LOCUS       gnlProkkaNAOKALHA_29   13542 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NAOKALHA_29.
ACCESSION   gnlProkkaNAOKALHA_29
VERSION     gnlProkkaNAOKALHA_29
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 15:48:39
            Original ID  :: gnl|Prokka|NAOKALHA_29
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 70390
            Orig. end    :: 83932
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13542
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:8542]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8542
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13542
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13542
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             59..748
                     /locus_tag="ctg29_61"
                     /transl_table=11
                     /translation="MKLGIMQPYFMPYIGYFQLIKAVDKYVVYDDVNYIKGGWVNRNNI
                     LVNGEKKMFTITLKGASAYKHFNEIEIGDDFRKFMKTLELNYSKAPFYHETMELLYRII
                     MFPNRQLALFLANSFKEILDYLNIQTEILLSSDLPKDCSLKGKDKVLHICKLLSADTYY
                     NAIGGKQIYNKEDFMQNGINLKFVDTIIKRYPQQSKEFVPYLSIIDVLMNNSKEETCML
                     LDSFSLQ"
     CDS             745..1710
                     /locus_tag="ctg29_62"
                     /transl_table=11
                     /translation="MMSIGGYFELEIREGKHFHQGAIKLSTARQCFEYILKARRYTKVY
                     IPYYTCDVIIEPLMKLNVKYEYYHINSLLDPVFDKKIESSEAFLYTNYFGLKQDTVLYL
                     SRFYPNLIVDNAQAFFAKPIEGVDTFYSARKFFGVPDGAYLYTTALLDIDFPIYNPIDN
                     INYLIGRITDSAEGYYKDFQESEERMSNQEIHRMSVLSDKILSSLDYVSIIERRRFNYH
                     LLYSALTAFNKFDFSISENQNVPLIYPFYTSKAGLRQQLILEHVYVPQYWQNVVNKIDA
                     KCLEYSIANNMIALPIDQRYDEKTMNILIEKISNLNNHLS"
     CDS             1707..2702
                     /NRPS_PKS="Domain: NAD_binding_4 (91-233). E-value: 3e-07.
                     Score: 21.7. Matches aSDomain:
                     nrpspksdomains_ctg29_63_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     114.5; E-value: 1.1e-34)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_63"
                     /transl_table=11
                     /translation="MKKKIIIFGATGNTGSYLLEYALNFFNKEEYEIIASGRRETTFFS
                     KRGIPYYSVDITKEEDFDKLPMENIHAVMLLSAQIPSYMDTYCPIKYLDSIVIGGFNVL
                     EYCRKCHVDRIIYTQTVFDISLYSHDTILKPDMKPNFSYTGDHAIYVISKNTALDLIEH
                     YYQEYGLKKFIFRLPTIYSYSPYPYYFPNGVKTKRPIYQMIENAQKGLPIEIWGDPHYA
                     KDMVHVNDFSQMLCKAVEVEQESGFYNVGTGMPITLEEQIRTIISVFSPKESPSEVIYR
                     PDKVCGGGYIMNIENAKKELGYVPQYDCRKLFEDYKSEMEIKRFAELRLK"
     aSDomain        1980..2405
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg29_63_NAD_binding_4.1"
                     /evalue="3.00E-07"
                     /label="ctg29_63_NAD_binding_4.1"
                     /locus_tag="ctg29_63"
                     /protein_end="233"
                     /protein_start="91"
                     /score="21.7"
                     /tool="antismash"
                     /translation="YLDSIVIGGFNVLEYCRKCHVDRIIYTQTVFDISLYSHDTILKPD
                     MKPNFSYTGDHAIYVISKNTALDLIEHYYQEYGLKKFIFRLPTIYSYSPYPYYFPNGVK
                     TKRPIYQMIENAQKGLPIEIWGDPHYAKDMVHVNDFSQ"
     CDS             2703..3635
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_64"
                     /sec_met_domain="Glycos_transf_2 (E-value: 7.7e-25,
                     bitscore: 80.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGSITVSICCLTYNHEKYIRQCLDGLIMQKTEFDFEILVHDDAS
                     SDATQSIINEYVVAYPNLIKPILQIRNQYSQGISPLRQILFPLVKGKYVALCEGDDYWT
                     DPLKLQKQVNAMESDHSLAGCAHQSLVFYENGTPSHMFHHVKKQILKTKDLLDVRLFHT
                     ASFLFKKEVLDYIKDFNSSLYAGDRFLFLACSLKGNILYMPDVMCCYRKNAMGVTSRVS
