LOCUS       c00025_gnlPro..        14466 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DAOEDJMK_25.
ACCESSION   c00025_gnlPro..
VERSION     c00025_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 16:48:58
            Original ID  :: gnl|Prokka|DAOEDJMK_25
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14466
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14466
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:4466]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..4466
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14466
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14466
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             3..314
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_1"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.9e-16, bitscore:
                     50.5, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="YNIETVEDQKVRTAFLKVGETKIELLEPTCPESTIAKFIENKGAG
                     VHHVAFAVEDGVANALAEAEGKEIRLIDKAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             343..1896
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_2"
                     /sec_met_domain="CT_Btheta (E-value: 2.6e-290, bitscore:
                     952.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             1928..2848
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_3"
                     /sec_met_domain="OAD_gamma (E-value: 8.9e-16, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQNNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWIGLFDSGRKLLDQIVVPAGVLGPNQSYARVSDGAAEW
                     EVKGGSGDKYVTPSTNNKTLDSNAKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             2873..3304
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 5.2e-22, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPA
                     AKPVTVRPMPNAPTAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             3306..4466
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_5"
                     /sec_met_domain="OAD_beta (E-value: 3.5e-153, bitscore:
                     499.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLGFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             4761..6101
                     /locus_tag="ctg25_6"
                     /transl_table=11
                     /translation="MKRIIILFFLCCTIPLIAQHTDPIQEAMANYDYETALSLIAQKKT
                     TPPLLLQKGKALRGLGLTTEALATYQEIICNDTTNTRAFIEAAECCRALAKYNQALKYY
                     EHALDLNPENKYVRIQYISLLLSQQKFSEALGESSLMTEKDSSAIVLHLQAQSFEGMGE
                     LLPAAGCYYNIQAKYPDDYLAASKLGALNISGSYFDEAIEATEKYRQIDSTNISVNRQN
                     ALAYCLKQDYPTAIRRYEYLVSQGDSSFHTCYYLGISYYAAEKYYEAHDFLEVARKYDP
                     NNINLLYYLGRACSKTSWKKEGVDYLEKTIDLSIPKDSSMTRLYIGMTDCYKMAQMYKE
                     QIASIKERYQRYDKQNHKLLYDMAYIYFYDLKDKKNAERYLEAFLKTRPKDTKEEAEMN
                     ERGELVLGKSNYYNAAAKWLKDIQSKQKIEDFFQNSSPQLPLPKKDK"
     CDS             complement(6186..7190)
