LOCUS       c00039_gnlPro..        14944 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GLBDOHBD_39.
ACCESSION   c00039_gnlPro..
VERSION     c00039_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 15:23:47
            Original ID  :: gnl|Prokka|GLBDOHBD_39
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14944
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14944
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3225:12010]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3226..12010
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14944
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14944
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             3..827
                     /locus_tag="ctg39_1"
                     /transl_table=11
                     /translation="VYHYHLHVVYVPVVEKQILWSKRCKDKALVGTVKETVMQVSRSKK
                     WASKPLLDDAGKPVLQKNGKPVLKKSYSILQDDFFNYMRSAGYADVERGERGSTEEHLT
                     VTQFKVQREQERLDSLTAQIDQKEQHLTQTSKTLSKKEKELAAVQKKATLTKETLIHAR
                     DLDYIGKRTFLGNYSLTEEEFSKLKKQADHGYMMDVENRRLKEELSAAKKESARWSSKY
                     HDLWYDVKPYLDALHRAPELVRSFLEKVLVSKQERTVDTQQRNLHRGQDIEL"
     CDS             845..1024
                     /locus_tag="ctg39_2"
                     /transl_table=11
                     /translation="LSKKKKSVNKSGYPDEAIKSLARCFYPSMVEFFNSEEGQREYEEW
                     LKEQEALNAAPIAA"
     CDS             complement(1074..2063)
                     /locus_tag="ctg39_3"
                     /transl_table=11
                     /translation="MENLVTSASSDKTLTTEYLRNANALLALLHGKSDSVCRFFDKEII
                     VDINQLDSLNSLILEKLSLHNVSTITTSIDVSLIDKRTLSYKAWEDFKKENFNAINSAT
                     KSIFIQWDFFAEFKNYKVPQRHTLNVRITSGLQPSDMFKVLLNGALDERDDFDLQCCTT
                     VCKVDFINNALAEELLNVVQRWTELCESACSEKGHIRPFLFKYRSGLANFVEVCAIFSF
                     CTVIAIIVKLLIYYHLIDFQVENTACLLIFLIPLATISEKVGRFFGKIIYSELSDLMDT
                     HIFRISLGDSKQAQKITEKSHYRKSAGVFAFNIATSIILPFVFFLLGR"
     CDS             2508..3179
                     /locus_tag="ctg39_4"
                     /transl_table=11
                     /translation="MESTISAAPQISIDREKTLRSHWRYWVLRRAQDIVFSLLALILLA
                     PLALLISLAIVLDSPGDGAIFRQRRVGRDGKLFWLYKFRTMCPDAEEQLNELLSQNQMD
                     GPVFKIKDDPRITRVGRFLRKTSLDELPQLLNVLRGDMSIVGPRPALPREVELYSDYQR
                     QRLYVTPGLSCYWQIAPHRNEMSFDEWVALDLKYIQERSFWVDWKIIFLTVRAMLMKYG
                     E"
     CDS             complement(3226..4884)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_5"
                     /sec_met_domain="ILVD_EDD (E-value: 6.3e-224, bitscore:
                     734.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSDNVTKGSERAPNRSLFYALGYTPEELERPLIGVVSAYSEIVP
                     GHMNLDKIAEAVKAGVQMAGGTPILIPAIGVCDGIAMGHVGMKYSLASRELICDSVETM
                     LMAHQLDGLVLVPNCDKIVPGMVMAAVRMDVPAVVCSGGPMLAGTYGGEEVSLSKMFEA
                     VGAYKAGMITDEQLEDCTCNCCPSCGSCSGMYTANSMNCLCEAIGIALPGNGTIPAVYS
                     KRLQLAKHAGMAVMEMVRKGITARQIINERSIRNALTCDMALGCSTNTVLHLLAIAYEA
                     GVPIDLKLFNEISAKTPNLCHLAPAGPTHMPDLYAAGGIPAVQAELAKKGLLDLDVPTV
                     TGKTLGENIKGAHILNEKAIRPIENPYSETGGLQILWGNIAPDGCVVKRSAVAPEMQKH
                     AGPARVFNSEEEAIAAIYAGKIVPGDVVVIRYEGPKGGPGMREMLNPTSALAGMKLDKT
                     VALITDGRFSGASRGAAIGHVSPEAASGGPIGLIEEGDTISIDIPNASITLEVSDAVLA
                     ERKAKYVAPEPNIKTGWLSRYARMVTSANLGAVLK"
     CDS             complement(5051..6070)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_6"
