LOCUS       gnlProkkaNNFGKLCP_4    13572 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NNFGKLCP_4.
ACCESSION   gnlProkkaNNFGKLCP_4
VERSION     gnlProkkaNNFGKLCP_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 12:05:40
            Original ID  :: gnl|Prokka|NNFGKLCP_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13572
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13572
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3221:3572]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3222..3572
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13572
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13572
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             231..1742
                     /locus_tag="ctg4_1"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYLT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             1815..2882
                     /locus_tag="ctg4_2"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSAGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             2919..3203
                     /locus_tag="ctg4_3"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(3222..3572)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_4"
                     /sec_met_domain="PqqD_RRE (E-value: 1.4e-10, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(3670..5058)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 91.6; E-value: 6.9e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_5"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSMDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(5307..5702)
                     /locus_tag="ctg4_6"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPAAETPAPAAE"
     CDS             complement(5709..6482)
                     /locus_tag="ctg4_7"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(6488..7015)
                     /locus_tag="ctg4_8"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(7002..8243)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg4_9"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(8253..9347)
                     /locus_tag="ctg4_10"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQANFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(9352..10392)
                     /locus_tag="ctg4_11"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             complement(10411..11421)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_12"
                     /sec_met_domain="PF04055 (E-value: 1.8e-17, bitscore: 57.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDDMTNLSLKH
                     RELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGC
                     KMNCKFCMTGKQGYTANLTASQIMNQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALE
                     LLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAF
