LOCUS       c00181_gnlPro..        13580 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KKHFPLKO_181.
ACCESSION   c00181_gnlPro..
VERSION     c00181_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 16:59:49
            Original ID  :: gnl|Prokka|KKHFPLKO_181
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13580
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13580
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5551:11633]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5552..11633
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13580
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13580
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(55..1215)
                     /locus_tag="ctg181_1"
                     /transl_table=11
                     /translation="MEKITVPFITGDGVGAEVTPSMQAVVNAAVKKSYGDRRGIEWKEV
                     LAGERAFHETGSWLPDETMEAFRTYKVGIKGPLTTPVGGGIRSLNVALRQTLDLYVCQR
                     PVRWYKGIVSPLKEPQKVDMCVFRENTEDIYAGIEWEAGTPEAEKFYRFLRDDMGVTKV
                     RFPETSSFGVKPVSREGTERLVRAACQYALEHHLPSVTLVHKGNIMKFTEGGFKKWGYE
                     LAEREFGKELAEGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGG
                     IGIAPGANINYKTGHAIFEATHGTAPNIAGKDIVNPCSIILSAVMMLEYLGWKEAASLI
                     EKALEQSFTEARATADLARFMPGGVSLSTSAFTREIVGKIENGNNE"
     CDS             complement(1219..3462)
                     /locus_tag="ctg181_2"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGRE
                     EVAKMAASVAADLRADDEVLANPEKYYDRIIEIDLSLLEPYVNGPFTPDAATPISKFAE
                     VVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASPLIVNPGSEQIRA
                     TAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDDPERKNSIVTSFNRNFAKRADGNP
                     NTFAYVASPEITMALTIAGDLCFDPLRDTLVNAKGEVVKLSEPVGEELPAHGFIGGKEG
                     YIAPGKGQTEITVNPHSQRLQLLTPFPAWDGMDLLNMPLLIKVQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNKVWNRSTNTYGTVSGTAKLYKSEGIPSMVVAEE
                     NYGEGSSREHAAMEPRFLNVRAILAKSFARIHETNLKKQGMLALTFTDKADYDKIRERD
                     LISVMGLKDFASGRTLKVVLHHEDGSKESFEVQHTYNEQQIAWFRAGSALNAR"
     CDS             3658..5490
                     /locus_tag="ctg181_3"
                     /transl_table=11
                     /translation="MEYEYEKEEFKRQTENMGVARKVKRGLCWYPATPGRSYYNSLNQL
                     VIEITHTENTDIEHNFEFGRPVCFFRQSADGKITYMNFTATVSYADETRMVAIMPGAGA
                     VMEVQETDNLGVQLYFDETSYRTMFEALEDTLRSKGNRLAELRDILLGTSKAGFRELYP
                     VRFPWLNSTQETAVNKVLCARDVAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSN
                     TAVDWISEKLVDRGVNVLRIGNPTRVNDKMLSFTYERRFENHPLYPELWSIRKNLRELG
                     SRARRGSYDEREGVRSRMSRLRDRATALEIQINAELFDGAHVIASTLVSSNHRLLNGRR
