LOCUS       gnlProkkaIDPJLOPE_52   12935 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IDPJLOPE_52.
ACCESSION   gnlProkkaIDPJLOPE_52
VERSION     gnlProkkaIDPJLOPE_52
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 16:24:51
            Original ID  :: gnl|Prokka|IDPJLOPE_52
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12935
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12935
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3621:7935]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3622..7935
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12935
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12935
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..2399
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.4;
                     E-value: 6.7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg52_1"
                     /sec_met_domain="Poly_export (E-value: 4e-17, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSILLFCSMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQKQLAS
                     ELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLEDHPTTQ
                     DLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIRQQISP
                     EGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNIRTIQI
                     NVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVYEFIMK
                     GNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGFEADAY
                     TRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAVYRPGI
                     YQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGTSPNLA
                     LMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEAASTVR
                     IDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPGYQAQQ
                     NVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKKRMGDV
                     IRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIPKNTNT
                     VTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKGSGKKQ
                     IEPGCEIIVPSKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             2410..3558
                     /locus_tag="ctg52_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             3622..4341
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 6.1e-15, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             4362..5663
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208;
                     E-value: 2.8e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_4"
                     /sec_met_domain="CTP_transf_like (E-value: 7.4e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.5e-119, bitscore:
                     393.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.4e-61, bitscore:
                     203.0, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVRAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5680..6804
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4e-19, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.5e-19, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             6814..7935
