LOCUS       gnlProkkaGPJOEOKK_37   14343 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GPJOEOKK_37.
ACCESSION   gnlProkkaGPJOEOKK_37
VERSION     gnlProkkaGPJOEOKK_37
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 18:10:36
            Original ID  :: gnl|Prokka|GPJOEOKK_37
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14343
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14343
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2923:10807]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2924..10807
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..14343
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14343
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             complement(381..1322)
                     /NRPS_PKS="Domain: PKS_ER (11-220). E-value: 3.1e-12.
                     Score: 38.1. Matches aSDomain:
                     nrpspksdomains_ctg24_1_PKS_ER.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 199.9; E-value:
                     8.8e-61)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_1"
                     /sec_met_domain="ADH_N (E-value: 1.7e-12, bitscore: 37.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.4e-22, bitscore:
                     69.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEDALGPRENIILGHEACGVVVEVGEDVKDFKPGDRVLVPAITP
                     NWSDVYSQAGYATDSDGMLGGWKFSNIKDGVFATRFHVNDADGNLAHLPDEIDPTEACM
                     LSDMIPTGLHASEMAGVTFGDAVAVIGIGPVGLMALRGAVLHGAGRVFAVGSREKTVEV
                     AKKYGATDIIDYHNGRISDQILEATGGQGVDKVLIAGGNAKDTFEEAVRMLKPGGSIGN
                     VNYLNGHDDVVFNAGDWGVGMGHKTIHGGLMPGGRLRMEKLAVLVVNGRIDPSLMITHR
                     FEDFEKIPDAIELMHHKSADLIKPVVICNDID"
     aSDomain        complement(663..1289)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg24_1_PKS_ER.1"
                     /evalue="3.10E-12"
                     /label="ctg24_1_PKS_ER.1"
                     /locus_tag="ctg24_1"
                     /protein_end="220"
                     /protein_start="11"
                     /score="38.1"
                     /tool="antismash"
                     /translation="IILGHEACGVVVEVGEDVKDFKPGDRVLVPAITPNWSDVYSQAGY
                     ATDSDGMLGGWKFSNIKDGVFATRFHVNDADGNLAHLPDEIDPTEACMLSDMIPTGLHA
                     SEMAGVTFGDAVAVIGIGPVGLMALRGAVLHGAGRVFAVGSREKTVEVAKKYGATDIID
                     YHNGRISDQILEATGGQGVDKVLIAGGNAKDTFEEAVRMLKPGGSI"
     CDS_motif       complement(858..884)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg24_1_0002"
                     /evalue="5.50E+00"
                     /label="PKSI-ER_m2"
                     /locus_tag="ctg24_1"
                     /protein_end="155"
                     /protein_start="146"
                     /score="0.8"
                     /tool="antismash"
                     /translation="GAGRVFAVG"
     CDS_motif       complement(1245..1283)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg24_1_0001"
                     /evalue="6.30E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="ctg24_1"
                     /protein_end="26"
                     /protein_start="13"
                     /score="9.6"
                     /tool="antismash"
                     /translation="LGHEACGVVVEVG"
     CDS             complement(1333..1452)
                     /locus_tag="ctg24_2"
                     /transl_table=11
                     /translation="MKGFAMLGPNKTGFIEKEDPKVGSRDALVRPLAVAPVYF"
     CDS             complement(1683..2873)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 231.1; E-value: 2.9e-70)"
                     /gene_kind="transport"
                     /locus_tag="ctg24_3"
                     /transl_table=11
                     /translation="MDAKPNRRALSLGSFVILYLGYMLLFADRTVLNLSLAAIGKDFSV
                     SPAALGATSSVFFLGYTIMQIPGGWLTDRFSSRKVIIATLAFWSVMTIFTGLAWSLAAL
                     LVIRFLFGIAEGPYPPAAMKQVAQDFPVNKRAQLTAALISSNYAGAALAPFIIVPIIAA
                     TGWRSAFFWLGGFGLLLMVSYLFFRGHGGGQTVTKQERQKINWKEIDPRVWAFVVIGLA
                     LNIITKGMETWMPVYFLNARHINLANLAWLVPLPTIAGGIAALISGYVMVHIFKNHERL
                     MIILASFLTVLTMFGLYKSTSLVWLVIFQMATYFVKSLAFTGIFSYAAQLFPQKTYGSQ
                     IGTINFGGQLGGFFGPLLIGWIVQLSGSYDTAFFGLVISALVAGVASLFVGNLKAK"
     CDS             complement(2924..4348)
                     /NRPS_PKS="Domain: AMP-binding (8-379). E-value: 2.4e-71.
