LOCUS       c00069_gnlPro..        14571 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KJIABEKM_69.
ACCESSION   c00069_gnlPro..
VERSION     c00069_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 20:30:00
            Original ID  :: gnl|Prokka|KJIABEKM_69
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14571
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14571
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[14:4571]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      15..4571
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14571
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14571
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             15..419
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_1"
                     /sec_met_domain="Glyoxalase_4 (E-value: 9.2e-24, bitscore:
                     75.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAEGKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             448..2001
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_2"
                     /sec_met_domain="CT_Btheta (E-value: 5.7e-290, bitscore:
                     952.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             2033..2953
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_3"
                     /sec_met_domain="OAD_gamma (E-value: 1.9e-15, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQNNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWIGLFDSGRKLLDQIVVPAGVLGPNQSYARVSDGAAEW
                     EVKGGSGDKYVTPSTNNKTLDSNAKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             2978..3409
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.1e-21, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPA
                     AKPVTVRPMPNAPTAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             3411..4571
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_5"
                     /sec_met_domain="OAD_beta (E-value: 7.6e-153, bitscore:
                     499.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLGFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             4866..6206
                     /locus_tag="ctg69_6"
                     /transl_table=11
                     /translation="MKRIIILFFLCCTIPLIAQHTDPIQEAMANYDYETALSLIAQKKT
                     TPPLLLQKGKALRGLGLTTEALATYQEIICNDTTNTRAFIEAAECCRALAKYNQALKYY
                     EHALDLNPENKYVRIQYISLLLSQQKFSEALGESSLMTEKDSSAIVLHLQAQSFEGMGE
                     LLPAAGCYYNIQAKYPDDYLAASKLGALNISGSYFDEAIEATEKYRQIDSTNISVNRQN
                     ALAYCLKQDYPTAIRRYEYLVSQGDSSFHTCYYLGISYYAAEKYYEAHDFLEVARKYDP
                     NNINLLYYLGRACSKTSWKKEGVDYLEKTIDLSIPKDSSMTRLYIGMTDCYKMAQMYKE
                     QIASIKERYQRYDKQNHKLLYDMAYIYFYDLKDKKNAERYLEAFLKTRPKDTKEEAEMN
                     ERGELVLGKSNYYNAAAKWLKDIQSKQKIEDFFQNSSPQLPLPKKDK"
     CDS             complement(6291..7295)
                     /locus_tag="ctg69_7"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPEEEVETINKYGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKILNVLGSDNKLAQ"
     CDS             7729..7983
                     /locus_tag="ctg69_8"
                     /transl_table=11
                     /translation="MKKGLHPESYRPVVFKDMSNGDMFLSKSTVATKETIEFEGETYPL
                     LKIEISNTSHPFYTGKSTLVDTAGRVDKFMSRYGDRKKK"
     CDS             complement(8063..9277)
                     /locus_tag="ctg69_9"
                     /transl_table=11
                     /translation="MINREQYMEQIVPFIDKPFVKVITGIRRSGKSVVLRLIRDELLRR
                     GVREERIIYLNFESFQWIDLKEAKALYAYIRGQAGDAGKYYILLDEIQEVDGWEKVVNS
                     LLVDLDTDIYVTGSNSRMLSSELATYLTGRYVAFHVMTLSFREYLTFHDLQANDPTLNR
                     KEEFQKYLRMGGFPAIHTADYGYEAIYKIVYDIYSSVILRDTVQRHNIRNVELLERVVK
                     FVFDNIGNKLNAKNIADYFKSQQRKVDMNTIYNYLNALESAFIIQRIPRYDIKGKEILQ
                     TNEKYFVSDLSLIYSVMGYRDRLIAGMLENLVCLELKRRGYEVYVGKQDDKEVDFVAIR
                     REEKIYVQVTYQLASQATVEREFAPLLAINDHYPKYVVSMDSLWQDNVEGVRHRHIADF
                     LLDDA"
     CDS             9495..9878
                     /locus_tag="ctg69_10"
                     /transl_table=11
                     /translation="MTKEEVFNFIRQRLSFSKELQEQFRHVNKDDLAKEHRRFEMSGNE
                     SKTGQCTIFNTAILNEFADLGIYDYTSYLFLDFHNGTPTVYLKYFSENENLEYTFTGYT
                     TTEIIFAILELTIFSGKPKRNRS"
     CDS             10610..11041
                     /locus_tag="ctg69_11"
                     /transl_table=11
                     /translation="MPKWISVEKAVIKYHIEKEAILLWVEMGQFPMLYIDNVPNVDEEC
                     ILELFRRSKAGITAEYIDTLEQLCIDKTMVCEKYAHIIQLKEKEIQLQKEINTSINEIQ
                     AAMKRQNERIRDLKKAIGENNNVIRSDSWIKRLRKRFQW"
     CDS             complement(11242..11586)
                     /locus_tag="ctg69_12"
                     /transl_table=11
                     /translation="MHVIVWEKPVGGVFVVGAAEIVFIFCQCPCNGKAGSVCSLQAEIG
                     VVPSHPVYQFFYLVCTAHRFSQCQQCAVILFRILADNSCPTGNRQATVILHRFFHTDFF
                     VLKCSHFSSC"
     CDS             11991..13295
                     /locus_tag="ctg69_13"
                     /transl_table=11
                     /translation="MTTSNSANTKQSNNASQKRKPIHNGYFNHPTSSSSNIPMSILIRE
                     QGLEIYGLYWVMLEEAHAQLKCCVNIQTMGIIANIFHAQPEHLELLYHHYFRRPGKGYN
                     SHILYADFCEESAIRSYFPHPLLAYTDNELLRMIMQDGLKAYGLYWLVMEKLYQQPQHF
                     LAPQTASFIQNLYDVSDELMESVLYNYGLFYLDEKMNLHSKAIDDYREALDNMEDEKKR
                     NTKPHVNNSLKANGNAEDFNTREMKNTSNIQKNPSPIINKEINKKNSSSEESGKEKEEE
                     NGLKVTDLNAVTPDMRPNAWEENLQEAMNDTSWYEVVAIQSGIPRLMMEEKEWFFNYLR
                     EQIILRGNESSMNSLHEIKNYFANLTRQGSHVSSTTQVALKKFLKNRQEQQQCSPYETI
                     TNGIRTYDGHPIPAYAKPRPSAAHIWNPVTNEWTR"
ORIGIN
        1 aaaaaagtat agttatgaag atttcacaca ttgaacatct gggcattgct gtaaaaagca
       61 tcgaagaagc ccttccttac tacgaaaatg tattaggtct gaagtgttac aacattgaaa
      121 cagtggaaga tcagaaagta agaactgctt ttttaaaagt gggcgaaaca aaaattgaac
      181 tgttggagcc tacttgcccg gagagtacta ttgccaaatt cattgaaaac aaaggtgcag
