LOCUS       c00186_gnlPro..        14672 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MJCLAJGF_186.
ACCESSION   c00186_gnlPro..
VERSION     c00186_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 21:08:53
            Original ID  :: gnl|Prokka|MJCLAJGF_186
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14672
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14672
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:4672]"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..4672
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
     cand_cluster    1..14672
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /kind="single"
                     /product="Rnf_complex"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14672
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Rnf_complex"
                     /region_number="1"
                     /rules="(Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4,
                     Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))"
                     /tool="gutsmash"
     CDS             complement(2..538)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_1"
                     /sec_met_domain="Rnf-Nqr (E-value: 5.9e-70, bitscore:
                     225.9, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNFKVLMNGIVKENPTFVLLLGMCPTLGTTSSAINGMGMGLATM
                     FVLICSNVVISSIKNLIPDMVRIPAFIVVIASFVTLLQMIMQAYVPALYATLGLFIPLI
                     VVNCILLGRAEAFAAKNGPVPSFFDGLGMGLGFTLALTILGGVREFLGTGKLFDIAIMP
                     EQYGMLIFVLAPGAFI"
     CDS             complement(553..1317)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FMN_bind"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_2"
                     /sec_met_domain="FMN_bind (E-value: 3.7e-22, bitscore:
                     70.0, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVIVLTGVTVVAGALLGYVNELTKEPIAQANAKALSDAIAIVVPG
                     FDNNPAEAPETIELEGVTYKIYKATKGGEFIGAAVESSANGFGGALNVLVGFDKEGNII
                     DYSLLSHAETPGLGSKAADWFKKGGKGDITGMNPGQKALVVNKDGGQIDAITASTITTR
                     AFLKAVNNAYAAYSGQNVDGSSGATQQVSETAADDPKAAKAQCEGTQDCCGQACDSAAC
                     KAACGGKCDPANCDKADCKKAECPKQDCKNKK"
     CDS             complement(1344..2333)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: NQR2_RnfD_RnfE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_3"
                     /sec_met_domain="NQR2_RnfD_RnfE (E-value: 3.4e-120,
                     bitscore: 391.9, seeds: 472, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANKLIVSLSPHVHSGDSIQKNMYGVLIALIPALLVSFYMFGLGA
                     VVVTLTSVAACVFFEWAITKFILKRERSTICDGSAIITGVLLAFNLPSNLPLWIIIIGA
                     LVAIGVGKMTFGGLGCNPFNPALVGRIFLLISFPVQMTSWPLVQQWGSYTDAETGATPL
                     ALMKMAVKGDANALGQLPDTLSLFLGNNPGSLGEVSALALLLGLGYMLWKKIISWHIPV
                     SILVTVFVFAGLMHLVDPVAYASPLAHLFTGGLMLGAIFMATDYVTSPMTHKGMIIYGV
                     AIGFLTVVIRLFGAYPEGMSFAIFIMNAFTPLINTYCKPKRFGEVVKK"
     CDS             complement(2348..3277)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: SLBB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Complex1_51K"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_4"
                     /sec_met_domain="Fer4_7 (E-value: 3.8e-09, bitscore: 28.3,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="SLBB (E-value: 1.9e-17, bitscore: 54.1,
                     seeds: 67, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_51K (E-value: 5.2e-49, bitscore:
                     157.2, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.7e-05, bitscore: 16.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGACFPTHVKLSPPPGCKAECVIINAVECEPYLTADHRLMLEKA
