LOCUS       c00063_gnlPro..        14871 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KJIABEKM_63.
ACCESSION   c00063_gnlPro..
VERSION     c00063_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 20:30:00
            Original ID  :: gnl|Prokka|KJIABEKM_63
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 83267
            Orig. end    :: 98138
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14871
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[93267:98136]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14869
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14871
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14871
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="2"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(106..3399)
                     /locus_tag="ctg63_84"
                     /transl_table=11
                     /translation="MRISLALLFAVVLQLSAEDGYAQRTRVAISMNNVSVEQVLNKIEE
                     TSDYVFLYNDKTIQKNRIVSVRNNSGKILDILDEVFKGTNITYTVVDKQIILSTNKLNV
                     TEQDPTIQVKGTVKDTKGEPLIGVNVKVKGTTTGAITDFDGNFQIQAKKGAVLEISYIG
                     YASQEVKVTDNKSLSIVMTEDAKVLNEVVVTALGIKRETKSLTYNVQQIGGDEVAKAKD
                     MNVMSSLAGKVAGVNINASSSGIGGGARVVMRGTKSISGNNNALYVVDGVPLANISGEQ
                     PDDQYTGAGQSGDGLANFNADDIESISVLSGSAAAALYGSAAANGVVLITTKKGAVDKT
                     RLTYSNNSTFYSPFRLPEFQNTYGSETGEWYSWASKLSSPTDYEVKDFFQTGYNVANTV
                     SLTTGTQKNQTYVSVGAVNARGIIQNNDLDRYNFSVRNTTSMLNDKLTMDLSFMYSNVK
                     EQNMLSQGEYANPLVPVYLFPRGDDFSKYQYYERYDVDRNIKTQFWPLKENGLSMQNPY
                     WITNRNMYTNKKDRFLASGSLKYTITDWLNVSGRVKLDKETINSEKKMYASTLNVIAEN
                     SDKGAYVQSNKNTSQIYADAMLNINKYFYHDTWNLTASLGASLLDLDYKELNFGGGLLT
                     IPNLFTSNNANVSGKLTYKNTNYHDRTNSLFGTFSLGYKGMVYVDGSLRNDWISALAGT
                     NHSSILYPSIGASAILTNMFTMKSNILSYAKVRLSYSEVGNAPERFRAITTYAVLGGLN
                     TTSYFPIKDLKPERTHSWEGGFNLGLFDNKLTLDVTAYKTYTENQLFSPEISTTTGYSK
                     LYVNAGKVTNKGIELALGFKQNIGPVDWKTTLLWSLNRNRIDQLLPEYTNEELGVTVHL
                     DEMDVYSLGGAKQRLTVGGSMGDVYVNTMRTDEHGHIWMNSMTGTLETDKNNYVYAGNT
                     NPKYTLSWRNEFNWKGISLGFMLNARVGGIGVSATQAVMDYYGVSKTSAEARDNGGVKV
                     NGQMIDAQTWYQTIGANGTGYVGSMYVYSMTNVRLGELTLGYDIPINKWCKWISGLNVS
                     FVGRNLWMLYCKAPFDPESTASTGTYNQGMDYFMQPSLRSMGFSAKISF"
     CDS             3500..3670
                     /locus_tag="ctg63_85"
                     /transl_table=11
                     /translation="MNYGLIPASVCETLYRESGKFGGRQLLVAAFFLSFILLCYSMGFY
                     FKGYYSNINLL"
     CDS             complement(3651..4583)
                     /locus_tag="ctg63_86"
                     /transl_table=11
                     /translation="LKENMENMSPESLLRKAQALGDDIKEMESIDVLGAYYQAQTTIKT
                     NRRKNMYNQLMRYAAFLTIPLFLSSLVLGYLYFSGTETDEKYAEVVTATGSVIRYELPD
                     HSVVWLNAGSTLRYPTTFKKDNRLVELKGEAYFEVQADKDRPFYVNTPNGLSVYVYGTK
                     FNVAAYEDDNYIETVLEKGKVNVITPDQETIVLAPGEQLLYDKQSQKSKKNKVDVYGKI
                     AWKDGKLIFRNASLEEILKRLERHFNVEIQFNNRSGKEYKYRATFRTETLSQILDYLAR
                     SADLKWKIEEPQQQADDTLSKTKIRVDLY"
     CDS             complement(4666..6657)
                     /locus_tag="ctg63_87"
                     /transl_table=11
                     /translation="MKNKFFLLAITFCLPIHSQGVSKSFIPMAEIPAGSFYMGSDGLGE
                     DFDEAPIHQVIISRPFRMGITEITNAQYESFRPEHRALRGKNGVSLEDDEAVVNVSYSD