      241 gcgttcacca cgtcgcattt gctgtagaag atggcgtagc caatgcgctg gcagaggcag
      301 aaggcaaaga aatccgcctt atcgacaaag ctccccgcaa aggtgctgaa ggtttgaata
      361 tcgctttcct tcacccgaaa tcaactttgg gtgtgttaac agaactctgc gaacattaat
      421 cataaactct aaaaccaaca agaactcatg agtaatcaac ttgaaaaaat taaagagctt
      481 attgaacgcc gtgccgtagc acgtatcgga ggcggtgaaa aagcaattgc gaagcaacac
      541 gaaaaaggga aatacacagc acgcgagcgt ctggctatgc tgcttgacga gggtagcttc
      601 gaagaaatgg acatgttcgt tgagcacaga tgcacgaact tcggcatgga gaaaaaacat
      661 tacccgggag acggtgtagt aaccggctgc ggtacgatcg aaggacgtct ggtatatgtg
      721 ttcgcacaag acttcactgt ttctgccggt tcactgtcag aaacgatgtc attgaaaatt
      781 tgtaaaatca tggatcaagc catgaagatg ggcgctccct gtatcggtat caacgactcg
      841 ggtggtgcac gtattcagga aggtatcaac gctttggcag gttatgcaga aatcttccaa
      901 cgcaatatcc ttgcttccgg tgttatccca cagatttcag gtatcttcgg tccttgtgcc
      961 ggcggtgctg tttattctcc ggctttgacc gacttcacgc taatgatgga aggtacttct
     1021 tatatgttcc ttaccggacc aaaagttgtg aagaccgtaa caggtgaaga cgttagccag
     1081 gaaaacctcg gtggcgcaag cgttcactcc actaaatcag gtgtgactca tttcaccgct
     1141 aaaacagaag aagaaggttt cgaactgatt cgtaaactgt tgagttatat tcctcaaaac
     1201 aaccttgaag aagctcctta tgtagattgt acagacccaa tcgaccgttt ggaagattct
     1261 ttgaatgata ttatccccga cagccctact aaaccgtatg acatgtacga agtgatcggc
     1321 gctattgtgg acaacggtga attccttgaa atccagaaag attatgcaaa gaatatcatc
     1381 atcggtttcg cccgtttcaa cggacaatcg gtaggtatcg ttgctaatca gcctaagtat
     1441 ctggctggtg tgctcgacag caacgcatct cgtaagggtg cacgtttcgt tcgtttctgc
     1501 gatgcattca atattcctat cgtatcgtta gtagacgtac cgggattcct tccgggaaca
     1561 ggtcaggaat acaacggcgt tatccttcat ggtgctaagc tattgtatgc ttacggtgaa
     1621 gctactgtgc ctaaggttac tatcacattg cgtaaatcct acggtggttc tcacatcgta
     1681 atgagctgta agcaacttcg cggtgacatg aactacgcat ggccgactgc tgaaatcgca
     1741 gtaatgggtg gagcaggagc agtagaagta ttgtacgcac gcgaagccaa agatcaggaa
     1801 aatcccgctc aattccttgc tgaaaaagaa gcagaataca cgaaactgtt tgccaatcct
     1861 tacaatgcag ccaaatacgg ctacatcgac gatgtgattg aaccacgcaa cacacgtttc
     1921 cgcgtaatcc gtgctttgca gcagttgcag actaagaaat tgagtaatcc ggctaagaag
     1981 catggtaata ttccgttgta atcctacttt tcacattaaa acaagaacga ttatgaacaa
     2041 aaccaaaatc ggaatattcc tttctttgct gttgctgatt gggctgactt cttgtggaga
     2101 gcaaaagtcg aacaacaagc tggtactgaa cgaaatcctg atagacaatc agaataattt
     2161 tcaagatgac tacggattgc acagcgcatg gattgaaata ttcaataaat cattcggtag
     2221 cgccgacctg gcagcttgct tgttgaaagt aagcagccaa ccgggcgata cagttactta
     2281 ctttatcccg aaaggtgata tacttacatt agtgaagcca cgtcaacatg cactattctg
     2341 ggcagatggc gaacctaacc gcggtacttt ccacaccagc ttcaagctga atccggaaac
     2401 ggccaactgg atcggtctgt ttgactccgg tagaaagctg ctcgaccaga ttgtagtgcc
     2461 cgcaggtgtt cttggcccca accagtcata cgctcgtgtc agcgacggag cagcggagtg
     2521 ggaggtaaaa ggtggaagtg gtgacaaata cgtgaccccg agtacgaaca acaaaactct