                     DEVLVGVSILMKAAKVTKGYIGIENNKPDAIKLMTEKAAQYPGIEVVPLQVKYPQGGEK
                     QLIDAVIGRQVPAPPAIPINVGAVVQNVGTAFAVYEAVQKNKPLFERIVTVTGKSVKNP
                     SNFLTRMGTPMSQLIDAAGGLPEDTGKVIGGGPMMGKALVNTEVPICKGSSGVLIMNDK
                     EAARAEAQPCIRCAKCVSVCPMGLEPFLLATLSAHKDWERVEKEDVMSCIECGSCQFTC
                     PSHRYLLDYIRLGKGTVGGIIRARNAKK"
     CDS             complement(3725..4672)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FeS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_17"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1016:4Fe-4S dicluster domain (Score: 40.3; E-value:
                     1.2e-12)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_5"
                     /sec_met_domain="Fer4_7 (E-value: 6.7e-13, bitscore: 40.3,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 5.7e-10, bitscore: 30.0,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_2 (E-value: 1.4e-08, bitscore: 25.8,
                     seeds: 214, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 8.8e-09, bitscore: 26.5,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_17 (E-value: 1.1e-07, bitscore: 23.5,
                     seeds: 82, tool: rule-based-clusters)"
                     /sec_met_domain="FeS (E-value: 3.1e-10, bitscore: 30.8,
                     seeds: 364, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.1e-05, bitscore: 15.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLILVAVISLGAIGLIAAVILYAASKKFAVYEDPRIAKVSEVLP
                     QANCGGCGYPGCSGFAGACVKAADAGSLEGKLCPVGGAPVMEKVAAILGLEAVAAEPKV
                     AVVRCNGSCENRPRTALYDGAKSCAIAHATSGGETGCTFGCLGCGDCVEACQFDAIHMN
                     PETGLPEVDEEKCTACGACSKACPRKIIEIRPKGKNNRRVVVMCVNKDKGAVANKACKA
                     SCIGCGKCVKVCPFEAITLENNLAYIDPAKCKSCRKCESECPKGAIQAINFPPRKPKVE
                     VPAGEAAAKPAAKVEASKVETPEAVKAEAPKAEA"
     CDS             complement(4693..4965)
                     /locus_tag="ctg186_6"
                     /transl_table=11
                     /translation="MKASSYRIGEEVMIYGTTSMGMQAVLLAFGIPFLVLLITLFISMR
                     FTGGDELRSALVALSALLPYYLIIYVCRNKLSKKFSFTLEPIKNN"
     CDS             5219..6019
                     /locus_tag="ctg186_7"
                     /transl_table=11
                     /translation="LCGEIKIRNKKGRKILNSPLSTCKVYNLFHYHIACIQQFLTNGCY
                     MFLVSGFHNDTKGTSGDICTLTISLMMYRNYISSLLCDNFADSQQLPRFVYQVQSYCIG
                     TSRLCHTATDDTAQYRHINITSRHQANSFLTLYRYLIEHGCSNGHSSRPLCNNPLAFYQ
                     CQNSCGNLILGHSYNSVHILINQVKSICSRLFHRDSIGKSGNRVKTLNTRMKNRICHTG
                     RTQRLYTIYLDRRFQSLQRISHSRNQSAPTNGDNDYLHIRHFLQ"
     CDS             6167..6487
                     /locus_tag="ctg186_8"
                     /transl_table=11
                     /translation="MLRSLNFRYRCSLWKTNQRLDATLSGSQCHPLRMITGRTGYHTSR
                     LFFIRQLGNLVISTTHFKRSCELQVFGLQINCTLRIYLRSINQISATDNLFQDMSRLVY
                     CI"
     CDS             complement(6677..7597)
                     /locus_tag="ctg186_9"
                     /transl_table=11
                     /translation="MNKQVEANLSMVVSKALGGLNMNALKYLLPLWIAPVTGVTFRLVF
                     GAAAFWLIDIFCKPENSTIRQKWQLFMLGALGIYGYMFFYLLGISKTTPVSSSIFVSLE
                     PIWVFIIAVLFYKEKVTWMKVLGIGMGLGGAILCISTQPSDDLASNAPLGNLMCLVSSL
                     VYAVYLVLSNRLLKGVGNMTMLKYTFLGAAVMAVIVNTIYGFDAPILRMSLFSTPMLVL
                     LFVLVFPTTISYLLLPLGLKYLKTTLVAIYGYLILIVATVTSFILGQDRFSWTQLAAIV
                     LICASVYLVEVAESKSEKQIISKSR"
