LOCUS       gnlProkkaEELMNMAH_99   13692 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EELMNMAH_99.
ACCESSION   gnlProkkaEELMNMAH_99
VERSION     gnlProkkaEELMNMAH_99
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 16:15:23
            Original ID  :: gnl|Prokka|EELMNMAH_99
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 5265
            Orig. end    :: 18957
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13692
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10273]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10273
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13692
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13692
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(16..1491)
                     /locus_tag="ctg99_5"
                     /transl_table=11
                     /translation="MKQTSSQPRLDGKIPGRIKYTFALGALGKDMIYGMIATFSMIYFT
                     DIIKVNPVFIGVMFFVAKLWDAFNDLFMGMIVDNTRSRWGKFIPWLVIGTLVNSIVFVV
                     LFTDFHLDGVGLCVFATAAYILWGMTYTVMDIPYWSIIPNLTSNPEEREKVSVLPRIFA
                     SIGQSLVIAGFGVQIIEALSGGTTNQAGYHRFAIIIAIVFILTIGITVINLPKKRDDSV
                     PEKKVKFKDIFSIIGKNDQLRWAVTLIFLYNIGIQCIMGVATYYFKYVCGNAGMMSSFM
                     ISASIAEVVGLIVFPKVAKFLSRKTSFLLACLLPAFGLVMLLLVGIFAPHNVVLTSISG
                     VIVKLGTGLELGCATVFLADVVDYGEFKLGTRNEGVVFSLQTLIVKFTAALTALGIGAA
                     LGSTQYIPGQEQSFATVASISTLMCIVPAVCMLIAYVVYRKKYKLNDGMMKKVINTISA
                     RREGKIDMTQQLDESGNTEPSMFLPTVAEKAGK"
     CDS             1720..2733
                     /gene_functions="regulatory (smcogs) SMCOG1078:LacI family
                     transcription regulator (Score: 230.4; E-value: 5.5e-70)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg99_6"
                     /transl_table=11
                     /translation="MATIRDVAKKANVSVATVSRVLNNDTTLSTSLETKQKIFAAAKEL
                     NYVKKKRVISAPSCRIGILQWFSSKQEIEDNYYFLMRQGIEDYCSKNNISIVRTFKTDN
                     DYQNVLCDVDGIICLGKFSKQEIKLLHSLNNKIVFLDMTVENIEITSVSLDFRQAVSDA
                     IKYLYDLGHRTVGFIGGIEQLEDGTIFPDKRLNTFTDICDELNIKYDGFIIQDKFSTSS
                     GYKMMSEMISKGNLPTAIFAASDHIAIGAMRALQENGYKIPEDISVMGFDNTELSGYTN
                     PPLTTVNAPVYAMGIYGIRFILNMMKSKSTDYFSPMRVYLPCPIKVRNSCAKPKSL"
     CDS             complement(3066..6062)
                     /locus_tag="ctg99_7"
                     /transl_table=11
                     /translation="MKKFKKYLSVVLACTIAVSAAVVSSSAVDNDDIDTYGSGLEKTSD
                     ATNNLQNGSFENPSIGEKNYDQVDHDNVPNWSTSATDERIELLRENNIYLKDLIENTDL
                     QGTTLTPPDELQAAELNAEQDSTLYQYINTSSGSCYEWSLQHRGRCGTDTMALVIGPKQ
                     SYNPTKASKNSRDQFMQMIDWLKNNEDESTSEKIKNQQSGDKPIECVVYSKKFASNGTF
                     ENASDRNFSLTQTDVFSEEWHIWIIKSNNREWHKYGKGSETAESSDYYRYIVPEGSNQS
                     IFAFVSYQGTDAKNSRPDRHNTFGNLLDGITFDLYHPAETIVNTGGTGTVTYTQNGSKT
                     NVEITPQSNNNPLEIMVDDNTELEITAKPSFAKDDNGNFRLDGENRKIPNMFIGSYVTI
                     NGERRYLKSEEFTRETDADGNACYKYNFENISGRVTVELFFSEIYTVTYLSNGGEKYSV
                     KDKGSGTGFSVLDDTVNVARFNEKKSGNYTATACNWKDSDSGTHFYGWEYVSPGSDDNA
                     TVFNSDVNVTYNYDGSVEPQTLDFVITGTLAGTNRKKTITTNARNGAVFKARWYFKHDV
                     IAQTKQNDGTYVNSSNGGHVTVNKTDDMYNFSDIGDYGKTFYSFKDKTVTATATAMDGY
