LOCUS       gnlProkkaCKFEMOPI_64   10598 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CKFEMOPI_64.
ACCESSION   gnlProkkaCKFEMOPI_64
VERSION     gnlProkkaCKFEMOPI_64
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 12:25:46
            Original ID  :: gnl|Prokka|CKFEMOPI_64
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 3152
            Orig. end    :: 13750
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10598
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:9314]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10598
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10598
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(805..1794)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg64_6"
                     /sec_met_domain="Glycos_transf_2 (E-value: 7.5e-36,
                     bitscore: 113.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVEEIKVSVIVPIYKVEKYIERCARSLFEQTLTGIEFIFVNDCS
                     PDRSLLILKRIIDEYVDRSLVIRIIEHEKNMGLAVARTTGLNQAKGEYIIHCDSDDWIE
                     TDMYEEMYMKALKEDADIIICDYYAEYQNKHIYHFEEEEENSEFYLKKILNGSLHNGVW
                     NKLIKKEVYERLSFYYKEGVNMWEDVSIIPRLFFFAEKIVSIHKAFYHYSQVNINAYTQ
                     SWKPSSLENIIDAVDIVDSFFKEMNTCKYDTDLLYLKLRAKYSLLLHSSTKQRRVYLAI
                     YPEVDTLIFRHPALSFYDKIIMWCWSNSFNWGALIILCALSCMKKILR"
     CDS             complement(1871..2662)
                     /locus_tag="ctg64_7"
                     /transl_table=11
                     /translation="MTQEELRQKYNPDGSILRCEQLRMLDMLLYLDNVCRKNGLCYWLG
                     SGTLLGAVRHGGFIPWDDDLDIDMLRDDYDKLIRVLMNEQNCPYDLQITSTDSHFVSAY
                     AKLRDRNSLIVENGNVRKYKYNGIFVDIFPISQSYKWMADLMGGLNWRLAKLGRKKNNI
                     WNKIIFWGGKLLYYTLLKILKGVISLCPRVPYRLEMGCGYSKNIRFIEKIFPLSTVKFE
                     GYDFFAPADTNYYLTTLYGKEYMQLPDLSKIVTHISHIELY"
     CDS             complement(2659..3915)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg64_8"
                     /sec_met_domain="Polysacc_synt (E-value: 2.7e-46, bitscore:
                     148.1, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWGYLSRKLQSYKTVIQNTGYLLIIEIIRLALPFVALPYVIHTIG
                     AEKYGTIVFVQTIIQYFVILINFGLDISAVKEVSMNRDNKKLLNEIVSSVLIIKTLLWV
                     TSLLILLVGIIVIPFWRDHALLFFLVFLTCLSELLFPVWFFQGIEKMKYLPIVRTCSIL
                     FYTITVFIFVKSAADYVWVAFLQSIGSFLSGIIAFFLLLRVEKVKLLFPNIRMIHRLFV
                     ESIPFFISRVSNVLNLNMAKTVSGIFFTMDAVAAFDLAQRIAQVSLVPAQMLNQAVYPH
                     IAKTQNRKFANNFLYCNITIAFLVALIIYFLAPFAVYYFAGNTMSEAITLLRILTLFIF
                     CGCITTYLGTPVLVSFGYPKPFNMSVILSTVILLFLYVIIYTFHLFSIEYFALTLFVTE
                     LAILFYRLYYCFHYKIFKL"
     CDS             complement(3922..4839)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158:ornithine cyclodeaminase (Score: 102.2; E-value:
                     4.1e-31)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg64_9"
                     /transl_table=11
                     /translation="MIISTKEIESLGISPKTCVEWVIRSFMMKDTAQLPAKMPVHPVGN
                     DFFTTMPCLLPSDMKRFGVKVVSRILGREPALKSDLLLYDSSNGDLLALLSADWITSMR
                     TGATAALAIKTFRRSKVSKYSFIGLGATAKATVKCLLDYFPNEYFNICLFRYKEQAEQF
                     VSYFGKNNRVSFSIVDTMEDLLKDAGVLVSCVTEAHELLVKDNSLFEPGILVVPVHTRG
                     FQNCDLFFDKVYADDTDHVKGFRYFSAFHHFDEISNVIAQKSVGRENDFERILSYNVGL
                     GLHDVYFASHVYDMLNTDSIGKCL"
     CDS             complement(5001..6122)
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 3.4e-34.
