LOCUS       gnlProkkaOENCILCI_1    13549 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OENCILCI_1.
ACCESSION   gnlProkkaOENCILCI_1
VERSION     gnlProkkaOENCILCI_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 15:43:34
            Original ID  :: gnl|Prokka|OENCILCI_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1499892
            Orig. end    :: 1513441
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13549
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:8549]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8549
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13549
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13549
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             1138..2235
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     288.7; E-value: 1.1e-87)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1237"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.5e-94,
                     bitscore: 315.2, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITVTSPLLPSLDDFIPYLQDIWNRKWLTNNGYYHQELEKALCEY
                     LKVPYISLFTNGTLPLMCALQALRITGEVITTPYSFVATTHALWWNGIKPVFVDIDPET
                     CNIDPDKIEAAITPKTTAIMPVHVYGKPCDTERIQAIADKYGLKVIYDAAHAFGVEVAG
                     KSILNAGDMSTLSFHATKVYNTIEGGALICHDEKTKKRIDYLKNFGFAGETTVIAPGIN
                     GKMDEVRSAYGLLNLKQVDVAIEARRQVAIMYRKGLEHVPGITFMEDMPGVRHNYSYFP
                     IFVDSEKYGMTRDELYFKMKERNILGRRYFYPLISEFSTYRGLESAKPENLLVANRVAN
                     SVICLPIYNSLSQIEIDRVISVISK"
     CDS             2243..2785
                     /locus_tag="ctg1_1238"
                     /transl_table=11
                     /translation="MIGSTSFLTEEEIKSLGFKKYGDNLKISRFAHFYTPSTIEIGNNV
                     RIDDFCILSGNIKLGSNIHISAYCALYGAYGITMCDNTGLSPRATIFSSMDDFSGDFLI
                     GPIHDKSKINVQGGSVLLEEYVQIGSGSILFPKLKISKGCVVGAMSLVNKSLDEWGVYA
                     GIPVKKIKERRRGLLNL"
     CDS             2790..3710
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1239"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.3e-19,
                     bitscore: 67.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPLVSIICITYNQAEYLSSCLDSIFSQQVDFQVELIIHDDASTD
                     STTEIISQYIKKCPFQIKTILQKENQYSKGIDIFSKYIYPKVEGKYIAICEGDDYWTDS
                     RKLSIQIKMLEANQSFSATAHQSTVIYEKENREHLFCLLRKNIIKMDDVMGNRIFHTAS
                     FVFRSDIIPLLSIDIIPFAYDRFLFLVCSFYGDIYYFYDNMCVYRKSEIGITSHITYQI
                     HKRDLFVPKKLKEINSNFPYYRYMAYVNKAMLSSVDISLWNYICHSVTFLFYSFSYFPR
                     NIMDIYRWGYLTVWWMTKGRKFRMK"
     CDS             3767..5035
                     /locus_tag="ctg1_1240"
                     /transl_table=11
                     /translation="MDFLSKKFLYVFLFWWGAYLFCSTFNPCDLFLVSNETYIILLGYV
                     VSFLIGFSIFPIKYNHSIYKNRANILAIKTNWWYVLAGISSIIILYNYICKYLLLLEVV
                     GADEARESLFESGLLFSTNYEIYLFQFLFTPFQTIVQFFLAYCIVFKSKFPPIYLMLFV
                     LYFFLYGYLGGGRANYLALFLYVILLFVLRTQIASKLHCNIRKYSFKFTFFLFFFCAII
                     FVIVSIQTTLRKGVTDIDGQTILMGFEELLSQFVWYMLGPIRALDYAFEYQYDSFLGLW
                     YGRATVGGFDTLLKMFIHALGGSYTTANQVIGGYLQEHLITVGYGITFNFAYTALIFYY
                     LDFGYFGILLWPFFLGITTRFTVYKFQKKATFARLILMLFFFYTAIFATFSWTFYKTAS
                     VVLIILLIIYQKYEQKSLCRHEC"
     CDS             5001..6302
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 205.9;
                     E-value: 1.2e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1241"
