LOCUS       gnlProkkaHLENPMOL_384  13738 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HLENPMOL_384.
ACCESSION   gnlProkkaHLENPMOL_384
VERSION     gnlProkkaHLENPMOL_384
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 11:40:57
            Original ID  :: gnl|Prokka|HLENPMOL_384
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13738
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13738
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3387:3738]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3388..3738
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13738
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13738
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             232..1743
                     /locus_tag="ctg375_1"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             1784..2884
                     /locus_tag="ctg375_2"
                     /transl_table=11
                     /translation="MFSKPVKKEPNMKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGV
                     VYSLPKTQIELEIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVP
                     NSETTYFVKLKDKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREF
                     LTEEILMASSTAKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEE
                     AMTQMFSGTCNKEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDL
                     KSVKIPQEDGKKKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLF
                     NKNSTIKVYFDPNTGGLLKVDREEGK"
     CDS             2921..3205
                     /locus_tag="ctg375_3"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(3388..3738)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg375_4"
                     /sec_met_domain="PqqD_RRE (E-value: 1.8e-11, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6.6e-18, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(3836..5224)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg375_5"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(5472..5867)
                     /locus_tag="ctg375_6"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVVKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             complement(5874..6647)
                     /locus_tag="ctg375_7"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             6683..7147
                     /locus_tag="ctg375_8"
                     /transl_table=11
                     /translation="MVGDLFRHFSNQSVLYGSQQLGRVVGTERRKLLFKVFGMIGVVDK
                     THIDGDSQLRLRRITVGRYCLVVLIVPCDFSVNLQVGILTRLEQLQTGLPDEDIFQVLI
                     EFGCQRSIYILRLDREVGYRNGLYLIIIDRRSVKLIGNSARNDYQRQAEQ"
     CDS             complement(7167..8408)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 385.8; E-value:
                     4.8e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg375_9"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPAVCKDDDDIQDTEEYVEEPPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(8418..9512)