                     /locus_tag="ctg25_7"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPEEEVETINKYGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKILNVLGSDNKLAQ"
     CDS             7624..7878
                     /locus_tag="ctg25_8"
                     /transl_table=11
                     /translation="MKKGLHPESYRPVVFKDMSNGDMFLSRSTVATKETIEFEGETYPL
                     LKIEISNTSHPFYTGKSTLVDTAGRVDKFMSRYGDRKKK"
     CDS             complement(7958..9172)
                     /locus_tag="ctg25_9"
                     /transl_table=11
                     /translation="MINREQYMEQIVPFIDKPFVKVITGIRRSGKSVVLRLIRDELLRR
                     GVREERIIYLNFESFQWIDLKEAKALYAYIRGQAGDAGKYYILLDEIQEVDGWEKVVNS
                     LLVDLDTDIYVTGSNSRMLSSELATYLTGRYVAFHVMTLSFREYLTFHDLQANDPTLNR
                     KEEFQKYLRMGGFPAIHTADYGYEAIYKIVYDIYSSVILRDTVQRHNIRNVELLERVVK
                     FVFDNIGNKLNAKNIADYFKSQQRKVDMNTIYNYLNALESAFIIQRIPRYDIKGKEILQ
                     TNEKYFVSDLSLIYSVMGYRDRLIAGMLENLVCLELKRRGYEVYVGKQDDKEVDFVAIR
                     REEKIYVQVTYQLASQATVEREFAPLLAINDHYPKYVVSMDSLWQDNVEGVRHRHIADF
                     LLDDA"
     CDS             9366..9773
                     /locus_tag="ctg25_10"
                     /transl_table=11
                     /translation="MEITDLKQMTKEEVFNFIRQRLSFSKELQEQFRHVNKDDLAKEHR
                     RFEMSGNESKTGQCTIFNTAILNEFADLGIYDYTSYLFLDFHNGTPTVYLKYFSENENL
                     EYTFTGYTTTEIIFAILELTIFSGKPKRNRS"
     CDS             10505..10936
                     /locus_tag="ctg25_11"
                     /transl_table=11
                     /translation="MPKWISVEKAVIKYHIEKEAILLWVEMGQFPMLYIDNVPNVDEEC
                     ILELFRRSKAGITAEYIDTLEQLCIDKTMVCEKYAHIIQLKEKEIQLQKEINTSINEIQ
                     AAMKRQNERIRDLKKAIGENNNVIRSDSWIKRLRKRFQW"
     CDS             11194..11547
                     /locus_tag="ctg25_12"
                     /transl_table=11
                     /translation="MKNDSCLTVSRRAAIIRQDAEENYGTLLTLGESMRRAYQVEELID
                     RMRWDNADFCLQRTDGTCLSITGTLTEYEHYFGRPYYENPSNRFLPYYDVHCRKWLTCR
                     VAGIVFGSSVKKN"
     CDS             11886..13190
                     /locus_tag="ctg25_13"
                     /transl_table=11
                     /translation="MTTSNSANTKQSNNASQKRKPIHNGYFNHPTSSSSNIPMSILIRE
                     QGLEIYGLYWVMLEEAHAQLKCCVNIQTMGIIANIFHAQPEHLELLYHHYFRRPGKGYN
                     SHILYADFCEESAIRSYFPHPLLAYTDNELLRMIMQDGLKAYGLYWLVMEKLYQQPQHF
                     LAPQTASFIQNLYDVSDELMESVLYNYGLFYLDEKMNLHSKAIDDYREALDNMEDEKKR
                     NTKPHVNNSLKANGNAEDFNTREMKNTSNIQKNPSPIINKEINKKNSSSEESGKEKEEE
                     NGLKVTDLNAVTPDMRPNAWEENLQEAMNDTSWYEVVAIQSGIPRLMMEEKEWFFNYLR
                     EQIILRGNESSMNSLHEIKNYFANLTRQGSHVSSTTQVALKKFLKNRQEQQQCSPYETI
                     TNGIRTYDGHPIPAYAKPRPSAAHIWNPVTNEWTR"
ORIGIN
        1 gttacaacat tgaaacagtg gaagatcaga aagtaagaac tgctttttta aaagtgggcg
       61 aaacaaaaat tgaactgttg gagcctactt gcccggagag tactattgcc aaattcattg
