LOCUS       c00037_gnlPro..        15025 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CNPMHLPD_37.
ACCESSION   c00037_gnlPro..
VERSION     c00037_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 20:02:03
            Original ID  :: gnl|Prokka|CNPMHLPD_37
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 189156
            Orig. end    :: 204181
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15025
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[199156:204014]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14858
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..15025
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15025
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(55..936)
                     /locus_tag="ctg37_160"
                     /transl_table=11
                     /translation="MRIGKKDIMAFIVLFLATIVCVRYFYKNMSDEQFVATVDPYSLVI
                     PTPTAIFAINRPPVFEKMILPMENIRKAFSDHTPAIFLSLIQQNPDLSSFLIAYYPQGD
                     ILYAPMDSHTAERIFKQLDASFTFPAQQREEASVPVRYYPDVDKHFLGCYYHEGIFVVS
                     YNRKLLVETAKKQQMYPAQIIPELADLISKKGKSGAMNLFIQSASLDLQVQMNDSTEWK
                     MKNQWLAMDLFYNEGSLCCFNEQPYEETLENFYPNLCDTITTRINRLFPQIKTTAQVSH
                     DEAVVYFTVCGN"
     CDS             complement(933..1598)
                     /locus_tag="ctg37_161"
                     /transl_table=11
                     /translation="MRKIETEKTMRKEERYKGVLNWFKENVPVAETELHYDNPYQLLIA
                     VILSAQCTDKRVNMITPALFEAFPTPEVMAASTPEVVFEYIRSVSYPNNKAKHLVGMAK
                     MLIEDFKGVVPSDIDELQKLPGVGRKTANVIASVVYDKPAMAVDTHVFRVSNRIGLTNN
                     SKTPLETEKELVKNIPEELIPIAHHWLILHGRYVCLARKPKCEECGLKPWCKYFLKQT"
     CDS             complement(1740..4253)
                     /locus_tag="ctg37_162"
                     /transl_table=11
                     /translation="MKTLKYLLVTMLLLGVCSLTYSQKLSLGIFPEPQEVTISSQTYAP
                     PHGYALRGINNPDADAVKLLKETLPFAKSGKSLPLEIKKLKDKTPEMQRSGAYTLTITK
                     KGITIGIVDDNSLFYAAQTLKQLAKYDEGKKILPLCSIKDYPDVLFRGTVEGFYGQPWS
                     HADRIEQIRFYGRIKLNTYIYGPKDDPYHSSPNWRKPYPAEEAEHIKELAKEAAHNKVN
                     FVWAIHPGQDIQWNLTDSMNILSKFEKMYDLGVRSFAVFFDDISGEGARPEKQAGLLNY
                     IHKEFISKKNDVQPLIMCPTEYNRSWAKTDYLDILGTQLDPAIQIMWTGDRVVADITKE
                     GVEWVNNRIRRPAYIWWNFPVSDYCQDHLLMGPAYGLDTQAAGTMTGFVSNPMEYAEAS
                     KVAIFGVGMYTWNIENYDPTQAWKDACDFIMPEASMAFRIFCEHNCDPGPNGHQYRREE
                     SANYVAPIQTFLAGYKKNTFPEQSANLLGTLFAQITASPSMIYSQSPNKRLIEQINPWL
                     IQFEFLGKAGTSALHMAHAWYEKDRSYTWQRYLETSALLDSMKLINRTLNQKAQPKGVK
                     VGSKVLHPFIVDLYRQTGRNLLSTDGIAPDEVKVSIPSIFTNIDQLKSQPCAEGDNTVG
                     YVPLFEVVKVQPNQYLGIGWEIQKEAESFCFNLPKSNQPGRVFEWSADGKSWSLIPHVS
                     TENAKDTIRTIDPKARYIRMRNNSDQQMELYVLGFTATTQQDPQINEALMMYDMNLDTY
                     KNLNPGEIIHIKCDDINAVSFFLSGSNENLVSITGLSQDGEKNIVYQGNVGYIKLNKTM
                     FEDFSSLEITTIGKEPIHIHQIVRE"
     CDS             complement(4356..5939)
                     /locus_tag="ctg37_163"
                     /transl_table=11
                     /translation="MIKITYKLILLLSLLAMTVTSFAASEAEYGKISKAWTLHADGSQE
                     YRSSMELTLFTHTAMNSTYGESFIVYNPDFQTLKIHSSYTRQKDGTIVKTPDNAFVEVL
                     PRFAADAPAYNQLKEMVVVHTGLELGATIYLDYSIITKPGYYPALDINERLQETSPVKE
                     CKVSISVPEGTPLACGLYGSPVKAVEESHDSIKEVHWTLRNIPASSREAFQPKNREASP
                     HLVASTYPSGKAALATLDKRLKESQGYESKTFAQFLTDKSGNEQEKVNIIRDHILNNLS
