LOCUS       c00013_gnlPro..        16966 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NNFGKLCP_13.
ACCESSION   c00013_gnlPro..
VERSION     c00013_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 20:32:23
            Original ID  :: gnl|Prokka|NNFGKLCP_13
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16966
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16966
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3993:6966]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3994..6966
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16966
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16966
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             2..130
                     /locus_tag="ctg13_1"
                     /transl_table=11
                     /translation="PNAFVAFNGLRAMGYECIFFRDMKNSLQTTISKKNSLLAVSA"
     CDS             765..1484
                     /locus_tag="ctg13_2"
                     /transl_table=11
                     /translation="MKEDRDLSFLAYCKNEDLKTLVDMLTHDTNGEVRISEQLTNTDAY
                     LYCYPYRLSMMWQEIANELQRFGGNTLANLYRRNGVCYKEILRDVCRKAEVYFNDKTNT
                     KELERSLLEKVCHDTVGQMDEKELRNMAEELNIPVKNPRKYMIIAALQLAIKRGGALSK
                     RIILYVARMISKMLLGHGLAAFGSNILFKTLGKLTGPLGWSITIGWAVYDLASPAYRVT
                     IPCVIQIACMRMQLSNY"
     CDS             1503..2285
                     /locus_tag="ctg13_3"
                     /transl_table=11
                     /translation="MKATDIMHPEDAKAIQMIKSVPGYEKLVRLFMKLGYEMQYRGENL
                     ANMVRVTPHCYPQIYGLFKEVVNKTGIKEPELYIYNDPEMNAYTYGETRTFVALSSSIV
                     EKLTPEELKGIMAHECGHILCKHALYKTMFRTLRDMGAFMGLIHRTLFAPLYLALQYWN
                     RKSELSADRCGMIITSEEIYQSSLVKLASGLKETPGMSRCLIEQGKQYEAFKHSSLWSR
                     IQQEYRCVFYSHPQLCTRAMEVDRWRNSHTYRTLRTAI"
     CDS             2315..2860
                     /locus_tag="ctg13_4"
                     /transl_table=11
                     /translation="MNKAVPFWKKMFFKNNVNKIRQTIISYLKEEGIETELTDGVIIVI
                     FDELHYGIHFDLENDYPKCNIVFGLKSEDYETLELYQKTFIADKVNTDGEHLSVVRAYK
                     DSIEVDTSFFFNDKDMLLSLFYDYFCDIKNTVDEMYACLATKVEENEEMKKRRPIGFTA
                     NITTKKVEEENNMAACKE"
     CDS             3994..6222
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_5"
                     /sec_met_domain="Gly_radical (E-value: 5.2e-46, bitscore:
                     148.6, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1172.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKIFKDGLWSTEINVRDFVSHNITPYYGDASFLEGPTERTKA
                     VWNRCLEALAEERANNGVRSLDNVTVSTITSHKAGYIDKENELIVGLQTDELLKRAIKP
                     FGGINVVSKACHENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRMALYGIDRLIEAKKEDLRNLTGPMTEARIRLREEVAEQIKALKDMK
                     VMGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYMEYELSK
                     GTITESFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESLGGRLNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNLTVLWSPELPEGFKEFCAKVSIDTSSIQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARCNLAKALLLAINGGRCENTGTVMVKNIPVLTSDTL
                     NFEEVMSNYKKVLTEIARVYNEAMNIIHYMHDKYYYEKAQMALVDTNPRINLAYGVAGL
                     SIALDSLSAIKYAKVTARRNDIGLTEGFDIQGEFPCFGNDNDKVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGVAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATEEDRVENLVTMMDGYFTKGAHHLNVNVLN
                     REMLYDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             6238..6966
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 74.2;
                     E-value: 4.3e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_6"
                     /sec_met_domain="Radical_SAM (E-value: 1.2e-28, bitscore:
                     93.5, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIAGKG
                     GTPTPPEEIVRMAMSQRPFFGKRGGVTFSGGEPTFQAKALVPLVRELKEKGIHVCIDSN
                     GGIWNEEVEELFKLTDLVLLDIKEFNPARHQALTGRSNEQTIRTAAWLEENEKPFWLRY