      121 aaaacaaagg tgcaggcgtt caccacgtcg catttgctgt agaagatggc gtagccaatg
      181 cgctggcaga ggcagaaggc aaagaaatcc gccttatcga caaagctccc cgcaaaggtg
      241 ctgaaggttt gaatatcgct ttccttcacc cgaaatcaac tttgggtgtg ttaacagaac
      301 tctgcgaaca ttaatcataa actctaaaac caacaagaac tcatgagtaa tcaacttgaa
      361 aaaattaaag agcttattga acgccgtgcc gtagcacgta tcggaggcgg tgaaaaagca
      421 attgcgaagc aacacgaaaa agggaaatac acagcacgcg agcgtctggc tatgctgctt
      481 gacgagggta gcttcgaaga aatggacatg ttcgttgagc acagatgcac gaacttcggc
      541 atggagaaaa aacattaccc gggagacggt gtagtaaccg gctgcggtac gatcgaagga
      601 cgtctggtat atgtgttcgc acaagacttc actgtttctg ccggttcact gtcagaaacg
      661 atgtcattga aaatttgtaa aatcatggat caagccatga agatgggcgc tccctgtatc
      721 ggtatcaacg actcgggtgg tgcacgtatt caggaaggta tcaacgcttt ggcaggttat
      781 gcagaaatct tccaacgcaa tatccttgct tccggtgtta tcccacagat ttcaggtatc
      841 ttcggtcctt gtgccggcgg tgctgtttat tctccggctt tgaccgactt cacgctaatg
      901 atggaaggta cttcttatat gttccttacc ggaccaaaag ttgtgaagac cgtaacaggt
      961 gaagacgtta gccaggaaaa cctcggtggc gcaagcgttc actccactaa atcaggtgtg
     1021 actcatttca ccgctaaaac agaagaagaa ggtttcgaac tgattcgtaa actgttgagt
     1081 tatattcctc aaaacaacct tgaagaagct ccttatgtag attgtacaga cccaatcgac
     1141 cgtttggaag attctttgaa tgatattatc cccgacagcc ctactaaacc gtatgacatg
     1201 tacgaagtga tcggcgctat tgtggacaac ggtgaattcc ttgaaatcca gaaagattat
     1261 gcaaagaata tcatcatcgg tttcgcccgt ttcaacggac aatcggtagg tatcgttgct
     1321 aatcagccta agtatctggc tggtgtgctc gacagcaacg catctcgtaa gggtgcacgt
     1381 ttcgttcgtt tctgcgatgc attcaatatt cctatcgtat cgttagtaga cgtaccggga
     1441 ttccttccgg gaacaggtca ggaatacaac ggcgttatcc ttcatggtgc taagctattg
     1501 tatgcttacg gtgaagctac tgtgcctaag gttactatca cattgcgtaa atcctacggt
     1561 ggttctcaca tcgtaatgag ctgtaagcaa cttcgcggtg acatgaacta cgcatggccg
     1621 actgctgaaa tcgcagtaat gggtggagca ggagcagtag aagtattgta cgcacgcgaa
     1681 gccaaagatc aggaaaatcc cgctcaattc cttgctgaaa aagaagcaga atacacgaaa
     1741 ctgtttgcca atccttacaa tgcagccaaa tacggctaca tcgacgatgt gattgaacca
     1801 cgcaacacac gtttccgcgt aatccgtgct ttgcagcagt tgcagactaa gaaattgagt
     1861 aatccggcta agaagcatgg taatattccg ttgtaatcct acttttcaca ttaaaacaag
     1921 aacgattatg aacaaaacca aaatcggaat attcctttct ttgctgttgc tgattgggct
     1981 gacttcttgt ggagagcaaa agtcgaacaa caagctggta ctgaacgaaa tcctgataga
     2041 caatcagaat aattttcaag atgactacgg attgcacagc gcatggattg aaatattcaa
     2101 taaatcattc ggtagcgccg acctggcagc ttgcttgttg aaagtaagca gccaaccggg
     2161 cgatacagtt acttacttta tcccgaaagg tgatatactt acattagtga agccacgtca
     2221 acatgcacta ttctgggcag atggcgaacc taaccgcggt actttccaca ccagcttcaa
     2281 gctgaatccg gaaacggcca actggatcgg tctgtttgac tccggtagaa agctgctcga
     2341 ccagattgta gtgcccgcag gtgttcttgg ccccaaccag tcatacgctc gtgtcagcga
     2401 cggagcagcg gagtgggagg taaaaggtgg aagtggtgac aaatacgtga ccccgagtac
     2461 gaacaacaaa actcttgaca gcaatgccaa gatggaaaaa ttcgaagagc atgatgctga