     CDS             complement(7629..8819)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 54.4; E-value: 3.1e-17)"
                     /gene_kind="transport"
                     /locus_tag="ctg186_10"
                     /sec_met_domain="MFS_1 (E-value: 1.7e-17, bitscore: 54.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVQTGQGTIPLITLIGIFSISALNALPGLAVSPILGDLNKIFPS
                     ATDLEIQMLSSLPSLLIIPFILLSGKLTEKVNNLLLLQIGLAIFGVSGILYLLSNKMWQ
                     LIAISAMLGIGSGLIVPLSTGLISRYFVGAYRTKQFGYSSAITNITLVLATTLTGYLAE
                     VNWHLPFLVYLFPFISIFLTHYLKKDLSSYHPSDDIPSDTAKEMGKRGMNVKALIKLMA
                     FYGLATYLVIIISFNLPFLMEEYGLSSGRAGILISLFFLAIMAPGFVLNRIVQVLGRRI
                     YMVCLLMIACGMGIILLSRSEILIALGCVLNGLSYGIIQPLIYDKTSDVAVPHKVTLAL
                     AFVMAMNYVAILLCPFIVDAFQNLFHSHSQTFAFWLNLMVALMGMFIVMKQEKLSL"
     CDS             9327..10709
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyridoxal_deC"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg186_11"
                     /sec_met_domain="Pyridoxal_deC (E-value: 7.9e-68, bitscore:
                     219.9, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQPAPVDTIPMEPTTPQIAYQMVKDETFAQTQPRLNLATFVTTY
                     MDDYATKLMNEAININYIDETEYPRIAVMNAKCINIMANLWNSPEQAKWKSGALAIGSS
                     EACMLGGVAAWLRWRDRRKAQGKPTDKPNFVISSGFQVVWEKFAQLWQIEMRQVPLTLD
                     KTTLDPEEALKMCDENTICIVPIQGVTWTGLNDDVEALDKALDAYNAKTGYDIPIHVDA
                     ATGGFILPFLSPETKWDFRLKWVLSISTSGHKFGLVYPGLGWVVWKDKKYLPDAMSFSV
                     NYLGANITQVGLNFSRPAAQILGQYYQFIRLGFQGYKAIQYNSMEITKYIHSEIAKMAP
                     FVNYSDKVVNPLFIWYMKPEYAKNAKWTLYDLQAKLQQSGWMVPAYTLPENIQNYVVMR
                     VVVRQGFSRDMADMLLNDIKNAISEFEKLEYPTPTRIAQDKNIAVKGTVFTHNAHSNAA
                     KK"
     CDS             10775..11737
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glutaminase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg186_12"
                     /sec_met_domain="Glutaminase (E-value: 2.4e-97, bitscore:
                     316.6, seeds: 316, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERTITIQQIKDAAQEAYNLYKDNTDGKNADYIPYLANIDPKLFG
                     ISICLMNGEIIQLGDSQYRFGIESVSKVLTAILVLRQYGAPKVLEMIGADATGLPFNSI
                     MAILLENDHPSTPLVNAGAISADSMVQPLGNSDGKWKAIVDNMTELCGSAPQLIDELYK
                     SESATNFNNRSIAWLLKNYNRIYDDPDMSLDLYTRQCSMGITAEQLSICGATIANEGLN
                     PNTNKQVFDKALAPKITSMIATVGFYQHTGDWLYTSGIPAKTGVGGGVMGVMPGVMGIS
                     AFAPPLDDAGNSVKAQLAIKYIMNKLGMNVFNGHRIHVQ"
     CDS             11911..12033
                     /locus_tag="ctg186_13"
                     /transl_table=11
                     /translation="MDELMQRNHLWSPSGDIERKLLKQPKAPDDVSYVIELTIK"
     CDS             12272..12901
                     /locus_tag="ctg186_14"
                     /transl_table=11
                     /translation="MLHDIKVARQLGADGVVFGCLTAEGNVDVPLMQKLMNAVGEMSVT
                     FHRAFDMCSNPKEALEQIIGLGIDRVLTSGQEATAEKGIPLLKELVELADGRIIIMPGC
                     GVNAGNIRKIAEETGTSEFHFSGRSSVDSGMIYRNSKVSMGGTVKIEEYLKDVTDPNKV
                     KAALSELALKDENDKALEKKNKSLNPKKSKKEDDWDDDDDDLDDDK"
ORIGIN
        1 caatgaaggc tcccggtgcg agaacgaaaa tcaacattcc gtattgctcc ggcataatag
       61 cgatatcaaa caatttacct gtaccaagga actcacgtac accaccaagg atggtcaatg
      121 caagtgtaaa tcctagtccc atacccaatc cgtcaaagaa tgaaggaaca ggaccgttct
      181 ttgcggcaaa cgcttcggcg cgtcccagca agatacagtt taccacaatc aacggaataa
      241 acaatcccaa agtagcatac agcgccggca catatgcctg cataatcatc tgcaacaagg