                     VLVPGYSDFEKDIRYLGEALGKYKMVQRVEILPYHTLGVHKYEAMEQEYKLKDVKENTP
                     EQLEKAAEVFKEYFTTVVVN"
     CDS             complement(7042..7488)
                     /locus_tag="ctg13_7"
                     /transl_table=11
                     /translation="MRKISLIVIHCSATRADRDFTAKDVDTAHRFRGFSCWGYHYYIRK
                     SGQIEPMRDEDTVGAHARGFNAISLGVCYEGGLDEDGKAADTRTSRQKEAMHRLVSELL
                     QRYPDVKMVGHRDLSPDTNYNGIVDPWERIKECPCFEVIEEFES"
     CDS             complement(7475..7666)
                     /locus_tag="ctg13_8"
                     /transl_table=11
                     /translation="MITLILDQMKEIVTKILDVIMFLVPFFGKRKRNRIVREVRFNATH
                     KEVCNVKTTEREKDDEKD"
     CDS             complement(7663..8166)
                     /locus_tag="ctg13_9"
                     /transl_table=11
                     /translation="MAMTVTYSVVPRKNPAKKDESAKYYAQAQASGELDFEELCEGITS
                     RSTCTETDVRAAISGILYEAKRALKAGRIVRLGDLGSLQIGLNSEGAVSVKEFSSSLIT
                     AAHIIFRPGKTLADITKILSYQQVTTRAVAQTGGSGNEGEDDDKGSGGGSDGGGSGEAP
                     DPAA"
     CDS             8360..8590
                     /locus_tag="ctg13_10"
                     /transl_table=11
                     /translation="MYYPDQPFLIRTYKKSELAHLYNPNVCLKVALQILRRWIVYNLPL
                     LQELEQEGYRARNRLLSPRQVATIIRYLGEP"
     CDS             8678..10795
                     /locus_tag="ctg13_11"
                     /transl_table=11
                     /translation="MEHFTIFQDFYRVIAEMTEEEIVSAISNGTYQETVEDVRRIFTEQ
                     GEKAANEKKIELPEITFSANYRGGRSNATLVKYLGYIVVDIDHQTQEALARILALAKKC
                     AHTRIAFISPKGMGLKIVVRVCRTDGTLPETIQEIEDFHHAAYHKIASFYAQLCGVEVD
                     TSGQDVSRTCLFSYDPDIYFNPDATAVIVEQPPMFFKSQKKKRASGKKKKTTAPDNNPL
                     TEQVALNYHSSHASLMVTLNYYHNKSEKYVTGNRNNYLHCLACMYNRYGVPQEEAAAFI
                     KSQFTDLPADEMDALIGSAYGHNEEFDTRKLNSTQKRILQIEQHIKENYDTRYNEVLHI
                     MEYRRRKTDTEQPEPFHILDEMMENSIWMEMNELGYSCTVKTIQNLIYSDFSSTYHPIR
                     EYLDSLPEWDGTDYIGILANSVHTSHQKFWVECLERYLVGMCAAATQDDVVNHTVLLLC
                     SEIQNIGKTTFINNLLPPELRAYLSTGLINPNNKDDLAKIAQAMLINLDEFEGMNGREL
                     NIFKDLVTRKVISIRLPYARRSQNFPHTASFAGTCNYQEVLHDTTGNRRFLCFHVNSME
                     FIKINYAQLYAQIKYLLNKPGYQYWFTQSENSRIEENNEDFIFHSPEEELVLTHIRKPE
                     RFEKVHYLTVTEIAELIRERTGYQYSHGTKAQLGKVMSKHGFEFHKGKNGRRYTVFIID
                     TEQVKSNRLYE"
     CDS             complement(10784..11014)
                     /locus_tag="ctg13_12"
                     /transl_table=11
                     /translation="MVGNLKKITVFFKFPTVFLRKKKEKVRVGEGKFLTFVFFLEENRR
                     IEIRNIKMKSCKSTLTNPHLFACEGDEILFI"
     CDS             complement(11032..11334)
                     /locus_tag="ctg13_13"
                     /transl_table=11
                     /translation="MQINNHQIVDYDAVLDAKFGAEGTPERAEAEEKAYAFYTGQIIED
                     ARKKAKITQAELARRIGSDRSYISRVESGQTEPKVSTFYRIMNALGCRIEFSMSL"
     CDS             complement(11300..11662)
                     /locus_tag="ctg13_14"
                     /transl_table=11
                     /translation="LQYGKPQRNLRTYGGYVEAFMETLTEKEQDKIQYGLLLLKTQERL
                     STKFVKFVQDGVFELRTEYNGNIYRVFFIFDDGNIVVLFNGFQKKSQKTPGSEIDKALK
                     IKEEYYADKQSSNSRL"
     CDS             complement(11712..11957)
                     /locus_tag="ctg13_15"
                     /transl_table=11
                     /translation="MSHLTPVIIEYRGNPKQYVSVVLDAINLGRLTYDGVANCEQTFRA
                     LASVVDVISPKNGKTLSVETLVSYEKKKRAGEFEEK"
     CDS             complement(11966..12100)
                     /locus_tag="ctg13_16"
                     /transl_table=11
                     /translation="MENSLNDELLCSLKDELREVTAQINVHSEKLMDLLDQKKESSVN"
     CDS             complement(12227..13582)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 151.1; E-value: 1.3e-46)"