                     Score: 110.2. Matches aSDomain:
                     nrpspksdomains_ctg64_10_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.9; E-value:
                     2.4e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_10"
                     /sec_met_domain="Aminotran_5 (E-value: 3.5e-31, bitscore:
                     98.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPENKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGDIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKVSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        complement(5025..6032)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg64_10_Aminotran_5.1"
                     /evalue="3.40E-34"
                     /label="ctg64_10_Aminotran_5.1"
                     /locus_tag="ctg64_10"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.2"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPENKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGDIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKVSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             complement(6132..7256)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 57.1;
                     E-value: 2.3e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_11"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.1e-20, bitscore:
                     62.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKG
                     HGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             complement(7273..8574)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_12"
                     /sec_met_domain="CTP_transf_like (E-value: 2.1e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.1e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             complement(8595..9314)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.7; E-value:
                     3.4e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_13"
                     /sec_met_domain="NTP_transf_3 (E-value: 7.4e-17, bitscore:
                     52.0, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTEYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             complement(9378..10526)
                     /locus_tag="ctg64_14"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLESYLDEESSPWWDYLIGFPGMVIGGVK
                     SLFGEDTVPAGGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRTEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
ORIGIN
        1 catattgaca agaatatgta aatatggatg tatttgattc tgctttgcat atagcgatag
       61 aataaatatt ccaaacaaat tatagaaaag cctaagcact ccactactaa cacctgaatc
      121 aaaatcctct acaccatatt gatagtaacc aatctccgta aaagaaggca tgatatattc
      181 aacaattaaa ttaaataata tttttccata aaaagcactc acaaacaaag tgattatcaa
      241 caaccaaact ggatatttaa aacggcttat ccaaataagc ggcaaaataa ctaaaacact
      301 gtaatgaaat aatattgcac acaaaacaca taagaaatat tttctacttt tcttttctac
      361 aaaataagaa aatgagacaa ataatagaga taccgctaca tattgccgta caatattcat
      421 agactcaaaa taaaatccac ataatacaaa aagtaaaata gaaatataaa agtgaaaaga
      481 catcttgcga attccaatat aaaatcccca cacaactaac catgaagtca aaaagaagaa