                     /sec_met_domain="CTP_transf_like (E-value: 1.2e-12,
                     bitscore: 46.1, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.8e-118, bitscore:
                     392.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 8.7e-63, bitscore:
                     209.9, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKVYVGMSADIIHPGHLNIIHEAQKYGSVTVGVLTDAAIASYK
                     RLPYLTYEQRSLIVKNLKGVEEVIPQTTLDYVPNLELIKPDFVVHGDDWKDGIQKETRQ
                     RVIDTISKWGGKVIDVPYTKGISSTQLNTQLKEIGTTPEIRLKRLKRLISAKKIVRICE
                     SHSGLTGLIIENTSVEVNGIKREFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDLNDAL
                     ECTTKPVIFDGDTGGKIEHFVFTVRTLERLGISAVIIEDKIGLKKNSLFGTDAVQTQDT
                     IEGFCDKIKAGKRAQITADFMIIARIESFIAGKGLDDAMERALAYIEAGADGIMIHSKD
                     KSGKDIREFCMTLRKKHKSIPIVVVPTTYNHITEDELASWGVNVVIYANHMLRSAYPAM
                     LNTAKSILANARSYEANDLCMPVKEILELIPGTK"
     CDS             6341..7471
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 61.2;
                     E-value: 1.3e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1242"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.3e-16, bitscore:
                     57.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.5e-18, bitscore:
                     63.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISSKFFIDSLCSMQMDFFTGVPDSLLKNVCAYITDHFVTERNVI
                     AANEGAAVGLAAGYYLATKKIPVVYMQNSGLGNAVNPLMSLTDKEVYNIPLLLLVGWRG
                     EPGVKDEPQHIKQGKVTLPLLEAMGIKYAIMSQNETEFLSQLNYANFYMNETHEPFAFV
                     IPKGTFEEYKLQQDGEVILPLKREAAIQLIASSLSKEDIIVSTTGMISRELFEYRTSAF
                     MEHEKDFLTVGSMGHASQIALGIALEKKKCKVFCFDGDGSTLMHMGSLAIIGSLHPDNY
                     VHVIFNNGAHDSVGGQPTVAFNIDLCKIAQACGYEAALSVSDSDSLCEALKRITYMHGP
                     ILLEVKVRKGARKDLGRPTTTPLQNKDTFMLFLNNQ"
     CDS             7476..8549
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1243"
                     /sec_met_domain="Fe-ADH (E-value: 3.9e-72, bitscore: 241.0,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQRCFLGESSIENLLLVLKEFSFSHLFLVRGRNSYETCGAKSIM
                     TAVFSELDCEVTEYFDFEENPKIEDLERGLLLLRKYSCSVIVAVGGGSVLDMAKLLRFF
                     YSYSGEPTSGKFEKEKDLLPLIVLPTTAGTGSEATHFAVLYKNKVKYSVEHNAILPDVA
                     IVYPPFTYNTPRYLTACAGFDALAQAIEAYWNAYATKESDEFAKRAIELLWPNLPLVVN
                     SPTNSMRNKVSEGAYWAGRAINITKTTAPHAFSYSFTTYYGYPHGHAVAMTFPFFWSIN
                     MDIHRIRKNISPSLYKQKIEYLKNLCNIDIGDYIEKRILLPLKLPENFNKYFILESVNR
                     QRLQNNPVDLDDFSELF"
     CDS             8558..9349
                     /locus_tag="ctg1_1244"
                     /transl_table=11
                     /translation="MKELSCDEFKQIQIQILSEIKIFCEKNGLNYYLAYGTLLGAVRHQ
                     GFIPWDDDIDIVMPRIDYLKFEKLFKHDRFEFLSISKDATYPYHFGKVLDKNTILVDDS
                     SSSYDIGVNIDVFPIDGLPSSEMRKRIHCHFVWFLQNIATLKLMKYVRKRGMIKNIILA
                     FLKFIFIPFPLYTVLKAINNYAMKYSMEKSSEYLLEGAYKNREVVCASIFQSKMNVVFE
                     NESYSAPVGTNSWLMQLYGNYMEMPPVERRISTHNYKVLQK"
     CDS             9346..10038
                     /locus_tag="ctg1_1245"
                     /transl_table=11
                     /translation="MNQKEKEWLASLLLVRDILDRFSIKYILDTGTLLGAVRDRAFIPW
                     DDDIDIAIIDFLFDKHLAKTIGRELYLVGFDVIITANTVHLRRCNCEINLKSYLRNGTF
                     YNSTMTKVEGSDLLYSIYNCLRRLALYRNSHSFSRQVVNFIYFIISFMNYLGGAFLQDL