                     FGTLFIDEAAQALEAACWIAIRKADRVVLAGDHCQLPPTIKCHEAARGGLERTLMEKVV
                     SNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGELEAAPEVRYRGILDWDTPIHWIDTSEM
                     DFKEEFVGETFGRINKAEADLLLSELKIYINRIGGNRILEEKIDIGIISPYKAQVQYLR
                     SKIKADASLKPYRSLFTVNTVDGFQGQERDVIFISLVRANEEGQIGFLNDLRRMNVAIT
                     RARMKLVILGEAETLKHHGFYRKLLEFIQNIGNQ"
     CDS             complement(5552..6595)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg181_4"
                     /sec_met_domain="IlvN (E-value: 3.9e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.5e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(6646..7398)
                     /locus_tag="ctg181_5"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(7395..7955)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg181_6"
                     /sec_met_domain="ALS_ss_C (E-value: 2.5e-19, bitscore:
                     58.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKLE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             complement(7988..9739)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg181_7"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(9831..11633)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg181_8"
                     /sec_met_domain="ILVD_EDD (E-value: 2.7e-219, bitscore:
                     718.4, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAARLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYASMVSSADKGAVGLID"
     CDS             12124..12696
                     /locus_tag="ctg181_9"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDVVVMDMNHPLAGCDLNFTGEVVESRPATNEELAEVARMM
                     GGGCGSCGCGDCGDGCGDHECGGGCCH"
     CDS             complement(12796..13578)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg181_10"
                     /sec_met_domain="SDH_alpha (E-value: 1.1e-62, bitscore:
                     201.4, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="TEAEEKALDLSLRKVYDFAMTTPLDEIRFILETARLNKAAAERSF
                     EGDYGHALGKILRGTYEHKIMGDSVFSHILSYTSGACDARMAGAMIPVMSNSGSGNQGI
                     SATLPVLVYAEENGKSEEEIIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGIT
                     WLMGGTYEQVAYAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAIMAMENRCVTS
                     VEGIIDEDVDQSIRNLTKIGSKGMNETDKLVLEIMTSK"
ORIGIN
        1 caaatcttcg gaaagcttgt aaatcagata ctccttcttc ataatcgttt cgttttattc
       61 gttattccca ttttctattt ttcctacaat ctcccgggtg aaagccgaag tggacagcga
      121 aacgccaccc ggcataaaac gggctaggtc ggcagtagca cgggcttcag tgaaactttg
      181 ctccaaagct ttctctataa gagaggccgc ttccttccag cccagatatt caagcatcat
      241 cacagcggaa aggatgatgg aacagggatt cacaatgtct ttcccggcaa tgttcggagc
      301 cgtcccgtga gtagcctcaa aaatggcatg ccccgtttta tagttgatat tcgcacccgg
