LOCUS       c00371_gnlPro..        16412 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KKHFPLKO_371.
ACCESSION   c00371_gnlPro..
VERSION     c00371_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 16:59:49
            Original ID  :: gnl|Prokka|KKHFPLKO_371
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 9542
            Orig. end    :: 25954
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16412
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[19542:24252]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14710
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16412
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16412
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             773..877
                     /locus_tag="ctg371_13"
                     /transl_table=11
                     /translation="MTYKCPVKPNDSELKGTNVKSTQGFPATVSVSIR"
     CDS             1063..1566
                     /locus_tag="ctg371_14"
                     /transl_table=11
                     /translation="MRRLAVIVCGKQLTVGDGQYRPAGNGRGIDIIRQKLELTVKPLLL
                     LQAVEVIDGKSHLFIAVTFPEVAFVGRVVIPMLYHLAYKLHCGIILFLIPFTFRLHHHL
                     IQCISGWRKGYIELRRLCRMNQPDIFIISHGRNDQRGLRAIGLEGKTAVIVRHPSLRSS
                     FQIN"
     CDS             1875..3569
                     /locus_tag="ctg371_15"
                     /transl_table=11
                     /translation="MEWIFNQLRERPELAIFLTIFLGFWLGKLRIGKFTLGTVTSVLLV
                     GVLVGQLNIAVPGPIKSVFFLLFLFAVGYKVGPQFFRGLKKDGLPQVGFAVLMCISVLL
                     VTWLLALMMGYNAGEAAGLLAGSQTISAVIGVAEDTMANMGLDEAQRQSYVNIIPVSYA
                     VTYIFGTAGSAWVLSSIGPKMLGGLEKVKAACKELEAKMGSSLADEPGFMPAARPVTFR
                     AYRVENEWFKNGKRVIDLEVYFRQHDKRLFVERLRKSGIVVEVSMNLRIEPGDEVVLSG
                     RREYIIGEESWIGPEVQDAQLLDFPAEKLPITITRKTVAGKTVAAIRREKFMHGVSIRS
                     IKRAGISIPVLAQTVVDAGDVIEVVGTRQEVEAAAKRLGYIDRPTNQTDMIFVGLGILV
                     GGLFGALSVHIGGIPISLSTSGGALIAGLLFGWLRSKHPTFGRIPEPSQWVLNNVGLNM
                     FIAVVGISAGPSFVQGFHDVGISLFLVGAAATTLPLIIGLLLARYVFKFHPALALGVCA
                     GARTTTAALGAVQDAVESETPALGYTVTYAVGNTLLIIWGVVIVLLI"
     CDS             3846..5480
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GlcNAc_2-epim"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg371_16"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.5e-22, bitscore:
                     70.9, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="GlcNAc_2-epim (E-value: 0.0004, bitscore:
                     10.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTKLLEKKMESISPFELKNRLIDMADESLKKTARTMLNAGRGNP
                     NWIATAPREAFFLLGSFGLEECRRIMDLPEGIAGIPEKKGIASHFEAFLKKNNNVPGAK
                     LLEQTYNYLLMQHAADPDSLVHEWAESIVGDQYPVPDRILHFTEILVQDYLSQEMCDNR
                     PPRGAYDLFATEGGTAAMCYIFDSLQENFLLNKGDGIVLMVPAFTPYIEIPQLSRYQFR
                     VTKIHANRMNNEGMHLWQYSDEDIDRLKSPKIKALFVTNPSNPPSYTLSPDTMARIVSI
                     VRNDNPNLMIITDDVYGTFSPHFRSFMAEIPYNTLCVYSFSKYFGATGWRNAVIALHEF
                     NLFDKLIAKLPKEKREILHHRYSTLTLEPEKLKFIDRMVADSRQVALNHTAGLSLPQQM
                     QMGLFAAFALLDKENKYKQKMQEIIRRRLHALWENTGFTLTEDPLRVGYYTEIDMLVWA
                     KKFYGDDFVEYLKRTYSPLNVVFRLAKETSLVLLNGGGFDGPEWSVRASLANLDEKDYA
                     TIGQGIKKILEEYAKEFFKNGKAKGKN"
     CDS             complement(5514..6827)
                     /locus_tag="ctg371_17"
                     /transl_table=11
                     /translation="VRIKFFFFILVLFLLGLGGMLVYLLSGKPSLYLYVLEGLIGFILI
                     YLIVFYNKIVKPMNTIGSGMELLREQDFSSRLSRVGQYEADRIVNIFNRMMEQLKNERL
                     RMREQNHFLDLLIQASPMGVIILTMDDEVSQLNPMAVKMLGVRMEEAMAKRLDQMDSPL