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 3.2e-34.
                     Score: 110.2. Matches aSDomain:
                     nrpspksdomains_ctg52_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.8; E-value:
                     2.7e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_6"
                     /sec_met_domain="Aminotran_5 (E-value: 8.5e-30, bitscore:
                     98.8, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKVSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        6904..7911
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg52_6_Aminotran_5.1"
                     /evalue="3.20E-34"
                     /label="ctg52_6_Aminotran_5.1"
                     /locus_tag="ctg52_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.2"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKVSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             7932..8075
                     /locus_tag="ctg52_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             8278..9762
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_8"
                     /sec_met_domain="Polysacc_synt (E-value: 5.1e-30, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9716..10741
                     /locus_tag="ctg52_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVINPISQ
                     K"
     CDS             11483..11776
                     /locus_tag="ctg52_10"
                     /transl_table=11
                     /translation="MANYATNIFHASTENKQDLDKIEAFLDDNFNGFVNRYGDTVDAEF
                     SSRWEYPEKEIDELVASLEAKDKIYIRILTYELEDEYVSFRIFSQGKWDIKL"
     CDS             11795..11971
                     /locus_tag="ctg52_11"
                     /transl_table=11
                     /translation="MYEYEEDSDIIGLSCTLLNPYKGYTEGTIVGNYGNTIVVRLESGK
                     EISEYRDEVIIHD"
     CDS             11986..12318
                     /locus_tag="ctg52_12"
                     /transl_table=11
                     /translation="MTQIATKFVKWDIPELATLQDSKVYKLRVHLNNGGKLNREEKNWI
                     TRNVWESIYFKRGIALSGYHFDFSDVLKRYFVKQHGSIHEYYAIDKTALRSILYGRIED
                     IVEVNS"
     CDS             12330..12626
                     /locus_tag="ctg52_13"
                     /transl_table=11
                     /translation="MGEYKFYQDRKVTSWERDYFSVKANSYEEAEAIVRSWNCEDVSNI
                     IDNRLCYEEWQALTDTSESMLPEENDGNPTIEIFNEDGESIMTNVPKTPQSNQ"
     CDS             12631..12888
                     /locus_tag="ctg52_14"
                     /transl_table=11
                     /translation="MNVTIEHVFCRYSDEAEEIYFRIMNTILFATDETELRASMERLKN
                     ETSLDEYFIFGYGAHHIWINQRRPSDKNRIFKNRIMVAHF"
ORIGIN
        1 gactttttag cattctactt ttttgttcta tgctgggaag tggctcgctt atggctcagt
       61 ccatgagtga ctcacaggta ctggaatatg taaaagacgg catccgccaa ggcaaggaac
      121 agaagcagct tgcttccgaa ctagcccgta agggtgtaac caaagaacag gcaatgcgtg
      181 tgaagcagct atacgagcag cagaacaatg taaatacctc gaaatcaacg ggcacggaca
      241 tcaacgaatc ccgcctgcgt gaagagacta agaagaatac ttccgatatg ctggaggatc
      301 atccgactac tcaggacctt gcccgtggtg atcaggtctt cggacgtaac atcttcaata
      361 cccgcaacct gacgttcgag cctagtgtca accttgccac tcctgccaat taccgtcttg
