LOCUS       gnlProkkaICKNNHJK_104  12971 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ICKNNHJK_104.
ACCESSION   gnlProkkaICKNNHJK_104
VERSION     gnlProkkaICKNNHJK_104
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 16:33:40
            Original ID  :: gnl|Prokka|ICKNNHJK_104
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12971
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12971
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3657:7971]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3658..7971
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12971
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12971
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..2435
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 30.5;
                     E-value: 2.4e-09)"
                     /gene_kind="transport"
                     /locus_tag="ctg104_1"
                     /sec_met_domain="Poly_export (E-value: 2.4e-18, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLFYLSMKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDG
                     IRQGKEQKQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKN
                     TSDMLEDHPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWG
                     ASQNTIRQQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDI
                     RLTLGNIRTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKN
                     IATIDVYEFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATL
                     IKYAGGFEADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYTMRNGDVVTAEAILNRFTNK
                     LEIRGAVYRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDI
                     RSIMDGTSPNLALMKNDILYIPSIHDLEDRGNVTVYGEVAQPDSYPYADNMTLEDLIIQ
                     AGGLKEAASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILQPYDEV
                     YVRRSPGYQAQQNVVIDGEILFGGNYAMTNREERLSDLVNKAGGPTNLAYLRGAKLTRV
                     ASAGEKKRMGDVIRLMSRQLGEAMIDSLGIGVEDTFTVGIDLEKALTNPKGSADLVLRE
                     GDVVFIPKNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGYSDNARKSKKFIVYMNG
                     QVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             2446..3594
                     /locus_tag="ctg104_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3658..4377
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg104_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.5e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             4398..5699
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg104_4"
                     /sec_met_domain="CTP_transf_like (E-value: 4.3e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 4.4e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 5e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5716..6840
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg104_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             6850..7971
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg104_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg104_6"
                     /sec_met_domain="Aminotran_5 (E-value: 3.3e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        6940..7947
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg104_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg104_6_Aminotran_5.1"
                     /locus_tag="ctg104_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             7968..8111
                     /locus_tag="ctg104_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             8350..9798
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg104_8"
                     /sec_met_domain="Polysacc_synt (E-value: 3.3e-31, bitscore:
