LOCUS       c00674_gnlPro..        14324 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KHLFNIBO_674.
ACCESSION   c00674_gnlPro..
VERSION     c00674_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 15:54:10
            Original ID  :: gnl|Prokka|KHLFNIBO_674
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14324
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1383)
                     /locus_tag="ctg674_1"
                     /transl_table=11
                     /translation="MILNKILSWNKLSILGISLMLLNNISCIDYEDNVNPNEVTEEMME
                     VDNLKTGAFFSQMLRRVVIINDGDKLDSDYQIAQNLSHDLYSGYIAATLGSTNHNGQYN
                     FQEQWVNATFDYAYTGIMAPWQSIHKIATEQELPEVDALATIVKVEGMHRIADTFGPIP
                     YVNYGSSSLYDALDLVYNKFFEELDNAIEVLSNYVNGNVDAKLMSDYDCVYGGDVEKWV
                     KFANTLRLRLAIRVSYANPTLAEAQAKKSMENMFGFIESKAERAELSHNSLEYHHPLHE
                     IAYNFNSGDCRPGATIVAYLNGLNDSRISSYFTAADDGEYHGVRIGITTSNMSNYQGNK
                     ISNLNINRASTPVVWMTAAESFFLRAEGALRGWDMGGTAKSFYEQGVRMSFEENNAAGV
                     DDYLADHTSTPGAFADNVGSDNYTFSSRVTPAWDDNAGFEAQLERIITQKWIANYPDGP
                     EGW"
     protocluster    1..14324
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8779:13636]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8780..13636
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14324
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14324
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(1408..4707)
                     /locus_tag="ctg674_2"
                     /transl_table=11
                     /translation="MRISLALLFAVVLQLSAENGYAQRTHVAISMNNVSVEQVLNKIEE
                     ASDYVFLYNDKTIQKNRIVSVRNKSGKILDILDDIFKGTDITYTVVDKQIILSTNKMQL
                     VQQEGQIQIKGVVKDAGGDPLIGVNVKVKDSTVGTITDINGNFTLQTRKGDILEISYVG
                     YATKTVKVQNAQVLNIVLTEDTEVLNEVVVTALGIKKEAKSLSYNVQQVSNAEITRIAD
                     ANFVNNLNGKVAGVTINSSSAGVGGSSRVVMRGTKSLNGNNNALYVVDGIPMSDMSAAS
                     TQPTDSYEGAGQSGDPISGLNPEDIESISVLSGPSAAALYGSAAANGVVMITTKKGREG
                     RTSVSISNNTTFSAPLVLPEFQNTYGQTEVGSYYSWGSKLNTPSSYDPKDFFQTGVNVT
                     NAASLSTGTDKNQTYLSLGTTNAKGIIHNNDYERYNVTVRNVAKMLKDKLTLDLSFMLS
                     SVKEQNMTSQGLYYNPLVPLYLFPAGDDFSKVQAYQRYDSERNLLTQYWPYSTSLALQN
                     PYWITEHIKIPNHKNRYMATASAKYEFADWINVTARAKMDRNNERRERMYDAGTNTLFA
                     SKYGYYSKSNIENQQIYGELLLNINKYFVDNTLNVTANVGGNFENNDYQSDYFGGKLKS
                     VANLFTFGNVDTSEKNLANQYGYHLKKRAIFGSAQIGYKSMAYLDVTARNDWSSTFKGT
                     NTGSFFYPSIGLSGIITDIFRCSTDIMPYMKVRISYSEVGNSPDVFLAIPTYALVDGVP
                     VTQSRRPNPNLKPERTKSWEAGFNFVFFKNRLRLDGSIYQSRTYNQFFERTLSSTTGYK
                     SEVVNGGRVDNKGIELSLRFEDKWGNFGWSSYLTYSLNRNKVVELLRNYEDPYTHELTS
                     LDRIDMGGTSMYKMILTEGGSIGDIYVNTLRTDEHGAIYVHPSDQVVVTQPDEFVKAGN
                     SAPKYNLGWGNTFSYKGLSLGFLFTARVGGVVVSQTQATMDAYGSSKATAIARDNGGAI
                     VNGRPIGAEDYYTKIGGAGAQGGIGSMYTYSATNVRLAELSLGYDIPINKYVDWIKGLN
                     VSFIGKNLFFLYRKAPFDPELTASTGTYFQGIDMFMSPSLRNLGFSVKVNF"
     CDS             complement(4957..5880)
                     /locus_tag="ctg674_3"
                     /transl_table=11
                     /translation="MENMNPESLLRKAQALGEDIKEMESIDVMGAYQQAQTQIKTNRRR
                     SMYNQLMRYAAFLTIPLLLSSLILGYLYWGATDTEEKYAEVMAATGSVIRYELPDHSVV