                     /gene_kind="transport"
                     /locus_tag="ctg13_17"
                     /sec_met_domain="MFS_1 (E-value: 2.5e-46, bitscore: 151.1,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKQLINFYKVSSPRPCNGEALSSSDARRLKFLKWSTFLSATFGY
                     GMYYVCRLSLNVVKKPIVDEGIFSETELGIIGSVLFFTYAIGKFTNDFLADRSNINRFM
                     TTGLLITALVNLCLGFTNSFILFAILWGISGWFQSMGAASCVVGLSRWFTDKERGSYYG
                     FWSASHNIGEALTFLIIASIVSVLGWRYGFFGAGIVGLIGALIVWKFFHDTPESMGFPS
                     VNVPKQKKEMSETETADFNKAQRQVLLMPAIWILALSSAFMYISRYAINSWGVFYLEAQ
                     KGYSTLDASFIISICPVCGIIGTMFSGVISDKLFGGRRNIPALVFGLMNVIALCLFLLV
                     PGAHFWIDVLAMVLFGLGIGVLICFLGGLMAVDIAPRNASGAALGVVGIASYIGAGLQD
                     VMSGILIEGQKTVQNGVDVYDFTYINWFWIGAALLSVLFALLVWNAKSKEMD"
     CDS             complement(13596..14501)
                     /locus_tag="ctg13_18"
                     /transl_table=11
                     /translation="MLRKINILIALTLLIIGGLEAQNHSDKIIANLQKPASNSVLVVSH
                     RADWRNAPENSLQAIQNCIDMGVDVIEIDLKKTKDGHLILMHDKKIDRTTTGKGYPADY
                     TLEELRQFRLKSGTGHKTAHLIPTLEEVMSLCKGKILVNIDKGYDYFKDVYAVLKETGT
                     VQQCIIKAGLPYEQVKAENGDVLDKVIFMPIVQLHKDGAEAVIDSYQTHMKPAAYELVF
                     DSDSPEILNLIKKVRNTGSNLFINSLWPELCGGHDDDRAVELHQPDESWGWIIGQGAKL
                     IQTDRPALLLEYLREKKLHD"
     CDS             complement(14508..16262)
                     /locus_tag="ctg13_19"
                     /transl_table=11
                     /translation="MIMKKYIFLIVTVVCLFACKDGDEVRQTTSPEASFSIDKEEYTVG
                     DIVYLTDESVKTEGEIVEYFWHFGFEGEGNRATTKDASVLYKRAGTYVIKLTVTDEFGG
                     YATASHTVVIRPTNMPPVTNFSYSPAICKVNEKVQFTDKSVDEDGEIVSYEWDFGNGQT
                     SQEKDPEITFTTTGFVTVKLTATDDRGATNTKQATLYVRDTSISGVTVLWDKTFEVSSS
                     LRSISPAVGDNGDVYVSSNALHLFAYSPSGEQKWMFDLSKDGGAGNQGSSPMVGADGTI
                     YMGASTTDKNISSSLYAIHPDGTQKWRYELGIGTNIPYISPALSRDGNILIGNRGTDGS
                     VHMVDRSSGRQFWRRKSPNGGANGGISVGQNGVIYSALSGANGFARTTQDGVNLSPNLG
                     KGNTAAAVYPAIDAQGNVYVAFSEGVVAAYDNQGNELWRYPASGTMGKIDQGGPAIGAD
                     GTIYVGTKNPNAQVVALTKGGAKKWSYSSVAEIGTTPAIDSDGNIHICDDDGNYIILNA
                     DGTEKYKRQLGSKIWSSPVIADYGIVYVTYEDNGACKLIAIDCGIEGPANSPWAQRGQN
                     AKRNALQK"
ORIGIN
        1 ccctaatgcg tttgtggcat tcaacggttt gcgtgcaatg gggtacgaat gtatcttttt
       61 cagagatatg aagaactcat tgcaaacaac catatcaaag aagaactcat tgttggcggt
      121 atcggcataa tcaagcgaag attacaagat ttcgggattg aatgtgccga aataaactat
      181 ccgcaagtat taaacaagta tctcggaaga aggatttgga aatcaaccat caatgagata
      241 gccaacaccc caaaggtatg gcctgtgttt atcaaatctg ttgaggggaa aagattgtcc
      301 agtaaaatca tcaatagcat tcatgactta gtgggttgtg gatgctgtga tgataattac
      361 gaggtgttat gtagcgatcc cgttaatttt attgcaggag tggagagtat ttgtcaggta
      421 tggaaagata cttgatgtca ggccccataa aggggattgg aaagttcatt atgacccgaa
      481 gtgattgaaa atgcaataaa agactatgca actgcacccg atgcgtatgg cattgatttc
      541 ggagttacct caaagggcga aacactactg gttgaagtaa acgaaggata cgcccttgga
      601 tgttacggtc tatttccaca tctatatgct aagtctctta tcacccgatg gactgaattg
      661 acagatacat tggataaata ttggtatatt tagcttccct cggacacctt ttgtctccct
      721 ccctatcttc ctttgcaata cgaaacaata aaaaacgtag tattatgaaa gaagataggg
      781 atttgtcatt cttggcatac tgcaagaatg aagacttaaa aacactggtt gatatgctga
      841 cacacgacac taacggagaa gtccgcatat cagagcaact tacaaatacg gatgcttacc
      901 tctactgtta tccgtaccga ctgagtatga tgtggcaaga aatagccaac gaattgcaac
      961 gctttggcgg aaacaccctt gccaacctgt accgaagaaa cggagtatgc tataaagaga
     1021 tactgcgcga tgtctgccga aaagcagaag tttacttcaa tgacaagacc aatacaaaag
     1081 aattggaaag gtcacttttg gaaaaagtct gccatgacac cgtgggacag atggatgaga
     1141 aagaactacg caatatggct gaagaactga acattccagt aaagaatcct agaaaatata
     1201 tgattatagc tgcgttgcaa ctcgccatca aacgtggtgg ggctttatct aaaagaataa