                     AVAFCEWLSRKEGKNYRLPTEAEWEYACRAGTYTLFSTGDGLPAVYHRNQKVVRDFDPV
                     SLKVAQTPPNTFGLYDMHGNVEEWCLDWYAPYSAEKQKDPAGPLTGEFRVTRGGSHHTP
                     EKYLRSANRLAMLPEDKHSQTGFRIVEADTRLNVSGTSAPVPFNQKSVENTSIKWKKVS
                     AITPMFLPPIPFVVRPVCDSNTPFYLHNHQPAVTWCDNGDLLAIWFSANEENGRGMVVL
                     GSRLRAGHTDWDVASLFFKVPDRNMTGSALLNDGKGKLYHINGVEASGDWQNLAMVLRT
                     STDNGASWSTPKLIAPEHTKRHQVIAGTIRTREGWLVQACDAGPGSHDGAAVQISKDGG
                     KTWCDPWDGAPLPDFKEGGTGSTIAGIHAGIVQLGNGSLMAMGRGNSIRNKEGKLRMPM
                     SISDDMGKTWKYVASELPPIDGGQRLVLMRLNEGPLLLVSFTDHPQRTPLEERGLEFKD
                     KNGNVKKGYGMYAALSYDEGKTWPVRKLLTDGEYRFLNGGAWTGYFEMDENHAEPRGYL
                     AGTQTPDNVVHILSSRLHYRFNLAWLEK"
     CDS             6831..7394
                     /locus_tag="ctg63_88"
                     /transl_table=11
                     /translation="MKISFSKQTKERAFKQLYEEYYAPFCLYAKRFVDDKETREDIVSD
                     VFTSLWDKLDTDSFDLQSNTALAYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPVYET
                     EPDSIYTLDELYRMLYETLNKLPENYRTVFIKSFFEGKTHTEIAEEMNLSVKSINRYKQ
                     KTMELLRNELKEYMPLLLLLFLRA"
     CDS             complement(7767..8882)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 53.2; E-value: 6e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_89"
                     /sec_met_domain="AMP-binding (E-value: 9e-17, bitscore:
                     53.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFDRQQQRLLLEGKEYTFEDISQLIAGGAEAHSSAYWDLYLFLN
                     EWFNGSPVITVHTSGSTGIPKELMVRKDQMMQSARLTCEFLNLKKGESALLCMNLRYIG
                     AMMVVVRSLVAGLNLIVRPASGHPLADIKEPLRFVAMVPLQVYNTMQVPEEKERLKQTD
                     ILIIGGGAVDEALETEINHLPTAVYSTYGMTETLSHIALRRLNGASASEHYYPFPSVKL
                     SLSAENTLIIDAPLVCDETLQTNDIARIYPDGSFMILGRKDNVINSGGIKIQAEEMEKL
                     LRPFIPVSFVITSVPDQRLGQAVTLLLADQPDTEEIGNKLHEILEPYYRPKHILTIESI
                     PQTENGKINRAECRILAKQMLMTFYPHTLTP"
     CDS             complement(8914..9939)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_90"
                     /sec_met_domain="MR_MLE_C (E-value: 3.2e-29, bitscore:
                     94.6, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCKIDIIPRLLHFKQPAGTSRGIYTTRKVWYLHFTSPDFPGRVG
                     IGECAPLPALSCDDLPDYEDILKRICRQVEKEQGMWDKDVLCQYPSILFGLETAIWHFF
                     AGSWALSDTAFSRGEVGIPINGLIWMGDFDHMLSQIEKKMEAGFRCVKLKIGAIDFEKE
                     LALLRHIRTHFSSKEIELRVDANGAFSPGDAMEKLKRLSEFDLHSIEQPIRAGQWEEMA
                     RLTSESPLPIALDEELIGCNTLEEKKKLLATIRPQYIIIKPSLHGGICGGDEWIMEAEK
                     QHIGWWITSALESNIGLNAIAHWCATFNNPLPQGLGTGMLFTDNIEVPLEIRKDCLWFC
                     K"
     CDS             complement(10001..10825)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_91"
                     /sec_met_domain="ECH_1 (E-value: 8.6e-82, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             complement(10829..12496)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_92"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.3e-07, bitscore:
                     21.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYAVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVVISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINVPISEPLFQFTVDALPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKIDQMVPELLIT
                     YGGHVVSKRLKKFLRQHPPKEHWHVSPDGEVVDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPDYPRVWENYCKIIPEPEFAYSEMLAVGTLLKALPESCALHLANSSVVRYAQLYSIP
                     STIEVCCNRGTSGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNINVRSNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSAKGWAEERGFLYLQAQNDEELTEAM
                     KTFTQPETMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             complement(12516..13631)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_93"
                     /sec_met_domain="Chorismate_bind (E-value: 1.6e-56,
                     bitscore: 184.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVRL
                     IYDLKELNGQRGFVIAPFQVSETCPVVLIQPDQWGQPLPIDNDTAEEREVALRMQGQES
                     FLTSSTEEYASCFHTFINALRDNTFDKLVLSRHLTIDKVSGFSPLSIFRAACRRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     ASYIRRQLLSLGIHSTENGPYPAYAGALSHLKTDFRFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYRFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIKDEQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIATPPLKS"
     CDS             complement(13628..14869)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_94"
                     /sec_met_domain="HBT (E-value: 1.4e-17, bitscore: 56.4,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="RVIMKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLA
                     SGRPTYGLMPLAKMLELGNYGGFILSYNGCQIINAQNGEILFERRINPEMLPYLEKKAR
                     KNGFALFTYHDDTIITDSPENEHIQNEARLNDLQIIKEEEFSAAVDFAPCKCMLVSDDE
                     EALLGLEDHWKRRLNGALDVFRSEPYFLEVVPCAIDKANSLGALLEVLGMKREEVIAVG
                     DGVCDVTMIQLAGLGIAMGHSQDSVKACADYVTASNEEDGVAVAVEKAIISEVRAAEIP
                     LDQLNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALAETVAG
                     LGSMILCQPDEIVVGMQVSGNHISSAHEGDTVRAVGTVVHKGRSSHVWNVDVFTSTNKL
                     VSSIRVVNSVMKKR"
ORIGIN
        1 tcgtacaacc tacatttatc atgattactc caaggagtaa gtagtagttc cttactttaa
       61 aaaacttacg tatgttcatc attatttttt ttaaaggtta tccaattaga aagaaatctt
      121 tgcagaaaat cccatcgatc tcaaactcgg ttgcatgaaa tagtccatac cctggttata
      181 agtacctgta cttgcagtag attccgggtc aaatggagcc ttacaataca gcatccataa
      241 attacgtcct acaaaggaca cattcaatcc agaaatccat ttacaccatt tattgatcgg
      301 aatatcatat cccaatgtca attctcccaa acgaacattc gtcatactat atacatacat
      361 agaacctaca taacctgtac cattagctcc gatagtctga taccatgtct gggcatcaat
      421 catctgaccg tttactttca cgccaccatt atcccgcgct tctgccgatg ttttagacac
      481 tccataatag tccattacag cttgagtggc agaaactccg ataccaccta cacgggcatt
      541 caacataaat ccgagactga ttcctttcca attaaattca tttctccagc taagagtata
      601 tttcggattg gtattaccag catagacata attattctta tctgtttcca atgtacccgt
      661 cattgaattc atccagatat gtccatgctc atcagttctc attgtattca catatacatc
      721 tcccatagag ccccctactg ttagccgttg tttggcaccg cctaatgaat aaacatccat
      781 ttcgtccaga tgtactgtca ctcccaactc ttcatttgta tattcaggga gtaattggtc
      841 aatgcggttt ctgttgagcg accatagtaa agttgttttc caatctacag gccctatatt
      901 ctgtttaaag ccaagagcta actcaatacc tttattcgtt actttacctg catttacata
      961 taatttagaa tatccggttg ttgtagaaat ttccggactg aagagctgat tctccgtata
     1021 tgtcttataa gctgtcacgt ccagtgtcag tttattatca aacagaccta aattaaatcc
     1081 tccttcccat gaatgagttc tctccggttt aaggtctttt atcgggaaat aagaagtggt
     1141 attcaatcct cccaacactg cgtacgtagt gatagctctg aatctttccg gtgcattacc