                     WLNSGSTLRYPTVFKKDNRNVELKGEAYFEVEADRKRPFYVNTPAGLSVYVYGTKFNVN
                     AYEDDNSIETVLEKGKVNVISPDGKTTVQLAPGERLLYNKVDQKLLKGKVDVYEKVAWK
                     DGKLIFRNAELGEIFKRLARHFNVDIQFNNISGKEYKYRATFRNETLPQILDYLAKSAA
                     LKWRTEEAVQQADDTFTKKKIIVDLY"
     CDS             6105..6674
                     /locus_tag="ctg674_4"
                     /transl_table=11
                     /translation="MKISFSRQTKERAFKQLYEDYYAPFCLYAKRFVDDKEVREDIVSD
                     VFTSLWDKLDTDSFDLQSETALGYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPLYET
                     ETDSVYTLDELYRMLYETLNKLPENYRTVFMKSFFEGKTHAEIAEEMNLSVKSINRYKQ
                     KTMELLRNELKDYLPLFLLFLSPEQL"
     CDS             complement(6648..7754)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 52.9; E-value:
                     7.6e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg674_5"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-17, bitscore:
                     52.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMIFDRQKQRLLLEGKEYTPGDIHSLVAEGEGNHPSAIWDLYLFL
                     NEWFNDDPVITVHTSGSTGAPKELLVRKDQMIQSARLTCEFLDLKQGETALLCMNLRYI
                     GAMMVVVRSLIAGLNLIVRRASGHPLADVDTPLRFAAMVPLQVYNTFQIPEEKEKLKQT
                     EILIIGGGAVDKALEEKIRNLSNAVYSTYGMTETLSHIALRRLNGAAASDRYYPFSSVE
                     LFLSSENTLMINAPLVCDDTLQTNDIARIYPDGSFTILGRKDNVINSGGIKVQAEEIEK
                     LLQSFIPVPFVITSVPDQRLGQAVTLLIEGQMEISALETKLESVLAPYYRPKYIYQVNH
                     IPQTGNGKINRKECRVLAESLQLLGRQE"
     CDS             complement(7751..8776)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg674_6"
                     /sec_met_domain="MR_MLE_C (E-value: 1.8e-29, bitscore:
                     92.5, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCKIDIIPRVLHFKQPAGTSRGTYTTRKVWYLHFTAPEFPNWVG
                     IGECAPLPNLSCDDLPDYEEVLAKICRQVENQGGKLDMEVLCKYPSILFGLETAIRHFF
                     EGSWALWDTPFSRGEAGIPINGLIWMGDFNRMLAQIEKKMEAGFRCIKLKIGAINFEEE
                     LALLQHIRSHYSFKEIELRVDANGAFSPTDAMEKLKRLSELDLHSIEQPIRAGQWEEMA
                     RLTSESPLPIALDEELIGYNTWEEKQRLLSAIRPQYIIIKPSLHGGLAGGEEWIAEAEK
                     LNIGWWITSALESNIGLNAIAQWCATFQNPLPQGLGTGLLFTDNVEMPLEIRKDCLWFC
                     K"
     CDS             complement(8780..9604)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg674_7"
                     /sec_met_domain="ECH_1 (E-value: 2.1e-82, bitscore: 265.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYEDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKKYPKFP"
     CDS             complement(9608..11275)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg674_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.8e-09, bitscore:
                     25.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLEAHGITKVVLCPGSRNAPIVHTLSTHPGFT
                     CYAMTDERSAGYFAIGLALNGGHPAAVCCTSGTALLNLHPAVAEAYYQNIPLVVISADR
                     PAAWIGQMAGQTLPQPGVFQTLVKKSVNLPEIQTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINIPISEPLFQFTVESLPEVRVITRYQGLNVYDRDYNDLIERLNRYQKRMIIVGQMN
                     LIYLFEKRHTKLLYKHFVWLTEHIGNQTVPGIPVKNFDAALYAMPEEKTGQMTPELLIT
                     YGGHVVSKRLKKYLRQHPPKEHWHVSADGEVVDLYGSLTTVIEMDPFEFLEKIAPLLDN
                     RVPEYPRVWENYCKTIPEPEFGYSEMSAIGALIKALPESCALHLANSSVIRYAQLYQVP
