LOCUS       gnlProkkaNHDJAPOD_35   12873 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NHDJAPOD_35.
ACCESSION   gnlProkkaNHDJAPOD_35
VERSION     gnlProkkaNHDJAPOD_35
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 12:47:48
            Original ID  :: gnl|Prokka|NHDJAPOD_35
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12873
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12873
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3602:7873]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3603..7873
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12873
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12873
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(2..67)
                     /locus_tag="ctg35_1"
                     /transl_table=11
                     /translation="MNVLVTGAAGFIGSHVCKRLLQ"
     CDS             complement(75..944)
                     /locus_tag="ctg35_2"
                     /transl_table=11
                     /translation="MIVSSLRGGLGNQMFIYAMVKAMALRNNVPFAFNLTTDFANDEVY
                     KRKLLLSYFALDLPENKKLTFDFSYGNYYRRLSRNLGCHILHPSYRYICEERPPHFESR
                     LISSKITNAFLEGYWQSEKYFLDYKQEIKEDFVIQKKLEYTSYLELEEIKLLDKNAIMI
                     GVRRYQESDVAPGGVLEDDYYKCAMDIMASKVTSPVFFCFSQDLEWVEKHLAGKYPVRL
                     ISKKEDDSGTIDDMFLMMHFRNYIISNSSFYWWGAWLSKYDDKLVIAPGNFINKDSVPE
                     SWFKLNVR"
     CDS             complement(941..2086)
                     /locus_tag="ctg35_3"
                     /transl_table=11
                     /translation="MKILLVFIDMIRVDHLSLYNDNMEKTSLDLFFENLGGTILTNCYT
                     PAPDTPRSIACLQSGLLPYLNGCDSRVKWPRYFMKPNIETIFDIAVGLGYKVNLCATKS
                     DIETGLFKFKENENISIFTTIEDFTDTVHLSENTLSLIAIDDYHSAIDDYGGTSLGIKE
                     GQKVILYSLNNFLTPDIVNKYDYSFFFSDHGHALQSEIVMQKNKLELLSDGRTKLFMFY
                     HNINNKKIVKDSRLASILDLYASIVDLIGSGDFRQGFSFFRDSQRDILHIEDHADFRVS
                     PEQIVSQWRVISDEIDIRTNVFETLNKKGQIIDINVVKKYLDSFSPSFSYYMKQIEILK
                     MYEKMKQRKTHYFNGVKRANWWIRCYVRIINRLYILINRLK"
     CDS             complement(2090..3583)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg35_4"
                     /sec_met_domain="Polysacc_synt (E-value: 4.4e-10, bitscore:
                     32.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKKNVVKWNFVFYLLEFLYTILVGIILVPLYLKYIPKDLYGFW
                     LATGNILSILTLINPGFSDVIQQKVAYCYGLHDYKKIGLYTVSGICLTFVFSLIVLIIG
                     VVVNLLIGSIFTMQANYLYELKIAFGLMLVGTFLTINYYSFSSILYAFLSSKSIGLIVL
                     LGNSLGTLISIYLIIHGYGLIALGIASVVRGGVFLSCSVGYVIFKFRKKKIKIVFDLNN
                     VKEIFSFSIYNFLGKTGQTLLTNMNSFLTAKFVSPIDAANLRFTQTVPEFGKVLVLRFL
                     YSVAPIIPNLLAAKGLESIRIKLLNIVYFLISFIFLVCIGFYLLNEQFIYLWLGENNFS
                     GKIINFFIIILLFFSSINKVCFQFLFALGDIKKSNKILFYQSLLYLPITVFTTKFCGII
                     GLLLSGILVELLALFIFFFPKMVDILNISKIDIRKKLFVELTKISFVTVITLLIGSCVK
                     FSNPSWLLFFVEIVFIVLTFFVLLFLCSKTFRNLLSICK"
     CDS             complement(3603..4703)
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 6.2e-34.