     2581 tgacagcaat gccaagatgg aaaaattcga agagcatgat gctgacggtg tcggcatgtc
     2641 catctctgcc atgagtgtag tattctgcgg attgattctt ctctttattg ccttcaagat
     2701 tgtaggaaaa gtagctgtaa atttgagcaa gcgcaatgct atgaaatcta aaggcattga
     2761 caagcatgaa gctaaggaac tgtcacaggc tccgggcgaa gtttacgctg cgatttctat
     2821 ggcattgcac gaaatgcagg atgaagtgca cgacgtagaa gaaacggtac tgaccatcac
     2881 tcgcgtaaaa cgcagttact caccatggag ttcgaagatt tacactttgc gtgaaactcc
     2941 tcccagaaag taagtcacct tttaaaaagt taaaacgatg aaagaatata aatataaaat
     3001 caacggtaac tcatataaag taaccatcgg agatattgaa gataatatcg ctcatgtaga
     3061 agtgaacggt acacactata aagtggaaat ggagaaacag ccgaagcctg ctgccaaacc
     3121 tgtaacagta cgtcctatgc ctaatgctcc tactgctcct actcaggtag tgaaaccgac
     3181 tgctccgtct accggaaaat caggagtgaa atctccgctg ccgggtgtta tcctcgacat
     3241 caaagtgaat gtaggcgata ctgtaaagaa aggacagacc attatcatat tggaagccat
     3301 gaagatggaa aacaatatca atgcggataa ggacggtaag attactgcca tcaacgtcaa
     3361 caagggagac tctgttcttg aaggtaatga cctcgtaatt attgaataat atgggagatt
     3421 ttataaactt tttaggaaat aacctcgccg acttctggac atacacgggc tttgcaaatg
     3481 ctactgtagg gcatgtcgtt atgattcttg tgggtttggg gttcatctat ttggcggtag
     3541 ccaaagagtt cgaaccgatg ctgctgattc ctatcggctt cggtatgctg atcggtaata
     3601 taccttttaa tatggatgcc ggactgaaag tcggtattta tgaagaaggt tccgtattga
     3661 atatattgta tcagggagta acttccggct ggtatccgcc gctcatcttt ttgggcatcg
     3721 gcgccatgac ggacttctcg gcacttatct ctaatccgaa attgatgttg atcggtgctg
     3781 ctgcacaatt cggtatcttc ggtgcttaca tgatcgcatt ggaaatgggc ttcgacccga
     3841 tgcaagccgg cgctatcggt atcattggtg gagcagacgg cccgacggcc attttccttt
     3901 cttccaagct agcacctaac ctgatgggag ccattgcggt gtccgcctac tcctatatgg
     3961 cgttggttcc ggtgatacag ccgcctatca tgcgtctgct caccaccaag aacgaacgtg
     4021 tcatccgcat gaaaccgccg cgtgccgttt ctcacacgga gaaggttatt ttcccgatta
     4081 tcggcttgtt gctgacctgc ttcctggttc cttccggtct acctttgttg ggtatgctgt
     4141 tcttcggtaa cctgttgaaa gaaagtggtg taacccgtcg tcttgccaat acagctagcg
     4201 gtccgttgat tgatactatc actatcctgt tgggtctgac agtaggtgct tctacgcaag
     4261 cttccgaatt cctgacgctc gattctatca agattttcgc cctcggtgca ttgtcattca
     4321 tcattgcaac tgcatccggt gtaatcttcg ttaagatatt caatatcttc ttgaagaagg
     4381 gcaacaagat caatccattg atcggtaatg caggggtttc tgctgtcccc gactctgcac
     4441 gtatctcaca agtgattggt ttggaatacg attcgaccaa ctatttgttg atgcacgcta
     4501 tgggtccgaa cgttgccgga gtgatcggtt cagctgttgc tgccggtatc ctgctcggat
     4561 tcttgatgta agatataagg aggctgtttg aacagttctt aaaataaaaa ataagactat
     4621 cctaaaagcc ttgaatttat aaaaatcacc tttgctacat tatagtagta aaggtgattt
     4681 ttcattataa ggacttgctg taaaaaagac tgtagctacc atgccccatg tattgtattg
     4741 cgcactgttg tgttaccttc tcttatcatt ccgttaatct atccaaaata atctacgaat
     4801 aattcgtaaa tataatattt ttagtaactt gcagcagata agtcaaacaa ctaaaataaa
     4861 atattatgaa acggattatc attctgttct ttctttgttg taccattcct ctaatagcgc
     4921 aacacacaga ccctattcaa gaagctatgg caaactacga ttatgagacg gccctttctc