                     /sec_met_domain="IlvN (E-value: 7.1e-75, bitscore: 240.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1e-65, bitscore: 210.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIKKYYDSDCNLGVLDGKTVAVIGFGSQGHAHSENLAESGVNVV
                     VGLRKGSAHWAKASEFAATHDNFKVMEVEEAAKAGDVVMMLVPDELCADIYNTQVAPYM
                     TEGKALAFAHGFNIHFKTITAPKNVDVIMIAPKGPGHIVRRLYTEGEGCPSLICVEQDY
                     TGKAKDIALAYASGIGAGRAGILQTTFKEETETDLFGEQAVLCGGVSELIHAGFDTLVE
                     AGYEPEMAYFETCHEMKLIVDLINEGGFSKMRYSISNTAEYGDYRTGKRLITEETRKEM
                     KKVLTEIQDGTFASEFLTEMSPKGGRKVHFLAKRRMEAELPIEKVGAELRSMMSWLKK"
     CDS             complement(6169..6732)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_7"
                     /sec_met_domain="ALS_ss_C (E-value: 1.8e-28, bitscore:
                     88.6, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESDQRRVISLLVDNQSGVLARVSSLFCRRGFNIDSLTVSATNDP
                     AVSRITVTITSDEKALQQLVLQTERLEVTRQVFVLDSEKSLERELLLLKVESDVHNRTE
                     LREIACIYKAKIIDLSPDSMVFELIGRPDKLDAFLKMFEGYNILEQCRTGVTALERGGM
                     HQHIQKPPQEVRSVQLPPPGARRA"
     CDS             complement(6748..8412)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.3e-52, bitscore:
                     165.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLNGSQIFVEVLCEQGVDTLFGYPGGAVLNLYDELYKNADRITH
                     VLTAHEQGAAHAADGYARATGRTGVVLATSGPGATNLVTGIATAYMDSVPMVAFTGNVP
                     TSSIGRDGFQEAYIEGITVPITKHNFTVRRVEDLADTMRAAFRIAQSGRKGPVLVDIPK
                     DVTAAVCEFTPKQPEPIRTVTTYNEEQVHWAADLINAAQRPLVYFGGGVRSAASCQPLR
                     DLLHKAEIPATYTLMAAGVVPYGDPMNLGMLGMHGCYTSNRAVAECDVLIAVGTRFSDR
                     VALNPKTFAKNATIIQIDIDASELGKNVDVDLSIVGDAAYVLNAMLPQIKPAKHPEWMK
                     MIQSWQAQDYHPVSDPTRLMPHQVIGEVCNQCGPDAVYVTDVGQHQMWAAQYLRHTKSR
                     GFITSGGLGTMGFGYGAAIGAQMALGRQQRVVMFTGDGSFHMNLNEACTAVSYELPIIT
                     VIFNNSVLGMVRQWQTTFYGKRYSQTDPHRKTDFVKLADGFGLKGYRCTNLPEFQKAFA
                     DALQQKGPTWIECIIDKDEKVLPMIPGGGDINDIIME"
     CDS             8937..10154
                     /locus_tag="ctg39_9"
                     /transl_table=11
                     /translation="MKLREWNAHLHGLVVFRALLNDPVVAKLLDLTDRMEAGCSSYGPV
                     CDAVAAFEAALFEYTTNWGSYLSNAVLEAETICVRQAAAGQLDALLQSALDSELQFLQQ
                     LCGLTLDELFQTAYSEQAQRPELAFLPRWQTCELDLAAAYAQRMSEVGKKGYGMFAKHH
                     VFTVENGQLVPVKYPDPQRLSELPGYEKEREKVIANTKALLAGMPANNVLLYGDAGTGK
                     SSAVKAIANEFAPEGLRLVEVKKNQLYQIPDLMDKLAANPLKFILFIDDLSFTANDDNF
                     AALKAILEGSVGGRAQNIAVYATSNRRHLIKETLSDRTGDDIHEADTRQELMSLSARFG
                     LTVTFQRPEKARFETILEQLAKQHNIQMPTEQLLLKAEAFALRAGGRSPRVAKQFIEQC
                     EAGVQK"
     CDS             complement(10242..10616)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Ribonuc_L-PSP"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1038:Endoribonuclease L-PSP (Score: 149.8; E-value:
                     1.2e-46)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg39_10"
                     /sec_met_domain="Ribonuc_L-PSP (E-value: 2.6e-47, bitscore:
                     149.8, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVVSTANAPAAIGPYSQALDLGNMVFVSGQLPVDPATGTMADTV
                     EQQAAQSLANLKAILAEAGLSMNNVVKTVIFLADINDFAAVNAEYAKAFAEPFPARSCV
                     QVAAIPKGAKLEIECIAVRD"
     CDS             complement(10805..12010)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_11"
