GCA_033344695.1 - 9 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaJEGGKGOF_9 (original name was: gnl|Prokka|JEGGKGOF_9)

Region	Type	From	To	Most similar known cluster		Similarity
Region 9.1	RaS-RiPP,lanthipeptide-class-iv	41,354	59,619

gnlProkkaJEGGKGOF_10 (original name was: gnl|Prokka|JEGGKGOF_10)

Region	Type	From	To	Most similar known cluster		Similarity
Region 10.1	T3PKS	1	25,080

gnlProkkaJEGGKGOF_12 (original name was: gnl|Prokka|JEGGKGOF_12)

Region	Type	From	To	Most similar known cluster		Similarity
Region 12.1	RiPP-like	36,066	51,479

gnlProkkaJEGGKGOF_13 (original name was: gnl|Prokka|JEGGKGOF_13)

Region	Type	From	To	Most similar known cluster		Similarity
Region 13.1	RiPP-like	37,482	43,914

gnlProkkaJEGGKGOF_23 (original name was: gnl|Prokka|JEGGKGOF_23)

Region	Type	From	To	Most similar known cluster		Similarity
Region 23.1	lanthipeptide-class-iv	18,723	30,953

gnlProkkaJEGGKGOF_24 (original name was: gnl|Prokka|JEGGKGOF_24)

Region	Type	From	To	Most similar known cluster		Similarity
Region 24.1	RiPP-like	18,489	29,939	ubericin K	Other	12%

gnlProkkaJEGGKGOF_46 (original name was: gnl|Prokka|JEGGKGOF_46)

Region	Type	From	To	Most similar known cluster		Similarity
Region 46.1	lanthipeptide-class-iv	1	10,114

gnlProkkaJEGGKGOF_56 (original name was: gnl|Prokka|JEGGKGOF_56)

Region	Type	From	To	Most similar known cluster		Similarity
Region 56.1	NRPS-like	1	6,636

gnlProkkaJEGGKGOF_59 (original name was: gnl|Prokka|JEGGKGOF_59)

Region	Type	From	To	Most similar known cluster		Similarity
Region 59.1	RaS-RiPP	1	4,824

Region	Type	From	To	Most similar known cluster	Similarity
Region 9.1	RaS-RiPP,lanthipeptide-class-iv	41,354	59,619
Region 10.1	T3PKS	1	25,080
Region 12.1	RiPP-like	36,066	51,479
Region 13.1	RiPP-like	37,482	43,914
Region 23.1	lanthipeptide-class-iv	18,723	30,953
Region 24.1	RiPP-like	18,489	29,939	ubericin K	Other	12%
Region 46.1	lanthipeptide-class-iv	1	10,114
Region 56.1	NRPS-like	1	6,636
Region 59.1	RaS-RiPP	1	4,824

Compact view

gnlProkkaJEGGKGOF_9 - Region 1 - RaS-RiPP,lanthipeptide-class-iv

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Location: 41,354 - 59,619 nt. (total: 18,266 nt) Show pHMM detection rules used

Region on contig edge.

RaS-RiPP: (PF04055 and TIGR01716)
lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

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core biosynthetic genes

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KnownClusterBlast

Lanthipeptides

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		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Lanthipeptides

Core peptide predictions

No core peptides found.

gnlProkkaJEGGKGOF_10 - Region 1 - T3PKS

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Location: 1 - 25,080 nt. (total: 25,080 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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resistance

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Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaJEGGKGOF_12 - Region 1 - RiPP-like

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Location: 36,066 - 51,479 nt. (total: 15,414 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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KnownClusterBlast

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Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaJEGGKGOF_13 - Region 1 - RiPP-like

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Location: 37,482 - 43,914 nt. (total: 6,433 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene overview

KnownClusterBlast

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Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaJEGGKGOF_23 - Region 1 - lanthipeptide-class-iv

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Location: 18,723 - 30,953 nt. (total: 12,231 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Lanthipeptides

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		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Lanthipeptides

Core peptide predictions

No core peptides found.

gnlProkkaJEGGKGOF_24 - Region 1 - RiPP-like

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Location: 18,489 - 29,939 nt. (total: 11,451 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Similar known gene clusters from MIBiG 3.1

gnlProkkaJEGGKGOF_46 - Region 1 - lanthipeptide-class-iv

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Location: 1 - 10,114 nt. (total: 10,114 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Lanthipeptides