                     /locus_tag="ctg375_10"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(9517..9870)
                     /locus_tag="ctg375_11"
                     /transl_table=11
                     /translation="MKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGD
                     FMGGPYVSHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQNQIP
                     LGEASKEAEQTNK"
     CDS             10081..10332
                     /locus_tag="ctg375_12"
                     /transl_table=11
                     /translation="MLPFQERNLTVHFRTGKEVDNRLFVLFHKLLEFFFVRSLDSQYHL
                     RIGIHVLRIFERGFRIYILYIYNNNVTYQLQRRIIIFR"
     CDS             complement(10576..11610)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg375_13"
                     /sec_met_domain="PF04055 (E-value: 3.4e-18, bitscore: 57.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLDMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
ORIGIN
        1 agaaatcttt ttcagggaga aataaaagta agttcataat ggtgcagcat tgaattattt
       61 tttggcggag ttattccaac acttaatagt tcaaaagcag atatttcttt gaccaaaaga
      121 tagaactaat gatgaattaa aagttgcaat tatggttttc ttcccacaac aaacgggaaa
      181 agtcagaaga atcatgtaca tttgtaatcc gaaaactaaa agaacatcgc aatgaaaata
      241 tttccaagca gcagtatcaa gaaattggac gcttatacca ttgagaacga acctattgca
      301 tcaatcgatc tgatggaacg tgcagcaacc gtattaacaa aagccatcac agacagatgg
      361 aatacggaaa cgccggtcac tatctttgcc ggaccgggga ataatggcgg agacgctctc
      421 gccgtagccc gcatgatggc tgaaaaagga tataaaatcg aggtatttct cttcaacacg
      481 aaaggagaac tttcacccga ctgccagacc aataaagaac tggtagaaat gatggaagaa
      541 gtaaaattcc acgagatcag tacccaattc gtacctcccg ccctgacgcc cgaccatctg
      601 gtaatcgacg gattattcgg ttcaggcctg aacaaaccgt taagcggcgg attcgctgcc
      661 gtagtgaaat acatcaattc ctcccctgct atggtagtag ccatcgacat tccttccgga
      721 ctgatgggag aagaaaacac attcaacgta aaagctaata ttatccgtgc cgacgtaact
      781 ttcagtctgc aactgccgaa gctcgccttt cttttcgcag agaacacgga atttgtcgga
      841 gaatgggaag tgctggacat ccaattaagc gaagacggta ttgaagagat ggaaacgaac
      901 tacgaaatgt tggaaataga gcaaatccgt tcactcatca agccacgcaa acagtttgcc
      961 cacaagggga acttcggcca tgcactattg attgccggtt caaaaggaat ggcaggagcc
     1021 tctgttcttg ctgcccgcgc ctgcctccgt tcgggagtag gattactgac tgttcatgca
     1081 ccaatgtgca acaacgacat cttgcaaacc tccatacccg aagcaatcgt agaaaccgac
     1141 atcaacgaaa cctgttttgc cgtacctacc gacacggacg actatcaagc agtcggcatc
     1201 ggtccgggac tgggacgaaa cgaggaaacg gaagctgcct tgttggaaca actggaacac
     1261 tgccagactc ctgttgtggt ggatgccgac gcacttaata tcctcgccaa ccaccgtcat
     1321 gcacttaccc acctgccgaa gggttccatc ctcaccccgc atccgaaaga actggaacgt
     1381 ctgaccggca aatgccagga ctcttacgaa cgtctgatga aggcttgcga actggcccgt
     1441 gccgcccatg ttcacattat tttaaaagga gcctactccg ccatcatcac ccccgaaggt
     1501 aaatgtttct tcaacccaac cggaaatccg ggaatggcaa ccggaggtag cggtgacgta
     1561 ctgaccggag taatcctggc actacttgcc caaggttatc ccaccgaaga agccgctaaa
     1621 atcggcactt acattcacgg actggcgggc gatgtcgctc aaaagaagca aggaatgatc