                     TCPIPMAMTGYTVRDIDTVLRSAYGTPLEIAQLLNVMLNAAGIPSEVLAVYPGHLDTDA
                     CGLAAIQTLAVKATVDGKDQYLSASPLTNRGGLDKVVSLSGASIEIETTPIQIKESRSV
                     AISTDQAKGGFAICVLPAISAGIDSWGMSTLNSKRSNLFELPSLIREEVTYTVTPAEGM
                     KLQTSTKEQVISKPFGKVTRTITPRGNTIEVVRTIELDKQQFTPAEYSDVRSLIHEWTN
                     PDNRVLLFSL"
     CDS             complement(5953..7914)
                     /locus_tag="ctg37_164"
                     /transl_table=11
                     /translation="MKRILTITAVSLLALSPMYGQDSCRYPQDPTLEKSQAYAGYDCVT
                     LLDSTAVTVQPTGSGAFAVCKAFKVQTSKGAVANRIIKYDYDPLTAHAEFRYATIYRAN
                     GDVINLDVTQACDYAAPARAIYWGARQIMLEVGRLQPGDIVEYEIAKKGFTYALLTAGD
                     DDERFIPPMRGQFYDIVPFWATEPTVRKVYRVSMPMEKELQFQFYQGECTSSMRYEDGR
                     KVYTFASDDILPFAKEPNMVDLFDAAPKLMMSSTPRWEDKSVWFNKVNEDYGSFTAIPE
                     AQKKVDELIKGKKTEMEKIAVLTHWVADNIRYSGISMGKGEGFTLHNLKMNYTDRCGVC
                     KDIAGTLIAFLRMAGFEAYPAMTMAGSRVESIPADHFNHCVAVVKLASGTYMPLDPTWV
                     PFCRELWSSAEQQQNYLPGVPEGSDLCLTPVSAPENHYVRIHADNRLDEKGTLRGQFTI
                     TAEGQSDSNIRRIFTTGWQSDWQNTMEKQLLTVSPNAKLLRVDYGKDPKNYQAAPIKIT
                     FSYEIPDYAIIAGDQMLIKPLVMNNLYNQVKSFLRIDTKPENRTYGFKDACSRLVEQDE
                     TIRLPKGYTLLNAPKNDALQSNAADFEGSLSQEGDQNIVLRQKLALKKRVYDPADWKGF
                     RSAVNAYKSYGDYLIIKK"
     CDS             complement(7917..8915)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 52.6; E-value:
                     9.5e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_165"
                     /sec_met_domain="AMP-binding (E-value: 2.6e-16, bitscore:
                     52.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIQEDLQAFLAEWHDPSPFLEVQTSGSTGTPKRMRVRKDRMLNS
                     ARLTCDYLGLKKGDKALLCMPLRYIAGKMMVVRSLYAGLDLEVCEPSGHPLADWGDTPL
                     RFAAMIPLQVYNTLRVPEERKRLEQTDILIIGGGAIDAALEQEIRQMPNTVYSTYGMTE
                     TLSHIALRRLNGPEASPYYHPFPSVTLSLSPDNTLVIDAPLVCDERLVTNDVARLLPDG
                     SFAIIGRKDNIINSGGIKIQIEEVEERLRPYLDRPYAITAAPDPRLGEAVVLLLASNLR
                     GEMLTEVLASLPKYLRPRHIIKVSEIPQTGSGKIDRAACRELARNIITKTL"
     CDS             complement(8919..9977)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_166"
                     /sec_met_domain="MR_MLE_C (E-value: 2.5e-28, bitscore:
                     92.5, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKERFYKTEVVPRCLTFKRPAGTSRGVYTTRKLWEVRIRKEDEP
                     SAFGIGECAPLPDLSCDYGVDYEITLSKACLDLEQKGHVDTESLRHYPSILFGLEMAMR
                     HYEQGSWRHYDTPFSRGQAGIPINGLIWMGDYKYMLEQVEEKMKEGFRCVKLKIGAIDF
                     DRELSLLKHIRAHFSAKEIELRVDANGAFLPSEAMDKLKRLAEMDLHSIEQPIRAGQLE
                     EMARLAAESPLPIALDEELIGCNAPDEKRRLLETIHPQYIILKPSLHGGIAGCTEWVHL
                     AETILGSTPEQPKWWVTSALESQIGLNAIAQWCATLGNPLPQGLGTGEIFKDDKHKLIQ
                     RKGDTIWFTNDL"
     CDS             complement(10001..10825)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_167"
                     /sec_met_domain="ECH_1 (E-value: 4.5e-81, bitscore: 265.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKREWTTIKEYEEILFDFYNGIARITINRERYRNAFTPTTTTE
                     MSDAFYICRERPDINVVVLTGAGDTAFCAGGDMNVKGRGGYVGKDGVPRLNVLDVQKQI
                     RSLPKPVIAAVNGFAIGGGHVLHVVCDLTIASENAIFGQTGPRVGSFDAGFGSSYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLDKLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATMLYYMTDEAQEGGKAFLEKRRPRFEDYPKFP"
     CDS             complement(10829..12517)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_168"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-06, bitscore:
