LOCUS       c00066_gnlPro..         5958 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LHDDDFDO_66.
ACCESSION   c00066_gnlPro..
VERSION     c00066_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 16:24:34
            Original ID  :: gnl|Prokka|LHDDDFDO_66
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5958
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1110
                     /locus_tag="ctg66_1"
                     /transl_table=11
                     /translation="GNPTRVNDKMLSFTYERRFENHSAYPELWGIRKSIREMGSRMRRG
                     SYSEREGMRSRMSRLRDRATELEILINADLFDSARVIASTLVSSNHRLLNGRRFPTLFI
                     DEAAQALEAACWIAIRKADRVILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSA
                     VSLLKVQYRMHEAIMRFPSEWFYNGELEAAPEVRNRGILDFDTPMNWIDTSEMDFHEEF
                     VGESFGRINKQEANLLLQELEAYISRIGKARILDESIDFGLISPYKAQVQYLRSKIRGS
                     SFLRPFRSLITVNTVDGFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKL
                     VILGDATTLTKHAFYRKLIQYIRQEAVSS"
     protocluster    1..5958
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1642:5773]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1643..5773
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..5958
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..5958
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(1643..2722)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_2"
                     /sec_met_domain="IlvN (E-value: 2.1e-47, bitscore: 149.4,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.1e-40, bitscore: 127.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQVIKTKKQKKMAQLNFGGTVENVVIRDEFPLEKAREVLKNETI
                     AVIGYGVQGPGQALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTI
                     IMCLLSDAAVMSVWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGS
                     GTSLRTMFLEGRGLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTG
                     ERGSLMGAIQGLLLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCS
                     TTAQRGALDWMGPFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALR
                     ESEMWQTAVTVRKLRPENN"
     CDS             complement(2751..3494)
                     /locus_tag="ctg66_3"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKEGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGDELSFFCDEV
                     SENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             complement(3503..4057)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_4"
                     /sec_met_domain="ALS_ss_C (E-value: 3.2e-20, bitscore:
                     61.0, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKK"
     CDS             complement(4076..5773)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.4e-48, bitscore:
                     150.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTKQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRTFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNR
                     HTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQM
                     ISARYFKYTKERSIVTSGGLGTMGFGLPAAIGATFGRPDRMVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVF
                     SREELKAAIDEMLSTDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             complement(5821..5958)
                     /locus_tag="ctg66_6"
                     /transl_table=11
                     /translation="VRLTDDELSARQMTHVTRDCYVPKSLKAYASMVSSADKGAVRLID
                     "
ORIGIN
        1 ggtaacccta cacgtgttaa tgacaaaatg ctttctttca cttacgaacg ccgctttgag
       61 aatcattcgg cctaccccga actttgggga atccgaaaat cgatccgtga aatgggcagc