                     LIAKSKPKIRKIVIPAYLLSNTKDILFYDEYFKVPIDVNEYLTLRYGKNWNIPNRNYNY
                     ITDDLSLK"
     CDS             10050..11273
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 67.2;
                     E-value: 2.6e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1246"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1e-17, bitscore:
                     62.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTLLQISIEVNSGSVGRIAEQIGQVALAHGWKSYITYARNHLPS
                     QSMTIKIGTKWDVYWHGIMTRLFDTHCLHSTRATRRLIQQIEEIHPDIIQLHHIHGYFL
                     NMEVLFKYLSSISTPVVWVFHDCWSMTGHCAHFDYVGCEKWLTHCETCVQKKIYPGSVL
                     IDRSFKNYELKKKLFTSMENLTIVPVSQWLGMIVKKSFLKNYPINVIQNGIDLKLFSPQ
                     SLQSVCAMRNKLGLAEQTSVLLGVASIWDKRKGLEDFVQLYNMISEDWVIVLVGLSKTQ
                     LKEIPDGIIGIERTENVTQLATLYTLASVFINPTWEDTFPTTNLESLACGTPVITYRTG
                     GSVESVSDETGYIVEKGDIKGIKRAVAEIVKRGKEVYHHICRKRAVKYYDKNERFEDYI
                     KLYDTLLK"
     CDS             11282..12424
                     /locus_tag="ctg1_1247"
                     /transl_table=11
                     /translation="MDKNYQVCTHCVMDTTDSNLTFDENGVCDRCREYEQHILPWWNHG
                     KGHEVELKAILEQVRISGKGKKYDCILGLSGGLDSCYMLHLAVKEWGLRPFVFHIDAGW
                     NLPVAEENIKKLCDKLNVHLHIQKLDFEELKQMQIAFFKTGHAGLDVPQDHAFIAQIDK
                     YSEELGVKYILNGYNICTEIVADPDSWFDGAGPTADKTYVKDVLKKHGNVKTKNYIYTT
                     GFKHKFVLPYIKGVKTLQLLNYVPFTKAEMLATLQREYDYQPYGQKHFEDLLTKFLEAW
                     WLPTRFGYDIRRAQLSSLIITGQMSREEALEILKNPPASDEECKKMFDEVAEKLAISKE
                     ELMSYHKLPKKYLHYKNNAWAFKIGIRLYQLLGLDKRIRK"
     CDS             12443..13516
                     /NRPS_PKS="Domain: NAD_binding_4 (10-144). E-value:
                     2.6e-07. Score: 21.9. Matches aSDomain:
                     nrpspksdomains_ctg1_1248_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 105;
                     E-value: 8.3e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1248"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.5e-106,
                     bitscore: 353.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.4e-06, bitscore:
                     24.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIFKDKVLLITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQD
                     DMRHHLQNPKVKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVI
                     GTDNVLESAIAHGVKNVVVLSTDKAAYPINAMGISKAMMEKVAIAKGRALGEEAGTTIC
                     CTRYGNVMASRGSVIPLWVEQIKNGRPITVTDPNMTRFMMTLDDAVDLVIYAFEHGHNG
                     DLFVQKAPAATLDVLAQALKETYAQVDPKYGETEVKTIGTRHGEKLYETLVTREEMAKA
                     VDMGDYYRIPCDTRDLNYDKFFTEGNEDIARIEDYHSHNTARLDVEGMKNLLLKLRFIR
                     EDLGMEEKAKSAEIKSE"
     CDS_motif       12470..12526
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_1248_0001"
                     /evalue="1.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg1_1248"
                     /protein_end="28"
                     /protein_start="9"
                     /score="11.1"
                     /tool="antismash"
                     /translation="LITGGTGSFGNAVLRRFLD"
     aSDomain        12473..12874
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_1248_NAD_binding_4.1"
                     /evalue="2.60E-07"
                     /label="ctg1_1248_NAD_binding_4.1"
                     /locus_tag="ctg1_1248"
                     /protein_end="144"
                     /protein_start="10"