                     21.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLIEHGVSNIVLCPGSRNSPIVHTLANHSFFN
                     CHSVTDERSAGFFAVGLALHGGKPAAVCCTSGTALLNIHPAVAEAFYQKVPLVVISADR
                     PAAWIGQMDGQTLPQPGVFGSLVKKSVQLPEIHTDQDEWYCNRLINEALLELNHHGKGP
                     VHINVPISEPLFQFTTPELPKVRVITRYQGLNVYDRKYDDLIERLNKYSKRMMIAGQMS
                     LIYLFEKKICKLLYKHFTWLSEHIGNRIVPGLPIKNFDAILYATPEEEKEKLVPELVIT
                     YGGHIVSKRLKEFLRKHPPKEHWHVSLDGEVADLFGSLTTVIEMDPFEFLEKIAYMLEN
                     RQIKYPKAWEYKSRNLPEPEFAYSEMAAIGGLIRSLPAESALHLGNSSTVRYAQLYTVP
                     ETVEVCCNRGTSGIEGSLSTAIGYASASQKLNFIVIGDLSFFYDMNALWNGNLHNNLRI
                     LLLNNGGGEIFQALPGFKMNERTHRYVTASHQTSAEGWATERGFSYSAVHNAEELAAAM
                     SAFTQTEQPSEHPLFMEVFTDKAEDVRLLKEYYHQLKNSSQAQNI"
     CDS             complement(12532..13629)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_169"
                     /sec_met_domain="Chorismate_bind (E-value: 2.1e-53,
                     bitscore: 174.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPRDSYEIIDTLIKQGRSFAIWRIPGEDRLHFRMQSAGSPCLLY
                     DIKDLNERSGFVIAPFQVTAERPIVLIQPDCFEIPSESDWDFSREKNEFPSNEIEIPSE
                     SEEKERYAYHFSLFTNPLLKGSQDKLVLSRSKTIWKDPSFSPGKAFFAAEERYIRSYVY
                     LCHTPETGTWMGGTPEILLSGEKGDWQTVALAGTQSLRDGKLPKSWDHKNWREQQLVAS
                     YIRRQLSTLGITPEEKGPYSARAGEVSHLKSDFFFSLPNPEKLGDVLQLLHPTPAVCGL
                     PKEEAYHFIIENEGYDRSYYSGFIGWLDPKGKTDLYVNLRCMNILPQTFTLYAGGGLLA
                     ASQLEDEWQETEDKLDTMRRIVGNL"
     CDS             complement(13626..14858)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_170"
                     /sec_met_domain="HBT (E-value: 2.4e-16, bitscore: 53.4,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDKKEITPRTHAALLKAQQMGVHVVLASGR
                     PTNGVQPLAEALELNHYGGFILSYNGGQIINAQTGELMFEKRIDPAMIPYLNRKAKENG
                     FAIFTYHKDYILTDSPENKHVQEEAELNKMRIIGVENFPEAVDFAPCKCILTSDDENNL
                     VGLENHWKKRLDGVLEAFRSEDYFLEVAPHFINKGNTLAVLMEMLNITTEEVVAIGDGV
                     ADVSMLQLAGTGVAMGNARDSVKACADFTTLPNNMEGVAVAIEKAILATIKPTEVPLDQ
                     LNARAKHALMGNLGIQYTYASEDRVEATMPVDERTRQPFGILHGGATLALAETVAGLGS
                     MILAKPDEMVVGMQVSGSHMSSAHEGDTVRAVGTIIHKGRSSHVWNVDIFTSTDKLVSS
                     VRVINSILKKK"
ORIGIN
        1 tttattcgta aaagatatgt ttgtgtcagc attcaagaaa gaagggactg aagcttaatt
       61 cccgcaaacc gtaaaataga ccacggcctc gtcatgactg acttgtgccg tggtttttat
      121 ttgtgggaat agccgattga tccgagtagt tatcgtatcg cataagttgg ggtaaaagtt
      181 ctccaaggtt tcttcatagg gctgctcatt gaagcagcaa aggcttcctt cattatagaa
      241 taaatccatt gccaaccatt gatttttcat tttccactcc gtcgagtcat tcatttgaac
      301 ctgtaaatct aaagaggcgc tttggatgaa gagattcatc gcgccactct tgcctttttt
      361 actaattaga tcagctaatt ccggaatgat ctgtgcgggg tacatctgtt gctttttcgc
      421 tgtctctacc aataattttc gattgtagga caccacgaat ataccctcgt ggtagtaaca
      481 acctagaaaa tgcttatcaa catccggata gtatctaaca ggaacggaag cttcctctcg
      541 ttgctgggca ggaaaagtga aagaagcgtc cagttgcttg aaaatacgct ctgccgtatg
      601 actatccata ggggcgtaca agatatcccc ttgtggataa taagcgatca agaaagacga
      661 taaatccgga ttttgctgta ttaaagagag gaaaatagcg ggcgtatgat ccgagaacgc
      721 cttgcgtata ttctccatgg gtaatatcat cttctcgaat acaggaggac gattgatagc
      781 aaaaattgct gtgggggtcg ggatgaccaa gctataggga tctaccgtgg cgacaaattg
      841 ctcgtcgctc atattcttgt aaaagtacct cacgcaaacg atcgtagcca aaaacaagac