                     AAELSSIPKDETAVVRLNDANIYKCTHSSFIDRGFKHPFFLIERMTEEVMRAEKRAYEK
                     VIRMIAHEVNNTTAGITSTLDTVEQALSTEDDMEDICDVMRVCTERCFSMSRFITRFAD
                     VVKIPEPTLAPVQLNELVSMCKRFMEGMCNDRNIELRLECDSEVGMVRMDASLFEQVLV
                     NIIKNAAESIEGDAGENGQQGEIIVRTTAPASVEVVDNGPGISKETEAKLFSPFFSTKP
                     NGQGIGLVFIREVLSRHGCTFSLRTYNDGLTRFRILFN"
     CDS             complement(6818..8179)
                     /locus_tag="ctg371_18"
                     /transl_table=11
                     /translation="MILIIDDDSAVRSSLSFMLKRAGYEVKTAPGPREAMDIVRAEAPA
                     LILMDMNFTLSTTGEEGLTLLKQVKVFRPDVPVILMTAWGSIQLAVQGMQAGAFDFITK
                     PWNNAALLQRIETALELTAAPKEVPEEQTTALNRSHIIGKSKGLMEVLNTVARIARTNA
                     SVLITGESGTGKELIAEAIHINSQRVKQPFVKVNLGGISQSLFESEMFGHKKGAFTDAS
                     ADRIGRFEMANKGTIFLDEIGDLDPSCQVKLLRVLQDQTFEVLGDSRPRKVDVRVVSAT
                     NADLRKMVSERTFREDLFYRINLITVKLPSLRERREDIPLLARHFADRQAEVNGLPRTD
                     FSADALNFLSRLPYPGNIRELKNLVERTILVSGKPVLDATDFDAQYLRHDEPAKAAEGT
                     SFAGMTLDEIERQTILQALEQHKGNLSQVAVSLGISRAALYRRLEKYNIQVPCA"
     CDS             complement(8323..9681)
                     /locus_tag="ctg371_19"
                     /transl_table=11
                     /translation="VDAAVALNELKTAYWEYRTFRADLLPEVNFTGTLPNYNKSYSTYQ
                     NSDGSYSFVRNNTLGLSGQLSVDQNIWFTGGKLSLTSSLDYLKQLGSGGAKQFMSVPVS
                     LELTQPVFGVNTLKWNRRIEPVRYAEAKAEFISATEEVTMKTITYFFELLLAKESLATA
                     MQNKTNADRLYEVAIAKRKMGQISENDLLQLKLNSLQGKADVTEAESNLNAKMFQLRSF
                     LGVSEQESLNPVLPATVPDIKMEYDRVLNKALERNSFAQNIRRRQLEADYEVATARGNL
                     RSIDLFASVGYTGQNHEFSSAYRDLLDNQIVQVGVKIPILDWGKRRGKVRVAKSNREVV
                     LSRIRQEQMDFNQDIFLLVANFNNQAQQLDIAEEADVIAEKRYKTSVETFMIGKISTLD
                     LNDAQNSKDEARQKHISELYYYWYYFYQLRSLTLWDFERDTELEADFEEVVRG"
     CDS             10001..10516
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg371_20"
                     /sec_met_domain="Glyoxalase_4 (E-value: 8.2e-26, bitscore:
                     81.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LMKNFFIKEEFSFFVLLYTFIKKDTILTLIYIVMKISHIEHLGIA
                     VKSIEEALPYYENVLGLKCYNIETVEDQKVRTAFLKVGDVKIELLEPTSPESTIAKFIE
                     KNNGNGGMHHLAFAVEDGVAGALAEVEEKGIRLIDKAPRKGAEGLNIAFLHPKSTLGVL
                     TELCEKPE"
     CDS             10573..12126
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg371_21"
                     /sec_met_domain="CT_Btheta (E-value: 2.6e-291, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             12545..13090
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg371_22"
                     /sec_met_domain="OAD_gamma (E-value: 7.2e-18, bitscore:
                     55.8, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LYDSGKKLLDQVIVPAGTLKANQSYARVSDAADQWEVKGGSEDKY
                     VTPSTNNKTIDSNAKMEKFEEHDSVGIGMAISAMSVVFCGLILLYISFKIIGKISVNLS
                     KRNAMKAKGITDKQEAKEKQLGQAPGEVFAAISMAMHEFQSDVHDVEDTILTITRVKRS
                     YSPWSSKIYTLRETPHKK"
     CDS             13114..13548
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.3; E-value:
                     2.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg371_23"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.1e-21, bitscore:
                     67.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNIYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKVV
                     VKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPLPGVILDIKVNVGDTVKKGQVII
                     ILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLVIIE"