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		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg46_4

ctg46_2

Leader:

MSEEILMLQSMSVEEEINEVN

Core:

GQRFSTMSNYHCGGANFSLASNHYCRRK

Core with dehydrations:

GQRFDhaDhbMDhaNYHCysGGANFDhaLADhaNHYCysRRK

antiSMASH-DB 4.0 matches for ctg46_2

100.0% NZ_JADNKH010000035.1and 1 other:

NZ_OU540596.1 Lanthipeptides: JQ838_RS08065_lanthipeptide

Lanthipeptides: I2E19_RS11270_lanthipeptide

1

GQRFSTMSNYHCGGANFSLASNHYCRRK

28

GQRFSTMSNYHCGGANFSLASNHYCRRK

1

GQRFSTMSNYHCGGANFSLASNHYCRRK

28

42.9% NC_012470.1and 5 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10335_lanthipeptideNZ_CP065058.1 Lanthipeptides: I2434_RS07250_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS00510_lanthipeptideNZ_LS483328.1 Lanthipeptides: DQL47_RS07600_lanthipeptideNZ_LS483368.1 Lanthipeptides: DQM56_RS07295_lanthipeptide

Lanthipeptides: SZO_RS10195_lanthipeptide

1

GQRFSTMSNYHCGGANFSLASNHYC

25

G RFST S CG N+S S C

1

GMRFSTTSLSWCG--NWSAISAFGC

23

39.3% NZ_KB946328.1: Lanthipeptides: UC3_RS18350_lanthipeptide

1

GQRFSTMSNYHCGGANFSLASNHYC

25

G RFS++S CG N S S C

1

GARFSSLSGGSCG--NLSSVSIWDC

23

with 4 more sequence matches

35.7% NZ_MSKU01000037.1: Lanthipeptides: allorf_43371_43508_lanthipeptide

4

FSTMSNYHCGGANFSLASNHYC

25

ST+SN HC G S + YC

1

ISTISNEHCWGWP-SAVTTRYC

21

32.1% NZ_CP084108.1and 2 others:

NZ_CP102383.1 Lanthipeptides: NP781_RS20720_lanthipeptideNZ_JAASJR010000006.1 Lanthipeptides: HCH28_RS14710_lanthipeptide

Lanthipeptides: LCP48_RS21615_lanthipeptide

4

FSTMSNYHCGGANFSLASNHYCRR

27

+ST SN+ C G S+ S C +

2

YSTTSNFLCIGTP-SMMSQFTCSK

24

21.4% NZ_JACHIN010000025.1: Lassopeptides: allorf_47202_47381_lassopeptide

12

CGGANFSLASNHYCR

26

CGG ++ +YCR

3

CGGPHWEWIYPNYCR

17

14.3% NZ_LR134504.1and 1 other:

NZ_LR134504.1 Lanthipeptides: allorf_1623800_1623958_lanthipeptide

Lanthipeptides: allorf_1623800_1623958_lanthipeptide

1

GQRFSTMSNYHC

12

G RF T + Y C

1

GSRFETTAQYSC

12

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg46_2 - Class III

Cleavage pHMM score: 1.30

RODEO score: 0

Monoisotopic mass: 3101.4 Da

Molecular weight: 3103.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3121.4 Da N = 1; 3139.5 Da N = 2; 3157.5 Da N = 3

gnlProkkaJEGGKGOF_56 - Region 1 - NRPS-like

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Location: 1 - 6,636 nt. (total: 6,636 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

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NRPS/PKS domains

KnownClusterBlast

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

No matches found.

NRPS/PKS substrates

NRPS/PKS substrate predictions

ctg56_3

Search NORINE for peptide: strict or relaxed

AMP-binding (6..388): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVTSCALIYK
Nearest Stachelhaus code(s):: Ala DVTNFALIYK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

gnlProkkaJEGGKGOF_59 - Region 1 - RaS-RiPP

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Location: 1 - 4,824 nt. (total: 4,824 nt) Show pHMM detection rules used

Region on contig edge.

RaS-RiPP: (PF04055 and TIGR01716)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.