                     RFVGWYEKTADGEAYINNRTSHTYTVDDSSTILYARFEHDDYRIRFHINDPLKTLANAN
                     DDVYVSYIPAYDNAAEMETVRSLNTDKTVSPFYDIPEVIGTGSQRMVFKGWYRNKANDD
                     DSNPIQFNGTKFVTDADVYAHWIDIGTVSKAKDDDKIGVSSYCGFDLFGTQIRNADDDD
                     NYPVKPSSFDKSGLRFVTSFSEKLLSDIDKLDGTETRPEYGYVLAKKSTAEKAAQLAGV
                     SSDSYELEYNGENVNGKDTTGKTSYGYVTNVNCTSNKSYRGGIVPLDHFNSDNYRIFSL
                     VITYKKGDSASQSQNVIARPYIRYTDANGLFRTYYSNYTGSSKLYGGCSTSFNSVKRII
                     AENYNIIQK"
     CDS             6196..7554
                     /locus_tag="ctg99_8"
                     /transl_table=11
                     /translation="MKFTVDFSILLSYNVIILLNLWYRKVKGLKNSPYATVERFVDRLL
                     LGKETDCEAIRKYEIYLTYDNIINMSMYCKALILVLFMCMVFRSILHGVNEVNTVPFAI
                     ATMITLVIMFFLKKYIDPQNHTVKTSRILTYAYSINICAIAMYYDLILQPEEYDVFLLI
                     VIVVLSGMFNKHPCEHLVFLICLLGILIVIEARLAPSKIFLTDLFNAIIAAAAGIFLAV
                     AEMRTKIELIMIKENEHKIKMSDIKTQIVLNQIKPHFLYNVLATIQVLCKFDPDKAVTA
                     MEDFSGYLRANVDYGLSKSVVSFDEEFKNVQYFLRLEKLRCGDKLKIVYELKEKNFEIP
                     VLTLQPIVENAVKHGVGNKKGGGTVTISTSSDDNNIIIRVQDDGDGISAKSIDELSLSY
                     DGKSHVGLTNVKERIEIITGGSLDFYSEKGKGTVVTIKIPKDFKEATYEYTRS"
     CDS             7535..8353
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 66.3; E-value: 4.9e-20)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg99_9"
                     /transl_table=11
                     /translation="MNILAVDDEPIMLWSLKNSLKKIFTKNDDSVNGFDEIDDAMNYVD
                     SLGNEKLDYAFLDIRLRGIDGINFATLIKEKQPGVKIVFCTAYSDKALDAFEVNAIGYL
                     LKPITEDKIRNLLKQIEYMFKDSDERAHIEVKTFGNFDVFVDGKAVIWHRQKAKELLAF
                     LIDKRGTSVTNSEIALALWETDANVKSVATIISSLRSTLKEYGIEKILVRSRNSTAIDT
                     TKLKCDVYDLYNGSKEAKNLYNGEYMANYSWAEFTNAHLIAYTGYNFKKK"
     CDS             8453..8647
                     /locus_tag="ctg99_10"
                     /transl_table=11
                     /translation="MQRVVTKFLTIFMCFIILLLTFSGCGKNRDNGSSAISSSATQQTV
                     SESSSSGSDDVEVDFSDLQ"
     CDS             8684..9049
                     /locus_tag="ctg99_11"
                     /transl_table=11
                     /translation="MKKIAGVLLACIICLSAVFCIGVSATEIKLGDVNNDSVINVKDAT
                     LIQKHICNVENLNGEALVAADVDKNGLINITDATYIMTFVVSLIDEFPNEPKTEPSTEK
                     TSLSTDSEGYYNVVVKP"
     CDS             9092..9238
                     /locus_tag="ctg99_12"
                     /transl_table=11
                     /translation="MKDTYEKIEIEIKEINCDDVIATSSPTTSQKENAYFSFDDLFGDT
                     YFD"
     CDS             9295..10011
                     /locus_tag="ctg99_13"
                     /transl_table=11
                     /translation="MAVYKIADINIKINCHGNYLKNLLKNYRCDYTDYDFEVVATDNDI
                     QAEKIIADGFGDEMYESSAVLRKISEKLLYEYDGILFHGAVIEYKSKAYLFCAPSGTGK
                     TTHIMLWKKYLKDEVTILNGDKPFVRIIDNVPIIYGSPWRGKENLGKNDFCKLDAIVFV
                     NRNKQNFARHLSPDESLFRLLSCTAYPKNSVGKLKTLEFLENLSAKIKFVDLFCNMEYN
                     ACRTALNALTEEIYEN"
     CDS             10001..10273
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg99_14"
