LOCUS       gnlProkkaGDKFGCEN_90   10595 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GDKFGCEN_90.
ACCESSION   gnlProkkaGDKFGCEN_90
VERSION     gnlProkkaGDKFGCEN_90
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 12:22:10
            Original ID  :: gnl|Prokka|GDKFGCEN_90
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10595
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10595
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1281:5595]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1282..5595
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10595
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10595
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             70..1218
                     /locus_tag="ctg90_1"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             1282..2001
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_2"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.9e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2022..3323
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_3"
                     /sec_met_domain="CTP_transf_like (E-value: 2.3e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.4e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.7e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             3340..4464
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4474..5595
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg90_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg90_5"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4564..5571
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg90_5_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg90_5_Aminotran_5.1"
                     /locus_tag="ctg90_5"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5592..5735
                     /locus_tag="ctg90_6"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             5938..7422
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg90_7"
                     /sec_met_domain="Polysacc_synt (E-value: 1.6e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             7376..8635
                     /locus_tag="ctg90_8"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             8644..9393
                     /locus_tag="ctg90_9"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             9393..10433
                     /locus_tag="ctg90_10"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 cttccttcag ttctttggga atgatgattg cttctattgc taatttgata aagaaataaa
       61 tgacctatta tgattgaaaa gcaatcttat caagaaccgt tttctgaagt ggataaaagg
      121 aaagatgatg aaatggaaat agacttgatg gctatttttt ataagattat tactgttcgt
      181 ggagtactat gcaaagctgc tggagtggga gtaataattg ctatagtggt ggcattgagc
      241 attcccaagc aatatacagt aaaggttacc ctttctcctg aaatgggtaa tgcgaaggga
      301 agtaatggtt tagccggact tgctgcctcg tttttgggag atggggctct aataggggaa
      361 agcacagatg ccttgaacgc ttctctttca gcagatattg tttcttcaac tcctttttta
      421 ttggaacttt tagaaatgga agtctccgtt tctaaaaagg atgataaaat gactttgggg
      481 tcttatctcg atgaagagtc atctccttgg tgggattatc ttataggttt tccgggcata