      541 cactcgtact cccatcccta aagcacgcaa cactttattt attcctagcc aaataggttc
      601 aatagccaaa gcatgtaccg aataaggatc gttaaaaata tcctcatata tagggtaatc
      661 tactcctaca ttataacgta atccagcaaa tactaccaat aaaaacaaaa taaattcttt
      721 gaagtaagga aatcgtattt tcattctttc caaacaccaa gttcctaaaa ttatacatat
      781 aagaatgatg ataatcccaa ccatctacct taatattttt ttcatacaac taagagcaca
      841 gagaataatc aaagctcccc aattaaagga attactccaa caccacatta ttattttatc
      901 ataaaaagac agagctggat gtctaaaaat taaagtatca acctctggat agatagctaa
      961 atatactctt ctttgtttcg ttgaagaatg caataacaaa ctatacttcg ctctcaattt
     1021 cagatatagt aaatcagtat catacttaca agtattcatt tctttaaaaa aagaatcaac
     1081 aatatctacc gcatcaatta tattttctaa agaagatggt ttccaacttt gagtataagc
     1141 attaatatta acttgtgaat aatgataaaa agctttatgt atagacacta ttttctccgc
     1201 aaagaagaac aaacgtggta taatggatac atcttcccac atattgactc cttctttata
     1261 atagaaagac aatctttcat acacctcctt ttttattagt ttattccaaa ccccattatg
     1321 taaacttcca ttcaatatct ttttcaaata aaattctgaa ttttcctctt cttcttcaaa
     1381 gtgataaatg tgcttatttt gatattctgc ataataatcg caaataataa tatctgcatc
     1441 ttcttttaat gctttcatgt acatttcctc atacatatca gtttctatcc agtcatcact
     1501 atcgcaatgt ataatatact ctccttttgc ttgattcaaa cctgttgttc tcgcaacagc
     1561 tagccccata ttcttttcat gttcaattat tcttattact aaactacggt caacatattc
     1621 gtctataatt cgttttaaga tcagtaaact tctgtcagga gaacaatcat tcacaaatat
     1681 aaactcaata ccagtcaaag tttgttcaaa aagtgaacga gcgcaacgtt caatatattt
     1741 ttctacttta taaattggaa caatcacact tactttaatt tcttccaccc gcattttata
     1801 ctttctatta accaataaaa taatctacaa ttaaatcaac ttcaataaca ttcattatca
     1861 tttacattct ctaataaagt tcaatgtgtg aaatatgagt tactattttt gaaagatctg
     1921 gtaactgcat atattcttta ccatataaag tagtaagata ataatttgta tcagcaggag
     1981 caaaaaaatc atatccctca aatttgacag tagataaagg aaatatcttc tctataaatc
     2041 ttatgttttt agaataacca catcccattt ctaaccggta aggtacccga ggacaaagag
     2101 agataacccc ctttaatatt ttcaataaag tataatataa caatttccca ccccaaaaaa
     2161 tgattttatt ccatatatta ttcttttttc tgcccaattt agctaaacgc caattaagcc
     2221 cccccataag atcagccatc cacttataag attgagaaat aggaaaaata tcaacaaaga
     2281 ttccattata tttatatttc ctaacattac cattttctac aatcaatgaa ttgcgatcac
     2341 gtagttttgc ataagctgaa acaaaatgag aatctgtact tgttatctgc aaatcatatg
     2401 gacagttttg ttcattcatc aacactcgta ttaatttatc ataatcatcc ctcagcatat
     2461 caatatccaa atcatcatcc caaggtataa atccaccatg tcgaactgcg cctagtaaag
     2521 ttcctgaacc aagccaatag caaagtccat tttttctaca tacattatct aaataaagta
     2581 acatatcaag cattcttagc tgctcacacc gcaatataga accatccgga ttatatttct
     2641 gcctaagttc ttcctgagtc ataatttaaa tattttataa tgaaaacaat aatacaaacg
     2701 ataaaaaaga atagccagtt ctgtcacaaa tagtgtcaat gcaaaatatt caatagaaaa
     2761 caaatgaaaa gtataaataa taacataaag aaataacaag attaccgttg ataatatcac
     2821 actcatattg aatggttttg gataaccaaa agagaccaac acaggtgttc ccaaataggt
     2881 tgtaatgcat ccacaaaaaa taaacaaagt caatattcta agtaaagtta tcgcctctga
     2941 cattgtattt cctgcaaaat agtatactgc aaatggagct aaaaaataaa taattaaagc
     3001 caccaaaaaa gctattgtaa tattacaata caaaaaatta ttagcaaatt tcctattttg