     CDS             13634..14710
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg371_24"
                     /sec_met_domain="OAD_beta (E-value: 3.3e-152, bitscore:
                     497.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VVMLLVGLFFIYLAVAKEFEPMLLIPIGFGMLIGNIPFNMEAGLK
                     VGIYEEGSVLNILYQGVTSGWYPPLIFLGIGAMTDFSALISNPKLMLVGAAAQFGIFGA
                     YMIALAIGFDPMQAGAIGIIGGADGPTAIFLSSKLAPNLMGAIAVSAYSYMALVPVIQP
                     PIMRWLTSKNERLIRMKPPRVVSHTEKVMFPIIGLLLTTFLVPSGLPLLGMLFFGNLLK
                     ESGVTRRLANTASGPLIDTITILLGLTVGASTQASEFLTLDSIKIFGLGALSFVIATAS
                     GVIFVKIFNLFLKKGNKINPLIGNAGVSAVPDSARISQVVGLEYDPTNYLLMHAMGPNV
                     AGVIGSAVAAGILLGFLM"
     CDS             14964..16232
                     /locus_tag="ctg371_25"
                     /transl_table=11
                     /translation="MANYDYETALMLIDQETPTVPLLYQKGKALKGLGNNLEALSVFQE
                     VVAQDSLNPRAYIEAAECCKSLAKYSEALDYYQNALHINPDNKYARIQYISLLMNMKRY
                     RESLKESNLLAERDSSAYVLHLRAESMGQVYDNTEIMHVIDAYLDIQKRYPNDYLSAAK
                     LGNIYVAGHQYEDAINITEKYRSIDSTNVLVNRINAQAYCLNKDYPKAIERYEQLLQEK
                     DSSFQTCFYAGISYYALEDFYPAHDLLERALKDDNTNINVLYYLGRACSKTSWKEDGVT
                     YLETAVSLAMPSDSVMSRLYVGLADCYKMAFQYTDQANTLLTQYEKYDRQKHKLLYDAA
                     FIYYYYLKDASKAERYLTAYLKTRPKNSKDKVQEVDADGVPIIGEDNRYNAAENWLKDI
                     REKRKKEDFFKGKVDTASVTPIK"
ORIGIN
        1 tttcaaagca agaaaaacat tgtcctgact ggtataaaga tagtgttgtc catattgatt
       61 gacatctgac aagtaacgga gcttcaacga atgtatagga aattcattgg catattcctt
      121 cttcttatga aaagaatatt ccagttcggc aagtcctttt acacgatggt cgcgaaaacc
      181 gtatgccata taccccctac cgaacagatg cggattgagc catgccgtcg tcataccgcc
      241 ggcacgcaag cgcacccctt ccagtgtatt tccgctgatg gtggtattca tcataccgat
      301 atagaacaaa ggttcttttt ccttcggagc gggaatatac cccgtgaaca gcaccttcaa
      361 cactttctcc gtccagaaat aaacgggata gctgcgcaac tgggccatca tcttgtccac
      421 cgaagtctct ttcttgctga cctccacctg gcggttggca tcccaatatg cttccgaata
      481 gccggaagcc gatgtctctt caatcacctt ttccggtttt cggaaagcct gcagagcctt
      541 gtcatccggt tcatactgat aatttctgta atacacatcc cgcttggcat aaataccgtc
      601 actattgtcc accaacttga actccgtagt gatactctca ttgagcaact gcctcgtacc
      661 gtcctccgcg cggtcaaaat tctgttcaat cttcatgtag tccacaaagt tcagatttat
      721 tttctgagga aagttcatga cggcacgctt tacaaaatag gtactgtcca gcatgacgta
      781 taaatgtccc gtaaaaccga acgactcgga gttgaaaggg acaaatgtca agtcaacaca
      841 aggctttccg gcaacggtaa gcgtatccat cagataatat ttgtagaaag acagcccaag
      901 agaggaaagc gggctgacaa acttattggt gaacaaggtg atgttgttct cataaaggtc
      961 tacatcggtc atggtgacac tgatagcctg ctccataccc tgctgggaaa gcatttcgtc
     1021 cactcctgcc tgcctgcggg cggtgaccca ctgtttccgg ctatgcggag acttgcggta
     1081 atagtctgtg gcaagcaact cacggttgga gatggccaat accggcctgc cggtaacggc
     1141 agaggtatcg acataatccg tcagaaactt gaacttacgg taaagccact tctgttgctt
     1201 caagctgtcg aagttattga tggcaaaagt catcttttca tagcggtcac gtttccagaa
     1261 gtcgcgttcg tcgggcgagt agtcatcccg atgctctatc atcttgcgta caaactccac
     1321 tgcgggatta tcctttttct tataccgttc acgtttcggc ttcaccacca cctcatccaa
     1381 tgcataagtg gctggcgaaa gggctatatt gaacttagaa gactttgcag gatgaatcag
     1441 ccggacatat tcattatatc ccacggccga aatgaccagc gtggccttcg ggcgataggt
     1501 cttgaaggaa aaacggccgt tattgtccgt catccctccc tccgtagttc ctttcagata
     1561 aactgacgta taaggcaatg gctccttcgt caacgaatcg gtgacaacgc cttgcaccat
     1621 atattgtgct ctcaatggaa gagtaaccag ctggataagc agaaataccc taaaaaacaa
     1681 cttcatacct tgttttacct aatttggatg gcaaaggtac ggaagaaaac tttttcttaa