                     99.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWSAIERFSLQGVQFIIQIILARLLLPSDYGMIGMLAIFLQVAQV
                     FIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIADFYNMPTLVLVI
                     RFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWMAYVGCGVWALVW
                     QTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLINTVYRNLYTIVIG
                     KKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCLTNAYRNYIRLSS
                     YIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQINLNLLWVKGRS
                     DLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYYTNSLIDLTLKLQ
                     VKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLSFLFKLDSFFCIL
                     TLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9752..11011
                     /locus_tag="ctg104_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             11020..11769
                     /locus_tag="ctg104_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             11769..12809
                     /locus_tag="ctg104_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 aactgaaact tttttatttg tcaatgaaaa tacaaagact ttttagcatt ctactatttt
       61 gtttgatgct gggaagtggc tcgcttatgg ctcagtccat gagtgactca caggtactgg
      121 aatatgtaaa agacggcatc cgccaaggca aggaacagaa gcagcttgct tccgaactag
      181 cccgtaaggg tgtaaccaaa gaacaggcaa tgcgtgtgaa gcagctatac gagcagcaga
      241 acaatgtaaa tacctcgaaa tcaacgggca cggacatcaa cgaatcccgc ctgcgtgaag
      301 agactaagaa gaatacttcc gatatgctgg aggatcatcc gactactcag gaccttgccc
      361 gtggtgatca ggtcttcgga cgtaacatct tcaatacccg caacctgacg ttcgagccta
      421 gtgtcaacct tgccactcct gccaattacc gtcttggtcc cggtgatgaa gtcatcattg
      481 atatctgggg tgcgagccag aacacgatcc gccagcaaat ctctcctgaa ggtactatca
      541 acattcagaa gatcggccct gtcaacctta gcggtatgac agtctctgcc gccaatgact
      601 atctgaagaa cgccctgaat aaaatatata acggtctgaa taatactacc gatcctactt
      661 ccgacatccg tctgacgtta ggtaatatcc gtactattca gattaatgtg atgggagaag
      721 tcgtacagcc cggtacctac gccctttctt ccttctctac cgtcttccat gcgctttatc
      781 gtgcaggcgg tgtgagtgat atcggtagcc tccgaaacgt tcagttggta cgcaacggaa
      841 agaatattgc caccatcgac gtctacgaat tcattatgaa aggcaacaca caggatgaca
      901 tccgcctaca ggaaggtgac gttgtgattg ttcctgccta tgatgtattg gtaaagatta
      961 gcggcaaggt aaaacgtcct atgcgttttg aaatgaagaa agacgagaac cttgctactc
     1021 tcatcaaata tgccggcggc tttgaagctg acgcctacac ccgttcatta cgtgttgtcc
     1081 gtcagaatgg tgaggaatac gaagtcaaca cagtcaagga tatggactat agcatctaca
     1141 caatgcgtaa cggtgacgtt gtaacagccg aagccatcct taaccgcttc acaaacaaac
     1201 tggaaatccg tggcgctgtc tatcgtcccg gcatctacca gctcagcggt aaactgaata
     1261 cgatccgcga acttgtccat gaagcccagg gcctgaccgg tgacgctttc ctgaatcgtg
     1321 ccgtccttta tcgccagcgt gaggatttga ccagtgaagt tgttcagata gacatcaggt
     1381 ctatcatgga cggtacttcc ccgaacctcg ccctgatgaa gaatgacatc ctttacattc
     1441 cgagcattca cgatctggaa gatcgtggca atgttacagt ttacggtgag gtcgcccaac
     1501 cggattccta tccctatgct gataacatga cacttgagga tctgatcatt caggccggtg
     1561 gcttgaaaga agccgcctcc actgtccgca ttgatgtgtc gagacgaatc aagaatcccc
     1621 gtagtaccgc ggataatgat actatcggtc agatgtatac cttctcttta aaggatggtt
     1681 ttgtaataga tggtcagccc ggttttatcc ttcagcctta tgatgaagtt tatgtccgtc
     1741 gcagtccggg ttatcaggca caacagaatg tagtcattga tggtgaaatc cttttcggag
     1801 gaaattacgc catgaccaac cgtgaggaac gtctttccga tctggtgaat aaagcgggtg
     1861 gtcctactaa ccttgcctat cttcgtggtg cgaaattgac ccgtgtggca agtgccggtg
     1921 agaagaaacg tatgggtgat gtgattcgct tgatgagcag gcaattgggt gaggccatga
     1981 ttgactcttt gggtattggt gttgaggata cctttacggt aggcattgat ctggagaagg
     2041 ctttgactaa tcctaagggt agtgccgacc ttgtcctacg tgaaggtgat gtggtcttca