                     SITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAI
                     PGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
ORIGIN
        1 agaaatcttt ttcaggagaa ataaaagtaa gttcataatg gtgctgcatt gaattatttt
       61 ttggcggagt tattctaaca cttaatagtt caaaaacaga tatttctctg accaaaagat
      121 agaactaatg atgaattaaa agttgcaatt atggttttct tcccacaaca aacgggaaaa
      181 gtcagaagaa tcatgtacat ttgtaatccg aaaactaaaa gaacatcgca atgaaaatat
      241 ttccaagcag cagtatcaag aaattggacg cttataccat tgagaacgaa cctattgcat
      301 caatcgatct gatggaacgt gcagcaaccg tattaacaaa agccatcaca gacagatgga
      361 atacggaaac gccggtcact atctttgccg gaccggggaa taatggcgga gacgctctcg
      421 ccgtagcccg catgatggct gaaaaaggat ataaaatcga ggtatttctc ttcaacacga
      481 aaggagaact ttcacccgac tgccagacca ataaagaact ggtagaaatg atggaagaag
      541 taaaattcca cgagatcagt acccaattcg tacctcccgc cctgacgccc gaccatctgg
      601 taatcgacgg attattcggt tcaggcctga acaaaccgtt gagcggcgga ttcgctgccg
      661 tagtgaaata catcaattcc tcccctgcca tggtagtagc catcgacatt ccttccggac
      721 tgatgggaga agaaaacaca ttcaacgtaa aagctaatat tatccgtgcc gacgtaactt
      781 tcagtcttca actgccgaag ctcgcctttc ttttcgcaga gaacacggaa tttgtcggag
      841 aatgggaagt gctggatatc caattgagcg aagacggtat tgaagaaatg gagactaact
      901 acgaaatgtt ggaaatagag caaatccgtt cactcatcaa gccacgcaaa cagtttgccc
      961 acaagggaaa cttcggccat gcactattga ttgccggttc aaaaggaatg gcaggagcct
     1021 ctgttctcgc tgcccgcgcc tgcctccgtt cgggagtagg gttgctgact gtccatgcgc
     1081 caatgtgcaa caacgacatc ttgcaaacct ccatacccga agcaatcgta gaaaccgaca
     1141 tcaacgaaac ctgttttgcc gtacctaccg acacggacga ctatcaagca gtcggcatcg
     1201 gtccgggact gggacgaaac gaggaaacgg aagctgcctt gttggaacaa ctggaacact
     1261 gccagactcc tgttgtggtg gatgccgacg cacttaatat cctcgccaac caccgtcatg
     1321 cacttaccca cctgccgaag ggttccatcc tcaccccgca tccgaaagaa ctggaacgtc
     1381 tgaccggcaa atgccaggac tcttacgaac gtctgatgaa ggcttgcgaa ttggctcgtg
     1441 ccgcccatgt tcacattatt ttaaaaggag cctactccgc catcatcacc ccagaaggta
     1501 aatgcttctt caacccaacc ggaaatccgg gaatggcaac cggaggtagc ggtgacgtac
     1561 tgaccggagt aatcctggca ctgcttgccc aaggttacct caccgaggaa gccgctaaaa
     1621 tcggcactta cattcacgga ttggcgggcg atgtcgctca aaagaagcaa ggaatgatcg
     1681 gaatgatcgc aagcgatatt atcacctgtc tgccgacagc atggcgactt gtaagcgaat
     1741 aaaagttaag aacttaccct tttttcaata acttcattaa ctttgttttc aaaaccagtt
     1801 aaaaagaacc gaatatgaaa aagttgatta tagcagcagg actacttatg acaacgtccg
     1861 cctatgcaca aaccgaagta ctgacagggg ttacccgagg aaaagactat ggagtggttt
     1921 acagtcttcc caaaacccaa atagaacttg aaataaaagc caacaaagtc aactatactc
     1981 cgggagaatt cagcaaatat gctgatcgtt acctacgact gaccaacgtc tccgccgacc
     2041 ctgaagagta ctgggaactg gctagcgtaa aagtgaaatc cgtaggtgtg cccaacagcg
     2101 aaactacgta tttcgtaaaa ttgaaggata agacagtagc accgctcatg gaactgacag