      301 ttacaaatga tgcaataacc acaatgaatg caggaatacg caccatatca ggaatcagat
      361 tcttgataga tgaaattacc acattcgaac aaatcaacac aaacatggtt gccagtccca
      421 tacccatacc attgatggca gaagaagtgg ttcccaatgt aggacacata cccaaaagga
      481 gtacaaacgt aggattctct ttgacaatcc cgttcatcaa tactttaaaa ttattcatag
      541 tctgctcctt ccttattttt tgtttttaca atcttgcttt gggcattctg cttttttaca
      601 gtccgccttg tcgcagttag caggatcaca tttaccacca caagcagctt tgcaggcagc
      661 agagtcacag gcttgtccgc aacaatcctg agttccctca cattgtgcct tagctgcttt
      721 ggggtcatcg gcagcagttt cagacacctg ctgtgtcgca ccgctggaac catccacatt
      781 ttggccacta tatgccgcat aagcattatt cacagctttc agaaaagcac gtgtcgtgat
      841 agtagaagca gtgattgcat ctatctgacc gccatcttta tttacaacca atgctttctg
      901 tcccggattc ataccagtaa tatcgccttt gccgcctttc ttaaaccaat cggctgcctt
      961 tgatcccagt cccggagttt ctgcatgact caacaaagaa tagtctataa tattaccctc
     1021 tttatcgaaa cctaccaata cattcaacgc accaccaaaa ccatttgcag aagactctac
     1081 ggctgcacca ataaattctc ctcctttggt tgctttatat atcttataag taacgccttc
     1141 caattctatg gtttcaggag cttcggcagg attattgtca aatcccggaa ctacgatagc
     1201 aatggcatca ctcaaagcct tggcattagc ctgtgcaatg ggttcctttg tcaactcatt
     1261 cacataaccc agcaatgctc cggctaccac ggttacgcct gtcagcacga taaccatgtt
     1321 tttcaaagat gattctagtt ttttcatttc ttcactacct ccccgaatct tttaggttta
     1381 caataagtat tgattaacgg agtgaatgcg ttcataatga atatagcgaa agacatacct
     1441 tcgggatatg caccgaacaa acggataacc acggtcagga aaccgatagc cacaccgtaa
     1501 ataatcatac ctttatgagt cataggcgaa gtaacatagt cggttgccat gaaaatagct
     1561 cccaacatca aaccacctgt aaacaagtga gccaacggag atgcgtaagc aaccggatca
     1621 accaaatgca tcagcccggc aaatacaaat actgtcacca gaatagatac aggaatatgc
     1681 caggaaataa tctttttcca tagcatatat cccagaccaa gcaataaagc caatgcactc
     1741 acctcaccta gtgaacccgg gttattaccc agaaacagac ttaatgtatc gggcaactga
     1801 cctaaagcat ttgcatcacc ctttacagcc attttcatca atgccagcgg agtagcaccg
     1861 gtttcagcat cggtataact tccccattgt tgaaccaacg gccatgaagt catctgcaca
     1921 ggaaaagaaa tcagcaggaa gatacgacct accagcgcgg gattgaaagg attacaaccc
     1981 aatccgccga aagtcatctt gcccacaccg attgccacca acgcaccgat gataataatc
     2041 caaagcggca agttggaagg cagattgaat gccagcaaca caccggttat aatagccgaa
     2101 ccatcacaga tggtagagcg ttctctcttc aaaataaact tggtaatcgc ccattcgaag
     2161 aatacacagg cggcaaccga ggtcaaggtc accaccacgg cgcccagtcc gaacatataa
     2221 aatgacacca gcaacgcagg tatcaacgca atgagtacac catacatatt cttctgtatg
     2281 ctgtcaccgc tatgaacgtg aggcgataat gatactatta atttattagc catactattt
     2341 tgtcgaatta ttttttagca ttacgtgcac ggatgatacc gcctactgtg cccttaccca
     2401 aacggatata gtccagcaaa taacgatgag acggacatgt aaactgacac gaaccgcact
     2461 cgatgcacga cattacatct tctttttcta ctctctccca gtccttatga gctgaaagtg
     2521 tcgccaacaa gaaaggctcc aatcccatag gacacacact gacgcacttg gcacagcgga
     2581 tacagggctg agcttccgca cgggcagctt ccttatcatt cataatcagc acacccgaac
     2641 tacctttaca aatgggaact tccgtattaa ccagtgcttt acccatcatc ggaccgccac
     2701 caatcacttt tcccgtatct tcgggcaaac cgccagccgc atcaatcagc tggctcatcg
     2761 gggtacccat acgggtgagg aagttggagg ggttcttgac agacttaccc gtaacagtca
     2821 cgatacgttc aaacaaaggt ttgtttttct gaacggcttc ataaacggca aatgcagtac
     2881 ctacattctg aactaccgca cccacattga taggaatagc gggaggagca ggaacctggc
     2941 gaccgatcac agcatctatc aactgtttct caccaccttg cggatatttc acctgcaaag
     3001 gaactacctc tataccggga tactgagcag ccttttcagt catcaactta atagcatccg
     3061 gtttattatt ttcaataccg atatatccct tggtcacttt tgcagctttc atcaggatgc
     3121 ttacacccac cagtacttcg tctgcctttt ccaacatcaa acgatggtcg gcagtgaggt