      541 gtaataggag gagttaaatc attattcgga gaagatacgg ttcctgccag tggagggcgg
      601 caaggaacta tcgaattgac gaaagaagta aatgagaaga ttaattttct taaaaagaag
      661 attagtgcat ccattgataa gaaaaccgcc ataacgagca ttacggtcac cttacaaaat
      721 ccgcagatca ctgcggttat agcagattct gtcgttcata aattacagga atatattatt
      781 gggtatcgaa cttcaaaagt aaaagaagac tgtgcgtatt tggaacggtt gtttaaagaa
      841 cgtcagcagg aatattatgc tgctcaaaga aaatatgcgg attatgtaga cgcccatgat
      901 aatgtggttc ttcaaagtgt acgtgctgag caggagcgtt tacagaacga catgagtttg
      961 gcttatcaga tatatagtca ggttgctaat cagttgcagg tatccagagc caaagtacag
     1021 gaggaaaagc cagtctttgc agtagttgag cctgccgttg tacctttgaa accttcaggt
     1081 atgggactca aaatttatat tttattattt gtgttcctgt ccgtatctgg tactctcgtg
     1141 tgggtgtttt ttggcaaaag tctgctggct agcttgagaa aagaactgaa aaataaggag
     1201 atagaacagg ataaatgatg ctaaaacgtc gtttacaaca ttcttacatc aattaaattc
     1261 acttactata ttattaaacg aatgatacgt acagctatga taatggctgc gggcatggga
     1321 acccgttttg gccaatatac agaattgata cctaaagggt tcgtcaaagt gggaggtatt
     1381 ccaatgatag ttcgttctat tgatactttg ttatcatgtg acattgagcg aattgtaatc
     1441 ggtacaggat ataaacaaga agtttatgaa gaattgaaga cagactatcc tatgcttgaa
     1501 acctgtttta gtcctcgtta tgctgaaaca aatagtatgt atactttata taatacgcgg
     1561 gagattctgg gcaatgatga ttttttattg ttagagtcag atttgatttt tgagaaacaa
     1621 gcaataatga gcttattgga gtgtcctgcg gcagatgcaa tgctaataac tccagtgaca
     1681 aagtttcaag atcagtatta tgtggaacat gatgataatt ttcgcctttc ttcatgttct
     1741 gtcaataaga ataaactaaa cgctaaaggc gaattggtcg gcatccataa actatccggt
     1801 tccttttaca aaataatgtg tgctgattat gcgagtattg ttgatgaaca acccaatttg
     1861 ggatatgagt atgaattact acgaatatct tgttctcaat ctcctgttta tgtgcataaa
     1921 gtagaagggc tgaaatggta tgaaatcgat gacatatcag atttggaata tgcagagaaa
     1981 tatattgttc cgtattgtta attaaaataa tatatcaaat tatgagtaag acagtttata
     2041 ttgggatgac tgcggatatt atgcatccag gacttatccg cattattaat gaggctacta
     2101 aatacggtga tgttataatt ggtcttctta cagataaagc tattgcggag cataaacgcc
     2161 ttccttatct gacctatgaa caacgaaaag aggtagttca gaatattaaa ggcgtatgta
     2221 aagttgttcc tcaagaagaa tggagctatg ttgagaatct caaacgcatt aaacctgact
     2281 atataattca tggtgacgac tggaaaaccg ggcctttacg tgaagaacgt gtgcgcgtat
     2341 ttgaagtgat gaatgaacag ggaggaaagg ttatcgaaat tccatatact ttgggaatta
     2401 attcatcttc tttggataaa gatattaagg ctataggtac aacccctgat gtacgtttaa
     2461 aatcacttcg tcgtttgata aatgccaaac ccgtagttcg tattttggaa gctcatgatg
     2521 gactatgtgg cttgataatt gaaaatcagg aaatattaaa aggggataag agggaagtat
     2581 ttgacggaat gtggtctagt agccttacgg attcaaccag taaaggtaaa cctgatattg
     2641 aggcggttga tttaactacc cgattgcaag atttgaataa tattctggag tgtactacta
     2701 aacctattat ttttgatgga gatacaggtg gtaaaattga acatttcgta tttacagtac
     2761 gcactttaga acgtcatgga atttcagcta taataattga agataaagtt ggattaaaaa
     2821 agaattcatt gtttggtaca gatgttattc aaactcaaga tacaatcgaa ggtttctgta
     2881 ataagatcaa agcaggaaag gcatctcaga ttactgatga ttttatgatt atcgctcgta
     2941 ttgagagcct tatagcggga aagccggtaa gtgatgcttt agagagagct tttgcatatg
     3001 tccaagcggg agcggacggt attatgatac atagcaaaaa taagtcgggt gaagatataa