     2161 aggatggcat tgtgaaaacg atcaatgttc cttacagcaa tagcagtgca ggcaaaaaag
     2221 ctgctcccgc ccccgcagtc ctccaaaaga aagcgaatcc tcgcgaattc ctgaccgaag
     2281 agattctgat ggctagttct accgccaaga tggccgagct ggtggctaaa gaaatctata
     2341 acatccgcga aagcaaaaat gccttattgc gcggacaagc tgataatatg ccttcagatg
     2401 gggcacagct taagattatg ctcgacaatc tgaatgcaca ggaagaagcc atgacacaaa
     2461 tgttctccgg cacctgcaac aaagaagaga gaacattcac tgtccgcctt acccctgaca
     2521 aggaattcaa caatgaagtt gccttccgct tctcgaagaa gttaggtgta gttgccaaca
     2581 atgatttggc aggaactccg ttttatatca gtctgaaaga cctgaaatcg gtcaagatac
     2641 cacaggaaga cggtaagaag aagaaagatt tggatggaat cgcctacaac gtacccggac
     2701 aagctatggt tacactgacc gacggtaaaa agaaacttta cgaaggtgag cttcctatta
     2761 cccaattcgg tgtgatagaa tatctggctc cggttttgtt caacaagaat tctaccatca
     2821 aagtttattt tgatccgaat acgggaggat tgctcaaagt ggacagagaa gaagggaaat
     2881 agaaaaacga ggaagtgaac ttctaaaaaa caaagaatat ggttggtgaa ggacatgcat
     2941 tcgacatgat acgccgaata aaagagggac gggaagcttc ccgcctacgt cgtgaacgtg
     3001 ctaacgataa gttgaagcat ctaaaccgtg caaacgaacc ttatccacta cccaacacca
     3061 cccccgaaga aatggaacgt atcatccacg actcggagaa aaagaaagag aaagacagca
     3121 attattttgt ttggggaacg cttattatca tgggagtcct gatagcaatt gccgtcatac
     3181 tttgggctgt atttatcaaa taaataataa taagttccta tttatacgac tggtatcacc
     3241 agttttataa atccatcttt ctgcatttga gaaagataag ccgatacacg cgactcgtag
     3301 ccctcttcat tttgaaagtg gtctgcgagt ttttctataa tctcacgaac attgcgtttt
     3361 ccatctatca gttcccatac agccgtaccg tgttcttcca atttcacatg aagttctttc
     3421 gacattcctt tcggcacaag gaagcgttgc atccacggat atttaaaacg gggaaaggag
     3481 agcacaattg tctccccttc cctttctgct gtaatatgtt cactgcgaca gggaatgacc
     3541 tctaacaggt tgattttctc tttggcagcc atacttctta ttttttattt cagagtattc
     3601 atactgatac tcttctgttt acaccttgat acaaaattcc tttgtcactt taggtattga
     3661 atttcctagt tacttttgga tattcgcctc ttccagaccg tatcccttct tcttgttctc
     3721 tgcctttaac atcaaagcca caatcagagc aagcacacca aagagagcaa aaatagccat
     3781 cggcaacgtg tagtcataag tctgtgcacc gtctactacc ggacctttgc aataagtatt
     3841 caacacccat ccgatcaaca aaggaacacc catcaatccc cagttctgta cccagaaaat
     3901 caatgcgtat gcagtaccca actgtttttc cggaataatc ttcggaacag acggccacat
     3961 agctgaaggc accaacgaga aggcaaaccc caatataatc atgatgatag tagcaaacca
     4021 ccatatattc agtataggca gagcaaacat cgtatgcaca aaaataagca tcactgatcc
     4081 gattatcatc aatgtggctc ccttaccaat acggtcataa agcgagccga acaacggagt
     4141 cagaataatc gcaccaatcg gcaacaatcc gggaatcgtt cccgccaact tcggatctac
     4201 attatacttc tgcaccatca agtcggcagc atacttgata aaggggaata cagccgagta
     4261 gaacaataca catagtaatg caatcagcca gaatccttta ttggtaatga tatacacaat
     4321 atctttcata cggaacggct cttccggttc caatccctct gcatccaaag aagcatccaa
     4381 cttcttatca tagaaagtat aaaggaagaa agcaatcgta cccacgcaca acataatcag
