LOCUS       c00020_gnlPro..        14169 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MDAFDENC_20.
ACCESSION   c00020_gnlPro..
VERSION     c00020_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 17:36:07
            Original ID  :: gnl|Prokka|MDAFDENC_20
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 258980
            Orig. end    :: 273149
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14169
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[268980:273048]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14068
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14169
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14169
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="2"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(238..462)
                     /locus_tag="ctg20_241"
                     /transl_table=11
                     /translation="MKDFLYFPSMTKGSLALLYFPGSNPRIATRHLMRWINGCPPLMEE
                     LSATGYYTSQKVFTSRQVTLINRHLGSPG"
     CDS             complement(480..2423)
                     /locus_tag="ctg20_242"
                     /transl_table=11
                     /translation="MNDSISILEQLVTAIEQAGVNVAPTYQEYMPLAFAIANTCGEEGR
                     TRFHRICRISEKYHHDEADKLYGHALTKGTGRNSLGTVFHLAEVAGVKMDPKLANLQNL
                     QSLHTHTRARVSYNAHPDASDGTPPDAVFTDTASPLSDGVPKAILPARLPSFPDYRWPA
                     FLQGIIDCGNSPAQRDILLLGAATVLGSTLNKLVSFVYGRKHKYPCLQVFVTAPPASGK
                     GALTWVRRLAEPIHNALLDTYREKIKTYRMEKTKWDTLGKEKVNTPEPEQPQLKMLLIA
                     GDNTGTGIQENLMDSGGVGLICETEADTVSTAIGGDHGHWSDLLRKCFDHDRLAYNRRT
                     NHEYRECNVTFLCVLLSGTPAQIKPLIPSAENGLFSRQLFYYMPAIEEWEDQFNEADTD
                     YDSRFLEWGAQWKEVLNAITASVSNINMKLTHEQKEIFNFHFARVFGRASAIHGNQMKS
                     AVTRIAINIFRIISIIALLRSLESLLPGGERSGEPQENIVRTLLNCPGLTPSAHIPQEN
                     IADGIVPQFNLSIRTDDFYAVLALVEPLYRHACHILSLLPAGTPTAPSANMTPETLFDC
                     LPLRFTRNEAIDKGEQVGVPAGSVDSLLKRMTERGQLVKVGRGEYEFNARMHTRTCVGV
                     RESASSASLQDS"
     CDS             complement(2427..2996)
                     /locus_tag="ctg20_243"
                     /transl_table=11
                     /translation="MKEYIMSFFNAPVTNKIPTCICSVAGLHTYISTNPQLEELTHKVR
                     AGLGDKQAFRKNKQTLLPYVTPAGIFSYCKEQCMQVPSGLFVIDIDELASTEEAAMWRD
                     RLFADEVLHPVLSFVSPGNQGVKLFIPYRINPFLSVEESFDNALHTAWEYLEWKYELKV
                     DRANADLSRACFLSHDGEAKINNHKY"
     CDS             3182..3649
                     /locus_tag="ctg20_244"
                     /transl_table=11
                     /translation="MNEKPDMMINIYGGNNLIAPVASSAIQNFYGDRGDEAADQPEDSE
                     KTESTESVTDEKPAQEPAELSDDEFYVSVYIPDIKVMRAYKILLGECTTARELAVVVGK
                     MLADENCRNVDKHTVVKAAFIKSLLPFAKRLVSGGTIANIRAQINNMLASK"
     CDS             3705..5984
                     /locus_tag="ctg20_245"
                     /transl_table=11
                     /translation="MLRDYQIEMKTRLMEAWKAHRSVMVQMPTGTGKTHLLASVVSEFV
                     SSAGSGIWLIAHRRELVAQMEETLAKYGIRREDTPVRVMSVQWLSRHWNEAGDAPGLIV
                     IDEAHHALSASYTEMWKRYPAAKKLGVTATPCRLNRRGFTELFEVLVTSWSIAEFIEKG
                     VLSVFDYVSIRPGSEEQRLIDGLEKRGADGDYQVKEMDAVLNRRPGIERLYRSVRQFAS
                     GKKGMVYAISIEHARRIAEYYSRRGVNAVAVDSKTPAMERKRMVEEFRHGKIEVLVNVD
                     VFSEGFDCPDVEFVQLARPTLSLAKYLQQVGRGLRRSEGKEACMLIDNVGLYRIFGLPT