                     /sec_met_domain="PF05402 (E-value: 3.6e-16, bitscore: 49.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.7e-13,
                     bitscore: 40.8, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKNGFILRNFSDKIVAVPEDDFADNSNLFIKMSSSAEFVWNFL
                     QSDKTYEEVLDALLEKYDIDRQTAENDLNNFLSTVRNAGLLDEQS"
     CDS             10260..10670
                     /locus_tag="ctg99_15"
                     /transl_table=11
                     /translation="MSSPEQIIEEYGFYSAPVHGMSMYPLLKNHRDAVCILPPDKLKKY
                     DVVLFRRQSGQLVLHRILKIDGNRFYICGDNEFRKEIVYKNQIIGKMTEFCRNNKNGKV
                     TDFKYKIYSYCWNSSFLIKRILLRIYAKFFKG"
     CDS             10672..11829
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg99_16"
                     /sec_met_domain="NTP_transf_5 (E-value: 5.6e-32, bitscore:
                     101.4, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKSLITVGTAVCRLIGQFTNKNIHINKNSLPPVPTMVKFAKMHS
                     IETMLYAGLKKSGFTDDELGDLPEQAELLSFCQIKNDAFAARLSANFSNAGIEHMIIKG
                     IEFSKYYPPKLLRTSTDIDFYMSGKDAERVARGLEERGFTRIEDDCTVIALAKKPCSHI
                     EIHIGFNAVNKKQSKFYADLLKNAQYKNNSRRYFSEENNLLFALLHLYKHFSKSGAGVR
                     MLLDIYLIQKKCIFDIESIQKKTADLGIDKFFNSVCEISDYLFEGKSLDNRMFPALEFF
                     FSSGTFGTNDAYLTINAAKYSGKTSKIKNYLKSEAGFSNENIKNKYPLAKKFPVLLPYF
                     HVHRVVSGFIHKGKSVGRVITDSKVVTSDNAAKQLIEVMELMGIN"
     CDS             complement(12088..12867)
                     /locus_tag="ctg99_17"
                     /transl_table=11
                     /translation="MDIFITILVTFFAGMGAGLGTGFAGMSAAAVISPMLITFLNMDPY
                     MAVGIALSSDVLASAVSAYTYHKNKNLDVRNGLIMMASVLAFTIVGSYVASIVPSATMG
                     GFSVFMTFLLGIKFIIRPVMTTKEAMLGVSAKKRAIQSVICGMLIGFICGFIGAGGGMM
                     MLLILTTVLNYELKTAVGTSVFIMTFTALTGAASHFMIGGTPDWFVFILCIAFTLIWAR
                     IAAVFANKAKPKTLNRATGIVLVVLGVVIMGFKLLAK"
     CDS             complement(12910..13692)
                     /locus_tag="ctg99_18"
                     /transl_table=11
                     /translation="MKQGWKVNDSRMIALIAICAVAGVLTVRYIKVGLYLEILIAFVFA
                     QILFMFSGTTFAPMISAIVLPVMMQTESFIYPIAAFLLTIAVVLFRRFLLKVKIRDKED
                     FQSVNLHAKSDVIDTAVRTICVAVVGFFAIWSGFKFAIAPPLLVAFTEFSRPKNKARNK
                     PVKTVLLITVCAFVGAVSRYVLNMTLGLPLTVAALTATAIMLVIVYCTKMYIPPAGALT
                     ILSMIIPSESVLLYPLQILVGTAVIMLISRLLFMKRQN"
ORIGIN
        1 ttagtatcaa tcattttatt tacctgcctt ttctgcaact gtaggaagaa acatagaagg
       61 ctctgtgtta ccgctttcat caagctgttg tgtcatatca atcttgcctt ctcttcttgc
      121 actgattgtg tttataacct tcttcatcat accgtcattg agtttatatt tctttctgta
      181 aacaacataa gcaataagca tacaaaccgc aggaacaatg cacataagtg tactgattga
      241 tgctactgtt gcaaatgact gttcctgtcc cggaatatac tgtgtgcttc caagtgccgc
      301 gccaatacca agtgctgtaa gagctgctgt gaattttacg ataagcgtct ggagtgagaa
      361 tacaacgcct tcatttcttg ttccaagctt aaattcaccg taatcaacaa catctgcaag
      421 gaatactgtt gcacaaccaa gttcaagacc tgtaccaagt tttacaataa cacctgagat
      481 tgatgtgagc acaacattgt gcggagcaaa aatacctacg agcaaaagca ttacaagacc
      541 aaatgcaggt aaaagacacg caagaaggaa cgaagttttt cttgaaagaa attttgcaac
      601 cttagggaat acgataagac ctacaacctc tgcgattgat gcgctgatca taaatgatga
      661 catcattcct gcgttgccgc aaacatattt gaaataatat gtagcaacac ccataatgca