                     /sec_met_domain="PALP (E-value: 4e-94, bitscore: 305.1,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTLDKIYHAAFVLKDVARKTDLIEAPKLSKDCQLYLKTENLQAT
                     GSFKVRGAYYKISQLSEEESAKGVIACSAGNHAQGVALAATRRGIRSIVCMPDGAPLMK
                     VENTKNLGAEVCLVPGTYDEAHDKAVQLQKEYDMTFIHPYDDEQVIAGQGTIGLEILDQ
                     LPDVDAVVVPVGGGGLISGIAFAIKTLRPEVKVYGVQAEGAPSMYRSLHEHKYQTLKSA
                     STFADGIQVKTPGELTYQLCEQYVDDIVTVTEDETAAAILSLMENQKLVAEGAGAVPVA
                     AVLFHKLPVEGKKVACVISGGNIDVNILNRVITRGLVMSGRKANLTIALEDKPGQLKKV
                     AEVVSRCGSNVVSVQHDGSDPNMPISSCFLKLTLETRDADQIEQIRTELTKAGFQLVSE
                     RV"
     CDS             complement(12153..13076)
                     /locus_tag="ctg39_12"
                     /transl_table=11
                     /translation="MKNFAKRISALVLAVVVSAAVLCPAAFAAQLPSLPKDQCVVDDAN
                     ALNSQVTQTIEELNAKLETNCKGAQIGVLTVQYTGNLSTEDYATEAFNAWGIGNATNNN
                     GVLILLVMESAQYADGDYYLTYGDGFRNTTLAKQASAIAQTMESDFANRDYSDAVITCA
                     NNVADTIASIYGVNLDNGSYENGGTVQPGYQGGQSSGGSTLTDILTLVVSVVLLIVIIR
                     SMAYVFASPCGWLWCFGGPRPPRGRRRGPHNPPPPGGFYGGFGGMGSGSFGGGAGRGGF
                     GGGSFGGGFGGMGGGSSHGGGGGRGR"
     CDS             complement(13073..13831)
                     /locus_tag="ctg39_13"
                     /transl_table=11
                     /translation="MANADFSQNKQTAPGGFDAGSYREKAKPEQVVTLTPRQQKLAALE
                     AKLPAAFSTRAAALALSVVVMLAAFFGFGSAKLRGKYNTARQWFTAGVAADNGYNLSEE
                     LTTRENTAANILTTASNTLGADSAEVLAAQTALNDFSACLQAVQNGGKSQSLTSLPYYQ
                     GSAMHALYQADQALGAAIDQLYAKLQEQADDPMKMGAVQGQYGQFNSAATIIGTLQYNT
                     AVYEYQNEVGGFPASVLGALSGVKEVEPFA"
     CDS             complement(13833..14831)
                     /locus_tag="ctg39_14"
                     /transl_table=11
                     /translation="MVDQFAQKIDITNSQQVLQYGSACQKKIGDFSEAALSKVSTKDLG
                     EVGDMITNLIGELKSFDANEEQQKGIMGFFKKKTSQLDALKTKYDKTETNVEKIQSMLE
                     AHQVQLLKDIAMLDKMYELNMAYFKELSMYILAGKKKLADVRANELQQAMDKAKVSGLP
                     EDAQAARDLADQCERFEKKLYDLELTRNISLQMGPQIRLLQNNNTMMAEKIQSTIVNTI
                     PLWKNQMVLALGLAHSQQAMQAERAVTNMTNDLLKKNAEALKLGTIETAKESQRGIVDI
                     ETLQQTNKSLIETLDELNKIQSEGRAKRAAAEQELTRIEDELKTKMMEIRS"
ORIGIN
        1 aagtctacca ctatcatctc catgtggtct atgtgcctgt ggtggaaaag cagatcctct
       61 ggtcgaaacg ctgcaaggac aaggcactgg tcggcacagt caaggagacc gtcatgcagg
      121 tcagccggag caagaagtgg gcatccaagc ccttgctgga cgatgccgga aagcccgtcc
      181 tgcaaaagaa cggcaagcct gttttgaaga agtcgtacag catcctgcaa gacgatttct
      241 tcaactatat gcgctctgcc gggtacgccg atgtggagcg cggcgaacgt ggcagcactg
      301 aagaacacct gaccgtcacc cagttcaaag tccagcggga acaggaacgt ctggacagtc
      361 tgaccgccca aattgaccag aaagagcagc accttaccca aaccagcaaa accctttcca
      421 aaaaggagaa agaactcgcc gcagttcaga aaaaggctac actcacgaaa gaaaccctca
      481 ttcatgcgcg cgatctggat tatatcggca agcgcacctt cctcggtaac tactcgctga
      541 ccgaagaaga attttccaaa ctgaaaaaac aggctgacca cggctatatg atggacgttg
      601 aaaaccgccg cctgaaagaa gaactttccg ctgccaagaa agaatctgcc cgttggagca
      661 gcaagtacca tgacctttgg tacgatgtga agccttatct ggacgcgctt catcgtgcgc
      721 cggaattggt acgcagcttt ctggaaaagg ttctggtttc caagcaggag cgtactgtgg
      781 atacacagca acgaaacctc catcgtggac aggatattga actttgattt tcggaggaca
      841 ctatttgagt aaaaagaaaa agtctgtaaa caaatccggc tacccggatg aagcaatcaa