                     QRWNWDAMFRGRMAGKGSLPGRMNCDASVTAFPVVERPAEAGGDLVMVMEHGRLLSSIR
                     EQALPDEKEQSPSCRLRAFVDKETGLWGLEKGDEMLPDVSFKEILSIKGRFAVGRLRNG
                     CVRVLDDTGALVAELGHCREVRLLKDDLLQVRHAGNSVSYVDLRNGRCYAVRPRVLRYG
                     SIELLQVNRTYYSRTRQVYANTCGLPSSSIVWMGFYVKMYDGRVPSRCRRMEDGGFCCE
                     PQVCLLEGDEERAYYLSGRLPDQSIVVMDEEGRYYHVEKGHGKRYVACNRPSDRSEDFD
                     EAVALLRRQADERVEKHLQEEKCETERKRQRIISRSVEAVPFQIGVKWGLRTAERILIP
                     PVYRRILRPVGGYCAYQDSSCQWGVLTVDGRIIIRARYMEVEIDRDGTARLTLVPGKME
                     TVKLTD"
     CDS             6099..6275
                     /locus_tag="ctg20_246"
                     /transl_table=11
                     /translation="MELPDDPMMLFSMVNMKLRDCYHSLDELCDDMNVDKELLVKKLKA
                     AGFEYSKENNKFW"
     CDS             complement(6338..7225)
                     /locus_tag="ctg20_247"
                     /transl_table=11
                     /translation="MLYNTPKPQDTKEGLSDQDFSIYMDAHTVPFSKYPSYLPEGVLGM
                     CTEGNAEIQIGLRKYVICANDILIFMPGFLVSFIKSSLTFTIDYCTFSNALFYDVINGS
                     IKRFPTDFHTYTQTHCIYSLSQEKAEQFSLYFRLLYNRATSPTYLFTKESITNLLKLPF
                     LELYADYYSTVKEHKVTTLHKEEIGYFFLDLLLKHYKENKEVAFYAEKLHVSSKYLTEA
                     LTLVSGKSPKEWIIHYTLQEIYALLENPSISIQEIVQRTRFANLATLRRFFKRHTGTSL
                     LQYRKQDLYKNNQQ"
     CDS             complement(7481..8566)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 57.3; E-value:
                     3.6e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_248"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-17, bitscore:
                     57.3, seeds: 145, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding_C (E-value: 2.7e-07, bitscore:
                     25.5, seeds: 272, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKFCTNRNKQTILIESIPYSNWEIEMVRMNIPADNRSFRQELFS
                     FLSEWFDPADTLLVHTSGSTGKPKELYVEKERMMESACLTCSFLGLQKEDSALLCMPLQ
                     YIAGKMVVVRALVAGLDLLPVTPSGHPLKDLTKAPVFAAMIPMQVYNSLQVPEERAILQ
                     QIRHLIIGGGPIDSQLNAALKDFPHAVWSTYGMTETLSHIALRRLNGPEASDWYTPFES
                     IQIRLSKENTLVIYAPEICGKELVTNDIAEINGQNQFRILGRKDNTINTGGVKVQIEQV
                     EAALKEHLSVPFLITSAPDEKFGEIIVLLAEGQLPDDIEQTCTHQLPPYWRPKRFVPVF
                     KLPLTETGKPDRAIAKLLAQK"
     CDS             complement(8563..9618)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_249"
                     /sec_met_domain="MR_MLE_C (E-value: 1.7e-28, bitscore:
                     93.7, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQTQIIKKQLHFKQPAGTSRGVYTTRDVWYILLTDTGSRHYGVG
                     ECAPLPALSCDDIPSYDEVLATACKNLEKNGEIDREALLPYPSILFGMETALLHFRARS
                     LQFWHTPFSKGKEGIPINGLIWMGNFDEMYRRIGEKMQQGFRCIKLKIGAIDFEKELEL
                     LAHIRRHFTPTQIELRVDANGAFSPTDALEKLHRLSEFQLHSIEQPIRAGQWDEMARLC
                     AATPFPIALDEELIGINRRDRKIELLETIRPQYIILKPSLHGGISGSEEWMELAAERGI
                     GSWVTSALESNIGLNAIAQWCATLQPALPQGLGTGLLFTDNIDYPLHIEGDCLWFHPEE
                     QEPDLLNWLKQ"
     CDS             complement(9597..9980)
                     /locus_tag="ctg20_250"
                     /transl_table=11
                     /translation="MDIEEFRKYCLSLGDVSEKMPFGKFAARYDSILAFYVYGHMFCFI
                     DIDNFTFVNVKSTSDEIEYIKERHVSVGNPINQSLKHWLQLNFDGDIPDTSIYTWVQRA
                     FEIVRDKYTKPTTHKKKCSKPKL"