                     Score: 109.3. Matches aSDomain:
                     nrpspksdomains_ctg35_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.5; E-value:
                     1.9e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_5"
                     /sec_met_domain="Aminotran_5 (E-value: 8.4e-31, bitscore:
                     99.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAVLKY"
     aSDomain        complement(3825..4613)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg35_5_Aminotran_5.1"
                     /evalue="6.20E-34"
                     /label="ctg35_5_Aminotran_5.1"
                     /locus_tag="ctg35_5"
                     /protein_end="293"
                     /protein_start="30"
                     /score="109.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             complement(4700..5836)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_6"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.6e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.4e-20, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             complement(5848..7125)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.2;
                     E-value: 3.7e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_7"
                     /sec_met_domain="CTP_transf_like (E-value: 2.4e-11,
                     bitscore: 36.8, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9.5e-122, bitscore:
                     398.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 4.8e-64, bitscore:
                     208.9, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHKRLPYLTYD
                     QRKEVVENIKGVFEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVREQVFEVMNA
                     QGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILEAHDGLCGL
                     IIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNILECTTKPII
                     FDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDSIEGFCDKI
                     RAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKDKSGEDIRE
                     FCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAMMNVARTIL
                     ENERAEEVRPLCMPIKEILELIPGTK"
     CDS             complement(7169..7873)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_8"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.6e-14, bitscore:
                     47.3, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIMAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIER
                     IILGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLV
                     FERKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKDALEAKGELVGI
                     HKLSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEAD
                     LSYAEEHIIRYC"
     CDS             complement(7881..9164)
                     /locus_tag="ctg35_9"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             complement(9161..9646)