     4441 acaaaacaga atcggagcag gaatattggt atggaatgtg ccactctcat ccatagatcc
     4501 gaaaaagtcg gccaaaggaa ccgtaagcac cattgccaga gttgttccga tacgtgccgt
     4561 agccatttca agtcccatag ccaacgccat ttccttaccc ttgaaccatt tcacgataat
     4621 cttggaaact gtgataccgg caatttccac acctacaccg aagatagcat accccaatgc
     4681 agccagggtt acctgtgttt tgaatccgaa gagcatggca ccttccggaa aagtagtaga
     4741 aatcgcatag tatttcaatc cacaaccaaa caccatcaat aagcaagctc ccattccggt
     4801 gaaacgaact cccatcttat ccaaaatgat accaccgaag atcagcatca acaggaatac
     4861 attaaaccat ccgtaagcgc ttgtgaagaa accataatca agactgtccc atagtagttc
     4921 tttctcaagc atgggtttta gaggagacat tacgtcggtg aggaaatagc cgcatagcat
     4981 agtaaatgcg actaatgcta gaacactcca tcggagtacg gcggagtcat tcaatttctg
     5041 tttcaaatgt tctgtcattg ttatatttaa aaatagtagt taataatctt atacagccaa
     5101 caaaggtagt taaatctcgt ttgtttctat cacaaagaga ttgtttttac aagaaaaagt
     5161 taagtgcgga ttacactgac cacgcggaag attgaaaatc cgtgtaatct gcgtaatccg
     5221 cacttaaata tcaaagaaat gcagcatccg tctgcacctt cccattaatg gttttacccc
     5281 aaagtcttac ctgacaacgg agtgaattac tctgctgcag gagcaggagt ttcagcagcc
     5341 ggtgccggag tttctgtagc aggtgcattg gtagcaggag cttcagtttg cggcgcagcc
     5401 gtacctgcgg gtaagttata cgggttagtc tgttgttctt tctgtgcctg ttccaacact
     5461 gcgtctttag caacagcaga gcgaggaact acataagcag tagcaatgct cattaccacc
     5521 atgaagatag ctaagcccca tgttgctttt tccagaaaat ctgtagtctt gcgcacgccc
     5581 atgatggcgt tagatgaaga gaaaccagaa gcaagtccgc ctccttttga gttctgaatc
     5641 agcacgatga aacacatcaa caaggctgca ataaccatta agataacgaa taataagtac
     5701 atttttagtt attttgaatt agcgttaata atcaatttct ccaaaaatct gatttggtct
     5761 gcaaagtaag catttttttt tggatatttc aagcttaatt ttttaattat ttcaagagct
     5821 tttgaatatc gttgctgttt aacatagatt tttgccaaag tttccgtaaa acagctgtca
     5881 tcttcctctt cttccttcat cgtttcttct tcggtaagtt cgtccgaaga ggttggcgaa
     5941 gatggcattt cttctcttaa aggtttcttg cagaggggag agtcgctctc gctcttttct
     6001 ataaagtcgt caatcagttc gtagcctttg agtttgggcg tttcttcggc cgactgttcc
     6061 gtggccggag tctcctccaa aagataagag gtgtaatcca tcgaatagtc gaagctggtg
     6121 cgggcagtca cctcttcggg tactgtggac aagaaagcgt cgatcaatgc taatgtgcgg
     6181 tctacggacg gttcgtcttt caacacctcc gtgagaggta ctcccttttt ccgtgcctgc
     6241 acatcatagc ggtcaccttc aatcaaccgg aacaactgcc gtctgtctgc aatgtaaaga
     6301 actgctttcc gcagttctcc accgaaacta atatcatgga gaatatacag attcttcaga
     6361 tacagcagac gaagtgactg aaaatacgga tacctcgcaa gaagattgcg cagttcgtac
     6421 aaagtatccc tattcagcgt ctcgggatgc tgaatccatt gttgaaagtt aacagaagtc
     6481 atttatatta ccagtttgct acagttgcat taaaaatttg gtcggtgatc tctttagaca
     6541 tttcagcaat caatccgtcc tgtacggcag tcagcaactg gctagagtcg taggtacgga
     6601 acgcagaaaa ctgttgttca aagtcttcgg catgattggt gttgttgaca aaacgtacat
     6661 tgacggtaat agtcaacttc gtctccgaag aataaccgtc ggcagatact gcctggttgt