      901 aatgaatgcc attatgtctt tcttgccgat cctcatgttt gctttaggaa gtatttacac
      961 caaggcttta atccgcattc ctcacatttc ggtttccggg cgaggcaaac atatcttcca
     1021 tgtaatatca accagtgatg ggcgatgggg atcagttctt ccggaatgtt cttcactagc
     1081 tccttttccg tttccaaggg tgtcttgcta ttattggtca agccgatccg gttggagaca
     1141 cggaatacgt gcgtatctac cgccatggct ggcttgtcat atacaacgga tgcgattacg
     1201 ttcgcagttt ttcttcctac acccggaagt ttctgtagct cgtcaatatc ggagggaacc
     1261 acgcctttga agtcctctat cagcatcttc gccataccta ccagatgttt agccttattg
     1321 ttcgggtaag atacgcttcg tatgtattca aagacgactt ctggtgtgct agctgccatt
     1381 acctcgggag tagggaaagc ctcgaacagg gcaggagtga tcatattcac tcgcttatcc
     1441 gtgcattgtg cggataggat taccgctatc aataattgat atggattgtc ataatgtagt
     1501 tcagtctcgg ctaccggtac gttttcctta aaccagttta atacgccttt atatctttct
     1561 tcttttcgca ttgttttttc ggtttctatt tttcgcatcc taaaggtata acttttaaaa
     1621 ggaatataca agcggagatg tgccaaaaat aagatactcc cgaattgtac gaataaataa
     1681 aaaagtaccg atctccttct tccatctaag agagaaagaa atcgggattt ttttatttat
     1741 tattccctaa cgatctggtg gatatgtata ggttcttttc ctattgtggt gatttctaaa
     1801 gaagagaaat cctcgaacat ggttttattt aatttgatgt agcctacgtt cccttgatag
     1861 acgatgtttt tctcaccatc ttgagagagg ccggtgatag ataccaaatt ctcgttactt
     1921 ccggagagga agaaagatac ggcgttgata tcatcgcatt ttatgtgaat tatttctccc
     1981 ggattcaagt tcttatacgt atctaggttc atatcgtaca tcataagagc ctcattgatt
     2041 tgcgggtctt gttgggttgt cgccgtgaat cctagtacgt atagctccat ttgctgatcc
     2101 gagttatttc gcatacggat ataacgggct ttcggatcga tggtgcggat tgtatcctta
     2161 gcgttttccg tggagacatg agggattagg ctccagctct ttccgtcggc ggaccactcg
     2221 aatacccgtc cgggttggtt gcttttcgga agattgaaac agaaggattc cgcttctttc
     2281 tggatttccc agccgatacc cagatattga ttaggctgta ccttgactac ctcgaatagg
     2341 gggacgtaac cgaccgtatt atcaccctcg gcacaaggct ggctcttcaa ttggtcgata
     2401 ttcgtgaata tggaagggat gctaaccttc acctcgtccg gggcgatacc gtccgtagat
     2461 agcaggttac gacctgtctg acgatataag tctacgatga aagggtgtaa gactttcgat
     2521 ccgactttca cgcctttagg ctgtgccttc tggttcagcg tgcggtttat cagtttcatg
     2581 ctatctagca aagcggatgt ttccagatag cgttgccacg tataagaccg gtctttctca
     2641 taccaagcgt gcgccatatg cagagcgctt gttccggctt ttcctaagaa ctcgaattgg
     2701 ataagccatg gattgatttg ctcgatcaag cgtttattgg gactttggct gtagatcatg
     2761 ctcggggaag ccgtgatttg agcgaataag gttcccagaa gattcgcgct ttgctccggg
     2821 aacgtgtttt tcttatatcc ggcgaggaat gtctggatag gagccacata gttagcggac
     2881 tcttcccggc ggtattgatg tccgttcgga cccggatcgc agttatgctc gcagaaaatg
     2941 cggaaagcca tggaggcctc cggcataata aagtcgcaag cgtctttcca tgcctgtgta
     3001 ggatcgtaat tctcgatatt ccaagtgtac attccaacgc cgaatatagc gaccttggaa
     3061 gcctcggcgt attccatagg attggatacg aatccggtca tggtgccggc ggcttgcgta
     3121 tctaggccgt aggcgggtcc catcaacaaa tgatcttggc aataatcgct tacggggaag
     3181 ttccaccaga tataggcggg acgacggata cggttgttta cccattcgac gccttctttc
     3241 gtgatatcgg ctacaacacg gtctccggtc cacatgattt ggatggcggg atcgagttgg
     3301 gtaccgagga tatccagata gtcggtctta gcccatgaac ggttgtattc ggtagggcac
     3361 atgatcaggg gttgcacgtc atttttcttg ctgataaatt ccttatggat gtaattcaat
     3421 aagccggctt gcttttccgg gcgggctccc tctccggata tatcatcgaa gaaaacggcg
     3481 aaagagcgta cgcccaaatc gtacattttc tcgaatttgg aaaggatatt catgctatct
     3541 gttaggttcc attgaatgtc ttgtcccggg tggatggccc aaacgaagtt tactttgtta
     3601 tgggcggcct ctttcgctag ttccttgata tgctcggctt cctcggcggg ataaggtttg
     3661 cgccagttgg gggagctgtg gtaaggatca tctttcggac catagatata ggtgttcagc