      421 gtcccggtga tgaagtcatc attgatatct ggggtgcgag ccagaacacg atccgccagc
      481 aaatctctcc tgaaggtact atcaacattc agaagatcgg ccctgtcaac cttagcggta
      541 tgacagtctc tgccgccaat gactatctga agaacgccct gaataaaata tataacggtc
      601 tgaataatac taccgatcct acttccgaca tccgtctgac gttaggtaat atccgtacta
      661 ttcagattaa tgtgatggga gaagtcgtac agcccggtac ctacgccctt tcttccttct
      721 ctaccgtctt ccatgcgctt tatcgtgcag gcggtgtgag tgatatcggt agcctccgaa
      781 acgttcagtt ggtacgcaac ggaaagaata ttgccaccat cgacgtctac gaattcatta
      841 tgaaaggcaa cacacaggat gacatccgcc tacaggaagg tgacgttgtg attgttcctg
      901 cctatgatgt attggtaaag attagcggca aggtaaaacg tcctatgcgt tttgaaatga
      961 agaaagacga gaaccttgct actctcatta aatatgccgg cggctttgaa gctgatgcct
     1021 acacccgttc attacgtgtt gtccgtcaga atggtgagga atacgaagtc aacacagtca
     1081 aagatataga ttacaacatt tataaaatgc gtaacggtga cgtagtaacc gccgaagcca
     1141 tccttaaccg cttcacaaac aaactggaaa tccgtggcgc tgtctatcgt cccggtatct
     1201 accagctcag cggtaaactg aacacgatcc gcgaacttgt ccatgaagct cagggtctga
     1261 ccggtgacgc tttcctgaat cgtgccgtcc tctatcgcca gcgtgaagac ctgaccagtg
     1321 aagttgttca gatagacatt aagtctatca tggacggcac ttccccaaac cttgccctaa
     1381 tgaagaatga catcctctac attccaagta tccatgacct ggaagaccgg ggtaatgtca
     1441 cagttcacgg tgaggttgcc caccctgatt cctatcctta tgcggataac atgacacttg
     1501 aggatctgat cattcaggcc ggtggcttga aagaagccgc ctctactgtc cgtattgata
     1561 tatcgagacg aatcaagaat cctcgtagta ctgcggataa tgatacgatt ggtcagatgt
     1621 ataccttctc tttaaaggat ggttttgtaa tagatggtca gcccggtttt atccttgagc
     1681 cttatgatca ggtttatgtc cgtcgcagtc cgggctatca ggcacaacag aatgtagcca
     1741 ttgaaggtga aatccttttc ggaggaaatt acgccatgac cagccgtgag gaacgtcttt
     1801 ccgatttagt gaataaagcc ggcggtccga ccaattatgc ctatctgcgt ggtgcgaaac
     1861 tgacccgtgt ggctaacgct agtgaaaaga aacgtatggg tgatgtaatt cgccttatga
     1921 gcaggcaatt gggcgaagcc atgattgact ctttgggtat tcgtgttgaa gatactttta
     1981 cggttggaat agatttggaa aaagccttga gcaatcctaa aagtaatgcc gatcttgtct
     2041 tacgtgaagg tgatgtgatc tccataccta agaatactaa tactgtaact atcaatggtg
     2101 ctgtcatggt tccgaatacg gtttcttata tgaagggaaa gaatgtggat tattacctga
     2161 atcaggccgg tggctgttct gataatgcaa ggaagagtaa gaagttcatt gtttacatga
     2221 atggtcaggt gacgaaggtt aagggtagtg gtaagaaaca gattgagccg ggatgtgaga
     2281 ttattgtgcc tagtaaggct aagaagaaag ggaacatagc taatatttta ggttatgcta
     2341 cttccttcag ttctttggga atgatgattg cttctattgc taatttgata aagaaataaa
     2401 tgacctatta tgattgaaaa gcaatcttat caagaaccgt tttctgaagt ggataaaagg
     2461 aaagatgatg aaatggaaat agacttgatg gctatttttt ataagattat tactgttcgt
     2521 ggagtactat gcaaagctgc tggagtggga gtaataattg ctatagtggt ggcattgagc
     2581 attcccaagc aatatacagt aaaggttacc ctttctcctg aaatgggtaa tgcgaaggga
     2641 agtaatggtt tagccggact tgctgcctcg tttttgggag atggggctct aataggggaa
     2701 agcacagatg ccttgaacgc ttctctttca gcagatattg tttcttcaac tcctttttta
     2761 ttggaacttt tagaaatgga agtctccgtt tctaaaaagg atgataaaat gactttgggg
     2821 tcttatctcg atgaagagtc atctccttgg tgggattatc ttataggttt tccgggcata