     3181 aaggctcaca ctctacagca ttgataatta cacattccgc cttgcagccc ggaggaggag
     3241 aaagtttcac atgagtaggg aaacaagcac cgcccatacc tactacacct gcatttttca
     3301 ctttagcaac gatttcttcg ggtgtgagag cacactcttt caccaatgtc gaactgcggt
     3361 ctattgattc ttcccattcg tcaccatcca catcgataaa gatagccggc ttgcggtaac
     3421 cgcttgcatc gattacggcg tctaccttgt tcactttacc ggatacagac gagaagatgg
     3481 ctgctgaaac aaagccaccc gcctcagcaa tcttcgtacc taccttcacc acatcgcctt
     3541 ttttcacgat ggcagtagca ggagcaccga tatgctgtga caaaggaaat accgcttgct
     3601 taggaagtgc aagggtttca atggctttgc ctgctgacaa tttattttct gctggatgta
     3661 ctccaccaat tctaaatgtc ttcactgtta tatcttttta atttttactt actttgaatt
     3721 ttgattatgc ttccgctttc ggagcctcag ctttcaccgc ttccggagtt tccacctttg
     3781 aagcctctac ttttgcagca ggttttgcag cagcctcacc agccggcact tctaccttcg
     3841 gtttacgtgg cgggaaatta atagcttgga tagccccttt cggacattcc gattcacatt
     3901 tacggcaaga tttacactta gccggatcaa tgtatgccaa attattctct aacgtaatgg
     3961 cttcgaacgg acacactttc acacactttc cacaaccaat acaactagcc ttgcaagcct
     4021 tgttggcaac agctccctta tccttgttca cacacatcac cactacgcgg cggttgttct
     4081 ttcctttcgg acgaatttca atgatcttac gcggacaagc tttgctacaa gccccacaag
     4141 ctgtacattt ttcttcgtcc acttccggaa ggccggtttc aggattcatg tgaatagcat
     4201 caaactgaca cgcttccaca caatcaccac aacccagaca accgaatgta caacccgtct
     4261 caccacctga agtggcatga gcgatggcac acgatttagc tccgtcatac agagcagtac
     4321 gagggcgatt ttcacaacta ccgttacatc ttaccaccgc aactttcggt tcggcagcaa
     4381 cggcttccaa tcccaaaatg gcagctactt tctccattac cggagcacca ccaaccggac
     4441 ataacttacc ctccagcgaa ccggcatcgg cagccttcac gcaggcacca gcaaaaccag
     4501 agcaaccggg ataaccacat ccaccgcaat tcgcctgagg aagcacttcg ctcaccttgg
     4561 caatccgcgg atcttcatac acagcaaact tcttagaagc ggcatacaag attaccgcgg
     4621 caatcaagcc aatcgctccc aacgaaatta ctgcaaccag aattaaatcc ataaatttta
     4681 gttagttatt tattaattat tttttattgg ttcaagcgta aatgaaaact tcttgctcaa
     4741 cttattcctg catacatata tgataaggta atacgggagc aaggctgaca aagcaacaag
     4801 cgccgacctt aactcatccc cccccgtaaa acgcatggaa ataaataaag taatcagcaa
     4861 taccaagaaa gggataccaa aagccagcaa tacggcttgc atccccatgg aagtggtacc
     4921 ataaatcatc acctcctcac ctatgcggta agaagatgcc ttcatgtcaa aaacatcaat
     4981 cagtttctct ttactttcag atgcattgca atgccctttc acactacaag ccgaacaggc
     5041 agaagtttgt acgattctca cccgcacatg agaaccttca atgttttcca caataccacg
     5101 atgtttgatt atatcggtca tttttgcaaa ctctacatta caaaactgcg gcaaatgtac
     5161 gattttaatt ggattctaag aagtataaaa tgatattttc actataaaaa tcgatttttt
     5221 gtgtggagaa attaaaatta gaaacaagaa agggaggaaa attttaaatt cccccctttc
     5281 tacttgtaaa gtatataatt tatttcatta tcacatagcc tgcatccaac agtttttgac
     5341 gaatggatgc tatatgttcc tcgtttctgg tttccataac gacacgaagg gcacatccgg
     5401 tgacatctgc actctcacta tttcgctcat gatgtacaga aattacattt cctccctgct
     5461 ctgcgataat tttgctgact cccaacagct gccccggttt gtctatcaag tccaaagtta
     5521 ctgcataggt acgtcccgac tttgccatac cgcgactgat gacacggctc aatatcgtca
     5581 catcaatatt acctccagac accaggcaaa cagttttctt accctttacc ggtaccttat
     5641 tgaacatggc tgcagcaacg gacacagctc ccgccccctc tgcaacaatc cgctggcgtt
     5701 ctatcaatgc cagaatagct gcggcaatct catcctcggt cacagttaca attccgtcca
     5761 catactgatt aaccaagtca aaagtatttg ttcccggctc tttcaccgcg attccatcgg
     5821 caaaagtgga aacagagtga agacgctcaa tacgcgaatg aagaatagaa tttgccatac
     5881 tggccgcacc caacgcctgt acaccatata ccttgacaga cggtttcaaa gccttcaacg
     5941 cataagccac tcccgaaatc agtccgcccc caccaatggg gacaatgact acctccacat
     6001 ccggcatttc ctccaataac tccaaaccga tagtaccttg tccggctatc acattctcgt