     CDS             complement(10001..10822)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_251"
                     /sec_met_domain="ECH_1 (E-value: 1.6e-84, bitscore: 277.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METRKWKTIKEYQDILFDFYNGIAKITINRPRYRNAFTPTTTSEI
                     SDALYYCRECQDINVVVLTGAGDKAFCSGGDMHVKGHGGYIGTDGVPRLNVLDVQKQIR
                     SLPKPVIAMVNGYAIGGGHVLHVVCDLTIASENAIFGQTGPKVGSFDAGFGSSYLARIV
                     GQKKAREIWFLCRQYSAQEALEMGLVNTVVPFDRLEDETVAWAEKMMEHSPLALRMIKA
                     GLNAELDGQAGIQELAGDATMLYYMTEEAQEGGKAFLEKRKPRFQDYPKFP"
     CDS             complement(10822..12495)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_252"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.8e-06, bitscore:
                     21.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLKAHGVRKIVLCPGSRNAAIVHTLANIEDFT
                     CYSVTDERSAGFFAIGLSLQGGGPAAVCCTSGSALLNLHPAVAEAFYQQVPLIVISADR
                     PAAWIGQMDGQTLPQPHVFGTLVKMSVNLPEVHTEEDEWFCNRLINEAILETTHHGKGP
                     VHINVPISEPIYRFTAKTLPEARVITRYQGLSVYDRDYKELIERLNKYNKRMVVVGQMN
                     LIYLFEKKYVKPLYKHFAWLTEHLGNQTIPGIPIKNFDAAVYSMTPERQEDMAPEILIT
                     YGGHIVSKQLKKYLRNHPPREHWHVAADGKIADLYGCLTTVIEMDPFEFLEKIAFLLDN
                     KPTHYPLMWENYCKTIPMPDLAYSEISVIGKLIQALPEPCALHLANSSTVRYAQLFTVP
                     PRVEICCNRGVNGIEGSLSTAIGYAAASSKLNFIIIGDLSFFYDMNALWNQNYGANIRI
                     LLLNNEGGEIFHTLPGMDKSSRSREFITAEHYTTAKGWAEERGFIYMKVTGEEELEEAM
                     QPFTSPETRMQPMLLEVFTDKEKDTTLLREYYHGLKNKNE"
     CDS             complement(12495..13664)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_253"
                     /sec_met_domain="Chorismate_bind (E-value: 3.9e-56,
                     bitscore: 184.4, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPDIHTQKLLDCLTHSHLGFALYRLPWTDECYLVLQTSGDVEQ
                     LADIQELNEKKGFVMAPFRISEEHPLVLIRPDVTAYDWNEISEALSSLECVDTLLTCKS
                     RQNELSPFVSEETDKEQYTRAFGRFITPLQEKQFQKLVLSRSSARHIGDDFSPLGAFVR
                     ACNNYPRMMIYLCHTPASGTWLGSTPEILLSGQGKEWHTVALAGTMPMQDEVMPTNWDK
                     KNQEEQGYVADYIRRIAKKFGNKMTEKGPYTARAGQLVHLKTDFYFLLKNTDHIGDLLQ
                     ELHPTPAVCGLPKEEAFRFILNNEGYDRSYYSGFTGWLDTEGHTDIYVNLRCMEIKPGE
                     AILYAGGGILASSEVESEWVETGDKMNTMRSILHPDFISKQMETIKVEE"
     CDS             complement(13661..14068)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_254"
                     /sec_met_domain="HBT (E-value: 1.9e-13, bitscore: 44.6,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEEITCKPDYSNSMAEHLGIRFLPPTENAVHAEMPVDHRTSQPF
                     GMLNGGASLALAEIVAGHGSMSLCREGEYACGVQVSGNHLSAVPVGGKVFATGKLIHRG
                     RSSHIWNIDITTPQGELVSTVRVVNFILKKK"
ORIGIN
        1 cagtgaagaa ggagaatact ttacttttct tgcggattgc acgtaggtaa cgtgtaaggc
       61 tgaaggttag taacgtatgg ggttacatgt tagtaacatg ctaggccgaa ggttagtaac
      121 gtatcggctc cctcattgtt gacattgcaa agataggtac tgtgaaatgc gtgctgacgc
      181 tttatgacac cttgtggcac tttatggctt tcatcctgtt ccagagagct tgcagggcta
      241 tccggggctg cccagatgcc ggttgatcag tgtcacctgg cggctcgtga agactttttg
      301 cgaggtatag taacccgttg cggataactc ttccatcaga gggggacagc cgtttatcca
      361 cctcatcaga tgccgggtgg ctatccgggg atttgaaccg ggaaaataga gcagagccag
      421 gctacccttt gtcatggatg ggaaataaag gaaatctttc atatttatac attttaaatt
      481 caggaatctt gcaaacttgc agaacttgca ctctctctca cacccacaca cgtacgtgtg