      361 tgcaatgccg atgccgccta ccatggcagc cagttggtcg gacacataat caccgttcag
      421 attcaacgtg gcgatcacgg aatattcttc ggggataagc aacgtgttct gcaagaatgc
      481 atcggcaatg cagtccttga tgaccagacg cccttctgcc agttctttgc caaactcacg
      541 ttctgccagt tcgtaccccc acttcttgaa gccgccttcc gtaaatttca tgatgtttcc
      601 tttgtgtacc aatgtcacgg aaggcagatg atgctcaagc gcgtattggc aggcggcacg
      661 caccaagcgc tctgttcctt ctcttgaaac gggcttcacg ccaaacgagg aggtttcggg
      721 aaaacggact tttgtcaccc ccatgtcatc acggagaaaa cgatagaact tttcagcctc
      781 cggagttccg gcttcccatt cgatgcctgc ataaatatcc tcggtattct cacggaatac
      841 gcacatatcc accttctgtg gctctttgag tggagaaaca atgcccttat accaacgtac
      901 cggacgttgg cagacataca aatcgagcgt ctgacgcaag gctacgttca aggaacggat
      961 acctccgccg acgggagttg tcaaaggacc tttgatgccc accttatagg tgcggaaggc
     1021 ttccatggtt tcgtccggca accaggagcc ggtttcgtgg aaagcacgtt ctcctgccag
     1081 cacttctttc cattcaatgc cacgccggtc accataggat ttcttgacag cggcattcac
     1141 gacagcctgc atggatgggg tcacttctgc tcccactcca tcgccggtaa taaaaggtac
     1201 agtaattttt tccatattct atcttgcatt aagtgcagaa ccggcccgga accaggctat
     1261 ctgctgttcg ttatacgtat gttgtacttc aaaactttct ttactcccgt cctcgtgatg
     1321 aagaaccacc ttcaacgtac gtcccgaagc aaaatctttc aaccccatga cagaaatcag
     1381 gtcgcgttcc cgaatcttgt cataatcggc cttatccgta aaggtcagcg ccaacatgcc
     1441 ttgtttcttt aaattcgtct catggatacg ggcaaagctt ttcgccaaaa tggcgcgtac
     1501 attcaggaag cgtggttcca tggcagcatg ctcacggctg gaaccttcac cataattctc
     1561 ttcggcaacg accatggaag ggataccttc ggacttatac agcttcgcag tgcctgacac
     1621 tgttccatag gtattggtgg agcggttcca aaccttgttc gtctctccat tgaaagcatt
     1681 gacagccccc atcagcatat tgtccgaaat attctccaaa tgtccccgga aacggagcca
     1741 tggccccgcc atagagatgt ggtcggtggt acatttccct tgcactttaa tcaataaagg
     1801 catattcagc aagtccatgc catcccaggc agggaaggga gtcagcagtt gcaagcgctg
     1861 tgaatgagga ttgaccgtaa tttccgtctg tcctttgcct ggagcaatgt atccttcctt
     1921 tcctcctata aacccgtgtg ccggcagttc ttcaccgacc ggttcggaca gtttcacaac
     1981 ctctcctttg gcattgacca gcgtatccct caacgggtcg aaacaaaggt caccggcaat
     2041 ggtcagcgcc atcgttatct ccggggaagc gacgtaagca aaagtgttgg gatttccatc
     2101 ggcacgtttg gcaaaattac ggttaaaaga ggtgacgatg gaatttttgc gttcggggtc
     2161 atcagtatgg cgcttccact ggccaataca aggtccgcag gcattcgcca ttatcgttgc
     2221 gccaatatct tcgaaagcgg caatcatgcc gtcgcgttca gcagtggcac gtatctgctc
     2281 cgaaccgggg ttgacaatca gcggagaagc aaccttcaaa ttcttttcct ttacctgccg
     2341 ggcaagggag gccgcgcggc tcaaatcctg ataggacgaa ttggtgcacg accctatcag
     2401 gccgacttcc atccggcggg gatagttatt ggttatcact acctcggcaa atttcgatat
     2461 cggtgttgct gcatccggcg taaagggccc attgacatac ggttccaaca gcgagaggtc