                     Score: 232.3. Matches aSDomain:
                     nrpspksdomains_ctg24_4_AMP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     305.9; E-value: 7.2e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_4"
                     /sec_met_domain="AMP-binding (E-value: 9.7e-76, bitscore:
                     244.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEITNWLLKQASLNPNRVAVNDGTTAYTFAQLVPLVAHRAGQIQA
                     QTDQPRVGVMTHNNLAGYLAALGVLAADKTIVWLNWRLAPEELSRQIGDAGLDLVLVDD
                     QLADRYYGGHRVLCSELTAGTAPAAVLTKTVDLDAVASIMYTSGTTGQPKGVLQTYGNH
                     LASAISSSLNLGVLPNDLWLCVAPIFHISGFSILMRGLIYGMGVRLVNHFDAQVVNQIL
                     EDEPVTIISAVPYMLKKMLEDVQANDHCYSSAFRLVLLGGGTIDRATLNACEESGLPVV
                     QCYGMTETCSQFVALSAEEAPYHLGSVGKPLFTTQLRLVGEHHEIEIQTPALTPGYLNQ
                     PAKFAAKHDGDWYRTGDVGHFDEDGFLYVDGRLDEMIISGGENIFPAEVENVLRQYPGI
                     QEIAVVGRNDQQWGAVPVAVVVSKQPVDFQQLEAFGREHLAHYKVPKVYLQTDALPKNA
                     SGKVQKFRLQDLVANA"
     aSDomain        complement(3212..4324)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg24_4_AMP-binding.1"
                     /evalue="2.40E-71"
                     /label="ctg24_4_AMP-binding.1"
                     /locus_tag="ctg24_4"
                     /protein_end="379"
                     /protein_start="8"
                     /score="232.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="KQASLNPNRVAVNDGTTAYTFAQLVPLVAHRAGQIQAQTDQPRVG
                     VMTHNNLAGYLAALGVLAADKTIVWLNWRLAPEELSRQIGDAGLDLVLVDDQLADRYYG
                     GHRVLCSELTAGTAPAAVLTKTVDLDAVASIMYTSGTTGQPKGVLQTYGNHLASAISSS
                     LNLGVLPNDLWLCVAPIFHISGFSILMRGLIYGMGVRLVNHFDAQVVNQILEDEPVTII
                     SAVPYMLKKMLEDVQANDHCYSSAFRLVLLGGGTIDRATLNACEESGLPVVQCYGMTET
                     CSQFVALSAEEAPYHLGSVGKPLFTTQLRLVGEHHEIEIQTPALTPGYLNQPAKFAAKH
                     DGDWYRTGDVGHFDEDGFLYVDGRLDEMIIS"
     CDS_motif       complement(3878..3928)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg24_4_0001"
                     /evalue="4.30E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg24_4"
                     /protein_end="157"
                     /protein_start="140"
                     /score="22.4"
                     /tool="antismash"
                     /translation="ASIMYTSGTTGQPKGVL"
     CDS             complement(4358..5179)
                     /NRPS_PKS="Domain: ECH (18-261). E-value: 2.8e-63. Score:
                     205.3. Matches aSDomain: nrpspksdomains_ctg24_5_ECH.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 198; E-value:
                     2.4e-60)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_5"
                     /transl_table=11
                     /translation="MTSANWTPVKEYSEIIFERDDKIAKITMNRPEKHNAFTPVTVAEM
                     IDAFNICRDDSTIGVIILTGAGDKAFSSGGDQSVRGNGGYVGPDHIARLNVLDLQHLIR
                     IIPKPVIAMVKGWSVGGGNVLQLVCDLTIAADNAMFGQTGPKVGSFDAGYGSGYLARVI
                     GHKRAKEVWFLNHFYTADEAYQMNWINKVAPLAEVESVTLDWCHEILKKSPTALRFIKA
                     AMNADTDGLAGLQQFAGDATMLYYTTDEGKEGRDAFNQKRDPDFDKFPKFP"
     aSDomain        complement(4397..5125)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg24_5_ECH.1"
                     /evalue="2.80E-63"
                     /label="ctg24_5_ECH.1"
                     /locus_tag="ctg24_5"
                     /protein_end="261"
                     /protein_start="18"
                     /score="205.3"
                     /tool="antismash"
                     /translation="RDDKIAKITMNRPEKHNAFTPVTVAEMIDAFNICRDDSTIGVIIL
                     TGAGDKAFSSGGDQSVRGNGGYVGPDHIARLNVLDLQHLIRIIPKPVIAMVKGWSVGGG
                     NVLQLVCDLTIAADNAMFGQTGPKVGSFDAGYGSGYLARVIGHKRAKEVWFLNHFYTAD
                     EAYQMNWINKVAPLAEVESVTLDWCHEILKKSPTALRFIKAAMNADTDGLAGLQQFAGD