     1201 cacctcacta tatgaaaggc gaacctttgc ataagaaaga atgttagatt tcattgtaaa
     1261 catattagtc agaattgctg aagcaccgat agaaggatat aatatggaag aatggtttgt
     1321 tcctgccaaa gcagatatcc agtcattacg taacgaacca tctacataaa ccatgccctt
     1381 atatcctaat gagaatgttc cgaataaaga attggtacgg tcgtgatagt tcgtattttt
     1441 ataggttaat ttaccggaaa cattcgcatt gttagaagta aacagattag gaatggtcag
     1501 taatcctcct ccaaaattaa gctccttata atccaaatcc aataaactgg cacctaaaga
     1561 tgctgtcaga ttccatgtgt cgtgatagaa atatttattg atattcaaca tggcatccgc
     1621 atatatctga ctggtattct tgttcgattg cacgtatgct cctttatccg agttttcagc
     1681 aatcacattc aaagtggaag catacatttt cttttccgag ttgatagttt ccttatccag
     1741 tttcacgcgt ccggaaacat tcaaccaatc tgttatcgta tattttagtg aaccgcttgc
     1801 cagaaaacgg tctttcttgt tggtatacat attccggttc gtaatccagt aaggattctg
     1861 catggataat ccattttctt tcaatggcca gaactgtgtt tttatgttac ggtctacatc
     1921 atatcgttca taatactgat atttcgagaa atcatcaccg cgcggaaata aataaacggg
     1981 aaccaatgga ttggcatact ctccttgcga caacatattc tgttccttta cattagaata
     2041 cataaaactt aaatccatcg tcagtttatc attcagcata gaggtcgtgt tacgaacaga
     2101 gaaattatat ctgtccaagt cattattctg aatgataccc cgggcattca cagcacctac
     2161 ggatacatag gtttgatttt tttgtgtccc tgtagtcaga cttacagtgt ttgctacatt
     2221 gtaacctgtc tgaaaaaaat ctttaacttc ataatcggta ggagatgaca atttagatgc
     2281 ccaactatac cactctccag tttccgaacc atacgtattc tggaattccg gcaatcggaa
     2341 tggtgaatag aaagttgaat tattactgta agtcaatctg gttttatcta cagctccttt
     2401 cttcgttgtg ataagtacca caccattggc agcagccgaa ccgtatagtg cagcggcggc
     2461 cgatccgcta agtactgaaa ttgattctat atcatcagcg ttgaagttag ccaatccgtc
     2521 accggattgt ccggcacccg tatactgatc gtcgggttgt tcacctgata tattagccaa
     2581 aggaactcca tctactacat atagagcgtt gttattacct gatatagact tcgtaccacg
     2641 cattaccaca cgggcaccgc ctccaatacc ggatgaactt gcattgatat tcacacccgc
     2701 caccttaccg gcaagactgc tcatcacatt catatctttc gcctttgcca cttcgtcgcc
     2761 gccaatctgc tgcacattgt atgtcaaaga cttggtttcg cgtttaatgc ccaaagccgt
     2821 tacaacaacc tcattcaaga cttttgcatc ttccgtcatc acaatggaaa gcgatttatt
     2881 atctgtaacc ttcacctctt gagaagcata tccaatataa gagatctcca ataccgctcc
     2941 ctttttagct tgaatctgaa agtttccgtc gaaatctgta atagcaccgg tagttgtccc
     3001 ttttactttc acattcactc cgatcaaagg ttctcctttt gtatctttca ctgtaccttt
     3061 tacctgaata gtcggatctt gctctgttac attcaattta ttggtagaca agataatctg
     3121 cttatcaacc actgtataag taatgttggt tcctttaaat acctcatcaa gaatatccag
     3181 gatcttacct gaattgtttc tcacagaaac aatacgattc ttctgaattg ttttatcatt
     3241 ataaaggaaa acatagtcgg acgtctcctc tattttattc agtacctgtt ctacagatac
     3301 attgttcatt gaaatggcaa cccgcgttcg ctgggcatag ccatcttcgg cagaaagttg
     3361 taatactact gcgaaaagta gtgctagact aatcctcata actaaaggaa gttttagatt
     3421 taaagcatat ttaggacata atgctgtaaa tgaatgattt tttttcatac atttgtggct
     3481 aactaaagtt tattactaaa tgaactatgg tttgattccg gctagtgttt gcgagacctt
     3541 gtaccgtgaa tctggaaaat tcggaggaag acagctgttg gtagcagctt tcttcctttc
     3601 ttttattctc ttgtgttatt ccatgggctt ttattttaag ggttactact ctaatataaa
     3661 tctactctaa ttttagtctt tgataatgta tcatctgcct gttgttgcgg ttcttcaatt
     3721 ttccatttta aatcggcaga cctggccaga taatccaata tctgcgacag agtttcagtc
     3781 cggaaagtag cccggtactt atattctttt ccagacctat tgttaaactg aatttctaca
     3841 ttgaaatgtc gttccagacg cttcaggatt tcttctaatg aagcatttct gaaaattagt
     3901 tttccatctt tccaagctat ctttccatag acatccactt tatttttttt cgacttttga