      541 tgcatgcgcg cgttgaattc gtattcgcca cgccccactt tgaccagctg tccgcgttcg
      601 gtcatacgtt tcagcagcga gtccaccgag cctgccggaa ctcctacctg ttctcctttg
      661 tcgatggctt cgttgcgggt gaagcgcagg ggaaggcagt cgaacagggt ttcgggagtc
      721 atgttcgccg atggtgcggt gggggttcct gcgggcagga gcgagagaat gtggcatgca
      781 tggcggtaca gaggttccac caaggccagc acggcataaa agtcgtcggt gcggatggag
      841 aggttgaatt gcggcacgat tccgtctgct atgttttctt gtggaatatg ggccgacggg
      901 gtcagtccgg gacagttcag cagggtacgc acgatgtttt cctgtggttc gccgctcctt
      961 tcgcctcccg gcagcaggga ttccagagag cgcagcaggg cgataatgct tatgatgcgg
     1021 aagatattga tggcaatacg ggttacagcg cttttcatct ggttaccgtg aatggcggag
     1081 gctcgtccga atacacgggc aaagtggaag ttgaatatct ctttttgctc gtgggtgagc
     1141 ttcatgttga tgttgctcac cgaggcggtg atggcgttca gcacttcttt ccattgtgcc
     1201 ccccattcca gaaaacggga gtcatagtct gtatccgctt cgttgaactg gtcttcccat
     1261 tcttcaatgg caggcatata gtagaacagc tggcgcgaga acaatccgtt ttcggccgat
     1321 gggataaggg gcttgatttg tgcaggcgtg ccgctgagaa gcacgcagag gaacgtgacg
     1381 ttacattcgc ggtattcgtg attggtgcgc cggttgtagg ccagccggtc atggtcgaaa
     1441 catttccgga ggaggtcgct ccagtgtccg tgatcgcctc caatggcggt gctcacggtg
     1501 tcggcctcgg tttcgcatat cagtcctacg cctccggagt ccatcaggtt ttcctgtatg
     1561 cctgtaccgg tattgtcacc ggctatgagg agcattttca gctggggctg ttcgggttca
     1621 ggggtattta ccttttcctt ccccaaagta tcccattttg tcttttccat gcggtaggtc
     1681 tttatttttt cccggtaggt gtccagcagc gcgttgtgta tgggttctgc cagacggcgt
     1741 acccaggtca gtgcaccctt gccggaagcg ggaggcgcgg tgacgaacac ttgcagacag
     1801 ggatacttgt gttttcgtcc gtacacaaaa cttaccagtt tgttgagggt gcttcccagc
     1861 acggttgctg cacccagcag caggatatcc cgttgggcgg gagagttacc gcagtctatg
     1921 atcccttgca ggaaggcggg ccagcggtag tcggggaaag agggaagtcg ggcagggagg
     1981 atggctttgg gcacaccgtc ggacaggggg gaggctgtgt ccgtgaaaac agcgtcgggc
     2041 ggagtcccgt cggaggcatc cggatgggca ttatacgata cgcgtgcacg tgtgtgggtg
     2101 tggagagact gcaagttctg caagtttgca agtttcgggt ccattttcac cccggccacc
     2161 tctgccagat ggaagacggt tcccagggaa tttctgcctg ttcctttggt cagagcatgt
     2221 ccgtacagtt tgtctgcttc atcgtggtgg tacttttcgg atatgcggca gatgcggtgg
     2281 aaccgggtgc gtccttcctc gccgcaagtg ttggctatgg caaaggccag cggcatatat
     2341 tcctgatagg tgggggccac attgactccc gcttgttcga tggctgttac cagctgttcc
     2401 aagatagaaa tagaatcgtt cattttttaa tatttatggt tattgatttt cgcttctccg
     2461 tcgtgcgaca gaaaacaggc tctggacaag tcggcattgg ccctgtccac tttcagctcg
     2521 tatttccatt ccagatactc ccatgcggtg tgcagggcat tgtcgaagga ttcttctacg
     2581 ctcaggaaag ggtttatgcg ataagggata aaaagtttta ctccctgatt tccggggctg
     2641 acaaaggaaa gtacggggtg cagcacttca tcggcaaaga gacggtcgcg ccacattgcc
     2701 gcttcttcgg tggaagccag ttcgtcaata tctatgacaa agagacccga aggaacttgc
     2761 atgcattgtt ctttgcagta agagaagata cctgccggag tgacatacgg taaaagggtc
     2821 tgtttattct ttcggaacgc ttgcttgtct ccgagtccgg ctctgacttt atgcgtcagt
     2881 tcttccagtt gcggattggt gctgatgtag gtatgaagcc ctgccacact gcatatacat
     2941 gtgggtattt tattggtgac gggtgcattg aaaaatgaca tgatgtattc tttcataaaa
     3001 gaaattgatt ttgatttatc tgcacaaata tacgggtagg gaatgacgta tggaaatcga
     3061 ttcataaccg tttactatct gtttactatt ggtgcatgct attgattata tattgatgaa
     3121 atatggattt tgattaacga tctgttgata ataattaaag aatagagaaa agaaatagta
     3181 tatgaatgaa aaacctgata tgatgataaa tatttatggc ggaaacaatc tgattgcccc
     3241 tgtggcgtct tccgccattc agaactttta tggcgaccgg ggtgatgagg ccgccgacca