     1741 agttcggttt tacggaataa atgttctaaa aaactccttt tgtataaaac acttcccgtt
     1801 aaaagccgtt gtatagcgaa acgacgctcc agaaagcatc ggaacaacca atatataacc
     1861 taaacaactt gattatggaa tggattttca accagctcag ggaacgcccc gaacttgcca
     1921 ttttcctcac tatattcctg ggattctggc tggggaaact gcgtatcggt aagtttacgc
     1981 tgggcacagt gaccagtgta ctgcttgtag gcgtactggt agggcaactg aatatagccg
     2041 taccgggtcc gataaagtcg gtattttttc tgcttttcct ttttgccgtg ggctataaag
     2101 tgggtcccca gttcttccgc ggactgaaaa aggacggatt gccccaagtg ggctttgccg
     2161 tactgatgtg tatatccgta ctgttagtga cctggctgct ggccctgatg atgggctaca
     2221 atgccggtga agctgccgga ctgctggccg gttcgcaaac catctccgcc gtcatcggag
     2281 tggcagaaga caccatggcc aatatgggac tggacgaggc ccaacgacaa agttacgtca
     2341 acatcattcc cgtatcctac gccgtcacct acattttcgg tactgcaggc tcggcatggg
     2401 tcctatcatc catcggtccc aagatgctgg gcgggctgga aaaggtgaaa gccgcctgca
     2461 aggaactgga ggcgaagatg ggcagctctc tggctgacga accgggattc atgccagcag
     2521 cacgccccgt cactttccgt gcctaccggg tcgaaaacga atggttcaag aatggaaagc
     2581 gggtgattga cctggaagtc tacttccggc agcacgacaa acgtctattt gtggaacgcc
     2641 tccgcaaatc cggaattgtg gtggaagtca gcatgaacct acggatagag ccgggagacg
     2701 aagtagtgct aagcggacgc cgtgaatata tcataggcga agaaagctgg atagggccgg
     2761 aagtacaaga tgcccagctc ctggattttc ctgccgaaaa gttaccgatt acaatcacac
     2821 gcaagacggt tgccggcaag acggttgcag ctatccgaag ggaaaagttc atgcacggtg
     2881 tcagtatccg gagcatcaag cgcgccggaa tatccattcc cgtgctggca caaacggtag
     2941 tagatgccgg cgacgtcatc gaagtggtag gtaccaggca ggaagtggaa gcagcagcca
     3001 aacgtctggg gtatatagac cgtcctacca accagacgga tatgatattc gtaggcctgg
     3061 gtatccttgt cggaggtttg ttcggagcac tttccgtcca tatcggcggc atccccatca
     3121 gcttgagcac aagcggcggc gcattgattg ccggcctgct cttcggctgg ctccgcagta
     3181 agcaccccac cttcgggcgc atccccgaac cttcacaatg ggtattgaac aatgtcggtc
     3241 tgaacatgtt cattgcggta gtgggcattt cggcaggtcc cagtttcgtg cagggcttcc
     3301 acgacgtagg tatcagtctg tttctggtgg gagcagccgc caccaccctg ccgctgatta
     3361 tcggcttgct gctggcaagg tatgttttca agttccatcc ggcactggct ttgggcgtct
     3421 gcgcgggggc acgtaccacc acggccgctt taggcgcggt gcaggatgcc gttgagagtg
     3481 agacacctgc tctgggatac accgtgacct atgccgtggg caatacctta ttaataatat
     3541 ggggtgtagt catcgttttg ctaatataag acgattctgt accaatgctt actaatccag
     3601 agcattcaaa gaattattgc cggaaatgca agcgactata tacccattca ctaatagcta
     3661 ttcatccgac agctgtcgga cgataattca acagttgtcg gacgatgatt caacaactgt
     3721 cggacgaaaa ggaaacatat atcggacgat taatttcaag caaggaaaga aatagtacac
     3781 cgcatgaaca gagattattc gccgaatgac tgaaaacaat aaataacgaa cctaaacttg
     3841 agcttatgga tacaaaactt ttagaaaaga aaatggaatc tatcagtcct ttcgaactga
     3901 agaaccgcct gatagacatg gcagacgaaa gtctgaagaa aaccgcccgt accatgctga
     3961 acgcaggtcg cggcaacccc aactggattg caaccgctcc acgcgaagcc ttcttcctgt
     4021 tgggaagctt cggcctggaa gagtgccgcc gcatcatgga tttgcccgag ggaattgcag
     4081 gcatccccga aaaaaaaggc attgcctccc acttcgaagc cttcctgaaa aagaacaata
     4141 acgtaccggg cgccaaattg ctggaacaaa cctacaacta cctgctgatg cagcatgccg
     4201 ccgaccccga cagccttgta cacgaatggg ccgaaagcat tgtaggcgat cagtatcccg
     4261 tgcccgaccg catccttcat tttacggaaa tccttgtgca agattacctt tcgcaagaga
     4321 tgtgcgacaa ccgtcctccc cggggtgcct atgacttgtt tgccaccgaa ggtggaacag
     4381 ccgccatgtg ctatatcttc gactccctgc aggaaaactt cctgctgaac aaaggggacg
     4441 gcatcgtcct catggttccc gctttcaccc cctatattga aattccacaa ctcagccgct
     4501 accagtttcg agtgaccaaa atacatgcca accgcatgaa taacgaaggg atgcacctct
     4561 ggcagtacag cgacgaagac atagaccgct tgaaaagccc taaaatcaag gccctctttg
     4621 tcaccaatcc cagtaatccg cccagctaca cactcagtcc ggatacaatg gcgcgcatcg