     2521 cggtgtcggc atgtccatct ctgccatgag tgtagtattc tgcggattga ttcttctctt
     2581 tattgccttc aagattgtag gaaaagtagc tgtaaatttg agcaagcgca atgctatgaa
     2641 atctaaaggc attgacaagc atgaagctaa ggaactgtca caggctccgg gcgaagttta
     2701 cgctgcgatt tctatggcat tgcacgaaat gcaggatgaa gtgcacgacg tagaagaaac
     2761 ggtactgacc atcactcgcg taaaacgcag ttactcacca tggagttcga agatttacac
     2821 tttgcgtgaa actcctccca gaaagtaagt caccttttaa aaagttaaaa cgatgaaaga
     2881 atataaatat aaaatcaacg gtaactcata taaagtaacc atcggagata ttgaagataa
     2941 tatcgctcat gtagaagtga acggtacaca ctataaagtg gaaatggaga aacagccgaa
     3001 gcctgctgcc aaacctgtaa cagtacgtcc tatgcctaat gctcctactg ctcctactca
     3061 ggtagtgaaa ccgactgctc cgtctaccgg aaaatcagga gtgaaatctc cgctgccggg
     3121 tgttatcctc gacatcaaag tgaatgtagg cgatactgta aagaaaggac agaccattat
     3181 catattggaa gccatgaaga tggaaaacaa tatcaatgcg gataaggacg gtaagattac
     3241 tgccatcaac gtcaacaagg gagactctgt tcttgaaggt aatgacctcg taattattga
     3301 ataatatggg agattttata aactttttag gaaataacct cgccgacttc tggacataca
     3361 cgggctttgc aaatgctact gtagggcatg tcgttatgat tcttgtgggt ttggggttca
     3421 tctatttggc ggtagccaaa gagttcgaac cgatgctgct gattcctatc ggcttcggta
     3481 tgctgatcgg taatatacct tttaatatgg atgccggact gaaagtcggt atttatgaag
     3541 aaggttccgt attgaatata ttgtatcagg gagtaacttc cggctggtat ccgccgctca
     3601 tctttttggg catcggcgcc atgacggact tctcggcact tatctctaat ccgaaattga
     3661 tgttgatcgg tgctgctgca caattcggta tcttcggtgc ttacatgatc gcattggaaa
     3721 tgggcttcga cccgatgcaa gccggcgcta tcggtatcat tggtggagca gacggcccga
     3781 cggccatttt cctttcttcc aagctagcac ctaacctgat gggagccatt gcggtgtccg
     3841 cctactccta tatggcgttg gttccggtga tacagccgcc tatcatgcgt ctgctcacca
     3901 ccaagaacga acgtgtcatc cgcatgaaac cgccgcgtgc cgtttctcac acggagaagg
     3961 tgattttccc gatcatcggt ttgttgctga cctgtttcct ggttccttcc ggtctgcctt
     4021 tgttgggtat gctgttcttc ggtaacctgt tgaaagaaag tggtgtaacc cgtcgtcttg
     4081 ccaatacagc tagcggtccg ttgattgata ctatcactat cctgttgggt ctgacagtag
     4141 gtgcttctac gcaagcttcc gaattcctga cgctcgattc tatcaagatt ttcgccctcg
     4201 gtgcattgtc attcatcatt gcaactgcat ccggtgtaat cttcgttaag atattcaata
     4261 tcttcttgaa gaagggcaac aagatcaatc cattgatcgg taatgcaggg gtttctgctg
     4321 tccccgactc tgcacgtatc tcacaagtga ttggtttgga atacgattcg accaactatt
     4381 tgttgatgca cgctatgggt ccgaacgttg ccggagtgat cggttcagct gttgctgccg
     4441 gtatcctgct cggattcttg atgtaagata taaggaggct gtttgaacag ttcttaaaat
     4501 aaaaaataag actatcctaa aagccttgaa tttataaaaa tcacctttgc tacattatag
     4561 tagtaaaggt gatttttcat tataaggact tgctgtaaaa aagaccgtag ctaccatgcc
     4621 ccatgtattg tattgcgcac tgttgtgtta ccttctctta tcattccgtt aatctatcca
     4681 aaataatcta cgaataattc gtaaatataa tatttttagt aacttgcagc agataagtca
     4741 aacaactaaa ataaaatatt atgaaacgga ttatcattct gttctttctt tgttgtacca
     4801 ttcctctaat agcgcaacac acagacccta ttcaagaagc tatggcaaac tacgattatg
     4861 agacggccct ttctcttata gctcaaaaaa agactacccc tcccctgcta ttacagaaag