                     /score="21.9"
                     /tool="antismash"
                     /translation="ITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQDDMRHHLQNPK
                     VKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVIGTDNVLESAI
                     AHGVKNVVVLSTDKAAYPINAMGISKAMME"
ORIGIN
        1 gttaagggta atagggctga ttctgattgt taatgcattg ggtatcattc cccgtaccat
       61 attagtaaga ggtattgatt ttaagacaca gaccaaagta tccataatct cttctgtttc
      121 aagtggattg gttggcgtag gcatggctat agtgggcttt ggggtatgga gcttggtgtg
      181 gcaacagctt tcccggcaga tgctgaattc tctgtttctt tggatattct gtaaatggat
      241 gccccaatgg gaattctccg taaaaagctt caaggaaatg ttcggctttg gctataagct
      301 cttgttgtcc ggattattgg atactcttta caagaatgtt tattatgtgg ttataggccg
      361 ttgttacagt tctgcacagt tggggcaata tactcgtgca gagcagttca atacgatatt
      421 ttccagtaat ctgaccagta ttgtccagcg tgtcagttat ccggtgctta gttccattca
      481 agaagaaccg gagcgcttgc gcgaagctta tcggcagata ataaagacta caatgcttgt
      541 gacattcgct tgcatgctgg gacttgcagc tgtggctaaa cctttgatta taattctgat
      601 cggtgagaaa tggttgactg ctgtttcctt tctgcagatt atttgtttca gtggtatgct
      661 ttatccgctt catgccatca atctgaatat cttgcaggtg aaaggacgtt cggacttgtt
      721 tctgaaatta gaaatcataa agaagaccat tgcggtgttt cctattctga taggtatttt
      781 ttatggcatc gaatatatgc tgtgggggag tgtcttaacc tctttcatag cctatttctt
      841 aaatagccac tattctgccg acttgatacg ctattctacc atagaacaaa tcaaggatgt
      901 gcttccggtt tttgcagttt ctttgacaat tgctgctgtc atgtggcttt tctccttatt
      961 ggatatatcc gtttatattc aattacccat tcagattatt gttggtttga cattagcttt
     1021 tgctgtttat gaaagattaa gattaccaga gtatcttgag gtaaaacggc ttgggttgtc
     1081 ggctcttcac aaaaaataga aatcagtata tatttttata gtaagatgga aaataaagtg
     1141 attacagtta cttctccatt acttccttcg cttgacgatt tcattcctta tttacaggat
     1201 atttggaacc gtaagtggct gaccaataac ggttattatc atcaagaatt ggagaaagcc
     1261 ttgtgtgaat atttgaaggt gccttatatc agtcttttta ccaatggcac actgcctttg
     1321 atgtgtgctc tgcaagcatt gcgtattact ggtgaggtga taacaactcc gtatagcttt
     1381 gtagctacca cccatgcttt gtggtggaat ggaatcaaac cggtatttgt ggatattgat
     1441 ccagaaactt gtaacattga tccggacaaa atagaagcgg caataacccc caagacaacg
     1501 gcgattatgc cggtacatgt ttatggcaag ccttgtgata cagaacgtat ccaagcgata
     1561 gcggacaaat acggtttaaa ggtcatttat gatgctgccc atgcttttgg ggtagaagtt
     1621 gctggaaagt caattctgaa tgccggtgat atgtcaacct tgagttttca tgcgaccaaa
     1681 gtttacaata cgattgaagg tggtgctctg atttgccatg atgagaagac taaaaagcgt
     1741 atcgactatt tgaaaaattt cggttttgca ggggaaacga ctgtcatagc tccgggtatc
     1801 aatggcaaga tggacgaagt acgtagtgct tatggtttgt tgaatttgaa acaagtggat
     1861 gtagctattg aagctcgtcg tcaagtggct atcatgtatc gtaaaggctt ggaacatgta
     1921 cctggtatca cttttatgga agatatgccc ggagtccgtc ataattactc ttactttccc
     1981 atattcgtgg attctgagaa atatggcatg acacgcgatg aactttattt caagatgaag
     2041 gaacggaata tattggggcg taggtatttc tatccgttga taagcgaatt ttctacttat
     2101 cgaggattgg aatcggctaa gcctgagaat ctattagtag caaatcgggt ggcaaatagt
     2161 gtaatatgtt tgcctatata taattcttta tcacaaatag aaatcgatag agtaatatcg
     2221 gttatatcga aataatcttt ttatgattgg tagtacgtct tttttaacgg aagaagaaat
     2281 aaaatcgtta gggtttaaaa aatatggaga taatttgaaa attagtcgtt ttgctcattt
     2341 ttatacccct tctactattg aaataggtaa taatgtccgt attgacgact tttgtatatt
     2401 atctgggaat attaaacttg gatcaaatat tcatatttct gcttattgtg cactttatgg
     2461 agcctatgga ataacgatgt gtgataatac aggactttct cctcgtgcaa caatttttag