     1681 ggaatgatcg caagcgatat tatcacctgt ctgccgacag catggcgact tgtaagcgaa
     1741 taaaagttaa gaacttacag ttttttcaat aacttcatta actttgtttt caaaaccagt
     1801 taaaaaagaa ccgaatatga aaaagttgat tatagcagca ggactactaa tgacaacgtc
     1861 cgcctatgca caaaccgaag tactgacagg ggttacccga ggaaaagact atggagtggt
     1921 ttacagtctt cccaaaaccc aaatagaact tgaaataaaa gccaacaaag tcaactatac
     1981 tccgggagaa ttcagcaaat atgctgatcg ttacctgcga ctgaccaacg tctccgccga
     2041 ccctgaagag tactgggaac tggctagcgt aaaagtgaaa tccgtaggtg tgcccaacag
     2101 cgaaactacg tatttcgtaa aattgaagga taagacagta gcaccgctta tggaactgac
     2161 agaggatggc attgtgaaaa cgatcaatgt tccttacagc aatagcagtg taggcaaaaa
     2221 agctgctccc gcccccgcag tcctccaaaa gaaagcgaat cctcgcgaat tcctgaccga
     2281 agagattctg atggctagct ccaccgccaa gatggccgaa ctggtggcta aagaaatcta
     2341 taacatccgc gaaagcaaaa atgccttatt gcgcggacag gctgacaata tgccttcaga
     2401 cggagcacag cttaagatta tgctcgacaa tctgaatgca caggaagaag ccatgacgca
     2461 aatgttctcc ggcacctgca acaaggaaga gagaacattc actgtccgcc ttacccctga
     2521 caaggaattt aacaatgaag ttgctttccg cttctcgaag aagttaggtg tagttgccaa
     2581 caatgatttg gcaggaactc cgttttatat cagtctgaaa gacctgaaat cggtcaagat
     2641 accacaggaa gatggtaaga agaagaaaga tttggatgga atcgcctaca acgtacccgg
     2701 acaagctatg gttacattga ccgacggcaa aaagaaactt tacgaaggtg aacttcctat
     2761 tactcaattt ggtgtgatag aatatctggc tccggttttg ttcaacaaga attctaccat
     2821 caaagtttat tttgatccga atacgggagg attgctcaaa gtggacagag aagaagggaa
     2881 atagaaaaac gagaaagtga acttctaaaa aacaaagaat atggttggtg aaggacatgc
     2941 attcgacatg atacgccgaa taaaagaggg acgggaagct tcccgcctac gtcgtgaacg
     3001 tgctaacgac aagttgaagc atttaaaccg tgcaaacgaa ccttatccac tacccaatac
     3061 cactcccgaa gaaatggaac gtatcatcca cgactcggag aaaaagaaag agaaagacag
     3121 caattatttt gtttggggaa cgcttattat catgggagtc ctgatagcaa ttgccgtcat
     3181 actttgggct gtatttatca aataaataat aataaattca ccacagagga cacggaggac
     3241 acagaggttt aatctttttt attcactata gagtaacaca gagtctcacg tattgagaat
     3301 cgtatttatc gctctgtttt acttgcggaa agagagagaa gaactctgtg tcctccgtgt
     3361 cctctgtggt gaaatataaa ttcctattta tgcgactggt atcaccagtt ttataaatcc
     3421 atctttctgc atttgagaaa gataagccga tacacgcgac tcgtagccct cttcattttg
     3481 aaaatggtct gcgagttttt ctataatctc acgaacattg cgttttccat ctatcagttc
     3541 ccatacagcc gtaccgtgtt cttccaattt cacatgaagt tctttcgaca ttcctttcgg
     3601 cacaaggaag cgttgcatcc acggatattt aaaacgggga aaggagagca caattgtctc
     3661 cccttccctt tctgctgtaa tatgttcact gcgacaggga atgacctcta acaggttgat
     3721 tttctctttg gcagccatac ttcttatttt ttatttcaga gtattcatac tgataccctt
     3781 ttgtttacac cttgatacaa aattcctttg ttactttagg tattgaattt cccagttact
     3841 tttggatatt cgcctcttcc agaccgtatc ccttcttctt gttctctgcc ttcaacatca
     3901 aagccacaat cagagcaagt acaccaaaga gagcaaaaat agtcatcggc aacgtgtagt
     3961 cataagtctg tgcaccgtct actaccggac ctttgcaata agtattcaac acccatccga
     4021 tcaacaaagg aacacccatc aatccccagt tctgtaccca gaaaatcaat gcgtatgcgg
