RFKEIILKNTGTKKLKFKKDQH" CDS complement(8396..9334) /gene_functions="transport (smcogs) SMCOG1166:transporter, EamA family (Score: 155.8; E-value: 2.6e-47)" /gene_kind="transport" /locus_tag="ctg13_6" /transl_table=11 /translation="MVKHQQAPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRFT IAFAAATVPILFGWVKLSIRVKDVIAILPLALLYPALFFSFQAFGLVYSSSSEAGIIQA AIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLILLSA LSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPFREPG FVLGIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGVVILKESLAWYH LAGAVCIMIGVVGSNINLEKKTKRPGMPAKK" CDS 9458..9865 /gene_functions="regulatory (smcogs) SMCOG1136:GntR family transcriptional regulator (Score: 64.2; E-value: 2.2e-19)" /gene_kind="regulatory" /locus_tag="ctg13_7" /transl_table=11 /translation="MEKYMSLVTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVIR ALQELEKRHLIYSVPKSGYYIVKKTGKAKSGQPGPIDFATSAPDPNVFPYLDFQHCINK AIDTYLWDAKGASITHPCSPKALGHSTGICG" CDS 9837..10775 /NRPS_PKS="Domain: Aminotran_1_2 (8-306). E-value: 4.9e-19. Score: 60.5. Matches aSDomain: nrpspksdomains_ctg13_8_Aminotran_1_2.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1019:aminotransferase (Score: 206.7; E-value: 9e-63)" /gene_kind="biosynthetic-additional" /locus_tag="ctg13_8" /sec_met_domain="Aminotran_1_2 (E-value: 2e-18, bitscore: 60.5, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MATQQVFADERHIFITSGVQQALSLLCAMPFPNGKEKIAIEQPGY HLMVEQLETLGIPAIGVKRTEEGLDIAGVERLFQTESIKFFYTMPRFHNPLGCSLSERD KQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSSHVIYLKSFSKMIFPGLRVG AAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGMYGRHKEKIRDSYKERSLRLH QAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASRVIHRLKKQGVLLEAIDRHYLS DYPKENLLKINISNVKTEDIERGVKLLMSHL" aSDomain 9861..10754 /aSDomain="Aminotran_1_2" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg13_8_Aminotran_1_2.1" /evalue="4.90E-19" /label="ctg13_8_Aminotran_1_2.1" /locus_tag="ctg13_8" /protein_end="306" /protein_start="8" /score="60.5" /tool="antismash" /translation="DERHIFITSGVQQALSLLCAMPFPNGKEKIAIEQPGYHLMVEQLE TLGIPAIGVKRTEEGLDIAGVERLFQTESIKFFYTMPRFHNPLGCSLSERDKQELVRLA EAYDVYLVEDDYLGDLEENKKADPLYAYDLSSHVIYLKSFSKMIFPGLRVGAAVLPEAL TDTFYAYKKLNDIDCSMISQAALEIYLKSGMYGRHKEKIRDSYKERSLRLHQAIRTHRQ LGSGRFTFSSGQAPCMHTHLVLPQDLPASRVIHRLKKQGVLLEAIDRHYLSDYPKENLL KINISNVKTEDIERGVK" CDS complement(10770..11444) /NRPS_PKS="Domain: ACPS (103-166). E-value: 6e-20. Score: 63.4. Matches aSDomain: nrpspksdomains_ctg13_9_ACPS.1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1012:4'-phosphopantetheinyl transferase (Score: 188.7; E-value: 1.5e-57)" /gene_kind="biosynthetic-additional" /locus_tag="ctg13_9" /transl_table=11 /translation="MKIYGIYMDRPLSQEENERFMTFISPEKREKCRRFYHKEDAHRTL LGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVIGAFDSQPI GIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQEGKGLSL PLDSFSVRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAAHPDFPEDITMVSYEE LL" aSDomain complement(10947..11135) /aSDomain="ACPS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg13_9_ACPS.1" /evalue="6.00E-20" /label="ctg13_9_ACPS.1" /locus_tag="ctg13_9" /protein_end="166" /protein_start="103" /score="63.4" /tool="antismash" /translation="IGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWS MKESFIKQEGKGLSLPLD" CDS complement(11549..12196) /locus_tag="ctg13_10" /transl_table=11 /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSLF QHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPAPSTYT GSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMEITILFA AWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH" CDS complement(12517..13260) /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 221.9; E-value: 1.6e-67)" /gene_kind="transport" /locus_tag="ctg13_11" /transl_table=11 /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLLR CLNALEIPNRGELAFDNFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENVME GPIQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPELML FDEPTSALDPELVGEVLKVIKNLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVIVEQG PPEQIFSAPKEERTQRFLNRILNPL" CDS complement(13274..13978) /gene_functions="transport (smcogs) SMCOG1096:polar amino acid ABC transporter, inner membrane (Score: 244.4; E-value: 1.7e-74)" /gene_kind="transport" /locus_tag="ctg13_12" /transl_table=11 /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFIF GMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFPSA VIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIPPLS NTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQH VIERRLDRYVAK" CDS complement(13965..14771) /gene_functions="biosynthetic-additional (smcogs) SMCOG1091:glutamine-binding lipoprotein glnH (Score: 234.5; E-value: 1.7e-71)" /gene_kind="biosynthetic-additional" /locus_tag="ctg13_13" /transl_table=11 /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKG VLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLNSK RFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLTSNY NKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAFETGD PQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK" CDS complement(14887..15759) /gene_functions="regulatory (smcogs) SMCOG1014:LysR family transcriptional regulator (Score: 246.3; E-value: 6.3e-75)" /gene_kind="regulatory" /locus_tag="ctg13_14" /transl_table=11 /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELGV VLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYCAA LMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQLDDI PCVLVLSDEAGYPCGDTIKMEDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPRIVCE CHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTDSYLPK PAQQFLDLF" CDS 15849..16463 /gene_functions="biosynthetic-additional (rule-based-clusters) Flavoprotein" /gene_kind="biosynthetic-additional" /locus_tag="ctg13_15" /sec_met_domain="Flavoprotein (E-value: 1.7e-32, bitscore: 105.9, seeds: 143, tool: rule-based-clusters)" /transl_table=11 /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHLV VSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSLAS IRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMPAFY NQPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA" CDS 16466..17887 /locus_tag="ctg13_16" /transl_table=11 /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGAAARAASNLGDK SPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMPVK REETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQNVGI YRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPLLYDQ SEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTGHYSGG RSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPNEIVAVN AMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFNLPQVMWA LSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHYSQPLDSPL TTKEWEQKLMDLMNK" CDS 17904..18131 /locus_tag="ctg13_17" /transl_table=11 /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESIT NPEKYNPAFKIDPKETETAIEVPAVPERKA" CDS 18128..18592 /locus_tag="ctg13_18" /transl_table=11 /translation="MIGVNSMSDRLFELLDGRCLNEKQHEAFVLQTVSEDGWPHAAMIS AGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKDAE YDRDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLGRWEKTLEDLKR" CDS 18658..19503 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1036:alpha/beta hydrolase fold protein (Score: 65.6; E-value: 9.7e-20)" /gene_kind="biosynthetic-additional" /locus_tag="ctg13_19" /sec_met_domain="PF00561 (E-value: 7.5e-16, bitscore: 52.3, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 3e-09, bitscore: 31.6, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQK YQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMALEY ARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIANLPQDIDKDP ERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFAQIDLIQRLADVRM PVYIGLGRYDYMVAPVALWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFSKWLDQ " CDS complement(19544..21022) /gene_functions="transport (smcogs) SMCOG1202:major facilitator transporter (Score: 52; E-value: 7e-16)" /gene_kind="transport" /locus_tag="ctg13_20" /transl_table=11 /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRAI LLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGGIF IMFGHIALAYPGSAIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSIFYM GINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNVPNPL SKKSAIGTGIGVIIVAIAVIISVQTGVLTINRFIDLVSILGILIPVIYFIIMFTSKKAD STEKSRLAAYIPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWFQSLNPL FVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEALVSPLWLV LSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQVAGLFDKIP ETMYFGTIGLISIVLGGILLLLSPMIKRAMKGVL" CDS 21302..23056 /locus_tag="ctg13_21" /transl_table=11 /translation="MAEFILNAADFGVPGDGKTDSTERINQCLSTAVSKGYHTVWFPKG TYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQENIT ISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVSPRG LKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPKFGID IEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYGYGTQT VIKGNILRRPEDVAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRGKSVLVT NNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLNNCLIQVV DGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYSVSVTNNAG AIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIFDNTISVNRT AGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIFKGTINKHSSD TIDGNMIV" CDS complement(23071..23292) /locus_tag="ctg13_22" /transl_table=11 /translation="MKILGVTGVILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTTF AEWVVLLFFVLVLVREMYVIYKSKKKNP" CDS 23418..25052 /locus_tag="ctg13_23" /transl_table=11 /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNIA ETKKEVGSSSDVIIREIKIGEQDHVHLAVIYIAGLVDNNTIHESLIDPLVQDESIQNTH AIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSIQEP STQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQGICDE KVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLEGRFAI IVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVYVAATTF HQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSAVSIVGAL VIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASAVMGFYGLI LGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPESVSKEDKVRQ GKDQRPEPAASRGMVNKDLEEGDQNGT" ORIGIN 1 atcagctgac atagaagcac taaaatcagc actgaaggaa accctgccgg attacatgat 61 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtggaccg 121 caaagccttg cctgagccgg acattgaagc gggaagcgga gaatacaaag cgccgacgac 181 cgacatggaa gatctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 241 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 301 ccgcttgaac cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 361 cgaagagctg acccaatatg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 421 agagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 481 caagcaccac tggaaccaat ctgtgatgct tcacgccaag aagggctttg atcctgaacg 541 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctatcg 601 tgaggaaaac ggggacatcg ttcaggcgta taaaccgatc ggtgagagca aggtcagctt 661 cgaaatcgtg gatctgtacg gctctgatga agagatgctg agaagccaga ttaagattct 721 cgcgaacaag ctgcaaagca gtctcgatct gagaaccggg ccgcttttaa aggcggagca 781 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 841 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 901 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gactgggcgg aagaactggc 961 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 1021 tgaacaggtt tctcctttac cgaaggattg tgaaacagag cagcggatcg tcaaggatac 1081 atcatccgtc ctatgtgaat taacggaaga agacactaag catcttttaa cagatgttca 1141 tcagccatat ggaactgaaa tcaacgatat tcttctcagt gcgctcggtt tgacaatgaa 1201 agaatggaca aagggtgcca aaattggcat taaccttgag ggacacggcc gggaggacat 1261 catcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 1321 gctcgacata tctgacgcag atgcctcggc tgtgatcaaa acagtcaaag aaaacctgcg 1381 ccgcattccc gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 1441 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 1501 caaaaccgat ttctttgaac catccgcttt cgatatgggg cgccaagtaa gcggagaatc 1561 agaggcgctg tacgctttaa gcttcagcgg catgatcaga aacggccagt ttgtgctttc 1621 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 1681 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 1741 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 1801 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 1861 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 1921 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 1981 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 2041 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 2101 cgtattgaaa aaacggcagt tccaaataga agaaatcgat ctgacacact taacgggcag 2161 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 2221 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 2281 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 2341 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 2401 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 2461 ctggcgagag tatttagagg actttgaagg acaaacgacg tttgcggagc aaagaaagaa 2521 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 2581 ggcttttact gagcttgcaa aatcgcagca taccacttta agtacggcgc tgcaggcagt 2641 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggctttcg gtacagttgt 2701 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 2761 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcagct 2821 gcaggagcaa tcgctgcagt ctgagccgca ccaatatgtg ccgctttatg acatccaaag 2881 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 2941 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 3001 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 3061 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 3121 tctcacagca attcagcagc tcatccagaa tccggatcag cctgtcagca cgatcaacct 3181 cgttgacgac agggagagag aatttttgct aaccggctta aacccgcctg ctcaagctca 3241 tgaaacaaag cctctgacgg attggttcaa ggaagcagtg aacgtcaatc cggatgcgcc 3301 tgcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 3361 ccttgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 3421 gaagcgctca cttgaattgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 3481 tctgccagtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 3541 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 3601 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 3661 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 3721 gccaaaaggc aatatgacca ctcatgccaa tattcaaggt ttggtcaagc atgtagacta 3781 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgacgcatt 3841 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagacgaaca 3901 tacgctgctt gatacagaac ggctcacaga tctgattctg caagagaatg tcaatgtcat 3961 gtttgcgaca accgcactat ttaatcttct cacggatgcg ggagaggatt ggatgaaggg 4021 gcttcgctgt atattattcg gcggagagcg cgcctcagtg cctcatgtca gaaaagcgct 4081 gcgggtcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 4141 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgattggaaa 4201 gccgatcagc aatgccagtg tttatattct gaacgagcaa agccagctcc agccattcgg 4261 ggcgatcggt gaactgtgca tcagcggaat gggcgtgtca aaaggatatg taaatcgtgc 4321 tgacctcacg aaggaaaagt ttattaagaa cccgttcaag ccgggagaaa cgctttaccg 4381 cacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 4441 