     2521 ctcaatggat gattttagtg gtgatttttt aataggtcca atacatgata aaagcaaaat
     2581 aaatgttcag ggtggttccg ttttgttaga agaatatgtg caaattggtt caggaagtat
     2641 attgtttcca aagttgaaaa tatctaaggg gtgtgtagtt ggagctatgt ctttggttaa
     2701 taaaagcctt gatgaatggg gggtatatgc aggaatacct gtaaaaaaaa ttaaagaacg
     2761 ccgtagagga ttattgaatt tatagtttta tgaagccatt ggtaagtatt atttgcatta
     2821 cttataatca agctgaatat ttatcttcat gcttagatag tattttttct cagcaggtgg
     2881 attttcaagt agaattgata atacatgatg atgcttctac agatagtaca actgaaataa
     2941 tttctcagta tatcaagaaa tgcccttttc agattaaaac tattctacaa aaagagaatc
     3001 aatattctaa aggaattgat attttttcaa aatatatata tcctaaggtc gaaggtaaat
     3061 atattgctat ttgtgaagga gatgattatt ggacggattc tcggaaacta tctattcaaa
     3121 ttaaaatgtt agaagcaaat caatcttttt cggcaacagc tcatcaatct actgttatat
     3181 atgaaaaaga aaatagggaa catttgtttt gtctattacg aaagaatata ataaaaatgg
     3241 atgatgttat gggaaatcgt atttttcata ctgcatcttt tgtttttaga agtgacataa
     3301 ttcccttgct ttcaatagac ataattcctt ttgcttatga tcgtttttta tttctagttt
     3361 gttcgtttta tggtgatata tattattttt atgataatat gtgtgtatat cgaaagagcg
     3421 aaataggtat tactagtcat ataacttatc aaattcacaa acgggattta tttgtcccga
     3481 aaaagttgaa agaaataaat tctaattttc catattatag atatatggct tacgttaata
     3541 aggctatgtt gtcttcagtg gatatctctc tctggaatta catatgccat tctgtaacat
     3601 ttttgttcta ttctttctca tactttccta gaaatattat ggatatatat aggtgggggt
     3661 atttgacagt ttggtggatg actaaaggtc gaaaatttcg tatgaaatga gtttgatagt
     3721 attctgcttt tttactctca tatttttact tttaaaaaaa agtagaatgg attttttatc
     3781 aaaaaaattc ttatatgttt ttttgttttg gtggggtgca tatttatttt gttctacatt
     3841 taatccttgc gacttatttc ttgtttcaaa tgaaacatac attatattgt tagggtatgt
     3901 tgtttctttt ttaataggtt ttagtatatt tcctataaaa tacaatcatt caatttataa
     3961 aaatagagct aatattttag ccataaaaac taattggtgg tatgtgttag caggaatatc
     4021 aagtatcatt attctatata attatatttg taagtatttg ttgttgttag aggtggtagg
     4081 tgcagatgaa gcaagagagt ctctttttga atctgggctt ctgtttagta caaattatga
     4141 gatatattta tttcagtttc tgtttactcc ttttcaaaca atagtgcagt tctttttagc
     4201 ttattgtata gtcttcaaga gcaagtttcc tcctatatat ttaatgttat ttgttctcta
     4261 tttttttctt tatggctatt taggaggagg aagggctaac tatctagctc tctttttata
     4321 tgttatattg ttatttgtac taagaaccca gattgcttca aaattacatt gcaatattcg
     4381 aaaatattct ttcaaattta cttttttcct ttttttcttt tgtgcaataa tttttgtgat
     4441 tgtttctatt caaactacat tgagaaaagg agtcactgat atagatggac aaaccatcct
     4501 tatgggattt gaagaattgt tgtcccaatt tgtatggtat atgttgggac ctattagagc
     4561 gttagattat gcttttgagt atcagtatga ttccttttta ggcttgtggt atggaagagc
     4621 aactgttggt ggatttgata cacttttaaa gatgtttatt catgcgttag gaggaagtta
     4681 tacaaccgct aatcaagtta taggtggcta tcttcaagaa catctaataa ctgtcggtta
     4741 tggtataact ttcaattttg cttatacagc attgatattt tattatttag attttggtta
     4801 ctttggaata ttgttgtggc cattcttttt gggaataaca actcggttta ctgtttataa
     4861 gtttcagaaa aaagcaactt tcgcaagatt gatattaatg ttattctttt tttatactgc
     4921 aatatttgcg actttttcat ggacttttta taaaacagct tcagtagtgt taattatatt
     4981 actaattata taccagaaat atgaacaaaa aagtttatgt cggcatgagt gctgatatta
     5041 ttcatccagg gcatttgaat attattcacg aggcccagaa atatggttct gtaactgttg
     5101 gagtattgac agatgctgct attgctagtt ataaacgttt gccatatttg acttatgaac
     5161 agcgttcgct aattgtgaag aatttgaaag gcgttgaaga agtgattccc caaacaactc
     5221 ttgattatgt tcctaattta gagttgataa aacctgattt tgtagttcat ggtgatgatt