                     YSLHVLDLKVPEYFHNKDLKFPYYRYLAFVHRAIFSESLDISLKKYIYHFTLFVKYSFS
                     YFPKNLKDIYKALYVSFWWLTKGQKYRIK"
     CDS             3632..5011
                     /locus_tag="ctg29_65"
                     /transl_table=11
                     /translation="MIAIIFLILFLIQILISNRLIIDSFSRKISFIYLLWWGTAIVIST
                     FDPAELYSVSMKTYMLLLINVWAFNWGFLCFGKIKKIRLKVTTDNSFYNLVIGNNKMIL
                     LLMLACIVTYYYAMKFALVIELYGAGEGRMMRFEAGELFTSNLEVYLYDFLIKPFTQFV
                     MLIVACMLLSKIKRRILLLSVLFLFLYASVGNGRGGLIVFLFYCFIIYYLRRELYYINL
                     LASKRKKWNFGVVSFVCLFVGVGIIVVVISYMTAQRMGFDTFSAEVVKIGFEELKSQAV
                     WYFLGPFRALDYSFRANYESITGFWYGRATMGGIDNLLKLVIHYLGGSYTIAHDEIGHL
                     LQNSKISVGNGIIFNYAYTNIIFHYLDFGYVGVLLFPFLYGFIVRYSIYKFTQKPTLLT
                     LGIMIYLVYISMFNIFSWEFQKPSSIIYVLLLLFFQYVYSHKFVILKLNGKKKGLCRHE
                     C"
     CDS             5001..6278
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 202.7;
                     E-value: 1.2e-61)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_66"
                     /sec_met_domain="CTP_transf_like (E-value: 2.9e-11,
                     bitscore: 36.8, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 8.4e-119, bitscore:
                     388.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.8e-63, bitscore:
                     206.7, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADIIHPGHLNIIHEASKLGHVTVGVLTDSAIASYKRLPYLNFD
                     QRSLIVLNLKGVDEVIPQTTLDYVPNLELIRPNFVVHGDDWKEGIQQETRQRVIDTISK
                     WGGKVIDVPYTKGISSTLLNTRLKEIGTTPEIRLKRLKRLIAAKSIVRICESHSGLTGL
                     IIENTSVEVNGVKREFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDLNDALECTTKPVI
                     FDGDTGGKIEHFVFTVRTLERLGISAVIIEDKIGLKKNSLFGTDAVQTQDTIEGFCDKI
                     QAGKRAQITDDFMIIARIESFIAGKGLDDALGRALAYIKAGADGIMIHSKDKSGEDIKN
                     FCLALRKIHKSIPIVVVPTTYNHISEDELASWGVNVVIYANHMLRSAYPAMLNTAKSIL
                     ANARSYEANDLCMPIKEILELIPGTK"
     CDS             6310..7440
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 69;
                     E-value: 6e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_67"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2e-16, bitscore:
                     53.2, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.2e-20, bitscore:
                     65.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISPNIFVDSLGAMQMDFFTGVPDSLLKNICAYLTDHLASEHNII
                     AANEGAAIGLATGYYLATRKIPVVYMQNSGLGNAVNPLMSLTDKEVYNIPLLLLIGWRG
                     EPGVKDEPQHIKQGKVTLPLLEAMGIRYAVLSQDEKKFISQLNVAKSYMDETREPFAFV
                     IQKDTFLEYSSENCEDERLSLKREAAIHFIAASLTEKDIIISTTGMISRELFEYRESTS
                     LEHERDFLTVGSMGHASQIALGIALKKRDCKVYCFDGDGSTLMHMGSLAIVGSLHPENY
                     VHVVFNNGAHDSVGGQPTVALDIDLCKIAQACGYEIVLSVSDNEGLCEALKKIQQIRGP
                     ILLEVKVRKGARKNLGRPANTPIQNKEAFMLFLDNL"
     CDS             7448..8542
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_68"
                     /sec_met_domain="Fe-ADH (E-value: 1e-75, bitscore: 247.9,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQRFFLGESSIKELIPILQEYTPDHIFLVRGKNSYEKCGAQAVL
                     ESVFVKLACGVTEFFDFEANPKIEDMEKGLSLLKEYPTNMIIAIGGGSVLDMAKLLRFF
                     YSYSGNPTGGEFEKKRQLIPLITLPTTAGTGSEATHFSVLYKDKVKYSVEHDAILPDVA
                     IVYPKFTYGNSKYLTSCTGFDALAQAIEAYWNVNATEESDKYAAKAIKLLWPNLPLVVN
                     SPTAEARNKVSEGSYWAGRAINITKTTAPHAFSYSFTTDYGYPHGHAVALTFPFFMRYN
                     IGNSDILLNPNINPYLYKIKMQKMLQWLNMECVDVAIAMKEYIRNLGLDIDISQIDISK
                     IVSSVNIQRLINNPYKVEAICLEE"
     CDS             8527..9243
                     /locus_tag="ctg29_69"
                     /transl_table=11