     2881 gtaataggag gagttaaatc attattcgga gaagatacgg ttcctgccag tggagggcgg
     2941 caaggaacta tcgaattgac gaaagaagta aatgagaaga ttaattttct taaaaagaag
     3001 attagtgcat ccattgataa gaaaaccgcc ataacgagca ttacggtcac cttacaaaat
     3061 ccgcagatca ctgcggttat agcagattct gtcgttcata aattacagga atatattatt
     3121 gggtatcgaa cttcaaaagt aaaagaagac tgtgcgtatt tggaacggtt gtttaaagaa
     3181 cgtcagcagg aatattatgc tgctcaaaga aaatatgcgg attatgtaga cgcccatgat
     3241 aatgtggttc ttcaaagtgt acgtgctgag caggagcgtt tacagaacga catgagtttg
     3301 gcttatcaga tatatagtca ggttgctaat cagttgcagg tatccagagc caaagtacag
     3361 gaggaaaagc cagtctttgc agtagttgag cctgccgttg tacctttgaa accttcaggt
     3421 atgggactca aaatttatat tttattattt gtgttcctgt ccgtatctgg tactctcgtg
     3481 tgggtgcttt ttggcaaaag tctgctggct agcttgagaa aagaactgaa aaataaggag
     3541 atagaacagg ataaatgatg ctaaaacgtc gtttacaaca ttcttacatc aattaaattc
     3601 acttactata ttattaaacg aatgatacgt acagctatga taatggctgc gggcatggga
     3661 acccgttttg gccaatatac agaattgata cctaaagggt tcgtcaaagt gggaggtatt
     3721 ccaatgatag ttcgttctat tgatactttg ttatcatgtg acattgagcg aattgtaatc
     3781 ggtacaggat ataaacaaga agtttatgaa gaattgaaga cagactatcc tatgcttgaa
     3841 acctgtttta gtcctcgtta tgctgaaaca aatagtatgt atactttata taatacgcgg
     3901 gagattctgg gcaatgatga ttttttattg ttagagtcag atttgatttt tgagaaacaa
     3961 gcaataatga gcttattgga gtgtcctgcg gcagatgcaa tgctaataac tccagtgaca
     4021 aagtttcaag atcagtatta tgtggaacat gatgataatt ttcgcctttc ttcatgttct
     4081 gtcaataaga ataaactaaa cgctaaaggc gaattggtcg gcatccataa actatccggt
     4141 tccttttaca aaataatgtg tgctgattat gcgagtattg ttgatgaaca acccaatttg
     4201 ggatatgagt atgaattact acgaatatct tgttctcaat ctcctgttta tgtgcataaa
     4261 gtagaagggc tgaaatggta tgaaatcgat gacatatcag atttggaata tgcagagaaa
     4321 tatattgttc cgtattgtta attaaaataa tatatcaaat tatgagtaag acagtttata
     4381 ttgggatgac tgcggatatt atgcatccag gacttatccg cattattaat gaggctacta
     4441 aatacggtga tgttataatt ggtcttctta cagataaagc tattgcggag cataaacgcc
     4501 ttccttatct gacctatgaa caacgaaaag aggtagttca gaatattaaa ggcgtatgta
     4561 aagttgttcc tcaagaagaa tggagctatg ttgagaatct caaacgcatt aaacctgact
     4621 atataattca tggtgacgac tggaaaaccg ggcctttacg tgaagaacgt gtgcgcgtat
     4681 ttgaagtgat gaatgaacag ggaggaaagg ttatcgaaat tccatatact ttgggaatta
     4741 attcatcttc tttggataaa gatattaagg ctataggtac aacccctgat gtacgtttaa
     4801 aatcacttcg tcgtttgata aatgccaaac ccgtagttcg tattttggaa gctcatgatg
     4861 gactatgtgg cttgataatt gaaaatcagg aaatattaaa aggggataag agggaagtat
     4921 ttgacggaat gtggtctagt agccttacgg attcaaccag taaaggtaaa cctgatattg
     4981 aggcggttga tttaactacc cgattgcaag atttgaataa tattctggag tgtactacta
     5041 aacctattat ttttgatgga gatacaggtg gtaaaattga acatttcgta tttacagtac
     5101 gcactttaga acgtcatgga atttcagcta taataattga agataaagtt ggattaaaaa
     5161 agaattcatt gtttggtaca gatgttattc aaactcaaga tacaatcgaa ggtttctgta
     5221 ataagatcaa agcaggaaag gcatctcaga ttactgatga ttttatgatt atcgctcgta
     5281 ttgagagcct tatagcggga aagccggtaa gtgatgcttt agagagagct tttgcatatg
     5341 tccgagcggg agcggacggt attatgatac atagcaaaaa taagtcgggt gaagatataa