     5281 ggaaggatgg tattcaaaaa gaaactcgtc aacgtgtcat agatacaatt tctaaatggg
     5341 gtggtaaagt gatagatgtt ccttatacaa aaggtatatc ttccacccag ttaaataccc
     5401 agttaaagga aattggtact acccctgaaa ttcgcttgaa acgtctaaaa cgtctgattt
     5461 ctgccaagaa aattgttcga atatgtgagt ctcatagtgg attaacaggt ttaattatcg
     5521 aaaatacgag tgttgaggtt aacggtatta aacgtgagtt tgatggaatg tggtctagta
     5581 gtcttactga ttctacctct aaaggaaaac cggatattga agctgttgat ttgactaccc
     5641 gtcttcatga tctgaatgac gctttggaat gtacaactaa acccgtaatt tttgatggag
     5701 atacaggtgg aaaaatagag cattttgtat ttacagttcg tactttggag cgcttaggga
     5761 tatcagcagt tattattgaa gataaaattg gtctgaagaa gaactcgctt tttggaacag
     5821 acgctgttca aacccaggat acaattgaag gtttttgcga taagataaag gctggtaagc
     5881 gtgctcagat aacggctgat tttatgataa tagctcgtat tgagagcttt attgcaggta
     5941 aaggtctgga tgatgcaatg gaacgtgcat tagcatatat tgaggctggt gctgatggca
     6001 ttatgattca tagtaaggat aaatcgggta aggatattag ggagttctgt atgactttgc
     6061 gtaagaagca taaatccata cctattgtgg ttgttcctac aacatataat catataacag
     6121 aagatgaatt agcatcatgg ggagtgaatg tagtaattta tgccaatcat atgcttagaa
     6181 gtgcatatcc cgccatgcta aatacagcaa agtccatttt ggctaatgcc cgttcatatg
     6241 aagctaatga tttatgtatg cctgtcaaag aaatattaga attgattccg ggtactaaat
     6301 aacttcgttt atattctatt aatttgagat tcttgttatt atgatatctt caaaattttt
     6361 cattgattct ctttgctcca tgcaaatgga tttctttacg ggagttcccg attctttatt
     6421 gaaaaatgtg tgtgcatata tcaccgatca ttttgttaca gaacgaaatg ttatcgcggc
     6481 caatgaggga gctgcagttg gtttagctgc aggatattat ttagccacaa aaaaaatacc
     6541 agttgtttat atgcaaaatt ccggtcttgg caatgctgtc aatcctttaa tgtcattaac
     6601 ggataaagaa gtttacaata ttcctttatt gttacttgtg ggatggcgtg gcgagccagg
     6661 agtaaaagat gagccccagc atattaagca gggcaaagtg acacttcctt tacttgaagc
     6721 tatgggtata aaatatgcca ttatgtctca aaatgaaaca gaattcttat ctcaattgaa
     6781 ttatgccaat ttttatatga atgagacaca tgaacctttc gcttttgtaa ttcccaaagg
     6841 aacttttgag gagtataagc ttcaacaaga tggagaggtg atattacctt tgaaaagaga
     6901 ggctgctatt caacttatag cttcttcatt gtcaaaagag gatattattg tctctactac
     6961 aggtatgata tcacgtgagt tatttgaata ccgtacttct gcttttatgg aacatgagaa
     7021 ggattttttg acagtaggtt ctatggggca tgcttctcaa atagcattag gcattgctct
     7081 tgagaaaaaa aaatgcaaag ttttttgttt cgatggtgat ggatcaactt taatgcatat
     7141 gggatcgctt gcaataatag gttccttaca tccagacaac tatgtacatg ttatttttaa
     7201 caatggggct catgattctg taggtggaca acccacagtt gcctttaata ttgatttgtg
     7261 taaaatagct caggcttgcg gttatgaggc agctttatct gtttcagaca gtgatagctt
     7321 atgtgaagcc cttaaaagaa ttacgtatat gcatggtcct attttgttag aggttaaggt
     7381 aagaaaagga gcacgtaagg atttgggacg tccgactact actcccttac aaaataaaga
     7441 tacctttatg cttttcttga ataatcaatg attttatgga gcagcgttgt tttttgggag
     7501 agtcttcaat cgaaaatttg ctcttagttt tgaaggagtt ttctttttct cacctttttt
     7561 tggtgcgtgg cagaaactct tatgagactt gtggtgccaa atctattatg actgctgttt
     7621 ttagtgaatt agattgtgaa gtaacggagt attttgattt tgaagaaaat cctaaaatcg
     7681 aagatttgga aagagggtta ttactattac gtaagtactc ttgttctgtc attgtcgctg
     7741 ttggtggagg tagtgtattg gatatggcta aactacttcg ctttttttat tcttattctg
     7801 gtgagcctac aagtggtaaa tttgaaaaag agaaagattt gcttccattg atagttcttc
     7861 ccactacagc cggtacggga agtgaggcga cccattttgc agtattgtat aaaaataaag
     7921 tgaaatattc tgtagaacat aatgctattt tacctgatgt tgcaattgta tatcccccat
     7981 tcacatacaa tactccgagg tatttgacag cttgtgcagg ttttgatgct ttggctcagg