                     /locus_tag="ctg35_10"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             complement(9650..10174)
                     /locus_tag="ctg35_11"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             10696..11034
                     /locus_tag="ctg35_12"
                     /transl_table=11
                     /translation="MNDNLVTIEVNGKVIFAGKADLQFSLNQKVREPLRITKGKGKLME
                     ALTESFIKGGINSMENRPIEELQETIKEYLTFEYQRKGIATEPNKRSFLSELKKYARAF
                     RKKRDKSE"
     CDS             11175..11522
                     /locus_tag="ctg35_13"
                     /transl_table=11
                     /translation="MKKNRKAVSKNEMMKGKWKRQIMLEKDYTEQCSEWMAERLEALIE
                     YMQYGHAAVAYMKQDGTFKLVKGTLVGYEKDFGKQYDPMEIKNTVVYRDVEQQRWMTFK
                     IENFMEWRAIV"
     CDS             11572..12375
                     /locus_tag="ctg35_14"
                     /transl_table=11
                     /translation="MATTYDGINYFPIAVNFMEENAMEVIEAKYGMKGLAIVLKLLCKI
                     YKEGYYIPWGEEQCLIFANKTGKEADAEEVQGIIEIMIEKGMIDRGSYAEHKVLTSEAI
                     QKVWIEATKRRKRNWTAMPYLLIKPKETCNEEKTVCTQNVEQDAGSDAKNACNTEQSKV
                     KQSREFPPSAPPRGKEEEVNATPVSMPGYAFNTMTHNYVGLMGNLERFGITDEKEIEAI
                     LRLSDYGRKGTPVWKLICSTNWSNIGAKGKYMIAALNRAKKRSGT"
ORIGIN
        1 gttgcaaaag acgcttacaa acatgcgaac ctataaatcc ggcagcaccg gttactaata
       61 cattcattaa gattttatct tacattcaat ttaaaccaag attctggtac agaatcctta
      121 tttataaaat tacctggagc aatcaccagc ttatcatcat atttcgaaag ccatgctccc
      181 caccagtaaa aagagctatt cgatattata taattacgaa aatgcatcat tagaaacata
      241 tcatctatag taccactatc atcctccttt ttacttatca aacgaacagg atattttccc
      301 gctagatgtt tttcaaccca ttctaaatct tgtgaaaaac aaaagaaaac aggagaagta
      361 acttttgatg ccataatatc catagcacat ttatagtaat catcttctaa cactccacca
      421 ggagctacat cactttcctg ataccgtcta accccaatca ttatggcatt cttatctagc
      481 aattttattt cttccaattc caaatacgat gtgtattcta attttttttg tattacaaag
      541 tcctctttta tctcttgttt ataatcaaga aaatattttt ctgactgcca atatccttcc
      601 agaaaagcat ttgtaatctt agaactaatt aaccttgatt caaagtgggg agggcgctct
      661 tcgcaaatat aacgatatga tggatgaagt atatgacaac ctaaattacg acttagcctt
      721 ctataataat tcccatatga aaaatcaaat gttaattttt tattttcagg caagtctaat
      781 gcaaaatatg ataataaaag tttcctttta taaacttcat catttgcaaa atcagtagtc
      841 aaattaaaag cgaatggtac attgtttctt aatgccatgg ccttcaccat agcgtaaata
      901 aacatttgat tccccaatcc tcctcgcaaa gatgatacaa tcatttcaat ctatttatta
      961 gtatatataa cctatttata attctaacat aacagcggat ccaccaatta gctcgcttta
     1021 ccccattaaa ataatgcgtt ttccgttgtt tcattttctc atacattttt agaatctcta
     1081 tctgtttcat ataataagaa aacgaggggg aaaaactatc taaatatttt tttaccacat
     1141 ttatatcgat tatttgtcct tttttattta aagtttcaaa tacattagtc ctaatatcta