     3961 ctctgtttgt cgtaaagcaa ctgttctcca ggagccaata cgattgtttc ctgatcgggg
     4021 gttatcacat ttaccttacc cttttccaat actgtttcta tataattatc atcctcataa
     4081 gcagctacat taaatttggt accataaaca tatacgctca agccattcgg agtatttaca
     4141 tagaaaggac gatctttgtc tgcctgcact tcgaaatatg cctcaccctt cagttctacc
     4201 aaccggttgt ctttcttgaa agtggtagga taacgcaatg tactacctgc attcaaccat
     4261 actacagaat gatccggaag ttcataacgt atgacagaac cggtagcggt taccacctct
     4321 gcatatttct cgtcggtttc tgttccacta aaatataaat atcccaaaac cagagaagag
     4381 agaaataaag gtatagtcag aaatgctgca taacgcatca gttgattata catattcttt
     4441 cttctattag tttttattgt ggtttgtgct tgataatagg cacccaatac atcaatggat
     4501 tccatttctt taatatcatc tcccaatgct tgtgctttac ggagcaatga ttccggactc
     4561 atattttcca tattttcttt caaaatctta tcttttaatt gtaattacac ttataataca
     4621 actgaagtaa ttggaaaagg acagcaaaaa caaacttttt ttattttatt tttcgagcca
     4681 tgccaaattg aagcggtaat gcaatcggct actaaggata tgaaccacat tatcaggagt
     4741 ttgtgttcct gcaagatagc cacgtggttc agcatgattt tcatccattt cgaaatatcc
     4801 cgtccatgct ccaccgttta aaaaacgata ttcaccgtcc gtcagtagtt ttcttaccgg
     4861 ccatgttttt ccctcatcgt aggaaagagc cgcatacatg ccatatcctt tcttcacatt
     4921 tccattttta tccttaaatt ccagaccacg ttcttccaaa ggcgtacgtt gcggatggtc
     4981 tgtgaaagaa accaatagca aaggtccttc attcagtctc attaaaacaa gacgctgacc
     5041 tccgtcaata ggagggagtt cgcttgctac atatttccag gtctttccca tatcatctga
     5101 tatgctcatt ggcattcgga gctttccttc tttattccgt atgctattac cacgccccat
     5161 agccatcaaa cttccgttcc ctaattgtac aattcccgca tggatacctg cgattgtact
     5221 tcccgttcct ccttctttga aatccggcaa aggagcgcca tcccaaggat cgcaccatgt
     5281 ttttcctcca tctttactga tttgaacagc tgccccgtca tgactgccgg gacccgcatc
     5341 acaggcttga accagccatc cctcacgtgt gcgaatcgta ccagctatta cctgatgacg
     5401 tttggtatgt tcgggagcta tcagtttagg agtgctccat gaagcaccgt tatctgtgct
     5461 ggtacgtagt accattgcga gattctgcca gtctcccgat gcttccactc cattgatatg
     5521 atacaatttt cctttcccgt cattgagcaa agcgcttcct gtcatattcc gatccggaac
     5581 tttaaagaat aaagaagcca catcccaatc agtgtgcccg gcacgcaagc gggaaccgag
     5641 tactaccatc cctctcccat tctcttcatt tgcagaaaac catattgcca gcaaatctcc
     5701 attatcacac cacgtaactg caggctgatg attatgcaga taaaatgggg tattcgaatc
     5761 acataccgga cgtaccacaa atggtatcgg aggcaaaaac atcggtgtga tagcagatac
     5821 ttttttccat tttatagatg tattttctac agatttctga ttgaacggga caggggcaga
     5881 tgttcccgat acattcaaac gagtatctgc ttccacaatt ctaaatccgg tttgggaatg
     5941 tttatcttcc gggagcatag ccagtcgatt ggcacttcgc aagtatttct ccggggtgtg
     6001 atgactccct cctcgagtga cccgaaactc tccggtcaac ggtcctgccg ggtctttctg
     6061 cttttctgcg gaataaggag cataccaatc caagcaccat tcttccacat ttccatgcat
     6121 atcataaagc ccgaatgtat taggaggagt ctgggctact tttaaagata ccggatcaaa
     6181 gtcacgaacc actttttgat tccgatgata aactgcaggt aacccgtctc ctgtagaaaa
     6241 tagtgtgtat gtgcctgccc gacaagcata ttcccattcc gcttctgttg gcaaacgata
     6301 gtttttgcct tctttccggc taagccattc acaaaaggca acagcatcgg aataactcac
     6361 attgacgact gcttcatcat cttccagcga aacaccgttt tttcctcgta atgcccgatg
     6421 ttccggacgg aatgattcat attgcgcatt cgttatttca gtgattccca tacgaaacgg
     6481 gcgagagatt attacctgat ggataggagc ctcatcaaaa tcttcgccta atccgtcact
     6541 tcccatataa aaacttccgg caggtatttc agccatcgga ataaaagact tggaaactcc
     6601 ttgagaatgt attggcaaac aaaaggttat agccaataaa aaaaacttgt ttttcatatt