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 4501 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccctgagt ctggcgatgc 4561 atcaatcaat gcctaccttg tgaaccggac gcagctttca gctgaggacg tgaaggcgca 4621 cctgaaaaaa cagcttcctg cttatatggt gccgcaaacc tttaccttct tggatgagct 4681 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 4741 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatctg 4801 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 4861 gcattcctta aaggccatga ccgccgcttc ccgcatcaag aaagagcttg ggattgatct 4921 tcctgtaaag cttttatttg aagcgccgac gatcgccggc atttcagcgt atgtgaaaaa 4981 cgggggccct gatggcttgc aggatgtaac gataatgaat caggatcagg agcggatcat 5041 tttcgcattc ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 5101 gccgtcatac aagctgtgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 5161 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 5221 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 5281 gcggatcatc atggtcgatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 5341 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 5401 cgaagccgtc aaacaaggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 5461 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 5521 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgctt accgtatgaa 5581 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgccga 5641 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 5701 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacgcagc 5761 tcatctgttt tccgtttgcc ggcggctact cggcgtcgtt tcgccctctc catgcttttt 5821 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 5881 cagctattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 5941 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 6001 cgcaaaagct tgagcgtgaa ggcgtctttc cgcaggcggt tatcatttct gcaatccagc 6061 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 6121 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 6181 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 6241 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 6301 atgcggaagg ctggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 6361 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 6421 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 6481 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 6541 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 6601 atcggaatga actcattcag aaattccttt caatttttta tgttgccaat ggcggatgcc 6661 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 6721 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggca 6781 cttggagctg tctgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 6841 gtgttttccg ccatttacgg tgtgcttggc ggaatcggct attcctgcgc ggtcggcgtg 6901 acgacccagt acttcatcag ccgttggttt gacacacaca aaggtctggc gcttgctatt 6961 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 7021 tatcatgccg gctggcagag cacctatacg attttgggaa tcgtcatggc ggctgttctg 7081 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagtgga gtctgtgaaa 7141 aaattttatg attggcgggg gttttggaac gtgatgaagc aatcccgcct cattcatatc 7201 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 7261 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggcg 7321 tttatcatca ttggcggatt attggcgggc tggctgtccg atctcctcgg gagcagaagc 7381 gtcatgctat ccatcttatt tgtcattcgg ctgctcagcc tgatttgcct gctcattccc 7441 attctcggaa ttcatcacag cgaactttgg tattttggct ttattctgtt attcgggctc 7501 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 7561 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 7621 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttgctgat tgtcgctgtg 7681 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacaa 7741 aaggcaaaag aaacccacca atcaatataa aaggatcagc actgtcaatg ctgatccttt 7801 ttaaatttga gtttttttgt tccggtattt ttaaggataa tctccttgaa tctgtttatt 7861 tcctctttgg aatgaaaaaa acgttttggg atctcaatat attggccact tgatgtattg 7921 accctgaaga tatttttata ttcgaaaaca gctgtgattt catcccaatt gaaaatgagg 7981 tcatattttt tagaacatat acgaattcct tcttgattta gagtatatgt tcttttagat 8041 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag caggaggagc 8101 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa taagttaagc 8161 gcgtcactgc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 8221 gcgcaaaaca acagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 8281 cttacatcct taaaagcaat ttctcctgga agattgatac tttcattagc atattgaatc 8341 atacggtaaa cctacacctc taaccatgtt tttcctttca gtctagcata atttctcatt 8401 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 8461 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tctttgagaa 8521 tcacaactcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 8581 acgcctcaat tcgcgacagc gtatagttag acagaaacga agtaacaagt gaagacagca 8641 cgcccaaata cacaatgccg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 8701 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 8761 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 8821 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 8881 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 8941 aaaccgtgaa