     8041 ctatagaggc ttactggaat gcttatgcta caaaagagtc agatgaattt gctaagagag
     8101 caattgaact tttgtggcct aatttaccat tagttgtaaa ttctcctact aatagtatga
     8161 gaaataaagt gtcggagggg gcttattggg ctggtcgtgc tataaatatc actaaaacga
     8221 ctgcgcctca tgctttctct tattcattta caacttatta tgggtatcca catgggcatg
     8281 cagtagcaat gacatttcct tttttttggt caataaatat ggatatacat agaattagaa
     8341 aaaatatatc cccatctctg tataaacaaa agattgaata tttaaaaaat ctgtgtaata
     8401 ttgatattgg tgactatata gaaaaaagaa ttttattgcc attgaagttg ccggaaaatt
     8461 ttaataagta tttcatttta gagagtgtaa ataggcagcg attgcaaaat aatccagtgg
     8521 acttagatga ttttagtgaa ttgttttgaa acatattatg aaggagttgt cttgtgatga
     8581 atttaagcaa attcagatac aaatattgag tgaaataaaa atattttgtg aaaaaaatgg
     8641 gttgaattat tatttagcgt atggaacttt attgggagct gtgaggcatc aaggttttat
     8701 tccttgggat gatgatattg atatagtaat gcctcgtatt gattatttaa aatttgaaaa
     8761 gttatttaaa catgatagat tcgaatttct ttcaataagt aaggatgcta cttatcctta
     8821 tcattttgga aaagttttag ataaaaatac aatattagta gacgattctt cctcttccta
     8881 tgatatcggg gttaatatag atgttttccc gatagatggt ctgccaagtt cagaaatgag
     8941 aaaaagaata cattgtcatt ttgtttggtt tttgcaaaat attgcaactc ttaaattaat
     9001 gaaatatgtg agaaaaagag gaatgattaa aaatatcatt cttgcattct tgaaatttat
     9061 ttttattccc tttccattat atacagtttt aaaagctata aacaactatg caatgaaata
     9121 ttctatggag aaatcatcag aatatctttt ggagggagct tataagaata gggaggtcgt
     9181 ttgtgcttct atttttcaaa gtaaaatgaa tgttgtgttt gaaaatgagt cttatagtgc
     9241 acctgttggg acaaattcat ggcttatgca actctatgga aattatatgg aaatgccccc
     9301 tgttgaaaga cggatttcaa cgcataatta taaagtattg cagaaatgaa tcagaaagaa
     9361 aaagaatggt tagcatcctt attacttgta cgggatatat tggatagatt ctctataaaa
     9421 tatattttag atacaggtac attattgggt gcagtccgag acagagcatt tattccttgg
     9481 gatgatgata ttgatatcgc aataattgat ttcttatttg ataaacattt agcgaaaaca
     9541 ataggaagag agctctattt agtagggttt gatgtaatta ttactgcaaa tacagttcat
     9601 ctacgtcgtt gtaattgcga aataaatttg aaatcatatt tgcgaaatgg tactttttat
     9661 aattcaacaa tgacaaaagt agaaggatct gatttattat attcaattta taactgttta
     9721 agacgacttg ctctttatag aaactctcat tctttttctc gtcaagtagt gaattttatt
     9781 tattttataa tttcgtttat gaactattta ggtggggctt ttttgcagga tttacttata
     9841 gctaaatcta aacctaaaat tcgtaagatt gtaattcctg cctatttgtt gtcgaataca
     9901 aaagatattc tcttttatga tgagtatttt aaagttccaa ttgatgtgaa tgaatatttg
     9961 actttacgat atggcaagaa ttggaatatt cctaatagaa attataatta tataacagat
    10021 gatttatccc taaaatagtt ttaatcttta tgcttactct tcttcaaatt agtatagagg
    10081 tgaattctgg ttctgtagga cgtattgctg aacaaatagg gcaagtagct cttgcacatg
    10141 gttggaagag ttatataact tatgctcgta atcatttgcc tagtcaatct atgactatta
    10201 aaataggtac aaaatgggat gtgtattggc atggaattat gacacgtttg tttgatactc
    10261 attgtcttca ctctactcga gccactagaa gattaataca acagattgag gaaattcatc
    10321 ctgatattat tcaacttcat cacattcatg ggtatttttt gaatatggag gttttattta
    10381 agtatttatc ttctatttct acacctgtgg tatgggtttt tcatgactgt tggtcaatga
    10441 ctgggcattg tgctcatttt gactatgtcg gatgtgagaa atggttgacg cattgtgaga
    10501 cttgcgtaca aaagaaaata tatcctggaa gtgtattaat agataggtct tttaaaaatt
    10561 atgaactaaa aaaaaagttg tttacatcta tggaaaattt gactattgtg ccggtatcac
    10621 agtggctagg aatgattgta aagaaatcat tcttgaaaaa ttatccaata aatgtaattc
    10681 aaaatggaat tgatctaaaa cttttttctc ctcaatcctt gcagagtgta tgtgccatga
    10741 gaaataaatt gggattagca gagcaaacta gtgttttatt aggagtagct agtatttggg