                     /translation="MSRGISEKEQRWLLVLSQVIEVLDKNNLLYFIDTGTLLGAVRDKM
                     FIPWDNDIDLAVIGGDTSTTNLLKVSKLLYALGFYVTLTKKEIAICSRDGVNLGIKLYK
                     KQASHYEACMGKVYRHRLFYSINLYLSGEVLYKKGFSFKYKAISLFVKFSQVFKLKLSC
                     IWQMKLLFWAKYDEKTVIIPFEFVDAIIDYNFYNIIVKVPNKPERYLAYRYGENWKVPK
                     QDYDYMIDDKSIINID"
     CDS             9250..9339
                     /locus_tag="ctg29_70"
                     /transl_table=11
                     /translation="MKTNFNIRSIIVINKIIINFFFRQYRWYL"
     CDS             9398..10513
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_71"
                     /sec_met_domain="Glycos_transf_1 (E-value: 6.6e-12,
                     bitscore: 38.5, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNILINCSNLKKGGGLQVADSVCSCLNTIPQHDFFLVLSSCMDDT
                     ADRVSEYKNVTVVRHDIRNSWYTLFWGRDKAMDNLVTRHNIGGVLTIFGPARWKPKCKH
                     LCGFARSHLVLNDSPYFQRMSWKELMIEKARNLYLYYYFKRGVTAFWTENPYISEKVKH
                     LFPTIKAYTVSNYYNQVFDDENTQIEHALPSFDGCTLLSINAPYPHKNLAIAIEVARYL
                     KKHYSEFSFRFVFTVTENDLPPIPSYLREHFCLIDKVSVAECPSLYRQADIMFQPTLLE
                     CFTATYVEAMRMQVPILTTDLPFAHGLCGNAAVYYSPLDAEDCAKSIYKMAVDTSFQDY
                     LVGEGIKQLKSFDNYNRRAEKLIDLISNLDD"
     CDS             10528..11601
                     /NRPS_PKS="Domain: NAD_binding_4 (10-144). E-value:
                     2.6e-07. Score: 21.9. Matches aSDomain:
                     nrpspksdomains_ctg29_72_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 105;
                     E-value: 8.3e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_72"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 4.8e-108,
                     bitscore: 353.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 8e-08, bitscore:
                     24.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFKDKVLLITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQD
                     DMRHHLQNPKVKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVI
                     GTDNVLESAIAHGVKNVVVLSTDKAAYPINAMGISKAMMEKVAIAKGRALGEEAGTTIC
                     CTRYGNVMASRGSVIPLWVEQIKNGRPITVTDPNMTRFMMTLDDAVDLVIYAFEHGHNG
                     DLFVQKAPAATLDVLAQALKETYAQVDPKYGETEVKTIGTRHGEKLYETLVTREEMAKA
                     VDMGDYYRIPCDTRDLNYDKFFTEGNEDIARIEDYHSHNTARLDVEGMKKLLLKLRFIR
                     EDLGMEEKAKSAEIKSE"
     CDS_motif       10555..10611
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg29_72_0001"
                     /evalue="1.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg29_72"
                     /protein_end="28"
                     /protein_start="9"
                     /score="11.1"
                     /tool="antismash"
                     /translation="LITGGTGSFGNAVLRRFLD"
     aSDomain        10558..10959
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg29_72_NAD_binding_4.1"
                     /evalue="2.60E-07"
                     /label="ctg29_72_NAD_binding_4.1"
                     /locus_tag="ctg29_72"
                     /protein_end="144"
                     /protein_start="10"
                     /score="21.9"
                     /tool="antismash"
                     /translation="ITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQDDMRHHLQNPK
                     VKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVIGTDNVLESAI
                     AHGVKNVVVLSTDKAAYPINAMGISKAMME"
     CDS             11702..11923
                     /locus_tag="ctg29_73"
                     /transl_table=11
                     /translation="MAATVLNSVQQHLLKMFAFDGSEERLNEVKEVLTKYFSQKLDDRL
                     NDLWDSGVLNQEKLDELRKIDVRTLPKR"
     CDS             11920..12324
                     /locus_tag="ctg29_74"