      721 ctgaatgccg atgttataaa ggaagataag agttaccgcc caacgaagtt gatcattctt
      781 gccgatgatt gagaaaatat ctttaaactt aactttcttt tccggaacag aatcatctct
      841 ctttttcgga agattgatta ctgtaatacc gattgtaaga ataaatacaa ttgcaattat
      901 gattgcaaat ctgtgataac ctgcctgatt tgttgtgccg ccgctgagag cctcaataat
      961 ctgaacacca aagcctgcaa taacaagtga ctgaccgata cttgcaaaga ttctcggaag
     1021 taccgaaact ttttctctct cctcaggatt tgaagtgagg ttaggaataa ttgaccaata
     1081 aggaatatcc ataactgtgt aagtcatacc ccagagtatg taagctgctg ttgcaaatac
     1141 gcaaagtcca acgccatcga ggtggaagtc tgtgaataaa acaacaaata caattgaatt
     1201 aaccagcgta cctattacaa gccatggaat aaatttaccc catctgctgc gtgtgttatc
     1261 aacaatcata cccataaaca aatcattaaa ggcatcccat aactttgcaa caaagaacat
     1321 tacgccgata aataccgggt taaccttgat gatgtctgtg aaataaatca ttgaaaatgt
     1381 ggcaatcata ccataaatca tatctttgcc gagggcacct aaagcaaagg tgtatttgat
     1441 tctacccggg attttgccat caagtcttgg ttgtgatgat gtctgtttca taatttttcc
     1501 tccttttgat tttaaatgaa acgccgtgac aacctgcaca aaagatttcg ttattattta
     1561 ataataatgt ttcttttgtt tttatgttaa ctaaattata tgttttgttt cgtaaactgt
     1621 caatagtttt tggtaaacat ttttgctttc tctgtttttc actaaacacg acttgatttt
     1681 ttagtaatat ttcactataa tggtagtgag gtgattcaat tggctacaat cagagatgtt
     1741 gccaaaaagg caaatgtatc agtagctact gtttcaagag tgcttaataa cgacactacc
     1801 ctcagcacct cgcttgaaac gaagcaaaaa atatttgcag cagctaaaga acttaattat
     1861 gtaaagaaaa aaagggttat atcagcacct tcatgtcgca ttggaattct acaatggttc
     1921 tcttccaaac aggaaattga agataattat tactttttga tgagacaggg tatcgaggac
     1981 tactgttcaa aaaataatat aagtattgta cgaacattta aaacagacaa tgactatcag
     2041 aatgtacttt gtgatgttga tggcataatc tgcctcggaa agtttagtaa acaagaaata
     2101 aaattactgc attctttgaa taataaaatt gtttttcttg atatgaccgt tgagaatatt
     2161 gaaatcacat ccgtatcgct cgactttcgt caggcagtgt ccgatgcaat taaatatcta
     2221 tatgatttag gccatagaac agttggcttt atcggaggca ttgaacagct tgaggacgga
     2281 acgatatttc ctgataaacg actcaacact ttcacagaca tttgcgatga actaaacatt
     2341 aaatatgatg ggtttattat acaggacaaa ttttcaacat catccggtta taaaatgatg
     2401 tcagaaatga tcagcaaagg aaatctcccc acagctattt ttgcggcaag tgatcatatt
     2461 gcaatcggtg caatgagagc tctgcaagaa aacggttaca aaattcctga ggatatttct
     2521 gttatgggat ttgataacac ggagctttcg ggatatacaa accctccgct caccacagta
     2581 aacgcacctg tatatgcaat gggcatttac ggcattagat ttattttgaa tatgatgaaa
     2641 tctaaaagca ccgattattt ttctcctatg cgtgtctatc tgccttgtcc aataaaagtt
     2701 cgcaactcat gtgcaaaacc taaaagttta taattattat cgttatcata cgattgtatg
     2761 ctataataaa ttataattat aactccacaa atgatagatt aagccggaag tttataattc
     2821 ttttaatgaa ttataataac taaaaattca ttttgcaccc ctactcaaaa gctatgatta
     2881 cattgataaa tgtacaacat ctatcgtttt ggtacaattt cagtgactta ttgacaaact
     2941 tacctgctga ttttcagaaa tatgtaaaaa ccgcaaaagg cacataaccg tcatcacttt
     3001 cggttatgtg ccttattatt tttgttaggc tgttttttac agcctcattt tatttgcaga
     3061 aagctttact tctgaattat gttataattt tcagcaatga ttcttttcac gctgttaaag
     3121 cttgtactgc atccgccgta aagctttgaa ctgcctgtat agttgctgta gtatgttctg
     3181 aaaagaccgt ttgcatctgt atagcggata tacggacggg caattacatt ctgagattgt
     3241 gatgcagaat cgcctttttt ataggttata acaagtgaaa aaattctgta attgtcgctg