      901 gtcgctggca cgttgtttct atccttccat ggttgagttt ttcaacagcg aggaaggcca
      961 gcgtgaatat gaggagtggc tgaaagagca ggaagctctg aacgccgcac ctatcgcggc
     1021 ataaaaatag caggacgctc ccggagaagg gaacgccctg ttacatatta tgatcatcgg
     1081 ccaagtaaaa agaaaacaaa cggcaaaata attgatgttg caatgttaaa agcgaacact
     1141 cctgcactct ttctgtagtg actcttctcg gtgatctttt gagcctgttt cgagtcgcca
     1201 agagaaatcc taaagatatg cgtatccatc aaatctgaca attcgctata aatgattttc
     1261 ccaaaaaatc tcccgacttt ttcggaaatt gttgctaatg gaattaaaaa aatcagtaga
     1321 catgctgtat tttccacttg aaaatcgatc aaatgataat atatcaataa tttcactata
     1381 atcgcgataa ctgtacagaa agaaaatatt gcacacactt ctacaaaatt agccaaccca
     1441 cttcgatatt tgaacaagaa aggtctaata tgtccctttt cgctacaggc cgactcacaa
     1501 agttccgtcc accgctgaac aacatttaac agttcttctg cgagtgcatt attaataaaa
     1561 tcaaccttgc atacagttgt acagcattgc aaatcaaagt cgtctctctc atcaagcgcg
     1621 ccatttagca acaccttgaa catatcgctt ggttgaagtc ctgatgttat cctcacattc
     1681 agagtatgtc gttgtggaac tttgtaattc ttaaattccg caaaaaaatc ccactgaata
     1741 aatattgatt ttgttgccga atttattgcg ttaaaatttt cttttttaaa atcctcccaa
     1801 gctttatatg acaatgttct cttgtcgatg agcgaaacgt cgatacttgt tgttattgta
     1861 gatacattat gtaacgacag cttttctaaa atcagcgaat tcaagctatc tagttggttg
     1921 atatcgacaa tgatttcttt atcaaaaaat cgacacacac tatcgctctt tccatgcagg
     1981 agcgcaagta acgcattggc gtttcgaaga tattcggtag tcaatgtttt gtctgacgaa
     2041 gcagaggtta ccaaattttc cattttaaca catcccttca tatatataat catatcctac
     2101 atcgaatttc aactactttc ccttgtttcc ttcacaggag ccttcattct ctgatccgaa
     2161 gaaaacgaaa aatccaaacc cttctccaat cggaaatagg ttcggatttt tcttgtttgg
     2221 tgggcgcggg tggattcgaa ccaccgaagc tgaaagcagc agatttacag tctgtcccca
     2281 ttggccactc gggaacacgc ccatattcag ttgttgtgca tccgtgcgcc ggacgacttg
     2341 tttattttag catgagaaaa gggttttgtc aaccaccttt tttcactttt tttcagcagg
     2401 cttactgtcc cccgcccgcc gcgcttcatc cggttgaatt gcgtcctgtt ttatgttaaa
     2461 ataatgtaaa gattctacac attttacagg caggagtggg tcattgcatg gagtcaacaa
     2521 tcagcgccgc cccgcaaatt tctatcgacc gggaaaagac gctgcgcagc cactggcgtt
     2581 actgggtgct gcggcgtgca caggacatcg tgttctccct gctggcgctg atcctgcttg
     2641 cgccgctggc actgctgatc agccttgcca tcgtgctgga cagccccgga gacggagcta
     2701 ttttccggca gcggcgggta ggacgggacg gcaagctgtt ctggctgtat aagtttcgca
     2761 ccatgtgccc ggacgccgag gagcagctga atgagctgct gagccagaac cagatggacg
     2821 gcccggtgtt caagatcaag gacgaccccc gcattacccg ggtgggacgt tttctgcgca
     2881 agaccagtct ggacgagcta ccccagctgc tcaacgtgct gcggggcgat atgagcatcg
     2941 tggggccgcg ccccgcactg ccccgggagg tagagttgta cagcgactac cagcgccagc
     3001 ggctgtacgt cacccccgga ctgagctgct actggcagat cgcaccccac cgtaacgaga
     3061 tgagctttga cgagtgggtg gcgctggatc tgaaatacat ccaggagcgc agcttctggg
     3121 tggactggaa gatcatcttc ctcaccgtcc gcgccatgct catgaaatat ggagagtgac
     3181 aaaagcgcct gttgtgcatc cgcacaacag gcgctttcgt tacgtttatt tcagcaccgc
     3241 acccagattt gcactggtga ccatgcgggc gtaacggctc aaccagccgg tcttgatgtt
     3301 gggctcgggc gcaacgtact ttgccttgcg ctcggccagc actgcatcgc tgacctccag
     3361 cgtgatggag gcgttgggga tatcaatgga aatggtatcc ccttcctcga tcaggccgat
     3421 ggggccgccg gaggccgcct ccgggctgac atggccgatg gcagcaccgc gggatgcgcc
     3481 ggagaagcgg ccgtcggtga tgagggccac tgtcttatcc agcttcatgc ctgccagcgc
     3541 agaggtgggg ttgagcatct cccgcatgcc cgggccgccc ttggggcctt cgtagcggat
     3601 gaccaccaca tcgcccggga cgatcttgcc cgcgtagatg gcggcgatgg cttcctcctc
     3661 gctgttgaac acccgcgccg ggcctgcgtg cttctgcatc tccggggcca cggcgctgcg