ccccttttgg gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 9001 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 9061 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 9121 tggcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 9181 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 9241 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 9301 ctatataagc gggggcttgc tgatgtttaa ccataatggg aatggctcct ttacctgaat 9361 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 9421 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctagt 9481 aacgaggata gaggagatga tgcaaagcac ctcctatcaa gaaggagaca ggcttccatc 9541 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 9601 ggagctggaa aaacgccacc ttatctattc cgttccgaaa agcggctact atattgtgaa 9661 aaagacggga aaagccaaaa gcgggcagcc tggccccatc gattttgcca catctgcgcc 9721 ggacccaaat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 9781 ttatttatgg gacgccaaag gggcttccat cactcatccg tgttctccga aagctcttgg 9841 ccactcaaca ggtatttgcg gatgaacggc atattttcat tacatcaggt gtccagcagg 9901 cgttatctct gctttgtgcc atgccatttc caaatgggaa agaaaagatc gccattgaac 9961 agccgggcta ccatttgatg gtcgaacagc ttgagacgct tgggattccc gccatcgggg 10021 tgaaacgaac ggaagaaggg cttgatatag ccggggttga gcggttattt caaacagaat 10081 cgattaaatt tttttatacg atgccgcgct tccataaccc gcttgggtgc tcattgtcag 10141 agcgtgataa acaggagctt gtgagactgg cagaagcgta tgatgtctac ctcgttgagg 10201 atgattacct cggtgatctg gaggaaaata aaaaggcaga tccgctgtac gcatatgatc 10261 tgtcctcaca tgtcatctat ttgaaaagct tctcgaaaat gatattcccc ggccttcgcg 10321 tgggggcggc tgttttgccc gaagcgctga ctgacacgtt ctatgcgtac aaaaaactga 10381 acgacatcga ctgttcgatg atttctcaag cggcattgga gatttacctg aaaagcggta 10441 tgtacggcag gcataaggag aaaatcagag attcttataa agagcggtcg ctgaggctac 10501 atcaagccat tcgaactcac aggcagctgg gaagcggacg ctttacgttc tccagcgggc 10561 aggcaccctg tatgcacacc catctggtgc ttcctcagga tctgcccgcc tcaagagtga 10621 ttcatagact gaaaaaacaa ggggttctcc ttgaggcgat agaccgtcat tatttatcag 10681 attatccgaa agaaaatcta ttaaaaatca atatttccaa tgtgaaaacg gaagatattg 10741 agcgcggtgt caagctgttg atgagccatt tataaaagct cttcgtacga gaccattgtg 10801 atatcctcgg ggaaatcagg gtgtgcggcg catacagcca ttttgtagcc gggatcgacc 10861 tcatacgttt tgatatagca tggggaatgg ctgtccggaa gctcaatgga tacttgtccg 10921 tcctggtgca ggcgcactga aaaagaatca agcggaagcg ataagccttt gccttcctgt 10981 ttgataaagc tttctttcat tgaccataga tgataaaaat agtctgtctg ctcgtccttg 11041 tcttttgcta aaaggtcgct gtactctgtt tttgaaaaaa agcgcttggc gatctcaagg 11101 ctgatcggtt tcgttttttc gatatctatg ccgatcggct gtgaatcaaa cgcaccaatg 11161 acccagcggc cggagtgaga aatgttgaaa tgagcgtcgg gaagatcagg gatgcacggc 11221 ttcccgtatt cctgcgtgct aaagcggata tcggatttgt ccaactgata ctgcctgctt 11281 atgactgagc gaacgagcac atctcccagc agggtgcggt gagcatcttc tttatgataa 11341 aatctccggc atttctcccg tttttcaggt gatatgaaag tcatgaaccg ttcattttct 11401 tcctgtgaaa gcgggcggtc catataaatt ccgtaaatct tcattctaga tcctccgtct 11461 gcaaaagatt gtcaaaacca tcctatcata cttccacaag actcatatag aggagaaaat 11521 aaaaaaacaa agccaaggcg gctttgtttt agtggacagg cggagatgct ttcacagcgg 11581 cggtccgcct tgccacagca taattcagca actggattga ctggggcaat gaaaagcgca 11641 aaataagtcc tgtgaggatg gcggtcaaaa tggtgccaaa accgatcggc ccgcccatgc 11701 cccatgccgc aaacaaaatg gttatttcca tgccgttccg cacccattgc acattccagc 11761 cggttttttc ggtaatcagc atcatcagtg aatcacgcgg ccccgcgcca agccctgctg 11821 atacataaac accgacgccg taaccgatca gcaccacgcc tagagagaag acgatgatcg 11881 agcctgtgta ggtcgagggg gcaggcagaa tgaaattgaa aaaatctata aatacaccaa 11941 tgagcaccat attcaggagg gccccaattt tcggccaagc tctcgtaaac aatgacgtga 12001 atccgacgat gagcgctcca ataatgatgg accactggcc gacggtaagc ccgaagtgct 12061 gaaacaggct gtaatgaaat gcatcccacg gactaatgcc gagtgctttt ccttctatcg 12121 tcagggatac accaaaagcc aaaatgatca aaccggcaaa ataaaatgtc cagcgcagaa 12181 caagttcttg cttcacgtga ggtcccttct ttcgtaaaaa tcagtcgatt gtcattgtag 12241 cacatctgac agaagggcgg aataggcgaa aggggcttaa caaaaaaaca gggccgccgc 12301 aggcgccctg tttcagcgtg ttggcaaacc cttgcattcg ttgtcaggcc tgttcttcgg 12361 tgctcacgaa tttaacattc gctgtgctcc aatgctcggc cttcctagac ttcaaaggtt 12421 ttcaatcacg ctgaaaatca caaaatccta aaacgaaaat cgttttagga ttttgtcaat 12481 aatctgaaac agggcgcagg cgccctgttt ttcttattac agcgggttca aaatccggtt 12541 caagaaccgc tgtgtccgtt cttcttttgg tgcggagaaa atttgctccg gcggtccttg 12601 ctccacgata acgccgccgt cgatgaagat gacttcatcc gcaacttcct gcgcgaactt 12661 gatttcgtgg gtcacgacga ccatggtcca gccttcattg gccaagtttt tgataacctt 12721 cagcacctct ccgacaagct cgggatcaag cgctgaggtc ggttcgtcaa acagcatgag 12781 ctcaggctga atcgccagtg cgcgggcgat gccgacgcgc tgctgctggc cgccggaaag 12841 ctggaacgga tataaatcca ttttgtcctt caatccgact ttatcaagaa gctgaatcgc 12901 ttcttttctg acttcctctt tgttccgttt ttgcacctga atagggccct ccatcacgtt 12961 ttcgagggct gtgcggtgcg ggaacaggtg atacgcctga aacaccattc cggattttcg 13021 gcgaagcttt aggatatccg cctgtttcac ctttttagag aaatcgatgg agaaattatc 13081 aaatgcaagc tctccgcgat tcgggatctc cagagcgttc aggcagcgaa gcagcgtcgt 13141 tttccctgaa cctgaaggcc caagtatggc gatgactttt cctttttcaa tcttcatatc 