     3721 ttgatccttc cgtaaaagcg gatttgctcg atacggtcgg cgtggctcca aggctgtccg
     3781 tagaatcctt ccacggtacc ccggaataat acgtccggat agtccttgat cgagcagaga
     3841 ggcaggatct tcttaccctc gtcatattta gctaattgct tgagggtttg ggcggcgtaa
     3901 aacaaggaat tatcgtctac gatcccgatc gtgatacctt ttttagtgat cgtcagcgta
     3961 taggcacccg agcgttgcat ttccggagtt ttgtctttta gcttcttgat ctctaaaggg
     4021 agagatttgc cggatttagc gaaaggtagc gtttctttaa gtagtttgac cgcatctgcg
     4081 tccggattat ttataccccg tagggcatat ccatggggcg gtgcgtatgt ttggctggaa
     4141 atagtcactt cttggggctc ggggaagatt cctagggata gcttttggct atacgttagg
     4201 ctgcaaacgc ctagaaggag catggtgacg agtaaatact ttagtgtttt catatgcgat
     4261 atgatttaat gttaacgttc gtaaatgtag ggaataatta gacacgaagc acacggaggg
     4321 cacggatttg ttccgtgtgc tccgtgtttt agatcttata gggagaatag caatacccgg
     4381 ttatccggat ttgtccattc atggatcaag ctacgcacgt cgctatattc ggcgggagtg
     4441 aactgttgct tgtccaactc gatcgtacgt actacctcga tcgtatttcc tcttggtgtg
     4501 atcgtgcggg ttactttacc aaaaggcttg cttatcactt gctcttttgt ggaggtctgc
     4561 aacttcatgc cctcggcggg agtaaccgtg taggttacct cttccctaat tagggagggg
     4621 agttcgaata agttggaacg cttgctgttc aaggtgctca tgccccagct atcgattccg
     4681 gcggagatgg ctggcaatac gcagatggcg aaaccgcctt ttgcttgatc ggtggagatg
     4741 gccacggatc tactttcctt aatctgaata ggtgtggtct caatctcaat ggaagctccg
     4801 gagagggaga ctaccttatc tagtccgcca cgatttgtca gtggggaggc ggataggtat
     4861 tggtctttcc catcgacagt ggcttttacg gctagtgtct ggatggcagc cagcccgcaa
     4921 gcgtccgtat cgagatggcc gggatagacg gcgaggactt ccgacgggat tccggcggca
     4981 ttcaacatca cgttcaagag ctgcgcgatc tctagcggcg taccgtaggc actgcggaga
     5041 acggtatcga tgtcacggac ggtatagccg gtcattgcca tggggatagg acaggtactg
     5101 agattgttga gtatatggtc tcggatgatg ttcaccttct cttgttcgtt accgctttta
     5161 tcggtgagga attgggcgaa ggttttgctc tcgtatccct gcgattcctt taagcgctta
     5221 tccaaagtgg ctaaggccgc tttacctgaa ggataggtag aggctaccaa gtggggtgaa
     5281 gcctcacggt tctttggttg gaaagcctca cgggaggaag cgggaatgtt ccgtagtgtc
     5341 cagtgtacct cctttatact gtcatggctc tcctccacgg cttttacggg ggagccgtac
     5401 agaccgcaag ccaagggggt cccttccggt acggagatag agaccttaca ttctttcacg
     5461 ggagaagtct cttgtagccg ctcgttgata tccagagctg gatagtagcc cggttttgtg
     5521 ataatagagt aatccaagta aatcgtggcc ccaagttcta ggccagtgtg taccacgacc
     5581 atttccttga gttggttata ggccggagcg tcggcggcga aacggggtag gacctctaca
     5641 aaggcgttat cgggtgtctt tacgatcgta ccgtctttct gccttgtata ggatgagtgg
     5701 atcttcagtg tttggaaatc gggattgtag acgataaaac tctcgccata cgtgctattc
     5761 atcgcagtgt gcgtgaagag cgtcaattcc atggaggatc gatattcttg gctaccgtcg
     5821 gcatgcaagg tccaagcttt cgatatcttc ccgtactcag cctccgatgc ggcaaatgaa
     5881 gtaaccgtca tcgctaacaa gcttaggaga agaatcagtt tataggttat cttaatcatt
     5941 gtttttctgt ttttatttct tgataatcaa atagtcacca taactcttat aggcgttcac
     6001 tgcggaacgg aagcctttcc agtcggctgg gtcgtagaca cgcttcttca acgctagctt
     6061 ctggcgcaag acgatgttct ggtcgccttc ctgcgaaagg gaaccttcga aatcggccgc
     6121 attgctttgc agggcgtcat tcttcggggc gttcaagagg gtatagccct tggggaggcg
     6181 gatggtctca tcttgttcta ccaaacggga gcaagcgtcc ttgaatccat acgtacggtt
     6241 ttccggtttc gtatcgatac gcaagaaact cttcacttga ttgtagaggt tattcatgac
     6301 tagcggcttg ataagcattt ggtctccggc gatgatcgcg taatcgggga tctcataaga
     6361 gaacgtgatc ttgatagggg ccgcttgata gttcttcggg tccttaccgt aatctacacg
     6421 aagcagtttg gcgttggggg atacggtcag caattgcttc tccatcgtgt tctgccagtc
     6481 ggattgccat ccggtggtga agatgcggcg gatattgctg tcggactgtc cctcggcggt