     3061 aagaattttg tttggcgttt cgaaaacagt atgctcatgt acctatcgtg gttgtgccta
     3121 ctacatatga tcatatttat gagtctgaat tgtgtgattg gggtgtgaat ataattattt
     3181 atgctaatca tatgcttcgt gccgcttatc ctgctatgat gaatgtcgca aagataatat
     3241 tagagaatga acgtgcttta gaggtgcgcg aactgtgtat gcccataaaa gaaatattgg
     3301 aactgattcc aggtactaaa taaaaagagg aatatcatta tgttaagcgt agaaaaagtt
     3361 tatgaaacgt ttctgagtca tgacgttgat ttttttacag gagttccaga ctcattacta
     3421 aaaaatattt gtgcctatat cacagaccat acttcacgtg agaaacatat catagctgct
     3481 aatgaaggtg cggctgtagg aattgcttca ggttattata tggcatcagg taaggttcct
     3541 gtggtttata tgcaaaattc cggcttgggt aatactgtta atcctctgct gtctcttgca
     3601 gatgaacaag tatacagttt tccaatgctt ttgatgattg gctggcgtgg tgaaccggga
     3661 acaaaagatg aacctcagca taaaaaacag ggtgaggtaa ctttagattt gttgaaagca
     3721 atgcggattc cttatataat tcttgattca aatgagaatg atgcatttat tcagctccat
     3781 gatatcatac aatcagcaaa aactaagaat attcctcatg caataattat tcggaaagat
     3841 gtttttggca aatataaact tcaaaaagag ttcggatgta attatccttt atctcgtgag
     3901 gatgctttgc aaatagttgt ggattatctg cctgaaaatt cagtggtcgt ttctactact
     3961 ggcaagcttt ctcgtgagtt atttgaatat cgagaaatga aagagcaagg tcatgaacat
     4021 gattttctca cggtaggctc tatgggacat agttcatcaa tctctttggg tattgctata
     4081 gcaaagcaag atagacctgt ttattgcttg gatggtgatg gagcatttat tatgcattta
     4141 ggggcaatta gtaacattgg cgatttatct cctaaaaact attatcatat tttgtttaac
     4201 aatggtgctc acgagtctgt aggaggacag cctactttag gatttagttt agatattccg
     4261 gctattgtcc gggggagcgg atataagcat acttatactg tttgtacaaa agttgaaatt
     4321 gaagaagcaa tgaagcagct tccaaagtta tgtggtcctg ttttgttgga aataaaggtt
     4381 aaaatagatt ctcgggagaa tttgggacgt cccacgacta ctcctataga gaataaggag
     4441 cattttatgg attttttaaa ataaatatat tcgatgaaaa tagaaagaaa aatattatta
     4501 aatcctgggc ctgccactac tactgacagt gtaaaaatgg cacaagttgt tccggatatt
     4561 tgtcctcgcg agaaagaatt cgcaggtatg atgaaacaac ttcgggacga tttggtcaga
     4621 gttgctcatg ggaatttgga aaaacatacc gctgtattat tttgtggctc aggaaccatc
     4681 aatattgata tatgtctaaa ttctcttctt cctgaagaca aaagggtgct tatagtgaat
     4741 aatggggcat atagtacccg tgctgtagaa gtgtgtcaat attatggttt gcctcatatt
     4801 aatttggaat tttccgttta cgaacgtcct gatttatcgg tggtggaaaa tgtgttgcaa
     4861 gaaaatcctg atatagctat ggtttatact actcatcacg agacgggtac aggaattctg
     4921 aaccctattc gcgagatggg cgctatagct cataaatatc aggctaaatt tgtcgtcgat
     4981 actacttctt ctttgggcat gattcctttt gatatagaga aagataatgt ggatttttgt
     5041 atggcatctg ctcaaaaagg acttcaagcg atgacaggtc tttcttttat tataggcaat
     5101 gaggaacaga ttaagttttc aaaaaaatat cccaagcgtt cttactattg taatctttat
     5161 ttgcagtatg agaattttga gagaacaggt gaaatgcatt ttactccacc ggtacaaact
     5221 atttacgcca ctcgtcaggc attaaatgaa tattttgaag tgggtgaaga agctaagttt
     5281 gcccgtcaca aaagagtttt tgaggctatt cattcaggta taaatgaaat tggtcttaaa
     5341 agtgtaataa agcgtgaatg gcagtcagga ctggttgtct cagttcaata cccagaagat
     5401 cccaactggg attttgagaa aatacatgat tattgttatg agcgtggatt tacgatttat
     5461 ccaggtaaga tatcaactga ggatactttt agaatctgtg ctttaggaga gatagaagta
     5521 gatgatattg agaacttctt taaagtacta aaagctgcat taaatcatta taacgtcaca