13201 tatctttttt aaaatttcat tttcaccgaa tgatttgttt aatcctttaa cggtaagcat 13261 actcggaacc tccttatttg gccacgtagc ggtcaagacg ccgttcgatg acatgctgga 13321 cgagtgagag caggaagcag ataatccaat aaataaaggc tgcttcaata tagatcacta 13381 aaatttgatc aagattccgc gcgccgattt cctgggcttt tctgaacagc tcagcgacca 13441 gaatttgaga ggcgagggat gtatctttaa tcaggctgat aaaggtattg gataatggcg 13501 ggatcgacac acgaaacgcc tgcggcaaaa tgacgcggaa cagcgttttt tgatgtgtca 13561 tgccaattgt gtagccggct tcccattgcc ctttcggcac ggataaaata gatgcccgaa 13621 tgatttcaga tgcataggcg ccgacgttta aagaaaaggc gataactgcg cttggaaatg 13681 gatctaatgt gacgttaaag gccgggaaca gatagaaaat gatgaacaat tgaacgagaa 13741 gaggagtgcc gcgtattgcg gatacgtata cgctgaacac ccatctcaaa ggtctcactt 13801 tcgacattct ggcaagcgcc gtaatcagcg ccaggatcat tccgaatata aaggaaagaa 13861 tcgtaagggg aatcgtatag tagattcccc ctgaaagtat cggccagaat gactgctgca 13921 ccagatccca cgggatcgcc gtgccaagcg tcaatgccgg cagattattt agaaacatct 13981 tcgccgaacc attttttaga tattttagaa agagtcccgt cctctttcat ttcttttaat 14041 gctttgttga cttgatcaac aacctcgccg cttcctttac ggaacgtgaa atatgttgac 14101 tgaggatcac ctgtttcaaa cgcgattttc acgtttttat tgccagatgt ttttaagtag 14161 ttcaatacgg caagcttatc gttgtatgtc atatcgacgc ggccttgctg gatcatttga 14221 agggcctgcg ccataccttc aacgccttct actttagcgc cggcatttgt agctaatttg 14281 ttgtagttgc ttgtcagtga ttgagctgac gtttttcctt ttacatctgc ttcagactta 14341 atatcgttgt tgtctttttt cgttacgaca acggctcttg atgttgtgta tttatctgag 14401 aaatcatatt tgtcttcacg atctgttttt ccgacttggt tggcaacaac gtcaaaccgt 14461 ttggaattca ggccggcaaa catactgtcc cactgtgttt ccttaaagtc gactttaagc 14521 ccgaggcgtt ttgcgacttc tgtgataact tcgacatcat agccagtcaa tttatcagtg 14581 tctttgtcgt ggtaagtgaa cggctcatat gttccttccg ttccgactgt gagcacacct 14641 tttttcttaa ttgaagccca aagatcgcca tctttggcat tatcttttga ctgattgtca 14701 tttcctgctc cgcaagctgc aagagctgca atacttacga ccatgaataa agccaataat 14761 gcttttttca tcttattccc cacttttctg gttgatttta ttgaaataaa aaaatagctt 14821 acaaatctaa aggataactt ttttttagta tgagtcaagt aattggtttt cataaggcaa 14881 aatcttttaa aataaatcca aaaattgctg tgccggttta ggcaaataac tgtccgttct 14941 ccacatgaca gccggtgtca taatgaaggg attattttcg atatggacgg tgtgaacgtg 15001 atttctcata tgaacgggaa tcattgtgac gggcaaaata gacgcgccga atccggatga 15061 cacgaggctg agcaaagttg cagagtcgtg gcattcacaa acaatgcgcg gctccaggtt 15121 caaacgatga aattcattca tgacctgatt atagacgcct tttccgttga caggccgcag 15181 caggatcagc ggaaatgaag gaatgtcctc catcttaatg gtgtctccgc acggatatcc 15241 ggcttcgtct gaaagcacga gcacacatgg aatgtcatca agctgcttga attgtactgt 15301 gtcacttttg atcagtgttg tcgtgaccgc ggcatcgatt tgacggcttt ccagcagctc 15361 taacagcgtc gcgggctcat tttcccaaat gttaaaggtg aggtgcgggt atctctcttt 15421 gatttgtgtt actttttcga gcatcaaagc ggcgcaataa atcgttgaac ctacggccag 15481 cgtgccggct acctcctcct tcagctcttg tacctcaatg acggcatcct caaacctgtg 15541 cagaatctct tttgctcttt ttagaaaaac agctccttca tatgtaagag tcatttgttt 15601 tttcttgttc cggtcaaaca ggacaacacc aagttcgtcc tccagctgtt tgagctgcct 15661 gcttaaaggc ggctgcgcca tgtgaagctt tttggctgcg gacgtgattt tctgttcttg 15721 ggcaatggta atgaagtatc gaagctggcg aatatccaaa agaaagcgcc tccttatcat 15781 accttttagg tattaaatat agatttaata gatatttttc atatggatat atcaggagta 15841 tgattgaaat gaaagcagaa ttcaagcgta aaggaggggg caaagtgaaa ctcgttgtcg 15901 gaatgacagg ggcaacaggg gccattttcg gggtcaggct gctgcagtgg ctgaaggccg 15961 ccggagtgga aacccatctc gttgtgtctc cttgggcaaa cgtcacgatc aaacacgaaa 16021 caggctatac cttacaagaa gtagaacaac tggccacata cacctactca cataaggatc 16081 aggcggcagc catttcaagc gggtcgtttg ataccgatgg aatgattgtt gcgccgtgca 16141 gcatgaaatc tctcgcaagc attcgcaccg gaatggcgga taatctgctg acacgtgcgg 16201 cggatgtcat gctcaaggag agaaaaaaac tcgtcctctt aacgagagag acgcctttga 16261 accaaattca tctcgaaaat atgctagcgc ttacgaaaat gggcaccatc attcttcctc 16321 cgatgccggc attttataat cagccgagaa gcttagagga aatggttgac catattgtat 16381 tcagaacgtt ggaccaattc ggcattcggc ttcctgaagc gaagcgctgg aatgggattg 16441 aaaaacaaaa aggaggagct tgatcatggc ttatcaagat ttcagagaat ttctcgctgc 16501 ccttgaaaaa gaaggacagc tgcttacagt gaatgaagag gtaaagccgg aaccggattt 16561 aggggccgcc gcacgggcag ccagcaatct tggcgataaa agccctgcgc tcttatttaa 16621 caacatttac ggctatcata acgcgcgaat tgcgatgaat gtcatcggct cttggccaaa 16681 ccatgccatg atgctgggca tgccgaaaga cacaccggta aaagaacagt tttttgaatt 16741 cgcaaagcgt tatgaccagt ttccgatgcc ggtcaaacgt gaggaaacag cgccatttca 16801 tgaaaatgaa atcacagaag atatcaattt gttcgatata ctgcctcttt tcagaattaa 16861 ccagggtgat ggaggctact atttagacaa agcatgtgtc atttcccgtg atcttgagga 16921 ccctgacaac ttcggcaaac aaaatgtcgg catttacaga atgcaagtca aaggaaaaga 16981 ccgccttggc attcagcctg tcccgcagca cgatattgca atccatctgc gccaagctga 17041 agaacgcggc atcaaccttc cggtcactat tgcgctcggc tgtgagccgg tcattacaac 17101 ggcggcatcg actccgcttc tctatgatca atcagaatac gaaatggcag gtgcgattca 17161 aggcgaacca tatcgcatcg tcaaatcaaa gctgtctgat cttgatgttc cgtggggcgc 17221 tgaagtggtg cttgaaggtg agattattgc cggagagcgc gaatatgaag ggccgttcgg 17281 tgaattcaca ggccattatt ccggcggacg cagcatgccg attatcaaaa ttaaacgcgt 17341 ctatcacaga aacaatccga