     3301 accggaagat tctgagaaaa cggagagtac agaaagtgtg acggatgaga agccggcaca
     3361 ggagccggcg gaactgtcgg atgatgaatt ttacgtatcg gtctatatac ccgatataaa
     3421 ggtgatgagg gcttacaaga tacttttggg agagtgtacc acggcacgcg aactggcggt
     3481 ggtggtagga aagatgctgg ccgatgagaa ctgtaggaat gtagacaaac acacggtggt
     3541 gaaagcggct ttcatcaagt cgttgctacc ttttgccaaa cggcttgtgt cgggcggtac
     3601 gatagccaat atacgggcgc agattaataa tatgctggct agtaaataat tttttcagtt
     3661 atcctcttac tccattggca cgttagcaaa tcggcaaatt atttatgttg cgggattatc
     3721 agatagagat gaaaacacgt ctgatggaag cgtggaaagc tcaccggagt gtgatggtgc
     3781 agatgcctac cggtacgggc aagacacatt tgctggcatc tgtggtcagt gagttcgtgt
     3841 cttctgccgg cagcgggata tggcttattg cccatcgtag ggaactggtg gcgcaaatgg
     3901 aggaaacgct ggctaaatat ggtatccgga gggaggatac tccggtcagg gtgatgtctg
     3961 tccaatggct gtcccggcac tggaatgagg cgggtgatgc tccgggactg attgtgatag
     4021 acgaggctca tcatgccttg tccgcttctt acacggagat gtggaagcgt tatcctgccg
     4081 caaagaaact gggtgtgact gccacacctt gccgcctgaa ccgtaggggg ttcacggaac
     4141 tgttcgaggt actggttact tcgtggagta ttgccgagtt tattgaaaaa ggcgtgttgt
     4201 ctgtgttcga ttatgtatcc atccgtcccg gcagcgagga gcagcggctc attgacggtc
     4261 tggagaaacg gggggccgat ggggattatc aggtgaaaga gatggatgcg gtactgaaca
     4321 ggcgtcccgg tatcgagcgc ctgtaccgca gtgtcaggca gtttgcttcc ggcaagaagg
     4381 ggatggtgta tgccatcagc attgaacatg cccggcggat agcggagtat tacagcaggc
     4441 ggggagtgaa tgcggtggct gtggacagca agactcctgc tatggaacgc aagcggatgg
     4501 tggaggagtt cagacatgga aaaatcgagg tgctggtgaa tgtggatgta tttagcgagg
     4561 ggttcgactg tcccgatgtg gagtttgtac aactggcccg tcctactttg tcactggcta
     4621 aatatttgca gcaggtagga cgcggattgc ggagatcgga gggcaaggag gcgtgtatgc
     4681 tgatagacaa tgtggggctg taccgcattt tcgggcttcc tacacagcga tggaactggg
     4741 atgctatgtt ccggggacgg atggcgggaa aggggagttt gcccggacgg atgaattgtg
     4801 atgcttccgt tactgctttt ccggtggtgg aaaggccggc tgaagccggt ggggacttgg
     4861 tgatggttat ggagcacggg cgtttgcttt cttccatcag agagcaggct ttgccggatg
     4921 agaaggagca gtcaccgtca tgcaggttga gggcatttgt agataaggaa acaggtcttt
     4981 ggggattgga aaagggagat gagatgctgc cggacgtttc gtttaaagag attttgagta
     5041 tcaaaggacg ttttgccgtg gggaggcttc ggaacgggtg tgtccgggta ctggatgata
     5101 cgggggcttt ggtggccgaa ctggggcatt gccgtgaggt gaggttgctg aaagatgatt
     5161 tgttgcaagt ccgtcatgcc gggaattcgg tgtcttatgt ggatttacgg aacggccggt
     5221 gttatgctgt ccgcccgcgt gtcctcagat acgggagcat agaattgtta caggtgaacc
     5281 gtacttatta cagcaggaca aggcaggtgt atgccaatac atgcgggttg ccttcttcgt
     5341 ccattgtgtg gatggggttt tatgtgaaga tgtacgatgg cagagtgcct tcccgatgcc
     5401 gccgcatgga agatggaggc ttttgttgtg aaccgcaggt ttgtctgttg gagggggatg
     5461 aggagcgtgc ttattacctg agcggacggt tgccggatca aagtattgtg gtgatggatg
     5521 aggagggacg gtattatcat gtggagaaag gacatggaaa gcgttatgtg gcttgtaacc
     5581 gtccgtcgga ccggagtgag gattttgatg aggcggtggc attgctccga aggcaggcgg
     5641 acgagcgtgt ggagaaacat ttgcaggagg aaaagtgcga gactgaacgg aaacggcagc
     5701 gtataatcag caggagtgtg gaggccgtac cttttcagat aggagtgaaa tgggggctga
     5761 ggacagcgga gcggattttg attccacctg tctatcggag aatattgcgt ccggtgggtg
     5821 gttattgcgc ctatcaggac agctcctgcc agtggggggt gctgactgta gacggaagga
     5881 tcattatccg ggcccggtat atggaggtgg agatagacag ggatggaacg gcgcgtctta
     5941 ctttggttcc ggggaagatg gaaacggtga agctgacgga ttaataggat aaaaagcagg