     6721 actgattgta acctgtgatt tctccgtcaa tctgcaagtc ggcattctga ttcggcttga
     6781 gcagttgcag acgggtctgc cggatgaaga tatctttcag gtcctcattg aatttggttg
     6841 ccaacggagc atatacatac tccgacttga tcgggaagtc ggctatcgaa atggtcttta
     6901 ccttatcata attgatagac gatccgttaa acttatagga aacagtgcac gcaatgacta
     6961 ccaacggcaa gccgaacagt aacaaagggc gtattatttt cttaatccaa ttcatattct
     7021 tttatttttc tataaagtgt acgctcggaa atattcaagt ccttggccgc actcttccgc
     7081 tttccatgat gcctctcaag tgctttgcgt atcatttctt tctccacttc gtccagtgac
     7141 aaaggagatt cttctacata ttcttccgtg tcttgtatgt catcatcatc cttgcaaacc
     7201 gtgggctgca tggtgtgaat gatagcaggt accgaaggtt gatgcgccgt cactaccgga
     7261 gtagtaacca ccgttcccat ttgtcctacc tgccccacct gtccggcacg ttccgccatc
     7321 aggttgtgca ccatcttctt cagctccgcc acttcctggc gcatatcgaa cagaacagaa
     7381 taaagaatct cccgttcgct ctcaaagcct ttactctcac gcgttcccat cagcgcggga
     7441 agacgttgcg tattttgtgc gggaagataa ttctgcaaga tagcagcaga gatctcccta
     7501 ttggtttcaa tgatagatat ttgctcggtg atgttcttca actgacgcac gtttccgggc
     7561 cacgggtaag ctaacaactc tttcttcgca tcctccgtca actgaatagc aggcatccga
     7621 tatttctctg caaagtctgc ggaaaactta cggaacaaca aaagtacatc gtcaccacgt
     7681 tcacgcaaag gcggtatttg gataggcacc gtattcaacc ggtaatataa atcttcacgg
     7741 aaacgtcctt ctgcaatcgc ttgtgtcaga ttgacgttgg tagccgccac cacacgcaca
     7801 tccgtttttt gtactttgga cgaacctact ttcataaact cgccactctc cagtacacgg
     7861 agcaaacgtg cctgggtaga catcggcaac tcccctactt catcaagaaa aatagtacca
     7921 ccgtcagctt cgccaaagta ccctttccgt tcgccaatcg caccggtaaa cgcacctttc
     7981 tcatgtccga acagttcgga atcaatcgta ccttccggaa tagcgccaca gttgacagca
     8041 atatactgtc cgtgcttcct ccggctatat tgatgaataa tctgcggaaa actttctttt
     8101 ccgactccac tttctccggt aatcagcaca gacaaatcgg taggagctac ctgaatggca
     8161 acatctatgg cgcgcgacaa tgcttcagta tttccaataa taccgaaacg ctgtttcact
     8221 tgttgtatct ctgctctcgt catcactcgt ttttaatctt cgtctactgt atccagcttc
     8281 agtttatcac tatcgtcacg tttctcgtaa tactgtttac gcaacggatt ggcacgagcc
     8341 actttttccc gctgacgatt acggaacacg tcgatggcaa catagattgc ctggcggaaa
     8401 gaatcttcac aagccactcc cttacctgca atatcgtatg ccgttccatg agccggagaa
     8461 gtacgtacta ccggcagtcc tgccgtatag ttcaccccgt cttccatagc caaggcctta
     8521 aacggagcca gcccttgatc gtgatacatc gccaggatac cgtcaaaatg agtataattg
     8581 cctgaaccca taaagccgtc ggccgcataa ggaccgtagc aaaggattcc tttctcttcc
     8641 atttctttca tggcagggat aatcacttcc tgctcttcca ttcccaacaa accaccgtct
     8701 ccggcatgag gattgagaga aagcaccgca atacgcggag cgccgatacc aaaatcctgt
     8761 ttcagacaac gatggaatat catcagtttc tcctgaatca attctttggt aatcgtagtc
     8821 gcgatctctc tgacagggat atgtgtcgtc accaaagcca cccggaagtc attcttcatc
     8881 aaaatcatca atgacttatc accattaccc agacgttctt cgatatattc cgtatgtccg
     8941 gggaaggaga actcttccga ctgaatcgta tgtttgttga tcggagctgt tacgataacg