     4981 ttatagctca aaaaaagact acccctcccc tgctattaca gaaaggcaaa gcgttgcgtg
     5041 gactaggact cactacagag gcacttgcta cctatcaaga aattatctgt aatgatacta
     5101 caaatactcg tgctttcatt gaagcggccg aatgttgccg agcactagct aaatacaatc
     5161 aagcactaaa atattatgaa catgcacttg atctgaatcc ggaaaacaaa tatgtacgta
     5221 ttcaatatat cagcttgctt ctctcccaac agaagtttag cgaggcgctt ggtgaaagta
     5281 gtctgatgac agaaaaagac agttccgcca ttgtcctgca tctacaagct caaagctttg
     5341 aaggaatggg cgaacttctt cccgctgcag gttgctatta caatatccag gctaaatatc
     5401 ccgacgatta tctggcagcc agcaaactag gtgctctaaa tatatccggt tcttatttcg
     5461 acgaagccat cgaagctaca gaaaaatacc ggcaaattga cagtaccaac atttccgtca
     5521 accggcagaa cgctttagcg tactgcttga aacaagacta ccccactgct atccggcgtt
     5581 atgaatatct tgtcagccaa ggagacagtt cttttcatac ttgttattat ttaggcatca
     5641 gttactatgc agcagagaag tactatgaag ctcatgattt tttggaagtc gcccgtaaat
     5701 atgatcccaa caatatcaat ctcctttatt acctcggtcg cgcctgttcc aaaacttcct
     5761 ggaaaaaaga gggcgtagac tatctggaaa aaaccattga tctatccatt cccaaagata
     5821 gcagtatgac tcgactttac atcgggatga ccgactgtta caagatggca caaatgtaca
     5881 aagaacagat tgcatccatc aaagaacgct accagcggta tgacaaacaa aaccacaaac
     5941 tattgtatga catggcctat atatacttct atgacttgaa agataagaaa aatgcggaac
     6001 gctatttgga agcattccta aaaacacgtc ctaaagacac taaagaagaa gcggagatga
     6061 acgagagagg cgaacttgtt ttaggaaaat ccaattatta caatgccgcc gccaagtggc
     6121 tgaaagatat tcaaagtaaa caaaagatag aagacttctt tcaaaattcc tctccacaac
     6181 ttcctctccc aaagaaagat aaatagataa gaactataaa gcaactaaaa ggctgctacc
     6241 ggtttatcgg tagcagcctt tcttttattt atggaataat ccggagatta ttactgtgcc
     6301 aatttgttgt cagaaccgag cacattcaga attttgtgct tgtacagttt ttccatattg
     6361 tcacgagccg ggccaagata cttacgtggg tcgaattcag ccggtttttc agcgaatacc
     6421 ttacgtatag cagcagtcat agccagacga gagtcagagt cgatgttgat tttgcaaaca
     6481 gcagacttag cagctttacg caattcttct tccggaatac cgatagcagc tttcagtgca
     6541 ccaccatatt tgttgatagt ttccacttct tcttccggaa ctgaagatga tccgtgaaga
     6601 acgataggga atcccggaag tttttccatt acagcgtcca atacttcgaa agccaatgga
     6661 ggaggaacca tacggccagt cttcgggtcg atgtggcatt gttccggagt aaatttgtaa
     6721 gcaccgtgag aagtaccgat tgagatagcc aaagagtcgc aaccagtgcg agtagcgaag
     6781 tcgattactt cttcagggtc agtatatgtg tgatggtcgg aagaaacttc atcttctaca
     6841 ccagccaata cgccaagttc accttctaca gttacgtcaa actggtgagc gtattcaaca
     6901 actttcttag tcaatgctac gttttcttcg taaggaagat gagaaccgtc aatcatcact
     6961 gaagagaaac ctgaatcgat acaagatttg caagtttcga atgtatctcc gtggtcaaga
     7021 tgaagaacga tttccggatg tgcgcagcct aattctttag catattctac agcaccctgt
     7081 gccatgtaac gcaacaaagt agcgttagca tactgacgag cacctttaga aacctgaaga
     7141 atcacaggag atttagtttc aacagcagcc ttgatgatag cctgcatctg ttccatattg
     7201 ttgaagttga atgctgggat agcgtatcca cccttaatag ccttagcaaa catgtctcta
     7261 gtgtttacca atcctaagtc tttgtaatta accattttgt ttaaagttta ttgttagtga
     7321 ataaaaattc tacgcaaaag taagcattat ccatcgaata acgaacatcg gaaagaaaaa
