LOCUS       gnlProkkaGCDHOFBN_44   14314 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GCDHOFBN_44.
ACCESSION   gnlProkkaGCDHOFBN_44
VERSION     gnlProkkaGCDHOFBN_44
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 17:05:11
            Original ID  :: gnl|Prokka|GCDHOFBN_44
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 48750
            Orig. end    :: 63064
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14314
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:9314]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14314
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14314
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(224..391)
                     /locus_tag="ctg44_62"
                     /transl_table=11
                     /translation="MFFYPMFIRYFLGNSQTKDKRNRELFSTKTSEEDWYSGNKAEVKV
                     FFINWNKKKT"
     CDS             complement(459..1007)
                     /locus_tag="ctg44_63"
                     /transl_table=11
                     /translation="MFSCKITASISLTLNSRHNRLYITDRHIHTGTSQHIQANGDLTLA
                     IHINQFANKTRQGAFNHADLFATGQRGTVHADRFFRIIKHETETGHLLVRNYGRTTLAA
                     HHHVTAHSRKTQDFHAFPRVNVYEDHHRKQDGGDQLATVAPLVEFLLNGNEILDTHLVQ
                     MLGNLLFMVHPNQSNIPAF"
     CDS             1033..1347
                     /locus_tag="ctg44_64"
                     /transl_table=11
                     /translation="MLLPGGGSAGCVYLDDLSALQRSIHKQINDLYSQRGKTPEQDATL
                     CLAILQGYNVSMYANPEDEDRKRSVLQRSLTLLDVLPPSLLKQQLSAVCHGMQELCETN
                     "
     CDS             1363..3774
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 30.6;
                     E-value: 2.3e-09)"
                     /gene_kind="transport"
                     /locus_tag="ctg44_65"
                     /sec_met_domain="Poly_export (E-value: 1.7e-17, bitscore:
                     55.7, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCSMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSQSTGTDINESRLREETKENTSDMLED
                     HPTTEDLAREDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKGALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYTMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIRSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAQPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILQPYDEVYVRRSPG
                     YQAQQNVVIDGEILFGGNYAMTSREERLSDLVNKAGGPTSLAYLRGAKLTRVASAGEKK
                     RMGDVIRLMSRQLGEAMIDSLGIGVEDTFTVGIDLEKALTNPKGSADLVLREGDVVFIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPSKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             3789..4937
                     /locus_tag="ctg44_66"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             5001..5720
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_67"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.4e-16, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             5741..7042
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_68"
                     /sec_met_domain="CTP_transf_like (E-value: 1.3e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 5.5e-121, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 6.8e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             7059..8183