     6541 gatcgtgaat tgtccgcgga gcgtgccttt ctcgtctagg cggttgtcag cgtggatgcg
     6601 gacgtagtgg ttctccgggg cggagacagg ggtcaggcag aggtcggagc cttcgggcac
     6661 acccgggagg tagttctgct gttgctcggc gctactccat aattcccggc agaaaggaac
     6721 ccaagtcggg tcgagaggca tatacgtgcc gctagccagt tttaccaccg ccacgcaatg
     6781 gttgaaatgg tcggcgggga tgctttctac acggcttccc gccatggtca tcgccgggta
     6841 agcctcgaaa ccggccatgc ggaggaaggc gatcaacgtg ccggcgatat ccttgcagac
     6901 accgcaacga tcggtataat tcatctttag gttgtgaagc gtgaaaccct cgcctttacc
     6961 catcgagatt ccggagtaac ggatgttatc ggccacccag tgggtcaata cggctatctt
     7021 ctccatttcc gttttcttgc ctttgatcag ctcgtctacc tttttctggg cttccgggat
     7081 tgcggtaaag cttccgtaat cctcgttaac cttattgaac catacggatt tatcttccca
     7141 gcggggcgtg ctggacatca tgagcttcgg ggcagcgtcg aataggtcta ccatattcgg
     7201 ttccttggcg aaaggaagga tatcgtcgga ggcgaaggta tatactttcc gtccatcctc
     7261 atatcgcatg gaagaggtac attcgccttg gtagaactgg aattgcaact ctttctccat
     7321 cggcatggat acccggtata ccttacgcac ggtaggctcg gtagcccaga aggggacgat
     7381 atcgtaaaac tgtcctcgca taggagggat gaaacgctcg tcgtcgtcac ccgccgtcag
     7441 caaggcgtag gtgaaacctt tcttggcgat ctcgtactcc acgatatctc ccggttgcaa
     7501 gcggcccact tccagcatga tctgccgggc gccccagtag atggcacgtg cgggggcggc
     7561 gtagtcgcaa gcttgggtta cgtcgagatt gatcacgtcg ccgttcgcac ggtagatcgt
     7621 ggcgtaacga aactcggcgt gcgccgtcag cgggtcgtaa tcgtatttga tgatacggtt
     7681 ggcgacggct cctttggaag tctgtacctt aaaagccttg catacggcga aagcccccga
     7741 gccggtaggt tgtaccgtaa cggcggtgct atccagcaag gtgacgcagt cgtatcctgc
     7801 ataggcttgc gatttctcca aggtaggatc ttgcgggtat cggcaagaat cctgcccgta
     7861 cataggcgat aaggccaata gggagaccgc ggtgattgtt agaattcttt tcatgtttat
     7921 agtgtttttg taatgatatt tctcgctagc tcccggcagg cggcacggtc gatcttgccg
     7981 cttccggttt gggggatctc gcttaccttt atgatgtgcc tcggacggag gtacttgggc
     8041 aggctggcga gaacctctgt tagcatctca cctcgtaggt ttgaggcaag cagtagcacg
     8101 accgcctctc ccaaccgagg gtcgggggcg gcggtgatgg cataggggcg gtcgaggtag
     8161 ggccgtagcc gctcttccac ctcctcgatc tggatcttga tacctccgct attgataata
     8221 ttatctttcc ttccgataat ggcgaaactc ccgtccggca gcaggcgggc gacatcgttc
     8281 gtcaccagcc gctcgtcgca aaccaatggg gcgtctatca ccaaggtatt gtccggtgac
     8341 aaggataacg tcaccgaggg gaagggatgg taatagggcg aggcttccgg cccgttcagc
     8401 cggcgcaggg cgatgtggga cagcgtctcc gtcattccgt aggtggaata aaccgtgttt
     8461 ggcatctgcc gtatctcctg ttccaaggcc gcgtcaatcg ccccgccgcc gataatcagg
     8521 atatccgttt gctccagccg cttacgttcc tcgggtactc gcaacgtatt gtaaacctgc
     8581 aaaggaatca tggcggcaaa gcgcaggggc gtatcccccc aatccgccaa cgggtgtccg
     8641 gagggttcgc acacctccag atccagtccg gcgtataggg agcggactac catcatcttt
     8701 ccggctatat agcgtaaggg catacataac aaggccttgt cgcccttctt aagccccaaa
     8761 taatcgcagg taagccgggc gctgttcagc atccggtcct tgcgtactcg catccgcttg
     8821 ggcgtaccgg tggagccaga ggtctggact tccagaaaag gggagggatc gtgccattca
     8881 gctaagaatg cctgtaaatc ttcttgtatc ggcataggtc aaaggtcgtt ggtgaaccag
     8941 atggtgtctc cttttcgttg gatcaactta tgtttatcgt ccttgaaaat ctcgccggtt
     9001 cccagacctt gcggtagcgg gttacctagc gtggcgcacc attgggcgat agcgttcagt
     9061 ccgatttgcg attccagagc ggaggtgacc caccatttag gttgttcagg ggtactccct
     9121 aagatagttt ccgctaagtg aacccattcc gtgcatccgg cgatacctcc gtggagggaa
     9181 ggctttaata taatgtattg gggatggatc gtttccaaca accgccgttt ctcgtccggg
     9241 gcgttacagc cgatcagttc ctcgtcgaga gcgatgggaa ggggtgactc tgccgcaagg
     9301 cgtgccatct cttccaactg cccggcacgg ataggctgct cgatggaatg caagtccatc