     9001 tctatcaacc cttcgcgata ttcttcgatg gcacgttcca aagcccccaa cgcagcttta
     9061 ccggcttcgg gatcgggttt ggaaaattcc actttcacct catcatccgt acagttcacc
     9121 acgctcaaac ggttgtaccc cgcctcggta gcagagttga caatgctaaa attggcctgt
     9181 atatccagcg ctttgcgatg ataagccgct actttcggtg agccataaat gatcggagta
     9241 catagttcca acatcgtagg gtcggaaaat gtcttaagaa tcacctcata gcccaccccg
     9301 ttaatatctc cttgggtgat acctatcctt atcttgttat cttccatgtt tttatttatt
     9361 agtttgttcc gcttccttag atgcttctcc caatggaatc tgcttctgct gaacttcatt
     9421 cggaagtttc agtgtataca gagatgcttc catctggcgt accaggttgc gtttcatttt
     9481 atcaggtgaa taaacaaata tttctgctgt aataattcgt tggtttttct cgtccaaacg
     9541 agtgtgagag acatacggac cacccataaa gtcgcccttc atacgccaca ggccacgtgc
     9601 ttccattgtg tagctgttct gcacattgat cggacggaca tcggtcagca aactatcggt
     9661 cgacatataa acgccttcct tgaatccggg gatattggct ttcatcacag agtcacgttt
     9721 gtgcacaaaa tattctttgg taaacgtatc cttgtcagtg tacggataag agtacatcac
     9781 aaagttacgg tcggcagtac ctgtgttggt agaagcccag aagaaatcat ccccggtctt
     9841 tgaattagcc agttcggcat ccacccagat gtcgcatccg aacaaactgt ccactttctg
     9901 cgaaatgaag ttactgtgtt tcccttccag gaacgtaatc tgacggttca tttccgcacg
     9961 ggtaaagaag tcgacaatcg tctttttgtt ctcttccaca aacttctcga actcttcttc
    10021 gttcggagcc tggatagtca atatcatctg cggattggca tacacgtcct tcgcatattt
    10081 gaacgaggct ttcgtatata tatcctgtat atctacaata ataatgttac gtatcaactt
    10141 cagcgtagaa tcataatctt tcggtgaagt atacataatc cggaaagaag gttccgactg
    10201 cggcaaaccg ggcatatcag catcgagcgc atcatgtaaa gcccttccgg cagcacgatc
    10261 ccaaacaccg tgatctacta caaccaaaag ctcgtaagca cgaccactag aggtgtgatt
    10321 tcctttcaga ccacaagatg caacgacaaa ggctaccaaa gcgatgcata aaataaaaga
    10381 gtactttttc atgatgttcg gttttatata ttaactttca ttatttttct cctgtttcgc
    10441 tgtcgacagc ataccgcaag cggcaaaaat atcttcgcct ctggatgaac ggatagtggt
    10501 gaaaagtccg tgtgacgtca gataatcacg aaaacgggtc atcgtatcca tgtccgcccc
    10561 ctcaaggtct acccccggta tggcatgaaa acgaatcaga ttcaccctgc aatccagccc
    10621 gcgaagaagt ttcagcaact ctttggcata gacctgcgaa tcattgagcc ctttaaaaac
    10681 aatatattca aacgaaagtc gacgttgttt actaaaatca tagtttttta acagttccac
    10741 catttcggtg attgaaaacg ccttttccgc cggcattaat tcagcacgct gaacggtcag
    10801 cggagagtga aggctgatgg caaggtggca gtcattttct tcgataaaac gctgcaatcc
    10861 tttccgtagc ccgacagtag aaagcgtgat acgcttcgga ctccatgcgt aaccgtaggt
    10921 agcggtcagt agttccaatg ccttcaatac ctcatccagg ttatcgagcg gctcgcccat
    10981 tcccatcatt acgacattag tcagtttgtc ccgttccggc agcgaatgaa tctggttcat
    11041 gatctggctg gcggtcaggt tagccgtata cccctgtttg ccggtcatac agaacttaca
    11101 gttcattttg caacctactt gtgacgacac gcacaacgtt gcccggtcat catccggtat
    11161 ataaaccgac tctacaaaat ggttctcacc cactttataa agatacttca ccgtaccatc
    11221 tacagagcgc atttcatcta ccggagcttc cgctcccacc tcatagttct gcttgagcaa