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_69"
                     /sec_met_domain="TPP_enzyme_N (E-value: 7.1e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.2e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             8193..9314
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg44_70_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_70"
                     /sec_met_domain="Aminotran_5 (E-value: 1e-30, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        8283..9290
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg44_70_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg44_70_Aminotran_5.1"
                     /locus_tag="ctg44_70"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             9311..9784
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_71"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             9781..11226
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_72"
                     /sec_met_domain="Polysacc_synt (E-value: 5.5e-32, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             11226..11948
                     /locus_tag="ctg44_73"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             11962..12975
                     /locus_tag="ctg44_74"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             12980..13939
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_75"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.7e-42,
                     bitscore: 135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 accggatgaa tttgtcttac gttaagaggt gcggttctgg cctgtatgtg tgatttagaa
       61 tcctgatata cagtgtttat tggtgtgtgt tacttcttag gtaacggaat gattcatggc
      121 gcaaagatgg acatatttat gaaaatacgc aaacaaaaat gaaattaatt tcttaaaatg
      181 aatcaaaagt cggcataaca gacggaaaat gacaatatcc gtgttatgtc ttttttttat
      241 tccaatttat gaaaaacacc ttcacttctg ccttatttcc tgaataccag tcctcttccg
      301 atgttttcgt tgaaaaaagt tccctgtttc gcttgtcctt tgtttgtgag ttacctaaga
      361 agtaacggat aaacatgggg taaaaaaaca tgattttaag aaaaaagaaa tcactcaatg
      421 ctgggcctat taatgggaca ggggaaggcg tagcacactc aaaacgctgg tatgttgctt
      481 tggttcggat gcaccatgaa aagaaggttt ccgagcatct ggacaagatg ggtatcgaga
      541 atttcgttcc cgttcaacag gaattccacc aatggagcga ccgtcgcaag ctggtcacct
      601 ccgtcttgct tcctatgatg gtcttcgtac acgttgaccc tagggaacgc atggaagtcc
      661 tgagtttttc tactgtgagc cgttacatgg tgatgcgcgg cgagagtagt cctgccgtaa
      721 ttcctgacga gcagatggcc cgtttccgtt tcatgcttga ttattctgaa gaatcgatca
      781 gcatgaacag tgcccctttg gcccgtggcg aaaaggtccg cgtgattaaa ggccccctga
      841 cgggtcttgt tggcgaactg gttaatgtgg atggcaagag taagatcgcc gttcgcctga
      901 atatgctggg atgtgcctgt gtggatatgc ctgtcggtta tgtagagcct attatggcgg
      961 ctgtttaagg tgagggatat ggatgctgtt attttacagg aaaacataga gggtttatta
     1021 aatttggtac gcatgctgct tcctggtggg gggagtgcag gctgcgtgta tctggatgac
     1081 ctttccgcct tacaacgatc catccacaaa cagataaacg atttatattc acaacggggg
     1141 aagacaccgg agcaggatgc taccctgtgt ttggccatcc ttcagggata taatgtgtcg
     1201 atgtacgcca atccggaaga cgaggataga aaacggtctg tcttgcagcg ttctctgacc
     1261 ctccttgatg ttcttccccc ttctcttctt aaacaacagt tgtctgcggt ctgtcacggt
     1321 atgcaggaac tgtgtgaaac caactaactt ttttatttgt caatgaaaat acaacgactt