     1201 tttcatctga aattactcgc cattgactca caatttgctc tggagacacc ctaaaatcag
     1261 catggtcctc tatatgaagt atatctcttt gactgtctct aaaaaaggaa aaaccttgcc
     1321 taaaatctcc actaccaatc aaatcaacaa tagaggcata aagatccaaa atagaagcaa
     1381 gcctagaatc ttttactatt ttcttattat taatattatg atagaacata aaaagtttag
     1441 ttcttccatc actaagtagt tctagtttat ttttttgcat gacaatttca ctctgcaaag
     1501 catgcccatg gtctgaaaag aaaaacgaat agtcgtattt atttacgata tctggagtta
     1561 gaaaattatt taaagaatat aatatcactt tctgcccttc tttaattccc aatgaggttc
     1621 ctccataatc atcaatggca gaatgataat catcaatggc aattaaggac aatgtatttt
     1681 ctgacaaatg aacagtatca gtaaaatctt caatagtagt aaatatacta atattttcat
     1741 tttctttaaa cttaaacaac cctgtttcaa tatcagattt agtcgcacac aaatttactt
     1801 tatatcctaa ccctactgca atatcaaaaa tagtttctat attaggtttc ataaaatatc
     1861 ttggccattt gacacgacta tcgcagccat tcaaataggg taataggcca ctttgcaaac
     1921 aagctatact tcttggagta tcaggtgcag gtgtataaca gttagttaga attgtacctc
     1981 ctaaattttc aaaaaacaaa tccaacgatg ttttctccat gttatcatta tataatgata
     2041 aatgatcaac acgtatcata tctataaaaa ctagtagtat cttcatcttt tatttacaaa
     2101 tagacaataa attacgaaaa gtctttgaac ataaaaacaa caaaacaaaa aatgttaata
     2161 caataaaaac aatttccaca aagaaaagta gccaactagg attagagaac ttgacacaag
     2221 aacctattaa taatgtaata accgtaacaa aagatatttt ggttaactcc acaaaaagtt
     2281 tctttctaat atctattttc gaaatattaa gaatatcaac cattttagga aagaagaaaa
     2341 tgaatagtgc caataattct actaatattc cagataacaa taaaccaatt attccacaaa
     2401 atttcgttgt aaaaacagta ataggtaaat acaacaaaga ttggtaaaat aaaatcttat
     2461 tgcttttctt tatatctcct aatgcaaaaa gaaactgaaa acagaccttg tttatagaag
     2521 aaaaaaacaa taaaataatg ataaaaaaat taattatttt ccctgaaaaa ttgttctcac
     2581 caagccataa atatataaat tgttcattca atagataaaa accaatacat actaagaaaa
     2641 taaaggaaat caaaaaatac acaatattca aaagctttat tctaatagac tccaacccct
     2701 tagctgctaa caaattagga ataataggag caacagaata taaaaatctt aaaactaaaa
     2761 ctttaccaaa ttccggcaca gtttgagtaa atctcaaatt tgcagcgtca ataggagaaa
     2821 caaacttagc agtcaagaaa gaattcatat tagtcaacaa tgtttgtcct gttttaccta
     2881 aaaaattata tatagaaaaa gaaaagatct ccttaacatt atttaaatca aatacaattt
     2941 ttattttctt ttttcgaaat ttaaatatta catagccaac actacatgac aaaaaaacac
     3001 ctcctcgaac aactgatgca attcccaaag ctattagacc atatccatgg ataataagat
     3061 aaatagatat taaagtacct aaactattgc ctagaagtac aattagcccg attgacttac
     3121 tactaagaaa agcatataat atagaagaaa aggaataata attaatagtt aaaaatgtac
     3181 caacaagcat taagccaaaa gctattttta attcatataa ataattagct tgcattgtaa
     3241 atatactacc tattaaaagg ttaactacta ctccgattat caaaacaatt aatgaaaaaa
     3301 caaacgtaag acaaatacct gaaacggtat ataatcctat ttttttataa tcatgtaatc
     3361 cataacaata tgcaactttt tgttgtatca catctgaaaa cccaggattg ataagagtta
     3421 aaatagacaa tatattacca gtagctagcc agaaaccata taaatccttt ggaatatatt
     3481 tcaaatacaa cggaaccaaa ataatcccaa ctaaaattgt atacaaaaat tccaagagat