     3061 agttttggca atatgtggat aaacagcttg attcagcatt tgggcgggga ctaatgaaac
     3121 ttgtgctatt cgttgggcca agtcaaaagc tgcaaccgca tccatcgtaa aaaaaatgcc
     3181 actcacagtc ttagccatat ttaaattgag tacatttgaa actctcgaaa taaaaaaagg
     3241 gatactctca acaaaaagtc tatgtatcat acgtatgtta gggaataaca acttcacttt
     3301 ctcaaccctt aacaataaaa agaaagctat tattccagat aaaaagctac ctattgattg
     3361 caaaaaagct acccacacat aatctgctgc tgatttcaca aaaatgaaaa cggtgattgt
     3421 gtaaaataaa atagaacagg tacggacaat aggcaaatac ttcatttttt ctattccctg
     3481 aaaaaaccat actggaaata gcaattcaga cagacaagtt agaaaaacta gaaaaaataa
     3541 aagtgcatga tctctccaaa atggaatcac aataattccc actaataaaa tcaataaaga
     3601 agttacccat aatagtgttt taattatcaa cacagaagaa acaatctcat tcaatagttt
     3661 cttattatca cgattcattg atacctcctt gactgccgat atatctaatc caaaattgat
     3721 taatataaca aaatattgta tgatggtttg gacaaaaaca atagtcccat acttttccgc
     3781 tccaattgta tgaataacat aaggtaatgc aacaaaaggt aatgcaagcc ttattatttc
     3841 gattattaga aggtaacctg tattctgtat tacagtttta taagactgta attttcgaga
     3901 taaataaccc cacattctta tctataaaca tttacctatt gagtctgtat taagcatatc
     3961 ataaacatga gatgcaaaat aaacatcatg taaccctaaa cctacattat atgacaaaat
     4021 acgttcaaag tcattttctc taccaacact cttttgggct ataacattac taatttcatc
     4081 aaaatgatga aaggctgaga aatatctaaa tccttttaca tgatctgtat catcagcata
     4141 taccttatca aaaaataaat cacagttttg gaatcctctt gtatgtacag gaacaactaa
     4201 aatcccaggt tcaaataaag aattatcttt cactaataat tcatgggcct ccgttacaca
     4261 cgatacaagt acaccagcat cttttagcaa atcttccatt gtgtccacta tagaaaaaga
     4321 aaccctatta tttttaccaa aatatgatac aaactgctca gcttgttctt tataacggaa
     4381 caaacaaata ttaaaatact cattaggaaa ataatctagt aaacatttca ctgtagcttt
     4441 agctgtagct cccaatccta taaatgaata tttagaaact ttagaacgac gaaatgtttt
     4501 tatagctaaa gcagcagttg ctcctgtcct catacttgta atccaatctg cagataacaa
     4561 tgctaataaa tctccgtttg aactgtcata caagagtaaa tcacttttta aagcaggctc
     4621 acgtcctaat attcgagaaa caactttgac cccaaaacgt ttcatatcag acggtaatag
     4681 acaaggcata gttgtaaaga aatcattacc gactggatgc acaggcattt tcgcaggaag
     4741 ttgtgcagta tccttcatca taaaacttct tatcacccat tcaacacatg ttttaggaga
     4801 aatacctaag ctctcaattt ccttggttga aataatcatc atattataac atattcttta
     4861 aacaattcaa caatattata ttattttctg tatcctttat cacaattcga atggaactcc
     4921 agaaataaca cttttcgaat ggaagtgtat accacgaagg gaaaaataaa aatgacgaat
     4981 cttcaataat atttctgcaa tcatgacatc ggtaatgtga cgttataatg atttaatgca
     5041 gcttttagta ctttaaagaa gttctcaata tcatctactt ctatctctcc taaagcacag
     5101 attctaaaag tatcctcagt tgatatctta cctggataaa tcgtaaatcc acgctcataa
     5161 caataatcat gtattttctc aaaatcccag ttgggatctt ctgggtattg aactgagaca
     5221 accagtcctg actgccattc acgctttatt acacttttaa gaccaatttc atttatacct
     5281 gaatgaatag cctcaaaaac tcttttgtga cgggcaaact tagcttcttc gcccacttca
     5341 aaatattcat ttaatgcctg acgagtggcg taaatagttt gtaccggtgg agtaaaatgc
     5401 atttcacctg ttctctcaaa attctcatac tgcaaataaa gattacaata gtaagaacgc
     5461 ttgggatatt tttttgaaac cttaatctgt tcctcattgc ctataataaa agaaagacct
     5521 gtcatcgctt gaagtccttt ttgagcagat gccatacaaa aatctacatt atctttctct