      121 cggatgcgtc ggggaagtta ctccgaaagg gaaggaatgc gcagccggat gagccgcctc
      181 cgcgaccgtg ccaccgaact ggaaatcctg atcaacgccg atcttttcga cagtgcccgt
      241 gtgattgctt ccacgctggt cagcagcaat caccgtttgc tcaacggacg gcgtttcccc
      301 accttattta tcgatgaagc cgcccaggca ctcgaagccg cctgttggat cgccatccga
      361 aaggccgacc gtgtgattct tgccggcgac cattgccagc tccctcctac aatcaaatgt
      421 atcgaagccg cccgtggcgg actggaccac actctaatgg aaaaggtcgt gcagcaaaaa
      481 ccttctgccg tctcgctgct caaagtgcaa taccggatgc acgaagcaat catgcgcttt
      541 ccctccgaat ggttctacaa cggagaactg gaagccgcac cggaagtgcg caaccggggt
      601 atccttgact tcgacactcc catgaactgg atagatacct cggaaatgga cttccacgaa
      661 gagtttgtag gcgagagctt cgggcgcatc aacaagcagg aagccaactt gttactgcaa
      721 gaactggaag cctatatcag ccggatcggc aaagcacgca tcctggacga gagcatcgac
      781 tttggtctga tttcgcccta caaggcgcaa gtgcaatacc tgagaagtaa aatcagagga
      841 agcagttttc tccgcccttt ccgcagcctc atcacggtca acacggtaga cggctttcag
      901 ggacaggaac gggatgtcgt ctttatcagc ctcgtccggg cgaacgagga cggacagatc
      961 ggttttctga atgatttaag acgaatgaac gtagccatta cccgcgcccg gatgaaactt
     1021 gtgattttgg gagatgcaac cactcttacc aagcatgcgt tctaccggaa actgatacag
     1081 tatatccggc aggaagcggt atcctcctga atcatcggga taaaaaaaga agcccccttt
     1141 ctcacgaaag aggactccca tttacaaaca aaacaaacaa tgttattttc ccactaaatt
     1201 ctgttccaaa agctctgtct taaattcaat ttaacgcata ctttttcctg ctacagaata
     1261 aaattctgca tcatatcaac gaatcactaa tggaacacga aatataaaaa ggacttgaaa
     1321 tggtattaca gctaccattc ggtagagaat aacttaaata tcttttaatg taacattctg
     1381 atatactatt tattaaagaa gaaatcatct tcatacgtat cgatcttctg taagtaaaaa
     1441 gtttcttcat tgcctattct gttttatttg ttgccgtaaa ggtaatcata aatgctcttt
     1501 ttcacctata ttatcagtat cttttaatct ttttttctac tttcatcctt tttctattac
     1561 tcaaaagacc ggtatctaca tagaaaaagc gggaaaatac gcttttcccg ccttttgaaa
     1621 aacttatata gtataagtct gattaattat tttccggacg aagtttacga actgtcacgg
     1681 cagtctgcca catttcgctt tcgcgcaatg ctttcagttc ttcttccagt ttctcacgat
     1741 aatccggttt ggagttagag tcgattgaaa tctgtgcttc gttaccagtc ttcacactgt
     1801 gatacaactt ttcaactacc ggtttgatag catcgtggaa ggggcccatc cagtcgagag
     1861 caccacgttg agctgtagta gagcagttag catacatcca gtccataccg ttctttgcaa
     1921 acaacggcat caatgactga gtcagctctt ctacagtttc gttgaatgct tcggaaggag
     1981 tgtgaccgtt ttcacgtaac acttcgtatt gtgccagcaa cagaccctgg atagctccca
     2041 tcaatgaacc acgttcgcct gtcaggtcgg aagtagcttc gcggatgaaa gttgtttcga
     2101 acaaataacc tgaaccgata ccgataccca atgcgattgt tctgtccata gcgttgcctg
     2161 ttgcatcctg atagatagcg taagaagagt tcaagccgcg accttcaagg aacatagtac
     2221 gcaaggatgt acccgaacct ttaggagcaa ccatgattac gtcgatatct gcaggaggaa
     2281 ctacacctgt gcgatcactc catgtaatag caaaaccatg agagaaataa agagcttttc
     2341 ctgcagtcag gtaaggcttg atagtaggcc atacagacat taccgctgca tcagacaaca
     2401 ggcacataat gatcgtacct ttttcgcaag cttcttcaat accgaacaaa gtttcacccg
     2461 gaacccatcc gtcagctacc gctttgtcat atgtctttcc ctggcgttga ccaacgatta
     2521 cattgaaacc gttatcacga aggttcagag cctgtccagg accttgtacg ccataaccga
     2581 ttacagcgat tgtttcattt ttcaatactt cacgagcttt ttccaatgga aattcatcac
     2641 ggataactac attttctaca gttccgccaa aattcaactg tgccattttt ttttgttttt
     2701 ttgttttgat gacttgcgcc atctgttatt aattgatttt atactctata ttattcaaat
     2761 atcactttgg aacggcatac tacctcgctg ccgtttttct tcacctctac atgaaactcg
     2821 ttttcactca cctcatcaca gaagaaagag agttcatctc cgaaataact ttcagccaca
     2881 tacgccattt caaaccggcg gatacgtttc gtctgataca gttctatcgg aaacaagtca
     2941 agtatgtgct cgatataacg aatactgttt acgtgtccgt taatatcgat atcactgtat
     3001 tttgccgtca gcgtcgcaac aggctgattg cttgtcacct tgatacgcga aggcttttct