                     ATMLYYTTDEGKEGRDAFNQK"
     CDS             5214..5597
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144:thioesterase superfamily protein (Score: 97.2;
                     E-value: 9.8e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_6"
                     /transl_table=11
                     /translation="MNLLENLGIHQDLVTKDRVELSMPVQAKHLQPYGIVHGGINTVLA
                     ETAASLGANANVAPGRIAVGVNVTTQHIRAIREGEIFVVATPDHVGHTLQTWQARLLVN
                     DRLTATATITLMNVPAPTNNHKH"
     CDS             complement(6007..6384)
                     /locus_tag="ctg24_7"
                     /transl_table=11
                     /translation="MTNDINFWTGIKDPYLKPDKPFLTEDKELKIIHLIQSYPMHCPLY
                     GQLMRRNGFRKRPVTIKILTPAGKPAVLKIKKQQYLCPPSPQCPKRVTKVAEIQGVNFA
                     CRIANVVKYHIVQELSESVRN"
     CDS             complement(6597..7355)
                     /locus_tag="ctg24_8"
                     /transl_table=11
                     /translation="MMYEFPRLTAHHIQTTDQPVVTSTNEMAKERLKVKDQPFLISARQ
                     QTAGHGKTSRKFYSPAGSGAYFTLALPFSYLAKSAGQVTVTAAVAAYEVLSKQFTVPIT
                     IKWVNDLYCERKKVVGILAEMEMTANNQPRGIVVGWGINLAAPTVPLPPALQLRAGWLG
                     TTSIDDHQRLQIVDAVAAHFLDLLANASWKHILQVYQTHQYLINKLLLVDTGAGRVRGY
                     FDHITDDGWLCVQTDNGPRAFMTGTVRELV"
     CDS             complement(7370..10807)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     92; E-value: 5.7e-28)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_9"
                     /sec_met_domain="ATP-grasp (E-value: 9.9e-12, bitscore:
                     34.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.4e-11,
                     bitscore: 33.3, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="HMGL-like (E-value: 2.9e-36, bitscore:
                     115.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKKVLVANRGEIATRIIRACHELGIKAVAVYAKEDEYSAHRFAA
                     DEAYQIGAGEHPLDAYLDIDEVIRVAKESGAEAVHPGYGFLAENADLAQACIDNGLKFI
                     GPKPEHLRMFGDKLVAKRVAVEAGLQPIPGLSGDVKNVDQVKDFAHQYGYPIMVKAANG
                     GGGRGMRIINDDQQLTDEFDQAKDEALKAFGSDEMYVEKDVQHPKHIEVQVIADEHGHV
                     MHLFERDCSVQRRHQKVIEFALSVVLTPERRVEVCGLAVKLMKSVHYQNAATIEFLATP
                     DHFYFIEVNPRVQVEHTVTELITGIDIVKTQIRVAAGEDLHQDIGLPQQDDLKFHGAAI
                     QCRVTTEDPENNFMPDTGQVTTYDAPGGTGVRLDGNVYPGYKVTPYFDSLLVKCCTRGE
                     DFSDARIKMLRALEEFKIRGVKTNIPFMINVLKHPTFIAGKCSTTFIDENPDLFSFAHR
                     PDTPNQLLQYIGNVTVNGFAGVTKRTKLVLPNMQEPQAGQLTPNQHTTKTVKDILDKQG
                     ADAAMQYVKDQPRVLLTDTTMRDAHQSLFATRMRTHDMLPAMNVYDRAMPNLFSVESWG
                     GATFDVCYRFLGEDPWTRLRLLKKYMPHTLQQMLLRASNAVGYQNYPDNELKRFIEHSA
                     ATGVDVFRIFDSLNWIDQMERSITYVRETGKIAEGTMCFTGDFLSPHEHKYTLDYYMKL
                     AQLLVDAGAQIIGIKDMAGLLKPKAAYELVGSLKAKFDVPVHLHTHDTTGNGVPTYVAA
                     TNAGVDVVDVAMSSMAGTTSQPSLATFYYALEGDKRQPDLNMHNVAVLNRYWSNVRPLY
                     NDFSNGVNAPQPDLYQTEMPGGQYSNLKQQAQSLGINDFSLVEEKYREVNQLLGDIIKV
                     TPSSKVVGDMAIFMIQNHLDKDNILTKGQRVDFPESVVNFFAGDLGQPYRGFPKDLQKV
                     VLKDHPAITVRPGSLAKPVDFAAVKQELAAKINQEPSEDDLQGYIMYPKVFTTYFRNHQ
                     RYGEVMDLDTTTYYQGMRPGEILHVKYGQGKEMIIKLDFVSAPDDDGDRFLFFELDGRI
                     LKIKVKDNSMKDKVVSVSKADPDKSNEIGMPLNGNVVKVNVAEGDQVKVGDVLVVTEAM
                     KMESAVKAPFTGKVTKVYAKVGDALKSQDLLLTLTEDA"
     CDS             complement(10894..11910)
                     /locus_tag="ctg24_10"
                     /transl_table=11
                     /translation="MTNIKRTISKAYQQLSNFDRVRIETLLNQGFSQARIARELNRSRS
                     TISREITRGSVLQRIPGHKVALIYFADTAAYLHAQRRERCRPKTMLEKNPEFYAACAAA
                     IKQRPRVHSVDSFVHTFKREHADEVVPSTPTVYRDIEAGRFELRTHDLPRKPSLRIKRS
                     HSHTRTNKTKLGTSIDERPIEVQDRRQGGHWEGDLVKGKRVDSEPALLVLTERTSRFEI