     4081 tacccaactg tttttccgga ataatcttcg gaacagacgg ccacatagct gaaggcacca
     4141 acgagaaggc aaatcccaat ataatcatga tgatagtagc aaaccaccat atattcagta
     4201 taggcagagc aaacatcgta tgcacaaaaa taagcatcac tgatccgatt atcatcaatg
     4261 tggctccctt accgatacgg tcataaagcg aaccgaacaa cggagtcagg ataatcgcac
     4321 caatcggcaa caatccggga atcgttcccg ccaacttcgg atctacgtta tatttctgca
     4381 ccatcaagtc ggcagcatac ttgataaagg ggaatacagc cgagtagaac aatacacata
     4441 gtaatgcaat caaccagaat cctttattgg taataatata cacaatatct ttcatacgga
     4501 acggttcttc cggttccaat ccctctgcat ccaaagaagc atccaacttc ttatcataga
     4561 aagtataaag gaaaaaagca atcgtaccca cgcacaacat aatcagacaa aacaaaatcg
     4621 gagcaggaat atttgtatgg aatgtgccac tctcatccgt agatccgaaa aagtctgcca
     4681 aaggaactgt caataccatc gccagagttg ttccgatacg tgccgtagcc atttcaagtc
     4741 ccatagccaa tgccatttcc ttgcccttga accatttcac tataatcttg gaaacagtga
     4801 taccagcaat ctccacacct acaccaaaga tagcatatcc caatgcagcc aacgtcacct
     4861 gtgttttaaa tccaaagagc atggcacctt ccggaaaagt agtagaaatc gcatagtatt
     4921 tcaatccaca accaaacacc atcaataagc aagctcccat tccggtgaaa cgaactccca
     4981 ttttgtccaa aatgatacca ccgaagatca gcatcaacaa gaatacgtta aaccaaccgt
     5041 aagcgcttgt gaagaatcca taatcaagac tatcccataa tagttctttc tcaagcatgg
     5101 gttttagagg agacattacg tcggtgagga aatagccgca tagcatagta aatgcgacca
     5161 atgctagaac actccatcgg agtacggcgg agtcattcaa tttctgtttc aaatgttctg
     5221 tcattgttat atttaaaaaa gtagttaata atcttataca gccaacaaag gtagttaaat
     5281 ctcgtttgtt tctatcacaa agagattgtt tttacaagaa aaagttaagt gcggattaca
     5341 ctgaccacgc ggaacattga aaatccgtgt aatctgcgta atccgcactt aaatatcaaa
     5401 gaaatgcagc atccgtctgc accttcccat taatggtttt accccaaagt cttacctgac
     5461 gacggagtga attactctgc tgcaggagca ggagtttcag tagccggtgc cggagtttct
     5521 gtagcaggtg cattggtagc aggagcttca gtttgcggcg cagccgtacc tgcgggtaag
     5581 ttatacgggt tagtctgttg ttctttctgt gcctgttcca acactgcatc tttaacaact
     5641 gcagaacgag gaactacata agcagtagca atgctcatta caaccataaa gatggccagg
     5701 ccccatgttg ctttttccag aaagtctgta gtcttgcgta cgcccatgat ggcgttagat
     5761 gaagagaaac cagaagcaag tccgcctcct tttgagttct gaatcagcac gatgaaacac
     5821 atcaacaagg ctgcaataac cattaagata acgaataata agtacatttt tagttatttt
     5881 gaattagcgt taataatcaa tttctccaaa aatctgattt ggtctgcaaa gtaagcattt
     5941 ttttttggat atttcaagct taatttttta attatttcaa gagcttttga atatcgttgc
     6001 tgtttaacat agatttttgc caaagtttcc gtaaaacagc tgtcatcttc ctcttcttcc
     6061 ttcatcgttt cttcttcggt aagttcgtcc gaagaggttg gcgaagatgg catttcttct
     6121 cttaaaggtt tcatgcagag gggagagtcg ctctcgctct tttctataaa gtcgtcaatc
     6181 agttcgaagc ctttgagttt gggcgtttct tcagccggct gttccgtggc cggagtctcc
     6241 tccaaaagga aagaggtgta atccatcgaa tagtcgaaac tggtccgggc agtcacctct
     6301 tcgggtactg tggacaagaa agcgtcgatc aatgctaatg tgcggtctac ggacggttcg
     6361 tctttcagca cctccgtgag aggtactccc tttttccgtg cctgcacatc atagcggtca
     6421 ccttcaatca accggaacaa ctgccgtctg tctgcaatgt aaagaactgc tttccgcagt