     4681 tgagcatcgt caggaatgac aaccctaatc tgatgattat tacagacgac gtatacggta
     4741 cattcagtcc acacttccgt tcgttcatgg cagaaattcc ctacaatacg ctttgcgtct
     4801 attcattctc caaatacttc ggtgccaccg gatggcgcaa tgcggtcatt gccctgcacg
     4861 aattcaacct gttcgacaag ctgatagcca aactgccgaa agaaaaacgg gagattctgc
     4921 accaccgcta ctccaccctc actctggaac ctgaaaaact gaagtttatc gaccgtatgg
     4981 ttgccgacag tcgccaggtg gcactgaacc ataccgccgg actgtcattg ccacaacaga
     5041 tgcagatggg ccttttcgcc gcctttgccc tgctggacaa ggaaaacaaa tacaagcaaa
     5101 agatgcagga gattatccgc cgccgattgc atgccctttg ggagaatacc ggtttcacgc
     5161 tgacggaaga cccgttgcgc gtaggttatt atacagaaat cgacatgctg gtttgggcaa
     5221 agaagttcta tggggacgac tttgtagaat atctgaaacg tacctacagc ccgctgaacg
     5281 tagtcttccg ccttgccaaa gaaacctctc tggtgctgct gaacggcggt ggttttgacg
     5341 gccccgaatg gagcgtacgc gcctcactcg ccaatctgga cgagaaagac tatgcaacca
     5401 tcggccaagg catcaaaaag atactggagg agtatgcaaa agaattcttt aaaaatggaa
     5461 aggcgaaagg taaaaattga aaattgaaag gtgaaaggta aaactttcaa ttttcaatta
     5521 aatagtatac ggaagcgggt caatccatcg ttgtaggtac gtagggagaa cgtgcaacca
     5581 tgacggctca aaacttcccg gataaacacc aggccaattc cctgcccgtt cggcttggtg
     5641 gaaaagaagg ggctgaagag tttagcttcg gtctctttac ttatccccgg accattgtca
     5701 acgacttcga cagaagcggg ggcagtggtc cttactatta tctcaccttg ctgtccgttt
     5761 tctccggcat ccccctctat actttcggca gcattcttga tgatattcac aagcacctgc
     5821 tcaaaaagag aagcatccat acgcaccatt cccacctccg agtcgcattc cagacgtagc
     5881 tctatattgc ggtcattgca cattccttcc atgaaacgct tgcacatgga caccaactca
     5941 ttcagttgga cgggtgccag ggtaggttcg ggtatcttta ccacatctgc aaaacgggta
     6001 atgaaacggc tcatcgagaa acaacgctcc gtacagacgc gcatcacgtc acagatgtcc
     6061 tccatatcat cttctgtaga aagtgcctgc tccactgtat cgagtgtgga agtgatgccc
     6121 gcagtggtat tgttcacttc atgagctatc atgcggatta ccttttcata ggcacgcttc
     6181 tcggcacgca tcacttcttc cgtcatacgc tctatcaaga aaaaaggatg tttgaaccct
     6241 ctgtcaataa aagaagaatg ggtgcattta taaatattcg catcattgag acggaccact
     6301 gccgtctcgt ctttgggaat ggacgaaagt tcggcagcca acggggagtc catctggtcc
     6361 aaccgctttg ccatcgcctc ctccatacgg acaccgagca tctttaccgc catcggattc
     6421 agttgcgaca cttcatcgtc cattgtcagg ataataaccc ccattggaga tgcctgaatc
     6481 agcaaatcca agaagtgatt ctgctcgcgc atgcgcaacc gttcattctt gagctgctcc
     6541 atcattcggt taaagatatt cacaatgcgg tctgcttcgt actgccctac ccggctgaga
     6601 cgactactga aatcctgctc gcgcaacaac tccataccgc tgcctatggt gttcatcggc
     6661 ttcactatct tattatagaa tactatcaga tagataagga taaacccgat gagcccctcc
     6721 aacacgtaca gatacaaaga aggctttcca ctcagcagat ataccagcat tccacccaga
     6781 ccgagcagaa aaaggacaag tatgaagaaa aagaatttta tgcgcacggg acttgaatat
     6841 tatatttttc caaacgtctg taaagcgcag cgcggctgat gcctaatgac actgccactt
     6901 gactgagatt ccctttatgc tgttccaacg cctgcaagat agtctgccgc tctatttcat
     6961 ccaaggtcat acctgcaaaa gaagtacctt cggcagcttt ggccggttcg tcgtgacgca
     7021 gatattgggc atcaaaatcc gtggcatcca gcaccggctt gccgctgacc agaatggtac
     7081 gctccactag attcttcaac tcacgaatgt tgcccggata aggcaggcgg gaaaggaaat
     7141 tcagagcgtc ggccgagaaa tccgtacgcg gcaagccgtt cacctctgcc tgacggtcgg
     7201 caaagtgacg tgccagcaaa ggaatatctt cacggcgctc ccgcaaggag ggcagtttta
     7261 cggtaatcag gttgatacgg taaaaaaggt cttcacggaa agtacgttcg gacaccatct
     7321 tgcggaggtc tgcattagtg gcggacacaa cgcgcacatc gactttgcgg ggacggctat
     7381 cgcccagcac ttcgaatgtc tggtcttgaa gcacgcgcag cagtttcacc tggcaggaag
     7441 ggtcgaggtc accaatctcg tcgaggaaga tagtaccttt atttgccatt tcaaaacgcc
     7501 ctatacggtc ggcgctggca tcggtaaacg cccctttctt atggccgaac atctcgctct
     7561 cgaacaagct ctgcgatatg ccaccaaggt tcaccttgac aaagggctgc ttcacgcgtt