     5401 aagaattttg tttggcgttt cgaaaacagt atgctcatgt acctatcgtg gttgtgccta
     5461 ctacatatga tcatatttat gagtctgaat tgtgtgattg gggtgtgaat ataattattt
     5521 atgctaatca tatgcttcgt gccgcttatc ctgctatgat gaatgtcgca aagataatat
     5581 tagagaatga acgtgcttta gaggtgcgcg aactgtgtat gcccataaaa gaaatattgg
     5641 aactgattcc aggtactaaa taaaaagagg aatatcatta tgttaagcgt agaaaaagtt
     5701 tatgaaacgt ttctgagtca tgacgttgat ttttttacag gagttccaga ctcattacta
     5761 aaaaatattt gtgcctatat cacagaccat acttcacgtg agaaacatat catagctgct
     5821 aatgaaggtg cggctgtagg aattgcttca ggttattata tggcatcagg taaggttcct
     5881 gtggtttata tgcaaaattc cggcttgggt aatactgtta atcctctgct gtctcttgca
     5941 gatgaacaag tatacagttt tccaatgctt ttgatgattg gctggcgtgg tgaaccggga
     6001 acaaaagatg aacctcagca taaaaaacag ggtgaggtaa ctttagattt gttgaaagca
     6061 atgcggattc cttatataat tcttgattca aatgagaatg atgcatttat tcagctccat
     6121 gatatcatac aatcagcaaa aactaagaat attcctcatg caataattat tcggaaagat
     6181 gtttttggca aatataaact tcaaaaagag ttcggatgta attatccttt atctcgtgag
     6241 gatgctttgc aaatagttgt ggattatctg cctgaaaatt cagtggtcgt ttctactact
     6301 ggcaagcttt ctcgtgagtt atttgaatat cgagaaatga aagagcaagg tcatgaacat
     6361 gattttctca cggtaggctc tatgggacat agttcatcaa tctctttggg tattgctata
     6421 gcaaagcaag atagacctgt ttattgcttg gatggtgatg gagcatttat tatgcattta
     6481 ggggcaatta gtaacattgg cgatttatct cctaaaaact attatcatat tttgtttaac
     6541 aatggtgctc acgagtctgt aggaggacag cctactttag gatttagttt agatattccg
     6601 gctattgtcc gggggagcgg atataagcat acttatactg tttgtacaaa agttgaaatt
     6661 gaagaagcaa tgaagcagct tccaaagtta tgtggtcctg ttttgttgga aataaaggtt
     6721 aaaatagatt ctcgggagaa tttgggacgt cccacgacta ctcctataga gaataaggag
     6781 cattttatgg attttttaaa ataaatatat tcgatgaaaa tagaaagaaa aatattatta
     6841 aatcctgggc ctgccactac tactgacagt gtaaaaatgg cacaagttgt tccggatatt
     6901 tgtcctcgcg agaaagaatt cgcaggtatg atgaaacaac ttcgggacga tttggtcaga
     6961 gttgctcatg ggaatttgga aaaacatacc gctgtattat tttgtggctc aggaaccatc
     7021 aatattgata tatgtctaaa ttctcttctt cctgaagaca aaagggtgct tatagtgaat
     7081 aatggggcat atagtacccg tgctgtagaa gtgtgtcaat attatggttt gcctcatatt
     7141 aatttggaat tttccgttta cgaacgtcct gatttatcgg tggtggaaaa tgtgttgcaa
     7201 gaaaatcctg atatagctat ggtttatact actcatcacg agacgggtac aggaattctg
     7261 aaccctattc gcgagatggg cgctatagct cataaatatc aggctaaatt tgtcgtcgat
     7321 actacttctt ctttgggcat gattcctttt gatatagaga aagataatgt agatttttgt
     7381 atggcatctg ctcaaaaagg acttcaagcg atgacaggtc tttcttttat tataggcaat
     7441 gaggaacaga ttaaggtttc aaaaaaatat cccaagcgtt cttactattg taatctttat
     7501 ttgcagtatg agaattttga gagaacaggt gaaatgcatt ttactccacc ggtacaaact
     7561 atttacgcca ctcgtcaggc attaaatgaa tattttgaag tgggtgaaga agctaagttt
     7621 gcccgtcaca aaagagtttt tgaggctatt cattcaggta taaatgaaat tggtcttaaa
     7681 agtgtaataa agcgtgaatg gcagtcagga ctggttgtct cagttcaata cccagaagat
     7741 cccaactggg attttgagaa aatacatgat tattgttatg agcgtggatt tacgatttat
     7801 ccaggtaaga tatcaactga ggatactttt agaatctgtg ctttaggaga gatagaagta
     7861 gatgatattg agaacttctt taaagtacta aaagctgcat taaatcatta taacgtcaca