     5581 ttaccgatgt catgattgca gaaatattat tgaagattcg tcatttttat ttttcccttc
     5641 gtggtataca cttccatccg gaaagtgtta tttctggagt gcctattcgt agctttcgct
     5701 tagtaggcaa atatggcaat attaatttga ggtgatgcat taggagttct ttattcttat
     5761 aaaaaggcat cggtagttat aggagataat gtttgtgtag ggtaatttgc ttttagtggg
     5821 agagaccata ttagaattgc ggtaaggggc gaagaagata ataaccaatt agtgagaata
     5881 ttggaaaaat ataattgata tcggtaaatg tagttgtttt tatactgtat ttaagtaatg
     5941 gaaaatctaa agcagaaaac tgtatcagga ataatgtgga gcgctataga acgtttctct
     6001 ttacaaggag tacagtttat aattcaaata atattagctc gtttgttact accatcggat
     6061 tatggtatga tcgggatgtt agctattttt cttcaagtcg ctcaagtatt tatagatagc
     6121 ggttttacaa atgctttaat ccagaaaaaa gatagaactg aagaggattt tgccactgtc
     6181 ttttatttta atattcttgt cgcagtatta ttctatggta tattgttttt ttcggcttct
     6241 ttgattgcag acttttataa tatgccgact ttagttcttg taattcgttt tatagcattg
     6301 tcgttgataa taaatgcttt atcggctatt cacagaacga aattaattat ttctgtaaac
     6361 tttaaaactc aatctaaaat ttcattaggt gcagctttta tatcaggcgt gattggaata
     6421 tggatggctt atgtcggttg cggggtttgg gctttagttt ggcaaactct cttaaatagt
     6481 ataattttga caattttgtt ttactgttta gttcattgga aacctttaca tactttctcc
     6541 aaaagttctt ttgaaagatt attcaatttc ggatctaaat tattgatctc aagtcttatc
     6601 aatacagtat atcgtaatct gtataccatt gtaataggaa aaaagttttc tgttgtagag
     6661 cttggttact atacaagagc agaacaattt gctatttttc cttccaataa tttaaatgct
     6721 ttagtttcta gagtagcgta tcctatttta agttccattc aagatgatga taaatgttta
     6781 acaaacgcat atcgaaatta tatcagatta tcctcatata taatttttcc tttaatggta
     6841 ggtttacttg ttttggctaa tcctattatt agtctattgt taacagataa atggtctggg
     6901 gttgttattc ttttacagat attatgtttg gattggatgt ttgatcattt gagccaaatt
     6961 aatttgaatt tattatgggt taaaggaaga tctgatctgt cgttacgtct tgaaataata
     7021 aaaaagacga ttgctatatt cattcttttt gtgtcaattc catttgggct tgaggtgatg
     7081 tgttggggta gagttattta ctctctgata gcgacatatt tgaatacata ttatactaat
     7141 tctcttattg atttgacctt aaagttgcaa gttaaagatg tatttccaag tttaatactc
     7201 tctttcataa tgggggggat cgtttttata tgtatttctt tctttgaaac tgatatagta
     7261 aaaattgtga ttggatgtat tactgggatg tccttctata ttttactttc ttttcttttt
     7321 aagctagatt cttttttttg tattttaaca ttgatcatta aaactaaaaa catagatgaa
     7381 aatattaaaa aagatttttc aagtaatagt aaagataatt aaccattgtg tgccagttga
     7441 tagtagatca ttgtatttta ttcctcatcc taattgtaga acagataaat atgatattat
     7501 aaattattcg tcagataatg ttctcgttct gttaaattat ttgctaaaaa aagatagtgc
     7561 tgaatattat aaaatatatg ttgaaattta tgattcttct cgtatttcag aatatcaaga
     7621 atatatttat ggcataaatc ctaatattag gtgtactttt ttatgtgcat gtgttggacg
     7681 ttttttcttt aataaagtat cttttaagga tatgttgtat gccttttttt gtttttgtag
     7741 agcaagtaaa tgttttacag ctacttttta ttatgatttt tcatttaaaa aacgctctca
     7801 acagattatt tgtttggggt attatactcc attcaaagat gattatcata tgggagatca
     7861 ttcttatgat aaatttcgta atacaacatg taactcattt gattactcta ttgctacttc
     7921 ttgtttaagt gctagaataa tttcaataga ttgtggaatc tcatatgata aattcaaagt
     7981 cttaggattt cccagaaatg atttgttgat atcgaaaaat aattgcaatg ttattaaaag
     8041 agaaatttcg aaatttgcgg gatatgatgt aactaaatat atagtttata ctccaacttt