     6661 ttaatcccgt ttatatataa tacaatcaac ctatatacaa aaggacagcc tcatctgatt
     6721 attttctatt cattagtgtt gaaagcaaaa aaaagaatcg aaaattaggc tttgataatt
     6781 atcttattat atatttgcaa cgaaatgaaa aactacagaa cctcaaaata atgaaaatat
     6841 ctttttctaa acagactaaa gaacgggctt tcaaacaact ttatgaggag tattatgccc
     6901 cattttgttt gtatgcaaaa aggtttgttg atgataaaga aacacgtgaa gacatcgttt
     6961 cggatgtatt cacctcatta tgggataaac tggatactga ttcttttgat cttcaatcga
     7021 acaccgcatt agcttacatc aaaatgtgcg taaaaaatag ctgcctgaat ttcctgaaac
     7081 atcaggaata tgaatggagc tatgcggaaa atatacagaa gaaagctcct gtctatgaaa
     7141 cagaaccgga tagtatatat actcttgatg agctatacag aatgttgtat gagacattaa
     7201 acaaacttcc cgaaaactat cgaacggtct ttattaaaag tttctttgaa ggcaaaactc
     7261 atacagagat tgcagaagag atgaatctta gcgtgaagtc tatcaatcga tataaacaaa
     7321 aaacgatgga acttttacgt aatgaattaa aggagtatat gccactatta ctcttgttat
     7381 ttcttcgtgc ataatctaca tcctcatgtt ctcttcctgg tatatgcctt tcttttgaaa
     7441 aacagtcgta ctctatatat gtattagtcc tgttgtttat atcactctgc ttaatagtta
     7501 gcaggggctt acttgtgtgg acagataagc tatcagttgt gaacaaatcc gtttacggtt
     7561 gtaaacagat ttgttcacat gggtgagccc ttgtaaaaca ttagagctta acaaaagaat
     7621 acctaagtat caatgtatga tatataggga aatatagtat aaattagctg ggaacaagac
     7681 gagccagggt gagggtaact ttttaccctc accctggcct cacctctacc ctcacacttg
     7741 aaacaccgat gaataaaggg attgaatcaa ggtgtgaggg tgtgagggta aaacgtcatc
     7801 aacatttgtt tggctaagat gcgacactct gcccggttta tttttccgtt ctctgtttgc
     7861 ggaatggatt ctattgtcaa tatatgcttg ggacgataat aaggttccag tatttcatgt
     7921 agtttatttc cgatttcttc tgtgtcgggc tgatctgcca ataataaagt gacagcctgc
     7981 cctaagcgct gatccggaac tgaagtaatg acaaaggaca caggaataaa cgggcggagc
     8041 aacttctcca tctcctctgc ttgaatctta attcctccac tgttaatcac attgtctttc
     8101 cggcctagaa tcataaaact tccatcggga tagatacgtg caatgtcatt ggtctgcaat
     8161 gtttcgtcac ataccaaagg ggcatcaatg attaatgtat tctctgcgga taaagacaat
     8221 tttactgaag gaaatggata ataatgttct gaagccgatg ctccgttcag acgacgaagg
     8281 gcaatatgcg acaaagtttc agtcatgcca taagtggagt aaacggcagt cggaagatgg
     8341 tttatctccg tttccagagc ctcatcaaca gctccgcctc ctataatcag aatatccgtt
     8401 tgttttaatc gctctttttc ttcgggaacc tgcatcgtgt tataaacttg caatgggacc
     8461 attgccacaa atctcaaagg ttcttttata tccgccaacg gatgaccgga agcaggacga
     8521 acaatcaggt tcaaacctgc aaccaatgaa cgtacgacca ccatcattgc accgatataa
     8581 cgaagattca tacataataa tgccgactca cctttcttca aattcagaaa ttcacaagtc
     8641 agacgcgcac tttgcatcat ttgatccttg cgtaccatca gttctttagg tatacccgtg
     8701 gaacccgatg tatgaaccgt gatgacagga gagccattaa accattcgtt caggaaaaga
     8761 tataaatccc aataagcaga agaatgagct tctgctcctc ctgctatcaa ttggcttata
     8821 tcttcaaaag tgtattcttt tccttccagt agcaagcgct gttgttgtcg atcgaatatc
     8881 atctgaatat cctttaaata ccactaaata ccatcattta caaaaccaca ggcaatcttt
     8941 tctgatttca agaggcactt ctatattgtc agtaaagagc atacccgttc ccaatccttg
     9001 tggcaacgga ttattgaatg ttgcacacca atgggcgata gcgttcaaac caatgttgga
     9061 ctctaaagcg gaagtgatcc accagccgat atgttgcttt tccgcttcca taatccattc
     9121 atcccctccg catattcctc cgtggagaga tggtttaatg atgatatatt gcggacggat
     9181 ggttgccagc agtttctttt tttcttccag cgtgttgcat cctatcagct cttcatccaa
     9241 tgctatcggc aacggagatt cagaagtgag ccgggccatt tcctcccatt gtccggcacg
     9301 gatcggctgt tcgatagaat gtaaatcaaa ttctgacaga cgtttcagtt tttccattgc
     9361 atcacccgga gagaaagcac cgtttgcatc tacacgcaac tctatttctt tagaagagaa