     6061 catcaaaggg atgaacaaaa gtatatccct tttcatcacg taattgcaga gctttctgat
     6121 aagcatcatc atagactccc ggaaccaaac aaacttccgc cccataatgc ttcgtagcct
     6181 caactttaga tataggtgct ccctctggaa gacaaatcaa cgacttgatg ccacacttag
     6241 tggcagccaa tgccacccct tgcgcatgat taccggcaga acaggctatc acacctctcg
     6301 ccttttcttc atcagacaat tgggaaatct tgtaataagc accacgcact ttaaacgatc
     6361 ctgtgaattg caggttttcg ggcttcagat aaactgtact ctcaggattt atctgaggag
     6421 cataaatcaa atcagtgcga cggacaacct ctttcaggac atgagccgcc ttgtatattg
     6481 catctaattg tagcataggt ataacactct tgttttttaa ttgggtgcaa agctacaaat
     6541 aaaattgatt ccttacactc gctttcgatg taaagttgca ttcttttttt tcgctcattc
     6601 atttgccggt aagtttcttt acattacaca ccgcgataat ttttttctta gggtcttata
     6661 cttttttccc ggtgtcttat ctggatttcg atataatctg tttttcactt ttactctcgg
     6721 ccacctctac cagataaaca ctggcacaaa taagaacaat cgccgccaac tgcgtccatg
     6781 agaagcgatc ctgccccaaa ataaaagagg tcaccgtagc aacaatcaaa attaaatatc
     6841 cataaatagc taccaatgta gttttcagat atttcaaccc gaggggaagt agtaaataac
     6901 taatagtggt agggaatacc aaaacaaaaa gcaagaccaa cataggagta gagaaaagtg
     6961 acattctcag tataggagca tcaaagccgt aaattgtatt gacaataaca gccatgacag
     7021 ccgcccctaa aaaggtatat ttcaacatcg tcatatttcc cacccctttt aacagacgat
     7081 tgctgagaac aagatagacg gcataaacca gcgaactgac caaacacatt aaattaccta
     7141 acggagcatt agaggcaaga tcgtcactag gttgtgtaga aatgcaaaga atagctcctc
     7201 ccaaccccat tccaatacca agcactttca tccaagttac tttttcctta taaaacaata
     7261 cagcaataat gaatacccat ataggctcca aactgacaaa gatggaactg gaaaccggag
     7321 tggtcttact gatacccagc agataaaaaa acatatatcc gtaaatacct aaagccccta
     7381 acataaaaag ctgccatttc tgacgaatag tggagttttc gggtttgcaa aatatatcaa
     7441 taagccaaaa agcggcggcc ccaaatacca atcggaaagt aacccctgtc acaggagcta
     7501 tccacaaagg taaaagatat ttcaatgcgt tcatattaag gcctcccaac gctttggaga
     7561 caaccatgct aaggtttgct tcaacttgtt tattcatact tcatgctgtt attacgtggg
     7621 tatttttctt ataaactcag tttttcctgc ttcatcacaa taaacatacc catcaaggct
     7681 accatcagat taagccagaa agcaaaggtt tgcgaatgag aatggaacag attctgaaaa
     7741 gcatctacaa taaaaggaca aagcaggata gccacataat tcatagccat cacaaaggca
     7801 agtgccaatg tcaccttatg aggtacggcc acatcagagg tcttatcata aatcaacggc
     7861 tggatgatac cgtatgaaag accgttcagg acacacccca aagcaatcaa tatctcagaa
     7921 cggctgagca aaataattcc catcccacaa gctatcatca acaaacaaac catatagatg
     7981 cgacgcccca acacttgcac tatcctgttc agcacaaagc ccggcgccat gatagcaagg
     8041 aaaaacaagg aaatcaatat tcctgccctg ccactggaaa gcccgtactc ttccatcaga
     8101 aaaggaaggt tgaaactgat aatgattacc agataagtag ccagaccgta aaaagccatc
     8161 agcttgatta aggccttgac attcattccc ctcttgccca tttctttggc ggtatcagac
     8221 ggaatatcat cagacggatg ataactggag aggtctttct tcagataatg agtaagaaaa
     8281 atggatataa aaggaaacag ataaaccaaa aacggcaaat gccagttcac ttccgccaga
     8341 tagccagtca atgtagtggc cagtactaag gtgatattgg ttatggcaga actgtaaccg
     8401 aactgtttcg tacggtaagc tcccacaaaa taacgggata tcaatccggt ggaaagcgga
     8461 acaatcaacc cggaccctat ccccaacatg gcgctgatgg ctatcagttg ccacatctta
     8521 ttggagagca gataaaggat accactcacc ccaaagatgg ccaggccgat ttgcagcagc
     8581 aagaggttgt tcactttctc tgtcagctta cccgacaaca agataaaagg aataataaga
     8641 agtgacggca acgaggacag catctggatt tccaaatctg tagcagacgg aaagatttta
     8701 ttcaaatcgc ccaaaatggg agaaaccgcc aatcccggca atgcatttaa tgccgaaatg
     8761 gaaaatatac ctattaaagt aatgagggga atagtcccct gccctgtctg tactttcata
     8821 cttgtagtaa tttattgtat gagatacaca acaaggcaaa agacgtttgg ttcaaagcga
     8881 catatcgttt attcctttac tttccattcc aaaatattat gccaggtagt gtcaaagttt