     3541 aaaatacaaa attccatttt actacatttt ttttatcttt catatcccaa ttgacaattt
     3601 ctctagtatt ttaaaacagc ctccctcatc acctcaaaga acctctcaat atcctccaca
     3661 tcaatctctc ccaacgcaca aagccggaat gtattcgttg tggaaatctt acccgggtag
     3721 atcgtaaagc cacgttcata gcagtaatca tgaaccttat caaaatccca gaggggatca
     3781 tcaggataca atacagaaac aacaagaccc gactgccatt cacgtttgat cgcatactga
     3841 agaccaagct cttgcaaacc tttatggatg gcttcaaaga ccctcttgtg acgggcgaat
     3901 ttagcctctt cacctactgc aaaatattca tcaagagcct gacgggcagc gtaaacggtt
     3961 tgaacaggag gagtaaaatg catctcaccc gtcttctcaa agtaatcgta ttgtaaatag
     4021 aggttacaat agtaggagcg tttcggataa tcccttgaag cacgtatcag ggattcatca
     4081 cctatgataa aggaaagacc cgtcatggcc tgaaggcctt tctgagccga agccatacaa
     4141 aagtcaacat tatccttccc gatatcaaaa ggaatcatac ccagggagga agtggtgtcg
     4201 acaacaaaaa cggcaccgtg cgaatgggct atttttccga tctcacggat ggggttcaag
     4261 atacccgtac ccgtttcatg gtgcgtggta tagaccaaag cgatgtccgg attgtcggaa
     4321 agcgtctttt cgattaccga caggtcggga agttcgtaaa cggaaaactt caaatcgata
     4381 tggggaagac cgtaatattc gcagacttcc accgcacggg tgctataggc accgttattg
     4441 acaaccagaa ctttcttatc cgcaggaaga agagagttca ggcagatatc gatattgatc
     4501 gtacccgagc cgcaaaacag gacggccgta tgtttggaga ggtctccatg cgcaacgcgg
     4561 accaggtcgt cacgtaactg tttcatcata cccgcaaact ctttctcacg cggacagata
     4621 tcgggaacaa cctgcgccag ctttaccgta tccgtcgtgg tggcgggacc cggattcaaa
     4681 aggatctttc tttcgatatt catgaatgcg tatcttttaa aaatgccata aaatgctctt
     4741 tattctctac cggagtagtc gtagggcgac ccagatcatc acgtgaatcg atccggacct
     4801 taatttcaag aagaaccggg ccggacaggc cggacagctt ctcaagcgca cacgaaagcc
     4861 cttccttgtc ggaggcagtc agtacatgcg cataaccgca acctttcgct atcgaggcga
     4921 tatccagacg gaaaccgagc gtgggttgac cgccgacaga ttcatgggca ccgttgttga
     4981 aaaggacgtg cctgtaattc ttgggagaaa gatcgccgat attgctgaca gcacccatgt
     5041 gcatgataaa ggcaccgtca ccgtcaagac agtagacacg gcggtcaggc ttctcaaggg
     5101 caatccccag ggcaatggaa gaactgtgac ccatggaacc cacagttagg aaatcccttg
     5161 cgtgcccctg ccctttcgat tcacggtact cgaaaagctc acgggagagc ttgcccgtgg
     5221 tggaaaccac aatgtcattg tccccgaggt ggtcgacaac ctgcattagc gcctcctcgc
     5281 gggacagagg atagtcattc aaggcttcct gacgcaattt atattttcca aacgtatctt
     5341 tacggatgac aatcgcatgg ggaatcgacc ggctcttcgc cgagacaacc gcgtcatgga
     5401 tctgcgccag ggcctcgtct tcatccgtat ccagaattat aaaaggaatt ttcatggctt
     5461 tcagaagatc aagggtaacc tcgccctgct tcttatgctg gggttcgtct tttgtgccgg
     5521 gctcaccgcg ccagccgacc agcaaaagaa gaggaaggct gtacactttc tcgtccgcaa
     5581 gggacaagag gggattcacc gtatttccca gaccggagtt ctgcatataa accaaaggaa
     5641 cgttgccaga agccatataa taaccgcagg caatgcccac cgcggaacct tcattggcgg
     5701 cgatgatatg cttaccacgc ggagcatgat ccgtgatata ggcgcaaata ttcttcaaaa
     5761 gggaatcggg aacacccgta aagaagtcaa caccgtgatg aaggaacgta tcgtatatct
     5821 tttctacact taccataacc gtctgattta tttagtgccc ggaatcaatt ccagaatttc