     8101 tcgtgattat gagactgtta ctgaaggtaa tttgcgttca atactcggat atgttgattg
     8161 tgatttgttg aagttatcga aaatactatt gaagtttaat gcggctttaa ttcttaaatt
     8221 acatcctttg cagaataaaa cagtcttaaa aaaagattta cccaaaggta tacttgtttt
     8281 tgaacaaaca tataaatatg gattgtatga tcttttgtca ttttcagatg gaatgattac
     8341 tgattatact tctacctatt ttgatttttt attggtaaat aagccagtca tatttaattt
     8401 ctacgatatt gaagaatatc gtagagtaag aggtttctca tttgagccaa tagaattttt
     8461 ttgtgcaggt gatattgttt acaattataa tgaattgata gatgctgtga tgggacttct
     8521 ggctgggaaa gatattcatg ctgaacatcg acgtcatatt tctttattga tgaatcaatt
     8581 tcaagatgat aattcaacaa agagaatatg tgacatattt ttaaatgaaa tataataaat
     8641 aaaatgaatt atgcatttgt ggtgcaggca cgtttaggtt ctacacgttt gcctggaaaa
     8701 atattgaaac ctttctatgg taatcaatcg attcttgact taatggttca taagctttct
     8761 gctatatcga atattccagt aattattgct acaacaaatt ctgttatcaa tgaacctatt
     8821 gaaaagaagg cacttgcatt aggggtaaag tgcttcagag gtgaggagaa tgatgtttta
     8881 aaacgattca ttgatgttgc tgaatatttt gatatacagg gtatattccg aatatgttct
     8941 gataatccat ttttagatgt acatgcggca aggcaattgg tcgaaatagc aatgaaatct
     9001 tgtaacgatt atataagttt tgatattgat ggtactccat caattaaaac tcatttcggt
     9061 ttttggggag aatttgtaac gcttgatgcg ctgaagcgag ttataggatt tactgatgat
     9121 ttattgtatc gtgaacatgt tactaattat atatatagtc atcctgaact ttttaatatt
     9181 caatggattt caggatctcc agtcgtgtca aaacatcata atattcgact cacgattgat
     9241 acgttagaag atttttctgt agcacagaga atatataggg atttacaaga aaaaagagtg
     9301 gaaatatcga tagaagtgat tgtagactat gttcgaagac atgcagaata cattcaactg
     9361 atgaaacaac aaataaaaaa aaattctaaa taatgaagaa tacttatatt attggtgaaa
     9421 tagggcagaa tcataatggt tctgttgact tggctaagtt gattattgaa ttaatctcac
     9481 gacctgtaca tgaggatgtt tttggtatgg atttcatgcc aatgaatgct gttaaaatga
     9541 ctaaaagaga tttatcagaa gaattggctg tttctcaaat gaatcaaata tatgacaatc
     9601 ctaattcttt tgggcgtact tatggtgaac atcgtgcttt tcttgagctt gatgatcaag
     9661 cgcattttga gatttataaa tatgctaagt cattaggatt agattttatc gagacgttat
     9721 gtgccaaagg atgtctgtct ttgcttaaac tgttcacacc ggataggcta aaagttgcta
     9781 gtcgtgattt gactaactta ccattgcttg aagcattagc agaaactcat attcctatta
     9841 tattatcgac aggaatggct ggtcaaagag aacttgacaa tgcattagat gtgataacga
     9901 gatatcatag taatatagct attctacatt gtgtatctca gtatccaact catccaaata
     9961 atttgaatct acgtacaata acatatttga agaagcatta caataagttt gagataggtt
    10021 tttctgatca tacaataggt atttctgctg ctacagctgc tgtagcgatg ggagcggaaa
    10081 ttatagaaaa gcatgtaaca attgatcggc atatgaaagg aacagaccag cttggctctt
    10141 taggtccaga tggggttaat cgtatgattc gagatattcg catagcagag tgttggcttg
    10201 gtactgaaga tctttatata gaaaaagggg tggagaagtc taagataaaa cttgaacgtt
    10261 ctattgccac tcgaaaatat attccagcag gtagtattat tcaagagtcg gacattcatt
    10321 tactgagtcc tggtgatggt tataaatgga tagataaaaa aaatgtaatt ggtcattttg
    10381 ctaaacaaga tatatcagcg aatgaaataa tatatcctga ttttattgaa tagatatatt
    10441 cctactgcaa cttgtattac ggtatagagt actgcctgct ataagctaag tagtgattaa
    10501 taaataaggg taaaatacta aaaaaatgaa agagataaag cttatactta cagatattga
    10561 tggcgtttgg actgatggcg gaatgtttta tgatc
//