     4921 gcaaagcgtt gcgtggacta ggactcacta cagaggcact tgctacctat caagaaatta
     4981 tctgtaatga tactacaaat actcgtgctt tcattgaagc ggccgaatgt tgccgagcac
     5041 tagctaaata caatcaagca ctaaaatatt atgaacatgc acttgatctg aatccggaaa
     5101 acaaatatgt acgtattcaa tatatcagct tgcttctctc ccaacagaag tttagcgagg
     5161 cgcttggtga aagtagtctg atgacagaaa aagacagttc cgccattgtc ctgcatctac
     5221 aagctcaaag ctttgaagga atgggcgaac ttcttcccgc tgcaggttgc tattacaata
     5281 tccaggctaa atatcccgac gattatctgg cagccagcaa actaggtgct ctaaatatat
     5341 ccggttctta tttcgacgaa gccatcgaag ctacagaaaa ataccggcaa attgacagta
     5401 ccaacatttc cgtcaaccgg cagaacgctt tagcgtactg cttgaaacaa gactacccca
     5461 ctgctatccg gcgttatgaa tatcttgtca gccaaggaga cagttctttt catacttgtt
     5521 attatttagg catcagttac tatgcagcag agaagtacta tgaagctcat gattttttgg
     5581 aagtcgcccg taaatatgat cccaacaata tcaatctcct ttattacctc ggtcgcgcct
     5641 gttccaaaac ttcctggaaa aaagagggcg tagactatct ggaaaaaacc attgatctat
     5701 ccattcccaa agatagcagt atgactcgac tttacatcgg gatgaccgac tgttacaaga
     5761 tggcacaaat gtacaaagaa cagattgcat ccatcaaaga acgctaccag cggtatgaca
     5821 aacaaaacca caaactattg tatgacatgg cctatatata cttctatgac ttgaaagata
     5881 agaaaaatgc ggaacgctat ttggaagcat tcctaaaaac acgtcctaaa gacactaaag
     5941 aagaagcgga gatgaacgag agaggcgaac ttgttttagg aaaatccaat tattacaatg
     6001 ccgccgccaa gtggctgaaa gatattcaaa gtaaacaaaa gatagaagac ttctttcaaa
     6061 attcctctcc acaacttcct ctcccaaaga aagataaata gataagaact ataaagcaac
     6121 taaaaggctg ctaccggttt atcggtagca gcctttcttt tatttatgga ataatccgga
     6181 gattattact gtgccaattt gttgtcagaa ccgagcacat tcagaatttt gtgcttgtac
     6241 agtttttcca tattgtcacg agccgggcca agatacttac gtgggtcgaa ttcagccggt
     6301 ttttcagcga ataccttacg tatagcagca gtcatagcca gacgagagtc agagtcgatg
     6361 ttgattttgc aaacagcaga cttagcagct ttacgcaatt cttcttccgg aataccgata
     6421 gcagctttca gtgcaccacc atatttgttg atagtttcca cttcttcttc cggaactgaa
     6481 gatgatccgt gaagaacgat agggaatccc ggaagttttt ccattacagc gtccaatact
     6541 tcgaaagcca atggaggagg aaccatacgg ccagtcttcg ggtcgatgtg gcattgttcc
     6601 ggagtaaatt tgtaagcacc gtgagaagta ccgattgaga tagccaaaga gtcgcaacca
     6661 gtgcgagtag cgaagtcgat tacttcttca gggtcagtat atgtgtgatg gtcggaagaa
     6721 acttcatctt ctacaccagc caatacgcca agttcacctt ctacagttac gtcaaactgg
     6781 tgagcgtatt caacaacttt cttagtcaat gctacgtttt cttcgtaagg aagatgagaa
     6841 ccgtcaatca tcactgaaga gaaacctgaa tcgatacaag atttgcaagt ttcgaatgta
     6901 tctccgtggt caagatgaag aacgatttcc ggatgtgcgc agcctaattc tttagcatat
     6961 tctacagcac cctgtgccat gtaacgcaac aaagtagcgt tagcatactg acgagcacct
     7021 ttagaaacct gaagaatcac aggagattta gtttcaacag cagccttgat gatagcctgc
     7081 atttgttcca tattgttgaa gttgaatgct gggatagcat atccaccttt gatagcctta
     7141 gcaaacattt ctcttgtgtt taccaatcct aaatctttgt aatttaccat tttgtttaaa
     7201 gtttattgtt agtgaataaa aattctacgc aaaagtaagc attatccatc gaataacgaa
     7261 catcggaaag aaaaatatag tagaaaaagg tttaaatcag actgcaaaat ttagcaggaa