     2521 tatttcaatg atgcggtcgt aatatttttc cggatttgcc agcacttcgt cgtcggcgcg
     2581 aaggtcggca gctacggaag cagccatttt tgccacttct tcacgtccgg tagccttcaa
     2641 gtaggtaccc atacgctcat cgtaagggaa aagggaggta gtcgccccca cctctgcccc
     2701 catattgcag atggtagcct ttccagtggc agacaatgaa gcggttcccg gtccgaaata
     2761 ttcaatgatg gcattggttc ccccttttac agtaagaata cccgccaact tcagaataac
     2821 atctttggga gctacccagc cactcaattt acccttcaag tgtacgccta tcagacgcgg
     2881 cattttcagt tcccattcca tgccggtcat cacatccacc gcatcggcac cacccacacc
     2941 aatggccacc atgcccaaac ctccggcatt gggcgtatga gagtccgtgc ctaccatcat
     3001 tccacccgga aatgcgtagt tctccaatac cacctggtga ataatgcctg ctcccggctg
     3061 ccaaaaacct atgccatagc gggaagaaac atcacggaga aaattataga cctcctcatt
     3121 ggtcttcgta gcagtcgcga tatcttcttt tgcaccttta tatgcttgaa tcaaatggtc
     3181 acagtgcaca gtggaaggca cggcaacctg ctcacggcct gcattcataa attgcaataa
     3241 ggccatttga gccgttgcat cctgcatggc cacacggtcg ggacggaaat tcacatagtc
     3301 ttctccccgt ctgtagttct tcactttatc cccatcatac aaatgagcat acaaaatttt
     3361 ctctgctaaa gtcatcggac gccgcagtac gttccgtacg cgttctatct tctccgaata
     3421 agcggcataa aacgttttga gcatcgttaa atcatatacc ataaccacta ttttttagtt
     3481 tttcattatt gtaaagatta caaattaata tcataaacaa ataaaaaggc tgaatagttt
     3541 aacaaaataa agcatttttt ccgtcggaag cgaagaatga ttacctttgc aaccatgaag
     3601 gaacaagatt caaatagtcc tattattcac ctccagcaac aacaactttt gctgcgcatg
     3661 gaatacgaat acgaaaaaga ggaattcaaa cgccaaaccg aaaacatggg ggttgcccgg
     3721 aaagtgaaac ggggactttg ctggtatcct gccactccgg gacgaagtta ctataattca
     3781 ctgaatcaat tagtaataga aattacacac acagaaaata ccgatataga acataatttt
     3841 gagttcggcc gtcccgtatg ttttttccgc cagtctgccg atggaaaaat aacctatatg
     3901 aacttcaccg ctaccgtaag ctatgccgac gagacacgga tggtagcgat aatgcccgga
     3961 gccggtgccg tgatggaagt gcaggaaacg gacaacctcg gcgtgcaact ttatttcgac
     4021 gaaacatcct atcggaccat gttcgaagcc ttggaagata cgttacgctc caaaggcaac
     4081 cgcctggccg aattgcggga catattgctg ggaacctcga aagccggttt ccgagagctc
     4141 tatcccgtac ggtttccctg gctgaactcc acgcaggaga cagctgtaaa caaagtgctg
     4201 tgtgcccgcg acgtggccat tgtacacggt cctccgggaa ccggaaaaac gaccacctta
     4261 gtggaagcca tctacgaaac cctgcatcgg gaaccgcagg tactggtatg tgcccaaagc
     4321 aatactgccg tcgactggat ttcggaaaaa cttgtggacc gtggcgtcaa tgtcctgcgt
     4381 atcggcaatc cgacccgtgt caacgacaag atgctttcct ttacctacga gcgtcgtttc
     4441 gagaaccatc cgctttatcc ggagctgtgg agcatccgga aaaatctccg tgaactgggc
     4501 agccgtgccc gccgtggcag ctatgacgaa cgcgaaggag tacgcagccg tatgagccgc
     4561 ctgcgcgacc gcgccaccgc attggaaata caaatcaatg cagagctttt tgatggggca
     4621 cacgtcatag cctccacgct ggtaagcagc aatcaccggc tgctgaacgg acgccgtttc
     4681 ggcacccttt tcattgatga agcagcccag gccttagagg ctgcctgctg gatagctatc