     1381 tttagcattc tacttttttg ttctatgctg ggaagtggct cgcttatggc ccagtccatg
     1441 agtgactcac aggtactgga atatgtaaag gacggcatcc ggcaaggcaa ggaacagaaa
     1501 cagcttgctt ccgagcttgc gcgtaaaggt gtgaccaagg aacaggctat gcgtgtgaag
     1561 cagctctatg agcagcagaa caatgtaaac acctcccaat ccacgggtac ggatatcaac
     1621 gagtcccgcc ttcgtgaaga gactaaggag aatacttccg acatgctgga ggatcatccg
     1681 actacggaag atttggcccg tgaggatcag gttttcgggc gcaacatctt caatacccgc
     1741 aacctgacgt tcgagcctag tgtcaacctt gccactcctg ccaattaccg tctgggtccc
     1801 ggtgatgaag tcatcatcga tatctggggt gccagccaga acacgatccg ccagcagatc
     1861 tctcctgaag gcaccatcaa tattcagaag atcgggcctg tcaaccttag cggtatgaca
     1921 gtctccgccg ccaacgacta tctgaagggc gccctgaata agatctataa cggtctgaac
     1981 aatactaccg accctacttc cgacatccgt ctgactttgg gtaatatccg tactattcag
     2041 atcaacgtga tgggagaggt cgtgcagccg ggtacctacg ccctttcttc cttctctacc
     2101 gtcttccacg cgctttaccg tgcaggcggc gtgagtgata tcggcagcct ccgaaacgtt
     2161 cagttggtac gcaacggaaa gaatatcgcc accatcgatg tttacgaatt tatcatgaaa
     2221 ggcaacacgc aggatgacat ccgccttcag gaaggtgacg tggttatcgt ccccgcctac
     2281 gatgtcttgg taaagatcag cggcaaggta aaacgcccta tgcgtttcga aatgaagaaa
     2341 gacgagaacc ttgccacttt aatcaaatat gccggcggct ttgaagctga cgcctacacc
     2401 cgttcattac gtgttgtccg tcagaatggt gaggaatacg aagtcaacac agtcaaggat
     2461 atggactaca gcatctacac aatgcgtaac ggtgacgttg taacagccga agccatcctt
     2521 aaccgcttca caaacaaact ggaaatccgt ggcgctgtct atcgtcccgg catctaccag
     2581 ctcagcggta aactgaacac gatccgcgaa cttgtccatg aagcccaggg cctgaccggt
     2641 gacgctttcc tgaatcgtgc cgtcctttat cgccagcgtg aggatttgac cagtgaagtt
     2701 gttcagatag acatcaggtc tatcatggac ggtacttccc cgaacctcgc cctgatgaag
     2761 aatgacatcc tttacattcc gagcattcac gatctggaag atcgtggcaa tgtcacagtt
     2821 cacggtgaag tcgcccaacc ggattcctat ccctatgctg ataacatgac acttgaggat
     2881 ctgatcatcc aggccggtgg cttgaaagaa gccgcctcta ctgtccgcat tgatgtgtcg
     2941 agacgaatca agaatccccg tagtaccgcg gataatgata ctatcggtca gatgtatacc
     3001 ttctctttaa aggatggttt tgtcatcgac ggtcagcccg gttttatcct tcagccttat
     3061 gacgaagttt atgtccgtcg cagtcccggt tatcaggcgc aacagaatgt agtcattgat
     3121 ggtgaaatat tgtttggagg aaattatgcc atgaccagcc gtgaggaacg tctttccgat
     3181 ctggtgaata aagcgggtgg tcctaccagt cttgcctatc tccgtggtgc gaaattgacc
     3241 cgtgtggcaa gtgcgggtga gaagaaacgt atgggtgatg tgattcgcct gatgagcagg
     3301 caattgggtg aagccatgat tgactctttg ggtattggtg ttgaggatac ctttacggta
     3361 ggcattgatc tggagaaggc tttgactaat cctaagggta gtgccgacct tgtcctacgt
     3421 gaaggtgatg tggtctttat acctaagaat actaatactg taactatcaa tggtgctgtc
     3481 atggttccga atacggtttc ttatatgaag ggcaagaatg tggattatta cctgaatcag
     3541 gccggtggtt attctgataa tgcaaggaag agtaagaaat tcattgttta catgaatggt
     3601 caggtgacga aggttaaggg tagtggtaag aaacagattg agccgggatg tgagattatt
     3661 gtgcctagta aggctaagaa gaaaggaaac atagctaata ttttaggtta tgctacttcc
     3721 ttcagttctt tgggtatgat gattgcttct attgctaatc ttataaagaa ataatagaat
     3781 ttacttttat gtcagaacaa cgacaggata aaaacttgct ctctgaacca cacaagacag
     3841 aaagtgatga gatagaaatt gatttggtcg atatctttcg caagattatt gctattcgta
     3901 aaaaattata caaagccgtt ggaattggtt ttattattgg aataattgta gcggtaagta