     3721 cttgaccaca cagccgtccg gggcaatgtt gccccacagg atctgcagac cgccggtctc
     3781 agagtagggg ttctcgatgg gacggatggc cttttcgttc aggatatggg cacccttgat
     3841 gttctcgcca agggtcttgc cggtgacggt gggcacgtcc aagtccagca ggcccttctt
     3901 ggccagctct gcctgcaccg ccgggatacc gcccgctgcg tacagatccg gcatgtgggt
     3961 ggggcctgcc ggtgccagat ggcacaggtt gggggtcttg gcgctgatct cgttgaacag
     4021 cttcaggtcg atgggcacac cggcctcgta ggcgatggcc agcaggtgca gcaccgtgtt
     4081 ggtggagcag cccagcgcca tatcacaggt cagtgcgttg cggatggagc gctcgttgat
     4141 gatctggcgc gcggtgatgc ccttgcgcac catctccatc actgccatac cggcgtgctt
     4201 tgccagctgc agacgcttgg agtacacagc cggaatggtg ccgttgccgg gcagggcaat
     4261 gccgatggcc tcgcacaggc agttcatgct gttggcggtg tacataccgg agcagctgcc
     4321 gcagctggga cagcagttgc aggtgcagtc ctccagctgc tcgtcggtga tcataccggc
     4381 cttataggca cccacggcct cgaacatctt ggaaaggctc acttcctcgc cgccgtaagt
     4441 accggccagc atggggccgc cggagcagac cacggcgggc acatccatgc gcaccgctgc
     4501 catcaccatg ccgggcacga tcttatcgca gttgggcacc agcacaaggc cgtccagctg
     4561 gtgtgccatc agcatggtct ccacgctgtc gcagatcagc tcgcgggagg ccaaagagta
     4621 cttcatgccc acatgaccca tagcgatgcc atcgcataca ccgatggcgg ggatcaggat
     4681 gggggtacca ccggccatct gcacaccggc cttgacagcc tcggcgatct tatccagatt
     4741 catgtgtccg ggcacgatct cgctgtaggc gctcaccacg ccgatgaggg ggcgctccag
     4801 ttcctccggg gtgtagccca gcgcataaaa caggctgcgg ttgggcgcgc gctccgagcc
     4861 cttggtcacg ttgtcacttc tcattgcaaa tcctcttttc tgataaagcc ctctccgtca
     4921 cggttgcgcc gtgccacttc tcccgagagg gagaggtttt cgcggaggag ctataaggtt
     4981 cccttttcaa caaaaactcc ccctttcggg ggagctgacc gccgaaaagc ggtctgagag
     5041 ggttctcctc ttacttcttc agccagctca tcatgctgcg cagttcagca cccaccttct
     5101 cgatgggcag ctcagcctcc atacggcgct tggcgaggaa gtgcaccttg cggccgccct
     5161 tggggctcat ctcggtcagg aactcggaag caaaggtgcc gtcctggatt tcggtcagaa
     5221 ccttcttcat ctccttgcgg gtctcctcgg tgatcaggcg cttgccggtg cggtagtcgc
     5281 cgtactcggc agtgttggag atggagtagc gcatcttgga gaagccgccc tcgttgatca
     5341 ggtcaacgat cagcttcatc tcgtggcagg tctcaaagta ggccatctcg ggctcgtaac
     5401 cggcctccac cagcgtatcg aaaccggcgt ggatcagctc ggaaacacca ccgcacagca
     5461 cggcctgctc gccgaacaga tcggtctcgg tctcctcctt gaaggtggtc tgcaggatgc
     5521 ctgcacggcc tgcgccgatg ccggaagcat aagccagtgc gatatccttg gccttaccgg
     5581 tgtagtcctg ctccacgcag atcagagagg ggcagccctc gccctcggtg tacaggcggc
     5641 gcacgatgtg gccggggccc ttgggagcga tcatgatgac gtccacgttc ttgggagcgg
     5701 tgatggtctt gaagtggatg ttgaagccgt gtgcaaaggc cagtgccttg ccctcggtca
     5761 tgtagggagc aacctgggtg ttgtagatat cggcgcacag ctcatcgggc accagcatca
     5821 tgacaacatc gccggccttg gcagcctctt ccacctccat gaccttgaag ttgtcatggg
     5881 tggcagcgaa ctcagaagcc tttgcccagt gagcagaacc cttgcgcagg ccgaccacaa
     5941 cgttgacgcc gctctcagcc agattctcag agtgtgcatg accctggctg ccgaagccga
     6001 tgacagcgac ggtcttgccg tccagcacgc cgaggttgca gtcggaatcg tagtatttct
     6061 tgatagccat aatcgttagt ctccttttac attaactggt tggtttatct tccggtcttg
     6121 tatgctctgt tctatctttc gctcaccctg agcggaaaag caatgtaatt atgcccgtct
     6181 tgcgcccggc gggggcagct ggacggagcg cacctcctgc ggcggcttct ggatatgctg
     6241 gtgcatcccg ccgcgctcca gtgcagtaac gccggtgcgg cactgttcaa ggatgttgta
     6301 accctcgaac attttcaaaa atgcgtccag cttgtccggc cggccgatga gttcaaacac
     6361 catgctgtcc ggggaaagat caatgatctt tgctttgtag atgcaggcga tctcccgcag
     6421 ctctgtgcgg ttgtgcacgt ccgattccac cttgagtagc agcagctccc gctccagcga
     6481 tttttcgctg tccagcacga acacctgccg ggtgacttcc agacgctcgg tctgcagtac