                     /transl_table=11
                     /translation="MNRIVLDTNSLIQCISPKSRYRKIWDCFLDGTNQLCVSDEILNEY
                     EEILERLAGVEIAKLVIDVILNNPYTLFFTPYYNFNLIKSDPDDNKFVDCAIVANAKFI
                     VTEDHHFHILKQYNFPKVSFIGLDDFCHSL"
     CDS             12365..13513
                     /NRPS_PKS="Domain: NAD_binding_4 (101-190). E-value:
                     5.2e-09. Score: 27.4. Matches aSDomain:
                     nrpspksdomains_ctg29_75_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 91.1;
                     E-value: 1.4e-27)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_75"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 4.3e-10,
                     bitscore: 32.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILVTGSRGFVGRNLVSQLHNIRDGKARNYGIAGEELTIYEYDM
                     DSDPAELDVYCRQADFVFNLAGVNRPKDASEFMKGNFGFASTLLDTLKKHGNTCPVMIS
                     SSTQAALDNPYGESKRAGEQLLFEYSRETGAKVLVYRFPNVFGKWCRPNYNSAVATFCN
                     NIAHDQPIRVNDPSVVMHLVYIDDVVDELISALSGKEHRNGDYCEVPVVHTITLGGIVE
                     LIRSFRQMPGTLSVPDLSDAFTKKLYSTYLSYLPEERFSYPLKMNVDDRGSFTEIIRTS
                     DRGQFSVNISKPGVTKGQHWHHTKNEKFVVVSGHGLIQLRKIGTEEVVSFEVSGGRMEV
                     VEMIPGYTHNIVNLSETEDLVTFMWCNECFDPARPDTYFEKV"
     aSDomain        12668..12934
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg29_75_NAD_binding_4.1"
                     /evalue="5.20E-09"
                     /label="ctg29_75_NAD_binding_4.1"
                     /locus_tag="ctg29_75"
                     /protein_end="190"
                     /protein_start="101"
                     /score="27.4"
                     /tool="antismash"
                     /translation="MISSSTQAALDNPYGESKRAGEQLLFEYSRETGAKVLVYRFPNVF
                     GKWCRPNYNSAVATFCNNIAHDQPIRVNDPSVVMHLVYIDDVVD"
ORIGIN
        1 caatgtattg tggattgtcg aatgaagatg ttgaaagaat tttaaatctg atattgaaat
       61 gaaattaggt ataatgcaac cttattttat gccttatata ggttatttcc agctaattaa
      121 ggctgttgat aaatacgttg tatacgatga tgttaattat attaaaggag ggtgggtgaa
      181 tcgtaacaat atattggtaa atggtgaaaa gaaaatgttt actatcactt tgaagggggc
      241 tagtgcctat aaacatttca atgaaataga gataggagat gattttcgta aatttatgaa
      301 aacattggaa ttgaattact ctaaagctcc tttctatcat gaaacaatgg aattgttgta
      361 taggataatt atgtttccaa atagacaatt ggctctcttc ttggctaata gttttaaaga
      421 aattttagat tatctaaata ttcagactga aatattgcta tcttcagatt tacctaaaga
      481 ttgctcttta aaaggaaagg ataaagttct tcatatttgt aagttactat cggcagatac
      541 ttattataat gctataggtg gaaaacaaat ctataataag gaagacttta tgcaaaatgg
      601 tattaatttg aaatttgtag atacgataat aaaaaggtat ccccagcaat ctaaagaatt
      661 tgttccatat ttatcaataa tagatgtact aatgaataat tctaaagaag aaacttgtat
      721 gttattagat tcatttagtt tacaatgatg tcaataggtg gctattttga actggaaata
      781 cgtgaaggaa aacattttca tcaaggtgca ataaaactga gtactgctcg tcaatgcttt
      841 gagtatatat taaaagctag acggtataca aaagtgtata ttccatatta cacttgtgat
      901 gtgataatag aacctctcat gaaattaaat gtaaagtatg aatattatca tataaatagt
      961 ttactggatc ctgtgtttga taaaaaaata gaaagctcag aggcttttct atatactaat
     1021 tatttcggct taaaacaaga tactgttctt tatttatctc ggttttatcc taacttaata
     1081 gttgataatg cacaagcttt ttttgcaaaa ccaattgaag gggtagatac attttattct
     1141 gcccgtaaat tttttggagt tccagatggc gcttatttgt acacaactgc gttactggat
     1201 attgatttcc cgatttataa tcctattgat aatattaact acttgatagg gcgtataact
     1261 gactctgcag aggggtatta taaagatttt caagaatctg aagaaaggat gtcaaatcaa
     1321 gagatacata gaatgtctgt attgtctgat aaaattttgt cttctttgga ttacgtctca
     1381 ataattgaaa ggcgtcgttt taattatcat cttctctaca gtgcattaac tgcatttaat
     1441 aaatttgatt ttagtatttc tgaaaatcaa aatgtcccgt tgatatatcc tttttatacg
     1501 agcaaagctg ggcttcgcca acaattaata ttagagcacg tatatgtacc tcaatattgg
