LOCUS       c00037_gnlPro..        16863 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IDPJLOPE_37.
ACCESSION   c00037_gnlPro..
VERSION     c00037_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 16:02:29
            Original ID  :: gnl|Prokka|IDPJLOPE_37
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 77785
            Orig. end    :: 94648
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16863
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[87785:90756]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..12971
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16863
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16863
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             1054..1362
                     /locus_tag="ctg37_58"
                     /transl_table=11
                     /translation="MTNLQELLLKPVWQMTGEEFIFLSKHASGQTETQPRPVTDTERKY
                     VYGILGIAKLFGCSLPTANRIKKSGKIDKAITQIGRKIIVDVELALELAGKKTGGRK"
     CDS             1386..2453
                     /locus_tag="ctg37_59"
                     /transl_table=11
                     /translation="MKEFKDISAEEAVILWQASRLSLSKSYEKAPEILKVHGSVIGTLG
                     NFSASIGKAKSKKTFNVSTIVAAALKNGTVLRYVAELSYGKRKVLYVDTEQSPYHCLKV
                     MKRILRMADLPDDRDNENLEFLALRKYTPEQRIRIVEQAIYNTPDIGLVIIDGIRDMVY
                     DINSPGESTRIISKLMQWTDDRQIHIHTILHQNKGDENARGHIGTELNNKAETVLLVEK
                     DKSNGDISNVSAMHIRAMDFEPFAFRINDSALPELIEGYKPEAKKPGRPEEEKFDPYRH
                     ITEQQHRIALEAVFGLKEEYGYKELEDALIKSYTSIGVKLNHQKAVPLITMLRNKRMIV
                     QENGRKYTFMPDFHY"
     CDS             2666..3622
                     /locus_tag="ctg37_60"
                     /transl_table=11
                     /translation="MDIQTTKQIRIADYLHSLGYSPVKQQGINLWYKSPLREETEASFK
                     VNTERNQWYDFALGKGGNIIALAQELYCSNHVPYLLQRIEEQTPHIRPDSFSFGKQSSS
                     EPRFQQLEIVPLSSPALLSYLQGRGINLELAKRECREARCTHNGKRYFAIAFPNGSGGF
                     EVRNPYFKGCIAPKEISHIRQAGKARTTCYVFEGFMDYLSFLTLRQESCPNYPELDGQD
                     YIVLNSVSNVSKALYPLGSYERIHCFFDNDRAGMEALRQIRMEYGRDLYIRDASQTYSG
                     CKDLNEYLQKQAERNRQIQSVRKTHTQPPKKKNGFRL"
     CDS             3914..5236
                     /locus_tag="ctg37_61"
                     /transl_table=11
                     /translation="MRNIGESRIYVVPELSTDNEQWINPDFGTPELRTHYDNIKQMVKN
                     KTGRAMQEKERERKGKNGRIIKVAGCSPIREGVLLIRPDTTLADVRKFGEECQRRWGIT
                     PLQIFLHKDEGHWLNGQPEAEDKESFQIGSRWFKPNYHAHIVFDWMNHETGKSRKLNDE
                     DMAIMQTLASDILLMERGQAKAVTGKEHLERNDFIIEKQKAELQRIEETKRHKEQQVSL
                     AEQELKQVKAEIRTDKLKSAATDVATAITSSVGSLFGSGKLKELEHHIEQLHQEITKRD
                     KATDELKIQIQQIHEQHGRQIRNLQGIHNQELEAKEKEISRLNTILEKALCWFPLLKEM
                     LRMEKLCYVTGFTKGMVDSLLYKKEALRCSGKIYSEEYRQRFETKNVIFKIERSPIDKN
                     KLMLTINQQPISEWFKEQWEKLQQHLRNSVQKEQKSRGFRM"
     CDS             complement(5383..6258)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_62"
                     /sec_met_domain="Radical_SAM (E-value: 9.1e-17, bitscore:
                     54.1, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTEIIKEIDVQSVMTKSSLPVGGYSVNPYVGCPHACKYCYASFM
                     KRFTGHTEPWGAFLDVKNWKPIANPHKYDGERIVIGSVTDGYNPYEEQFCRTHRLLEEL
                     RGSNAEIMICTKSDLVLRDLDLLKRFPKVTVSWSINTLDERFRTDMDNAVSIERRLNAM
                     RQVYEAGIRTVCFVSPIFPGITDMKAIIEKVKGYADLIWLENLNLRGQFKGGIMTYIRE
                     KHPDLFPLYEEIYNKKRLDYWQALEQDISQYAKAQGFPYRINDLPYGRSEKGKPVIVNY
                     FYHEKIRLTK"
     CDS             complement(6255..6950)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_63"
                     /sec_met_domain="Radical_SAM (E-value: 9.2e-08, bitscore:
                     24.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILKRNSKQMTICIKSLIKNMNIVVGCSIGCSYCYARNNCRRFHI