     6001 ggataacttt ttgtcagacc gatatttagc gatggaatac ggatcattat gaaaagtttt
     6061 gtaactttgc atccgatttt aaaaaaggag atattgatat ggaattacct gatgacccga
     6121 tgatgctttt cagcatggtg aatatgaaac ttcgtgactg ctatcattcg ctggacgagc
     6181 tttgtgatga tatgaatgta gacaaggagc tgttggtgaa aaaattgaag gcggccggat
     6241 ttgagtatag taaggaaaac aacaagtttt ggtagataga gggatcagcc cgttccggaa
     6301 gaatgcttgg gacgggctga tttttttatt gagataccta ttgttgatta tttttgtata
     6361 agtcctgttt ccggtattgc aacagggatg ttccggtatg ccgcttgaag aaacgtctta
     6421 aggtggcaag attggcaaac cgggttcttt gaacgatttc ctgtatgctg atggatggat
     6481 tctccaataa tgcgtaaatc tcttgcaggg tataatgtat aatccattct ttgggggatt
     6541 ttccacttac cagagtcaag gcttcagtca ggtatttgga ggaaacatgc aacttttcgg
     6601 catagaacgc cacttctttg ttttctttgt aatgctttaa cagcaaatcc agaaaaaagt
     6661 atccgatttc ttctttatgc aaggtggtga ctttatgttc ttttactgtg ctgtaatagt
     6721 ctgcataaag ttccagaaaa ggtaatttca gcagattggt aatagattct tttgtaaata
     6781 aataagttgg agaagtagct ctgttgtata gtaaccggaa atagagggag aactgttccg
     6841 ctttctcttg ggatagcgaa tagatgcagt gggtttgggt gtaggtatga aaatcggtcg
     6901 gaaaacgttt gatacttcca ttgatcacgt cataaaaaag ggcatttgaa aaagtacaat
     6961 aatcgatggt gaaagtcaga ctggatttta taaatgaaac caagaatccc ggcatgaaaa
     7021 taagaatgtc gtttgcacaa ataacatatt tccggagacc aatctggatc tcggcattcc
     7081 cttcagtaca catacccaaa actccttccg gcagataaga ggggtatttg ctgaaaggca
     7141 ctgtgtgcgc atccatataa atactgaaat cttgatcgga cagtccttct ttggtatcct
     7201 gtggttttgg ggtattatat aacatacttt gtatcagctc taggttcaca aaattagaat
     7261 ttaatgatac attccgccgg aagtagtgga cataagggaa aataaaacgg aaaaaaacta
     7321 cgtgtatttg atttttttaa tataatgata ggagaacaat tttagcttcc cgtaagttgt
     7381 aggagaacac ggaaaattat tcttttttac agaaagaagg gtgaattcaa aaagatcgtt
     7441 tgatttgttt ttgaattcac cctttatgaa tggagcggag ttatttttgc gccagtaatt
     7501 tggctatggc acggtcgggt ttcccggttt ctgtcagggg aagtttgaat accggaacaa
     7561 aacgtttggg acgccagtag ggaggtaatt gatgtgtgca ggtctgttct atgtcgtcgg
     7621 gcagttgccc ttcggcaagc agcacaatga tttctccgaa tttttcgtcg ggagcggagg
     7681 tgatcaagaa aggaacggac aggtgttctt tcaatgcggc ctctacttgt tctatctgca
     7741 ctttcactcc tccggtattg atcgtattgt cttttctgcc tagaatgcgg aattggttct
     7801 gtccgtttat ctcggctatg tcattggtca ccagttcttt tccgcaaatt tcgggagcgt
     7861 atatcaccaa ggtgttttct ttactcagac ggatctgtat gctctcgaaa ggggtgtacc
     7921 agtctgaagc ttcaggaccg ttcagtctgc gtagggcaat gtgtgataag gtttcggtca
     7981 tgccgtaagt agaccatacg gcatggggga aatcttttaa cgcagcattc aattgggagt
     8041 cgataggacc acctccgata ataaggtgcc tgatttgttg caatatcgct ctctcttcgg
     8101 gaacttgcag tgagttatag acttgcatgg ggatcatggc ggcaaagacg ggggcttttg
     8161 tcaggtcttt taaaggatgc ccggatggag tgacaggcag caagtccagt cccgctacta
     8221 aggcacgtac taccaccatt tttccggcaa tgtattgcaa gggcatacag agcagggcgg
     8281 aatcttcttt ttgtagtccg aggaaggaac aggtgaggca ggcgctttcc atcatgcgtt
     8341 ctttttctac atacagttcc ttgggtttgc cagtggagcc tgaagtatgt accagcaggg
     8401 tgtctgccgg gtcaaaccat tcggaaagaa aggagaaaag ttcctgccgg aaacttcggt
     8461 tgtcggcagg gatattcatt cttaccattt caatttccca attggagtag gggatgcttt
     8521 ctatcagaat ggtttgtttg tttctattgg tgcagaattt tgtcattgtt tcagccagtt
     8581 tagtaaatcg ggttcttgtt cttcggggtg gaaccaaagg cagtcccctt cgatgtgaag
     8641 cggatagtct atattgtcgg taaacagcaa gccggtacct agtccttggg ggagggcggg