     3301 ttaaaatggt caagcggtac aataccgccg cggtatgatt tattgctggt acagttcaca
     3361 tttgttacat aaccgtaaga tgtttttcct gttgtgtcct taccgtttac attttcgccg
     3421 ttgtactcaa gttcatagct gtcggaggac acgcctgcaa gctgagccgc cttttcggca
     3481 gttgattttt tggcgagaac ataaccgtac tcaggtcttg tttctgttcc gtcaagcttg
     3541 tcaatatcag aaagcagttt ttcgctgaaa gatgtaacaa aacgcaatcc tgatttatca
     3601 aacgacgacg gttttacagg atagttgtcg tcatcatccg catttcttat ctgcgttccg
     3661 aaaaggtcaa atccgcaata actgctcaca ccgattttgt catcatcttt agccttgctg
     3721 actgttccga tatcaatcca atgtgcgtaa acatcggcat ctgtaacaaa ctttgtaccg
     3781 ttaaactgaa tcgggtttga atcgtcatca ttagccttgt tacggtacca acccttaaac
     3841 accattctct gtgagcctgt accgattact tcgggaatat cataaaaagg actgactgtc
     3901 ttatcggtat taagggaacg aactgtttcc atttcggcag cattgtcata tgccggaata
     3961 taacttacat aaacatcgtc atttgcattt gcaagagttt ttaagggatc gtttatgtga
     4021 aaacggatcc tgtagtcatc atgctcaaac cttgcataca gaattgttga tgaatcgtca
     4081 acagtatagg tatgacttgt tctgttattg atatatgctt ctccgtcagc agttttttca
     4141 taccaaccga caaatctgta cccatccatt gcagttgctg tggcggttac ggttttatcc
     4201 ttgaacgaat aaaatgtctt gccgtaatct ccaatatcag aaaaattgta catatcatcg
     4261 gttttattca cagtgacatg accgccgttt gagctgttga catatgtacc gtcattctgt
     4321 tttgtctgtg caataacatc atgcttgaaa taccaccttg ccttgaacac ggcaccgttg
     4381 cgggcatttg ttgttattgt ctttttccga ttagttccgg caagcgtacc cgtaattaca
     4441 aagtcaaggg tttgaggttc aacgcttccg tcatagttat aggttacatt aacatcagaa
     4501 ttgaaaacag ttgcgttatc atccgaaccc gggctgacat attcccaacc gtaaaaatga
     4561 gttccgctgt cagaatcttt ccaattacaa gccgttgcag tatagttacc tgattttttt
     4621 tcgttgaatc tggcaacatt taccgtatca tcaagaacag aaaatcccgt accactaccc
     4681 ttgtctttaa cggaatactt ttctcctccg ttggaaagat atgttactgt ataaatctcc
     4741 gagaaaaaca gttcaactgt aactctgccc gaaatatttt caaagttata tttataacaa
     4801 gcattcccgt cagcatcggt ttctcttgta aattcttcac ttttcagata cctgcgttca
     4861 ccgttgattg ttacatatga gcctatgaac atattcggaa tcttgcggtt ttcaccgtct
     4921 agtcggaaat tgccattgtc gtcctttgca aatgaaggtt ttgcggtaat ctcaagttcg
     4981 gtattgtcat ctaccataat ttcaagcgga ttgttattgc tctgaggagt aatctctaca
     5041 ttcgttttcg aaccgttttg tgtataggta actgttcccg taccgcctgt gtttacaatt
     5101 gtttctgcag ggtgatataa atcgaatgta ataccgtcaa gcaaattacc aaaagtatta
     5161 tgcctatcgg gtcttgaatt ttttgcatca gttccctgat atgaaacaaa agcaaatatt
     5221 gattgattac tgccttccgg aacgatatat ctataataat cgcttgactc ggcggtttcc
     5281 gaacccttgc cgtacttatg ccattctctg ttgttgcttt taattatcca gatatgccat
     5341 tcctccgaaa aaacatcggt ttgggtcaag ctgaagttcc tgtccgacgc attctcaaaa
     5401 gtaccgtttg aagcaaactt ttttgaatag acaacacatt caatcggctt atcgcccgac
     5461 tgttgatttt taatcttttc agaagttgac tcgtcctcgt tatttttgag ccagtcaatc
     5521 atctgcataa actgatccct gctgtttttt gaagccttag tcggattgta gctctgttta
     5581 ggaccgataa caagagccat tgtatctgtt ccgcatctgc cacggtgctg gaggctccat
     5641 tcatagcagc tgccggaact tgtattaata tactgataca aggtactgtc ctgctcggca
     5701 ttaagttccg ccgcctgcaa ttcgtcagga ggagtaaggg tcgtcccttg aagatcggta
     5761 ttctcgataa gatcctttaa gtatatatta ttttctctta ataattctat cctttcatca
     5821 gttgcagatg tactccagtt tggaacattg tcatgatcca cttgatcata atttttttca