                     TDDFSVPEYMVRKLRIIDTPKPHVWLMTGMSDFSDWKPEWNAEIFRRMKSNPQHAYIFL
                     TKCPDKISFSTDDENVWMGVTVTRNSEKKRLDDLKRNIKAKHYHVTFEPIFDEIGDIDF
                     EGIDWIVIGTETGHRKGKVDSRPEWVLHIADQAQTQGVPVFMKEDLLPIMGEERMIQEL
                     PEQFTKRLQ"
     CDS             complement(6947..7411)
                     /locus_tag="ctg37_64"
                     /transl_table=11
                     /translation="MKKIRKIAVEQNFAAISVGKLNELNEYELQLGPDVKIPGKVFCST
                     ALGTTGSEFSFQSFAPGTETGFLHSHKSHEELYFFLSGKGEFQVDGTVFPVEEGSVVRV
                     SPAGKRSVRNNGTTPLLMLCIQYCSNTFSQEDATDGIILKEPVKWKVSPK"
     CDS             complement(7445..8224)
                     /locus_tag="ctg37_65"
                     /transl_table=11
                     /translation="MNEKAIIRLVRSATLKINYAGHTILIDPVFADKGTLQSALGVYKN
                     PRVHLVMPISDITEGVDMVLLTHNHIDHYEPSVKQHLPKDIPFYTQPQDKAAILKDGFS
                     NVETIEESITLGHLTIHRAIGHHGFGQIGQMMGPVSGYVLMSEGLPTIYIMGDCKWEEC
                     TLATVEKYRPNYIVVNSGGAVFPEFSKTDGCIIPNEQEVMAMLDTLPPHIKLITVHMDA
                     IDHCQTTRAILRNEARHHGTDMSRLIIPEDGESITLK"
     CDS             8277..9260
                     /locus_tag="ctg37_66"
                     /transl_table=11
                     /translation="MSLCLKNRNICHFDKRMMYICRKQKTRVMKAIINPERLVSVPFNK
                     TQCGVDFYINTGESKDICGVLTEHKTFKTDFFSFYFFRRANGYLLLSFRKVELRDGMVL
                     LLSPHQQQEWHVNEVELDYTFLIFREDFMRTFIADKFFVYRLLYYYQTDTPPYLFAEPE
                     ELTEYMRLLKKIKQELQHPVVDTYNLIVSVLYYLLVIINRAYAQTYRLPVEVPKNNYAF
                     KFKDLLEKHIRTTQRVQEYADMLRVSRITLNNSVMAQFGVSAIHLLKQRLLEELKNELL
                     FSNLNVSQLADEFHFSDPSHLMRFFKRETGKTFTQYLMNYKRGIYE"
     CDS             10001..12229
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_67"
                     /sec_met_domain="Gly_radical (E-value: 4.5e-46, bitscore:
                     148.1, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1173.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKIFKDGLWSSEINVRDFVSHNITPYYGDASFLEGPTERTKA
                     VWNRCLEALAEERENNGVRSLDNVTVSTITSHKAGYIDKENELIVGLQTDELLKRAIKP
                     FGGINVVSKACHENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRMALYGIDRLIEAKKEDLHNLTGPMTEARIRLREEVAEQIKALKDMK
                     VMGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSK
                     GTITESFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESLGGRLNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNLTVLWSPELPEGFKEFCAKVSIDTSSIQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARCNLAKALLLAINGGRCENTGTVMVKNIPVLTSDTL
                     KFEEVMDNYKKVLTEIARVYNEAMNIIHYMHDKYYYEKAQMALVDTNPRINLAYGVAGL
                     SIALDSLSAIKYAKVTARRNDIGLTEGFDIEGEFPCFGNDNDKVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGVAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATDEDRIENLVTMMDGYFTKGAHHLNVNVLN
                     RDMLYDAMEHPENYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             12246..12971
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.5;
                     E-value: 1.4e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_68"
                     /sec_met_domain="Radical_SAM (E-value: 1.3e-28, bitscore:
                     92.7, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIAGKGG
                     TPTPPEEIVRMAMSQRPFFGKRGGITFSGGEPTFQAKALVPLVRELKEKGIHVCLDSNG
                     GLWNEDVEELFRLTDLVLLDIKEFNPNRHQTLTGRSNEQTIRTAAWLEEQEKPFWLRYV
                     LVPGYSDFEEDIRALGEALGKYKMIQRVEILPYHTLGVHKYEAMGQEYKMKGVKENTPE
                     QLEKAAEVFKEYFTTVVVN"
     CDS             complement(12964..13413)
                     /locus_tag="ctg37_69"
                     /transl_table=11
                     /translation="MRKISLIVIHCSATRVDCDFTAKDVDTAHRYRGFSCWGYHYYIRK