     3061 atcgggcagg gttcatcgca tatataatcg acgatgcttc ctccatgcaa tgccaacaga
     3121 tcggcaggct tacgggtatt cagattgatc atcgcccata cggaacgggc atagccgatc
     3181 ttctttcctt ccttgtcaat gacggcaaag ttacggtcgg taaacagacg atagacattc
     3241 tctacccatg tctgaaccga gaacttctcg tattggtaag gcatctcatc cagctcgatc
     3301 gccagacggg aaagcaccca tgtgtaattg tcctcgttca gcgtagcaat accaaatcca
     3361 cggtcgctgg catgaaaacc tgcgcaattc agcagatgat ttcccagcac gcccattgtc
     3421 aggcgcccgt taaaatctac gtggaacggc tctgccacaa actgataagt ccctatttta
     3481 ttttcttcac tcattactcc tgttactttt tactttgctt atacttcgcc tcctgtccgt
     3541 ccaggaactc attcacacgt tcgaagcagc tggtagtaat agccacacga cccgaacgga
     3601 caaattgcaa cacacatttc aaagcccgaa gttcttcgta aagggaagta atctcttcac
     3661 tcatgccgtt cttctcgacg atagagaata ccggattcac ctctacaatg cgggcattat
     3721 atctgcggat cactttagat gcttccggag tctcctgaaa agcaggagta gataccttat
     3781 ataaggctat ctcatggaaa taaatctcgt cttccgtaaa atagtgcgcc tgaatcacat
     3841 caatcttctt ttcgatctgc ttcaccacct tttcaatagt gtccttatca gtccacgctg
     3901 tgatcgtata tttatgtact cctttaatgg aagaagcaga aacgttcaaa ctctcgatgt
     3961 ttatttgccg acgggtaaat acagcggtca cctgattcag caatccggct atattttcag
     4021 aatgaactat aatcgtatat aatgtcttat cactcataac tttctaaatt aaggattaac
     4081 attccagcaa catctgattg actgaaccgc ccggaggggt catcggcagg acattgcctt
     4141 cttctaccac acaggcttcg agcaggaacg gtccgtctgt cgagagcatt tcgtcgatgg
     4201 ccgctttcag ttcttcccgt gaaaagacac gtttggaagg aatatcgtag gcggaagcga
     4261 ttttcatgta atccggattc aacatcggag taaatgaata acggcgatta aagaacatgg
     4321 cctgccattg gcgcacgttg ccgagataat tgttgttcag gcagataatc ttcaccggag
     4381 ctttctgttc cataatcgta cccagctcct gaatgttcat ttgcagtccg ccgtcaccca
     4441 taaatacgca taccatgcgg tcgggacggc cgaaagtagc tccgatagct gccggaaggc
     4501 caaaacccat cgtgccgagt ccgcccgaag taacgatact acgttccttg gtatatttaa
     4561 agtagcgggc agagatcatc tgattctgac ctacatctgt caccaatatg gcttcgtgac
     4621 gggtcgcttc gcttaccgca cgcaccactt cgcccatact cagtgaatcc gttgcaggat
     4681 gaagttcggg acgaatgact ttttcttcct ctaccgcttc atattccttg aaactatcga
     4741 cccactcagt gtgccggttc tttttcagca gtccggtcac agcagccagc gtctttttgc
     4801 agtcgcccaa aacggcaatg tctaccttta cattcttatt tacttccgcc ggatcaatat
     4861 caaaatggat cactttcgct tgtttggcgt aagtagccag attaccggtc acacggtcgt
     4921 cgaaacgcat accgacagca atcagtacat cacatttgtt agtattgata ttcggtccca
     4981 gatttccgtg catacccagc attcctttat tcaacggatg gtcggtaggc aatgcggaaa
     5041 gtccgagcaa ggtacaacct gcgggcatat ccgccttttc gataaaggta cgcagttctt
     5101 cctgagcgct tcccagttcc actccctgtc ctaccaagac aagcgggcgt tcggcgttgt
     5161 tgatcagttc ggcggcagcc tttaccgatt cttcgtctgt atcgggaacc ggaacatagc
     5221 tgcggataaa ctcctgcttt gtcggctcgt atttcgtttt ttcaacctgc gcattcttgg
     5281 caaagtcgag taccaccgga ccgggacgac cactactggc aatgtagaaa gcacgtgcta
     5341 ttgcccaggc tacgtcttcg gcacggcgaa tctgatagct ccatttagcg attggctgag
     5401 tgatacctac gagatcgact tcctgaaaag cgtctgttcc aagaaagcct gttcccacct
     5461 gtcctgcaat gacaacgata ggcgtactgt ctatcattgc atctgcaata cctgtgatcg
     5521 tattggttgc tccagggccg cttgtcacca agcaaacacc gactttaccc gatacacggg
     5581 cgtagccttg tgccgcatgg gcagctccct gttcatggcg aaccaagata tggttcaatg
     5641 tattttgatg gtcgtacagg gcatcgaacg taggcatgat tgaaccgccg ggataaccga
     5701 aaatggtagt cactccctga tgttccagag agcgcatcat tgcctctgcg cctgttatta
     5761 agtccttact catagttctt taatggataa tggatgattc ataatggata atgaagtgga
     5821 tcagtctatt aatctcactg ctcccttatc ggcagagctt accatgctgg cgtatgcttt
     5881 caggctcttc ggcacgtaac agtcacgggt gacgtgagtc atctggcggg cagacagttc
     5941 atcatctgtt agtcgcac
//