     1261 ttctctatgt ggcgcgaatg atttccaaaa tgttattggg gcatgggtta gcggcttttg
     1321 ggagtaatat tctcttcaag actttaggga aattgactgg tcctttaggt tggagtatca
     1381 ctatcgggtg ggcagtctat gatttggctt ccccggccta tcgggtaact ataccttgtg
     1441 tgatacaaat agcgtgtatg cgtatgcaat tgtcaaacta ctaagaaagg agaagcagaa
     1501 ttatgaaagc aacagacatc atgcatcccg aagatgcaaa agccattcag atgataaaga
     1561 gcgtacctgg ctacgagaaa cttgtacggt tgtttatgaa attaggatat gagatgcagt
     1621 acagaggaga aaaccttgcc aatatggtac gggttacccc acattgctat ccacaaatat
     1681 atggactgtt caaggaagtc gtaaataaga cgggtatcaa ggaaccggaa ctttatatct
     1741 ataacgaccc cgaaatgaat gcctatacat acggtgaaac ccgtacattc gtagccctct
     1801 ccagcagtat cgtagaaaaa ctgacacccg aggaactaaa aggcattatg gcacacgaat
     1861 gcggtcatat cttgtgcaag catgctttat ataaaaccat gttcagaaca ttacgggata
     1921 tgggtgcttt catgggactg attcatcgta ccctgtttgc tcctctttat cttgccttgc
     1981 aatattggaa tcggaaaagc gaactttcgg cagaccgttg tggaatgatt attactagtg
     2041 aggagatata tcaatcgtcc ttggtcaaat tggcttccgg attgaaggaa acacctggaa
     2101 tgtcgcgctg cctgatagag caaggaaaac aatacgaagc atttaagcat tcctcgctat
     2161 ggagccgaat ccaacaagag tatcgctgtg tattctactc gcatccgcag ttgtgtaccc
     2221 gtgctatgga agtagataga tggagaaatt cacacacata tagaactttg agaaccgcaa
     2281 tataattgtt acacctctat aaaaacgtaa ccttatgaat aaagcagtac ccttttggaa
     2341 aaaaatgttc ttcaagaaca atgtaaacaa aatccgccag acaatcataa gctatctgaa
     2401 agaagaaggt atagaaacag aattgacgga tggagtaatt attgtcatat ttgacgaact
     2461 gcattatggt atccactttg atttggagaa tgactaccct aagtgcaaca tcgtgttcgg
     2521 gctgaaaagc gaggattacg aaacattgga actgtatcaa aagaccttta ttgccgacaa
     2581 ggttaataca gacggagaac acctttccgt agtaagagct tataaagatt cgattgaagt
     2641 ggatacatct ttcttcttca atgataaaga tatgctactt tccctcttct acgactattt
     2701 ctgcgacatt aaaaacacag tggatgaaat gtatgcttgc cttgccacaa aagtagaaga
     2761 aaacgaagaa atgaaaaaaa gacgtcccat aggttttaca gcaaacatca ccactaagaa
     2821 ggttgaagaa gaaaacaata tggcagcttg caaggaatag acaaagacga cctttttata
     2881 accactctaa tcagtggagt gataatatgc ttaccactta ttgccgtata ttgcatagca
     2941 gaatggattt ataatcaaac accatggcag aaaaagaaaa agctaaagat gaatgcagaa
     3001 ataaatgagt tagaaaccgt ttagggctta taggaagaac tgaaaaggct ttgaattacg
     3061 acccttactt catgaaaaag aatagcagca gggaggaata cctgaatgat ttaagaaaaa
     3121 agataacaga gaactataaa agtccagacc tcatacttgc cattgaagaa gttatgtcgg
     3181 gcgagatatg tcttccatgc tattcaggta actattccgc cttagtatta gcacataccg
     3241 accattacga gatgccccat aaacctttgt attgtctcgg atttatagca gaaccaagag
     3301 cagacaaata tttcagctct ttttatcgct tgattgattg gatgatgaat actataggcc
     3361 agttgaatac tctatctaaa tgtggaagac ataaagatca ctttatctga aaaatccctg
     3421 gaaaatttta aaaatatgaa gtctgcttaa cgaataagag aataaaacaa tttgtaaatg
     3481 aatttaaaga gaaatacgaa aagcaataaa acgaaaaaca atatggctat aagaattata
     3541 caaatccccc actggacttc tttttaaatt caaaaaggct taaataatac aaaaacaccc
     3601 aactttacat ttttgggtgt aaaactgggt gtttgtttta taatttgctg attttcagca
     3661 tttattgcgg agagacaggg attcgaaccc cgggtacctc gcagtacaac ggttttcaag
     3721 accgccgcaa tcgaccactc tgccacctct ccaaaacttc tttatcagaa gtgcttttcg
     3781 ttaaaagcgg tgcaaaggta cgaatatatt ttaaacttac aagagttttc acaaaaaaaa
     3841 atcacgaaca tcatttccaa agaatagcaa tatctaggta ttttatgttg aaaagcataa
     3901 aatagagcat atttatgctg attatatgaa aaaacgttgt aactttgtgc gctctaaaga
     3961 aaaggataac tacaacctct aattttatca tttatggaat taaataagat ctttaaagac
     4021 ggtctttgga gcacagaaat caacgtaaga gatttcgtta gtcacaacat cactccgtat
     4081 tatggagatg cttctttcct cgaaggacct accgaacgca caaaagctgt atggaaccgc
     4141 tgcctcgaag cactggcaga agaaagagcc aataacggag tacgctcact ggataatgtc
     4201 accgtctcaa ccatcacttc tcataaagcc ggatatatcg acaaagaaaa cgaactgatc
     4261 gtcggtctgc aaacagacga acttctgaaa cgtgcaatca aacctttcgg aggtatcaac
     4321 gtggtgagca aagcctgcca tgaaaacggc gtggaagtgg acgaccgtgt aaaagatata