     9421 atgggtacga atatgacgta acaacgccaa ttctttttca aaatcgatag caccaatctt
     9481 tagtttgaca caacggaatc cggcttccat ctttttctcg atttgggata acatgtgatc
     9541 aaaatctccc atccagatca ggccgttgat tggaatccct acctctccac gtgaaaaagc
     9601 cgtatcggat aaagcccaac tccctgcaaa gaaatgccag atagccgttt ccaaaccaaa
     9661 taagatggaa ggatattggc ataaaacatc cttatcccac attccttgtt ctttctctac
     9721 ttgccgacaa attcttttta atatatcttc ataatcaggg agatcatcac aacttaaagc
     9781 gggcaaaggc gcgcactctc caattcccac tctacccgga aagtcaggag aagtaaagtg
     9841 aagataccag acttttcggg tagtatatat tccccgggaa gttcccgcgg gttgcttgaa
     9901 atgaagcaac cggggaataa tatctatctt acaatccata atgaatatct tttcaatctg
     9961 ctaattactg cacaatcagt ctttcattag cctatcattt ttaagggaat ttcggatatt
    10021 gtttgaagtt cggtttacgt ttctccaaga acgcattctt gccttcctgt gcttcatccg
    10081 tcaggtaata aagtaatgtt gcgtcacctg ccaactcctg aatacctgcc tgaccatcca
    10141 gttcggcatt caatcccgct ttaatcatgc gcaaagccaa cggactaagc aacatcattt
    10201 cttccgccca ctgcacgtat tcatcttcca gttgttccaa aggtactacc ttattcacca
    10261 atcccatatc caatgcttcc tgtgcattat acttccggca aaggaaccaa atttcacgtg
    10321 ctttcttctg ccctaccacg cgtgccagat aagatgcacc gaatccggca tcaaagctac
    10381 ccacgcgagg acctgtctga ccgaaaatgg cattttccga agcaatggat aaatcacata
    10441 ctacatggag cacatgtccg ccaccaatgg caaagccgtt cacggcagca atcacaggtt
    10501 tcggaatact acgaatttgc ttttgtacat ccaatacgct caaacgaggc acaccgtctt
    10561 tcccgatata tccgccacgt cctttcacat tctggtcgcc tcccgaacag aatgccttat
    10621 caccggctcc ggtaattaca atcacatcaa tatccgcttc ttcacggcaa atgcgcaatg
    10681 catcactcat ttcggcagtg gtagtcgggg taaatgcatt ccgataacgt tcacggttga
    10741 tcgtgatacg ggcaattcca ttataataat caaaaagaat atcgtcgtat tctctgatgg
    10801 ttgtccactc tctttgtgtt ggcataattt atttttgttt taattgatga taataattct
    10861 tcaacatacg tgcatccttg tttttgttgg taaacacttc cagaagcaca ggttgttcca
    10921 tagtttccgg ctgggtgaaa gttttcattg cttcagtcag ctcttcatca ttttgcgctt
    10981 gtagataaag gaagccacgt tcctctgccc agcctttagc tgacgtttta tggactgctg
    11041 caataaattt atgtgaggtg cccgacatat ccaatcccgg taaagtatgg aaaatctctc
    11101 ctcctccgtt atttaataaa aggatacgca ggttggaacg gacgttgata ttccacaacg
    11161 cattcatatc atagaagaaa cttagatctc cgatagctat gaaattcagt ttgtcggaag
    11221 ctgccgcata accgacagcg gtagacaacg acccttcaat accactcgtt ccccgattgc
    11281 aacaaacttc aatcgtggaa gggatcgaat atagttgtgc ataacgaact accgaactgt
    11341 ttgccagatg caatgcgcag gactccggca aagctttcaa taatgtaccg acagccaaca
    11401 tttccgaata agcaaactcc ggttcgggaa taatcttaca ataattctcc catacacggg
    11461 gatagtcagg agtccggtta tccagcaggc tggcgatctt ctccagaaac tcgaacgggt
    11521 ccatttcgat caccgtagtt aatgagccgt acaaatcaac cacctcaccg tccggcgata
    11581 cgtgccaatg ttctttaggc ggatgctgac ggagaaactt cttcaatcgt ttggaaacca
    11641 catgtcctcc gtaagtaatc agcaattcgg gcaccatctg gtctatcttc tcttcgggca
    11701 tggcataaag tgccgcatcg aaattcttta ccggaatacc gggaactgtc tgattgccga
    11761 tatgttccgt caaccaggca aaatgtttat ataataactt gatatatctt ttttcaaaca
    11821 ggtagataag gttcatctgg ccgatgataa tcatgcgctt ctgatattta ttcatccggt
    11881 cgaccagatc attataatca cggtcataga cgttcaatcc ctgataacgg gttatcacac
    11941 gtacttccgg gagtgcatct accgtgaatt gaaacagcgg ttcggaaata ggaacattga
    12001 tatgcaccgg cccttttcca tgatgattcg tctccagcaa agcttcattc accaggcgat
    12061 tacaatacca ttcatcttct tccgtatgaa tctccggaag attgaccgac ttctttacca