     7321 tacgagtgtg acattagatt gtaatgtcca ccttgcaaac tttgggattt atgatttctg
     7381 aattctgatt gatgccttcg gatttatatc tccttattta taccttattt atacctcatt
     7441 tttcattcat ttaatcacca aaatctgcat agccaatcag aaatcataaa ttagaaatca
     7501 gaaattttag aaaacctttt tctatttcac agaaaagcat tatctttgcg ctctgaaaat
     7561 gaccattaca ctatttctta ccaaaatagt aacagaatat aaattaaaaa aacagatact
     7621 gaaatgaaaa aaggccttca tccagaatca taccgtccgg tagtatttaa agatatgtca
     7681 aatggtgaca tgtttttgtc tagatcaact gtagcaacta aagaaaccat cgaattcgaa
     7741 ggtgaaactt atccgttgct gaagattgaa atctcaaaca cttctcaccc gttctataca
     7801 ggtaaatcta cattggtaga tactgcaggt cgtgttgaca agttcatgag ccgttacggt
     7861 gaccgtaaga agaaataatt cgatctttcg tgaaagatga aaaagaggag attctcgcag
     7921 agaatttcct ctttttcgtt ttctatattc cttaacgtca agcatcatcc aacaagaaat
     7981 cggctatatg acgatgcctg acaccctcca cattatcctg ccacaagctg tccatgctaa
     8041 ctacatattt aggataatgg tcgttaatgg cgagcaaagg agcaaactcc ctctcaacag
     8101 tggcctgtga agctaactga tacgttactt gcacataaat cttttcttcc cgacggatgg
     8161 ctacaaaatc cacttcttta tcatcctgtt tgcctacata cacttcatac ccccttcttt
     8221 tcaactccag acagaccaga ttctccaaca tacctgcaat caaccggtca cgatagccca
     8281 tcacggaata aatcaaagaa aggtcgctta caaaatactt ctcattcgtc tgcagaattt
     8341 cctttccttt aatatcatat cggggaatac gttgaatgat aaaagcactt tccaatgcat
     8401 tcagataatt atagatggta ttcatatcca ccttccgttg ctgacttttg aagtaatcgg
     8461 ctatattttt agcgttcagc ttattgccta tattatcgaa aacaaacttc actacccgtt
     8521 cgagcagttc cacattccgg atattgtgac gctgcaccgt gtcacgaaga atgacagaag
     8581 aatagatgtc gtagacaatt ttatagatag cctcatatcc ataatcggca gtatgtatgg
     8641 ccggaaatcc tcccatacgg agatatttct gaaattcctc cttccggttg agcgtcggat
     8701 cattggcctg caagtcatgg aaagtcagat attctctaaa agacaaggtc atgacatgga
     8761 aagcgacata ccgtcccgtt aaataagttg ccagttcgga cgataacata cgtgagttgg
     8821 agccggtcac ataaatatcc gtatccaaat ctaccagaag tgagttgacc actttttccc
     8881 aaccgtccac ttcctgaatt tcatccaaga gaatataata tttacccgca tctcctgcct
     8941 gcccccgaat ataagcatac aaagccttcg cctctttcag atctatccac tgaaaacttt
     9001 caaaattcag ataaatgata cgttcttcac gaactcctct cctcaacagt tcgtcacgaa
     9061 tcagacgcag cactaccgac tttccactgc gacgaatacc cgttatcact tttacaaacg
     9121 gcttatctat aaaaggaacg atttgttcca tatactgttc acgattaatc atattcaaaa
     9181 gtttttaggg ttataagcac aaagatatac tattttcgga aagtttttag ggttataacc
     9241 ctaaataaat ccataaattc agattctttt agggttataa gccgaaaaat aaataaaaga
     9301 aatatgacta aatccgattt attaccaaat aaagaaagta cctttacccc aataattaat
     9361 aaaaaatgga aataaccgat ttaaaacaaa tgacaaagga agaagttttt aatttcatca
     9421 gacaacgcct ttctttcagt aaagaactgc aagaacaatt caggcatgtg aataaagacg
     9481 atctcgcaaa agaacatcgc agattcgaaa tgtccggaaa tgaatcaaag acaggccaat
     9541 gcacgatttt caacacagcg attctgaacg agtttgccga tcttggcatc tatgattata
     9601 cttcttacct ttttctcgac ttccacaatg gcactccaac cgtttatctc aaatacttct
     9661 ccgaaaatga aaatttggaa tatacattta ccggatatac cacaacggaa atcatctttg