     1561 caaaacgtag tgaataagat agacgctaaa tgtctggaat actcaatcgc gaataatatg
     1621 attgcattgc ctatagatca gagatatgat gaaaaaacaa tgaatatatt aattgaaaaa
     1681 atatctaact taaataacca tttatcatga aaaagaaaat tattattttt ggagcaaccg
     1741 gtaatacagg gtcttatttg ttagaatacg cattaaattt ctttaataag gaagagtatg
     1801 aaataatagc ttcaggacgt cgcgaaacta cttttttttc caaaagggga ataccatatt
     1861 attctgtgga cattacgaag gaagaagatt ttgataagct tccaatggaa aatatacatg
     1921 cagttatgct actctctgct caaatacctt cttatatgga tacttattgc cccataaagt
     1981 atttagattc tattgtaata ggaggattta atgtattaga gtattgccgc aaatgtcatg
     2041 tagataggat aatttatact caaaccgttt ttgatatttc attgtattct catgatacta
     2101 ttttaaaacc cgatatgaaa ccaaatttta gctatacggg tgatcatgct atatatgtaa
     2161 tttccaaaaa tactgcttta gacttgatag agcattatta tcaagaatac ggtttgaaaa
     2221 aattcatttt taggcttcca acaatatata gctatagccc ttatccgtac tactttccta
     2281 atggagtcaa gacgaagcga cctatttacc aaatgattga aaatgctcag aaaggactac
     2341 ctatagagat atggggagat cctcattatg caaaggatat ggttcatgtt aacgatttta
     2401 gtcaaatgtt gtgtaaagct gttgaggtgg aacaagaaag tggcttttat aatgtgggta
     2461 caggaatgcc aattacatta gaagaacaaa ttcgcactat tattagtgtt ttttcgccta
     2521 aggagtcacc atctgaagtt atatatagac cagacaaagt ttgtggtggt gggtacataa
     2581 tgaacattga aaatgcaaag aaagaattag gatatgtgcc tcaatatgat tgtcgtaagt
     2641 tgtttgagga ttataaaagt gaaatggaaa taaagcgttt tgctgaatta agattaaaat
     2701 aaatgaacgg ttcaataaca gttagcatat gttgcttgac gtataatcat gaaaaatata
     2761 taaggcagtg tttagatggc cttataatgc aaaaaacaga atttgatttt gaaattcttg
     2821 ttcatgatga tgcgtcttct gatgctactc agagtattat taatgaatat gttgtggcat
     2881 atcctaatct tattaaacca attcttcaga ttcgaaacca gtattctcaa ggtatttctc
     2941 cgttacgtca aatattattt cctttagtaa aaggtaaata tgttgcgctt tgtgaggggg
     3001 atgattattg gactgatccg ttgaagttac aaaaacaagt aaatgcaatg gagagtgatc
     3061 attcgttagc aggttgtgcg catcaatctt tagtttttta tgagaatgga actccatccc
     3121 atatgtttca tcatgtgaaa aaacagattt taaaaactaa agacttattg gatgtaagac
     3181 tttttcatac agcgtctttc ctttttaaaa aagaagtact tgattatatt aaagatttca
     3241 atagtagttt atatgctgga gatcgttttc tgtttttggc ttgttcgttg aaaggaaata
     3301 ttttatatat gccagatgta atgtgttgtt ataggaagaa tgcaatggga gttacttcta
     3361 gagtttctta ttcattacat gtattagacc taaaagttcc tgaatatttt cataataaag
     3421 atttgaaatt tccttattac agatatttgg catttgttca tagagctata ttttcagaat
     3481 cacttgacat ttccttaaag aaatatatat atcattttac tttatttgtg aaatattctt
     3541 tttcttattt tcctaagaat ctgaaagata tctataaggc tttatatgtt tctttctggt
     3601 ggttgacaaa gggacaaaag tatagaatca aatgattgct ataatttttc ttattctatt
     3661 cttaattcag attttgatat ctaataggct tataattgat tctttttcaa gaaaaataag
     3721 tttcatatat ttattgtggt ggggaactgc tattgttatt tctacttttg atccagctga
     3781 actatattct gtgtcaatga aaacatatat gttattattg atcaatgttt gggcgtttaa
     3841 ttggggattt ctttgttttg gaaaaataaa aaaaatacga ttgaaggtta caacagataa
     3901 tagtttttat aatctggtta ttggcaataa taagatgata ttacttctta tgttggcatg
     3961 tattgttact tattattacg caatgaagtt tgctctagtt attgaactat atggagcggg
     4021 cgaaggtcgg atgatgagat ttgaggctgg tgaacttttt acgagtaatt tagaagtata
     4081 tctatatgat tttctaataa aaccttttac acagtttgtt atgctaattg tagcgtgtat
     4141 gctactttct aagattaaac gtagaattct gttgctatcg gtgctttttc tgtttttata
     4201 cgcatctgtt ggtaatgggc gtgggggatt gattgttttt ctattttatt gttttatcat
     4261 ttattattta agaagagaat tgtactatat caatttgtta gccagcaaaa ggaaaaaatg
     4321 gaattttggt gtagtttctt ttgtatgctt gttcgttggc gttggaataa tagttgtggt
     4381 tatttcatat atgacagctc aaagaatggg atttgataca tttagtgctg aggtcgtaaa
     4441 aataggtttt gaagaactaa aaagtcaggc cgtatggtat tttttaggtc catttagagc
     4501 tttagactat tcatttagag ctaattatga atcgataacc gggttttggt atggaagggc