     6481 tctccaccga aactaatatc atggagaata tacagattct tcagatacag cagacgaagt
     6541 gactgaaaat acggatacct cgcaagaaga ttgcgcagtt cgtacaaagt atccctattc
     6601 agcgtctcgg gatgctgaat ccattgttga aagttaacag aagtcattta tattaccagt
     6661 ttgctacagt tgcattaaaa atttggtcgg tgatctcttt agacatttca gcaatcaatc
     6721 cgtcctgtac ggcagtcaac aactgggtag agtcgtaggt acggaacgca gaaaactgtt
     6781 gttcaaagtc ttcggcatga ttggtgttgt tgacaaaacg cacattgacg gtgatagtca
     6841 acttcgtctc cgaagaataa ccgtcggcag atactgcctg gttgtactga ttgtaccctg
     6901 tgatttctcc gtcaatctgc aagtcggcat tttgactcgg cttgagcagt tgcagacggg
     6961 tctgccggat gaagatatct ttcaggtcct cattgaattt ggttgccaac ggagcatata
     7021 catactccga cttgatcggg aagtcggcta tcgaaatggt ctttacctta tcataattga
     7081 tagacgatcc gttaaactta taggaaacag tgcacgcaat gactaccaac ggcaagccga
     7141 acagtagcaa agggcgtatt attttcttaa tccaattcat attcttttat ttttctataa
     7201 agtgtacgct cggaaatatt caagtccttg gccgcactct tccgctttcc gtgatgcctt
     7261 tcaagtgctt tgcgtatcat ttctttttcc acttcgtcca gtgacaaagg aggttcttct
     7321 acatattctt ccgtgtcttg tatgtcgtca tcatccttgc aaaccgcagg ctgcatggta
     7381 tgaatgatcg caggtaccga aggctggtgt gtcgtcacta ccggagtagt aaccaccgtt
     7441 cccacttgtc ctacctgccc cacctgtccg gcacgttccg ccatcaggtt gtgcaccatc
     7501 ttcttcagct ccgccacttc ctggcgcata tcgaacagaa cagaataaag aatctcccgt
     7561 tcgctctcaa agcctttact ctcacgcgtt cccatcagcg cgggaagacg ttgcgtattt
     7621 tgtgcaggaa gataattctg caagatagca gcagagatct ccctgttggt ttcaatgata
     7681 gatatttgct cggtgatgtt cttcaactga cgaacgttgc cgggccacgg gtaagccaat
     7741 aactctttct tcgcatcctc cgtcaactgg atagcaggca tccggtattt ctctgcaaag
     7801 tctgcggaaa acttacggaa caacaaaagt acatcgtcac cacgttcacg caaaggcggt
     7861 atttggatag gcaccgtatt caaccggtaa tataaatctt cacggaaacg tccttctgca
     7921 atcgcttgtg tcagattgac attggtagct gccacaatac gaacatccgt cttttgcact
     7981 ttggacgaac ctacttttat aaactcgcca ctctccaaca cacggagcaa acgcgcctgg
     8041 gtaggcatcg gcaactcccc tacttcatca aggaaaatag taccaccgtc ggcttcgcca
     8101 aagtaccctt tccgttcgcc aatcgcaccg gtaaacgcac ccttctcatg cccgaacagt
     8161 tcggaatcaa tcgtgccctc cggaatagca ccacagttga cagcaatata ctgtccatgc
     8221 ttcctccggc tatattgatg aataatctgc ggaaaacttt cttttccgac tccactttct
     8281 ccggtaatca gcacagacaa atcggtagga gctacctgaa tggcaacatc tatggcgcgc
     8341 gacaatgctt cggtatttcc aataataccg aaacgctgtt tcacttgttg tatctctgct
     8401 ctcgtcatca ctcgttttta atcttcgtct actgtatcca gcttcagttt atcactatcg
     8461 tcacgtttct cgtaatactg tttacgcaac ggattggcac gagccacttt ttcccgctga
     8521 cgattacgga acacatcgat ggcaacatag attgcctgac ggaaagaatc ttcacaagcc
     8581 actcccttgc ctgcaatatc gtatgccgtt ccatgagccg gagaagtacg tactaccggc
     8641 aggcctgccg tatagttcac cccgtcttcc atagccaagg ccttgaacgg agccagcccc
     8701 tgatcgtgat acatcgccag gataccgtca aaatgagtat aattgcccga acccataaag
     8761 ccgtcggccg cataaggacc gtagcaaagg attcctttct cttccatttc tttcatggca
     8821 gggataatca cttcctgctc ttccattccc aacaaaccac cgtctccggc atgaggattg
     8881 agagagagca ccgcaatacg cggagcgccg ataccgaaat cctgtttcag acaacgatgg