     4381 ttcactcact accgcaagac gcacaatgac ggagtatttg acgtatatac cgaagaaatc
     4441 cgttcgttcc gttctctggg attcctcacc ggacttcctg ataactatgc ccgcggacgt
     4501 atcatcggcg actaccgccg tatggctctc tatggtatcg accgattgat tgaggcaaaa
     4561 aaagaagatt tgcgtaacct taccggtccg atgaccgaag cccgcatccg cctgcgcgaa
     4621 gaagtggcag agcaaatcaa ggcattaaaa gacatgaagg taatgggcga atactacgga
     4681 ctcgacttga gccgtcctgc ctacaccgca caagaagcag tacaatgggt atacatggct
     4741 taccttgctg ccgtaaaaga acaagacggt gctgccatgt cactgggtaa cgtctcttcg
     4801 ttcctcgaca tttatatgga atatgaattg agcaaaggaa ccatcacaga atctttcgca
     4861 caggagctga tcgaccagtt tgtcatcaaa ctgcgtatgg tgcgtcacct gcgtatgcaa
     4921 tcttacaacg acatctttgc cggtgacccg acatgggtaa ccgaatccct gggtggacgc
     4981 ctcaacgacg gacgcacgaa ggtgacaaag acttctttcc gcttcctgca aacactctac
     5041 aacctcggcc cttcaccgga accgaacctg actgtattgt ggagcccgga acttccggaa
     5101 ggattcaaag aattctgcgc aaaagtatct atcgacactt cttccatcca atatgaaaac
     5161 gacgacctga tgcgtgaagt gcgccagtct gacgattacg gaatcgcatg ctgcgtatct
     5221 tatcaggaaa tcggaaaaca aatccaattc ttcggcgcac gttgcaacct ggcaaaagcc
     5281 ctgttgcttg ccatcaacgg cggacgttgc gaaaacaccg gtacggtaat ggtgaaaaat
     5341 atccccgtac taaccagcga cacactgaac ttcgaagaag taatgagcaa ctacaagaag
     5401 gtattgacag aaatcgcccg tgtttacaac gaagcgatga acatcatcca ttatatgcat
     5461 gataagtatt actacgaaaa agcccaaatg gctcttgtag ataccaaccc acgcatcaac
     5521 cttgcttatg gtgtagccgg actttctatc gccctcgatt cactgtcggc catcaaatat
     5581 gccaaagtga ccgcacgccg caacgacatc ggtctgacag aaggtttcga tattcaaggc
     5641 gaattccctt gcttcggtaa tgacaacgac aaggtagacc acctgggtgt tgacctggtc
     5701 tatttcttca gcgaagaatt gaagaaactt ccggtttaca aaaatgcccg tcctacttta
     5761 tctttgctca ccatcacttc caacgtgatg tatggcaaga agacaggtgc tactcccgac
     5821 ggacgcgcca aaggtgtcgc ttttgctccg ggagccaacc ctatgcacgg acgtgacaag
     5881 aacggtgcca tcgcctcttt gagttccgta gcgaaattac gttaccgcga ctcacaggac
     5941 ggtatcagca acactttctc catcgtcccc aaatcactgg gagctactga agaggatcgc
     6001 gtagaaaatc tggtgacaat gatggatggc tatttcacca aaggcgctca ccacctgaac
     6061 gtgaacgtac tgaaccgtga aatgctttac gatgccatgg aacatccgga aaaatatccg
     6121 caactcacca tccgtgtttc cggttatgcc gtaaacttcg tgaagttgag ccgcgaacat
     6181 caattggaag taatcagccg tagcttccac gaacgtatgt aatcagatct actcaatatg
     6241 acgataaacg tacattcata cgaaagtatg ggaacattcg acgggccggg cttacggctc
     6301 gtcgtttttc ttcaaggatg caatttccgc tgcctatatt gcgccaaccc cgacacaata
     6361 gccggaaaag gaggtacacc taccccaccg gaagaaatcg tccgcatggc tatgagccaa
     6421 cgtccttttt tcgggaaacg cggaggagtc actttctccg gaggagaacc tacgtttcag
     6481 gccaaagcac tagtcccttt agtgcgtgaa ctgaaagaaa agggaataca tgtatgcata
     6541 gacagcaacg gcggtatctg gaacgaagaa gtagaagaac ttttcaaact gacggatctt
     6601 gtattgctgg atattaaaga gttcaatccg gcacgccatc aagcactgac cggaagaagt
     6661 aacgagcaaa ccatccgcac ggcagcatgg ctggaagaaa acgagaaacc tttctggctg
     6721 cgttatgtat tagtgcccgg atacagcgat ttcgagaaag acatccgcta tttaggagaa
     6781 gctctgggaa aatataaaat ggtgcaacga gtggaaatcc tgccttatca tacattaggc
     6841 gtacataagt atgaagcgat ggagcaggaa tacaagctga aagacgtaaa agaaaatacc
     6901 cccgaacaac ttgaaaaagc tgcggaggta tttaaagagt atttcactac tgtggtggtc
     6961 aattagttga aaaagttgag aattgagagt taactatgca gtatatataa cagtgcgcag
     7021 gcaactctca actctccatt ctcaactctc aaattcttca atcacctcga aacagggaca
     7081 ctctttgatc cgctcccaag ggtcaacaat tccattataa ttagtatcag gactcaagtc
     7141 ccggtgaccg accatcttta catccggata acgctgcaac aactcgctta ccagacgatg
     7201 catcgcctct ttctggcggg aagtacgtgt atccgctgcc tttccgtcct catccagtcc
     7261 gccttcatag cacaccccta aactaatcgc attaaaaccg cgtgcatgag cacccaccgt
     7321 atcttcatcc ctcatcggct ctatctgtcc cgacttgcgg atataataat gataccccca
     7381 acacgaaaag ccccgaaagc gatgggcagt gtccacatcc ttcgccgtga agtcgcgatc
     7441 agcacgggta gcagagcagt gaatcacaat cagactaatc tttctcatcg tccttctccc
     7501 tttccgttgt tttcacatta cacacttcct tatgggtagc attgaagcgc acctctctca