     4741 cgaaaagcag accgcgtggt attggcgggt gaccactgcc aacttccgcc caccataaaa
     4801 tgccacgaag ccgcccgtgg aggtctggaa cgaacattga tggagaaagt ggtgtccaac
     4861 aaacctgccg ttgtctcttt gctgaaagtg caataccgca tgcacgagga aatcatgaaa
     4921 tttccttccc aatggtttta taatggcgag ttggaagccg ctcccgaagt gcgttaccgg
     4981 ggcatcctgg actgggatac ccccatccac tggattgaca cctccgaaat ggatttcaaa
     5041 gaagaatttg tgggagagac tttcggacgc attaataagg cggaagcgga cctgctccta
     5101 tcagaactga aaatctacat caaccgtatc ggtggcaacc gcattctgga agaaaaaata
     5161 gacatcggca tcatctcccc ttacaaggca caagtgcaat atctccgcag caagataaag
     5221 gcagacgctt cactcaagcc ttatcgcagc ttgttcactg taaatacggt ggatggcttc
     5281 caagggcaag agcgcgatgt tatcttcatc agccttgtcc gtgccaacga agaaggacag
     5341 ataggattcc tgaatgattt aaggagaatg aatgtagcca tcacccgggc acgtatgaag
     5401 ctggtgatat tgggagaggc agagacgctg aaacatcacg gtttttaccg gaagctattg
     5461 gagtttattc aaaatatagg gaatcaataa taaagaaata ccccctccgg taacaccgaa
     5521 gagggtattt cacctattta tataaagctg attaattgtt ttccggacga agtttacgaa
     5581 ctgtaacagc tgtctgccac atttcgcttt cacgcaaggc tttcaattct gcattcagct
     5641 tctcacgata atcgggtttg gagttactgt cgatagaaat ctgggcttcg ttgcccgact
     5701 tcacacttgc atacaatttc tgtacaaccg gcttgatggc atcatggaac ggggtcatcc
     5761 aatccagcgc accacgctgt gccgtagtag aacagttggc atacatccag tccataccgt
     5821 tcttggcaaa caatggcatc aaagattgag tcaactcttc cactgtttca ttgaatgctt
     5881 cagaaggagt atggccgttt tcgcgcaata cttcatactg agccaacagc aatccctgga
     5941 tagcacccat caatgaaccg cgttcaccgg tcaagtcgga agtggcttcg cggatgaaag
     6001 ttgtctcgaa caaatatccc gaaccgatac cgatacccag tgcaatcgtc ttgtcaaaag
     6061 ccttacccgt agcatcttga tagacggcat atgatgagtt caagccacgc ccttcgagga
     6121 acatggtacg aagtgaagta ccggaacctt tgggagcaac cataataaca tcaatatctt
     6181 taggaggaac cacgccggta cggtcgttcc aggtaatagc aaaaccatga gagaagtaaa
     6241 gagcctttcc gggagtcaaa taaggtttga tagtcggcca tacagacatt acagctgcgt
     6301 cagacaacag acacatgacg atagtacctt tctgacaagc ctcttcgatg ccgaacaaag
     6361 tctcacccgg tacccatccg tcagccacag ccttttcgta tgtcttaccc ggacgttgtc
     6421 ctacaatcac attgaaaccg ttatcacgca agttgcaagc ctggcccggg ccttgtacgc
     6481 cataaccgat tactgcaatt gtttcatctt tcaaaatctc acgtgctttt tccaaaggaa
     6541 attcttcgcg ggtcattaca ttctcaataa caccgccaaa attcaattgt gccatttttt
     6601 gttttaattt ttatttgtgg cttacgccaa cgttgataaa tttatttatt tctctgtaaa
     6661 tatcacttta gagcgacaga ccacttcgct gccattcttt ttcacctcca catcgtaaac
     6721 gccctcaccg gcatcatcca tgaacaaagt caactcatcc ccataatagc tttcggctac
     6781 atatgccatt tcaaaacgac ggatgcgctt ctccttatac atctctatcg ggaacaaatc
     6841 aaggatatgc tcgatgtaac ggatgctgtt cacatgcccg ttaatgtcaa tatcactgta
     6901 tttggctacc aaagcagcaa ccggttcctt tgaggccacc tttatccgcg aaggtttttc