    11281 ctcccggtgt ttcaatgaca aattagtcat atcatcaatc gaggctacct tcttttcgta
    11341 aagccaggat gcaatctgct tggcagcaaa gccgggcata cccagtcttt ttgtcaatga
    11401 ttgaagctct acaagagtca ttcctaaaag gggatattta gacattcttc tttctgttga
    11461 tagtttatat ctgcaaatgt aaggaaataa agtcgatttc cgtatagcag gaatgtaaaa
    11521 gttaacaaaa aagggaagta tacccaagtt attatttaac aaagctgata tattgaagta
    11581 gcgttcgcgc caattcagag tcctcgccat tccgtttcac ttcgtgacca tacgcctcac
    11641 ggaaacaagc cagcgcatct ttccgttcat aacaatattt gtgtaaaacc cctaagtttt
    11701 gacaagccac aatcgtatct tcattctccc atccctgatg cttctttcgc agttcaaact
    11761 ctttgaagaa agccgctttc gccattggat aatccttctt tttcgtataa gccagtgctt
    11821 tgtagtaata taccagacag gaagaatcgg ggtcaccatc atcatgaata tccagggagg
    11881 ttgctatacg aatcacatta tcataatctt tattcatgta atattgctgc ataatatcac
    11941 atcttaatgc ctcgtaacgg atagtcaatt ctgccaaacg aggcttttcg ctgaaaaaca
    12001 cttcatgcag aagagactca tggaagaata aagtagcggc ctgctcatcg ttacgctcat
    12061 tcattatgcg tttgaattct atgcatagat aatacaactg tttatgacaa gcgactatct
    12121 gctttctatt atctatctgc atagaaatat ccaatgcccg attcatcaga ttccacgctt
    12181 catcgtattg cttaacacaa taaagacatc taccttgcat acgcatgcat ttagccactc
    12241 cacttgacaa tctaccattc aaagattcgt gcattttagc tactttccgg aattgttcgg
    12301 ccgcactctc ttcgtttttc ttataataat cgcaataagc cagcagttcg taaagttcaa
    12361 tgatttctgc catattattc tcgtcagtag aagccgcatg atagccaagc gctctattta
    12421 gataagtcac cgcttcatta tattgcccat tataataaca tgccatcccc aaattcctac
    12481 atgtatcagt aatctggggt accggaatcg gtactatatt ttcctgcatc atcaatgctt
    12541 tcaggaaaca atcacatgcc atttcatatt cttcgtcacg ggcatagcga catccctcgt
    12601 tcattttcag cactgatctg gcaattggcg gtatggcagc tccttccata catttctcac
    12661 tcacaacatt tgctaccttt gtcaggtgaa aagaacgact taagaaagta gctatatcat
    12721 tagcaatgac aggaatcaaa aaagaatcaa cctgaccaaa gtccgattcg gcatagacat
    12781 caggcataaa agaagagtcg tcgctcataa gtgccttcca gcaatcttcc aacaaagaat
    12841 aattcgtacg atacagaatt tcgaagagtt ctacatcaca aatccacttt ctcaagaaat
    12901 tccgctcctg catcttataa ccttgataag taatttccac tttatagcga taagaatcat
    12961 ggtagcagaa ctgtttcata cgatagctat aatcagcaaa agtcagttgg tgcgaaagga
    13021 tatcttcatt gtccagaaaa gaggttatta ttttatgacg acacttatcg atgcacatat
    13081 cgccttgagc gaagcatcgt ttaatcgcct ctaccatttg tgtgtcacaa atacaatatc
    13141 gccctccttt gttggtgagc cagctactca tttccacttt caactgtgac caaagcatct
    13201 gatttatgcc tgccatgctc tttacttcat cttcggtaaa tccttctaaa gtaagtgaaa
    13261 gcatcagaag cgttcttcca atctcttcga aaccataatc agccgacaaa cgccgaagca
    13321 cactgtcata aaattgctca acctcattga gccggcaata tccactcata tattcataga
    13381 gagcatcgta ctgaccgaac gaaaccagct cattgagcaa tacacttaaa cagcgcggtt
    13441 gtttagccag cacccacgaa ccaagaatat cttcctgctg tgcagacaag gtcttggagt
    13501 aagcagacaa atattgtttt gagaactcct tagcatccac ttgtgaaaaa ccattcaact
    13561 ggaaatgaac gt
//