     7381 tatagtagaa aaaggtttaa atcagactgc aaaatttagc aggaatacga gtgtgacatt
     7441 agattgtaat gtccaccttg caaactttgg gatttatgat ttctgaattc tgattgatgc
     7501 cttcggattt atatctcctt atttatacct tatttatacc tcatttttca ttcatttaat
     7561 caccaaaatc tgcatagcca atcagaaatc ataaattaga aatcagaaat tttagaaaac
     7621 ctttttctat ttcacagaaa agcattatct ttgcgctctg aaaatgacca ttacactatt
     7681 tcttaccaaa atagtaacag aatataaatt aaaaaaacag atactgaaat gaaaaaaggc
     7741 cttcatccag aatcataccg tccggtagta ttcaaagata tgtccaatgg tgacatgttt
     7801 ttgtctaaat caactgtagc aactaaagaa accatcgaat tcgaaggtga aacttatccg
     7861 ttgctgaaga ttgaaatctc aaacacttct cacccgttct atacaggtaa atctacattg
     7921 gtagatactg caggtcgtgt tgacaagttc atgagccgtt acggtgaccg taagaagaaa
     7981 taattcgatc tttcgtgaaa gatgaaaaag aggagattct cgcagagaat ttcctctttt
     8041 tcgttttcta tattccttaa cgtcaagcat catccaacaa gaaatcggct atatgacgat
     8101 gcctgacacc ctccacatta tcctgccaca agctgtccat gctaactaca tatttaggat
     8161 aatggtcgtt aatggcgagc aaaggagcaa actccctctc aacagtggcc tgtgaagcta
     8221 actgatacgt tacttgcaca taaatctttt cttcccgacg gatggctaca aaatccactt
     8281 ctttatcatc ctgtttgcct acatacactt cataccccct tcttttcaac tccagacaga
     8341 ccagattctc caacatacct gcaatcaacc ggtcacgata gcccatcacg gaataaatca
     8401 aagaaaggtc gcttacaaaa tacttctcat tcgtctgcag aatttccttt cctttaatat
     8461 catatcgggg aatacgttga atgataaaag cactttccaa tgcattcaga taattataga
     8521 tggtattcat atccaccttc cgttgctgac ttttgaagta atcggctata tttttagcgt
     8581 tcagcttatt gcctatatta tcgaaaacaa acttcactac ccgttcgagc agttccacat
     8641 tccggatatt gtgacgctgc accgtgtcac gaagaatgac agaagaatag atgtcgtaga
     8701 caattttata gatagcctca tatccataat cggcagtatg tatggccgga aatcctccca
     8761 tacggagata tttctgaaat tcctccttcc ggttgagcgt cggatcattg gcctgcaagt
     8821 catggaaagt cagatattct ctaaaagaca aggtcatgac atggaaagcg acataccgtc
     8881 ccgttaaata agttgccagt tcggacgata acatacgtga gttggagccg gtcacataaa
     8941 tatccgtatc caaatctacc agaagtgagt tgaccacttt ttcccaaccg tccacttcct
     9001 gaatttcatc caagagaata taatatttac ccgcatctcc tgcctgcccc cgaatataag
     9061 catacaaagc cttcgcctct ttcagatcta tccactgaaa actttcaaaa ttcagataaa
     9121 tgatacgttc ttcacgaact cctctcctca acagttcgtc acgaatcaga cgcagcacta
     9181 ccgactttcc actgcgacga atacccgtta tcacttttac aaacggctta tctataaaag
     9241 gaacgatttg ttccatatac tgttcacgat taatcatatt caaaagtttt tagggttata
     9301 agcacaaaga tatactattt tcggaaagtt tttagggtta taaccctaaa taaatccata
     9361 aattcagatt cttttagggt tataagccga aaaataaata aaagaaatat gactaaatcc
     9421 gatttattac caaataaaga aagtaccttt accccaataa ttaataaaaa atggaaataa
     9481 ccgatttaaa acaaatgaca aaggaagaag tttttaattt catcagacaa cgcctttctt
     9541 tcagtaaaga actgcaagaa caattcaggc atgtgaataa agacgatctc gcaaaagaac
     9601 atcgcagatt cgaaatgtcc ggaaatgaat caaagacagg ccaatgcacg attttcaaca
     9661 cagcgattct gaacgagttt gccgatcttg gcatctatga ttatacttct tacctttttc
     9721 tcgacttcca caatggcact ccaaccgttt atctcaaata cttctccgaa aatgaaaatt