     5881 cttgataggc atacaaagcg gacggacctc ctcggcgcgc tcgttttcaa ggatggtcct
     5941 ggccacgttc atcatggccg ggtaagcggc acggagaagg tggttggcgt aaatgactac
     6001 gttggcaccc cattcgtgaa gttcggattc gtgcacatgg tcataagtcg tcggaacaac
     6061 gacaatggga acatgggcgt attctttgcg gaaagtccgg cagaactcac ggatatcctc
     6121 acccgactta tccttgctgt ggatcatgat gccgtccgca cccgcctgta cataggcata
     6181 agcacgttcg agggcgtcac tcatgggttt gccggcaata aggctttcga tacgcgcaat
     6241 gatcataaag tcaccggtga cctgggcatt cttccctgct ctgatcttat cgcagaaccc
     6301 ctcgatacta tcctgagtct ggatagcgtc agtaccaaaa agggaattct tcttcagacc
     6361 gactttatct tcaatgatta ctgcagaaat gccatgacgt tccagagtgc gcacagtaaa
     6421 gacaaagtgt tcgatcttgc cacccgtgtc tccatcaaaa ataataggct tggtggtaca
     6481 ttcaaggata ttgttcaggt cctgtaaacg ggtggtaagg tcgaccgctt caatatccgg
     6541 tttaccctta ctcgtggagt cggtcaggct gctggaccac atgccgtcaa agacctcgcg
     6601 cttatccccc ttctggactt caagattctc aataatcaga ccgcaaagac cgtcgtgagc
     6661 ctccaggata cggaccacag gcttggcctg gatcaggcgg cggagggact taagacgtac
     6721 gtcaggggta gtcccgatcg ccttgatatc cttgtcgagc gaggaggagt tgatgccccg
     6781 ggtataaggg atctcgatta ccttgccccc ctgggcgttc atcacctcaa aaacctgttc
     6841 gcgcacctcg cgcaacgggc ccgttttcca gtcgtcgccg tggatgatat agtcaggctt
     6901 gagtttttcc agattcggaa catagctcca gtcctcctgg ggaacaacct caaaaacccc
     6961 cttgatattc tcaacaacct ccttacgctg atcataggta aggtaaggga ggcgtttgtg
     7021 ttcggcgatg gccttgtccg tcagcagacc gacgatgaca tcaccgtatt tagtagcttc
     7081 atgaataata tggatcagcc ccggatgcat gatatccgcg gtcataccga cataaatttt
     7141 cttgttcata tatggaaaag atttgttttt aacaatagcg gatgatgtgc tcctcggcat
     7201 acgaaaggtc ggcttcatca tcgatttcat accatttaag accctccacc ctgagcacac
     7261 ggacagggga aacggaacgg gacatgcgga gcagttcgta ttcgtaaccc agtttaggct
     7321 gggactccag gatggtcgca taatcggcgc acatccggcg gtagaaagta ttggaaagtt
     7381 tatggatacc gaccagctcg ccttttgcct caagggcgtc cttgtctacc gaacaggaag
     7441 taaggatgtg attgcggtca tattccacat aatactgatc ctggaacttg gtcagagaag
     7501 agacaagcat cacatccggg aattcgtcat ccagcagcga gaggatggcc ttgcgttcaa
     7561 aaacaaggtc cgattcaagc agcaggaaac tgtcatcgcc tatcacgtca cgcgtattgt
     7621 acagagtgta catactgtta gtatcggcat aacggggact gaaacaggtc tctatctggg
     7681 ggaaatccgc ctgaagggct tcataagcct cttttttata acccgtaccg aggatgatac
     7741 gttcgatacc gcaggaaaga agggtttcga tagagcggat aatcataggt tttccaccaa
     7801 cctccacaaa acctttgggc acaagctcgg tataatgccc gaagcgggta ccaagaccgg
     7861 cagccatgat cattgctgtt ttaatcatga atttcagagg gaattaatat aagtgaattc
     7921 aattgttgct tgaaataaca gtaaatcgca aaaatcgaca ggacagaaac aaatcctgaa
     7981 aaaagggcag tacgcatcag catgacagtc caggaaatgt cagcagaaac gaagttcttg
     8041 accataaaca cacccgtagt gcccagatag ccgaaagaat cggccaaata aataataaaa
     8101 acagccgtac taaccaccct aagggaagca atcagacgtt ctatcaggta agtgaaagga
     8161 atatacccca tatacagacc aagaccggaa agaatcatcc accaaatagg agaaagaaaa