     3961 tccctaaaca gtatacagta aaggttaccc tttctcctga aatgggtaat gcgaagggga
     4021 gtaatggttt agccggactt gctgcctcgt ttttaggaga tggggctcta ataggggaaa
     4081 gcacagatgc cttgaacgct tctctttcag cagatattgt ttcttcaact ccttttttat
     4141 tggaactttt agaaatggaa gtctccgttt ctaaaaagga tgataaaatg actttggggt
     4201 cttatctcga tgaagagtca tctccttggt gggattatct tataggtttt ccgggcatag
     4261 taataggagg agttaaatca ttattcggag aagatacggt tcctgccagt ggagggcggc
     4321 aaggaactat cgaattgacg aaagaagtaa atgagaagat taattttctt aaaaagaaga
     4381 ttagtgcatc cattgataag aaaaccgcca taacgagcat tacggtcacc ttacaaaatc
     4441 cgcagatcac tgcggttata gcagattctg tcgttcataa attacaggaa tatattattg
     4501 ggtatcgaac ttcaaaagta aaagaagact gtgcgtattt ggaacggttg tttaaagaac
     4561 gtcagcagga atattatgct gctcaaagaa aatatgcgga ttatgtagac gcccatgata
     4621 atgtggttct tcaaagtgta cgtgctgagc aggagcgttt acagaacgac atgagtttgg
     4681 cttatcagat atatagtcag gttgctaatc agttgcaggt atccagagcc aaagtacagg
     4741 aggaaaagcc agtctttgca gtagttgagc ctgccgttgt acctttgaaa ccttcaggta
     4801 tgggactcaa aatttatatt ttattatttg tgttcctgtc cgtatctggt actctcgtgt
     4861 gggtgctttt tggcaaaagt ctgctggcta gcttgagaaa agaactgaaa aataaggaga
     4921 tagaacagga taaatgatgc taaaacgtcg tttacaacat tcttatatca attaaattca
     4981 cttactatat tattaaacga atgatacgta cagctatgat aatggctgcg ggcatgggaa
     5041 cccgttttgg ccaatataca gaattgatac ctaaagggtt cgtcaaagtg ggaggtattc
     5101 caatgatagt tcgttctatt gatactttgt tatcatgtgg cattgagcga attgtaatcg
     5161 gtacaggata taaacaagaa gtttatgaag aattgaagac agactatcct atgcttgaaa
     5221 cctgttttag tcctcgttat gctgaaacaa atagtatgta tactttatat aatacgcggg
     5281 agattctggg caatgatgat tttttattgt tagagtcaga tttgattttt gagaaacaag
     5341 caataatgag cttattggag tgtcctgcgg cagatgcaat gctaatagct ccagtgacaa
     5401 agtttcaaga tcagtattat gtggaacatg atgataattt tcgcctttct tcatgttctg
     5461 tcaataagaa taaactaaac gctaaaggcg aattggtcgg catccataaa ctatccggtt
     5521 ccttttacaa aataatgtgt gctgattatg cgagtattgt tgatgaacaa cccaatttgg
     5581 gatatgagta tgaattacta cgaatatctt gttctcaatc tcctgtttat gtgcataaag
     5641 tagaagggct gaaatggtat gaaatcgatg acatatcaga tttggaatat gcagagaaat
     5701 atattgttcc gtattgttaa ttaaaataat atatcaaatt atgagtaaga cagtttatat
     5761 tgggatgact gcggatatta tgcatccagg acttatccgc attattaatg aggctactaa
     5821 atacggtgat gttataattg gtcttcttac agataaagct attgcggagc ataaacgcct
     5881 tccttatctg acctatgaac aacgaaaaga ggtagttcag aatattaaag gcgtatgtaa
     5941 agttgttcct caagaagaat ggagctatgt tgagaatctc aaacgcatta aacctgacta
     6001 tataattcat ggtgacgact ggaaaaccgg gcctttacgt gaagaacgtg tgcgcgtatt
     6061 tgaagtgatg aatgaacagg gaggaaaggt tatcgaaatt ccatatactt tgggaattaa
     6121 ttcatcttct ttggataaag atattaaggc tataggtaca acccccgatg tacgtttaaa
     6181 atcacttcgt cgtttgataa atgccaaacc cgtagttcgt attttggaag ctcatgatgg
     6241 actatgtggc ttgataattg aaaatcagga aatattaaaa ggggataaga gggaagtatt
     6301 tgacggaatg tggtctagta gccttacgga ttcaaccagt aaaggtaaac ctgatattga
     6361 ggcggttgat ttaactaccc gattgcaaga tttgaataat attctggagt gtactactaa
     6421 acctattatt tttgatggag atacaggtgg taaaattgaa catttcgtat ttacagtacg
     6481 cactttagaa cgtcatggaa tctcagctat aataattgaa gataaagttg gattaaaaaa