                     SGEIEPMRDEDTVGAHARGYNAISLGVCYEGGLDENGKAADTRPPRQKEALHRLVHELL
                     QRYPEAKVVGHRDLSPDTNYNGIVDPWERIKECPCFEVIGEFSIN"
     CDS             complement(13627..14130)
                     /locus_tag="ctg37_70"
                     /transl_table=11
                     /translation="MAMTVSYSVVPRKNPAKKSEPAKYYAQAQASGELDFEELCEAITS
                     RSTCTETDVRAAISGILYEVKRALKAGRIARLGDLGSLQIGLNSEGAASVKEFSGSMIK
                     GAHLIFRPGKTLAELMKILSYQQVQTRAVAQAGAGDGGGEDPDKNPDSGGDGSGDEEAP
                     DPTV"
     CDS             14324..14554
                     /locus_tag="ctg37_71"
                     /transl_table=11
                     /translation="MNYKEDSFLIRTYTKAELAHLYNPHVCLKVALQILRRWIIYNLPL
                     LHELEQEGYRARNRLLSPKQVATIIHFLGEP"
     CDS             14641..16755
                     /locus_tag="ctg37_72"
                     /transl_table=11
                     /translation="MKHFTIFQGFYYAIAEMTEEEIVSTIGSFTYREKVEEIRRIFAEQ
                     GEKAANEKKKELPAIAFSASYRGRRTKVNLVKYLGHIVIDIDHLSKEELARILPIIKRC
                     DYTRIAFISPKGMGVKIIVRACHPDETLPETLQEIEDFHHAAYTRLVSFYTELCQIEID
                     TSGQDVARTCLFSYDPEIYFNPNADAFLVDQPQASYKVSNRKNLSGSKQQTPPDGPPTN
                     EDTALNAHSANASLVLTLTYYHNKSEKYIVGNRNNYLHHLSCTFNRYGIPQEEASAFIK
                     SQFTDFPADETASLINSAYAHTDEFNTCKLNGTQKRILRIEQYISEHYETRYNEVLHIM
                     EYRRRHPDTEKPEPFRILDEMMENSIWIEINELGYACTVKTIENLIYSDFSQSYHPIRE
                     YFELLPEWDGTDYIRILADSVQTSHQEFWAECLERYLVAMCAAATQENIVNHTVLLLCS
                     EIQNIGKTTFINNLLPPELRAYLSTGLINSNNKDDLAKITQAMLINLDEFEGMSGRELN
                     AFKDLVTRKVISFRLPYARRSQNFPHTASFAGTCNYQEVLHDTTGNRRFLCFHPYSIQF
                     ITINYAQLYAQIKYLLNKPGYQYWFTQADNERLEENNEAFIFHSPEEEMVLTHIRKPER
                     FEKVYYLTVSEIAELIRERTGYQYSIGSKIQLGKVMTKHHFESKKGNNGRRYAVFIIDI
                     EQVKSNRLYE"
ORIGIN
        1 ctctgatcct caacagcctg agaaccgaga tagagaaaaa catattgatt tacgaaaaac
       61 atccattgtt tgatgatgag ataatttctc gtgtgtgcta caacttcgct ggcagatatg
      121 acgctgatat agaagcacag ctgagagtta cacaaaattt aagcaagcct ttgaatgaag
      181 catacaacag gtatgattcc attggctaca gggtacatac agcagaagaa gaaaagcaag
      241 ccgaaaagga gcatgaacgc tgcaaggctg aatatgagaa ggaaaaagaa gaactggaca
      301 ggctttatga attggaaagg caggcaagaa aggaatctct ccaatatatt gagaactgtt
      361 gcggagatat ttataaactg agtttccatt ttatggaaat attggcaaaa tatattcccg
      421 tagaaaaaga caagccggat gaaccgagca agcaagagaa acagcaggat gcgccaaagg
      481 agcaatccga atatttcgat gcaaaattac tttcgcttat tcataaagtc tgtgtggggg
      541 aacagtttga agatattgca acgcaggact tctatgccaa catgaaccta tcctcctgta
      601 aaaaggaatt aaaaatcaag gcaagggaaa agatacgggt gtgttacctg atattcctga
      661 tgagtgaaag actgcccaaa caagacagag ataaatggaa aaatataatc ctgaaacagt
      721 tggatattga cgagaactac tacaagtcaa agtacaagga accggtgtcg gattttccaa
      781 gtgacagcaa ccagaaattc gccaaagaaa tggacgcaat attccgataa tccgtgatac
      841 accctgatat tttacgaaat taccactttt accactcaaa ttaatttttg agtggtattt
      901 ttattatctg atattcagtg aaataataaa atattccatt tgcactaacc acatccttac
      961 cactcacgcc cctacctaat tttgcatcgt tcgagaacag agataacagc cagtgcgcag
     1021 ggctgattgt ttaacggcta aatagattga acgatgacaa atcttcaaga gttattatta
     1081 aaacccgtct ggcagatgac aggcgaagag ttcatattcc tgagcaagca cgcttccggt
     1141 caaacggaaa cgcaaccacg acccgttacg gacacagaaa gaaagtatgt gtacggaata
     1201 ctgggcatag ccaaactgtt cgggtgcagc ctgccaaccg ccaaccgcat caagaaaagc
     1261 ggaaagattg acaaagccat cacccagata ggacgcaaga ttatcgtgga tgtggagctt
     1321 gcccttgaac tggcaggaaa gaaaaccgga ggacggaaat aacgggagga atagctatgg
     1381 actatatgaa agaatttaag gacatatcgg cagaagaagc cgtaatcctt tggcaagcct
     1441 cacgtttgag tctgtcgaaa agttatgaga aagcacctga aatcctcaaa gtgcatggtt
     1501 ctgtcattgg gacattgggc aatttcagcg catccatcgg caaagccaaa agtaaaaaga