                     STIEVCCNRGTSGIEGSLSTAVGYAAGSDKLNFIVIGDLSFFYDMNALWNINVRPNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKYITAVHKTSAKGWAEERGFLYQRVENEEQLAEAM
                     KTFTQPEAMEQPVLMEVFSNKNKDARILKDYYHQLKQK"
     CDS             complement(11295..12407)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg674_9"
                     /sec_met_domain="Chorismate_bind (E-value: 3.2e-58,
                     bitscore: 186.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDEKSNLTTIDALIQRKQPFAVYRVPGEKYPRLLTEDVGAVRLI
                     FDLKELNGQRGFVIAPFRIDKSCPIVLIQSDRTGQPLPMEIVAEEEQDLQSYPEESFHT
                     LCTGKYATCFHTFIEALRDATFDKLVLSRSLTIGKNPEFSPSAVFRAACQRYIHSYIYL
                     CYTPQTGVWLGSTPEIILSGEKNEWNTVALAGTQPLQNGKLPQVWDDKNRQEQDYVASY
                     IRRQLLSLGIRSTESGPYPAYAGALSHLKTDFHFSLKDNKNLGDLLKVLHPTPAVCGLP
                     KEEAYRFILENEGYDRKYYSGFIGWLDPEGRTDLYVNLRCMHIEDEQLTLYAGGGLLAS
                     SELNDEWQETEKKLQTMRRILVSAPIMMNH"
     CDS             complement(12404..13636)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg674_10"
                     /sec_met_domain="HBT (E-value: 2.1e-17, bitscore: 53.0,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKSLELGNYGGYILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNN
                     FALFTYHDDTIITDTPENEHIQNEARLNNLKVIKEEEFSVAIDFAPCKCMLVSDDEEAL
                     VSLEGHWKRRLNGALDVFRSEPYFLEVVPCAIDKANTLGALLEELDVKREEVIAIGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKVCADYVTASNEEDGVALAVEKAIIAEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALGETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVATIVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             complement(13721..14083)
                     /locus_tag="ctg674_11"
                     /transl_table=11
                     /translation="MVQVRIKRVYEDFSETDGYRVLVDKLWPRGIKKEWLKYDYWAKDI
                     TPSAALRRWFHEDIPGHWNDFVVMYQKELEASQAVADFLTLIKPHPVITLLYASKEPVY
                     NHARILRDYLEMHLKE"
     CDS             complement(14154..14324)
                     /locus_tag="ctg674_12"
                     /transl_table=11
                     /translation="LRINYAIQLLKQHPNYTIRAIADEAGFNSTPILYSMFKKKTGMTP
                     YEFKKTQESLG"
ORIGIN
        1 ccagccttcg ggaccgtcgg gataattggc aatccacttc tgtgtaatga tgcgttccaa
       61 ctgagcttca aatccggcat tatcatccca tgcaggagta accctgctgc tgaaagtata
      121 attatcacta cccacattgt ctgcaaaagc acccggagtc gaagtatgat cagccaaata
      181 atcgtctaca ccggcggcat tattctcctc aaacgacatg cgtacacctt gctcatagaa
      241 tgatttggcc gttccaccca tatcccagcc acgtaatgca ccttcggcac gcaggaagaa
      301 cgattcggca gccgtcatcc atactaccgg agtagaagca cggttaatat tcagattaga
      361 gattttattg ccttgataat tgctcatatt gcttgttgtg ataccaatac gtacgccatg
      421 atattcaccg tcatcggctg ctgtaaaata agagctgatt cgcgaatcat tcagtccgtt
      481 caaataggct acgatggtag cacccggacg acagtcaccc gaattgaagt tataggcaat
      541 ctcgtgcaac ggatgatgat attccaatga attatgcgaa agttcggcac gttccgcttt
      601 actttcgata aagccgaaca tgttttccat cgacttcttt gcctgtgctt ctgccagtgt
      661 gggattcgca tatgaaacac gtatagcaag acgcaaacgc agtgtgttgg cgaacttcac
      721 ccacttctct acgtcccccc catatacaca gtcatagtca ctcatcagct tagcatccac
      781 atttccgttc acataattgc tcaatacttc gatagcatta tccagttctt caaaaaactt
      841 attataaacc aaatccaatg cgtcatataa gctggaagag ccatagttta catatggaat