     6541 cagctgctgc aaagcctttt cgtcactggt aatggtcacc gtgatgcggc tgactgccgg
     6601 gtcgttggtg gcggacaccg taaggctgtc gatattgaag ccgcggcggc agaacaggct
     6661 ggacacccgg gccagaacgc cgctctggtt gtccaccagc aggctgatga ccctgcgctg
     6721 atcagattcc atgatgctgt gtcctcctta ttccatgatg atgtcgttga tatcgccgcc
     6781 gccggggatc atgggcagca ccttttcgtc cttgtcaatg atgcactcga tccaggtggg
     6841 gcccttctgc tgcagggcat ctgcaaaggc tttctgaaac tccggcagat tggtgcagcg
     6901 gtagcccttc aggccaaagc cgtctgccag cttgacaaaa tcggtcttgc ggtgggggtc
     6961 ggtctggctg taacgcttgc cgtaaaaggt ggtctgccac tggcgcacca tgcccagcac
     7021 cgagttgtta aagatgaccg tgatgatggg cagctcgtag ctgacggcgg tgcaggcctc
     7081 attcaggttc atgtggaagg agccgtcgcc ggtaaacatc accacacgct gctggcgccc
     7141 cagtgccatc tgggcaccaa tggcagcgcc gtagccaaag cccatggtgc caaggccgcc
     7201 gctggtgata aagccgcggc tcttggtgtg gcgcaggtac tgcgccgccc acatctggtg
     7261 ctgacccaca tcggtaacat acacggcgtc ggggccgcac tggttgcaca cctcgccgat
     7321 gacctgatgg ggcatcagcc gggtggggtc ggacacgggg tggtaatcct gtgcctgcca
     7381 gctctggatc atcttcatcc attccgggtg cttggcgggc ttgatctggg gcagcatggc
     7441 gttcagcaca taggctgcat cgcccacgat ggaaagatcc acgtccacgt tcttgcccag
     7501 ctcgctggcg tcaatgtcga tctgaatgat ggtggcgttt ttggcaaagg tcttggggtt
     7561 cagcgccaca cggtcggaaa agcgggtgcc caccgcgatg agcacatcgc actctgccac
     7621 cgcccggttg gaggtgtagc agccgtgcat ccccagcatg cccagattca tcgggtcgcc
     7681 atagggcaca acgcctgccg ccatcagggt gtaggtagca gggatctccg ccttgtgcag
     7741 cagatcccgc agcggctggc agctggctgc gctgcgcacg ccaccgccaa agtacaccag
     7801 cggacgctgg gcggcgttga tgaggtctgc cgcccagtgc acctgctcct cattataggt
     7861 agtcacggtg cggatgggct ccggctgctt gggggtgaac tcgcacactg ctgcggtcac
     7921 gtccttgggg atatccacca gcaccgggcc cttgcggccg ctctgcgcaa tgcggaaagc
     7981 tgcccgcatg gtatcggcca agtcctctac ccggcgcacc gtgaagttat gctttgtgat
     8041 gggcaccgta atgccctcga tgtacgcttc ctgaaagccg tccctgccaa tgctgctggt
     8101 gggcacgttg ccggtaaagg ccaccatggg caccgagtcc atataggcgg tggcaatgcc
     8161 ggtgaccaga ttggtggcac ccgggccgct ggtagccagc accacgccgg tgcggccggt
     8221 ggcgcgggcg tagccgtccg ctgcatgggc tgcgccctgc tcgtgggcgg taagcacatg
     8281 ggtgatgcgg tcggcattct tatacagctc gtcgtaaagg ttcagcacag cgccgccggg
     8341 gtagccaaaa agagtgtcca ctccctgctc gcacaggacc tctacaaaga tctgagaacc
     8401 attcaactgc atggtgttgc tcctattcct gttccacttc ttatccattc cctcagggag
     8461 agcttttgaa aaagaaaaag cccttgtccc ctgcttcttt caagagacaa agaccttgta
     8521 acatcaagct ctctgcggta ccactctcgt tggcgtgctg tgcacaccct ctcacgggct
     8581 tccaacaaag ccctgcacgg taacggctgc aaccggcgct gcttacaggg gtttgcaccc
     8641 gttgggcagg ctgctccggg atgattttcc gcacgaaacg ctgactgcct tgcaccagac
     8701 ggcagctctc tgaacagtgg ggatcgtgtg gtactttttc ccatctgcgc atttgttgat
     8761 gtaaattata ctataaaccg ggcttttgtc aatcgacaat ttgtaacctg aatcacccca
     8821 aagatgaagc atttttaaca ccccttgcat ccccgcccga accgctgtat acttttgata
     8881 tccgcgtacc tgcgttttgt agggtatgtg ccaatggaga ggaaaaggga tcacctatga
     8941 aactgagaga atggaatgcc catctgcatg ggcttgttgt gttccgcgcc ctgctgaacg
     9001 accctgttgt ggcaaagctt ttagacctga ccgaccgcat ggaggcgggc tgctcctcct
     9061 acggcccggt gtgcgatgcc gtagccgcct ttgaggccgc tttgttcgag tacaccacca
     9121 actggggcag ctacctgagc aatgctgtgc tggaggccga gaccatctgc gtgcggcagg
     9181 ccgccgccgg gcagctggac gcgctgctgc aaagcgcctt ggacagcgag ctgcagtttt
     9241 tgcagcagct gtgcgggctg acgctggacg aactgttcca gaccgcctac tcggagcagg
     9301 cgcagcggcc ggagttggcg ttcctgcccc ggtggcagac ctgtgagctt gaccttgccg