     4561 aacaatgggt ggaattgata atttattaaa acttgtaatc cattatttag gaggaagtta
     4621 taccattgct catgatgaaa taggtcatct tttgcaaaat tcaaaaattt cagttgggaa
     4681 tggaatcatc tttaattatg catacactaa tataatattt cattatttgg attttggtta
     4741 cgttggcgtt cttttattcc catttttata tggctttatc gtacgatata gtatttataa
     4801 atttactcaa aaaccaacat tactgactct tggtattatg atatatttgg tctatatatc
     4861 aatgttcaat attttttcgt gggaatttca gaagccttcc tcaattattt atgttttgtt
     4921 gttgctattt tttcaatatg tttattctca taaattcgta atattaaaat taaatggaaa
     4981 aaaaaaaggt ttatgtcggc atgagtgctg atattattca tccaggtcat ttgaatatca
     5041 ttcatgaggc ttcaaaattg gggcatgtaa cggttggtgt attaacagat tcagctattg
     5101 ccagttacaa gcgtttgcct tacttgaatt ttgatcagcg ctcattgata gttctgaatt
     5161 tgaagggtgt tgatgaagta atacctcaaa ctactcttga ttatgttccg aatttggaat
     5221 tgattaggcc taactttgta gtacatggtg atgactggaa agagggtatt caacaagaaa
     5281 ctcgccagcg tgtgattgat actatctcta aatggggtgg aaaagtgata gatgttcctt
     5341 atacgaaagg tatttcttcc actttattga atactaggtt gaaggaaata ggaaccactc
     5401 ccgaaattcg tttgaagcga cttaaacgct taattgctgc taaaagtatt gttcgtatct
     5461 gtgaatctca tagtgggtta acaggtttga taatagaaaa taccagtgta gaagtcaacg
     5521 gagttaagcg tgaatttgat gggatgtggt ccagtagtct tactgattcg acttctaaag
     5581 gtaagcctga tattgaagcc gttgacttga caactcgtct tcatgatttg aatgatgctt
     5641 tggagtgtac taccaaacca gtaatttttg atggtgatac aggtggtaaa atagaacatt
     5701 ttgtatttac tgttcgcacg ctggaacgtt tagggatatc agctgttatt atcgaggata
     5761 aaataggtct gaagaagaac tcgctttttg gaacagacgc tgttcagacc caggatacaa
     5821 ttgaagggtt ttgtgataaa attcaagcgg gtaaacgtgc tcagataacg gatgatttta
     5881 tgataatagc tcgtattgaa agttttattg ctggaaaagg tttagatgat gctttaggac
     5941 gtgcattagc atatattaaa gcaggtgcgg atgggattat gatccatagc aaagataagt
     6001 ctggtgagga tataaagaac ttctgtcttg ctttacgcaa aatacataaa tccattccga
     6061 tagtggttgt tccaactact tataaccata tatcagaaga tgaattggct tcttggggag
     6121 taaatgttgt aatatatgca aatcatatgc ttagaagtgc atatcccgct atgcttaata
     6181 cggcgaagtc cattcttgcc aatgcacgct cttatgaagc caatgactta tgcatgccta
     6241 ttaaagaaat tctggaattg attccaggga ctaagtaaat agactcttta aaattaaatt
     6301 cttattatta tgatttctcc taatattttt gtagactctc ttggcgctat gcagatggat
     6361 ttttttactg gagttcccga ttctttattg aagaatatat gtgcatattt aacagatcac
     6421 cttgcttctg aacataacat tattgccgct aatgaaggtg ctgctatagg tttggctaca
     6481 ggatattatt tggctacgag gaaaattcca gttgtttata tgcagaattc aggtcttgga
     6541 aatgcagtaa atcctttaat gtcattgacg gataaagaag tttataatat tccattgtta
     6601 ttgctaattg gttggcgtgg tgaacctggt gtgaaagatg agccacaaca tattaagcag
     6661 ggaaaagtca cacttccatt acttgaggca atgggtatca gatatgctgt tttatctcaa
     6721 gatgaaaaga agtttatatc tcaacttaat gttgcaaaat cttacatgga tgagacaaga
     6781 gagccttttg cttttgtaat tcagaaagac actttcttag agtatagttc tgaaaattgt
     6841 gaagatgaac ggttgtcttt gaaacgcgaa gctgctattc atttcatagc agcttcatta
     6901 acagaaaaag atattataat atcgacaaca ggtatgatat cacgtgaatt atttgaatat
     6961 cgtgaatcta cttctttaga acatgagaga gattttttga ctgtaggttc tatggggcac
     7021 gcgtcgcaga tagcattggg aatagctctt aaaaagagag actgtaaagt ttattgcttt
     7081 gatggagatg gttccacttt gatgcatatg ggttcgttag caattgtcgg ttctttacat
     7141 ccggaaaact atgtacacgt agtctttaat aatggcgctc acgattctgt ggggggacaa
     7201 ccaacagtcg ctttagatat tgatttatgt aaaattgctc aagcttgtgg ttatgaaata
     7261 gtattgtctg tttctgataa cgaaggttta tgtgaagctc ttaaaaagat acagcaaata
     7321 cgcggcccta ttttgttgga agtaaaggtt cgaaagggag ctcgtaagaa tttgggaaga
     7381 ccagccaaca ctcctataca aaataaagag gcattcatgc ttttcttaga taatttatag
     7441 agtaattatg gaacagcgtt tttttttagg agagtcttct ataaaagaat tgattcctat
     7501 cttgcaagaa tatactcctg atcatatatt tcttgtaaga ggaaaaaatt cttatgagaa