      901 aggaccaaat gtatcagcaa tacggtgcat gccttctacc tttacgatgg tagccaatgc
      961 gtcaacttcc ggcagttcct gttcagtggc tattttgtga atactttgcc atggtgccat
     1021 aattccggta taggcataat caaaagtggc attcacccat tgttcctgaa agttatactg
     1081 cccgttatga ttggtagatc ctaaggtagc ggcaatatag cccgaataaa ggtcatgcga
     1141 taagttctga gcaatctgat agtcagagtc gagcttgtcg ccatcattta tgattacaac
     1201 ccgacgcagc atttgcgaaa agaaagcacc cgtcttcaag ttgtctactt ccatcatttc
     1261 ctcggtgact tcattcggat ttacgttatc ctcatagtcg atacacgaaa tgttatttaa
     1321 tagcatcaaa gatatcccga gaatggaaag tttgttccat gatagtattt tatttaatat
     1381 catatcttct acaatttata agtttgatta gaaattaact ttcacagaga atcccaaatt
     1441 acgcagactt ggcgacataa acatgtcgat accttgaaag taagtgcctg tacttgctgt
     1501 cagttccgga tcgaacggag cttttctata aaggaaaaag agattcttac cgatgaaaga
     1561 tacgttcaac cccttaatcc agtccacata cttgttgata ggaatatcat agcctaacga
     1621 taactcagcc aaacggacat tagtcgcact gtaggtgtac atagaaccaa taccaccctg
     1681 agcacctgca cctccaattt tcgtatagta atcttccgca ccgattggac gaccgttaac
     1741 aatggctccg ccattatcac gggcaatagc tgtagccttt gaagagccgt atgcgtccat
     1801 cgtcgcctgt gtctgtgata caactacacc accgacacgt gccgtgaaca ggaatcccaa
     1861 tgaaagccct ttgtaactga atgtgtttcc ccaaccgagg ttatacttag gagcactatt
     1921 accagccttt acaaattcat caggctgagt aactacaacc tggtccgaag gatggacata
     1981 gatagctcca tgttcgtccg tgcgaagcgt attcacataa atatcgccga tagatccgcc
     2041 ttctgtcagt atcattttat acatacttgt cccgcccata tcaattctat ccaaagaagt
     2101 aagttcgtgc gtataaggat cttcatagtt gcgcagcaat tccaccactt tatttcggtt
     2161 caatgaatag gtcagatacg aactccagcc aaaatttccc catttgtcct caaaacgcaa
     2221 agacaattcg atacctttat tatctacacg accgccattg actacttccg atttatagcc
     2281 ggtagtagaa gaaagggtac gttcaaagaa ctgattgtag gtacgtgact gatagataga
     2341 tccatccaat ctcaaacggt tcttgaagaa gacaaagtta aatccggctt cccatgattt
     2401 ggtacgttcc ggcttcagat tggggttagg acgtcgggac tgagtaacag gaacgccatc
     2461 aaccaacgca taagtcggaa tagccagaaa tacatccggt gaattaccta cttccgaata
     2521 agaaatacgt actttcatgt atggcataat atccgtactg caacggaata tatctgtgat
     2581 aatccccgaa agaccgatag acggatagaa gaaagaaccg gtattcgtcc ctttgaaggt
     2641 agatgaccag tcgttacgag ccgtcacatc cagataagcc atagacttgt aaccgatctg
     2701 agcactaccg aatatggcgc gttttttcaa atgatagcca tattggttgg ccagattctt
     2761 ctctgaagta tccacgttgc caaaagtaaa gaggttggct accgacttca gtttgcctcc
     2821 gaaataatca gactgataat cattgttttc aaagttccca cccacattag ctgttacatt
     2881 tagggtatta tcgacaaagt acttattaat attcagcaat aattcaccgt atatctgttg
     2941 attctcgata ttactcttgg agtaataacc gtatttagaa gcaaacaaag tatttgttcc
     3001 ggcatcatac atgcgctcac ggcgttcgtt gttgcggtcc attttggcac gggctgttac
     3061 attaatccag tcagcaaatt catattttgc cgatgcagtt gccatataac ggttcttatg
     3121 attaggtatt ttaatatgct cggtaatcca gtatggattc tgtaaagcca gacttgtgct
     3181 gtaaggccag tactgagtca gtaaatttcg ttccgaatca taccgctgat atgcctgtac
     3241 tttggagaaa tcatctcccg caggaaatag ataaagaggt actaacgggt tataataaag
     3301 tccctgagag gtcatatttt gttcttttac agagctaagc ataaaactca ggtcaagagt
     3361 cagcttatct ttcagcatct tggcaacatt acggacagtg acattgtaac gttcgtagtc
     3421 attattatgg ataatacctt tggcattggt agtacctaaa gataagtaag tctgattctt
     3481 gtcagtacct gtagaaagac tggcagcatt tgttacattc acacctgtct gaaagaagtc
     3541 tttaggatca tagctgctcg gcgtattcaa tttactgccc cagctgtagt aactacccac