     8701 ctgcaaagtg gcacaccatt gtgcgatggc attcagtccg atattggact ccagagcgga
     8761 agtgacccat gagccgatgc ctctttcagc cgccagttcc atccattctt cggagccgct
     8821 gattcctccg tgcagagaag gtttcaggat aatgtactga ggacggatgg tttccagcaa
     8881 ttctattttc cggtcgcgcc ggttgatgcc tatcagctct tcatccagtg caatgggaaa
     8941 gggggtggcg gcacagagtc gggccatttc atcccattgt cccgcacgga tgggctgttc
     9001 gatggaatgg agctggaatt cggaaagacg atgtaacttt tcgagggcat cggtaggaga
     9061 gaaagcaccg ttggcatcta cacgcagttc gatttgggtt ggggtgaaat gccggcggat
     9121 gtgcgccagc agctccagtt ccttttcaaa gtcgatagcg cctattttga gtttgatgca
     9181 gcggaaacct tgctgcatct tttccccgat gcgccggtac atctcgtcaa agtttcccat
     9241 ccagatgagt ccgttgatgg ggataccctc tttgcctttg ctgaacgggg tgtgccagaa
     9301 ttgcaggctg cgtgcccgga aatgcagcag ggcggtttcc ataccgaaca ggatggacgg
     9361 atagggaagc aaggcttccc ggtctatttc cccgttcttt tccaggttct tgcaggcagt
     9421 ggccaacacc tcgtcgtatg aggggatatc atcacagctc agggcaggga gaggggcgca
     9481 ttcacccacg ccatagtggc ggctgccggt gtcggtgagg aggatgtacc atacatcccg
     9541 ggtagtatat actcctctgg aagtaccggc aggttgcttg aagtgtaatt gtttttttat
     9601 aatttgggtt tggaacattt ttttttatgt gtagttggtt tggtatattt atccctgaca
     9661 atctcaaagg cgcgttggac ccatgtgtat atgctcgtgt cgggaatatc accatcaaaa
     9721 ttaagttgaa gccaatgttt cagactttgg ttgatgggat tgccgactga aacatgtctc
     9781 tcttttatat actcaatttc gtccgaagta gatttgacat tgacaaaagt gaaattgtca
     9841 atgtctataa aacagaacat gtgtccataa acataaaagg caaggatgga atcatatctt
     9901 gcagcaaatt tgccaaatgg catcttttcg gaaacgtcac ctaacgaaag acaatatttt
     9961 ctgaattctt caatgtccat gctttgaatt tgtagtttgt ttatgggaac ttcggataat
    10021 cctggaaccg tggcttgcgt ttttccaaaa atgccttccc tccttcctgc gcttcctctg
    10081 tcatgtaata cagcatggtg gcatctccgg caagttcttg tatgccggct tgtccgtcca
    10141 gttcggcatt cagtccggct ttgatcatac gaagagcgag cgggctgtgc tccatcatct
    10201 tttctgccca tgccacggtt tcgtcttcca ggcggtcgaa aggaacgact gtattgacta
    10261 atcccatttc cagtgcttcc tgtgcggagt attgacggca aaggaaccat atttcacggg
    10321 ctttcttctg ccctacgatg cgtgccagat aggaagagcc gaatccggcg tcgaagctgc
    10381 ctaccttggg acctgtctgt ccgaaaatgg cattttctga ggcaatggtc agatcgcata
    10441 ccacatgcag cacatggccg ccgccgatgg cgtaaccgtt taccatggcg atgaccggtt
    10501 ttggcagtga ccggatttgc ttttgtacgt ccagcacatt cagacgggga actccatctg
    10561 tgccgatata accgccatga ccttttacgt gcatatctcc cccgctgcag aaggctttgt
    10621 cacctgctcc ggtcagaacc actacattga tatcctggca ctcgcggcag taatacaggg
    10681 cgtcgctgat ttccgaagta gtggtggggg tgaacgcgtt gcggtaacgc ggacggttga
    10741 tggtgatttt cgctattccg ttgtaaaagt caaacagaat atcttgatat tctttgatgg
    10801 ttttccattt tcttgtttcc attattcatt tttattttta agtccgtgat aatattctct
    10861 taatagggtg gtgtcttttt ccttgtcggt aaacacctcc agcagcatgg gttgcatcct
    10921 tgtctcgggt gaggtgaatg gctgcatcgc ttcttccagc tcttcttctc cggtcacttt
    10981 catgtaaata aagccacgtt cttccgccca gcctttggcg gtggtgtaat gctcggctgt
    11041 gataaactcc cgggaacggc ttgatttgtc cattccaggc agggtatgga atatttctcc
    11101 tccttcgtta ttcagtaaca ggatgcggat gttggcaccg taattttgat tccacagtgc
    11161 gttcatatca tagaagaagc tcaagtcgcc tatgatgatg aaattcagct tgctggaagc
    11221 ggcggcataa ccgatggcgg tggacaggga gccttctatg ccgttcacgc cccggttgca
    11281 acagatttcc acccggggag gaactgtaaa taactgtgca tagcgcacgg tggagctgtt
    11341 tgccagatgc agggcacagg gttcgggtaa tgcctgaatg agttttccga taacggagat
    11401 ttcggaataa gcaagatccg gcatcggaat ggttttgcaa tagttttccc acatcagcgg