     9721 caattcttga actgactatc ttctccggaa agcccaaaag aaatcgcagc taaaaaaaga
     9781 attgcacgga aagacaatac gaggtcaaaa gacttttatg gctttcattt aagcacggat
     9841 tacacggatt tcacggttcc attagactaa aaccgtgaaa ctcgtgtaat ccgtgcctaa
     9901 ataatatcaa tctaatagat ggttttactt ttggctccct cctttttatc atcacattat
     9961 atttgccacc cgtatagcat atttaccatc tttataccat actctctatt ctcataccat
    10021 atttcctgca tttatttcct cttttccatc ctattccgaa aaaaacatat atctttgtca
    10081 tacgctttct gcccatcagc gtgatgaaac aggcaaaagc ggtttttatt ccttaatgga
    10141 gtaaataacg tattgtttcc caaatcgaaa cttagcaaat ttcatgcacc gggaaatgat
    10201 acaacagata ctccacgtag atgatcgtat atcaacatat cgattagaga tttgttatat
    10261 ataaacgttt ggcgtgggtg tctgttgttt atcattatct ggtgcacggt atgctaagac
    10321 ctcgatttag ataatggtac aacagcactc acgcttttat tgtatccggt cggtttcaac
    10381 aatccttata ccccaaccaa ttccccaccc gaccgaaatc ataaaaatcg tgggtgttcg
    10441 ttgcacctct ccggacaata cgttatttac tccttttttt ataacacatt aaaacaaaag
    10501 caatatgcca aaatggatta gtgtagaaaa agcagtgatt aagtatcaca tcgaaaaaga
    10561 agcgatcctg ctttgggtgg aaatgggaca atttcctatg ttatacatag acaatgttcc
    10621 gaatgttgac gaagaatgta ttctggaact ctttcgccga agtaaagccg gcattacagc
    10681 agaatatatt gatacgctgg aacaactgtg catagacaaa acaatggtct gcgagaaata
    10741 cgcccacatt attcaattga aagaaaagga aattcagctg cagaaggaaa taaatacgtc
    10801 gataaacgaa atacaggcag caatgaagag acaaaacgaa cgaatccggg atttgaaaaa
    10861 agcgattgga gagaataaca acgttatacg tagtgacagt tggataaaaa ggctgcgcaa
    10921 aaggtttcaa tggtgaaaga gggccgtcct ttgccctttg cagcctattt ccattccctc
    10981 cacagctttc tttaaactcc tccataagct ctttaaagcc tatattcaga caatgaaaaa
    11041 atacaaaata ttttattcca tttatttaac taatcatcta ttatataagt aattttatcc
    11101 tttgtaaagt caagtaaatt cactacattt acaccactaa caagaactga aatgtgagca
    11161 tttcagcaca aagaaatctg tatgaaaaaa acgatgaaga atgacagttg cctgacggtt
    11221 tcccgtcggg cagctattat ccgccaagat gcggaagaga attacggcac actgttgaca
    11281 ctgggagaat ctatgcgccg tgcataccaa gtagaagaac tgatagaccg gatgagatgg
    11341 gacaacgccg atttctgcct gcaacgaaca gacggaacct gcctttccat tacagggaca
    11401 ctgacagaat atgaacacta tttcggccgc ccctactacg aaaacccctc caacaggttt
    11461 ctcccatact atgacgtgca ttgtagaaaa tggcttacgt gtcgagtggc agggattgta
    11521 ttcggctctt ctgtgaaaaa aaattaattt catggattaa ataaggaaag ttgtaggaca
    11581 tatacgaaat aaagtagtta ctttgcaacc gcaagtaaga gaaaaaatca tgtcaatgct
    11641 gcttccttgt tttttgacag aagcagttat ctgtttttcc agcattgctt tttcagaact
    11701 tcggaattaa atctcccctg ctccgaaaat tccctatatt acagattaca tacacgaaga
    11761 gaatactccg attccatcat gaagaatgag tacgatattt gctgctttcc aaagaagtgg
    11821 ccggattctt cgtatctgta ttttcagaaa aatagaattt aaaacagaaa ctaatatatt
    11881 ttattatgac aacatctaat tcagcaaata ccaaacaatc gaacaacgca tcacaaaaga
    11941 gaaaaccgat tcataacggt tacttcaatc atcccacttc ttcttccagc aatataccca
    12001 tgagtatttt gatacgggaa caaggactgg aaatatacgg actatactgg gtgatgctcg