     3601 ttctgtctgc ccataagtat tttgaaattc gggcaagaca agaggagcgg agaaagtcgt
     3661 attattggat atgctgactg aagtacgtcc ttccctacct tttttagtag taatcatcac
     3721 aacaccattg gcagcggcac taccgtaaag agctgcagct gacggtccac tcaaaacaga
     3781 gatactctct atatcctcgg gattcagacc ggaaatagga tcaccggact gaccggcacc
     3841 ttcgtatgag tccgtaggct gtgtagaagc ggcactcata tcactcatcg ggataccatc
     3901 aaccacataa agagcattgt tattaccatt caatgatttg gttccacgca tcactacacg
     3961 tgaagagcca ccgacaccag ctgaagatga gttaattgta acacccgcaa ctttaccgtt
     4021 cagattattg acgaagttgg catctgcaat gcgtgtaatc tcggcattgc ttacttgctg
     4081 tacattgtat gacaaagatt tagcttcctt cttgataccc aatgcagtaa caacgacttc
     4141 attcagtact tctgtatctt ctgtcagcac aatattcaga acttgggcat tctgtacctt
     4201 tactgttttc gtggcatatc ccacataaga aatttccaga atatctcctt tcctggtctg
     4261 tagcgtaaag tttccgttta tatcggtgat agtaccgacc gtagaatctt tcactttcac
     4321 attcacaccg atcaagggat ctccgccagc atctttcaca actcctttta tttggatttg
     4381 tccttcctgc tgaacaagtt gcattttatt agtcgataaa ataatctgct tgtcaactac
     4441 ggtatacgta atatcggtcc ccttaaaaat atcatctaga atatccagaa tcttacctga
     4501 tttatttctc acagaaacaa tacgattctt ctgaatcgtt ttgtcattgt aaaggaaaac
     4561 ataatcggaa gcttcttcta ttttattcag tacctgttct acagatacat tgttcataga
     4621 aatggcaaca tgcgtccgtt gagcatagcc attctctgca gatagttgta aaacgactgc
     4681 aaaaagtagt gccagactaa tcctcataac taaaggtagt tttagattta aagcatattt
     4741 aggatataat gcaataaatg aatgattttt tttcatacat ttgcggttaa ctaaagttta
     4801 ttactataat gaactgtggt ttgattccgg ttagcgtttg caagactcct taccgcgaat
     4861 ctgaaaaatt gggggaagac agctgttggt agcagctttc ttcctttttt tacgatcttt
     4921 gtgttatctc ataggctatt ctcattttta tggttactaa tataaatcta ctattatctt
     4981 tttctttgtg aatgtatcat ctgcctgttg taccgcctcc tcagttctcc acttcaaggc
     5041 agcagactta gccagataat ccaatatctg tggcagtgtt tcattacgga aggtcgcacg
     5101 atatttatat tcttttcccg atatattatt aaactgaata tctacattaa aatgccgtgc
     5161 cagccgtttg aatatttcac ccaactcggc attgcggaat atcaacttac cgtctttcca
     5221 tgccaccttt tcataaacat ccacttttcc cttcaacaat ttctgatcta ccttattata
     5281 aagcaatcgt tctcctggag ctaactgaac tgttgttttt ccgtccggtg aaataacgtt
     5341 tactttaccc ttttctaata ccgtttctat actattatca tcttcgtaag cattcacatt
     5401 aaatttggtt ccgtacacat agacacttaa cccggcagga gtattgacgt aaaaaggccg
     5461 tttcctgtcc gcttctactt caaaataggc ttcacctttt aattcaacat tacgattatc
     5521 tttcttaaaa acggtaggat aacgtaaagt actaccggag tttaaccaga caaccgaatg
     5581 gtcaggaagt tcgtaacgaa tgactgaacc tgtagccgcc atgacttctg catacttctc
     5641 ttcagtatcc gttgctcccc aatataaata tcccaaaatc aaagaagaaa gtaataaagg
     5701 tatagtcaag aatgcagcat aacgcatcaa ctgattatac atactccttc ttctgtttgt
     5761 ctttatttgg gtctgtgctt gttgataggc acccattaca tcaatagact ccatttcctt
     5821 aatatcctct cctaatgcct gcgcttttcg gagcaatgat tccggattca tattttccat
     5881 attctctttc aaaatcttat cttttaattg caattacact aatagtacaa ctgaggtaat
     5941 cgaaaaggga caggtataac atactttttt ttattttatt ttttaagcta tcttattttc
     6001 cacagcttca taccaaaaac aaaaaaagaa agaaaatttt aggaaatgct gattttctta
     6061 ttatatattt gcagtaaaat gaaaaactac agaatctcaa aataatgaaa atatcttttt
     6121 ccagacagac taaagaaaga gctttcaaac aactttacga ggattattat gcccctttct
     6181 gcctgtatgc aaaaagattt gtagatgata aagaagtccg cgaggacatt gtttcggatg
     6241 tattcacctc cctatgggac aagttggata ccgactcttt cgatttgcaa tcagagacag