tctttgaaca tttatactta ggcatgcctt ggacagaatg 17401 cgattacatg atcggcatta acacatgcgt gccgctttat cagcagttaa aagaagcgta 17461 tccgaacgaa attgtggcag tgaacgccat gtacacacac ggtttaatcg cgattgtttc 17521 cacaaaaacc cgctatggcg gatttgcgaa agcggtcggc atgcgcgcac tcacaacgcc 17581 gcacggactc ggctactgca aaatggtcat tgtcgttgat gaggatgtcg atccattcaa 17641 ccttccgcag gtcatgtggg cgctttcgac caaaatgcat ccgaaacacg atgcggtcat 17701 cattccggac ttatctgtcc tgccgcttga tccgggatcc aatccatcag gaatcactca 17761 caaaatgatt cttgacgcca ctacaccggt tgcgccggaa acaagaggcc attattcaca 17821 gccgcttgat tctccgctaa caacgaaaga atgggaacaa aaactaatgg acttaatgaa 17881 taaataagga aaggatgttc gaaatgcata catgtcctcg atgcgactca aaaaagggag 17941 aagtcatgag caaatcgcct gtagaaggcg catgggaagt ttatcagtgc caaacatgct 18001 tttttacatg gagatcctgt gaaccggaaa gcattacaaa tcccgaaaaa tacaatccag 18061 cgtttaaaat tgatccaaag gaaacagaaa cagcaattga agttccggcg gtgccggaac 18121 gaaaggcttg atcggcgtga acagtatgtc agaccgtctc tttgagctgc ttgacgggag 18181 atgcctgaat gagaagcagc atgaggcctt cgttctgcaa acagtatcag aggatggctg 18241 gccgcatgcc gctatgatca gtgcgggtga aattatcgcg ctgagccgaa ctgatatccg 18301 aatcgctctg tggaaaaaca caatgacttc ggccaacatc cttcgcacag gaaaagcaca 18361 gttcacggcg tggtggaagg gagcggccta ttatgtaaag cttgaatgcg cgcctttacc 18421 gcctttgaaa gatgccgaat atgatagaga ccgtttttcc tgccgcatcg tttcagtgaa 18481 ggaggacgtt gcgaaatacg ctgatttgac ttcaggtgtc cgtatacagc ttcacagccc 18541 tgaagaggtg ctgggcagat gggaaaagac cctggaagat ttaaagcggt aatatcgata 18601 gcctgacgcc atgcgtcagg ctttttttat ataatgaaaa caaagggggc gtgagaaatg 18661 gaacgtgcgg ggatctgtca ctcggacggc tttgatttag cttatcgaat tgagggcgag 18721 ggcgcaccca tccttgtgat cgggagtgcg gtttactatc cgcgcctttt ttcctcagat 18781 atcaaacaga aatatcaatg ggtctttgtc gaccataggg gatttgctaa gcctaagcgg 18841 gagcttcgtg cggaggattc gaggcttgat gccgtcttgg ctgatatcga aaggatgaga 18901 acatttcttc agcttgagga tgttactatc ctgggacatt ccgggcacgc ttttatggct 18961 ttagagtatg ccaggacata tcccaaacaa gttcggaagg tggcgctctt caatactgcg 19021 cctgataaca gtgaagaaag acagcgaaaa agcgaatcat ttttcatgga aacagccagc 19081 cttgagagaa agaaacgatt tgaaaaagac atcgcgaatt tgccgcagga catcgacaaa 19141 gatcctgaaa ggcgctttgt gcacatgtgt attcgcgctg aagcgaaaag cttttatcaa 19201 gagcggccgc atgcagctgc cttatgggac ggtgtattca cgaatatgcc gatcattgat 19261 gaattatggg gcaatacatt tgcccaaatt gatcttattc agcggttagc tgatgttcgt 19321 atgccggtgt atatcggatt agggagatat gattatatgg ttgcgcctgt tgcgctatgg 19381 gatgctgttg acggtttata tccccatgtg gataaggtta tttttgaaaa gagcggccat 19441 cagccgatgc tggaagaacc ggaagccttt gatcaaagct tcagcaaatg gctggatcaa 19501 taaaaaaaca gcccgcagat taaaatccgc gggctgtttc taattataag acccctttca 19561 tcgcgcgttt gatcatcggc gagagcagca ggagaatgcc gccaagaacg atagaaatca 19621 aaccgatggt gccgaagtac attgtttcag gaattttatc aaacaatccg gctacttggg 19681 cattgatcgc ttgtgctgct gcgttcgtca gaaaccacat actcattgtc tgtgcagaga 19741 aggcagctgg ggccagtttc gttgtcacgg ataaaccgac tggagacagg cacagctctc 19801 caagcacgac aagcaggaag ctgagaacga gccaaagcgg gcttacgagt gcttcttttc 19861 cttgcatagc agggaatacc ataatgataa atgacaatcc ggctaaaata attccgattg 19921 agaatttaac tggtgtagac ggctggcgtt tgccaagctt catccagagc catgcgaata 19981 ttggcgcaaa aatgacgaca aacaatggat ttaatgattg gaaccatgat gattgaagtt 20041 cgaatccgcc caatgaaagt cttatgcgtt catcagcgta taccgcaaga atggtcgctc 20101 cctgttcctg aatggcccag aacatgacag caccgataaa caaaggaatg taagcggcaa 20161 gacgggattt ttctgtgctg tccgcttttt tgcttgtaaa catgatgatg aaataaatga 20221 caggaatcaa aataccgaga atacttacaa ggtcgataaa acgattgatc gtcagcacgc 20281 ctgtttgtac agagataatc actgcgatcg ccacgatgat aacaccgatt ccggtgccaa 20341 tcgcagattt tttagacagc ggattcggca cattggaacc tgcaagcccg aggtttttct 20401 ttcttgtcaa agcaaaaacg ataagtccga gaagcattcc gaccgcggca gctccgaagc 20461 cgagatgata gttgtacttc tgtccgagtg ttccgacaat taacggtgca agtaaaccac 20521 cgaggttaat ccccatgtag aaaatactga aacctgagtc gcggcgcggg tcttctttcg 20581 tgtaaagatc cccaaccacg cttgaaacgt ttggttttaa taatcctgtt ccgacaataa 20641 taagcaccat gctgatatag aatgcgatcg cgctgcccgg ataggcgagt gcaatgtggc 20701 cgaacataat gaatatgccg ccgtaaaaca cggtgtttgc ggtaccgaat acccggtcag 20761 cgagccatcc gccaataatg gtggacatgt atacgagtga tccgtaaatc gacataatgg 20821 caaccgcagt gcccttgtca aagccgagcc ctccgtttac cgtctctgta tacaaatagt 20881 aaagtaagat tgctctcatt ccatagtaag agaaacgctc ccaaaattcg gtgaaaaata 20941 gtgtaaatag tcctcgcggg tgaccaaaga accctttttg cgggacgctt ttaatgatac 21001 tttcgttatc aatcgaagcc atgtcagcca aaccctttct aaaaaaagtg tattataaaa 21061 atcatattct tatataatac ttgtgtcaat ataatttata ctcatttcaa atagttccat 21121 aatggaaaaa ttataaatac ctaaaaatag tgatttcctc ctaattttta aactttttat 21181 cgtgagattt tcttacacaa ctattccttt atattttttt aataaaattt tagagaaatg 21241 tacaagcaga tcgggccttt gtgagtaaca tgatagtaat catagagaag gaggctcgca 21301 attggctgaa ttcatattaa atgcagcgga tttcggtgtt cctggagatg gtaaaacgga 21361 ttcgacagaa cggattaatc agtgcctcag tacagctgta tcgaaaggct atcatactgt 21421 ctggtttcca aagggaacat atttaataga cgcaacgctt ggcggagatc ttaatcagag 21481 gtttcgaaac gcggggatca ttgttcccgg caaccttgag attatgatgg