                     IIKLANYKASTCKVGLQSIIDDYGAEYFTTITFDNGSEFAQLDSVEGTDVYFAHPYSPW
                     ERGTNENQNGLLREFIPKGRSLHHYDIIDIQSFQDALNSRPRRILGYRSAAELMPEL"
     CDS             12696..13640
                     /locus_tag="ctg24_11"
                     /transl_table=11
                     /translation="MTRKVAVVGMGHVGATVAHYLVAGGFTDDLALYDTNEAKVRADAL
                     DLRDAMANLPFHTNLTVNDDSQLADCDVVISTLGKSKLVDTPDHDRFAEFKFTRTQVPL
                     VAKKLVDNGFHGKLVDVTNPCDVITSMYQKLTGLPKNHVMGTGTLLDSARMRACVGEAL
                     HVDSRSVVGFNLGEHGNSQFTAWSTVRVLGKRVLDLVDERHLDLTDMEERARQGGYMVY
                     KGKKYTNYGVATAAVRLTNALLSDARTEMPVSNYREEYGTYLSYPAVVGRDGVVEQLHL
                     DLTAAEKEKLATSAKYIKDRLSAEEQRAAQQDA"
     CDS             14007..14306
                     /locus_tag="ctg24_12"
                     /transl_table=11
                     /translation="MVIDTHTEIYDLLREYERTCVTITFKDGTSKKIFFLDVDDEYQEN
                     DVRPEKDCIVYNITDSISYGNGIPLDKLRSSPKCWCKLNSASLSFHKLKHTGFF"
     CDS             complement(14271..14342)
                     /locus_tag="ctg24_13"
                     /transl_table=11
                     /translation="MTVYHGIEKDDNSEEAGMLKLVK"
ORIGIN
        1 tgccatgctc accacgttcg tgaccataac gctgcgcaga atattctaac taaaggaatt
       61 attaaattag cctaattcgg cttgtcccta tggcaacctg gggacgctaa aggcattggt
      121 aattgccgtg taagacgaaa cggttcgtag aactattcgc agtggtgtat ctatgcaaat
      181 tgtgattcaa acactcatca gaagggtgct tgctcacaag ctactgactt tagtcagtgg
      241 tggttgactt tgcgtatgtt agatagaaaa cgtggtcaat aaccacaggc ctagtgtcta
      301 agccggccga agaacgatgc gttccgcccc tagcttagtc atacgacctg ccaagcaagt
      361 tatttgccac tcccttttaa ttagtcgata tcgttgcaaa ttacgaccgg cttgattaag
      421 tccgccgact tgtggtgcat cagttcgatg gcgtccggaa tcttctcgaa gtcttcgaag
      481 cgatgggtga tcattagtga tggatcgatc cggccgttca ccacgaggac ggccagcttt
      541 tccatccgca ggcggccacc aggcatcagg ccaccgtgga tggtcttgtg acccatccca
      601 acaccccagt caccggcgtt gaagaccacg tcgtcgtgac cgtttaagta gttaacgttc
      661 ccgattgagc cacccggctt gagcatccgg acggcttctt caaaggtgtc cttggcgttc
      721 ccaccggcga tcaggacctt gtcgacccct tggccaccag tggcttccag gatttggtcg
      781 gaaatccggc cgttgtggta gtcaatgatg tcggttgcgc cgtacttttt agccacttcg
      841 accgtctttt cccgtgaacc aaccgcaaag acgcggccag ccccgtggag caccgccccg
      901 cgcagggcca tcaagccaac cgggccgatc ccaatcacgg cgacggcatc cccaaaggtc
      961 acacccgcca tttcggaagc gtggaggcca gttgggatca tgtcggaaag catgcaggcc
     1021 tcggtcgggt caatttcatc cggtaggtga gccaggttcc cgtcggcgtc gttaacgtgg
     1081 aaacgagtgg cgaagacccc gtccttgata ttagagaact tccagccgcc cagcatcccg
     1141 tcggaatcag tggcgtagcc agcttgggag taaacgtcag accagtttgg cgtgatcgcc
     1201 ggaacgagta cccggtcacc cggtttaaag tccttgacgt cttcaccgac ttccacaacc
     1261 accccgcagg cttcgtggcc gagaattata ttctcccgtg gccctaaggc atcttcaaac
     1321 acggtgtgga tgtcagaagt acacgggggc aacggctagg ggacgtacca gggcgtcacg
     1381 gctgcccacc ttgggatctt ctttttcaat aaagcccgtc ttgttggggc ccagcattgc
     1441 aaaacctttc attcataact accacctttc ttgattagtt gccgtcattc taacataaat
     1501 catgttataa ccaagtcttc atatgtgagt ttaattaatt ttaaagaaag cgttctcatt
     1561 ccctgaaagg gttaaaataa cagggattat gatagttaag aaattgattg gaaataaata
     1621 aaatgactgt gataatcccg tacgaggtca ccacagtcat taatcattct ataattagcg
     1681 gattatttag cttttaaatt cccaacgaag agggacgcca ccccggccac caaggcggag
     1741 atgaccaggc cgaagaaggc cgtgtcgtat gaaccgctca gctgaacgat ccagccgatt
     1801 aagaggggac cgaagaagcc cccgagttgg ccaccaaagt taatcgtccc gatctgggag
     1861 ccataagtct tttgcgggaa gagttgggcc gcgtaggaga agatcccggt gaaggctagc
     1921 gacttgacga agtaggtggc catttggaag atcactaacc aaaccaggct ggtggacttg
     1981 tagagtccaa acatggtcag gaccgttaaa aaggaggcca ggataatcat caggcgttcg
     2041 tgatttttaa agatgtgcac cattacgtaa ccggaaatca aggccgcaat ccccccggca