     5881 cctatcgaag ggttttcaaa actgccgttc tgaagattgt tcgttgcgtc acttgttttt
     5941 tctaagccgg aaccgtatgt atcaatgtca tcgttatcaa cagcagaact tgacacaacg
     6001 gctgccgata ctgctattgt acacgccaaa acaactgaca agtatttttt aaattttttc
     6061 atataatcac ctcaaaattt accctttata cccatattca tacttatcgg ctatagttta
     6121 tcacaccata aacaacaaaa gcccaacaaa tttaaacaag tgagatatta aaatgtgcaa
     6181 gcttccgtta attaattgaa atttaccgtt gatttttcca ttttattatc ttataatgta
     6241 attatattgt taaatttgtg gtatcggaag gtgaagggat tgaaaaactc accctatgca
     6301 acagtagaaa gatttgttga ccgtttactt ctcggaaaag aaacggactg tgaagccata
     6361 cgcaaatatg aaatatatct tacttacgac aacattataa atatgagtat gtactgcaag
     6421 gctcttattt tagtgctgtt tatgtgtatg gttttccgca gtatattaca cggagtcaac
     6481 gaagttaata ctgtgccctt tgcgattgca acgatgataa cacttgtgat aatgttcttt
     6541 ttaaaaaagt atattgatcc gcaaaatcac actgttaaga cttcacgaat acttacatat
     6601 gcttattcaa ttaacatttg tgcaatagcg atgtattacg accttattct ccagcctgaa
     6661 gaatacgatg tgtttttatt gatagtaata gtcgtgctga gcggtatgtt caacaaacat
     6721 ccgtgtgagc atcttgtttt tctgatctgt ctgttaggca ttttgattgt aatagaagca
     6781 cgccttgcac cgagcaagat ttttttaacc gatttgttca atgcaataat tgcggcagct
     6841 gcaggaatat ttcttgcggt tgcagagatg aggacaaaaa ttgagcttat tatgataaaa
     6901 gaaaacgagc ataaaatcaa aatgagcgac atcaaaactc aaattgtgct taatcaaatc
     6961 aagccgcatt ttctctacaa tgttcttgca accattcagg ttttatgcaa gtttgatccc
     7021 gacaaagccg ttacggcaat ggaagatttt tccggttatc tgagagccaa tgttgactac
     7081 ggactttcga aaagtgttgt ttcgtttgat gaagaattta aaaatgtcca atacttttta
     7141 aggcttgaaa aactccgctg cggtgacaag cttaagattg tgtatgagct taaagaaaaa
     7201 aattttgaaa ttcccgtact cacccttcaa ccgattgttg aaaatgccgt taaacacggt
     7261 gtaggcaaca aaaaaggcgg cggaacggtt actatctcta catcaagcga tgacaacaat
     7321 ataataatca gagtgcagga tgacggggat ggaatttccg caaagtcaat tgatgagctt
     7381 tcgctttcat atgacggaaa aagtcatgtt ggacttacaa atgttaagga aagaatagaa
     7441 atcataacgg gcggcagtct tgatttttac agcgaaaaag gcaaaggaac tgttgtcacg
     7501 ataaaaatac ctaaagattt taaagaggct acttatgaat atactcgcag ttgatgacga
     7561 acctataatg ctatggtcac tgaaaaacag tcttaaaaag atatttacta aaaatgacga
     7621 ttccgtaaac ggttttgatg aaattgatga cgcaatgaat tatgttgact cactgggcaa
     7681 cgagaaactt gactatgcct ttcttgatat aagactgaga ggaattgacg gaatcaattt
     7741 tgcaacactc ataaaggaaa agcaaccggg agtgaaaatt gtattctgca cggcttattc
     7801 cgacaaggcg cttgacgcat ttgaagtcaa tgcaatagga tatcttctca agccgattac
     7861 ggaagataaa ataagaaatc ttctcaagca gattgaatat atgttcaaag acagcgacga
     7921 aagagcccat attgaagtta agacttttgg aaattttgat gtgtttgttg acggaaaggc
     7981 cgttatatgg cacaggcaaa aggccaagga gctgcttgcg tttttgattg acaagcgagg
     8041 cacatcggtt acaaacagcg aaattgcgct tgcactatgg gaaactgacg caaatgttaa
     8101 aagtgtggca acaatcatct cgtcacttcg cagcacactg aaagaatacg gaattgaaaa
     8161 gattcttgtc cgttcaagaa acagtacagc gattgacaca actaaactga agtgcgatgt
     8221 ctatgatctc tacaacggaa gtaaagaggc aaaaaacctt tataacggcg aatatatggc
     8281 aaactacagc tgggcggagt ttacaaacgc ccacctcatt gcctacacag gatataattt
     8341 taaaaaaaaa taacagcatt ttaaaatttt caagaattac tctcaattcg ttggtctttt
     8401 gttgtacttc atatgctatc atacccatgt aataggataa gggtggtggc ttatgcagag
     8461 agttgttaca aaatttttga ccatatttat gtgttttatt attttactgt tgacattttc