     1561 cattcaatgt ttcgactatc gtagccgccg cattgaagaa tggcacagtg ttgcggtatg
     1621 tagcggaact ctcctacggg aagcggaaag tgctttatgt tgatacggag caaagtcctt
     1681 atcattgcct gaaagtcatg aaacgtattt tacggatggc tgacttgcct gatgacaggg
     1741 ataatgagaa ccttgagttt ctcgccttga ggaaatacac acctgaacag cgtatcagga
     1801 ttgtcgaaca ggctatctat aatacgcccg acattggtct tgtaatcata gacggcatcc
     1861 gtgacatggt atatgacatc aacagccccg gcgaatccac acgcatcata tccaaactga
     1921 tgcagtggac ggacgacagg cagatacata tccatacgat actgcaccag aacaaagggg
     1981 atgagaatgc gagagggcat atcggcacgg agttgaacaa taaggcggaa accgtattgc
     2041 tggtggaaaa agacaaaagc aacggagata taagcaatgt ttcagccatg cacatccggg
     2101 caatggattt cgagcctttt gcctttcgta tcaatgacag tgccttgcct gaactcatag
     2161 agggttacaa acccgaagcg aagaaaccag gaagaccgga agaggaaaag ttcgaccctt
     2221 acaggcatat taccgagcag cagcaccgta tcgcattgga agccgttttc gggctgaaag
     2281 aggaatacgg ttacaaggaa ctggaagatg ccttaatcaa aagctatacg tcaataggtg
     2341 taaagctgaa ccatcaaaag gcggtaccgc tcatcaccat gcttcgcaac aaacggatga
     2401 tagtacagga gaacggcaga aaatacacat tcatgcccga cttccactat tagcctgtta
     2461 actgcaatcg cttcacttta ttctgtgggt ctatatatta aggataaagc aaagtgatgc
     2521 aaggaatgga taaaccgctt cactttattg ccgtactcta tatatacgac aatttagtga
     2581 agtggttata tagaccgtac ttcttaaaat ggtacgggcg aaaagaaaaa taaatcaatt
     2641 caccaactac tcaaacaatt atcttatgga tatacagaca accaagcaaa tcaggatagc
     2701 agattatctt cacagtttgg gatattctcc cgtcaaacaa cagggtatca acctatggta
     2761 taaatcaccg ctaagggaag aaacggaagc ctcgttcaaa gtgaatacag aacgtaacca
     2821 atggtatgat tttgcactcg gcaagggtgg aaatatcatc gcactggcgc aggaacttta
     2881 ctgttccaac catgtgccat atctcctgca aagaatcgaa gaacagacac cacatatccg
     2941 tcctgattct ttctcttttg gcaagcagtc atcttccgag ccacgttttc aacaactgga
     3001 gattgtaccg ctttcttctc ctgccctgct ttcctattta caaggtagag gaataaatct
     3061 ggagctggca aaaagagaat gtagagaagc ccgttgcacc cacaacggca agcgttactt
     3121 tgccattgcc ttccctaacg gttcgggtgg gtttgaggtt cgtaacccct atttcaaggg
     3181 ctgcatcgcc cccaaggaaa tctcccacat cagacaggcg ggaaaagcaa ggactacctg
     3241 ctatgtgttc gagggtttca tggactacct ttcctttctg acattgagac aggaaagctg
     3301 cccgaattat ccggaattgg acggacagga ctacattgta ttgaactccg tatcgaatgt
     3361 aagcaaggct ctctatcctt tgggtagcta cgaacgcatc cattgtttct ttgacaatga
     3421 ccgtgcaggg atggaagcac tccggcaaat ccgtatggaa tacggcaggg atttatacat
     3481 ccgtgacgct tcgcagacct acagcggatg caaggacttg aacgaatacc tacagaaaca
     3541 ggctgaaaga aacaggcaaa tccagtccgt aagaaagacg cacacccagc caccgaaaaa
     3601 gaagaacggc ttccggttat agcccactat aactacacgc tccgctttcg tagttgtggg
     3661 ctctcccgag gggattaggg ctttgcccta atgacccact caaggcgttt cacccctgag
     3721 aaccccgagc aaagagtgac cctctctttg caatctccgc ttatgggtta cccctaagaa
     3781 cccctctgcg aaagcgagca aaataatcaa ttgcaaacaa agaaaagaag ctatggcaac
     3841 aaaatcaagc atacatatca agccttgcaa catcgcatcg agcgaggcac acaaccgaag
     3901 gactgccgag tatatgcgta atatcgggga gtccagaatc tatgtcgttc ccgaactttc
     3961 caccgataac gaacagtgga taaatcccga cttcggcact cccgaactgc gaactcatta
     4021 tgacaatatc aagcaaatgg tcaagaacaa aaccggacgt gccatgcagg aaaaggaaag
     4081 ggaacgcaag ggaaagaatg gaaggattat caaagtggcg ggatgttcac ccatccgtga
     4141 aggagtattg cttatcagac cggacaccac actggctgat gtacgcaaat tcggtgaaga
     4201 gtgccaaaga cgctggggta tcactccact acaaattttc ctgcacaaag acgaaggaca
     4261 ttggctaaac ggtcagccgg aagcagaaga caaagagagt tttcaaatag gaagcagatg
     4321 gttcaagccg aactatcatg cccatatcgt attcgactgg atgaaccacg aaaccggaaa
     4381 gagccgaaaa ctcaatgacg aagatatggc aatcatgcag accttggctt ccgatattct
     4441 cctgatggaa cgtgggcagg caaaagctgt cacaggtaaa gagcatctgg aacgaaatga
     4501 tttcatcatt gagaagcaga aagccgaact gcaacgtata gaggaaacca agcgacacaa
     4561 ggagcaacag gtaagccttg ccgaacagga actcaaacag gtaaaagcag agatacgtac