     6541 gaattcattg tttggtacgg atgttattca aactcaagat acaatcgaag gtttctgtaa
     6601 taagatcaaa gcaggaaagg catctcagat tactgatgat tttatgatta tcgctcgtat
     6661 tgagagcctt atagcgggaa agccggtaag tgatgcttta gagagagctt ttgcatatgt
     6721 ccaagcggga gcggacggta ttatgataca tagcaaaaat aagtcgggtg aagatataaa
     6781 agaattttgt ttggcgtttc gaaaacagta tgctcatgta cctatcgtgg ttgtgcctac
     6841 tacatatgat catatttatg agtctgaatt gtgtgattgg ggtgtgaata taattattta
     6901 tgctaatcat atgcttcgtg ccgcttatcc tgctatgatg aatgtcgcaa agacaatatt
     6961 agagaatgaa cgtgctttag aggtgcgcga actgtgtatg cccataaagg aaatattgga
     7021 actgattccg ggtactaaat aaaaagagga atatcattat gttaagcgta gaaaaagttt
     7081 atgaaacgtt tctgagtcat gacgttgatt tttttacagg agttccagac tcattactaa
     7141 aaaatatttg tgcctatatc acagaccata cttcacgtga gaaacatatc atagctgcta
     7201 atgaaggtgc ggctgtagga attgcttcag gttattatat ggcatcaggt aaggttcctg
     7261 tggtttatat gcaaaattcc ggcttgggta atactgttaa tcctctgctg tctcttgcag
     7321 atgaacaagt atacagtttt ccaatgcttt tgatgattgg ctggcgtggt gaaccgggaa
     7381 caaaagatga acctcagcat aaaaaacagg gtgaggtaac tttagatttg ttgaaagcaa
     7441 tgcggattcc ttatataatt cttgattcaa atgagaatga tgcatttatt cagctccatg
     7501 atatcataca atcagcaaaa actaagaata ttcctcatgc aataattatt cggaaagatg
     7561 tttttggcaa atataaactt caaaaagagt tcggatgtaa ttatccttta tctcgtgagg
     7621 atgctttgca aatagttgtg gattatctgc ctgaaaattc agtggtcgtt tctactactg
     7681 gcaagctttc tcgtgagtta tttgaatatc gagaaatgaa agagcaaggt catgaacatg
     7741 attttctcac ggtaggctct atgggacata gttcatcaat ctctttgggt attgctatag
     7801 caaagcaaga tagacctgtt tattgcttgg atggtgatgg agcatttatt atgcatttag
     7861 gggcaattag taacattggc gatttatctc ctaaaaacta ttatcatatt ttgtttaaca
     7921 atggtgctca cgagtctgta ggaggacagc ctactttagg atttagttta gatattccgg
     7981 ctattgtccg ggggagcgga tataagcata cttatactgt ttgtacaaaa gttgaaattg
     8041 aagaagcaat gaagcagctt ccaaagttat gtggtcctgt tttgttggaa ataaaggtta
     8101 aaatagattc tcgggagaat ttgggacgtc ccacgactac tcctatagag aataaggagc
     8161 attttatgga ttttttaaaa taaatatatt cgatgaaaat agaaagaaaa atattattaa
     8221 atcctgggcc tgccactact actgacagtg taaaaatggc acaagttgtt ccggatattt
     8281 gtcctcgcga gaaagaattc gcaggtatga tgaaacaact tcgggacgat ttggtcagag
     8341 ttgctcatgg gaatttggaa aaacataccg ctgtattatt ttgtggctca ggaaccatca
     8401 atattgatat atgtctaaat tctcttcttc ctgaagacaa aagggtgctt atagtgaata
     8461 atggggcata tagtacccgt gctgtagaag tgtgtcaata ttatggtttg cctcatatta
     8521 atttggaatt ttccgtttac gaacgtcctg atttatcggt ggtggaaaat gtgttgcaag
     8581 aaaatcctga tatagctatg gtttatacta ctcatcacga gacgggtaca ggaattctga
     8641 accctattcg cgagatgggc gctatagctc ataaatatca ggctaaattt gtcgtcgata
     8701 ctacttcttc tttgggcatg attccttttg atatagagaa agataatgtg gatttttgta
     8761 tggcatctgc tcaaaaagga cttcaagcga tgacaggtct ttcttttatt ataggcaatg
     8821 aggaacagat taagttttca aaaaaatatc ccaagcgttc ttactattgt aatctttatt
     8881 tgcagtatga gaattttgag agaacaggtg aaatgcattt tactccaccg gtacaaacta
     8941 tttacgccac tcgtcaggca ttaaatgaat attttgaagt gggcgaagaa gctaagtttg
     9001 cccgtcacaa aagagttttt gaggctattc attcaggtat aaatgaaatt ggtcttaaaa
     9061 gtgtaataaa gcgtgaatgg cagtcaggac tggttgtctc agttcaatac ccagaagatc