     7561 atgtggtgca caggctgtgt tagaatctgt ttttgttaaa ttagcttgtg gcgtgacgga
     7621 attctttgat tttgaagcaa atcctaaaat tgaagatatg gaaaaaggac tttcattatt
     7681 gaaagaatat ccgacaaata tgattattgc tataggtgga ggtagtgtat tagatatggc
     7741 aaaattgctt cgtttttttt attcctattc tggtaatcct acgggggggg agtttgaaaa
     7801 gaagcgacaa ttaattccat taataacact tcctactaca gctggtacag gtagtgaagc
     7861 aactcatttt tctgttttat ataaagataa agtaaaatat tcagtagaac atgatgctat
     7921 tcttccggat gtagcgattg tatatccaaa atttacttat ggaaattcaa aatatctaac
     7981 atcttgtaca ggctttgatg ctctagcgca ggcgatagaa gcttattgga atgtgaatgc
     8041 tacggaagag tcggataaat atgcggcgaa agcaattaaa ctcttatggc ctaatttgcc
     8101 attggttgta aattctccta cagcggaggc taggaataag gtttcggaag gctcttattg
     8161 ggctggtcgt gcaattaata taactaagac tacagctcca catgcttttt cgtattcatt
     8221 tacaactgat tatggatatc cgcatggaca tgcagtagca ttaacatttc ccttttttat
     8281 gagatataat attggaaatt cggatatctt attgaatcct aatataaatc cttacttata
     8341 taagattaaa atgcaaaaaa tgttacagtg gttaaatatg gaatgcgtag atgttgcaat
     8401 cgctatgaaa gagtatataa gaaacttggg attagatatt gacatatctc aaattgacat
     8461 atcgaaaatc gtatcttctg ttaatattca aagattaata aacaatccat ataaagttga
     8521 agcgatatgt ctagaggaat aagtgaaaag gagcaacgat ggttgttagt attatcacaa
     8581 gttattgaag ttcttgataa aaataattta ttatatttta ttgatactgg tactctttta
     8641 ggagctgtta gagataaaat gtttattcct tgggataatg atattgattt agcagttatt
     8701 ggaggagata catctactac taatttgctt aaagtgtcaa aattgttata tgctttaggc
     8761 ttttacgtca ctttgacaaa gaaagaaatt gctatctgtt ctagagacgg ggtaaattta
     8821 ggaattaaat tatataaaaa gcaagcaagt cattatgaag catgtatggg aaaagtttat
     8881 agacatagac tattttattc tataaattta tacctctctg gagaggtcct gtataaaaaa
     8941 ggcttttctt ttaagtataa agctatctca ctctttgtga agtttagtca agtctttaag
     9001 ttaaaattgt cttgtatttg gcaaatgaag ttattgtttt gggctaagta tgatgaaaag
     9061 acggtgatta ttccttttga gtttgtagat gcaattattg attataattt ttataatata
     9121 attgtgaaag tgccaaataa gccagaaaga tatctagcat atagatatgg tgaaaattgg
     9181 aaggttccca aacaagacta tgattatatg attgatgaca agtctattat aaatattgat
     9241 taaaaaaata tgaaaacaaa tttcaacata aggagtatta ttgtaattaa taaaattata
     9301 atcaactttt tctttagaca atatagatgg tatttataaa tagcactttc atttatacac
     9361 caaaattggg cacttatata ttatattctc ggaacaaatg aacattctaa taaattgctc
     9421 caatctcaag aaaggtggag ggcttcaagt cgctgattcg gtttgttctt gtttgaatac
     9481 aattccccaa catgattttt ttttagtatt atcctcatgt atggatgata ctgctgatag
     9541 ggtatcggaa tacaaaaatg tcactgtagt gcgtcatgat atacgaaaca gttggtatac
     9601 attgttttgg ggacgtgata aggctatgga taatttggta accagacaca atattggtgg
     9661 agttcttacc atattcggac ctgcaagatg gaagccgaaa tgtaagcatc tatgtggatt
     9721 tgccagatcc catctcgttt tgaacgattc tccctatttt caacgtatgt cttggaagga
     9781 actaatgata gaaaaggcga gaaatcttta tttatattat tacttcaaac gtggtgtgac
     9841 tgctttttgg actgagaatc cttatatttc agagaaagta aagcacttgt tccctaccat
     9901 aaaagcctat actgtatcga attattataa tcaggttttc gatgatgaaa atactcaaat
     9961 agaacatgcc ttaccgtctt ttgacggttg tactttactg tccataaatg ctccttatcc
    10021 tcataagaat ttagcaattg ctatcgaagt cgctcgatat cttaaaaaac attattccga
    10081 atttagtttt cgattcgttt ttacggtgac agagaatgac ttgccaccta ttccttctta
    10141 tttgcgagag catttctgtc tgattgataa agttagtgta gcagaatgcc cttccttata
    10201 tcgtcaggca gatataatgt ttcaaccaac tttacttgaa tgtttcactg ccacatatgt
    10261 cgaagcgatg cgaatgcaag tgccaatttt aactacagat ttgccatttg ctcatggatt
    10321 atgtggaaat gcagctgtgt actattcgcc gttagatgca gaagactgtg ccaaatcaat
    10381 ttataaaatg gctgtagaca catcctttca agattatctg gtcggagaag gaataaaaca
    10441 acttaagtcc ttcgataatt ataatcggag agcagaaaaa ttaatcgatt tgatatcgaa
    10501 tttggatgat taatacatat tatatttatg tcagtattta aagacaaagt cctccttata