     7561 caattctgtt ccgctttctt tttccgaaga aaggcacaag gaacatgatt acatccaaaa
     7621 tcttagttac aatttctttc atttgatcca atattaaagt tatcatgctg ccgggtccgg
     7681 agcttctccg cttccaccac cgtctgaacc accaccggaa cctttgtcat cgtcttctcc
     7741 ttcattgccg ctaccgcccg tttgggccac cgcacgcgtc gttacctgct ggtagctaag
     7801 aatcttcgtg atgtccgcca acgtctttcc gggacggaaa ataatatggg cagccgtaat
     7861 cagcgaactt gaaaactcct tgaccgacac agctccttca ctgttcaacc cgatctgcaa
     7921 actgcccaaa tcacccagcc ggactattct tcccgctttc aacgcacgct tcgcctcata
     7981 aagaataccc gaaatggcgg cacgcacatc tgtctccgta caggtagacc ggctggtgat
     8041 tccctcgcac aactcttcaa aatccaactc tcccgaagcc tgtgcctgcg cgtaatactt
     8101 tgccgactca tcctttttgg caggattctt gcgcggcact actgaataag ttactgtcat
     8161 tgccataata aaataatttt aagatttcac acatttcgaa cgcgttcctt atttgttaac
     8221 gacataaaga taacacattt tccaccctcc ggattcccca acgaagtttc ctgatactct
     8281 atgaataata atgacgttat tcttttaata aaccattaat tttcagtaac tttatagcat
     8341 aaatcaaaca tcattcatca tgtattatcc ggaccaaccg tttcttatcc gcacttataa
     8401 aaagtcggaa ctagctcatc tttacaaccc caacgtatgc ctcaaagtag ccttacaaat
     8461 actacgtcgt tggattgtct acaaccttcc gctcctgcaa gaactcgaac aagaaggcta
     8521 tcgtgcccgc aaccgccttc tctctccccg gcaagtggca acgatcatac gctatttggg
     8581 agaaccctag gaacttaatc aaaaaaacga aaagttccat tctattattt tacaaacaaa
     8641 tttctttgca accgcaaatt aaaaagaaca aaccaacatg gagcatttta ccatctttca
     8701 agacttttac cgcgtcatag ccgaaatgac agaagaagaa atcgtatcgg ccatcagcaa
     8761 cggcacatac caggaaacag tggaggacgt gcgccgaatc ttcacggaac aaggcgagaa
     8821 agcagccaac gaaaagaaaa tagaactacc ggaaatcacc ttttcagcca actaccgggg
     8881 aggacgttca aacgcaactc tcgtcaagta tctgggatac atcgtggtag acatcgacca
     8941 tcagacacag gaagcattgg cacgcatcct cgcactggca aaaaagtgtg cccacacccg
     9001 catcgctttc atcagtccca aaggaatggg actgaaaatc gtggtacgtg tatgccggac
     9061 ggacgggaca ttgcccgaaa cgattcagga aattgaagat ttccatcatg ccgcttatca
     9121 caaaatcgct tccttttatg cccagctctg cggagttgag gtcgacactt ccggacaaga
     9181 tgtcagccgt acttgcctgt tctcttacga tccggatatt tatttcaatc ccgatgccac
     9241 agctgtcatc gtggaacagc caccgatgtt cttcaagtct caaaagaaga aaagggcatc
     9301 cggcaaaaag aagaagacga cagcaccaga caacaatccc ctcaccgaac aagtggcact
     9361 caactaccat tcctcgcacg cttccttaat ggtgactctg aactattatc acaataaatc
     9421 cgaaaagtac gtcaccggca accggaacaa ctacctgcat tgcctggctt gtatgtacaa
     9481 tcgctacggc gtcccccagg aagaggcggc agcttttatc aagagccagt tcaccgatct
     9541 tcccgcggat gaaatggacg cactgatcgg gagtgcttac ggacacaacg aggaattcga
     9601 cacccgcaag ctgaatagta cgcagaagcg aatattacag attgagcaac atatcaaaga
     9661 aaattacgat acacgctaca acgaagtgct tcatatcatg gaatatcgca gaaggaaaac
     9721 ggacacggag caaccggaac ctttccatat tctcgacgaa atgatggaaa acagcatttg
     9781 gatggagatg aacgaactag gctattcgtg caccgtcaaa acgattcaga atctgatcta
     9841 ctccgacttc agcagcactt accatcctat tcgcgagtat ttagactcgc tgcctgaatg
     9901 ggacggaacg gattatatcg gtatccttgc caacagcgtg catactagtc accagaaatt
     9961 ttgggtagaa tgtctggaac gttatctggt gggaatgtgc gctgccgcca cacaagatga
    10021 tgtggtgaac cacactgttt tgttgctttg cagcgaaata cagaacattg gaaagactac
    10081 gtttatcaac aacctgctgc cgcccgaatt gcgcgcctat ctttctaccg gtcttatcaa
    10141 cccgaacaac aaggatgatc tggccaaaat agcgcaggcg atgcttatca atctggatga
    10201 gtttgaaggg atgaacggac gggaactgaa tatcttcaag gatttggtta cccgcaaagt
    10261 aatcagcatc cgcctgccat acgcgcggcg ttcgcaaaac tttcctcata cggcttcttt
    10321 tgccggcaca tgcaattacc aggaagtgct tcacgacacc acaggtaacc gccgttttct
    10381 ctgctttcat gtcaactcga tggagtttat caaaataaac tacgcgcagt tgtatgcaca
    10441 aatcaagtat ctgctcaaca agccggggta tcagtattgg ttcacccagt cggaaaactc
    10501 acggattgaa gagaacaacg aggatttcat tttccactca ccggaagaag aactggtgtt
    10561 gacacatatc cgcaaaccgg aacgtttcga aaaggtgcat tatctgacgg tcactgaaat
    10621 tgcggaattg attcgcgaac ggacggggta tcaatattct cacggaacca aagcccaact