     6961 tatcgggcaa ggctcatcgc aaacataatc tacaatgctg ccactatgaa gagccagcaa
     7021 atctgccggc ttacgggtat tcatgctaat catcgcccaa acggaacgtg catacccaat
     7081 cttcttaccc tccttatcga tgatagcgaa attacggtct gtaaaaaggc gatagacatt
     7141 ctccacccaa gtctgaatgg agaaatcttc gtactgataa ggcatttcat ccagttcgac
     7201 agccagacgg gacaataccc aagtataatt gtcctcgttt agagtcgcga tgccaaaacc
     7261 gcggtcgctg gcatggaaac ccgcacaatt caacaaatgg ttgcccaata ctcccattgt
     7321 cagccgtccg gtaaagtcga catgaaacgg ttcggcaaca aacttgtagg tacctatttt
     7381 attgttctcg ctcatcatga ttcctggtgt ttactttgac gatattttgc ttcacggtcc
     7441 gccagatatt cattgacacg ctcaaagcag ctggtcgtaa tggctacgcg acccgaacgg
     7501 acgaactgaa gtacgcaatc caactggcgc aactcctcat aaagattggt tatttcctca
     7561 ctcatgccat tcttctcaac aatggcaaat acagcattca cctccacaat acgggcattg
     7621 tacttacgga ttactttgga cacctccagt ttttcttcca gcgtaggggt cgttatttta
     7681 taaagggcaa tctcgtgctg atagatttca tcatccgtga aataatgggc ttgcagcaca
     7741 tctattttct tggtaatctg cttggtcacc ttttcaatgg tatccttatc cgtccaagcg
     7801 gtaatggtat atttatgtac ccccttgatg gaggaggccg atacattcaa actctcgatg
     7861 tttatctgcc ggcgggtaaa cacagccgtc acctgattca gcaaaccggc aaagttttcc
     7921 gaatgaacaa tgattgtata tagtttttta tccatagata gagtaaattc tttaatttcg
     7981 catgacttca gcattccaac aacatctgat tgaccgaacc gcccggaggt gtcatcggca
     8041 ttacatttcc ttcttcctcc acacaagctt cgagcaggaa cggtccgtca gtcgctatca
     8101 tctcgtcaat cgcttttgcc agctcctcgc gggtcattac cctgcgtgca ggaatatcat
     8161 atgccgaagc aatcttcata taatccggat tcatcatcgg agtaaacgaa taacgacgat
     8221 tgaagaacat cgcctgccat tgacgaacat tgcccaggaa gttattgttc aacagaatca
     8281 tcttcaccgg agccttttgt tccatgatgg tacccagttc ctgcaggttc atctgcaagc
     8341 cgccgtctcc catgaatacg cataccgtgc ggtccggacg tccaaaagtg gcaccgatag
     8401 ctgccggaag gccgaagccc atagtaccca ggccaccgga agtaacaatg ctacgttcct
     8461 tgctgtattt gaaataacgg gcggacatca tctgattctg gccgacatca gtcaccaata
     8521 tcgcctcgtt atgggtagcc tcactcacag cacgcaccac ctcacccatg cttagcgctt
     8581 ttcctgccgg atgtaattcc ggacggatta ccttttcctc ttccacttcc tcgtattgcc
     8641 ggaaactgtc aatccattcc tgatggttgg cgggttccag caattgggta acggcagcca
     8701 gtgtctcttt gcaatctccc aggacagcaa catcggtctt tacattctta tctatttcgg
     8761 cagggtcaat atcaaagtgg ataatcttcg cctgcttggc atatgtttcc aatttacccg
     8821 tcacacggtc atcaaagcgc atgcctacgg cgataaggac atcacattta ttggtattga
     8881 tattgggccc caggttaccg tgcataccaa gcattccttt gttcaacgga tggttcgtag
     8941 gtaatgcgga aagtcccaat aaagtgcatc cggcaggcat tccggctttc tcaatgaaag
     9001 cacgaagctc ttgctgggct tctcccagct ccacgccttg tcctaccagc accaaaggcc
     9061 gttccgcacc atttattaat tcagcagcct tccgtatggc ctccggctcc atttcgggaa
     9121 cgggaagata gctacggaca tagtccacct tagtaggcgc atattctgtt ttctccactt