     7621 ggctgttgat atggatggct tcggcaatca gctccttgcc cgttccgctt tcgcccgtaa
     7681 tcagcaccga agcattggta cgggctatgc gagccactgt gttcagcact tccatcagcc
     7741 ctttggactt acctataata tggctgcgat tcaatgcggt agtctgctct tccggcacct
     7801 ctttcggggc ggccgtaagc tcaagggccg tctcgatgcg ctgcaaaaga gcagcattgt
     7861 tccaaggctt agttatgaaa tcgaatgcgc cggcctgcat accctgcacg gcaagctgga
     7921 tacttcccca tgccgtcatc aaaataacgg gcacatcggg acggaacacc tttacctgct
     7981 tcaataaggt aagtccctct tctccggtag tggaaagagt gaagttcata tccatcaaaa
     8041 tcaaggcggg agcttcggcc ctaactatat ccatagcttc gcgagggccc ggagccgttt
     8101 tcacctcata tccggcacgc ttcagcataa agctgaggga agagcgcaca gcactatcgt
     8161 cgtctattat cagtatcata aaaattgtag tttgtttccc gcaaaaataa gtaaaaaagc
     8221 agagttatga atgataagtt ataagttatt tacctataat atcgcatata cggtactttt
     8281 accggcaaat aattcataac ttatcacttg caacccgtcg acttatcctc ttaccacctc
     8341 ttcaaaatca gcttccaatt ccgtatcgcg ttcaaaatcc caaagggtca agctgcggag
     8401 ctgatagaag taataccaat agtagtacag ctctgaaata tgcttttgac gggcttcgtc
     8461 tttagagttc tgtgcatcgt tcaggtccag ggtgctgatt ttacctatca taaaggtctc
     8521 tacactggtc ttgtaacgct tctcagcaat gacatccgcc tcttcggcta tgtccagctg
     8581 ttgcgcctgg ttgttgaagt tagccaccag caaaaagatg tcctgattaa agtccatctg
     8641 ttcctgacgg attctggaca agaccacttc acggttgctc tttgccaccc ttaccttgcc
     8701 gcggcgcttg ccccagtcaa ggataggaat cttgacgcct acctgcacaa tctgattatc
     8761 aagcaagtcc cggtaggctg aagagaattc atggttctgc cccgtatagc ccacactggc
     8821 aaagaggtcg atgctgcgca agtttccgcg tgccgttgcc acttcataat cagcttcgag
     8881 ctggcggcgg cgaatgttct gtgcaaagga gttgcgttcc agtgccttgt tcagcacacg
     8941 gtcatactcc atctttatat cgggaacagt ggcgggcaac accggattca ggctttcctg
     9001 ctcggacacc ccgaggaaag aacggagctg gaacattttt gcattcaggt tgctctctgc
     9061 ctcagtcacg tcggccttgc cctgcaatga attcagttta agctgcaaca aatcattctc
     9121 ggatatctgt cccattttac gtttggctat ggccacttca taaaggcggt cggcattcgt
     9181 cttgttctgc atggcggtag cgagcgattc tttggccagc agcaactcaa agaaataagt
     9241 gatggttttc atcgtcacct cttccgtagc tgaaatgaac tcggcctttg cctcggcata
     9301 gcgtacgggc tctatacggc ggttccactt caaggtattc actccgaaga ccggttgcgt
     9361 caactccaga ctcacgggga ctgacatgaa ctgcttcgct cctccggaac ccagttgttt
     9421 gagataatcc agcgaagaag tcagtgacag cttacccccc gtaaaccaaa tgttctggtc
     9481 taccgaaagc tggccggaca gccccagtgt attgttgcgg acaaagctat aggagccgtc
     9541 ggaattctgg taggtactgt aggacttgtt atagttgggt agtgtaccgg tgaaattcac
     9601 ttccggcaac aagtccgcac ggaatgtacg gtattcccaa tacgcggttt tcaattcatt
     9661 caatgccaca gcagcatcca cagactgcgt acgggccagt acaatggcct ccgacagcgt
     9721 aatattgcgt tcatgtccca aagtatcatt ctgcgccatg gttgccaacg gcatcaaaaa
     9781 acaaactgca agtaaaatat tctttttcat gttcaatctt taaaattgtc gcaaacagaa
     9841 aagcaaagag tgtgccaagt ggccgggaag atttcataga ggggtaagtg ttcattttcg
     9901 gacagtgggg atgtccgtta gcggacgata tcaggaaaac aaccggtctc tatctaaagt
     9961 ctgaaaaaat ccttctaaag ttcaattatc catgaattaa ttgatgaaaa atttctttat
    10021 taaggaagaa ttctctttct ttgtgctgct ttataccttt attaaaaagg atacaatact
    10081 aacattaatt tatatagtta tgaagatttc acacattgag catctgggca ttgccgttaa
    10141 gagcattgaa gaagcccttc cgtactacga aaacgtttta ggtttgaaat gctacaacat
    10201 cgaaaccgtg gaagatcaga aagttagaac cgctttcctg aaagtgggcg atgtaaagat
    10261 cgaattgttg gaacctactt ctcccgaaag cacaattgcc aagttcatcg aaaagaacaa
    10321 cggtaacggt ggcatgcatc atctcgcatt cgccgttgaa gacggagtgg ccggtgcgct
    10381 tgccgaagtc gaagaaaaag gtatccgcct tatagacaaa gctccccgca aaggtgcaga
    10441 aggtctgaac attgcattcc tgcatccgaa gtcaaccctc ggcgttctga ctgaactttg
    10501 cgaaaaaccg gaataagcac gaccataaat cgtccaacca taaattgtat aaacattaaa