     8221 ccgtacacat aaagcaatgt ggaaaaaacc attaaggaac cgcctgtgac ggcgatgcaa
     8281 taaatgatat taagagccaa acggttatta cggacaaaca caatcaggaa catcagtaca
     8341 aggacaaaaa cggcaatggg aacctctgtc tgagtaaaga tcattgcacc ctcaatatgg
     8401 agctccttcc aaatatcggc agcgaaagag tcacgaagct cacggaacac ggtcagggca
     8461 ccgtaaaaaa caaccagcat gcagattccc caaaagaatt gcctcaaaaa cttacgcctg
     8521 tctttaccat ccatcggagc acgtttggta cgctgtatga tatcttgctc attgggagcc
     8581 ggaatctgat tgagaagcca gctgcaaagc aacataacag ggtataccaa caaaccggtg
     8641 gtaaaaggca tccaatattc cgacacatgc aaattatcca tcacgaattg tcccaaggtt
     8701 ttcaccaaac cggaagagac tatcaaagca acgctcagcc cgacattcaa tatttcactg
     8761 atacgacgcc cttcgatata gctaaaaatg acaccccaga tcatacccag gggaagaccg
     8821 ctcagaaaaa tagaacacac cttcaaagga accggaagaa gtgcaaaacc caacaaagca
     8881 acttcggaaa aagtaagcag ccctattata taatagatgc ggtgacccgc tttcatcgaa
     8941 ggcaaaatac gaacaccgat gaacttggaa agggcgtagc cgataatctc agaaaggaca
     9001 tacaggattt tgacatcgaa tccccaaaga atctcacctt cataaatggc tgcggtaaat
     9061 ggcttacggt aggcataggc acaagtataa accagaaaaa tcaaaacgct ggcatagaga
     9121 gccaaaacgt aaaggggaga acgggaaaga aaggaacgaa tcattcgtgt agttcgctgt
     9181 acggataagg attagcttcc aaattattca aactttcagc tatttctttt tcagctttta
     9241 aaagttctcg attgctccaa ctttctatga tagtatgcgc ctctttcgcc aactcctctt
     9301 caaacacctc accataacaa taagtcaaca actggcattt caataaagta gcaggaagtt
     9361 ggtcaagcac gtcccaacaa cgattgagaa caacttgctt tttctcctcc ttgtcaccct
     9421 gattatagat ggttgcattg taacccatca ataatgccag acagatgttt gcttcctctt
     9481 cgggagtagc accacgctga ggatacaacg catcggattg ttctaaaact tctttgttca
     9541 actgacggaa atgatcggta taaataggag caccatccac acctaaatag agtaactcgt
     9601 gcgcgagact ctgtaattgt tcaatttgag aagtgagtgt attcataact taaatgacac
     9661 gtaaataact tttaggaact ttgacgctgg cgctcaatac accggcaata cgaataacaa
     9721 cataagtttt gttggcctcg ctggcaagtt cgccctcgac accacagaaa tcacctttaa
     9781 ctacctgaac cctgctacca acagataaat ggtcattatc gaaactgacg ccattcggat
     9841 ctaaatccat gacaaatatg aagtcctgca tctgtttatc aggaactatc agcatggccc
     9901 tggtaagcag gtctttcata taaaaaagct ggatattgta tttattagaa atatcacaag
     9961 catcttgctt ggtagcttgg atgaagataa gattcttaat aacagggact tccacccgtt
    10021 ttcgacgata tttcaactgc cggatgacaa actgagtggg aagatagtaa ttgagatcaa
    10081 gttcagtctt caatttttca agagagtcac gaatagcaaa ctcttgttta tctcgggtac
    10141 gggcggcaaa ccaatacttc tgttgttcag acatttacga tttatacttg gggaaatttt
    10201 cctttgtttc gggtgcgctt cgcggtttga acgagacatc ttttctcttt caaaccgtca
    10261 aattttacga aacattttta gaagttgaga acgaacgaat gtgtttcaaa aaacgttcgt
    10321 cttttgaaac agcatttttt gagttttttt cgatgaaaaa atgaatattg taaagtagct
    10381 gagcagagaa ctttttttgc tctatatgtg tttgaaaatc aacaatataa aatctttgat
    10441 aaaattttat ccactaaata ttttgtacat taaaacagac tccttacctt tgttcaatca
    10501 aacgaacgtt ttttgaaaca acgcctatat cttaagataa ataactaata acaagatcct