     5581 atatcaaaag gaatcatgcc caaagaagaa gtagtatcga cgacaaattt agcctgatat
     5641 ttatgagcta tatcgcccat ctcgcgaata gggttcagaa ttcctgtacc cgtctcgtga
     5701 tgagtagtat aaaccatagc tatatcagga ttttcttgta acacattttc cactaccgat
     5761 aaatcaggac gttcataaac agaaaattcc aaattaatat gaggcaaacc ataatattga
     5821 cacacttcta cagcgcgggt actatatgcc ccattattca ctataagcac ccttttgttt
     5881 tcaggaagaa gagaatttag acatatatca atattgatgg ttcctgagcc acaaaataat
     5941 acagctgtat gtttttccaa attcccatga gcaactctga ccaaatcgtc ccgaagttgt
     6001 ttcatcatac ctgcgaattc tttctcgcga ggacaaatat ccggaacaac ttgtgccatt
     6061 tttacactgt cagtagtagt ggcaggccca ggatttaata atatttttct ttctattttc
     6121 atcgaatata cttattttaa aaaatccata aaatgctcct tattctctat aggagtagtc
     6181 gtgggacgtc ccaaattctc ccgagaatct atcttaacct ttatttccaa caaaacagga
     6241 ccacataact ttggaagctg cttcattgct tcttcaattt caacttttgt acaaacagta
     6301 taagtatgct tatatccgct cccccggaca atagccggaa tatctaaact aaatcctaaa
     6361 gtaggctgtc ctcctacaga ctcgtgagca ccattgttaa acaaaatatg ataatagttt
     6421 ttaggagata aatcgccaat gttactaatt gcccctaaat gcataataaa tgctccatca
     6481 ccatccaagc aataaacagg tctatcttgc tttgctatag caatacccaa agagattgat
     6541 gaactatgtc ccatagagcc taccgtgaga aaatcatgtt catggccgtg ccctttcatt
     6601 tctcgatatt caaataactc acgagaaagc ttgccagtag tagaaacgac cactgaattt
     6661 tcaggcagat aatccacaac tatttgcaaa gcatcctcac gagacaaagg ataattacat
     6721 ccgaattctt tttgaagttt atatttgcca aaaacatctt tccgaataat tattgcatga
     6781 ggaatattct tagtttttgc tgattgtatg atatcatgga gctgaataaa tgcatcattc
     6841 tcatttgaat caagaattat ataaggaatc cgcattgctt tcaacaaatc taaagttacc
     6901 tcaccctgtt ttttatgctg aggttcatct tttgttcccg gttcaccacg ccagccaatc
     6961 atcaaaagca ttggaaaact gtatacttgt tcatctgcaa gagacagcag aggattaaca
     7021 gtattaccca agccggaatt ttgcatataa accacaggaa ccttacctga tgccatataa
     7081 taacctgaag caattcctac agccgcacct tcattagcag ctatgatatg tttctcacgt
     7141 gaagtatggt ctgtgatata ggcacaaata ttctttagta atgagtctgg aactcctgta
     7201 aaaaaatcaa cgtcatgact cagaaacgtt tcataaactt tttctacgct taacataatg
     7261 atattcctct ttttatttag tacctggaat cagttccaat atttctttta tgggcataca
     7321 cagttcgcgc acctctaaag cacgttcatt ctctaatatt gtctttgcga cattcatcat
     7381 agcaggataa gcggcacgaa gcatatgatt agcataaata attatattca caccccaatc
     7441 acacaattca gactcataaa tatgatcata tgtagtaggc acaaccacga taggtacatg
     7501 agcatactgt tttcgaaacg ccaaacaaaa ttcttttata tcttcacccg acttattttt
     7561 gctatgtatc ataataccgt ccgctcccgc ttggacatat gcaaaagctc tctctaaagc
     7621 atcacttacc ggctttcccg ctataaggct ctcaatacga gcgataatca taaaatcatc
     7681 agtaatctga gatgcctttc ctgctttgat cttattacag aaaccttcga ttgtatcttg
     7741 agtttgaata acatccgtac caaacaatga attctttttt aatccaactt tatcttcaat
     7801 tattatagct gagattccat gacgttctaa agtgcgtact gtaaatacga aatgttcaat
     7861 tttaccacct gtatctccat caaaaataat aggtttagta gtacactcca gaatattatt
     7921 caaatcttgc aatcgggtag ttaaatcaac cgcctcaata tcaggtttac ctttactggt
     7981 tgaatccgta aggctactag accacattcc gtcaaatact tccctcttat ccccttttaa
     8041 tatttcctga ttttcaatta tcaagccaca tagtccatca tgagcttcca aaatacgaac