    12121 gcgtttgaaa cacacccggt tgcggcactg tctgtccatc catctgtccg atccaggcag
    12181 cgggacggtc tgctgaaatg acaactaaag gaacattctg ataaaatgct tccgctacag
    12241 ccggatgaag atttaataat gcagtaccgg aagtgcagca cacagcagcg ggcttaccac
    12301 cattcaacgc aagaccaata gcaaaataac cggcactccg ttcatccgtc actgcataac
    12361 aggtgaagtt cggatgatta gacaaagtat gtacgatggg cgtattacga ctacccggac
    12421 acaacacaac cttagtaatc ccgtgcgcct cgagcaacgc aaccaactgg agtatgttct
    12481 tcttgtctgt atacatgatg ataattatta gtagtttatg attttaaagg aggcgttgca
    12541 atcagccgtt tgatggtttg caacttcttt tccgtttcca gccattcgtc attcaattcc
    12601 gaagaagcca gtagtccacc gccggcataa agagtcagtt gttcatcttt aatatgcata
    12661 cagcgcagat tcacatagat gtcagttcgc ccttccgggt ccagccaacc gataaaaccg
    12721 gaataataac ggcggtcgta accttcgttc tgcaatataa accgataggc ttcttctttc
    12781 ggtaaaccgc atacagcagg cgttggatgc aacactttca agagatctcc caaacctttg
    12841 ttatctttca aagaaaaccg gaaatctgtt ttcaaatgtg acaaagcacc tgcataagcc
    12901 ggataaggcc cgttctccgt agaatgaatg cccaacgata ggagttggcg acgaatataa
    12961 gaagcgacat aatcctgctc tttccggttc ttttcatccc acacttgcgg cagtctgcca
    13021 tcttgtaaag gctgcgttcc ggctaacgca accgtatgcc attcgtcttt ttcacctgat
    13081 aaaatgattt caggagtgct tcccagccag atacccgtct gcggagtgta gcacaagtat
    13141 atatatgaat gaatataacg cctgcacgct gcacgaaata tagacaaagg agaaaaaccg
    13201 gatactttat caatagtaag atgacgtgaa agtactaatt tatcaaaagt attatcacgc
    13261 aaagcattta taaaggtatg aaagcaggag gcatattcct ccgtagaaga agtcaggaac
    13321 gattcttgtc cttgcatccg caaagcgact tcccgttctt ctgccgtatc attgtcaatc
    13381 ggcaaaggtt gcccccactg atcgggttga atcaatacga caggacacgt ctcactcacc
    13441 tgaaacggag caattacaaa tcctctctgt ccattcagtt ctttcaaatc gtatatcaaa
    13501 cggaccgctc cttccgcctg tgtcaacaga cggggaactt tctccccggg aatgcggtaa
    13561 acagcaaacg gctgcttccg ctgaataaat gcatcaatag ttgtcaaatt acttatttct
    13621 tcgtcggtca tctctttttc atcacactgt tgactacccg tatggaagac actagtttgt
    13681 ttgttgaagt aaacacgtct acattccata catgggagga acgtccctta tgtacaactg
    13741 ttcctactgc acgcactgta tctccttcat gtgcagaaga tatgtggttt ccactgacct
    13801 gcattcctac tacaatctcg tccggctggc aaagaatcat tgaaccgagt ccggcaactg
    13861 tttccgccaa tgcaagagta gccccgccat gcaaaatgcc aaaaggctga cgggtacgat
    13921 ggtctaccgg cattgttgct tccacacggt cttcgtcggc ataggtatat tgaattccca
    13981 agtttcccat caatgcgtgg cgtgcctgcg cattcagttg gtcaagggga atttcggctg
    14041 cacgcacttc ggatatgata gccttctcca ctgcaacggc cactccgtct tcctcattcg
    14101 aagcagtcac ataatcggca caggctttca ccgagtcttg tgaatgtccc atagctatgc
    14161 ccagccccgc caattgaatc attgttacgt cacacacacc gtcgcccaca gcaatcactt
    14221 cctcacgctt catacctagc acctccagca aagcacccaa agaattggct ttgtcgatgg
    14281 cgcagggaac tacttccaga aaatagggct ccgaacggaa tacgtccaac gccccattca
    14341 gtcgtctctt ccagtgatct tccaaaccaa gcaatgcttc ttcgtcatcg ctcaccagca
    14401 tacacttaca aggagcaaaa tcaacggcag cagaaaattc ttcttctttg attatttgca
    14461 ggtcattcaa ccgggcttca ttttggatat gttcattttc aggagaatcc gttatgatcg
    14521 tatcatcatg ataagtgaat aaagcaaaac cgtttttacg ggctttcttt tccagatacg
    14581 gcaacatttc gggattaatc cgacgttcaa acagaatttc tccgttttgt gcattgataa
    14641 tctgacagcc attataggaa aggataaaac ctccatagtt tccaagttcg agcatcttgg
    14701 ccagcggcat caggccataa gtcggtctgc cggacgccag cacaatacgt actcccattt
    14761 gctgaacctt caacagggca gccaatgtac gtttactaat ttctttcgca tcattgagga
    14821 gtgttccgtc tacatcaaga accaataatt tatacttcat gattacacga t
//