     2101 atcgtcggta ggggaactaa ccaagccaag ttggctaagt tgatgtggcg ggcgtttaag
     2161 aagtaaaccg gcatccaggt ttccatcccc ttggtgataa tgtttaaggc cagcccgatc
     2221 accacgaagg cccagacccg cgggtcgatt tccttccagt ttatcttttg ccgttcttgt
     2281 ttcgttaccg tttgtccacc gccgtgaccg cggaagaaga ggtagctgac catcaagagt
     2341 aggccaaagc cccccaacca gaagaaggcc gagcgccaac cggtagcggc gatgattggc
     2401 acgatgatga aaggggccag ggccgcgccg gcgtagttag aggaaattaa ggcggcggtc
     2461 agttgggcac gcttgttgac cgggaagtcc tgggcgactt gcttcatggc ggccggtggg
     2521 taagggccct cggcgatccc aaacaggaac cgaattacca agagggcggc taaggaccag
     2581 gccagcccgg taaagatcgt catcaccgac caaaaggcga gggtggcgat gatcacctta
     2641 cgggaagaga agcggtcggt cagccagccc cccgggattt gcatgatcgt gtagcccaag
     2701 aagaagacgg aactagtcgc ccccagtgcg gccgggctaa cggagaaatc cttgccgatc
     2761 gcggccaacg ataagttaag cacggtccgg tcggcgaata agagcatgta accaaggtat
     2821 aaaatcacaa aggaaccgag cgacagcgcc cggcggttgg gttttgcatc catcatttat
     2881 ttgtatcttt cttttctcaa ttgattattc tgttgtggca tgactaagcg ttagcgacca
     2941 ggtcttgtaa gcgaaacttt tggaccttgc cgctggcgtt tttcggtagg gcgtctgttt
     3001 gcaagtagac cttgggtacc ttatagtggg ccaggtgttc acgcccgaag gcctccaact
     3061 gctgaaagtc gacgggttgt ttgctgacga ctacggccac gggaacggcg ccccactgtt
     3121 gatcattacg gccgaccacg gcaatttctt ggatgcctgg gtactggcgc aagacgtttt
     3181 ccacctcggc ggggaaaatg ttttcgcccc cggagatgat catttcatct aaccgtccgt
     3241 cgacgtacaa gaaaccgtct tcatcaaagt ggccgacgtc gccggttcgg taccagtcgc
     3301 catcgtgctt agccgcaaac ttggccggtt ggtttaagta acccggggtt aaggccgggg
     3361 tctggatctc gatttcgtga tgctcaccca ccaaacgcag ctgggtggta aacaggggct
     3421 taccgaccga accaaggtgg taaggcgcct cttcagccga gagggcaacg aactgcgagc
     3481 aagtttcggt catcccgtaa cactggacaa ccggcagccc actttcttcg caggcgttaa
     3541 gggtcgcccg gtcaatcgtc ccaccgccga gtagcaccag gcgaaaggcc gatgagtaac
     3601 agtggtcatt tgcttggacg tcttcgagca tcttctttag catgtaggga acggccgaaa
     3661 tgatcgtaac cggttcgtcc tccaggattt ggttgaccac ttgcgcatcg aaatggttga
     3721 ctaggcgaac gcccatcccg taaatcaggc cccgcattag aattgaaaag cccgaaatgt
     3781 ggaagatggg ggcgacgcac aaccagaggt cgtttggcaa caccccgagg ttcaaagatg
     3841 acgaaatggc ggaggccaag tggttgccgt aggtttgcaa gacgcccttt ggctgaccgg
     3901 tggttcccga ggtgtacatg atcgaggcca cggcgtctag gtcaaccgtc ttcgtcaaca
     3961 ctgccgccgg ggcagtgccg gctgtcaatt ccgaacagag gacccggtgc ccaccgtaat
     4021 agcgatcggc tagttggtca tcgactaaga ctaggtcgag ccccgcgtcg ccgatttggc
     4081 gactcagttc ttcaggggcg aggcgccaat ttagccaaac gatggtcttg tcggcggcta
     4141 agacccctag ggcggctaag taaccagcca ggttattgtg ggtcatcacc ccaacccggg
     4201 gctggtccgt ctgcgcttga atctggccag cacggtgggc gaccagggga accagctggg
     4261 caaaggtgta ggcggtggta ccgtcgttaa ccgccacccg gttagggttt agcgaagcct
     4321 gcttgaggag ccaatttgta atctccatga cggcctccta cgggaacttc gggaacttat
     4381 cgaagtcggg gtcgcgcttt tggttaaagg cgtcgcgccc ttcctttcct tcgtcagtcg
     4441 tgtagtaaag catcgtggcg tcaccggcaa attgttgaag ccccgctaaa ccatctgtat
     4501 cggcgttcat ggccgcctta atgaagcgaa gggcggtcgg tgacttcttt aagatttcat
     4561 gacaccagtc taaagtaact gattcgacct cagctagggg cgccaccttg ttaatccagt
     4621 tcatttggta agcttcgtca gccgtgtaga agtggtttaa gaaccaaact tccttggccc
     4681 gcttgtggcc gatcacccgg gctaggtaac ccgagccata accggcgtca aaggaaccca
     4741 ccttcggccc cgtttgccca aacatggcgt tgtcggcggc gatcgtcagg tcacaaacca
     4801 gttgtaagac gttcccgccc ccgactgacc agcccttgac catggcaatc accggcttgg
     4861 ggatgatccg aatcaagtgt tggaggtcca aaacgttgag ccgggcgatg tggtcggggc
     4921 ccacgtaacc cccgttaccc cgcacggatt ggtcaccacc ggaagaaaag gccttatcgc
     4981 cggctccggt aagaataatc actccaattg tgctatcatc acgacagatg ttaaacgcgt
     5041 cgatcatttc ggcgaccgtt accggggtga aggcattgtg cttttccggc cggttcatcg
     5101 taatcttggc gatcttatcg tcgcgttcaa aaataatttc ggaatactcc ttaacggggg