     8101 tacgggtttg gcatttatca aacgacgaag tgattttaaa cgtacatcgg gggttgtacc
     8161 tatagcctta atatctttat ccaaagaaga tgaattaatt cccaaagtat atggaatttc
     8221 gataaccttt cctccctgtt cattcatcac ttcaaatacg cgcacacgtt cttcacgtaa
     8281 aggcccggtt ttccagtcgt caccatgaat tatatagtca ggtttaatgc gtttgagatt
     8341 ctcaacatag ctccattctt cttgaggaac aactttacat acgcctttaa tattctgaac
     8401 tacctctttt cgttgttcat aggtcagata aggaaggcgt ttatgctccg caatagcttt
     8461 atctgtaaga agaccaatta taacatcacc gtatttagta gcctcattaa taatgcggat
     8521 aagtcctgga tgcataatat ccgcagtcat cccaatataa actgtcttac tcataatttg
     8581 atatattatt ttaattaaca atacggaaca atatatttct ctgcatattc caaatctgat
     8641 atgtcatcga tttcatacca tttcagccct tctactttat gcacataaac aggagattga
     8701 gaacaagata ttcgtagtaa ttcatactca tatcccaaat tgggttgttc atcaacaata
     8761 ctcgcataat cagcacacat tattttgtaa aaggaaccgg atagtttatg gatgccgacc
     8821 aattcgcctt tagcgtttag tttattctta ttgacagaac atgaagaaag gcgaaaatta
     8881 tcatcatgtt ccacataata ctgatcttga aactttgtca ctggagttat tagcattgca
     8941 tctgccgcag gacactccaa taagctcatt atggcttgtt tctcaaaaat caaatctgac
     9001 tctaacaata aaaaatcatc attgcccaga atctcccgcg tattatataa agtatacata
     9061 ctatttgttt cagcataacg aggactaaaa caggtttcaa gcataggata ttctgtcttc
     9121 aattcttcat aaacttcttg tttatatcct gtaccgatta caattcgctc aatgccacat
     9181 gataacaaag tatcaataga acgaactatc attggaatac ctcccacttt gacgaaccct
     9241 ttaggtatca attctgtata ttggccaaaa cgggttccca tgcccgcagc cattatcata
     9301 gctgtacgta tcattcgttt aataatatag taagtgaatt taattgatgt aagaatgttg
     9361 taaacgacgt tttagcatca tttatcctgt tctatctcct tatttttcag ttcttttctc
     9421 aagctagcca gcagactttt gccaaaaagc acccacacga gagtaccaga tacggacagg
     9481 aacacaaata ataaaatata aattttgagt cccatacctg aaggtttcaa aggtacaacg
     9541 gcaggctcaa ctactgcaaa gaccggcttt tcctcctgta ctttggctct ggatacctgc
     9601 aactgattag caacctgact atatatctga taagccagac tcatgtcgtt ctgtaaacgc
     9661 tcctgctcag tacgtacact ttgaagaacc acattatcat gggcgtctac ataatccgca
     9721 tattttcttt gagcagcata atattcctgc tgacgctctt taaacaaccg ttccaaatac
     9781 gcacagtctt cttttacttt tgaagttcga tacccaataa tatattcctg taatttatga
     9841 acgacagaat ctgctataac cgcagtgatc tgcggatttt gtaaggtgac agtaatgctc
     9901 gttatggcgg ttttcttatc aatggatgca ctaatcttct ttttaagaaa attaatcttc
     9961 tcatttactt ctttcgtcaa ttcgatagtt ccttgccgcc ctccaccggc aggaaccgta
    10021 tcttctccga ataatgattt aactccccct attaccatgc ccggaaaacc tataagataa
    10081 tcccaccagg gagatgactc ttcatcgaga taagactcca aagtcatttt atcatccttt
    10141 ttagaaacgg agacttccat ttctaaaagt tccaataaaa aaggagttga agaaacaata
    10201 tctgctgaaa gagaagcgtt caaggcatct gtgctttccc ctattagagc cccatctccc
    10261 aaaaacgagg cagcaagtcc ggctaaacca ttacttccct tcgcattacc catttcagga
    10321 gaaagggtaa cctttactgt atattgcttg ggaatgctca atgccaccac tatagcaatt
    10381 attactccca ctccagcagc tttgcatagt actccacgaa cagtaataat cttataaaaa
    10441 atagccatca agtctatttc catttcatca tctttccttt tatccacttc agaaaacggt
    10501 tcttgataag attgcttttc aatcataata ggtcatttat ttctttatca aattagcaat
    10561 agaagcaatc atcataccca aagaactgaa ggaagtag
//