    10681 aggaaaagtg atgtccaaac acggcttcga atttcataag ggaaaaaacg ggagaagata
    10741 cactgtattc attattgata cggaacaggt gaaatcaaac aggctatatg aataagattt
    10801 catctccttc gcacgcaaaa aggtgagggt tggtgagggt acttttgcaa cttttcattt
    10861 ttatatttct tatttctatt cttctatttt cttctaaaaa aaatacgaat gttagaaatt
    10921 taccctcacc taccctcacc ttttcctttt tcttcctcaa aaaaacggtg ggaaatttga
    10981 aaaagacagt tatctttttc aaatttccca ccatgttttt ttaatcgctt cttataaaga
    11041 catcgaaaat tctatcctac aacctaacgc attcatgata cgatagaagg tagaaacctt
    11101 aggttctgtc tgaccacttt ccactcttga aatataagaa cggtcggaac cgatacgccg
    11161 ggctaactct gcttgagtaa tcttagcctt tttccttgcg tcttcgataa tttgcccggt
    11221 gtagaaagca tacgcttttt cttctgcttc cgcacgttcg ggagtacctt ctgctccaaa
    11281 tttcgcatca agaacagcgt cataatctac tatttgatga ttgtttatct gcataatatt
    11341 cctcctttat ttttaatgct ttatctattt cactacccgg tgttttttgc gacttctttt
    11401 gaaagccatt aaacaacact acaatatttc catcatcaaa aatgaaaaat acccggtata
    11461 tattaccatt atattctgta cgaagttcaa aaactccgtc ctgaacaaat tttacaaatt
    11521 tagtagagag tctttcttgt gttttcaaca agagtagtcc atactggatt ttatcttgtt
    11581 ccttttcggt taaagtctcc atgaaagcct caacgtaacc tccgtatgta cggaggttac
    11641 gttgaggctt tccatactgc aaatatgcga attgttgttc aactatacaa caatcatctt
    11701 tttattttat attatttttc ctcaaattct cctgcacgct ttttcttctc ataagacacc
    11761 agcgtctcta cactaagcgt tttcccattc ttagggctta tcacatctac aacgcttgct
    11821 aacgcacgaa aagtctgttc gcaatttgct actccgtcat acgtcaacct acccagattg
    11881 atggcatcga gcacaacaga gacatattgc ttcggatttc cccgatactc gatgatgaca
    11941 ggcgtgagat gcgacatctc tcgagtcagt tgactgacga ttcttttttt tggtcgagca
    12001 gatccattaa tttttcacta tgcacattga tttgtgcggt tacttcacga agttcgtctt
    12061 tcaatgaaca caataattca tcattcaatg aattttccat aaaactttct atttaattga
    12121 ttataaaaaa gccattccag aaagataagc aatcattact tacttcccgg aatggtgtct
    12181 aatacctcga aaacaaagac ttatattcta acctaatgta ctcactttaa tccatttctt
    12241 ttgattttgc attccatacc agcaaagcaa acaacaccga aagcaaagca gcaccaatcc
    12301 aaaaccaatt gatataggtg aagtcataaa catctactcc attctgaaca gtcttttgcc
    12361 cttctatcag tataccgctc atcacgtcct gcaatccggc accgatgtaa ctggcaatgc
    12421 cgactactcc caatgcagca cccgaagcat tacggggagc aatatccact gccatcaaac
    12481 cacccagaaa acagatcaaa actccgatac ctaaaccgaa aagaaccatt gccaacacgt
    12541 ctatccaaaa atgagctccc ggaactaaga gaaacaaaca aagtgctatt acattcatca
    12601 acccaaatac taaagctgga atattacgac gtccaccaaa taacttatca gaaataacac
    12661 ctgaaaacat agtaccgatt ataccacaga ccggacaaat agaaatgata aaactggcat
    12721 ccaatgtaga gtaccccttt tgagcttcca aataaaaaac gccccaacta ttgatagcat
    12781 aacgactgat atacataaaa gcactcgaaa gagccagtat ccaaatggca ggcatcagca
    12841 atacctgacg ctgtgcttta ttaaaatcag ccgtttctgt ctcactcatt tcctttttct
    12901 gtttgggaac attcaccgaa ggaaatccca tgctttcggg agtatcatgg aagaacttcc
    12961 agactatcaa cgctcctatc aatcccacta taccggctcc gaagaaacca taccgccagc
    13021 ccaacacact gacaattgag gctattatca gaaaagtcaa cgcttcgccg atattatggc
    13081 tcgcagacca aaagccatag tatgaaccgc gctctttgtc cgtgaaccaa cgagaaagcc
    13141 ctactacaca agaggctgct cccatagatt gaaaccagcc gctaatcccc caaaggatag
    13201 cgaacaggat aaaagaatta gtaaaaccga gacagaggtt aaccaaagca gttatcaata
    13261 aaccggtagt cataaaacgg ttgatattac tacggtcggc aaggaaatcg ttcgtgaatt
    13321 ttccgatggc ataggtgaaa aacaatacgg aacctatgat gcctaactct gtttccgaaa
    13381 aaatgccttc atctacaata ggtttcttta cgacattcag gctaagacgg cacacataat
    13441 acataccgta accaaaagtc gcagaaagga aagtagacca tttcagaaac ttcagacggc
    13501 gagcatcgga tgaagacaaa gcttctccgt tacaaggtct cggcgaagag accttgtaaa
    13561 aattgattag ttgtttcaac atgaagaaag tgcgtttagt cgtgaagttt cttttcgcgt
    13621 agatactcta ataatagagc tgggcggtct gtttgaatta gcttggctcc ctggccaatt
    13681 atccaccccc aactttcatc cggctgatga agttctactg cacggtcgtc gtcatgcccg
    13741 ccacatagtt cgggccaaag cgaatttata aaaagattag agcctgtatt acgtactttc