     6301 cattgggata tataaaaatg tgtgtaaaaa acagctgttt gaactttctg aaacatcagg
     6361 agtatgaatg gagttatgcc gaaaatatcc aaaagaaagc tcctctatat gaaacagaaa
     6421 cagatagtgt atatacactt gatgagttat accgaatgct atacgaaaca ttaaataagc
     6481 ttccggaaaa ctatcgcacc gtatttatga agagtttctt tgaaggcaaa acacatgcgg
     6541 aaattgccga agaaatgaat ctcagcgtaa aatccattaa tcggtataaa caaaaaacaa
     6601 tggaactcct gcggaacgag ttgaaagatt acctcccgct atttttatta ttcctgtctc
     6661 ccgagcaact gtaagctctc tgctaaaaca cggcactctt tacgattaat cttcccattt
     6721 cccgtttgag gaatatgatt tacctgataa atatatttag gacgataata aggtgctaag
     6781 actgattcca atttagtctc tagcgcactt atttccatct gcccttctat caataaagta
     6841 acagcctgcc ccaaacgttg atccggaacg gaagtgatta caaacgggac aggaataaac
     6901 gactgaagta acttttcgat ctcttctgcc tgcactttaa ttcctccgct attgattaca
     6961 ttatcctttc ttcccagaat cgtaaaacta ccgtccggat aaatgcgggc aatatcattt
     7021 gtctgcagag tatcatcgca gacaagcgga gcattaatca tcaaagtatt ttctgaagac
     7081 aaaaacaact ctacggatga aaaaggataa taacgatcgg atgctgctgc gccattcaga
     7141 cggcgaagag cgatgtgaga aagggtttcc gtcatcccgt aagttgaata aacagcattg
     7201 gacagatttc tgattttttc ctctaaagcc ttgtcaactg ctccgcctcc tataattaaa
     7261 atctccgttt gctttaattt ctctttctct tcgggtatct gaaatgtatt atacacctgc
     7321 aaaggcacca tagccgcaaa ccttaaagga gtgtccacat ctgccaatgg atgaccggaa
     7381 gcccgacgta ctataagatt caacccggca atcaaagaac ggacgactac catcatcgcc
     7441 ccgatatagc gaaggttcat acacaataat gccgtttcac cctgctttaa atccagaaac
     7501 tcacaagtca ggcgtgcact ctgtatcatc tgatctttgc gaacaagcaa ttctttaggt
     7561 gcccccgtag aaccggaagt atgtacagtg atcacaggat catcattaaa ccattcgttt
     7621 agaaaaagat acaagtccca tatagcagaa gggtggtttc cctcaccttc tgctacaagg
     7681 ctatgtatat cgcccggagt atattccttt ccctccagca acaaacgctg tttttgtcgg
     7741 tcgaatatca tcatttacaa aaccacaaac aatcttttct gatttcaaga ggcatctcta
     7801 cattatctgt aaagagtaac ccggtgccta acccttgcgg caatggattc tgaaaagtag
     7861 cacaccattg agcgatagca ttcagaccga tattagactc cagagcagaa gttatccacc
     7921 aaccgatatt cagtttctcc gcttctgcaa tccactcctc gccaccggct aatccgccat
     7981 gaagagaagg tttgataata atatattgcg gacggatagc cgaaagtaat ctttgctttt
     8041 cttcccaggt attatagcct atcagttcct catccaaagc tatcggcaaa ggagattcgg
     8101 aagtaagacg tgccatttct tcccattgtc cggcacgaat gggctgttct atcgaatgta
     8161 agtccagttc ggacaagcgt ttcaatttct ccatcgcatc tgttggcgag aatgctccgt
     8221 tggcatctac acgcaattct atttctttaa aagaatagtg agagcggata tgttggagta
     8281 aagccagttc ttcttcaaag ttgatggcac cgatcttcaa ctttatacag cggaatcccg
     8341 cctccatctt cttctctatc tgagcaagca ttctattgaa gtcacccatc cagataagcc
     8401 cgtttatcgg aatacctgct tccccacgtg agaagggtgt atcccacaaa gcccagcttc
     8461 cttcaaaaaa gtgacgaatg gctgtctcca agccaaaaag gatggaaggg tacttgcata
     8521 gaacttccat gtccagctta cctccctgat tctctacctg ccggcagatt ttagccagca
     8581 cttcctcgta atcgggaaga tcatcacagc taagatttgg cagaggagcg cactccccga
     8641 tccctaccca attgggaaat tcgggagcag taaaatgaag ataccagact tttcgcgttg
     8701 tgtatgtgcc tcgtgaagtt ccggccggct gcttgaaatg aagcacccgc ggaataatgt
     8761 ctattttgca atccattgtt taagggaact tcggatattt cttaaagtta ggtttacgtt
     8821 tctccagaaa tgcattcttt ccttcctgag cctcatccgt cagatagtaa agcaaggtcg
     8881 catcccctgc cagctcctga atacctgcct ggccgtccag ttcggcattc aatccggctt