    10561 tacacttcaa gattctccct ttaaactaaa aaaactccgg tattctttta tatttatatt
    10621 tttttataca aactttgtcc tttcataaat tcatttaata actaacatta tggaagaaaa
    10681 aaagtagtta tctcattgaa tgataactta gtaaccatcg aagtaaatgg aaaagtaatc
    10741 tttgcgggta aagccgactt gcaattcagc ctcaatcaaa aggttagaga accactacgc
    10801 atcacaaaag gcaaaggaaa gctaatggag gcacttaccg aaagctttat caaaggcgga
    10861 atcaacagca tggaaaacag acccattgaa gaactacagg aaacaataaa agaatatctc
    10921 acctttgaat atcagcgcaa aggcattgct acagagccta ataaacgttc ttttctatca
    10981 gagctgaaaa aatatgccag agcattccgg aaaaagcgag ataaaagcga ataaccgatt
    11041 gttaaaatcc tgtaaaagtc cctttctaaa gtacttttac aggattagtc tattcaaaac
    11101 ttattaccgt actttgccac gggtaaaaat aaaagcccga caataactca ttaataaact
    11161 taaaaaaatc aattatgaaa aagaacagga aagcagtatc gaaaaacgaa atgatgaaag
    11221 gaaaatggaa aagacaaatc atgctcgaaa aggactacac agaacagtgc tccgaatgga
    11281 tggcagaacg actggaagcc ctcatagaat atatgcaata tggacatgca gccgtagctt
    11341 atatgaaaca ggacggaaca ttcaaactgg tgaaaggaac attggtggga tacgaaaaag
    11401 atttcggaaa gcagtatgat ccgatggaaa taaaaaacac agtggtctac cgggatgtgg
    11461 agcaacaaag gtggatgacc ttcaaaatag agaatttcat ggaatggaga gcgatcgtat
    11521 aggagaatct ttcagtgacc aattaatcag taacataaca acttaacaat tatggcaaca
    11581 acatacgatg gaataaatta ctttccgata gctgtgaatt ttatggaaga gaacgcaatg
    11641 gaggtaatag aagcaaaata tggcatgaaa ggactcgcga ttgtactgaa actcctatgc
    11701 aaaatatata aagaaggata ttatattccg tggggtgagg aacaatgcct tattttcgcc
    11761 aacaagacgg gaaaagaggc agacgcagaa gaggtgcagg ggattatcga gataatgatc
    11821 gagaaaggaa tgatagacag gggaagctat gcggaacata aagtactgac ctctgaagca
    11881 atacaaaaag tatggataga ggcaaccaag cgaagaaaga ggaactggac agccatgcct
    11941 tatctactga taaaaccgaa agagacatgt aatgaagaaa agaccgtctg cacgcaaaat
    12001 gtagagcagg atgcaggctc tgatgcaaaa aatgcatgca ataccgaaca aagtaaagta
    12061 aagcaaagta gagaatttcc cccctcagct cccccaaggg ggaaggaaga ggaagtcaat
    12121 gctacgccgg tcagtatgcc cggatacgca tttaatacaa tgacacacaa ctacgtggga
    12181 ttaatgggaa acctggaacg attcggaata acagacgaaa aagagatcga agcaatcctg
    12241 cgactgtcgg attacgggag aaaaggaacc cctgtatgga aactgatttg cagcacgaac
    12301 tggagtaaca tcggagcaaa aggaaaatac atgatcgcag cgttgaaccg ggcaaagaaa
    12361 agaagcggaa cctaaaaaag aacttttctg acaaacagta cattttatat tctggaaaat
    12421 gctatttgct tgcaatcaat taaagaacgc agctgttttc ctccggaaac gagcactgat
    12481 tctcaaggga ttgaaaagcg attcaaaaag cactaatacg aagttaaaat cgtgacttca
    12541 ggaagttaac ttcccgaaga tacgatttta acttcgtaaa attatgatat taacttcgta
    12601 aacaacaaga tgttaacttc gtaaacggca tcatccggac atcaaagcaa tcaaaaaaga
    12661 ttgtcagact atagtatttc aggcagttgc cagacttgta tgtgacgaat cccttctttg
    12721 gagggcaatg tggtatcgtc catagaaacg acccactttt cataattgtc ttgtatcatc
    12781 tccagcgtgt tgtacatttg ctccacttga aaatcatcat tgagcagagg tgcacattgc
    12841 aaatacacaa tgcggtcttt cttcctgcca aca
//