    13801 tttatcaaat taagaatctc cggactgtca ctatcaaaca ctaattcata agcagcaggt
    13861 ttcatatgtg tctgataact atcaatgaca gcttccgccc cgtctttatg aagttgtaca
    13921 ataggcatga agattacctt atccaataca tcaccgtttt cagccttgac ttgttcataa
    13981 ggaagtccgg ctttaataat acattgctga acagttcctg tttctttcaa aacagcatat
    14041 acatctttga agtaatcata gcctttatca atattaacaa ggatcttacc tttacataat
    14101 gacattactt cttccaatgt cggtatcaaa tgagctgttt tatgccctgt accacttttc
    14161 aaacggaact gacgtaattc ttccaatgta tagtctgccg gataaccttt tcctgttgta
    14221 gtacgatcaa ttttcttgtc atgcatcaaa atcagatgtc catccttggt tttcttcaga
    14281 tcgatttcaa ttacatctac ccccatatca atacaattct ggatagcctg cagggagttc
    14341 tccggagcat tacgccagtc agctcgatga gaaacaacta aaactgaatt acttgcaggc
    14401 ttctgtagat tcgcaattat tttatccgaa tgattctgtg cctctaaccc tcctattatc
    14461 agaagggtta aagctattaa tatatttatc tttctaagca tatcttttta tttttgtaaa
    14521 gcatttcttt ttgcattctg tccgcgctgt gcccatggtg aatttgcagg cccttcaata
    14581 ccacaatcaa tagctatcaa tttgcaggca ccattatcct catacgtgac atacacaata
    14641 ccatagtcag caatgactgg tgacgaccaa attttagaac ctaattgtct cttatatttc
    14701 tccgtaccat cagcattcaa tattatatag ttaccgtcat catcacagat gtgaatattt
    14761 ccgtcactgt ctatagccgg tgttgttcct atttcagcga cagaggaata actccatttc
    14821 tttgctcctc ctttagtcag ggcaacaact tgggcattcg gattctttgt acccacatag
    14881 atggttccgt cagcaccgat agccggtcct ccctggtcaa tcttgcccat agtaccactc
    14941 gccggatatc tccacaactc attaccctgg ttatcataag ctgcaaccac tccttcagaa
    15001 aatgccacat atacatttcc ttgcgcatca atagcgggat atacagctgc agccgtattt
    15061 cctttcccta gattaggaga caagttcaca ccatcttgcg tagtacgggc aaatccgttc
    15121 gctcccgaca aggctgaata gataactcca ttctgtccaa ccgatatacc accattagca
    15181 ccaccattgg gagatttgcg tctccaaaat tgtctgccgg aactacggtc aaccatgtgt
    15241 acagaaccat cggtccctct atttccaatc aagatattgc catcacgaga caaagcggga
    15301 gaaatatagg gaatattagt accaatacct agttcatatc tccacttttg tgttccatcc
    15361 ggatgaatag catacagact gctgcttatg tttttatctg ttgtacttgc acccatataa
    15421 atagttccgt ccgcacctac cataggagac gaaccttgat ttcctgctcc tccgtccttg
    15481 cttaaatcaa acatccattt ttgctctccg gacggcgaat aagcaaaaag gtggagtgca
    15541 ttggatgaca catatacatc cccattgtca ccaacagcag gagagataga ccgtaaagaa
    15601 gaggatacct caaacgtctt atcccaaagg acagttactc cggatataga agtatcacga
    15661 acgtataaag tagcttgctt tgtatttgta gctccacgat catcagtagc tgtcagcttt
    15721 acagttacaa atcctgttgt cgtgaaagtt atttccgggt ctttttcttg agaagtctgc
    15781 ccattgccaa aatcccactc gtaagaaaca atttctccat cctcatccac agacttatcg
    15841 gtaaattgaa ctttctcatt cactttacaa atggcagggc tatagctgaa gtttgtaacc
    15901 ggaggcatat tcgtcggacg aatcacaaca gtatgggatg cagttgcata tcctccgaat
    15961 tcatctgtca cggttaattt aataacatag gttccagccc tcttatacaa aacggacgca
    16021 tctttagtag tagccctatt cccttccccc tcaaatccaa aatgccagaa atactctact
    16081 atctctcctt ccgtctttac tgattcatca gtcagataaa cgatatcacc gaccgtatat
    16141 tcttctttat ctatagaaaa agaagcctcc ggggaggttg tctgccgcac ttcatcgccg
    16201 tccttacatg caaatagaca aacgactgtc actatcagga atatatattt cttcataatc
    16261 attctattca ttatttaaga ttaaaaccaa ttatctttta cctctctgtt tcagataggc
    16321 atccagcaac tggggatggt ctgtctgtat caaattaatc cccttcgaca aaatcaagtc
    16381 cactcctgta tagtttcctt gtgtcatctg tgtatcatag gtataaccat tcatatctaa
    16441 catattagtc gagacaaaca gcccttttga agatatggct gtcgagagcc cgccatttaa
    16501 tgttttcgac aaagatatct gggcaaacat cactcctggt tgctgtgaaa ggaaatctgc
    16561 atgctcctcg ttttcacact gcggataagg tataggagcc ggcgaataat ccaaaatatt
    16621 ctgcaagaca tcccgattat tagatgtata aaagaacaca cggtctaaca tcccacagct
    16681 tttcacaaca tcatacagtt ctttaggaga cactttattc aagaagtcca aatcaaaaaa
    16741 gatctttccc cgccctgcaa ccaatgcgtc atacaaagag gggaccgtgt gattggttac
    16801 tgtgccgtct gccagcttca gacgataaga ctggagctgc tcataagtca aatctttcac
    16861 tttccccttc cctgtagttg tcctgtctat ggtttcatca tgcatcaaca caattactcc
    16921 atcctttgtc atgcgaggat ctacttctac aatatctaca gctccc
//