     8941 acgcctatgt taatttccta aacgcagttt atcaaaattc tgaatgccga tgggataacg
     9001 cttcttcata tttccttctt attgtttaat tacatacccc taaaatatcg gatacgggca
     9061 tccaatgatt ttatgtataa acaaaggtat ctctttttcg ttcatagtac aatgattccc
     9121 atcgtttttt ttgtattccc cctacttaca ttaaaaaaca taaaatcaag gaacttttca
     9181 ccaaccccta tgttgaggga gaaaaacgcg ggaaactccc acgttcttca ttgtattact
     9241 aacctaaact ttaagtaaaa atgaaagatt gtaattgtga tttaagagac ggtgacgcaa
     9301 aaacagccgt gtttggttca aacgaaatgc tgcaacctgc tccggtagac accattccca
     9361 tggaacctac cactccgcag attgcttatc aaatggttaa agacgaaaca ttcgcccaaa
     9421 cccagcctcg tcttaatctg gctactttcg ttaccaccta tatggacgat tatgctacca
     9481 aattgatgaa cgaagctatc aacatcaact atattgatga aacagagtac ccgcgtatcg
     9541 ccgtgatgaa tgccaaatgt atcaacatca tggccaacct atggaattcc cccgaacagg
     9601 caaaatggaa atcaggagcg ttggccatcg gctccagcga ggcttgtatg ctgggtggtg
     9661 tagctgcctg gttgcgctgg agagacagac gtaaagccca gggcaaaccg accgacaaac
     9721 ctaacttcgt catttcaagc ggtttccagg ttgtatggga gaaattcgcc caactttggc
     9781 agattgagat gcgccaagta cctcttactc tggacaagac caccctggac cccgaagaag
     9841 ccttaaagat gtgtgacgag aacaccatct gtattgttcc tatccaaggt gtgacatgga
     9901 caggtctgaa cgatgacgtg gaagcattag acaaagcact ggatgcctac aacgccaaaa
     9961 ccggctatga tattcctatc cacgtagatg ccgcaaccgg tggcttcatc ctgccgttcc
    10021 tcagccccga aacgaaatgg gacttccgtt tgaaatgggt tctttccatc agcacttccg
    10081 gccacaagtt cggactggtt tatccgggac tgggatgggt agtatggaaa gacaagaaat
    10141 accttccgga tgccatgtca ttcagtgtca attatctggg tgcgaacatc acacaggttg
    10201 gtttgaactt cagccgcccc gccgcacaga ttctgggaca atactaccag tttatccgtc
    10261 tgggattcca aggatacaaa gccatccaat acaattccat ggaaatcacc aagtacattc
    10321 acagcgaaat agccaagatg gctccgttcg taaactacag cgacaaagtg gtaaatcctt
    10381 tgttcatctg gtacatgaaa cccgaatacg caaagaacgc caaatggact ctgtacgatt
    10441 tgcaggctaa attacaacaa agcggatgga tggttcctgc ctacaccttg ccggagaaca
    10501 ttcaaaatta tgtggttatg cgtgttgtgg tacgtcaggg attcagccgt gacatggcgg
    10561 atatgttgtt gaacgacatc aagaatgcca tcagcgagtt cgagaaactg gaatatccca
    10621 ctcctacccg catcgcccaa gacaagaata tcgctgtaaa aggtactgtg tttactcaca
    10681 atgcccatag caacgccgct aaaaaataag cataaataac aataatgcaa ccatccgccg
    10741 ttaaggtgga tggttacttc aatcaaatta atttatggaa agaactataa ctatccagca
    10801 aataaaggat gctgcacaag aggcctacaa tctgtataaa gacaatacag acggtaagaa
    10861 cgccgactac attccttatc tggcaaatat tgatcccaaa ctgttcggga tcagtatctg
    10921 tctgatgaac ggagaaatca tccaactggg tgactctcag taccgtttcg gtatcgagtc
    10981 cgtttccaag gtgctgaccg ccatcctggt actccgccaa tacggcgccc ccaaggtgct
    11041 cgaaatgatt ggtgccgacg ctaccggact gccgttcaac tccatcatgg ctatcctgtt
    11101 ggaaaacgac cacccttcca ccccactggt aaacgccggg gccatctcgg cagacagcat
    11161 ggtacaaccc ctaggcaaca gcgacggcaa atggaaagcc atcgtagaca atatgaccga
    11221 actatgcgga agtgccccgc aactgattga cgaattgtac aaatcggagt ctgcaacaaa
    11281 tttcaacaat cgttccatcg cctggttatt gaaaaattat aaccgtatct acgatgatcc
    11341 tgatatgtcg ctcgacctct acacccgtca gtgctctatg ggcatcaccg cggaacaatt
    11401 gtccatctgc ggagccacca tcgccaacga aggattgaac ccgaatacaa acaaacaagt
    11461 gttcgacaag gccctcgccc cgaaaatcac ctccatgata gctaccgtag gtttctacca
    11521 gcacacaggc gactggcttt acacctcagg aatccctgcc aagaccggcg taggaggcgg
    11581 tgtgatgggt gtgatgccgg gtgtaatggg tatttcggcc ttcgcgcctc ctttggacga
    11641 tgccggcaac tccgtaaaag cgcagcttgc catcaaatat attatgaaca aactgggcat
    11701 gaacgtattc aacgggcacc gcatccacgt gcaataatat attctattct gacagaaagc
    11761 cgatatttct ctcaccccga gagaagtacc ggctttttaa ctaaaaaaat tttccgctaa