     8521 ggggtgcggt aaaaatcggg ataacggctc ttctgcaata agttcatctg caactcaaca
     8581 aacagtttcc gaatcatcat caagcggttc ggatgatgtt gaggttgatt tttccgattt
     8641 gcagtaaatc ggagtatatt gggttttaga aggagagttt tttatgaaaa aaattgcagg
     8701 tgtgttactc gcatgtataa tttgcctctc tgctgtattc tgcattgggg ttagtgcaac
     8761 tgaaattaag cttggtgatg tgaacaatga cagcgttatc aatgtcaaag acgcaacgct
     8821 tattcagaag catatctgca atgttgaaaa tcttaacgga gaagcacttg ttgcggctga
     8881 tgttgacaaa aacgggctta taaatattac cgacgcaacc tatattatga cattcgtcgt
     8941 ttcacttatc gatgaatttc cgaacgaacc aaagactgag ccttcaacag aaaagacttc
     9001 tttgtcaacg gattcggaag gttactacaa tgttgttgtt aagccgtaac ggttttatga
     9061 tttcagattg aataattcgg cagaggtttt tatgaaagat acatacgaaa agattgaaat
     9121 tgaaattaaa gaaataaatt gcgatgatgt gattgcaaca tcatcaccga caacatctca
     9181 gaaagagaac gcatatttct catttgacga tttgttcggc gatacatatt ttgattaaaa
     9241 ggaaagcctt tatagttttt gctataaggg ctttttctaa gcaaggattt tattatggct
     9301 gtttacaaaa ttgctgacat aaatataaaa attaactgtc acggaaatta tcttaaaaat
     9361 ctgctcaaaa actacagatg tgattatacc gactatgatt ttgaggttgt tgcgacagat
     9421 aatgacatac aggctgaaaa aataatagca gacggtttcg gcgatgaaat gtacgaatca
     9481 tctgccgttt taagaaaaat aagtgaaaaa ctgctttatg aatatgacgg aattcttttt
     9541 cacggagctg ttatagaata caaatcgaag gcatatctgt tttgcgcacc atccggaacc
     9601 ggaaaaacaa cacacattat gctctggaaa aaatatttga aagatgaagt aactattctc
     9661 aacggggaca aaccctttgt cagaatcatt gacaatgttc cgattatata cggttctcct
     9721 tggagaggca aagaaaacct tggcaaaaac gatttctgca agcttgacgc tattgttttt
     9781 gtaaacagga acaaacaaaa ttttgcaaga cacctctccc ctgatgaatc gcttttcaga
     9841 ctgctttcat gcacggcata tcccaaaaat tccgttggaa agttaaaaac gcttgaattt
     9901 cttgaaaatc tttctgcaaa aatcaaattt gttgaccttt tttgtaatat ggaatataat
     9961 gcttgcagga ctgcattaaa tgcactcacg gaggaaattt atgaaaatta aaaacggatt
    10021 tattctgaga aatttttccg acaaaattgt cgctgtgccg gaagatgact ttgccgataa
    10081 cagcaacctt ttcatcaaga tgagttcaag tgctgaattt gtctggaatt ttctgcaatc
    10141 cgacaaaaca tacgaagagg ttttagatgc gttgcttgaa aaatatgata ttgacaggca
    10201 gacggctgaa aatgacctga ataactttct ctcaactgta agaaatgcgg ggttacttga
    10261 tgagcagtcc tgaacaaatc attgaggaat acggttttta ctctgcacct gttcacggaa
    10321 tgagtatgta tccgctcttg aaaaatcaca gagacgctgt ctgtattctt ccgcccgaca
    10381 agctgaagaa gtacgatgtg gtgctgttta ggcggcaaag cggtcagctt gtacttcata
    10441 gaatattgaa gattgacggc aatagatttt acatatgcgg cgataatgag ttcagaaaag
    10501 aaatcgttta caaaaatcag attatcggca agatgacaga attttgcaga aacaataaaa
    10561 acggtaaggt aacggatttc aaatacaaaa tctattcata ctgttggaac tcatcgtttc
    10621 tcatcaaaag aatactcctg cgcatctatg caaaattttt caaaggttaa tatgaacaaa
    10681 tcacttataa ctgtagggac tgccgtgtgc agactgatag gacaatttac aaataaaaat
    10741 attcatataa acaaaaacag cttgccgcct gttcccacaa tggtcaagtt tgcaaagatg
    10801 cacagcattg aaactatgct ttatgcaggg ttaaaaaaga gcggtttcac tgatgatgaa
    10861 ctcggggatt tgccggagca ggcagaattg ctttcgtttt gtcagataaa aaacgacgcc
    10921 tttgcggcaa gattgtccgc aaatttttca aacgccggca ttgaacatat gattattaag
    10981 ggcatagagt tttcaaaata ctatccgccc aaacttctgc gaacaagcac cgacattgat
    11041 ttttatatgt cgggcaaaga tgccgaaaga gttgcccgag gtcttgaaga acgaggattc