     4621 ggacaaactc aaaagtgcag ctaccgatgt agccacagcc ataaccagca gtgtaggttc
     4681 tcttttcgga agcggtaagc tgaaagaact ggaacatcac atcgagcagc tacatcagga
     4741 aattaccaaa cgggacaaag ctactgatga attgaaaatt cagatacaac aaatacatga
     4801 acagcatggc agacaaattc gtaatcttca aggaatacac aatcaagaac ttgaagccaa
     4861 agaaaaggaa atatcacgat tgaataccat tctcgaaaaa gcattatgct ggttcccatt
     4921 gctcaaagaa atgctgagaa tggaaaaatt atgctatgtc actggtttta ccaaggggat
     4981 ggttgattct cttttataca aaaaggaagc tctcagatgt agtggaaaaa tctattccga
     5041 agaatatagg cagagatttg aaacaaaaaa tgtaattttc aaaattgaac gaagcccgat
     5101 cgataagaat aaattgatgc tgactataaa ccaacagcca atcagcgaat ggttcaagga
     5161 acaatgggag aagttacagc agcatctgcg taactcagtg cagaaagaac aaaaatccag
     5221 aggattcagg atgtaatata gagaagtaca attcatcatg gattgtactt ctatcgtaat
     5281 atatagtaca aaatctaagt tgtctaacta ttctaaagta aaataagcaa taaaagaata
     5341 tcttattcac tattaatata ccatattgtc aatatctttc cctcatttag tcaatcgtat
     5401 cttttcgtgg tagaaataat ttacgataac cggcttgcct ttttccgagc gcccgtaagg
     5461 caaatcattt attctatatg gaaatccctg tgccttggcg tattgggaaa tgtcctgttc
     5521 caatgcctgc cagtaatcaa gcctcttttt gttgtatatt tcttcgtata acggaaagag
     5581 gtcgggatgc ttctcacgga tatacgtcat tatccctccc ttgaactgcc cgcgcagatt
     5641 caggttttcg agccatatca aatcggcata tcctttcact ttctcgataa tcgccttcat
     5701 atcggttatt ccggggaata tgggcgatac gaaacacacg gtacggatgc ccgcctcata
     5761 gacctgacgc attgcgttca gacgacgttc tatgctcacg gcattgtcca tatccgtacg
     5821 aaaccgctcg tcaagcgtat tgatcgacca tgacaccgtt actttgggaa aacgcttcaa
     5881 caggtcgagg tcgcgcagga caaggtcgga cttagtgcat atcataatct cggcgttgct
     5941 cccacgcagc tcttcgagca gcctgtgggt acggcaaaat tgctcctcat acgggttgta
     6001 accatccgtc acggaaccta tcacaatgcg ctctccgtca tatttgtgcg gattggctat
     6061 cggtttccag ttcttcacgt ccagaaatgc accccacggt tctgtatgcc cggtgaatcg
     6121 tttcataaac gatgcgtagc aatacttaca ggcgtgggga cagcccacgt aagggttgac
     6181 cgaatatcct ccgaccggca gtgaggattt ggtcataacg ctctgtacgt ctatttcttt
     6241 gattatttcg gtattcattg taagcgtttt gtaaattgtt ccggcagttc ctgaatcatc
     6301 ctttcttcgc ccattatagg cagcaaatcc tctttcataa acacggggac gccctgtgtt
     6361 tgggcttggt cggcaatgtg aagcacccat tcgggacggg aatccacttt gcctttccga
     6421 tgtccggtct ccgtacctat gacaatccag tcgataccct cgaaatctat atcgccgatt
     6481 tcatcgaaaa taggttcgaa agtgacatgg tagtgcttgg ccttgatatt tcttttcaaa
     6541 tcgtctagcc gctttttttc ggaattgcgc gtgacggtca cgcccatcca tacattctcg
     6601 tcatctgtag agaaactgat cttgtccgga catttcgtaa ggaatatata agcgtgttgc
     6661 ggattgcttt tcattcgtct gaatatttct gcattccatt caggcttcca atcggagaaa
     6721 tcgctcattc cggtcatcag ccatacgtga ggcttgggcg tgtcgatgat acgcagcttt
     6781 cgcaccatat attccggtac ggagaagtcg tccgtaatat ggaagcggcg gcagttgtta
     6841 cgggcatagc agtagctgca cccgatggag cagcctacca ctatgttcat attctttatc
     6901 agggatttta tacagatagt catctgctta gagttccttt ttagaatcat ttcggagaga
     6961 ctttccattt taccggttct ttcagtatga ttccgtcagt ggcatcctcc tgtgagaatg
     7021 tattgctgca atattgtatg cagagcatga ggagcggagt cgttccgttg ttacggacac
     7081 ttcgttttcc tgcaggagat accctgacaa cgctaccttc ttccactggg aacactgttc
     7141 cgtctacttg aaattcacct ttaccggaga ggaaaaaata aagctcctca tgactcttgt
     7201 gactatgcag aaatccggtt tctgtacccg gggcgaatga ctggaaagaa aactcgcttc
     7261 ccgtagttcc gagagcggtg ctgcagaata cttttccggg gattttcaca tccgggccaa
     7321 gctgaagttc gtattcattc agttcattca acttaccgac actgatcgcg gcgaaattct
     7381 gttctaccgc gatttttcta atctttttca tctttctaat attttgaaat gattgtttat
     7441 acagttattt aagtgttatg ctttctccgt cttccggtat aatcagtcgg ctcatatccg
     7501 tcccgtgatg gcgagcttcg ttgcgcagga tggcacgggt ggtctggcaa tggtcgatag
     7561 catccatgtg tacggtaatc agcttgatgt gtgggggaag tgtgtcaagc atcgccatta
     7621 cttcctgttc attggggatg atacaaccat ccgtcttaga gaattcgggg aataccgcac