     5161 tccagttagc actcgtcata acaaactcct ttacaaaatc cagaggtaca aaaatgaatt
     5221 tacttgaaaa cttaggcatt caccaggact tggtgaccaa agaccgcgtt gaactctcca
     5281 tgccggtcca agcaaagcac ttgcaaccgt acgggatcgt tcacggcgga attaacaccg
     5341 tactggcgga aaccgcagcc tccctagggg ctaacgccaa cgtagcgccg gggcgaatcg
     5401 cggtcggggt caatgttacc acacaacata tccgtgcgat acgggaaggg gagatttttg
     5461 tggttgcaac ccctgatcac gttggtcaca cacttcagac ctggcaagcc cggctgctgg
     5521 ttaacgaccg attaacggct accgcaacca tcaccctgat gaacgtccca gcaccaacca
     5581 acaatcataa acattaattc acaaattggc tactattatg cttagaaagt tgccgggtga
     5641 ccattggggg attacctaaa tcacattttt ttaattttat attatgtaaa tcaatcgaga
     5701 agtcgtcggc taactgttat gaaaggggcg ccactacgca gtcgatttaa gttggccccg
     5761 attttgtatt agtgttgcaa ccagtacgca aaagcacaca taatttatcg aggggaggac
     5821 ccgatatgag gaaatggtgg gtggaattga aactggtcgt cttttgcatc gccgctcttt
     5881 tcaggtaatt actctaacgg cgctaattag acttacttct gtaaattcac attatgtaaa
     5941 gatatcgttt gatgattaaa gaagcctcaa aggccctccg aggatgacaa tacagatgtt
     6001 caagacttaa ttacgtacgc tctcactgag ttcctgaaca atatggtatt taacgacatt
     6061 cgcaattcga caggcaaaat taactccttg aatctcggca accttggtaa ctcgcttggg
     6121 gcattggggc gatggtggac agagatactg ttgtttcttg atttttaaga cagctggttt
     6181 tccagccggt gtaaggattt tgatcgttac gggccgctta cggaagccat tacgacgcat
     6241 caactggccg taaagcggac agtgcatggg ataagactga attaaatgga taatctttag
     6301 ttctttatct tcagttaaaa atggtttgtc aggttttaag taaggatcct tgattccagt
     6361 ccaaaaattg atatcattag tcatgaggaa tatatccttt ctaagacaac tgagtggtta
     6421 tggggataac ttaagacagt tgtctttttt tatttttaaa tcaatggtac agcaagtaac
     6481 aaaaaacggt aaagacaaga aatcatctta tccttaccga atatcataga accttcaagg
     6541 ataactgcgg tcaaaacacg tccgcgtttg tccaagaagg actgcttttt taattactaa
     6601 accagttctc gaaccgtccc cgtcatgaat gcgcggggcc cgttatctgt ctgcacacat
     6661 aaccagccat catccgtaat atggtcaaag tatcccctaa cacgtcccgc tcctgtatca
     6721 acgaggagca gcttgttaat aaggtattga tgagtctggt aaacctgcag gatgtgtttc
     6781 caggacgcgt ttgctaacag gtcaaggaag tgcgcagcga ctgcatcaac gatttgtagc
     6841 cgttgatggt catcaattga ggtggtgccg agccatcccg cacgtaactg aagtgctggc
     6901 ggcaagggaa cagttggtgc cgccaggtta atcccccagc cgaccactat tccccgcggc
     6961 tgattattcg cggtcatttc catttcagca agaatcccca ccaccttctt tcgctcacag
     7021 tacaggtcgt tcacccattt aatagtaatg ggaacagtga attgcttgct gaggacttca
     7081 taagcagcga ccgcggcagt caccgttacc tgaccagcac tttttgccag gtagctaaag
     7141 ggtaaggcaa gggtgaagta ggccccactt cccgcgggtg aataaaactt ccggctggtc
     7201 tttccgtggc ctgccgtttg ctgccgggcg gagatgagaa agggctgatc tttcaccttt
     7261 aaccgttcct ttgccatttc gttagtcgaa gtgactactg gctgatcggt tgtctggata
     7321 tgatgtgctg tcagtctagg aaattcgtac atcattgcta ctctccttat caagcatcct
     7381 cagtcaatgt tagtaagagg tcctgactct ttaacgcatc gccaacctta gcgtatactt
     7441 tcgtcacctt accagtaaat ggcgctttaa ctgctgattc catcttcatc gcctcagtaa
     7501 caaccagaac gtcaccaacc ttgacctggt caccttctgc tacgttaacc ttgaccacgt
     7561 tcccgttcaa cggcatcccg atctcattac tcttatcggg atcagccttt gaaacactga
     7621 caaccttgtc cttcatgcta ttgtccttaa cttttatttt aaggatccgc ccgtccagtt
     7681 caaagaagag gaagcgatca ccgtcatcat ctggtgctga aacaaagtcg agttttataa
     7741 tcatttcttt tccctgacca tacttaacat gcaaaatttc accaggacgc atgccttgat
     7801 agtaggtcgt ggtatcaagg tccatcactt caccgtatcg ctgatggttg cggaagtaag
     7861 tggtaaagac tttcggatac atgatgtaac cctgcaggtc gtcctcgctc ggttcctggt
     7921 tgatctttgc ggccagttcc tgcttaacgg cggcaaaatc aaccggttta gcaaggctcc
     7981 cgggccgaac cgtgattgca ggatggtcct tcaagacaac cttctgtagg tccttgggga
     8041 agcccctata tggttgacca aggtcgccag caaagaagtt aaccactgat tctggaaagt
     8101 cgactcgttg cccctttgtc aggatattgt ctttatcaag gtggttttgg atcatgaaga
     8161 ttgccatgtc gccaaccacc ttcgagcttg gcgtcacctt gatgatgtca ccgagcaact