     8941 aatatcatca gtttctcctg aatcagttct ttggtaatcg tagtcgcgat ctctctgaca
     9001 gggatatgtg tcgtcaccaa agccacccgg aagtcattct tcatcaaaat catcaatgac
     9061 ttatcaccat tacccagacg ttcttcgata tattccgtat gtccggggaa ggagaactct
     9121 tccgactgaa tcgtatgttt gttgatcgga gctgttacga taacgtctat caacccttcg
     9181 cgatattctt cgatggcacg ttccaaagcc cccagcgcag ctttaccggc ttcgggatcg
     9241 ggtttggaaa attccacttt cacctcatca tccgtacagt tcaccacgct caaacggttg
     9301 taccccgctt cggtagcaga gttgacaata ctgaaattgg tctgtatatc cagtgctttg
     9361 cgatgataag ccgctacttt cggtgagcca taaatgatcg gagtacatag ttccaacatc
     9421 gtagggtcgg aaaatgtctt aagaatcacc tcatagccca ccccgttaat atctccttgg
     9481 gtgataccta tccttatctt gttatcttcc atgtttttat ttattagttt gttccgcttc
     9541 cttagatgct tctcccaatg gaatctgatt ctgctgaact tcattcggaa gtttcagtgt
     9601 atacagagat gcttccatct ggcgtaccag gttgcgtttc attttatcag gtgaataaac
     9661 aaatatttct gctgttataa ttcgttggtt tttctcgtcc agacgagtat gagatacata
     9721 cgggccaccc ataaagtcgc ccttcatacg ccacaggcca cgtgcttcca ttgtgtagct
     9781 gttctgtaca ttgatcggac ggacatcggt cagcaaacta tcggttgaca tataaacgcc
     9841 ttccttgaat ccggggatat tggctttcat cacggagtca cgtttgtgca caaaatattc
     9901 tttggtaaac gtatccttgt cagtgtacgg ataagagtac atcacaaagt tacggtcggc
     9961 actacctgtg ttggtagaag cccaaaagaa atcatccccg gtctttgaat tagccagttc
    10021 ggcatccacc cagatgtcgc atccgaacaa actgtccact ttctgcgaaa tgaagttact
    10081 atgcttccct tccaggaacg taatctgacg gttcatttcc gcacgggtaa agaagtcgac
    10141 aatcgtcttt ttgttctctt ccacaaactt ctcgaattct tcttcgttcg gagcctggat
    10201 agtcaatatc atctgcggat tggcatacac gtccttcgca tatttgaacg aggctttcgt
    10261 atatatatcc tgtatatcta caataataat gttacgtatc aacttcagcg tagaatcata
    10321 atctttcggt gaagtataca taatccggaa agaaggttcc gactgcggca aaccgggcat
    10381 atcagcatcg agcgcatcat gtaaagccct tccggcagca cgatcccaaa caccgtgatc
    10441 tactacaacc aaaagctcgt aagcacgacc actagaggtg tgatttcctt tcagaccaca
    10501 agatgcaacg acaaaggcta ccaaagcgat gcataaaata aaagagtact ttttcatgat
    10561 gttcggtttt atatattaac tttcattatt tttctcctgt ttcgctgtcg acagcatacc
    10621 gcaagcggca aaaatatctt cgcccctgga tgaacggata gtggtgaaaa gtccgtgtga
    10681 cgtcagataa tcacgaaaac gggtcatcgt atccatgtcc gccccctcga ggtctacccc
    10741 cggtatggca tgaaaacgaa tcagattcac cctgcaatcc agcccgcgaa gaagtttcag
    10801 caactctttg gcatagacct gcgaatcatt gagcccttta aaaacaatat attcaaacga
    10861 aagtcgacgt tgtttactaa aatcatagtt ttttaacagt tccaccattt cggtgattga
    10921 aaacgccttt tccgccggca ttaattcagc acgctgaacg gtcagcggag agtgaaggct
    10981 gatagcaagg tggcagtcat tttcttcaat aaaacgctgc aatcctttcc gtagcccgac
    11041 tgtagaaagc gtgatacgct tcggactcca tgcgtaaccg taggtagcgg tcagtagttc
    11101 caatgccttc aatacctcat ccaggttatc gagcggctcg cccattccca tcattacgac
    11161 attagtcagt ttgtcccgtt ccggcagcga atgaatctgg tttatgatct ggctggcggt
    11221 caggttagcc gtatacccct gtttgccggt catacagaac ttacagttca tcttgcaacc
    11281 tacttgtgac gacacgcaca acgttgcccg gtcatcatcc ggtatataaa ccgactctac