    10561 accggaggta ccggcagttt tggtaacgct gtattgcgtc gtttccttga ttctgatatc
    10621 aaggagattc gtatttttag tcgtgacgag aaaaagcagg atgacatgcg tcatcacctg
    10681 caaaatccca aagtaaaatt ttacattggt aatgtccgtg accgccagtc tgtagacggt
    10741 gccatgatgg gagtggatta tgtgttttcc gccgccgctt tgaagcaggt tcccagctgc
    10801 gagttctttc cgttgcaggc tgtgcagacc aatgtgatcg gtacggacaa tgtactggaa
    10861 tccgccatag cgcatggggt gaaaaacgta gtagtgcttt ctaccgacaa ggcggcttac
    10921 cccatcaatg ccatgggtat cagcaaagcc atgatggaga aggttgccat agccaagggc
    10981 cgtgcgttgg gtgaggaagc cggtacaacc atctgctgta cccgttacgg caatgtgatg
    11041 gcaagccgcg gttctgtaat tcctttgtgg gtggagcaga taaagaacgg caggcccatt
    11101 acggtaacgg accccaacat gacccgcttc atgatgacgc tggacgatgc cgtagatctg
    11161 gtaatctatg cgtttgagca cgggcataac ggtgacctgt tcgtgcagaa ggctcctgcc
    11221 gccaccttgg atgtactggc gcaggccttg aaggaaacat acgcgcaggt tgatccgaaa
    11281 tacggtgaga cggaggtgaa gaccatcggt acgcgccacg gcgagaaact gtatgagaca
    11341 ctggtaaccc gcgaggagat ggcaaaggct gtcgacatgg gcgactacta ccgcattccc
    11401 tgcgacaccc gtgacctgaa ctatgacaag ttcttcacgg aaggcaatga ggatattgcc
    11461 cgtatagagg actatcacag ccataacacc gcccgcctgg atgtggaggg catgaaaaag
    11521 cttcttttga aactccgttt catccgcgaa gacctcggga tggaggaaaa ggcgaagagc
    11581 gcggaaatca agagtgaata agtctttaat ttgaataata caacaggaaa gaaagaggga
    11641 atgtattgtt cctttagaaa aaaaaactat ctttgccata ttgaaactaa taattgagaa
    11701 tatggcagca acagtattaa attcagttca acaacatctt ttgaagatgt ttgcttttga
    11761 tggttcggag gagcgattga atgaagttaa agaagtgttg accaaatatt tttctcagaa
    11821 gttagatgac cgcttgaatg acttatggga ttcgggagtt ttaaaccaag aaaaacttga
    11881 tgaactgaga aaaattgatg tccgtacact tccgaagaga tgaatagaat tgtattagat
    11941 acaaatagct tgatacagtg catttctccc aaaagcaggt accgtaagat ttgggattgc
    12001 tttttggatg gaacgaatca gttatgcgtt tctgatgaaa ttcttaatga atatgaggaa
    12061 atattagaac gtttggcagg tgtggaaata gctaagctgg tgattgatgt cattctcaat
    12121 aatccttata ctttgttctt tactccttat tataacttca atctgataaa atcagatccg
    12181 gatgataata agtttgtgga ctgtgcaatt gtggctaatg ccaagtttat tgttacggaa
    12241 gatcatcatt ttcatatatt gaagcaatat aatttcccaa aagtaagttt tataggtttg
    12301 gatgatttct gtcattcact atgaatatct tctcttttct gtgacaaaca gaacccatta
    12361 gtttatgaaa atcttagtaa ccggctcccg agggtttgtc ggccggaacc ttgtatccca
    12421 gctgcacaac atccgtgacg ggaaagcccg taattacggc attgcaggtg aggaacttac
    12481 tatttacgag tatgacatgg acagtgaccc tgccgaactg gatgtctatt gcagacaagc
    12541 tgactttgtc ttcaatctgg caggcgtgaa ccgtcccaag gatgcgtctg agtttatgaa
    12601 ggggaacttc ggcttcgcct ccacgctgct tgatacattg aagaagcacg gcaatacctg
    12661 tccggtaatg atttcctctt ccacgcaggc cgcactcgac aacccttacg gtgaatcgaa
    12721 acgggcaggg gagcaactgt tgttcgagta ctccagggaa acgggtgcaa aggtactggt
    12781 gtaccgcttc ccgaatgtgt tcggcaaatg gtgccgcccc aactataaca gcgcggtggc
    12841 cactttctgc aacaacatcg cccatgacca gcccatccgg gtgaacgacc cttcggtggt
    12901 gatgcatctg gtttacatag acgatgtggt ggacgaactt atttccgcct tgagcggtaa
    12961 ggaacaccgc aacggtgatt attgcgaagt gcccgtggtt cataccatta ccttgggcgg
    13021 cattgtggaa ctgataaggt ctttcaggca aatgcccggt accttgtccg tcccggattt
    13081 gagcgatgcc tttacaaaga aactctattc cacatacctc tcatacctgc ctgaagaacg
    13141 gttcagctat cccctgaaga tgaatgtgga cgaccgcggc agttttacgg agattatccg
    13201 tacttccgac cgcgggcagt tctcggtgaa catctccaag ccgggcgtta cgaaaggcca
    13261 gcactggcac cataccaaga acgagaagtt tgtggtggtg agcggacacg gtctgataca
    13321 gctccgcaag ataggtacgg aggaggttgt cagcttcgag gtaagcggcg ggaggatgga
    13381 ggtcgtggag atgattcccg gctatacgca caacattgtc aacctttcgg aaacggaaga
    13441 cctggtgacc ttcatgtggt gcaacgagtg tttcgacccg gcacgtccgg acacttattt
    13501 tgaaaaagtt tgaaacgagt taaagaatat aggaacagat gg
//