     7681 cgccactgtt caccacaata taattaggac gatacttttc cacggtagca agagtacatt
     7741 cttcccattt gcaatcgccc atgatataaa tagtcggaag cccttcggac atcagcacat
     7801 agcccgaaac aggtcccatc atctggccta tctgaccgaa accgtgatgg ccaatagcac
     7861 ggtggatggt cagatgacct aaggttatgc tctcttcaat cgtttctaca tttgagaaac
     7921 catctttcag gatggcagcc ttatcttgtg gctgggtgta gaaaggaata tctttcggca
     7981 aatgctgctt tacacttggt tcgtaatggt cgatgtggtt gtgggtgagc agtaccatat
     8041 caacaccttc agtaatgtcg ctaataggca ttacgagatg taccctcgga ttcttatata
     8101 caccgagagc tgattgcagg gttcctttgt cggcaaatac ggggtcaata agaatggtat
     8161 gtcctgcata gttgattttc aaggtggcac tgcgtaccaa ccgaataatt gctttttcgt
     8221 tcatgatgtt atgttttgta ttatttttcg ggtataaagt tcgaaaggat atcccaatgt
     8281 ctctatgcct taaaaacagg aatatatgcc attttgataa aagaatgatg tatatttgca
     8341 gaaagcaaaa aacaagagtg atgaaagcta taatcaatcc cgaaagactt gtaagcgttc
     8401 cgttcaataa aacgcaatgt ggcgtagact tctacattaa cacaggcgaa agcaaggaca
     8461 tctgtggtgt cttgaccgag cataagacgt ttaagacaga ttttttcagc ttctatttct
     8521 ttcgtcgtgc caatggatat ttgttgctga gcttccgaaa agtggagtta cgggatggta
     8581 tggtgctgct tttgtcgccg caccagcaac aggaatggca cgtgaacgag gtagaactgg
     8641 attacacttt tcttattttc cgcgaagact ttatgcgcac gttcattgct gacaagttct
     8701 tcgtatatcg gctgttgtat tattatcaga ctgatacacc gccctacttg tttgccgagc
     8761 cggaggagct gacggaatat atgcgcctct taaaaaagat aaaacaagaa ctacaacatc
     8821 ctgtggtaga cacttacaac ctcattgtgt cagtgcttta ttatctactg gtaattatca
     8881 accgggcata cgctcaaact tatcgtctac ctgtcgaagt gccaaaaaac aattacgcat
     8941 tcaaattcaa ggacttactc gaaaaacata tccgaacgac acagcgcgtt caagaatatg
     9001 ctgatatgct tcgggtaagt cgtatcacct tgaataattc tgtcatggcg caatttggtg
     9061 tatcagccat tcacttactc aagcaacgtc ttttggaaga gctgaaaaat gagctactgt
     9121 tctccaatct gaatgtgagc caactggcag acgagttcca cttttccgac cccagtcacc
     9181 tcatgcgttt tttcaaaaga gaaacaggca agacttttac ccaatatcta atgaattaca
     9241 aaagaggaat atatgaatag aaatttggca aatgaattcc atattaagat atttattttt
     9301 ttaaataacc atatttttcg tcataaaggt tcattctgtc agtccataga aataccattc
     9361 gctttgtaat tgacattctt ttgaagaatc ttaaataata caaaaacacc cagttttaca
     9421 ttcttgggtg taaaactggg tgtttatttt gcaattcgct gattttcagc gtttattgcg
     9481 gagagagagg gattcgaacc cgcgatacac ttttggcgta tacacgcttt ccaggcgtgc
     9541 ctcttcaacc actcgagcat ctctcctttc aaaaaactca ataaacacta agaaaacgct
     9601 cccgttttcg tttcacaaca tcggaggcgt cgccctccat aaaaacaaaa aagcagccca
     9661 aaagctgctt ttcagcggag agacagggat tcgaaccccg ggtacctcgc ggtacaacgg
     9721 ttttcaagac cgccgcaatc gaccactctg ccacctctcc aaaacttcct tgtcagaagt
     9781 gcttttcgtt aaaagcggtg caaaggtacg aagatatttt aaacttgcaa gagttttcac
     9841 taaaaattta atctaatctt ttcctaagga tagcaattaa taggtatttt atgttgaaaa
     9901 gcataaaata gagcatattt atgctgatta tatgaaaaat gattgtaact ttgtgcgctc
     9961 taaagaatag gataactaca acctctaatt ttatcatttt atggaattaa acaagatctt
    10021 taaagacggt ctttggagca gcgaaatcaa cgtcagagat ttcgtaagtc ataacatcac
    10081 tccgtattac ggagatgctt cattcctcga aggacctaca gaacgtacca aagccgtatg
    10141 gaaccgctgc ctcgaagcac tggcagaaga aagagaaaac aacggtgtcc gctcattaga
    10201 taatgttacc gtatcaacca tcacttccca caaggccgga tatatcgaca aggaaaacga
    10261 actgatcgtc ggcctgcaga cagacgaact tctgaaacgt gccatcaagc ctttcggagg
    10321 tatcaacgta gtcagcaaag cctgtcacga aaacggcgtg gaagtggacg accgcgtaaa
    10381 agatattttc actcactacc gcaagacgca caacgacgga gtattcgacg tatatacgga
    10441 agaaatccgt tccttccgtt cgctgggatt ccttaccgga cttcccgaca attatgcacg
    10501 cggacgcatc atcggtgact accgccgtat ggctctttac ggcatcgacc gtctgatcga
    10561 agcaaagaag gaagatttgc acaacctcac cggtccgatg acagaggccc gcatccgcct
    10621 gcgcgaagaa gtggcagaac agatcaaggc actgaaagac atgaaagtga tgggcgaata
    10681 ctacggtctc gacctgagcc gtcccgctta cacggcacaa gaagccgtac agtgggtata