     7921 ttaccgatgt catgattgca gaaatattat tgaagattcg tcatttttat ttttcccttc
     7981 gtggtataca cttccatccg gaaagtgtta tttctggagt gcctattcgt agctttcgct
     8041 tagtaggcaa atatggcaat attaatttga ggtgatgcat taggagttct ttattcttat
     8101 aaaaaggcat cggtagttat aggagataat gtttgtgtag ggtaatttgc ttttagtggg
     8161 agagaccata ttagaattgc ggtaaggggc gaagaagata ataaccaatt agtgagaata
     8221 ttggaaaaat ataattgata tcggtaaatg tagttgtttt tatactgtat ttaagtaatg
     8281 gaaaatctaa agcagaaaac tgtatcagga ataatgtgga gcgctataga acgtttctct
     8341 ttacaaggag tacagtttat aattcaaata atattagctc gtttgttact accatcggat
     8401 tatggtatga tcgggatgtt agctattttt cttcaagtcg ctcaagtatt tatagatagc
     8461 ggttttacaa atgctttaat ccagaaaaaa gatagaactg aagaggattt tgccactgtc
     8521 ttttatttta atattcttgt cgcagtatta ttctatggta tattgttttt ttcggcttct
     8581 ttgattgcag acttttataa tatgccgact ttagttcttg taattcgttt tatagcattg
     8641 tcgttgataa taaatgcttt atcggctatt cacagaacga aattaattat ttctgtaaac
     8701 tttaaaactc aatctaaaat ttcattaggt gcagctttta tatcaggcgt gattggaata
     8761 tggatggctt atgtcggttg cggggtttgg gctttagttt ggcaaactct cttaaatagt
     8821 ataattttga caattttgtt ttactgttta gttcattgga aacctttaca tactttctcc
     8881 aaaagttctt ttgaaagatt attcaatttc ggatctaaat tattgatctc aagtcttatc
     8941 aatacagtat atcgtaatct gtataccatt gtaataggaa aaaagttttc tgttgtagag
     9001 cttggttact atacaagagc agaacaattt gctatttttc cttccaataa tttaaatgct
     9061 ttagtttcta gagtagcgta tcctatttta agttccattc aagatgatga taaatgttta
     9121 acaaacgcat atcgaaatta tatcagatta tcctcatata taatttttcc tttaatggta
     9181 ggtttacttg ttttggctaa tcctattatt agtctattgt taacagataa atggtctggg
     9241 gttgttattc ttttacagat attatgtttg gattggatgt ttgatcattt gagccaaatt
     9301 aatttgaatt tattatgggt taaaggaaga tctgatctgt cgttacgtct tgaaataata
     9361 aaaaagacga ttgctatatt cattcttttt gtgtcaattc catttgggct tgaggtgatg
     9421 tgttggggta gagttattta ctctctgata gcgacatatt tgaatacata ttatactaat
     9481 tctcttattg atttgacctt aaagttgcaa gttaaagatg tatttccaag tttaatactc
     9541 tctttcataa tgggggggat cgtttttata tgtatttctt tctttgaaac tgatatagta
     9601 aaaattgtga ttggatgtat tactgggatg tccttctata ttttactttc ttttcttttt
     9661 aagctagatt cttttttttg tattttaaca ttgatcatta aaactaaaaa catagatgaa
     9721 aatattaaaa aagatttttc aagtaatagt aaagataatt aaccattgtg tgccagttga
     9781 tagtagatca ttgtatttta ttcctcatcc taattgtaga acagataaat atgatattat
     9841 aaattattcg tcagataatg ttctcgttct gttaaattat ttgctaaaaa aagatagtgc
     9901 tgaatattat aaaatatatg ttgaaattta tgattcttct cgtatttcag aatatcaaga
     9961 atatatttat ggcataaatc ctaatattag gtgtactttt ttatgtgcat gtgttggacg
    10021 ttttttcttt aataaagtat cttttaagga tatgttgtat gccttttttt gtttttgtag
    10081 agcaagtaaa tgttttacag ctacttttta ttatgatttt tcatttaaaa aacgctctca
    10141 acagattatt tgtttggggt attatactcc attcaaagat gattatcata tgggagatca
    10201 ttcttatgat aaatttcgta atacaacatg taactcattt gattactcta ttgctacttc
    10261 ttgtttaagt gctagaataa tttcaataga ttgtggaatc tcatatgata aattcaaagt
    10321 cttaggattt cccagaaatg atttgttgat atcgaaaaat aattgcaatg ttattaaaag
    10381 agaaatttcg aaatttgcgg gatatgatgt aactaaatat atagtttata ctccaacttt