     9781 tggaatatac atttaccgga tataccacaa cggaaatcat ctttgcaatt cttgaactga
     9841 ctatcttctc cggaaagccc aaaagaaatc gcagctaaaa aaagaattgc acggaaagac
     9901 aatacgaggt caaaagactt ttatggcttt catttaagca cggattacac ggatttcacg
     9961 gttccattag actaaaaccg tgaaactcgt gtaatccgtg cctaaataat atcaatctaa
    10021 tagatggttt tacttttggc tccctccttt ttatcatcac attatatttg ccacccgtat
    10081 agcatattta ccatctttat accatactct ctattctcat accatatttc ctgcatttat
    10141 ttcctctttt ccatcctatt ccgaaaaaaa catatatctt tgtcatacgc tttctgccca
    10201 tcagcgtgat gaaacaggca aaagcggttt ttattcctta atggagtaaa taacgtattg
    10261 tttcccaaat cgaaacttag caaatttcat gcaccgggaa atgatacaac agatactcca
    10321 cgtagatgat cgtatatcaa catatcgatt agagatttgt tatatataaa cgtttggcgt
    10381 gggtgtctgt tgtttatcat tatctggtgc acggtatgct aagacctcga tttagataat
    10441 ggtacaacag cactcacgct tttattgtat ccggtcggtt tcaacaatcc ttatacccca
    10501 accaattccc cacccgaccg aaatcataaa aatcgtgggt gttcgttgca cctctccgga
    10561 caatacgtta tttactcctt tttttataac acattaaaac aaaagcaata tgccaaaatg
    10621 gattagtgta gaaaaagcag tgattaagta tcacatcgaa aaagaagcga tcctgctttg
    10681 ggtggaaatg ggacaatttc ctatgttata catagacaat gttccgaatg ttgacgaaga
    10741 atgtattctg gaactctttc gccgaagtaa agccggcatt acagcagaat atattgatac
    10801 gctggaacaa ctgtgcatag acaaaacaat ggtctgcgag aaatacgccc acattattca
    10861 attgaaagaa aaggaaattc agctgcagaa ggaaataaat acgtcgataa acgaaataca
    10921 ggcagcaatg aagagacaaa acgaacgaat ccgggatttg aaaaaagcga ttggagagaa
    10981 taacaacgtt atacgtagtg acagttggat aaaaaggctg cgcaaaaggt ttcaatggtg
    11041 aaagagggcc gtcctttgcc ctttgcagcc tatttccatt ccctccacag ctttctttaa
    11101 actcctccat aagctcttta aagcctatat tcagacaatg aaaaaataca aaatatttta
    11161 ttccatttat ttaactaatc atctattata taagtaattt tatcctttgt aaagtcaagt
    11221 aaattcacta catttacacc actaacaaga actgaaatgt gagcatttca gcacaaagaa
    11281 atctgtatga aaaaaacgat gaagaatgac agttgcctga cggtttcccg tcgggcagct
    11341 attatccgcc aagatgcgga agagaattac ggcacactgt tgacactggg agaatctatg
    11401 cgccgtgcat accaagtaga agaactgata gaccggatga gatgggacaa cgccgatttc
    11461 tgcctgcaac gaacagacgg aacctgcctt tccattacag ggacactgac agaatatgaa
    11521 cactatttcg gccgccccta ctacgaaaac ccctccaaca ggtttctccc atactatgac
    11581 gtgcattgta gaaaatggct tacgtgtcga gtggcaggga ttgtattcgg ctcttctgtg
    11641 aaaaaaaatt aatttcatgg attaaataag gaaagttgta ggacatatac gaaataaagt
    11701 agttactttg caaccgcaag taagagaaaa aatcatgtca atgctgcttc cttgtttttt
    11761 gacagaagca gttatctgtt tttccagcat tgctttttca gaacttcgga attaaatctc
    11821 ccctgctccg aaaattccct atattacaga ttacatacac gaagagaata ctccgattcc
    11881 atcatgaaga atgagtacga tatttgctgc tttccaaaga agtggccgga ttcttcgtat
    11941 ctgtattttc agaaaaatag aatttaaaac agaaactaat atattttatt atgacaacat
    12001 ctaattcagc aaataccaaa caatcgaaca acgcatcaca aaagagaaaa ccgattcata
    12061 acggttactt caatcatccc acttcttctt ccagcaatat acccatgagt attttgatac
    12121 gggaacaagg actggaaata tacggactat actgggtgat gctcgaagaa gctcatgcac