    11461 ataatgggtc ggtttgttgt ccagcaggaa agctattttt tccaagaact caaacggatc
    11521 catctcgatg acggtggtca ggcaaccgta taaatcggct atcttcccgt cggcggcaac
    11581 atgccaatgt tcgcgcgggg gatgattgcg caggtatttc ttcaattgct tggatacgat
    11641 atgtccgccg taggtaatca gtatttcggg ggccatgtct tcctggcgct ccggcgtcat
    11701 ggaataaacg gcggcgtcga aattcttgat aggaatgccg gggatggtct ggttgcccag
    11761 atgttccgtc aaccaggcga aatgtttata aagcggtttc acatattttt tctcgaacag
    11821 gtaaatcaga ttcatctggc ctaccacgac catgcgcttg ttgtacttgt tcagccgttc
    11881 gatcagttcc ttatagtcac ggtcgtacac gctcagtccc tgataacggg tgatgacacg
    11941 tgcctcggga agtgttttgg cggtgaagcg gtagatgggt tcggaaatgg gtacattgat
    12001 atgtacgggt cctttgccgt ggtgggtggt ttccagtatg gcttcgttga tgaggcggtt
    12061 gcaaaaccat tcgtcttcct ctgtatgtac ttcgggcagg ttgacagaca tcttgactaa
    12121 cgttccgaac acatggggct ggggcagggt ttgtccgtcc atttgtccta tccaggcggc
    12181 ggggcggtcg gcagaaatga caatcagagg tacttgttgg taaaaagctt cggctacggc
    12241 agggtgcagg ttcagcaggg ccgaaccgga ggtgcagcat actgcggcag gacctccccc
    12301 ttgtaaagat aggccgatag caaaaaaacc ggcactgcgt tcatcggtta cagaataaca
    12361 agtgaagtcc tctatattgg ccagagtgtg tacgatggca gcattacggc tgccgggaca
    12421 aagcactatt ttccgcacac cgtgcgcttt gagaagtgcc accaactgaa gtatgttctt
    12481 tttgtctgaa tacattattc ttctacttta attgtttcca tttgtttact tataaagtca
    12541 ggatgaagga tgctccgcat cgtattcatc ttgtctcccg tttccaccca ttccgattct
    12601 acttccgagg aagccagtat tcctcctcct gcatacagga tggcttcacc cggctttatt
    12661 tccatgcagc gcagattgac gtagatatcg gtatgtccct ctgtgtccag ccatccggtg
    12721 aatccggaat aataactgcg gtcgtaccct tcgttgttca gaataaaccg gaaagcctcc
    12781 tctttgggca ggccgcagac ggcgggagtg ggatggagtt cttgcaataa atcgcctata
    12841 tggtctgtat ttttcaacaa gaaataaaaa tcagtcttga ggtgtaccaa ttgtccggca
    12901 cgggcggtat agggaccttt ctccgtcatc ttgttgccga attttttggc gatccggcgg
    12961 atataatcag ccacatagcc ctgttcttct tggttcttct tgtcccagtt tgtcggcatc
    13021 acttcgtcct gcatcggcat tgtaccagcc agggccacgg tgtgccattc tttgccttgt
    13081 ccgcttaata agatttccgg tgtgctgccc agccaggttc cggaagcggg ggtgtggcat
    13141 aggtaaatca tcatgcgcgg ataattgtta caggcccgga caaaagcgcc aagtggtgaa
    13201 aaatcatctc cgatatgtct ggcggaagaa cgtgacagaa ccaatttttg aaactgcttc
    13261 tcttgtaagg gagtgatgaa acgcccgaat gcgcgggtat attgttcttt atccgtttct
    13321 tcggaaacaa aaggagagag ttcattctgc cggcttttgc aggtgagcag ggtatccaca
    13381 cattccagtg aagacagtgc ttcgctgatt tcgttccagt cgtatgccgt gacatccgga
    13441 cggataagta ccaagggatg ttcctccgat atccggaaag gagccatgac aaatcccttt
    13501 ttttcattca gttcttgaat gtccgctaat tgttccacat cgcccgaggt ttgcaatacc
    13561 aggtagcatt cgtctgtcca aggtaaccgg tagagggcga aaccgaggtg gctatgtgtc
    13621 aggcaatcca ataatttttg cgtatgtata tctggtagat tcatttcttt ttcagtatga
    13681 aattaacgac acgaacagta gaaaccagtt ctccctgtgg agtggtgata tctatattcc
    13741 atatatgcga ggatctgccg cggtgaatca gtttgccggt ggcgaatact ttgcctccga
    13801 cgggcacggc cgacagatga tttccactta cttgtactcc gcaggcatat tcgccttccc
    13861 ggcatagcga catggagcca tgtcctgcca caatctcggc cagagccagt gacgcgccgc
    13921 cgttcaacat accaaagggt tgtgaagtac gatggtctac aggcatttcg gcatgtaccg
    13981 cattctcggt ggggggtaga aaccggatac ccagatgttc cgccatcgaa ttcgaataat
    14041 caggtttgca ggttatttct tccatcattt gtatgtctgt tcttttctat agggctacaa
    14101 atatacataa atttcgtaca ggaaaccatt cattgtattg gtgtaagaat atgctttgca
    14161 gagtagcgg
//