    10561 gaatataaat tcatgagtaa tcaacttgaa aagattaaag agcttataga ccgccgcgct
    10621 gcagcacgtc tcggtggtgg tgaaaaagcg attgcaaagc aacacgagaa gggtaaatat
    10681 acagctcgtg agcgtatagc catgcttctt gacgaaggca gtttcgaaga aatggacatg
    10741 ttcgtagaac atagatgcac caacttcggc atggaaaaga aacactaccc cggtgacggt
    10801 gtagtaaccg gttgcggtac aatcgaaggc cgtctggttt atatcttcgc acaggacttc
    10861 acagtttctg ccggttcact gtccgaaacc atgtctctga aaatctgtaa gattatggac
    10921 caagccatga aaatgggtgc tccgtgtatc ggtatcaacg actcgggcgg tgcacgtatt
    10981 caggaaggta tcaatgcctt ggctggctac gctgaaatct tccaacgtaa catccttgct
    11041 tcaggtgtca tcccgcagat ttccggtatt ttcggtcctt gtgccggtgg tgccgtttac
    11101 tctcctgcat tgactgactt tacgctgatg atggaaggta catcctacat gttccttacc
    11161 ggtccgaagg tagtaaagac tgtaaccgga gaagacgtaa gccaggaaaa cctgggtggc
    11221 gcgagcgttc actccaccaa atcaggtgtt actcatttca ctgcacagac tgaagaagaa
    11281 ggcttggctc ttatccgcaa actgttgagc tacattccac agaacaatct ggaagaagct
    11341 ccttatgtag actgcacaga ccctatcgac cgtctggaag attccctgaa cgacatcatt
    11401 cctgataacc cgaacaagcc gtacgatatg tacgaggtaa ttggcgctat catagataat
    11461 ggtgagttcc tcgaaatcca aaaagattat tcaaagaata tcattatcgg tttcgcacgt
    11521 ttcaacggac agtccgtagg tatcgttgcc aaccagccga agtatctggc aggtgtgctc
    11581 gacagcaacg catcccgcaa gggcgcacgc ttcgtccgtt tctgcgacgc cttcaatatt
    11641 cctatcgtat cattggtaga cgtaccggga ttccttccgg gaaccggcca ggagtacaac
    11701 ggcgtcatcc tgcacggtgc caaactgctg tatgcatacg gtgaagctac tgtacccaag
    11761 gttaccatca cactgcgtaa atcctacggt ggttcgcaca tcgtgatgag ctgtaagcag
    11821 ctgcgtggcg acatgaatta tgcttggcct actgctgaaa tcgctgtaat gggtggtgca
    11881 ggtgccgtag aagtattata tgcccgcgaa gccaaagagc aggaaaatcc ggctcaattc
    11941 ctggctgaaa aagaggctga atacaccaag ttgtttgcca atccttataa tgcagctaaa
    12001 tatggctaca ttgatgatgt tatcgaaccg cgtaacacac gtttccgcat cattcgtgcc
    12061 ctgcaacagt tgcaaaccaa gaaattgact aacccggcta agaagcatgg taatattccc
    12121 ttgtaatcaa gcttttcaca ctaaaacaag aacgattatg aataaaacaa aaatcggaat
    12181 attcctttca ttgatgctgg tgttaggctt ttgctcttct tgcaaagaac agaaatcgaa
    12241 caacaaactg ctgctgaatg aagtgctggt caacaacgaa agcaactatc aggatgacta
    12301 cggtgtgcac agcgcatgga ttgaaatatt caacagttca tacggcagcg ccgaccttgc
    12361 aggttgctat ctgaaattca gcagccagcc gggtgatact gccagttatt tcattcccaa
    12421 aggtgacgtt ctgacactca taaaaccacg tcagcatgca cttttctggg ctgatggaga
    12481 accaagacgc ggtacatttc atacgaactt caaactggat gccacaaatg ccaactggat
    12541 tgggttgtat gattccggca agaaattgct tgatcaagtc atagtgcctg ccggtacttt
    12601 aaaagccaac caatcctatg cccgtgtcag tgatgcagcc gaccaatggg aagtaaaggg
    12661 tggaagcgaa gataaatatg tcactccgag taccaacaac aagactatcg acagcaatgc
    12721 caaaatggaa aaattcgaag agcatgacag cgtaggtatc ggtatggcta tttctgccat
    12781 gagcgttgta ttctgcgggc tgatattact ctacatctcc ttcaagatta taggtaaaat
    12841 atcagttaac ctcagcaaac gcaatgccat gaaagctaaa ggtattactg ataaacaaga
    12901 agcaaaagag aaacaactgg ggcaggctcc gggagaagtt tttgctgcca tttcaatggc
    12961 catgcacgaa ttccaaagcg atgtacacga tgtggaagac acgatactta ccattacccg
    13021 tgtaaaacgc agttactcac cgtggagttc aaagatttat acgttgcgtg agactcctca
    13081 caaaaagtaa gtcacccata ataaaataaa acgatgaaag aatataaata taaaattaac
    13141 ggtaacatat ataaagttgc cattggagat attgaagaca acatcgctca tgtagaagtg
    13201 aacggtactc cctacaaagt tgaaatggaa aaagcaccga aggtagttgt taaaccggta
    13261 gcacgtccgg cagccacatc cgctcctgct gctcctgcta ctccggtagt aaaaccggcc
    13321 gctgcttcta ccggcaagtc aggtgtaaaa tctccgcttc ccggtgtaat cctcgatatc
    13381 aaagtaaatg tcggcgatac agtaaagaag ggacaagtta tcatcatttt ggaagccatg
    13441 aagatggaaa acaatatcaa tgctgataaa gacggtaaga ttacagccat caatgtaaac