     9121 ccaactggga ttttgagaaa atacatgatt attgttatga gcgtggattt acgatttatc
     9181 caggtaagat atcaactgag gatactttta gaatctgtgc tttaggagag atagaagtag
     9241 atgatattga gaacttcttt aaagtactaa aagctgcatt aaatcattat aacgtcacat
     9301 taccgatgtc atgattgcag aaatattatt gaagattcgt catttttatt tttcccttcg
     9361 tggtatacac ttccatccgg aaagtgttat ttctggagtg cctattcgta gctttcgctt
     9421 agtaggcaaa tatagcaata tctacttagg taaaaatgct gaaatacgtt caggctgtta
     9481 tctgattgct cgtgataaaa tcattattgg agaaaactca acactcgcct atggaacgac
     9541 tatattgaca actgctgatc ctaatggacc gtataatgca ttagcagttc tttatcctta
     9601 taaaaaggca ccggtagtta taggagataa tgtttggatt ggggctaatg ttaccatcct
     9661 tcctggagta actattggtg attacgttgt agtagcagct ggagctgttg taacaaaaga
     9721 tgtaccttca ggagtattgg tagctggtgt accagctatt gtgaaaaaac gttttaataa
     9781 atgaaagaaa aaacttcttt aaagaacaaa gccatatgtg gaatcttttg gagtgcagtt
     9841 gaacgatttt tatcacaggg gatacagttt gtagttacag tcattatggc gcgttttcta
     9901 ttgccatctg attatggaat ggtaggaatg ttagcaatag ttcttcaatt atctcaaacg
     9961 ttaatggata gtggttttac taatgccctt attcgttata aggaacgtac tgaaattgat
    10021 tattcaacag ttttcttttt taatatatta gcatcattag ttatttattt tctaattttt
    10081 tttctagctc cttatatatc gtggttttat aaaataggtc aattagttga gattactaga
    10141 attttatcta ttgttattgt tttaaattcc tttgcgatta ttcctaaaac taaattaata
    10201 atagctgtag attttaaaac tcaatcaaaa gtctcattta ttgcagcttt ggtttcaggt
    10261 attattggca tttgggctgc atatttagat tttggagttt gggctttagt tggacaaact
    10321 ttagtaaacg gattgttgat tgtagttttg tatgcatatt tttgtagatg gaaaccattg
    10381 tggatatttt cattgaaatc gtttcgttta ttatttgctt ttgggtcaaa attagtatta
    10441 gctaatattc ttaatacttt atataaaaat ctgtatgcta tagttatagg aaagaagttt
    10501 tcgtcggttg atttaggatt ttatactcgt gcggaacaat ttgctcagtt tccttcatat
    10561 aatttgagtg caataatttc tagagtgaca taccccatat tgagccttgt gcaaaatgat
    10621 aatgatagat tatctgcttt atataggaaa tatgtccgtt tatcttctgc ttttatcttt
    10681 ccattgatga ttttgttaat tgtcatagct cagccactgg tattattgct tttgacagaa
    10741 aaatggatag gagtagttgt attgcttcaa atattgtgtt tagattggat gtttgatcat
    10801 ttgagtagta taaatttgaa tttactatat gtaaagggac gttcagactt ggctttacgt
    10861 ttagaagtta taaaaaaagt gttagcgacg gggatccttc ttctatctat tccttggggg
    10921 attgtaggta tgtgttgggg gcgtgttatg tattcattga ttgctgtgta tttgaatact
    10981 tattatacag aatcattgat taaattaagt cttattagac agatgagaga tatactacca
    11041 agcttttttt tagcattaat aatgggagga ggtacttggt atatgatttt attgttagag
    11101 ggtgaaattg ttcaaattgt agtaggaagt gttattgctt tattgctata tggaacgttg
    11161 ttgtattgct tttctcgatc cttgtttgat gaaatatggg cggttatatt aaaaataaaa
    11221 aggtaatgga taaactgagt ttgattatta gtaaaatacg acggaatcat tggtatagaa
    11281 cctatatgcg tcctatatat ttatttgttt atggcaatag aaaattgaag aatagaaata
    11341 gaatattttt gcagtattca caagagctgc taactaactt tcatcaagca atgaatgaag
    11401 tgggaattcc ttattggtta gaatttggaa ctcttttagg tgctgttaga gaacacagtt
    11461 ttataagtca tgattttgat cttgatgtgg gcctttttaa ggaagattat tcagatataa
    11521 taagagaggt cttaaaaaaa tatggtttca aaagaataag gtgtataacc gcccttgatt
    11581 ttattgatgc ttatgaggaa acttatcttt ataaaggtgt gacaattgat cttttccttt
    11641 tttcaagaga gaaaaattgt gatggggtct attgttatga ttttgttcca gtatattcag