    12181 agcttaaatg ctgcgtcaat atccagacaa tgggaatcat cgccaatata ttccatgccc
    12241 aacccgaaca tcttgagctc ctctaccacc attatttccg gcgtcccggt aaaggataca
    12301 actcgcatat actctatgcc gacttttgcg aagaatctgc catcagaagt tatttcccgc
    12361 accccctact ggcatacacc gacaacgaac tgctgcggat gattatgcaa gacggactga
    12421 aagcctacgg actatattgg cttgtgatgg aaaagctcta tcaacagcca caacattttc
    12481 tggcaccgca aactgcttcc ttcatccaga acctttatga tgtgagcgac gaactgatgg
    12541 aaagtgtatt atacaattac ggactctttt atctggatga gaaaatgaac ctccattcta
    12601 aagcaataga cgattatagg gaagcacttg acaacatgga agatgaaaaa aagcgcaaca
    12661 cgaaaccgca cgtcaataac tctctgaaag ccaacggaaa tgcagaggat tttaacactc
    12721 gggaaatgaa aaatacgtca aatatacaga aaaatccatc ccccattata aataaagaaa
    12781 taaacaaaaa aaattcttct tctgaagaaa gcggaaaaga aaaagaagaa gaaaatggtt
    12841 tgaaggtgac ggacttgaac gctgtgacac ccgatatgcg ccccaacgca tgggaagaaa
    12901 atctacagga ggcaatgaac gacacatcct ggtatgaagt cgtagccatt cagtcgggca
    12961 tcccccggct gatgatggaa gaaaaagaat ggttcttcaa ctatttacgg gagcaaatca
    13021 tcttacgggg gaatgaaagc tcgatgaaca gcctgcacga aataaaaaac tatttcgcca
    13081 atctcacccg gcagggaagc catgtgtcat ccacaacgca ggtggcactg aagaagtttc
    13141 tcaaaaaccg gcaagagcaa cagcaatgtt cgccctacga aaccatcacc aacggaatac
    13201 gtacctacga cgggcatccc atccccgctt atgccaagcc gcgaccttcg gcggcacata
    13261 tctggaatcc ggtgacgaac gaatggacac gatagcatat tatctctcaa tcatttacta
    13321 aatatggata gattcaaaga actgggtatt gatacccacg gtcgcacaag cggcaaaatg
    13381 aaaacaaaat gtccctggtg tcatgcccaa cggacggata agcgtgataa atcactaagt
    13441 gtcaacctcg ataccaaact gtatttgtgc cactactgcg gcgcacacgg ttcggcagcc
    13501 atatatgccg gaaaaggcag aaagctgggt gatccgttgg tcaaatttcc aacggcaaca
    13561 ggtagcaact ccagttgtcc gcccactgaa aagccgcacg gcgacccaga gcaaggggca
    13621 ctcacacaga agcaaattga atggtgtcgt gacgtccgcc acattccgcc ggaagtattg
    13681 gtggaagctg gcgtggcttt cgcctccatc tcgatgccta tatccggaaa ggagaaaggc
    13741 tgggaaaaga gggactgtct ctgcttcaac tttttcgaaa acggggaatt ggtgaacacg
    13801 aagttccgcg actcacaaaa gcacttcaaa ttactgcaag gagcgcgcac catcccttac
    13861 aacatcgacg ccatccgcga cacgccggag tgcatcctcg tggaagggga atttgatgcc
    13921 ctctcctaca tggctgtcgg ccggacggat gtcatttccg tgccgaacgg tgccaacagt
    13981 caactggact ggctggacga attgtcggaa tctcatttcg agcagaaaca agtgatttat
    14041 ctgtcggtgg acaccgaccg caagggacgg gaactgtgcc gggaactctc ccgacggctg
    14101 ggggtagacc gctgccgtat cgtcacctac ggcgaagcat acaaggacgc caacgaactg
    14161 ctcgtggcgg aaggcccgga cgcactactg aaggcactgg aggacgcacc catcccccgc
    14221 ctggaaggta cgtttacggc agaagactta cgggagcggt tgcaccaact gtttgaagag
    14281 gggtatactt cgggcgtgga attgggaata ccgaatctgg acgaaatcat gaggctggaa
    14341 acggggcggg tgctcaccgt caccggtatt cccggacatg gcaaatcgga ctttgtagat
    14401 gagatagtgc tccggctctg cacccgccaa gattggcgag cgggatattt cagtccggag
    14461 aacacgccaa tcgagtatca tcatgccaaa ctggcggaga aactgctggg acaccgtttc
    14521 cgcaaagatt tctctacgga ggaggaattc gcccgcgtag tggattatct t
//