     8221 gattgacctc ccggtatttt tcttccacca ggctaaaatc attgattcct agtgactggg
     8281 cctgttgctt caggttcgag tactggccac ctggcatttc cgtctggtat aggtctggtt
     8341 gcggtgcgtt gaccccgttg ctgaagtcgt tgtaaagcgg ccggacattg gaccagtacc
     8401 ggtttaagac cgccacgtta tgcatattaa ggtccggttg gcgtttatct ccttctagcg
     8461 cgtagtaaaa ggtggctaaa ctaggctgac tggttgtccc cgccattgaa gacatcgcca
     8521 cgtccaccac gtcaacaccc gcatttgtgg cggcaacgta ggttggaact ccattacccg
     8581 ttgtgtcatg agtgtggagg tgaacaggaa catcaaactt agccttcaaa ctaccgacta
     8641 gttcgtaagc ggcctttggt ttcaagaggc cggccatatc cttaatacca ataatctgcg
     8701 ctcccgcgtc gactaataac tgtgccaact tcatgtaata atctagggtg tacttgtgct
     8761 cgtgaggact aaggaagtcg ccggtaaagc acattgttcc ttcggcgatt ttgccggttt
     8821 cccgaacata tgtaatgcta cgttccatct ggtcaatcca gttgagggag tcaaagatcc
     8881 ggaaaacatc caccccggtt gcggcactgt gctcaatgaa ccgcttcagt tcattatccg
     8941 gataattctg gtaaccgacc gcgttcgacg cccgcaacaa catctgctgg agagtatgtg
     9001 gcatgtactt cttcaataat cgtaatcggg tccacgggtc ttcaccaagg aaccggtagc
     9061 acacgtcaaa agttgccccg ccccagcttt caacagaaaa gaggttaggc atcgcccggt
     9121 cgtaaacatt cattgcgggc aacatatcgt gcgtccgcat ccgagtggca aaaaggcttt
     9181 ggtgagcatc acgcattgtg gtatcagtca gtagtaccct cggctggtcc ttaacatact
     9241 gcatcgccgc atcggctccc tgtttatcca ggatgtcctt tactgttttt gttgtatgct
     9301 ggttaggtgt aagttggcct gcttgtggtt cttgcatgtt aggcaaaaca agtttggtcc
     9361 gcttggttac ccctgcaaag ccattgacgg taacattgcc aatatattgg agcaactggt
     9421 taggcgtatc gggccggtgc gcaaagctaa agaggtcggg attctcgtcg ataaacgttg
     9481 tcgagcattt tccggcaata aacgtgggat gctttaacac gttgatcatg aagggaatat
     9541 tagttttgac tccccgaatc ttgaattctt caagcgcccg cagcatctta atccgggcat
     9601 cactgaagtc ttcaccccgg gtacaacact taacgagcaa ggaatcaaag taaggagtga
     9661 ccttatagcc gggatagacg ttcccgtcaa gccggacacc ggttccccct ggcgcatcat
     9721 aggtcgtaac ctgtcccgta tctggcataa agttattctc gggatcttct gttgtgaccc
     9781 ggcactgaat ggctgccccg tggaacttga gatcgtcttg ctggggaagg ccaatatctt
     9841 gatgaagatc ttcaccggcc gcaacccgaa tctgggtctt aacaatatca atcccagtaa
     9901 tcaactcggt aacggtgtgt tcaacctgca cccggggatt aacctcaatg aagtaaaaat
     9961 gatccggggt cgccaagaat tcgatcgtcg ccgcattctg gtagtgaaca ctcttcatca
    10021 gcttgacggc caggccacaa acttcgaccc gccgctcagg ggtcaagaca acgctaagtg
    10081 caaattcaat aaccttctgg tggcggcgct ggacagagca gtcacgttca aagaggtgca
    10141 tcacatgccc gtgctcatca gcaattacct gcacttcaat atgcttcggg tgttggacgt
    10201 ccttttcgac atacatctca tccgatccaa acgccttcag cgcctcatcc ttcgcctgat
    10261 caaactcgtc ggtgagttgc tggtcgtcat tgatgatccg catcccccga ccgccaccac
    10321 cattagcagc cttaaccatg atcgggtaac catattggtg ggcaaaatcc tttacctggt
    10381 caacattttt aacatccccc gataaaccgg gaattggttg cagccctgcc tcaacggcca
    10441 cacgtttagc aaccaactta tccccaaaca tacgaaggtg ttccggctta ggtccaataa
    10501 actttaatcc attatcaata caggcctgcg caaggtcagc gttttctgcc aggaagccat
    10561 aaccagggtg aacagcttct gccccgcttt ctttggccac ccgaattact tcatcaatat
    10621 ccaggtaagc atcaagcgga tgttcaccag ccccgatttg gtacgcctca tcagcagcaa
    10681 agcggtgcgc actatactca tcctccttag cataaactgc gacggctttg attcccagct
    10741 catgacaggc gcgaataatc cgtgtagcaa tttcaccacg gttagcaact aaaacttttt
    10801 taaacacaat tatccaccat cctttttatt aatccccgta ttgtcaatct aagtgcaaca
    10861 gtttctagtc caatcctata agtggtacac cgcttagagt tccggcatta gttccgccgc
    10921 actccggtag cccaagatac gacgaggccg gctgttaagt gcgtcctgga agctctgaat
    10981 atcaatgatg tcgtaatggt ggagtgagcg acctttcgga ataaactctc gtagaaggcc
    11041 gttctggttc tcatttgttc cgcgctccca tggtgagtac ggatgagcaa agtagacatc
    11101 agttccttct actgaatcta gttgtgcgaa ctcactgccg ttatcaaagg tgatggtggt
    11161 gaagtattcc gcaccgtaat catcaatgat ggactgaagt cccaccttac aagtacttgc
    11221 tttgtagtta gcaagcttga tgatgatttc gaagcgactc gtccgctctg tcaaaaccag