    10441 tcgtgattat gagactgtta ctgaaggtaa tttgcgttca atactcggat atgttgattg
    10501 tgatttgttg aagttatcga aaatactatt gaagtttaat gcggctttaa ttcttaaatt
    10561 acatcctttg cagaataaaa cagtcttaaa aaaagattta cccaaaggta tacttgtttt
    10621 tgaacaaaca tataaatatg gattgtatga tcttttgtca ttttcagatg gaatgattac
    10681 tgattatact tctacctatt ttgatttttt attggtaata aatccaatct ctcaaaaata
    10741 gtatatataa tgatttgaaa ttcagtgtgt tgaaaatttt atagttttaa ttgaggaaca
    10801 aataagaaac aaaattgcta attaaaggca tttcccgatt ttttgttttc actctgtttc
    10861 tttccttgca cttacttata atcgggactt cttgaaccag cttcctacca gaattttttt
    10921 cctcgtccga cggttgtatt tgaacttcca agaaccattg cagccaaaag aaaagcaagc
    10981 cttctttaat tcatacaaag ataaggaaaa acttataggc aggcaaattt gtctgcctaa
    11041 atatagttta ctttgattta gcatatatat aggctaatgg actaaactaa accttttccc
    11101 gaacttcgta aaacactctg gtcccattgt gcagccaaaa gaaaaaaaga ttccacggca
    11161 tatttttctt ttcgctgcaa ctcccttttt ataaaccatc aaccttttac acgagatctt
    11221 ctcttccctg tattcgcaca tccgctttcg ggctgtctga tatgaattgt gtcgcaaagg
    11281 tacttgacat gtctttcttg tatgcaaggt cacagcctga cggttcacga caaaatctcc
    11341 acgctccgct ttgcggaggt agtatttggt tgtgaaaccc tgcataaaga gccatgtcac
    11401 cttttgaagc gacataatta aatcaagccc gaaagtagct gatgctacaa gagggaaaaa
    11461 agaaaactca aaatttaaga ttatggcgaa ctatgcaaca aacatttttc acgcaagtac
    11521 ggaaaacaag caagacctcg ataaaataga ggcatttctg gacgataatt tcaacggttt
    11581 tgtcaatcgg tatggcgaca ctgtagatgc agaattttct tcccgttggg aatacccaga
    11641 aaaagaaatc gacgaactgg tagcttcttt ggaagccaaa gataaaatct atatccgcat
    11701 actgacatac gagttagagg acgaatacgt gagctttcgg atattctcgc aaggcaagtg
    11761 ggacattaag ctgtaaccta aaaacgcatt cactatgtac gaatacgaag aagacagcga
    11821 tattatcggt ttgtcttgca cactgctcaa tccatacaaa ggttacacgg aaggtacaat
    11881 cgtgggcaac tatggtaaca ccatagttgt ccgccttgaa agcggcaagg aaatttcaga
    11941 ataccgtgat gaagtgatta tccatgatta aacgatagca aacgtatgac acagatagca
    12001 acaaaattcg tcaaatggga tattcccgaa ctggcgacat tacaggacag caaggtttac
    12061 aaattgcggg tacacctgaa caacggaggc aagttaaacc gggaagaaaa gaactggatt
    12121 acccgtaacg tgtgggaaag catctatttc aaacgtggaa ttgccttgag cggttatcat
    12181 tttgattttt ccgacgttct caaacggtat ttcgtcaaac agcacggaag cattcacgag
    12241 tattatgcga ttgacaaaac agcgttacgc tcgatactgt acggcagaat cgaggatatt
    12301 gtagaagtaa acagttaaac aacaaggata tgggagaata caaattttat caagaccgta
    12361 aggttacaag ttgggaacgg gattatttca gtgtaaaagc aaatagttac gaagaagccg
    12421 aggcaatcgt ccgctcatgg aactgtgagg acgtgtcgaa catcattgac aaccgtcttt
    12481 gctatgaaga gtggcaagca ttgaccgata catcggaatc tatgctcccc gaagaaaacg
    12541 acggcaaccc gacaatagag attttcaacg aagacggaga atcaataatg accaatgtac
    12601 ctaaaacacc tcaatcaaac caatagaacc atgaacgtaa caatcgaaca cgtcttttgc
    12661 cgctatagcg atgaagcgga agaaatctat ttccgaatca tgaacacgat tctttttgca
    12721 actgacgaaa ccgaacttcg tgcaagtatg gaacgtttga agaacgagac ctcactcgat
    12781 gagtatttta tattcggata cggagcacac catatctgga taaaccaacg gcgaccgagt
    12841 gataaaaaca gaattttcaa aaatcggatt atggtagccc atttctgacg ggaacgggca
    12901 agagacctcc gatgtacttt tgcgggctaa accgg
//