     9361 ccgcctacgc ccagcgcatg agcgaggtgg gcaaaaaggg ctacggtatg tttgcaaagc
     9421 accatgtatt cacggtggag aacggccagc ttgtgccggt aaaatacccc gacccgcagc
     9481 gcctttccga gctgcccggc tacgagaagg agcgggaaaa ggtgattgcc aacacaaagg
     9541 cgctgctggc cgggatgccc gccaacaatg tgctgctgta cggcgatgcc ggtaccggca
     9601 aatccagcgc ggtaaaggcc attgccaacg agtttgcgcc cgagggactg cggctggtag
     9661 aggtaaaaaa gaaccagctg tatcagatcc ccgacctgat ggacaagctg gcggcaaacc
     9721 cgctcaagtt cattttgttc atcgacgatc tgagctttac cgccaacgac gacaactttg
     9781 ccgccttgaa ggccatcttg gagggcagcg taggcggacg cgctcagaac attgcggtgt
     9841 acgccacctc caaccgccgc cacctcatca aggaaaccct ctcggaccgc accggcgacg
     9901 acatccatga agccgacacc cggcaggagt tgatgagcct ttccgcccgg tttggcctga
     9961 cggtcacctt ccagcggccg gagaaggccc ggttcgagac cattctggag cagcttgcca
    10021 agcagcacaa catccagatg cccaccgagc agctgctgct caaggccgag gccttcgctc
    10081 tgcgtgccgg cggccgcagc ccccgggtgg ccaagcaatt catcgagcaa tgcgaggccg
    10141 gggtgcagaa gtaaacgcac cagttttaaa cgttatcaaa aagcgggaca ccaaagcatc
    10201 cgcagatgct ccggtgtccc gcttttctta tctttattcg ctcagtcccg cacggcgatg
    10261 cactcgatct ccagctttgc gcccttgggg atggctgcca cctgcacgca gctgcgggct
    10321 gggaacggct cggcaaaggc cttggcgtac tctgcgttca ctgcagcaaa atcgttgatg
    10381 tcggccagaa agatcaccgt cttgaccacg ttgttcatgg aaagccccgc ctcggccaga
    10441 atcgccttca ggttggcaag gctctgtgcg gcctgctgct ccacggtatc agccatggtg
    10501 ccggtggctg ggtctaccgg gagctgaccg gaaacaaaca ccatgttgcc cagatccagt
    10561 gcctgactgt aaggaccgat ggcggcaggt gcgttggcgg tagatacgac tttcatagta
    10621 tattttctcc tttatattac attatgttta gaacaaattt gcttttttct tcggatagag
    10681 ccggatgagg gggtaatttc ctgtaagctg ctgcttgcct gcgccctcat ccgtctgctc
    10741 actacgttcg catccacctt cccccgtccg ggggaaggct ttcactcttg caaaacgatg
    10801 aagtttacac ccgctcgctg accagctgga agccggcctt ggtcagctcg gtgcggatct
    10861 gctcgatctg gtcggcatcg cgggtctcca gcgtcagctt gaggaagcag ctggagatgg
    10921 gcatattggg gtcggagccg tcatgctgca ccgacaccac attgctgccg cagcgggata
    10981 ccacctcggc cacctttttc aactggccgg gcttgtcctc cagcgcgatg gtcaggtttg
    11041 ccttgcggcc gctcatcaca agaccgcggg tgatgacgcg gttcaggatg ttcacatcaa
    11101 tgttgccgcc ggagatgacg caggccacct ttttgccctc caccggcagc ttgtggaaca
    11161 gcactgccgc caccggcaca gcacctgcac cctcagccac cagcttctgg ttctccatca
    11221 gggagagaat ggccgccgcc gtctcgtcct cggtcacggt aacgatatcg tccacatact
    11281 gctcgcatag ctgataggtc agctcgcccg gggtcttgac ctgaataccg tccgcaaagg
    11341 tggaagcaga tttcagggtc tggtacttgt gctcgtgcag gctgcggtac atactggggg
    11401 caccctcggc ctgtacgccg tacaccttga cctccgggcg cagggtcttg atggcaaagg
    11461 caataccgga aatcagtccg ccgccgccca ccggcaccac cacagcatcc acatccggca
    11521 gctggtcaag gatctccaag ccgatggtac cctgcccggc gatgacctgc tcgtcatcgt
    11581 aggggtggat aaaggtcatg tcgtactcct tttgcagctg cacggccttg tcgtgggctt
    11641 cgtcgtaggt gccgggcaca aggcagacct ccgcgcccag atttttggtg ttttccacct
    11701 tcatcagggg tgcgccgtcc ggcatacaga cgatgctgcg gatgccgcgc cgggtagcgg
    11761 ccagcgccac gccctgcgca tggttgcccg cagagcaggc aatcacgccc ttggcgctct
    11821 cctcctcaga aagctggctg attttatagt aagcgccccg caccttaaag ctgccggtgg
    11881 cctgcaggtt ctcggtctta aggtacagct ggcagtcctt ggacagcttg ggggcttcga
    11941 tgaggtcggt cttgcgcgct acatccttca gcacaaaggc ggcgtggtag atcttatcca
    12001 gagtcagcat gacagatact tcctttattt ttcgtgatgt catccagtat aagttacaaa
    12061 aattgttttg tcaaatgaat ttcattcacg acaaaagacg taaaaaagag aaagacaatg