     9181 gggcgttttt agcaaaatcc agcacgaccg gtcccggacg tccgctcttt gccacataga
     9241 aagcacgtgc cactgcccag gccacatctt ctgcacgacg aatctggtaa ctccatttcg
     9301 tgataggctg agtaatgcct accaagtcca cttcctgaaa tgcatccgta cccaagaagt
     9361 tcgtccctac ctggccggca atgacaacga taggcgtact gtcaatcatg gcatctgcaa
     9421 tgcccgtgat agtattggta gcacccggtc cactggtaac cagacaaacg ccaacctcgc
     9481 ctgatacacg tgcaaagcct tgtgccgcat gggttgctcc ttgttcatga cgaaccaaga
     9541 tgtggttcaa ttccttccga tggtcgtata aggcatcgaa taccggcatg atgctccctc
     9601 ccggataacc gaaaatagtc tttactccct gatgctccag agagcgcatc aatgcttctg
     9661 cgcctgttat tagagcctca ccccgaccct ctccttggga gagggaggaa aagttactct
     9721 ttttattatt atcagccata ctttatctat tcattatatt taaaagctca atagtagctt
     9781 gaaaaatttg tttcattctc tcctcccctc gctttcggaa aggggggctt ttaatcaatc
     9841 agccccacag cccctttgtc agcggaactc accatactgg catatgcttt caatgctttg
     9901 gagacttcac ggttgcgggt taccggagtc atagggcgtg ctgcaagctc ttcatccgtc
     9961 aacttcacat tgatagaacg gttcggtata tcaatttcga taatgtcccc atccttaatc
    10021 ttgccgatat taccaccggc agccgcttcg ggagaaacat gtccgatact tagtccggaa
    10081 gtaccaccac tgaaacgccc gtcggtaatc aatgcacact ccttacccag atggcgggat
    10141 ttgatataag aagtaggata aagcatctct tgcatacccg gtccaccttt cggcccttcg
    10201 tgagtgatga cgacgacgtc tccactgacc acctttccac ccagaatacc gtcgcaagcc
    10261 gcatcttgtg agtcgaagac tttcgccggc cccgtaaatt tccagatact ctcgtctaca
    10321 ccggcagtct tgacaacgca accgtcctga gctatatttc ccttcaaaac cgccagaccg
    10381 ccatccttgc tgtatgcatg ttccaaatca cggatacaac cagtcgcacg gtccgtatcg
    10441 agttccttat aagacgcatt ttgtgagccg agtaccagat tgaactttcc ggctgccgca
    10501 ctggagtatt tcttgattgc ctctttacat acattagagc tggtaatact ataccggtcg
    10561 attgcctctg ccaacgtcat tccatccaca cggcggacat tcgtatcgac caatccgccc
    10621 ttggcaagct catccatgat ggcaatgatg ccaccggcac ggttaacgtc ttgtacatga
    10681 tacttttggg tattgggagc caccttgcat aagcaggggg tcttgcggga gagcatgtca
    10741 atgtcgtcca tcttaaaatc cgctccggct tcgtgagcca cagccagcaa atgaagtacc
    10801 gtattagtag aaccgcccat cgcaatatcc agcgtcatgg cattcaaaaa tgcctcgcgg
    10861 gtagcaatac tgcgcgggag tacactctca tccccttctt cataatatct aaaggcattc
    10921 tctacaatca acctggctgc atcctcaaat agtttcttgc gattttcgtg agtggctaca
    10981 atcgtgccgt taccgggcag tgccaatcca atcgcttcat tcaagcaatt catggaatta
    11041 gcggtaaaca tgcctgagca gcatccgcaa gtggggcagg catgttgctc aatctgtgcc
    11101 acctctttat cgcccacact ttcatcagca gatttaatca tggcatcaat caaatccaaa
    11161 tgctgtccgt tccattcccc ggcttccatc ggaccgcctg aaacaaacac agtcggtata
    11221 ttcagcctca tagccgccat cagcatcccc ggagtaatct tgtcacagtt actgatgcaa
    11281 accatagcat ctgccttatg ggcatttacc atatactcca cactatcggc aatgatatct
    11341 cttgaaggca gggaataaag cataccgtcg tgtcccatag cgataccgtc gtcaatggca