    11101 acaagaatcg aagacgattg taccgtaata gcacttgcaa aaaagccatg ttcgcacatt
    11161 gaaattcaca taggatttaa tgcggtgaat aaaaagcagt caaaatttta tgccgatttg
    11221 cttaaaaatg cgcaatataa aaataacagc agaagatatt tttcagaaga aaacaatctt
    11281 cttttcgctc tgcttcactt gtacaaacac ttttcaaaga gcggtgcagg cgtgagaatg
    11341 ttgcttgaca tatatcttat tcagaaaaaa tgtatatttg acatagaatc cattcaaaaa
    11401 aagacagccg atttgggaat cgataagttt tttaattctg tatgcgaaat atcagattat
    11461 ctttttgaag gaaaaagtct tgacaatcgg atgtttccgg ctctggaatt tttcttcagc
    11521 agcggtactt tcggcacaaa tgacgcatat ctgacaatca atgctgcaaa atacagcggg
    11581 aaaacttcca aaataaagaa ttatctgaaa agtgaagcag gcttttcaaa tgaaaatata
    11641 aagaacaaat atccgcttgc aaagaaattt ccggtgctac tcccctattt ccatgttcac
    11701 agggtggttt caggatttat tcataagggc aaatcggtcg gtcgtgtcat aacagatagc
    11761 aaggttgtga cctccgataa cgctgcaaaa caacttattg aagttatgga gcttatggga
    11821 ataaactgag cacagcacat ctgacacgaa aatttaagga gctgtgaaga aatgaagttt
    11881 aagacttcgt tcttcgcagc tcctttgttt tttgtgaaat aataatgcaa ttgttaaaaa
    11941 agcatacttc caccctgaat attgttcaaa acaagcactt ttttcaccct actcgattag
    12001 ccccaacata accgttgaaa aatcgggcaa cagaaatttt gcattttaca aatctattgc
    12061 ccgacctgaa ttttaaactg tcaattttta ttttgctaaa agcttaaatc ccataataac
    12121 aacacctaac accacgagga cgatacctgt agcacgatta agggttttgg gcttagcttt
    12181 gtttgcaaag acggcggcaa ttctcgccca tataagggtg aacgctatgc agagaatgaa
    12241 cacaaaccaa tcgggtgtgc caccaatcat aaagtgcgaa gctgcgcctg tcagggcggt
    12301 gaatgtcata atgaatacgc ttgtgccgac agcggttttc aattcatagt tcagcacggt
    12361 cgtcaaaatc aaaagcatca tcattcctcc gcccgcacct ataaatccgc agataaagcc
    12421 gattaacatt ccgcagatta cagactggat tgccctcttt tttgccgaca caccgagcat
    12481 agcttcttta gttgtcataa cgggacggat gataaatttt atgccgagca aaaatgtcat
    12541 aaacacggaa aatcctccca ttgtagctga tggaacaatg cttgcaacat aactgccgac
    12601 aatcgtaaac gcaagcacac tcgccatcat aatcaaaccg tttctgacat cgagattttt
    12661 atttttatgg tatgtataag ccgaaactgc actcgccaaa acatcggacg aaagtgcgat
    12721 tccgactgcc atatacggat ccatattaag aaaagttatg agcatcggac ttattacagc
    12781 cgccgcactc attcctgcaa aacctgttcc gagacctgcg cccattcctg caaaaaatgt
    12841 aactaaaatt gtaataaata tatccattta atttcctcta tagaataata taactaaatt
    12901 aagattattt taattttgcc gtttcataaa caaaagccgt gaaatcagca ttattaccgc
    12961 agttccgaca agtatctgca acgggtacaa aagtacgctt tcactcggaa taatcatact
    13021 caaaattgtc aatgctccgg caggcggaat atacattttt gtgcagtaaa caataacaag
    13081 cattatcgcc gtggctgtca atgcggcaac tgtcaacggc aatccgagag tcatattcag
    13141 cacatatctt gaaaccgctc cgacaaatgc acagactgtt atcagcaaaa ccgtctttac
    13201 cggcttgttg cgagccttat ttttcggacg ggaaaattcc gtaaacgcca caagcaacgg
    13261 cggtgcaatt gcaaatttaa agcccgacca aattgcgaag aatcccacaa cggcaacaca
    13321 gattgttctt acggctgtgt caatcacatc gctctttgca tgcaggttta ccgactgaaa
    13381 atcctcttta tctcttattt taactttcaa aagaaatctg cggaataata caaccgcaat
    13441 tgtcagcaaa aatgcagcaa tcgggtatat aaagctctcg gtctgcatca taacgggcaa
    13501 cacaattgcc gaaatcatcg gtgcaaatgt tgttcccgaa aacataaaga gaatttgtgc
    13561 aaatacaaat gcaatcaata tttcaagata aagcccgact tttatgtatc ggactgtcag
    13621 cacacccgca acagcgcaaa tcgcaattaa cgcaatcatt cggctgtcat tgactttcca
    13681 accttgcttt tg
//