    11281 caacgcaggt tcgctatcaa cgcgcttacc tttcactaaa tctccttccc aatggccccc
    11341 ttgtcgacgg tcttgaactt caatgggtct ttcatcaatc gaggtaccaa gcttcgtctt
    11401 attggtgcgg gtatgggaat ggcttcgttt aattcgcaag ctgggtttgc gcggtaagtc
    11461 gtgggtccgt agttcgaatc taccggcctc aatatcccgg taaaccgttg gtgttgaagg
    11521 aacaacctcg tctgcgtgtt cccgtttgaa ggtgtgcacg aagctgtcca cactgtgtac
    11581 gcgtggacgt tgcttgatgg cagcggcaca ggcggcgtag aactcggggt tcttctcaag
    11641 catcgtcttg gggcgacacc gctcccgccg ctgagcgtgc agataagctg ccgtatcagc
    11701 aaagtaaatc aacgctacct tatgcccggg aattcgctgt agaacggagc cacgagtgat
    11761 ctcacgcgag atagtactac gagagcggtt gagttcgcgg gcaatccgtg cttgggagaa
    11821 tccctgattg agcagagttt caatgcgaac gcgatcaaaa tttgatagtt gttggtaagc
    11881 cttagagatg gtacgcttga tgttggtcat gatgtgcctt tcttatgtgc ttggttgctt
    11941 ataagcatag gtcatcatgg cctttttggt ctatttaatt atgtgttgca cttagattgt
    12001 aaacgcgggc tttttattaa tccttcacgc ccatcacgtc attactattg gcggtgaggg
    12061 tggctgtatt tgtagaaata ttaatattac caaccattgc actcacctcc tcatttttct
    12121 aatcaaattt taaaacaaac tataatcaat ctaagctaac gtgtcaataa tttttcctca
    12181 agaaatgccc gctatcaaac gaatttatac tataaattat ctgcctttgc acccatcttt
    12241 tctcatcttt ttttaatttt tatcttgact tccctatctg cctagtgata tagtacttaa
    12301 caatcaattg aaacaagtta aagacgttga gcgagaaaca gcgatgaggc cgaagcaaga
    12361 gagctggtgg gtggtgtgaa ccagtgagag gccgcaccta ctaatcactc gtgagtcgta
    12421 cgccgaacgg attccctagt agagcgtatt ggtagcaccc attaccgtgc cggctaatac
    12481 cacattattt gtggcggttg gttgaggcga cattatgtcg taaagaaagg tggtaccacg
    12541 cacaagcgtc ctttttagtt cttagattta tcaagagcta gaaaggacgc tttttgtttt
    12601 gatattaaag gtggtggtga tcatggcaga cagtgatatt tctgacatta gtaagattaa
    12661 aggcaacaat acgataatcg aaaggaagtt ttattatgac aaggaaagta gcagtagttg
    12721 gaatggggca cgttggcgca actgtcgccc attatctcgt tgctggtgga ttcactgatg
    12781 atttagccct ctatgatact aacgaagcaa aggtccgtgc cgatgcgctt gacctccgtg
    12841 acgccatggc gaatctcccg ttccacacaa acttaaccgt taatgatgat tcacaattag
    12901 ctgactgtga cgttgtaatc tctactctgg gaaagtctaa gctggtggac acacccgatc
    12961 acgaccgctt tgcagaattt aaatttaccc ggactcaggt tccattggtc gctaagaaac
    13021 tcgtcgataa cggttttcat ggcaaacttg tcgacgttac caatccctgt gacgtcatca
    13081 cttcaatgta tcagaagctc acggggctac caaagaatca cgtgatgggt acggggaccc
    13141 tgctagactc cgcacgaatg cgcgcatgtg ttggggaagc cctccatgtt gactcacgat
    13201 ccgtggtcgg cttcaatctt ggtgaacacg gtaactccca atttactgcc tggtcaacag
    13261 tccgggttct cggcaaacga gtactagatc tggtggatga acggcacctc gaccttaccg
    13321 acatggaaga acgcgcacgg caaggaggct acatggtcta taagggaaag aagtatacca
    13381 actacggtgt tgctactgcc gcagtccggc ttaccaatgc cctactaagt gatgcccgga
    13441 ctgaaatgcc agtttcaaat taccgtgaag aatacggaac gtacctctcc taccccgcag
    13501 tcgttggtcg tgacggggtg gtggaacaac ttcacctgga ccttaccgct gctgaaaaag
    13561 aaaagctcgc tacctctgcc aaatacatca aggatcgcct ttctgcagaa gaacaacggg
    13621 cagctcaaca agacgcctaa cttgctggta ttaaatgatc tctcctcaaa catatcccta
    13681 ataaagcacc aaccttattc tgtataactg aaacttgaaa gctgataacc atgtcaaaca
    13741 ggcgaggtta tcagctttca agtttcagtt aattaatcaa cggcggagcc agcttaaata
    13801 gctggctttt attatgcaga aaggaggtaa aaatagctaa agttcaaaac gaaatggcga
    13861 cccggatcac tgttgatact gtccaggcgg ctaattccat gcaggcaatg cgtcaggcta
    13921 tctcagccaa tacgaatgca tggaaggcaa ttaaaaatca accattctgt gacagaatat
    13981 taagtagtac tggggagtga ataaagatgg tgatcgacac acatactgaa atatatgacc
    14041 tcctaaggga atatgaacgg acttgtgtga ccattacgtt taaagacgga acgtccaaga
    14101 agattttctt tctggatgtt gacgatgaat accaagaaaa tgatgtgaga cctgaaaaag
    14161 attgtatcgt atacaatata acggattcga tatcatatgg taatggcatc ccgctagata
    14221 aacttaggtc aagtccaaaa tgttggtgta aattaaattc cgcgagttta tcatttcaca
    14281 agcttaagca taccggcttc ttctgaattg tcatcttttt caatcccgtg gtaaacggtc
    14341 atg
//