     9361 tcggcgagcc gcttcagttt gtccatcgcc tccgagggga ggaaagcgcc gttggcatct
     9421 acccgaagct ctatttcctt ggcagagaaa tgcgcacgga tgtgtttcaa taaagagagt
     9481 tcccggtcga aatcgatagc gccgatcttc agcttgacgc agcgaaagcc ctccttcatc
     9541 ttttcctcta cctgttccag catgtactta taatcgccca tccagatcag tccgttaatg
     9601 gggatacccg cctgccctcg cgagaagggc gtgtcgtaat gccgccaact accctgttca
     9661 taatgacgca tggccatttc caatccgaaa aggatggatg ggtaatggcg caaagattcg
     9721 gtgtcaacat gccccttctg ttccagatcg aggcaagcct tggataacgt gatctcgtaa
     9781 tccactccat aatcgcaact gagatccggc aggggggcac attcaccgat gccaaaagcc
     9841 gagggttcgt cttccttgcg gattcggacc tcccacaatt tccgggtcgt gtaaacaccc
     9901 cgtgaggttc ctgccggtcg cttgaaagtc aagcaccggg gaaccacctc tgtcttataa
     9961 aacctctcct tcaccattca ttctcaattt tcaattcctt ttacgggaac ttcggataat
    10021 cctcgaagcg tggacggcgt ttctccaaga atgccttgcc gccttcctgc gcctcgtccg
    10081 tcatatagta aagcatggta gcgtctccgg ccaactcctg tataccggcc tgtccgtcca
    10141 actcggcgtt taagcccgcc ttgatcatgc gcaaagccaa cgggctaagc aacatcatct
    10201 cctcggccca ttgaacgtac tcgtcctcta atttatccaa ggggactacc ttatttacca
    10261 aacccatatc caaagcctcc tgcgcattgt acttgcggca taggaaccag atctcacggg
    10321 cctttttctg tccgaccaca cgggcgaggt aagaagagcc gaacccggcg tcgaagctac
    10381 ccacacgagg accagtctgt ccgaagatag cgttctcgga agcgatcgta aggtcgcaaa
    10441 ccacgtgcaa tacgtgtccg ccgccgatag cgaaaccatt cacggccgcg atgacgggtt
    10501 tcgggagaga gcggatctgc ttttgtacgt ccaatacgtt caagcgaggt acgccgtctt
    10561 tacccacgta gccgccacgt cctttcacgt tcatatcgcc tcccgcgcaa aaggccgtat
    10621 ctccggctcc tgtcagaacg actacgttaa tgtccgggcg ttcccggcag atgtaaaagg
    10681 cgtcgctcat ctccgtggtc gtagtcgggg taaaagcgtt gcgataccgt tcccggttga
    10741 tcgtaatgcg ggcgatgccg ttgtagaaat caaataagat ctcctcatat tccttgatgg
    10801 ttgtccattc tcttttcgtt tccatatatt atatgttttg tgcttgggat gaatttttta
    10861 gttgatgata atattccttg agcaatcgta cgtcttccgc tttgtccgtg aaaacctcca
    10921 tgaatagggg atgttcgctc ggttgctccg tttgggtaaa ggcgctcatc gccgctgcca
    10981 actcctcggc attatggaca gcggagtagg agaatcccct ttccgtggcc catccctccg
    11041 ctgaggtctg gtgggaggcg gtaacgtaac ggtgcgtacg ctcgttcatc ttgaatcccg
    11101 gcaaggcttg gaagatctcg ccacctccgt tgttcaagag caggatgcga aggttattgt
    11161 gcaagttacc gttccacaac gcattcatat catagaagaa actaagatcg cctataacga
    11221 taaagtttag tttttgcgag gccgaggcgt atccgatggc cgtagacaag gagccttcga
    11281 tcccgctcgt acctcggtta caacaaacct caaccgtctc gggtacggtg tacaattgcg
    11341 cgtaacgtac ggtggagcta ttccctagat gcaaggccga ttcagccgga agcgagcgta
    11401 tcaaaccacc gatcgccgcc atttcggagt aagcgaactc cggctccggc aggtttcggg
    11461 atttgtattc ccaagccttc ggatatttaa tctgcctatt ctccagcata taagcgattt
    11521 tctccagaaa ctcgaaaggg tccatctcga tcaccgtggt caggctaccg aataaatccg
    11581 ctacctctcc atccaatgag acatgccaat gctccttagg cgggtgtttc cgcaaaaact
    11641 ctttcagccg cttggagaca atatggccac cgtaggtgat tacgagctcg ggaactagct
    11701 tctctttttc ctcctccggg gtagcataca ggatagcgtc gaaattcttg atcggtaatc
    11761 ccggtacgat acggttgccg atgtgctcgg agagccaagt gaaatgcttg tatagtaact
    11821 tgcatatttt cttctcgaag agatagatca agctcatttg tcccgctatc atcatccgct
    11881 tgctatattt gttcaagcgc tcgatcaggt catcatattt ccggtcgtac acgttcaagc
    11941 cttgataacg ggtgattacc cgtaccttcg gcaattcggg tgtcgtgaac tgaaataaag
    12001 gctcggagat cggaacgttg atatgcaccg gtcctttgcc gtgatggttc agttccaaca
    12061 acgcctcgtt gatcaatcga ttgcaatacc attcatcttg atccgtatgt atttccggta
    12121 gctgcaccga cttctttacc agcgagccga acaccccggg ttgcggcaag gtctgtccgt