accccgaatg 21541 tatcatgaaa gtgatcccga atagttcgtg gggttattcc gcattttatg tgggcaagca 21601 agagaatata accatttccg gaggacaaat tatcggcgaa cgggatgagc atacgtatgc 21661 ctcggcaggg ataaggtcaa cccatgaatg gggctttggc atatgtattg aaggatgctc 21721 gaatgttgtc attgatgatg tgaaaatttc tgattttacc ggcgatggga tcatagtcag 21781 cccaagggga ttaaagacca atcaagatta tcgaacgtca gagcaaatta tcatccgccg 21841 ctgtgaggtt cggcggtcga ggagaaataa catttccatt accggatgtg acatggtcac 21901 ggtggaggaa tgcttgattg aagatgccgg aacggggaat ggaacagcgc cgaaattcgg 21961 aattgacatt gaaggatatg gcgaaggtga cgttgattat gaggaaccga ttaatgtatc 22021 aattcgcaat aaccactttg ttggaaacgt ttcaagttct gtgaccaatt ttaacgggta 22081 tggcatttta atagaaggaa atcactctga caatacaatc agctacggat atgggacgca 22141 aacagtgatc aagggaaata ttctgagacg ccctgaagac gtggcggctg cgccaagagt 22201 cgggataacc ggactcggtg tatcacaagg aaaagagacc agtgatgcag tgatcgctgg 22261 caacctcatt accggatttt caactggaat tgatgtcagg ggaaagagcg ttcttgtgac 22321 gaacaacaaa atcagcaact ttgaaaacac agggatattg gtttaccagt cttccgacgt 22381 aaaggtagac ggaaaccaaa ttcaaaacgg actgtctgaa acaaggcgca gcatcggtct 22441 tcgcgcagtg ctgtcagatg acatcgcttt tctgaataac tgtctcattc aagtcgttga 22501 cggtgtgaac gtttccggcg gaaatatgat cattaaagat aatctcctga gaaaattcag 22561 ccggggcatt tggattgctc aagggaacgc ggtgattgaa gggaatacac tgaatcctga 22621 cgcgtttgaa gcagtgccgg aatcatattc tgtttccgtc acaaacaatg ccggcgccat 22681 catcaaaaac aatacattta aagagttcaa aaattacccc atttattgct ccacaagtgc 22741 gaaaacctca attatcggca accacttaga gagatctccg cttttggtca ccatctatat 22801 cagcgccggt gtgcatgaga tttttgataa taccatttca gtcaacagaa cagccgggaa 22861 tccgattgtg atttatctca atggctctgc aggctctatc atctcaggaa acaccatcaa 22921 taacctctcc gcgggcactg cgacagctat tcaaacaaac acgtcaacca attccaaaat 22981 catcggcaac cgcattttta aagggactat caacaaacac agcagtgata caatagacgg 23041 caatatgatc gtctgaaaaa agcgccccct ctaggggttc ttttttttcg atttatagat 23101 cacgtacatt tctctcacaa gtactaacac aaaaaataaa agcacgaccc attccgcaaa 23161 tgttgtcatc ttaaagctgg acatattgtt ataaacggct tttgttaaac tgaacccttg 23221 aagcatgtcc atcaatacag aaatagctaa taaacaaatt aatatgactc cggtcacgcc 23281 caatatcttc atgcttcatc atcctccgct tttagtgtct atcgttggcg gagaagttat 23341 accgcatcta accctaatgc ataatctcaa ttttaaaagg aagaatatga gaaaacgaca 23401 aggaaaggta tttgtgtatg cctttatttt ctaagcgaaa gaacaatacc gattcaaaag 23461 acaagcagaa tacagacgaa aggaatcagg aacagcagca agaaaaagaa aggccggttc 23521 tcatttctcc aagtttggca aagaatatag cggaaacgaa aaaggaagtc ggaagcagct 23581 ctgacgtcat cattcgcgag attaaaatcg gggagcaaga tcatgtccac ctagctgtta 23641 tctatattgc tgggctggtc gataataaca cgatccatga gtcgttaatt gacccattgg 23701 tacaggatga gtctatccag aatactcatg cgatccagca aattcttgaa aaaacgctcc 23761 cgctgggcgg ggtgaaagcg gaaaagagct gggacaagct tttttccgag ttaatgctcg 23821 gcaatgcgct catttttgct gatggccatg atgaagcttt gatttgcagc actcaagggg 23881 gagagcagcg ctccatccaa gagcctagca cccaggtgtc attccgcggc ccgcgccaag 23941 ggtttacaga gtctctgcaa accaatattt ccatgatccg gcgatacatt aaaaatccga 24001 atttatgggt tgaaaaaatg aaaaaaggtt ctgttacgaa tacggatatc gctctcatgt 24061 acattcaagg aatatgtgat gaaaaggtgc tgaaggaagt gaagcagcgc ctggaaaaaa 24121 tagatattga cagtattttg gaatctggat atattgagca gctgattgaa gatgaaacct 24181 ttacgacgtt tccgactatg tatcatacag aacgccctga tgttgtagcg ggtaatctgt 24241 tagaaggaag attcgcgatt attgtggacg gaacaccgtt tgtgcttatt gccccggcct 24301 tatttgtcca gttttttcag tctgttgagg attattattc gcgttttgac attgcgacaa 24361 gcataagaat tcttcgtgtt ttagtctttt tcatttcgct tgtggcaccg gctgtatacg 24421 tggcagccac gacgtttcat caagaaatga taccgactca gctgttagtg gtcattgccg 24481 cccagcggga aattgtcccg tttccggctg ttgtggaggc gctgacgatg gaggttgctt 24541 ttgagattct gagggaagcg ggagtcaggc tgccccgggt tgtcggctcg gcagtgtcaa 24601 tcgtaggcgc gctcgtaatc ggccaggctg ccgtacaggc tggtatcgtc tctccggcaa 24661 tggtgattat cgtggcactc accgcgattg cgagcttcgc aacaccggcg tttgcaatgg 24721 cgatttcagc ccggcttatt cggtttatct ttattattgc ctcagctgtt atgggttttt 24781 acgggctgat tttagggatc attatgatgt ttgtccactt atgcagtctt cgttcattcg 24841 gcgttccata tatgtcgccg cttgcacctt tttcttcaca aggcgtaaag gacgcgcttt 24901 tccgggttcc gtggtgggcc gatgaaaaaa ggccggaatc ggtcagcaag gaagataagg 24961 tgcggcaggg gaaagaccaa cgcccagagc cggccgcttc acgaggaatg gtgaacaaag 25021 atttggaaga aggggatcag aatggtacgt aaatgtctat tagccgttct catgcttttg 25081 agcgtcattg tgctgcccgg ctgctgggat aagcgggagc tgacggatct tgcgattatc 25141 tcggcgattg gcatcgatcg gacaaacgac agcaactacg tgctgcatct tcaaattatc 25201 aatccaggaa atgttgccgg cggccttcag ggaggcggtg ctggagacag gccgcctgta 25261 tctgtctatt cgattgaagg taacaatata acggaagcac tcagaaaagc ctccatgaag 25321 gtatcacggc ggctttattt tgcccatacc aatctagtcg tgatcaatga aaagctggca 25381 aaagaagaag gtttggattt tgtattagat aatcttgacc gggacacaga attcaggaca 25441 acagcaacat tcgtcgttgc ccataaaaca aaagcagaaa atattgtgaa aatcttgacg 25501 ccgattgata aaattccgtc aaataaagtc aataaaacac tcgatttcac ggaggcacaa 25561 tacgggcggg tggtcaaaat caatattcag gacgttttga aaacacttgc cgccaacact 25621 atggcaccgg tcatccccgg atatatgatg attggtgacg ataaaaaagg agtcagcatg 25681 gaaaac //