    11701 atataaagag aactaaaaaa ggtgataatg caatccggag aattcatttt cctagaattg
    11761 atttgattga atattcattt attggaatta atacttttgt tcctgaaaat tatgaggaac
    11821 atctttgtat gcattatggt aaagactata tgattccaaa tcctcattgg aaagattcag
    11881 atgcgcaaca tactgatatc ttttatggta gagagattag aattgaattg tttgataaaa
    11941 gtaaataata gtagataata catgttctat ctattttttt tactaattgt gctatttttg
    12001 ttatatatac aaagtaggaa aagacaatat tctactgtag cgggaatttg tgttcctatt
    12061 attataattt ttgttgtaat ttgtcgttat agagtggggt atgactattt aacgtattat
    12121 acattaattg aaaatgaaga agaggcacag attttatact tattttctcc tttaagcatt
    12181 gtttgggcag agattgcttt atattttgaa tctccacaga tgttatttgt tctttttggg
    12241 cttccaacat ttgctcttct aatatttact ttaaaaaaat attcaaaaga ttatgcgtta
    12301 tcagtaacta ttttaatttg tttcttcttt tttacatcac tcagtattat tcgacaagct
    12361 ttggctttgg ctatttgttt ttatggttat cgttttatag taaaacgttc actaattaaa
    12421 tatatattat gtatattgat tgcagcttta ttccatcctt ctgcaggagt agcgattatt
    12481 atatattggt tgccatttct aaagtttaga ttagttgtat tattatctat aatatcaata
    12541 gtagccaaac ctttattttt ttatatgcta aatatattag gggtgtatac ctcttatctt
    12601 gatggcaaga tggatattga aggtgggaaa tatactcaat taatatactt tttgttgttt
    12661 attatttgtt ttgttttggg aagtaaaaac atagataaaa acaagtgtaa tttatttaat
    12721 gttttattgt taagttttgt tttcgtatct tttttaggag ctcatttagg cgggagaata
    12781 gcgttttatt ttaatatata ttattgtttg ttgattccta aagtggttaa aggattggat
    12841 gggcaactaa gagagcaagt gaagcttctt tcttattttc tatgtatttc ttatttctta
    12901 ttgtacctat tcgttccatt cataaaaggt gtaccctcat attatatccc atataagttt
    12961 atatttttca aatagtaaaa tgttgatatc tataattgtc ccttgttata attctgaaag
    13021 atatttgtct gattgtttat tgtctatatt gaatcaaacc tatgttaatt gggaggtgat
    13081 ttgtatagat gatggaagtc aagataatac attatctatt ttaaatcatt acgctacatt
    13141 ggatgagcgt tttaaaatta tttctcagtc taatgcagga gtgtctgtcg caagaaataa
    13201 ggctctatcc cagtgtcaag gagagtatat ttgctttgtt gatagtgatg acctgataga
    13261 acctaatttt ttgataacac ttttacagct tataagtcat caggctgatt tggcaatctg
    13321 tggttttact cgttctatgg ttttctgtat ggatgatgct caaggatata tagaaatgag
    13381 tggtaaacgt tgtatagaaa gaattattct agataaaagt ttcaatcctc agatttgttg
    13441 tatgttattt cgacataata ttataaaaga gaaacaatta gaatttgtga tagggtgtac
    13501 tcgtggtgaa gatcgtgaat ttatattgaa atatttagtt tattctaata aggtttgtta
    13561 tacaaacaat cttctttatc actatcgtgt aaatgatcag tcagccatgg caatcttttc
    13621 tattaaaagt ttgacaagta tagaagcttc acaacgcacg gtcaactact ataaaaaagt
    13681 gaattattct gttagagggc ttgaatttga attttcacgt acattgtgga aattcatgat
    13741 tttagctatt ttgtctgggc aaaatgattt atatcaaatc attcgagaaa agtatgatct
    13801 aaaaagacaa atggaacatc tttattctca tccaggacta tccgaaaaac ttacagcgag
    13861 attgtttgtt tggaatgagg cactttttaa atgggtattt tctattatta gatatctata
    13921 taaaaaaaga tggagatgaa taaacgaaat agattatctg aacaagaaat aaaaaaagta
    13981 gaacttgacg ctttattgta tattcggaaa atttgtcagc aatatcatct tcgctattat
    14041 ttagcttggg gtactttgtt gggagccgtt aggcataaag gatttattcc ttgggatgat
    14101 gatattgata taatgatgcc acgttcagat tatgagcgat tattggagtt agttccttcc
    14161 ttgagacata gttattataa aatcttaagt aatccaaaga atgaggatta ttattatact
    14221 catgcaaaaa tgatagatac tcgtactttg tgtgtggaaa atgatttgca aactattcaa
    14281 aatatgggga tttgggttga tattttcccc ttag
//