    12121 gtaaaaccac tgcctttctc tttttattct cattatcgcc cacggccacc gccgccgcca
    12181 tggctggaac caccgcccat gccaccgaag ccgccgccaa agctaccgcc gccgaaaccg
    12241 ccgcgcccgg caccgccccc gaaggagccg ctgcccatgc cgccaaagcc gccgtagaag
    12301 ccgcccggcg ggggcgggtt atgcgggccg cgccgccgtc cacggggagg ccggggcccg
    12361 ccgaagcacc acagccagcc gcaggggctg gcaaaaacat aggccatcga ccggataatg
    12421 acgataagca gcacaacgct gaccacaagg gtcaggatgt cggtcagagt gctgccgccg
    12481 ctgctctgcc cgccctgata gccgggctgc acggtgccgc cgttctcata gcttccattg
    12541 tccagattta cgccataaat gctcgcaatg gtgtcggcca cattatttgc acaggtgatt
    12601 accgcatcgc tataatcacg gtttgcaaaa tcactttcca tggtctgggc gatggcgctg
    12661 gcctgctttg ccagcgtggt gttgcggaag ccatcgccgt aggtcaggta gtagtcgccg
    12721 tccgcgtact gcgccgactc catcaccagc aggatcagaa caccattatt gttcgtggca
    12781 ttgccgattc cccaagcgtt aaatgcttct gtggcataat cttccgtaga aagattacct
    12841 gtgtactgca cagtcaaaac accaatttgt gcgcctttac agttcgtctc caattttgca
    12901 ttcaattctt caatcgtctg cgttacttgg ctattcagcg cattggcatc gtccaccacg
    12961 cactgatcct tgggcaggct gggcagctgg gcggcaaagg ccgccgggca cagcactgcc
    13021 gcactgacca ccacggccag caccagtgcg ctgatgcgtt ttgcaaagtt tttcatgcga
    13081 agggctcaac ctccttcacg ccggacaaag cgcccagcac actggccggg aagccgccga
    13141 cttcattctg atattcatac accgccgtat tgtactgcaa ggtaccaatg atggtggccg
    13201 cactgttgaa ttggccgtac tgcccctgca ccgcgcccat cttcatgggg tcatcggcct
    13261 gctcctgcaa ctttgcatac agctggtcga tggcagcgcc cagtgcctga tcggcctgat
    13321 acagcgcgtg catcgcgctg ccctgataat agggcagcga ggtcagcgac tggcttttac
    13381 cgccgttctg caccgcctgc agacaagcgg agaaatcgtt cagcgccgtc tgtgcagcca
    13441 gcacctcggc gctgtctgcg ccaagggtgt tggaggcagt ggtcagaata ttcgccgccg
    13501 tattctcccg ggtggtcagc tcctcgctca ggttataacc gttgtcggcg gcgacccctg
    13561 cggtgaacca ctgacgggca gtgttgtact tgccgcgcag cttggcgctg ccaaagccga
    13621 aaaaagcggc cagcatcacc accacgctca aggccagcgc cgccgcccgg gtggaaaacg
    13681 ctgcgggcag ctttgcttcc agtgcggcca gcttctgctg gcggggcgtc agcgttacga
    13741 cctgctccgg ctttgctttt tcgcggtagc tgcccgcgtc aaagccgccg ggagcggttt
    13801 gtttgttctg agaaaaatca gcgtttgcca tttcagctcc ggatctccat cattttggtt
    13861 ttcagttcgt cctcgatgcg ggtcagctcc tgctcggcgg cggcgcgctt tgcgcggccc
    13921 tcgctctgga tcttgttcag ttcgtccagc gtctcgatca ggctcttgtt ggtctgctgc
    13981 agcgtctcga tatccacgat gccgcgctgg ctctccttgg cagtctcaat ggtgcccagc
    14041 ttcagcgcct cggcgttctt cttcagcagg tcgttggtca tgttggtcac ggcgcgctct
    14101 gcctgcatgg cctgctggct gtgtgccagc cccagtgcca gcaccatctg gttcttccac
    14161 agagggatgg tgttcacgat ggtagactgg atcttttctg ccatcatggt gttgttgttc
    14221 tgcagcagac ggatctgggg gcccatctgc aagctgatgt tgcgggtcag ttccagatca
    14281 tacagctttt tctcaaagcg ctcgcactgg tcggcaaggt cgcgggcggc ctgtgcatcc
    14341 tccggcagac cggagacctt ggccttatcc atagcctgct gcagttcgtt ggcacgcaca
    14401 tcggccagct ttttcttgcc ggcaaggata tacatgctca gctccttgaa gtaggccatg
    14461 ttcagctcgt acatcttgtc cagcatggcg atgtccttga gcagctgcac ctgatgggct
    14521 tccagcatgg actggatctt ttccacgttg gtctcggtct tgtcgtactt ggtcttgagg
    14581 gcatccagct ggctggtctt tttcttgaag aagcccataa tgcccttctg ctgctcctcg
    14641 ttggcatcaa agctcttcag ctcgccaatg aggttggtga tcatatcgcc cacctcgccc
    14701 agatccttgg tggacacctt ggagagggct gcttcggaga aatcgccgat cttcttctgg
    14761 caggcagagc cgtactgcag cacctgctgg ctgttggtga tatcgatctt ctgggcaaac
    14821 tgatccacca tggcctgctc ctcgggggtc aggttcacct gtgcaaataa tgtggccgac
    14881 accattgcga gcatttatgg cgtaaatctg gacaatggaa gctatgagaa cggcggcacc
    14941 gtgc
//