    10801 ataaacgcaa ggggcttgag gatttcgttc aattgtataa catgatttct gaagattggg
    10861 ttattgtttt agtgggatta tcaaaaacac agttgaaaga aatccccgat ggcataattg
    10921 gaattgagag aactgaaaat gttactcaat tagctacttt gtacacttta gcttctgtct
    10981 ttattaaccc aacttgggaa gatacatttc caacaacaaa tctagaatct ttagcttgtg
    11041 gaacacctgt cattacatat cggactggcg gaagtgttga gtctgtatca gatgaaactg
    11101 gatatattgt agaaaaaggg gatataaaag gcataaagag ggctgtagct gaaatagtaa
    11161 agcgaggaaa agaagtttat catcatatat gtcgaaaacg agctgttaaa tattatgata
    11221 aaaatgaacg ctttgaagat tatataaaat tgtatgatac tttgttaaag tagaaaagag
    11281 tatggataaa aattaccaag tatgtaccca ttgtgtaatg gatacgactg attctaatct
    11341 gacttttgat gaaaatggtg tatgtgacag atgccgagag tatgaacaac atatattacc
    11401 ttggtggaac catggcaaag gccacgaagt tgagttgaaa gccattttgg agcaagtaag
    11461 aatctcagga aaaggtaaaa aatacgattg tattttagga ctgagtggtg gattggatag
    11521 ttgttatatg ctgcatcttg cagtcaaaga gtgggggctt cgtccctttg tgtttcatat
    11581 tgatgccgga tggaatctgc ctgtagcaga agagaatatt aaaaagctct gtgataaact
    11641 gaatgtccat cttcatattc agaagttgga ttttgaagag ttgaagcaga tgcagattgc
    11701 atttttcaag accggacatg ccgggttgga tgttcctcaa gaccatgctt tcattgctca
    11761 aatagataaa tattcggaag aattgggtgt gaaatacatt ttgaatggtt ataatatttg
    11821 tactgaaatt gttgctgacc cagactcttg gtttgatggt gcaggaccta cggcagataa
    11881 aacctatgta aaggatgtat taaaaaagca cggcaatgtg aagactaaga attatattta
    11941 tactacaggt tttaaacata aatttgttct tccatacata aaaggagtaa agacgttgca
    12001 actcctaaat tatgttcctt ttacaaaagc tgaaatgttg gcaacccttc aacgtgaata
    12061 tgattatcaa ccttatgggc aaaaacattt tgaggatttg cttactaagt ttctagaggc
    12121 ttggtggctt cctactcggt ttggctatga tattcgtagg gcgcaattat caagtttgat
    12181 tattacggga caaatgagcc gtgaagaagc tcttgaaatt ttaaagaatc ctcctgcttc
    12241 tgatgaggag tgtaaaaaga tgtttgatga agtggcagag aaactggcta ttagtaagga
    12301 agaactaatg tcatatcata aattgccgaa aaaatacttg cactataaga ataatgcctg
    12361 ggcatttaag attggtatta gactttatca actattggga ttggataaaa gaattagaaa
    12421 ataggaaaaa tattagtgag ttatgtctat attcaaggac aaagttttat taatcaccgg
    12481 aggcaccgga tcttttggta acgctgtatt gcgtcgtttt cttgatagtg acatcaagga
    12541 aatccgtatt tttagccgtg acgagaaaaa gcaggatgac atgcgtcatc acctgcaaaa
    12601 tcccaaagta aaattctaca ttggtaatgt ccgtgaccgc cagtctgtgg acggtgccat
    12661 gatgggagtg gattatgtgt tttccgccgc cgccttgaag caggttccca gttgcgagtt
    12721 tttcccgttg caggctgtgc agaccaatgt gatcggtacc gacaatgtac tggaatccgc
    12781 catagcgcat ggtgtaaaga atgtagtagt gctttctacc gacaaggctg cctatcccat
    12841 caatgccatg ggcatcagca aggccatgat ggagaaggtt gccatagcca agggccgtgc
    12901 gctgggtgaa gaggcaggaa cgaccatctg ctgcacccgt tacggcaatg tgatggcaag
    12961 ccgcggttct gtaataccgt tgtgggtgga gcagataaag aacggcaggc ccattacggt
    13021 aacggacccc aacatgaccc gcttcatgat gacgctggac gatgccgtgg atttggtaat
    13081 ctatgcgttt gaacacgggc ataacggtga cctgttcgtg cagaaggctc ctgccgccac
    13141 cttggatgta ctggcgcagg ccttgaagga aacatacgcg caggttgatc cgaaatacgg
    13201 tgagacggag gtgaagacca tcggcacgcg ccacggcgag aaactgtatg agacactggt
    13261 aacccgcgaa gagatggcaa aggctgtcga catgggcgac tactaccgca tcccctgcga
    13321 cacccgtgac ctgaactatg acaagttctt cacggaaggc aatgaggata ttgcccgtat
    13381 agaggactat cacagccata acaccgcccg cctggatgtg gagggcatga aaaatcttct
    13441 tttgaaactc cgcttcatcc gtgaagacct cggaatggag gaaaaggcga agagcgcgga
    13501 aatcaagagt gaataagtct ttaatttgaa taatacaaca ggaaagaaa
//