     8941 taatcatccg caaggccaac ggactgagca gcatcatttc ttccgcccat tgcacatact
     9001 catcctccag ttgctccaat ggaactactt tattcaccaa tcccatatcc aacgcttcct
     9061 gcgcattgta tttccggcaa aggaaccata tctcacgtgc cttcttctga ccgacgacac
     9121 gagccagata agaggctccg aaacctgcat caaagctacc tacgcgagga ccggtctgtc
     9181 cgaagatcgc attctccgaa gcaatcgata aatcgcaaac tacatgaagc acgtgtccgc
     9241 caccaatggc aaatccattt acggcagcaa ttaccggttt cggaatgctg cggatttgtt
     9301 tctgtacatc cagaacactc agacggggaa caccgtcctt gccgatatag ccgccacgcc
     9361 ctttcacatt ctggtcaccg cccgaacaga aagccttgtc accagctccc gtaatcacga
     9421 tcacatcaat atccgcttct tcccggcaaa tgcgcaatgc gtcactcatt tcagccgttg
     9481 tagtcggagt aaatgcattt cgatagcgtt cacggttaat ggtgatgcgg gcaatcccat
     9541 tatagtaatc aaagaggata tcttcgtatt ctctgatggt tgtccattct ctttgtgttg
     9601 acataatcta tttttgtttt agttgatgat aataatcttt cagtatacgt gcatctttat
     9661 ttttattgct gaatacttcc atcagaaccg gttgttccat ggcttccggt tgtgtgaagg
     9721 ttttcatcgc ttcggcaagc tgttcttcat tctctacccg ttgataaagg aatccgcgtt
     9781 cttccgccca tcctttggca gatgtcttgt gaacggctgt aatatacttg tgcgatgtac
     9841 ccgacatatc cagtccgggt aatgtatgga aaatctcccc tcctccgtta ttcagcaaaa
     9901 gaatgcgtag attgggacgg acattgatgt tccacaaagc attcatatca taaaagaaac
     9961 taaggtcacc tataactata aaatttagtt tatccgaacc ggcggcatat cccactgccg
    10021 tggacaacga gccttcgatg ccgcttgtac cccgattaca gcatacctca atcgtagaag
    10081 gaacctggta taactgagca tagcggataa cagaactatt tgccagatgc aatgcacatg
    10141 attccggcaa tgcttttatc aaagcaccga tagccgacat ttccgaatat ccgaactccg
    10201 gttcgggaat ggtcttgcaa taattctccc atacacgggg atactccggc acgcggttat
    10261 ccagcaatgg agctattttc tccagaaact caaacgggtc catttcgatg acggtagtca
    10321 gagaaccgta aaggtcaacc acttctccat cagcagacac atgccaatgt tctttaggcg
    10381 gatgctgccg aagatatttt ttcaaccgct tggaaaccac atgtccgcca taagtaatca
    10441 ataactcggg agtcatctgg ccggttttct cttcgggcat cgcataaagc gccgcatcaa
    10501 aattcttcac tggaataccg ggtactgtct gattaccgat atgctcggtc agccacacga
    10561 aatgtttata taacaatttg gtatgccgtt tctcaaacaa gtaaatcaag ttcatctgtc
    10621 cgacaataat catccgcttc tgatatctgt tcaagcgttc gatcaggtca ttgtaatccc
    10681 ggtcgtatac attcagcccc tgatagcgcg taatgacacg tacttcggga agcgactcca
    10741 ccgtaaactg gaacaaaggt tcggatatag gaatattaat atgtaccgga ccttttccat
    10801 gatggttggt ttccagcaag gcttcattca ccaagcggtt acagtaccat tcatcctctt
    10861 ctgtctgaat ctccggaagg tttaccgact tcttcaccaa tgtctgaaaa acaccgggct
    10921 gcggcaatgt ctgtcccgcc atctgtccaa tccaggcagc aggccgatcg gcagagataa
    10981 caactaaagg tatattctga taatacgctt ctgccacagc aggatgaaga ttgagcaacg
    11041 ctgtaccgga agtacagcaa acggcagcag gatgcccgcc attcagcgca agaccaatcg
    11101 caaaataacc ggcactccgt tcatccgtca tagcataaca agtaaaaccc ggatgagtag
    11161 acagcgtatg cacaataggt gcattacggc taccgggaca taacactact ttcgtaattc
    11221 catgcgcctc aagcagcgcg accaactgga gtatattttt cttgtccgaa tacatattga
    11281 tagtgattag cttgttagtg attcatcatt attggagcag acacaagaat acgcctcatg
    11341 gtctgcaatt tcttttccgt ttcctgccat tcatcattca actctgaaga ggctaacaat
    11401 ccgccaccgg catacagtgt caattgctcg tcttcaatgt gcatgcaacg cagattcaca
    11461 tacaaatctg tgcgtccctc cggatcgagc caaccgataa aaccggaata atacttacga
    11521 tcgtaccctt cattttccaa aatgaaccgg taggcttctt ctttaggcag tccgcacacg
    11581 gcaggagtcg gatgcaggac tttcagaagg tctcccagat ttttattatc tttcaaagag