    10741 tatggcttac cttgccgccg tcaaagaaca agacggtgcc gctatgtcac tgggtaacgt
    10801 ttcttctttc ctcgatatct atctggaata tgaactgagc aaaggaacca tcaccgaatc
    10861 gttcgcgcaa gagctgatcg accagtttgt catcaaactg cgtatggtcc gccacctgcg
    10921 tatgcaatca tacaacgaca tctttgcagg cgacccgacc tgggtaaccg aatctctggg
    10981 cggacgtctc aacgacggac gtaccaaagt gacaaagacc tccttccgtt ttctgcagac
    11041 attgtacaac ctcggccctt caccggaacc gaacctgacc gtactctgga gcccggaact
    11101 tccggaagga ttcaaagaat tctgtgcaaa ggtttctatc gacacttctt ctatccagta
    11161 cgaaaacgac gacctgatgc gtgaagtacg tcagtccgac gactacggaa tcgcctgctg
    11221 cgtatcatac caggaaatag gcaagcagat tcagttcttc ggtgcccgtt gcaacctggc
    11281 caaagccctg ttgcttgcca tcaacggcgg acgttgcgag aataccggta cagtcatggt
    11341 gaagaacatc cccgtactga ccagtgacac gctgaagttc gaagaagtaa tggacaacta
    11401 caaaaaagtg ctgaccgaaa tcgcccgcgt atataacgaa gcgatgaaca tcatccacta
    11461 tatgcacgac aagtattact acgagaaggc ccagatggct cttgtagata cgaacccgcg
    11521 catcaacctg gcttacggtg tagccggact ttccatcgcc ctcgattcac tgtctgccat
    11581 caaatatgcg aaagtaactg cccgccgcaa cgatatcggc ctgacagaag gtttcgacat
    11641 cgaaggagaa ttcccttgct tcggtaacga caacgacaag gtagaccacc ttggcgtaga
    11701 cctggtatac ttcttcagcg aagaattgaa gaaattgcca gtttacaaga atgcccgtcc
    11761 taccctctcc ttgctgacta tcacttccaa tgtgatgtac ggcaaaaaga ccggtgctac
    11821 tcccgacgga cgtgccaaag gtgttgcctt cgctccgggt gccaacccga tgcacggacg
    11881 cgacaagaat ggtgcgatcg cttctctgag ctctgtagcg aaacttcgtt accgtgactc
    11941 acaggacggt atcagcaaca ccttctctat cgttccgaaa tcactgggtg ctacggacga
    12001 agaccgtatc gagaacctcg taacgatgat ggacggttac ttcaccaaag gtgctcacca
    12061 cctgaacgta aacgtactga accgtgatat gctgtacgat gccatggagc atccggaaaa
    12121 ctatccgcag ctgactatcc gcgtttccgg ctatgccgta aacttcgtga agctgagccg
    12181 cgaacaccaa ctggaagtta tcagccgtag cttccacgaa cgtatgtaat ctattactct
    12241 atatgatgat aaacgtacat tcatacgaaa gtatgggaac attcgacggg ccgggcttac
    12301 ggctcgtcgt ttttcttcaa ggatgcaact tccgctgcct ctattgcgcc aatccggata
    12361 cgatagcagg aaagggaggc acgcctaccc caccggaaga aatcgtccgc atggcaatga
    12421 gccagcgccc cttcttcggg aaacgaggag gaatcacttt ctccggaggc gaaccgacgt
    12481 ttcaggcgaa agcactcgtc ccgctggtcc gcgaactgaa agaaaaaggc atccatgtct
    12541 gtctggacag caacggagga ctttggaacg aagacgtaga agaattattc agactgaccg
    12601 atcttgtgtt attggatata aaggaattca accctaaccg ccatcaaacg ctcaccggaa
    12661 gaagcaacga gcaaaccatc cgcacggccg cctggctgga agaacaggag aaacctttct
    12721 ggctacgcta cgtgctagtg cccggataca gcgattttga agaagacata cgcgcactgg
    12781 gagaagcact cggaaaatac aagatgatcc aacgggtgga aatactgcct taccatacac
    12841 tgggcgtaca taagtacgaa gcgatgggac aggaatacaa gatgaaaggg gtaaaagaaa
    12901 atacccccga acagcttgaa aaagctgcgg aggtattcaa agagtatttc actacggtgg
    12961 tagttaatta atggagaatt ctccaatgac ctcaaagcaa gggcattctt taatccgttc
    13021 ccaaggatct acgatcccat tatagttggt gtcgggactt aaatcccgat gccctactac
    13081 cttagcttcc ggataacgct gcaacaattc gtgtaccaag cgatgtagcg cctccttctg
    13141 acggggggga cgcgtatccg cagcttttcc attctcatcc agaccgccct cataacatac
    13201 acctaagctg atcgcattat agccacgtgc atgagctccg accgtatctt catcccgcat
    13261 cggctcaatc tcgcccgact tgcgtatata ataatgatat ccccagcacg aaaagccacg
    13321 ataacggtga gccgtatcca catcctttgc cgtaaagtcg caatcgacac gggtggcgga
    13381 acaatggatc acaatcagac taatctttct catgttcctt ttccctttcc gtcgttttca
    13441 ctttgcacac ctccttacaa gtagtatgat agcgcacttc tctcaccacc ctgtcccgct
    13501 ttctctttcc gaagaaagga atcagataca tgatcacatc taaaatccga cttactattt
    13561 ctttcatctt atcaaaatat taatggaagt tattctaatt cgttattacc ttgacccgtc
    13621 tgccaattat accgtagggt ccggagcctc ttcatcaccg gagccatcac caccggaatc
    13681 cggattcttg tcagggtctt ctcccccgcc atcgcctgca cccgcctgcg ccaccgcacg
    13741 agtctgcact tgctgataac tcagaatctt catcaactcc gccagcgtct taccggggcg