    13501 aaaggggact ctgttctcga aggtactgac ctcgtaatta ttgaataata tgggagaatt
    13561 tatcacattt ttaggaaaca accttgccga cttctggact tatacaggtt ttgccaatgc
    13621 aacggtagga catgtggtaa tgcttctggt aggtttgttt ttcatatact tggctgtagc
    13681 caaggaattt gagccgatgc tattaattcc tatcggtttc ggtatgctga ttggtaatat
    13741 acctttcaat atggaggctg gattgaaagt cggtatctat gaagaaggtt ccgtacttaa
    13801 tattctgtac cagggagtaa cctccggttg gtacccgcca ctcatattcc tgggtatcgg
    13861 tgccatgacg gatttctctg ctttgatatc gaaccccaaa ttaatgttgg ttggtgcagc
    13921 agcccaattc ggtatattcg gtgcttatat gattgccctt gccataggat ttgacccgat
    13981 gcaggctggt gcaatcggta tcattggtgg tgccgatggt ccgactgcca tcttcctctc
    14041 ttctaaactg gctcctaact taatgggtgc cattgcagta tcagcctatt catatatggc
    14101 attagtaccg gtgatacagc cgcctattat gcgttggctg accagtaaaa atgaacgtct
    14161 tatccgtatg aaacctcccc gtgtggtttc acatacggaa aaagtaatgt tcccgattat
    14221 cggtttgtta ctgaccacat tccttgtacc atccggtctg cctttgctgg gtatgctgtt
    14281 cttcggtaat ttactgaaag aaagtggagt tacacgtcgt ctggcaaaca cagccagtgg
    14341 tccgctgatt gataccatta ctattctgct tggtttgaca gtaggtgctt ctacgcaagc
    14401 atccgagttc ttaacccttg attcaatcaa gatattcggt ctgggcgcct tatcatttgt
    14461 cattgccaca gcatccggtg tcatcttcgt gaagattttc aacctcttcc tgaagaaagg
    14521 caacaagatt aatccgttga tcggtaatgc cggtgtatct gccgtacccg actctgcacg
    14581 tatctcccaa gtagtaggtc tggaatacga tcctaccaac tatctgctga tgcatgccat
    14641 gggcccgaac gttgccggtg taatcggttc cgctgtagca gcaggtatcc tgctgggatt
    14701 cttaatgtaa tacatttatt cattccgtta tccggcttga attctgaact attttagagc
    14761 cccttcattt ttggaggggc tttttcgtta atctatctaa aacagattac gattatttcg
    14821 taaatacatt ctttttagta acttgcagtc agtttaacct catataaatg atatactgta
    14881 tgcgaaagct ttttatctcc ttatgtttca gtgcatgctg ttcgcttctg gcggcacaga
    14941 ccacaaatcc cattcaagag gcgatggcca actacgatta tgaaacagcc ttgatgctga
    15001 tcgatcaaga aaccccgacc gtccccctac tctaccaaaa agggaaagcg ctgaaagggc
    15061 tgggcaataa ccttgaagct ctgagcgtat ttcaggaagt cgtagctcag gattctctca
    15121 atccccgggc atacattgaa gctgccgaat gctgcaaatc acttgccaaa tatagcgagg
    15181 cactggatta ctaccaaaat gcgctccaca taaatccgga caataaatac gcacgcatcc
    15241 agtatatcag tctgctgatg aacatgaaga gataccgtga gtctctaaag gaaagcaacc
    15301 tgctggcaga aagggacagt tccgcctatg tactacacct tagagccgaa agtatggggc
    15361 aagtctatga caacacagaa atcatgcatg tgatagatgc ctacctggac atacagaaaa
    15421 gatatcccaa tgattacctg tctgctgcca aactcggcaa catctatgta gcaggccacc
    15481 agtatgaaga cgccataaac ataacggaga aataccgttc catagactcc accaacgtcc
    15541 ttgtgaaccg catcaatgcc caagcctatt gcctgaacaa agattacccc aaagcaatag
    15601 aaagatatga acaactgtta caggaaaaag acagttcttt ccaaacctgc ttctacgccg
    15661 gaatcagcta ttatgccctc gaagacttct acccagcaca cgacctgctg gaaagggctc
    15721 ttaaagatga caataccaac atcaacgttc tctattatct gggacgcgcc tgctccaaga
    15781 catcatggaa agaggatgga gtgacttatc tggaaactgc cgtaagcctc gccatgccca
    15841 gcgacagtgt catgtcccgc ctatatgtgg ggcttgcgga ctgctacaag atggcatttc
    15901 aatacaccga ccaggcgaat acccttctga cgcaatacga aaaatacgac cggcagaaac
    15961 acaaactgct ctacgacgca gcctttatct attattacta tctgaaagat gcgtccaaag
    16021 cagagagata cctaacggcc tacctgaaaa cccgtccgaa aaacagcaag gacaaagtgc
    16081 aggaagtaga tgcggacgga gttcccatca tcggagaaga caaccgatac aatgccgccg
    16141 aaaactggct gaaggacatc agagaaaagc gcaagaaaga ggacttcttc aagggaaagg
    16201 tcgataccgc cagcgtaacc cccatcaaat agccccaatg acaacgtttg cataatataa
    16261 taaggtacag tagagggtgt gtcaaaacag gcacatcctc tttttttcta atcgctagct
    16321 tgtctctaat ctaagtttac ctatgccgca attttcggaa gcggcgactt caaagtcgcc
    16381 caattcatcc cataaatcgc ttttaagtgt gt
//