    12181 ccatttgccc gatccatgcg gcggggcggt cggcggatat cacgacaagc ggaactttct
    12241 gatagaaagc ctccgctacc gccggatgta tattcagcaa ggccgtgccc gaggtacagc
    12301 aaacagccgc cggcttacct ccgtgcaacg ctagccctac ggcaaagaat cccgcgcttc
    12361 gttcatccgt cacggaatgg caattgaaga acgaatggtt tgccaatgtg tgcacaatcg
    12421 gagagttccg gcttcccgga catagcacga tattacttac gccgtgctct atcagcaagg
    12481 ctaccaattg aaggatgttc tttttatcgc tatacattat atgatataaa attataaatt
    12541 acccactatt ctccgcattg tatctaattt atcctctgtc tcctgccact catcctctag
    12601 ctgcgaggcc gccaacagac cgcctccggc atacagcgta aaggtttggg ggaggatatt
    12661 catgcaacgg aggtttacgt acagatctgt tttgcctttg ggatccagcc aaccgatgaa
    12721 accggagtaa tagctacgat cgtacccctc attttcgatg atgaaatgat aagcctcctc
    12781 cttgggaaga ccgcagacgg ctggagtagg gtgtaatagt tgaaggacat cacccagctt
    12841 ctcgggattc ggcaaggaga agaagaaatc acttttcaaa tgagaaacct ctccggcccg
    12901 ggctgaataa ggccccttct cctcgggagt aatacccaag gtggacagct ggcggcgtat
    12961 ataggaggcg actaattgct gttctctcca attcttatgg tcccagcttt tcggtaattt
    13021 cccgtctcgt aaggattggg ttccggccaa agctaccgtt tgccagtcac ctttctcgcc
    13081 ggataacaag atttccggtg tcccacccat ccaagttccg gtttccgggg tatggcaaag
    13141 gtagacatag gagcggatat atcgttcttc cgcggcgaag aatgccttgc cgggtgagaa
    13201 agagggatct ttccagatcg ttttgctacg ggataggact agtttatctt ggcttccttt
    13261 tagcaaaggg ttggtaaaca gggagaaatg gtaagcgtat cgttccttct cctcggattc
    13321 ggacgggatt tcgatttcat tcgaagggaa ttcgtttttc tctcgagaga aatcccaatc
    13381 ggattcggag gggatttcaa agcaatccgg ttggattaaa acgataggtc gttccgctgt
    13441 cacctgaaac ggagcgatta caaaaccgct ccgttcattt aagtctttta tgtcgtataa
    13501 taggcaagga gagccggcac tttgcatcct gaaatggagc ctatcctcac cgggaatacg
    13561 ccaaatagcg aaactccggc cttgcttgat caacgtgtct attatttcgt aagaatctct
    13621 tggaatcatt tcttctttag tatactattg attacccgta cagaggaaac cagtttgtcg
    13681 gtagaggtga atatgtctac gttccacaca tgggatgaac ggcctttgtg gataatcgtc
    13741 ccgacggcac gtaccgtgtc tccctcgtgg gcggacgaca tatggctgcc gctaacttgc
    13801 atgccgacta ccatctcgtc cggtttcgcc agaatcatgg aacctagtcc ggccacggtc
    13861 tctgccagag ccagtgtagc gcctccgtgc aagataccga aaggctggcg ggtccgttcg
    13921 tctacaggca tggtcgcttc cacacgatcc tccgacgcat aggtatattg aatgcctaga
    13981 ttacccatta aagcatgttt ggcccgtgcg tttagttgat ctaacggaac ctctgtgggt
    14041 ttgatcgtgg caaggatcgc tttctcgatc gctaccgcca caccttccat attattgggt
    14101 aaggtcgtga aatcggcaca agcctttacg gaatcgcgtg cgttacccat cgccacgccg
    14161 gtaccggcta attgaagcat ggatacgtcg gccacgccat caccgatagc gacaacctct
    14221 tcggtcgtga tattcagcat ctccatcaat accgccaacg tatttccctt attgatgaaa
    14281 tgaggagcta cctccaagaa atagtcctcg gagcggaaag cttccaatac cccgtccaga
    14341 cgtttcttcc aatgattttc gagacccact agattgttct cgtcatcgct ggtaagaata
    14401 cacttacagg gtgcgaaatc caccgcttcc gggaaattct ccacaccgat gatgcgcatc
    14461 ttattgagtt cggcctcctc ttggacatgt ttgttttccg ggctatcggt taggatatag
    14521 tccttgtgat atgtgaagat cgcgaaaccg ttttccttcg ccttccggtt taaataagga
    14581 atcatggccg gatcgattcg tttctcgaac atcaattctc cggtctgggc attgatgatc
    14641 tgacctccgt tataagataa tatgaaacca ccgtaatgat tcaattcaag agcctccgcc
    14701 aagggttgaa ccccgttggt gggtcggccg gatgccaata caacatgaac tcccatctgc
    14761 tgagccttta acaaggcggc atgggtccgg ggagttatct ctttcttgtc gttaagcaac
    14821 gtcccatcta cgtctaagac taataatttg tacttcatgg cgtcttattt ttatggttta
    14881 ttttacaaag ttactacaaa aaagtgaaat gcggaaagat atagtgatag aattgagtta
    14941 caagggtttt agttgaagtg gcgataattc gtgaagccat tacaatccct gccgaagcca
    15001 aatcttgacg ccgcaacgtt acttg
//