    12061 aagaagctca tgcacagctt aaatgctgcg tcaatatcca gacaatggga atcatcgcca
    12121 atatattcca tgcccaaccc gaacatcttg agctcctcta ccaccattat ttccggcgtc
    12181 ccggtaaagg atacaactcg catatactct atgccgactt ttgcgaagaa tctgccatca
    12241 gaagttattt cccgcacccc ctactggcat acaccgacaa cgaactgctg cggatgatta
    12301 tgcaagacgg actgaaagcc tacggactat attggcttgt gatggaaaag ctctatcaac
    12361 agccacaaca ttttctggca ccgcaaactg cttccttcat ccagaacctt tatgatgtga
    12421 gcgacgaact gatggaaagt gtattataca attacggact cttttatctg gatgagaaaa
    12481 tgaacctcca ttctaaagca atagacgatt atagggaagc acttgacaac atggaagatg
    12541 aaaaaaagcg caacacgaaa ccgcacgtca ataactctct gaaagccaac ggaaatgcag
    12601 aggattttaa cactcgggaa atgaaaaata cgtcaaatat acagaaaaat ccatccccca
    12661 ttataaataa agaaataaac aaaaaaaatt cttcttctga agaaagcgga aaagaaaaag
    12721 aagaagaaaa tggtttgaag gtgacggact tgaacgctgt gacacccgat atgcgcccca
    12781 acgcatggga agaaaatcta caggaggcaa tgaacgacac atcctggtat gaagtcgtag
    12841 ccattcagtc gggcatcccc cggctgatga tggaagaaaa agaatggttc ttcaactatt
    12901 tacgggagca aatcatctta cgggggaatg aaagctcgat gaacagcctg cacgaaataa
    12961 aaaactattt cgccaatctc acccggcagg gaagccatgt gtcatccaca acgcaggtgg
    13021 cactgaagaa gtttctcaaa aaccggcaag agcaacagca atgttcgccc tacgaaacca
    13081 tcaccaacgg aatacgtacc tacgacgggc atcccatccc cgcttatgcc aagccgcgac
    13141 cttcggcggc acatatctgg aatccggtga cgaacgaatg gacacgatag catattatct
    13201 ctcaatcatt tactaaatat ggatagattc aaagaactgg gtattgatac ccacggtcgc
    13261 acaagcggca aaatgaaaac aaaatgtccc tggtgtcatg cccaacggac ggataagcgt
    13321 gataaatcac taagtgtcaa cctcgatacc aaactgtatt tgtgccacta ctgcggcgca
    13381 cacggttcgg cagccatata tgccggaaaa ggcagaaagc tgggtgatcc gttggtcaaa
    13441 tttccaacgg caacaggtag caactccagt tgtccgccca ctgaaaagcc gcacggcgac
    13501 ccagagcaag gggcactcac acagaagcaa attgaatggt gtcgtgacgt ccgccacatt
    13561 ccgccggaag tattggtgga agctggcgtg gctttcgcct ccatctcgat gcctatatcc
    13621 ggaaaggaga aaggctggga aaagagggac tgtctctgct tcaacttttt cgaaaacggg
    13681 gaattggtga acacgaagtt ccgcgactca caaaagcact tcaaattact gcaaggagcg
    13741 cgcaccatcc cttacaacat cgacgccatc cgcgacacgc cggagtgcat cctcgtggaa
    13801 ggggaatttg atgccctctc ctacatggct gtcggccgga cggatgtcat ttccgtgccg
    13861 aacggtgcca acagtcaact ggactggctg gacgaattgt cggaatctca tttcgagcag
    13921 aaacaagtga tttatctgtc ggtggacacc gaccgcaagg gacgggaact gtgccgggaa
    13981 ctctcccgac ggctgggggt agaccgctgc cgtatcgtca cctacggcga agcatacaag
    14041 gacgccaacg aactgctcgt ggcggaaggc ccggacgcac tactgaaggc actggaggac
    14101 gcacccatcc cccgcctgga aggtacgttt acggcagaag acttacggga gcggttgcac
    14161 caactgtttg aagaggggta tacttcgggc gtggaattgg gaataccgaa tctggacgaa
    14221 atcatgaggc tggaaacggg gcgggtgctc accgtcaccg gtattcccgg acatggcaaa
    14281 tcggactttg tagatgagat agtgctccgg ctctgcaccc gccaagattg gcgagcggga
    14341 tatttcagtc cggagaacac gccaatcgag tatcatcatg ccaaactggc ggagaaactg
    14401 ctgggacacc gtttccgcaa agatttctct acggaggagg aattcgcccg cgtagtggat
    14461 tatctt
//