    11641 aaatggaaat cagttttcag atgtgacaag gcaccggcat aagccggata aggtccgctc
    11701 tctgtggagc gaatgcccag cgaaagaagc tgccgacgga tataggacgc cacataatcc
    11761 tgctcctgac ggtttttgtc atcccatact tgcggaagtt taccattctg caaaggttga
    11821 gttcctgcca gggcaactgt gttccattca tttttttcgc ccgacaatat aatttcgggg
    11881 gtacttccca gccacacgcc cgtctgagga gtataacaca gatagatata ggaatgaata
    11941 taacgttgac aagctgcacg aaaaacagct gaaggggaaa actccggatt ctttccaata
    12001 gtgagactac gggaaagcac cagtttatca aaggtagcat cacgcaaggc ttcaataaat
    12061 gtatgaaaac aggtcgcata cttcccagta caaagggtat gaaaagattc ctccggataa
    12121 ctttgcaagt cctgctcttc ctctgccacg atttccatag gcaacggttg tccagtcctg
    12181 tcggactgta tcaacacaat cggacatgac ttatctatac ggaacggagc aatcacaaat
    12241 cctctttgtc cattcagttc tttcaaatcg aaaatcaagc ggacagctcc gacatcttct
    12301 gtcaacagac gaggatactt ctccccggga acacgataaa cagcaaaggg ctgtttccgc
    12361 tgaataagtg catcaatagt tgtcaagtta cttttttcgt caatcatctt tttttcatca
    12421 cactgttgac cacccgtata gaggacacca gtttattggt tgaagtaaaa acgtccacat
    12481 tccatacatg ggaggaacgt cctttgtgta caatcgtcgc tactgcacgt actgtatcac
    12541 cttcgtgcgc agaagatata tgatttccgc tgacctgcat tcctaccaca atttcatccg
    12601 gctgacagag aatcatcgag ccgagtccgg caactgtttc tcccaatgca agcgtagctc
    12661 caccgtgcaa aataccgaac ggctgacggg tacggtgatc taccggcatc gtcgcctcta
    12721 cacggtcttc gtcggcatat gtatattgga tacccagatt acccatcaat gcgtgacgcg
    12781 cctgtgcatt caactggtcc aaaggaatct ctgcagcgcg aacttccgct attatcgcct
    12841 tttcgacagc cagagccact ccgtcttcct cattggaagc tgtcacataa tccgcacaga
    12901 cctttaccga atcctgcgaa tgccccatcg ccactcccag tcctgccagc tgaatcatcg
    12961 ttacatcgca cacaccgtct cctatagcga tgacttcttc acgcttcaca tccagttctt
    13021 ccaataaagc tcccaatgtg ttggctttat caatcgcaca cggcactact tccagaaaat
    13081 aaggttcgga acggaaaaca tccaaagctc cgttcaaccg tctcttccag tgtccttcca
    13141 gactaaccaa cgcttcctcg tcatcgctga caagcataca cttacacgga gcaaagtcaa
    13201 ttgctacaga aaattcctct tccttgatca ctttcaaatt attcaagcga gcttcattct
    13261 ggatatgttc attctccgga gtgtcagtaa tgatcgtatc atcatggtaa gtgaacagtg
    13321 cgaaattatt ttttcttgcc ttcttttcca gataaggcaa catttccgga ttaatcctcc
    13381 gctcaaacag tatttctccg ttttgagcat taattatctg gcaaccatta taagaaagga
    13441 tataacctcc ataatttccg agttctaggg atttggctaa aggcatcaga ccgtaagtcg
    13501 gtcggccgga tgccaacacg atacgtactc ccatctgctg aactttcagc aaagcagcca
    13561 atgtacgttt actaatttct tttgcatcat tgagaagcgt tccgtctaca tcaagaacta
    13621 ataatttata cttcatggac acacgatttt gatttagatt acaaaggtag gaaattgagt
    13681 gaacgactga aagcggaaag agataaaaat tactttaatt tcactctttc agatgcattt
    13741 ccaaataatc acgaaggatt cgggcatgat tataaaccgg ttctttggat gcataaagca
    13801 aagtgatcac cggatgaggt ttgataagag tcagaaaatc ggcaacagct tgagaagctt
    13861 ccagttcctt ctgatacatt acgacaaaat cattccagtg acccggaata tcttcatgaa
    13921 accatctgcg cagtgctgcg gaaggcgtta tatcttttgc ccagtaatca tatttcaacc
    13981 attctttttt gattccacgt ggccagagtt tatctaccag cacccgatat ccgtcggtct
    14041 ctgaaaagtc ttcgtacact cgctttatcc taacttgcac catttccgtt tatatttagt
    14101 tatcataaga ataaaccgat aaaacggaaa attgtttatc gaaaaagcca aaatcaacct
    14161 aaggattcct gcgttttttt aaattcgtaa ggagtcatac cagtcttttt cttgaacata
    14221 ctgtacagaa taggcgtact attaaatccg gcttcatcag ctatcgcacg aatggtataa
    14281 ttgggatgtt gcttcaataa ctgaatcgca tagttaatac gaag
//