    11341 aaaatggttc tcacccactt tataaagata cttcaccgta ccatctacag agcgcatttc
    11401 atctaccgga gcttccgctc ccacctcata gttctgcttg agcaactccc ggtgtttcaa
    11461 tgacaaatta gtcatatcat caatcgaggc taccttcttt tcgtaaagcc aggatgcaat
    11521 ctgcttggca gcaaagccgg gcatatccag tctttttgtc aatgattgaa gctctacaag
    11581 agtcattcct aaaaggggat atttagacat tcttctttct gttgatagtt tatatctgca
    11641 aatgtaagga aataaagtcg atttccgtat agcaggaatg taaaagttaa caaaaaaggg
    11701 aagtatgcct ccgttatgat tcaaccacgc tgatatattg aagtagcttt tgcgccattt
    11761 cagaatcctc gccattcttt ttcacttcat gaccgtacgc ctcacggaaa caagccagcg
    11821 cctcttcccg ttcattacaa aagctgtgca aaacccctaa gttctgacaa gccagaatcg
    11881 tatcttcttc ctcccatccc aaatacttct ttcgcagttc gaactctctg aagaaagcct
    11941 ctttcgccat tggataattc tccaacttca cataagcctg tgctttgtaa taatatacca
    12001 gacaggaagc attagggtca gcatcatcgt gaatatccaa agacgttgca atacgaatca
    12061 cgttatcata gtctttattc atgtaatact gctgcataat atcacatctc aatgcctcgt
    12121 agcggacagt cagttccgcc agacgcggtt tttcgctgaa acacatttca tgcagaagag
    12181 actcacggaa gaataaagta gacgcctgct catcgccacg ttcattcatc atccgtttga
    12241 attccctgca tagataatac aactgtttat gacaagcgac gatctgtttt ttattatcta
    12301 tctgtatagc aatgtccaac gcctgattca tcagcatcca tgcttcatcg tatcgtttga
    12361 tataataaag acatttaccc tgcatacgca aacatttagc cactccaccg gacagtctgc
    12421 cattcaacga ctcgtgcatt tcagctactt tccggaattt ctcggcagca ctctcttcct
    12481 catccttata gtaatcacaa taagccagat attcggaaag ttcaatgact tctgcctgac
    12541 tcttctcgtc agcagaagcc gcatgataat caagcgccct attcaaatag atcgccgctt
    12601 cattgtattg ctcattgtag taatatgcca aagctagatt tcgacaggtg ttggcaatct
    12661 ccagttccgg agtcggtact atgttttcct gcatcaccaa tgctttcagg aaacagtcgc
    12721 atgccgtttc gtattcttca ttacgggcat accgacatcc ctcattcatc ttcaataccg
    12781 acttggcaat gagtggcatg gcagcacctt ccatactctt ctcactcaca gcagctgccg
    12841 ccttcgtcag atggaaagaa ctgctcaaga aagtagccat atcattagca atgacaggaa
    12901 ttaaaaaaga atcgatctca tcaaagtcca attcggcata gacttcaggc gtaacttcag
    12961 gattgtcgtt catgatcgcc ttccagctat cttccaacag aaaacgattc gtgcgataca
    13021 gaatctcgaa aatctccaca tcacaaatcc aatccttcaa tatatcccat tcttgcatct
    13081 tatagcattg ataggtaatc tccactttat agcgatacga atcatggtag cagaactgtt
    13141 tcatgcgata gttataatcg gcaaaagtca acggatggga aaggatttct tcctcatcca
    13201 gcagagcgga aataatttca tggcgactat catctataca ttcgtcatct tgagcgaaat
    13261 agcgttcgat cgcctctacc atttgtgtat caccaatgca atatcgtcct cctttgttgg
    13321 tgagccagct gctcatttcc actctcaact gcgaccaaag tatctgatta atgtctgcca
    13381 tgctcttcac ttcatcttcg gtaaatcctt ctaaagtaag tgaaagcatc agaagcgttc
    13441 ttccaatctc ttcggaacca taatcagccg acaaacgccg tagcacactg tcatagaatt
    13501 gcccaacctc attgagccgg caatatccac gcatatattc attgagagca tcgtactgac
    13561 cgaacgaaac cagctcgttg agcaatacac ttaaacagcg cggttgttca gccagcaccc
    13621 acgaagcaag aatatcttcc tgctgtgcag acaaagcctt ggagtaagta gacaaatatt
    13681 gctttgagaa cgacttggca tccgcctgtg aaaagccatt caactggaaa tgagcgta
//