    11401 atcgtattga actccgcagc aaaacacccc agtttttcaa tctcttcctt tacaaactgg
    11461 cctatttcgt gcagatgtac atgcccgggg acgaattgtg taaatgaatt gactatagcg
    11521 ataatgggct tacccatctg ttctttcttc ataccattcg ccgtccacaa tgcacgggct
    11581 cccgccatgc ggcgaccttg tgtgctgaac gagctgcgta actgatgctt cattttcaaa
    11641 tctcctttta atgaaaaagc ctctcccact atagtgagaa aggcttaata aattatcttc
    11701 taacgtacga atacatacat aacctttctc acgctcttga tgccaccacc acgacgcgaa
    11761 taatatgcag gactgccagg ttaatagatg tatgtaaatt cataacttaa ttcttctttt
    11821 ttgtttcaaa cgtgctgcaa aggtaagggc ttttttataa tctccaaaca aattgaagaa
    11881 aaaaataaga taaatatgaa taatcgtaag aaaatatcgc cctaaaatcc tattttatca
    11941 cttaacagtt ctaaatagca ccattcagac agccaatgta aatgtattgc caatcattga
    12001 aaccatttaa taatctgaaa attaccaaag gctctctaca tcccgaaaca aataattcgt
    12061 atctttgtct cttcaaatac tcaaaaaaac agtatttact aattaaataa agatagaaaa
    12121 ttaatggaaa cagtagaaaa caagtacatc accgtagcat ataagctgta ctcaatcgaa
    12181 aacggagaaa aagatttcga agaagaagca cccgtagagc atccttttca gtttatctca
    12241 ggtctgggaa tgacactcga accctttgaa gcccagataa aagacttgca gataggcgat
    12301 aaattcgact ttaccattcc ggcatcagaa gcttatggtg aatatgacga cgaccatgtc
    12361 attgacctcc ccaaagaaat cttcatgata gaaggagaat tcgacagcga ccgtgtagtg
    12421 gaaggcgccg tcatcccctt gatgacttct gaaggtcaac gcatcaatgg aagtgtagta
    12481 gaagtaaagg aagacgtggt tgtaatggac atgaatcatc cactcgcagg ttgtgatttg
    12541 aactttaccg gagaagtggt ggagagccgt ccggctacga acgaagagct tgctgaagtt
    12601 gcccgtatga tgggtggcgg ttgcggcagc tgcggttgtg gtgattgtgg cgacggatgc
    12661 ggcgaccatg aatgtggagg cggatgctgc cactaaagaa ttaagaatta aaaattaaag
    12721 aatcagacta cacagtatta agcatgccgc atggtaattc tttaattttt aattctttaa
    12781 ttttcaaatt ctatattatt tacttgtcat tatctccaat accaatttat ccgtttcatt
    12841 cattccttta gaaccgattt ttgtcagatt acggatactc tgatccacat cctcatcaat
    12901 aataccttct acggaagtca cacaacggtt ttccatggcc atgatggctg aaagcactgc
    12961 ggttgaaact ccggtagtta ctttcaatgc acaactgggt ttggcaccat cacaaatcat
    13021 tccggtaaga ttggcaatca tgttctgcac agcatatgcc acttgttcat aagttcctcc
    13081 cattagccag gttataccgc aactggaacc cgtggcagca accacacaac cgcataaggc
    13141 agataagcgt cccaaactct gcttgatata gattactgtt aaatggctca acatcaaagc
    13201 acggataatt tcctcctcgg attttccgtt ctcttctgca taaacaagta ccggcaaagt
    13261 agctgaaata ccttggttac cactgcctga attactcatt accggaatca tggcacctgc
    13321 catacgagca tcgcatgcac cagaggtata agataatata tgagaaaaca cactatcccc
    13381 cataatttta tgttcatagg taccacgaag tattttcccc aaagcatgac cgtaatcacc
    13441 ctcaaaagaa cgctcggccg cagccttatt caaacgggct gtctcgagaa tgaatcgaat
    13501 ctcgtccaac ggagtggtca ttgcaaaatc atagacttta cgtaaagaca aatcaagagc
    13561 tttctcctct gcttctgtag
//