    13801 gaaaataaga tgcgccccct taatcattga accggaaaat tccttgaccg atgccgcacc
    13861 ttcactgttg agtcctatct gcaaactgcc caaatcgccc agtctcgcaa ttcttcctgc
    13921 cttcaacgca cgcttcactt cgtaaagaat acccgaaata gccgcacgta catccgtttc
    13981 cgtacaagta gaacgactgg tgatcgcttc gcacaactct tcaaagtcca actctcccga
    14041 cgcctgcgcc tgtgcataat actttgccgg ttcgctcttt tttgcaggat tcttgcgcgg
    14101 caccactgaa taagatactg tcattgccat aataaaataa ttttaaagtt tataatacat
    14161 aggatgcatc cccttcttgt taacagcaca aagataagga tagccggaca agccatattc
    14221 cccaacgaag tttcttgatt cccaacgaat aaaaacgaag tcaaaccttt gaataacaag
    14281 gaattttatg taactttata gcataaaaca agaagaaaac atcatgaatt acaaagaaga
    14341 ttctttcctt atccgcacct ataccaaagc ggaactggct cacctttaca atccccatgt
    14401 ctgcctcaaa gttgctttac aaatacttcg tcgttggatt atttacaacc tccctctcct
    14461 gcacgaactc gaacaggaag gctaccgcgc acgcaaccgt ctcctttcgc cgaaacaagt
    14521 ggcaactatc atacactttt tgggcgaacc gtagtaactt attgccattt tatacaaagt
    14581 tcctttacac atttccgcaa agaagttcct ttgcatcgac aaacaataat caaaataaaa
    14641 atgaaacatt tcaccatatt tcaaggtttc tactacgcaa tagcagagat gaccgaagaa
    14701 gaaatagtgt ccactatcgg cagttttacc taccgggaaa aagtcgaaga aatacgccgc
    14761 atctttgcag agcaaggaga aaaggctgcc aatgagaaga aaaaagaatt gccggcaatc
    14821 gccttctccg ccagctaccg aggaaggcgt accaaagtga acctcgtcaa atatctggga
    14881 cacatcgtga tagacatcga ccacctcagc aaagaagaat tggcacgcat cctccctatc
    14941 atcaagagat gcgattacac ccgcatcgcc tttatcagcc ccaaagggat gggcgtgaaa
    15001 atcatagtac gcgcatgcca tccggatgag acattgcccg aaacccttca ggaaatagaa
    15061 gacttccatc atgcagctta caccagactc gtttcttttt acaccgaact ctgtcagata
    15121 gaaatcgaca cctccggtca ggatgtggca cgcacttgtc tgttctctta cgatccggag
    15181 atttatttca atccgaacgc tgacgctttt cttgtagatc aacctcaggc atcctacaag
    15241 gtttcaaatc gtaaaaatct ctccggcagt aaacaacaga ctcctccgga cggccccccg
    15301 acgaatgaag acacagcgct caacgcccat tccgccaacg cttctctggt gctgacttta
    15361 acctactatc acaacaagtc cgaaaaatac atagtgggca accggaacaa ttatctgcac
    15421 catctctcat gtaccttcaa tcgctacggc attccgcagg aggaagcatc cgcctttatc
    15481 aaaagccagt ttacagactt tccggcggac gagacagcct ctttgatcaa tagcgcctac
    15541 gctcataccg acgaatttaa tacctgtaag ctaaatggca cgcagaaacg aatattacgg
    15601 atagagcaat atatcagcga gcactacgaa acacgctaca acgaagtgct gcatatcatg
    15661 gaatatcgca gaaggcatcc cgacaccgag aaaccggagc ctttccgcat cttggatgag
    15721 atgatggaaa acagtatctg gatagaaatc aacgaactgg gatatgcctg cactgtcaaa
    15781 acaatcgaaa atctgattta ctccgatttc agccagtcgt atcatcccat tcgcgagtat
    15841 tttgaattac tgcccgaatg ggacggaacc gactatatcc gtatcctggc ggatagtgtc
    15901 cagacgagtc atcaggagtt ttgggcggaa tgcctggaac gttatctggt ggcgatgtgc
    15961 gcagcggcta ctcaagagaa tattgtcaat cacacggtac ttctgctatg cagcgagata
    16021 cagaacatag gaaagactac ctttatcaat aatctcctgc ctcccgaact gcgtgcttat
    16081 ctctctaccg gactaatcaa ttcgaacaat aaagatgatt tagccaaaat aacgcaggcc
    16141 atgctgatca atctcgacga gtttgaaggg atgagcggtc gggaactgaa tgcattcaaa
    16201 gatttggtaa cgcgcaaagt gatcagtttc cgtctgcctt atgcacgccg ttcgcaaaac
    16261 ttccctcata cggcctcttt tgcaggaacc tgcaattatc aggaagtgct tcacgacacg
    16321 acaggcaacc ggcgtttcct ttgttttcat ccttattcca tccaatttat taccatcaat
    16381 tatgcgcagc tctatgctca gatcaaatat ctgctgaata agccgggata tcaatactgg
    16441 ttcacgcaag cggacaatga acggcttgaa gagaataacg aggctttcat ctttcattca
    16501 ccggaagaag aaatggttct tacgcatatc cgcaagccgg aacgtttcga gaaggtttat
    16561 tatctgactg tcagtgagat tgcggaacta atacgtgagc gtaccggtta tcagtattcc
    16621 atcggatcaa aaatacagtt ggggaaggtg atgactaagc accattttga atctaaaaaa
    16681 ggaaataacg ggcgccgata tgccgtattt attatagata tcgagcaggt aaaatcaaac
    16741 aggctgtatg aatagaagcg ggaaagcctt gtgaatatag caaaatgcag agtcatcttg
    16801 acagatactc gagggcgtaa tctgaactct gtccccaaac aattatcttt gtattatgga
    16861 tag
//