    11821 atatttctca cactcttaca ttatgcctat ctttgcacag acaaattcat atattatgaa
    11881 gaacaaagtc atccgtaaag aactgggcca atggatgaac tcatgcagag aaaccattta
    11941 tggtccccta gcggagatat tgaaagaaaa ttgctgaaac agcccaaagc gcccgatgac
    12001 gttagttatg tgattgaatt aactattaaa taactttatg agtaacaaat caaaaatcga
    12061 gatttgcgcc aactccgtgg aaagtgctgt gaaggcacaa caagccggtg cttatcgtgt
    12121 agaactatgt gcaggtattc cggaaggcgg aacaaccccg tcttttggcg aaatccgtat
    12181 ggcacgccaa ttattgaacc aaacaaaact acatgtcatt atccgtcccc gtggcggaga
    12241 tttcctatat tctcccatcg agcaagaaat catgttgcat gatattaaag tggcacgtca
    12301 gttgggtgcg gacggtgtgg tgttcggatg tcttaccgca gaaggcaatg tcgatgtacc
    12361 cttgatgcag aaactgatga atgcggtagg cgagatgagt gtcaccttcc accgcgcttt
    12421 tgatatgtgc agcaatccca aagaagcctt ggaacagatt atcggcctgg gtatcgaccg
    12481 ggtccttact tccggacaag aagcgactgc cgaaaagggt atccctcttt taaaagaatt
    12541 ggtagaactg gccgacggac gaatcatcat catgccggga tgcggtgtga atgccggtaa
    12601 tatccgtaag attgccgaag aaaccggaac ttcggaattt catttctccg gacggagcag
    12661 cgtagacagc ggcatgattt atcgtaactc aaaagtatct atgggaggta ctgtaaagat
    12721 agaagagtat ctgaaggatg ttactgaccc caacaaagta aaagccgcct tgtccgaact
    12781 ggcactgaaa gacgaaaacg acaaagcact ggaaaagaaa aacaaaagcc tcaaccccaa
    12841 gaaatcaaag aaagaggatg actgggacga tgacgatgat gatttggatg atgacaagta
    12901 ataagcaagc ataaacgtta ttatcatatt aaacgcggat attcagggtt tcaagctgaa
    12961 tatccgcgtt actttttgtt tatactgaat tctacaactt atgtatcacc ttcatcagct
    13021 gctcacccag cccgatggta tatccttgtg acacgaatac cacccggtta aaggtatcac
    13081 caatgataaa cataggcaag atagtcttgt tagacaactt catgccttct gcaatctgct
    13141 tctggatgga accgtccaca tcaataccgt aagtaatggt agccggtaat cctgggaatt
    13201 cctgcggacg gaacttcttg tactgctcct cattggggaa caacagcacg attcctctgc
    13261 cccattcatc aaagtccttg cccaatgccg cgatatcgcg caatgcatgg ttggtaggtt
    13321 cttgtccggc gcccagtacg gctacaatgt agtaaccacg tcctgtagtg gcaagaatgg
    13381 acttcagttc atcgctatcc atcggtttat aagtagattc tgaattgaaa ttaccgatca
    13441 cctgaatatc atccttactt tcacgcatca ccaagtccac cgtagtcgtt tctcccggct
    13501 tgatggtaaa gaaagtcagc tgggacaata cgccgccgtt agccagacga gtaccggtca
    13561 ccatcacata attgccggca tccagtgccg ttccgttctt caacagatta gcccaagtag
    13621 cgccgccacc catatcaata tcgccttcat cataattcag caatttcaaa gttccggcag
    13681 gagtcagtct ggaaatagag aaatgagaat aatacttcgg atcagccaaa gacttgatcg
    13741 gcgtatatct ggcaataaac ttgccggtaa gtgcactggc ctgttccatt gcttcgaaat
    13801 tcacatcaat agcaccttca tcgcctatca actgcacttt tcccgtcact tcgtctatac
    13861 gtgcaggaat acccatgctg cgtgccatgg atacaaagaa gatatcacgg ctgtgcgcat
    13921 cggctgtacg ggccttccac accccttccg gagtgattgg cgagccgccc aggttgcaat
    13981 ccttgtccac acggatattc ccggcaaccc atgcaaccag cttcatcgga tcggcaaggt
    14041 aagcctcacg atcctgttcg ggcactgctt tctcaaagaa ccctttatac ggagtaatca
    14101 tttcgttgct cacgcgcgga ttacgcacaa atctgcggaa ataatcagca ttggcgcaca
    14161 agtgtgaatt catcatgtgg tctatcaaca cttcggagct tacatcacga aggtctttgg
    14221 cagaaatctg ctgaagcagg tcaatgccgc ccttctttga cttgtccgaa cggagacggg
    14281 ccataaagtc acggatggtt tcgtagttgc cacgtgatgc caccagcaat ttggcaacgg
    14341 catcctcatc cagctggtat tctttagcga aattgcgagc cgattcatcc gtcatgaatg
    14401 tagccacgta ggcattgcgg atagagtcct ccaaagccat gcggcgattg ttctccgcac
    14461 gttgttcggg agtcacttcg ggcatattgg cgccttccat cggaggaatg atatccatat
    14521 ccagtgtata agcctcgccg gccgttttgt ccaatttcac ggtcaaggca ttgtcctgtc
    14581 cgaaagacag tttggaataa ccgaattttc catctttgga agcccatacc agcatatccc
    14641 cttttccggc ggtcaggaac gtcttaccgt cc
//