     2101 taccaaagaa tactaatact gtaactatca atggtgctgt catggttccg aatacggttt
     2161 cttatatgaa gggcaagaat gtggattatt acctgaatca ggccggtggc tattctgata
     2221 atgcaaggaa gagtaagaaa ttcattgttt acatgaatgg tcaggtgacg aaggttaagg
     2281 gtagtggtaa gaaacagatt gagccggggt gtgagattat tgtgcctggt aaggctaaga
     2341 agaaagggaa catagctaat attttaggtt atgctacttc cttcagttct ttgggaatga
     2401 tgattgcttc tattgctaat ttgataaaga aataaatgac ctattatgat tgaaaagcaa
     2461 tcttatcaag aaccgttttc tgaagtggat aaaaggaaag atgatgaaat ggaaatagac
     2521 ttgatggcta ttttttataa gattattact gttcgtggag tactatgcaa agctgctgga
     2581 gtgggagtaa taattgctat agtggtggca ttgagcattc ccaagcaata tacagtaaag
     2641 gttacccttt ctcctgaaat gggtaatgcg aagggaagta atggtttagc cggacttgct
     2701 gcctcgtttt tgggagatgg ggctctaata ggggaaagca cagatgcctt gaacgcttct
     2761 ctttcagcag atattgtttc ttcaactcct tttttattgg aacttttaga aatggaagtc
     2821 tccgtttcta aaaaggatga taaaatgact ttggggtctt atctcgatga agagtcatct
     2881 ccttggtggg attatcttat aggttttccg ggcatagtaa taggaggagt taaatcatta
     2941 ttcggagaag atacggttcc tgccagtgga gggcggcaag gaactatcga attgacgaaa
     3001 gaagtaaatg agaagattaa ttttcttaaa aagaagatta gtgcatccat tgataagaaa
     3061 accgccataa cgagcattac ggtcacctta caaaatccgc agatcactgc ggttatagca
     3121 gattctgtcg ttcataaatt acaggaatat attattgggt atcgaacttc aaaagtaaaa
     3181 gaagactgtg cgtatttgga acggttgttt aaagaacgtc agcaggaata ttatgctgct
     3241 caaagaaaat atgcggatta tgtagacgcc catgataatg tggttcttca aagtgtacgt
     3301 gctgagcagg agcgtttaca gaacgacatg agtttggctt atcagatata tagtcaggtt
     3361 gctaatcagt tgcaggtatc cagagccaaa gtacaggagg aaaagccagt ctttgcagta
     3421 gttgagcctg ccgttgtacc tttgaaacct tcaggtatgg gactcaaaat ttatatttta
     3481 ttatttgtgt tcctgtccgt atctggtact ctcgtgtggg tgttttttgg caaaagtctg
     3541 ctggctagct tgagaaaaga actgaaaaat aaggagatag aacaggataa atgatgctaa
     3601 aacgtcgttt acaacattct tacatcaatt aaattcactt actatattat taaacgaatg
     3661 atacgtacag ctatgataat ggctgcgggc atgggaaccc gttttggcca atatacagaa
     3721 ttgataccta aagggttcgt caaagtggga ggtattccaa tgatagttcg ttctattgat
     3781 actttgttat catgtgacat tgagcgaatt gtaatcggta caggatataa acaagaagtt
     3841 tatgaagaat tgaagacaga ctatcctatg cttgaaacct gttttagtcc tcgttatgct
     3901 gaaacaaata gtatgtatac tttatataat acgcgggaga ttctgggcaa tgatgatttt
     3961 ttattgttag agtcagattt gatttttgag aaacaagcaa taatgagctt attggagtgt
     4021 cctgcggcag atgcaatgct aataactcca gtgacaaagt ttcaagatca gtattatgtg
     4081 gaacatgatg ataattttcg cctttcttca tgttctgtca ataagaataa actaaacgct
     4141 aaaggcgaat tggtcggcat ccataaacta tccggttcct tttacaaaat aatgtgtgct
     4201 gattatgcga gtattgttga tgaacaaccc aatttgggat atgagtatga attactacga
     4261 atatcttgtt ctcaatctcc tgtttatgtg cataaagtag aagggctgaa atggtatgaa
     4321 atcgatgaca tatcagattt ggaatatgca gagaaatata ttgttccgta ttgttaatta
     4381 aaataatata tcaaattatg agtaagacag tttatattgg gatgactgcg gatattatgc
     4441 atccaggact tatccgcatt attaatgagg ctactaaata cggtgatgtt ataattggtc
     4501 ttcttacaga taaagctatt gcggagcata aacgccttcc ttatctgacc tatgaacaac
     4561 gaaaagaggt agttcagaat attaaaggcg tatgtaaagt tgttcctcaa gaagaatgga
     4621 gctatgttga gaatctcaaa cgcattaaac ctgactatat aattcatggt gacgactgga
     4681 aaaccgggcc tttacgtgaa gaacgtgtgc gcgtatttga agtgatgaat gaacagggag
     4741 gaaaggttat cgaaattcca tatactttgg gaattaattc atcttctttg gataaagata
     4801 ttaaggctat aggtacaacc cctgatgtac gtttaaaatc acttcgtcgt ttgataaatg
     4861 ccaaacccgt agttcgtatt ttggaagctc atgatggact atgtggcttg ataattgaaa
     4921 atcaggaaat attaaaaggg gataagaggg aagtatttga cggaatgtgg tctagtagcc
     4981 ttacggattc aaccagtaaa ggtaaacctg atattgaggc ggttgattta actacccgat
     5041 tgcaagattt gaataatatt ctggagtgta ctactaaacc tattattttt gatggagata
     5101 caggtggtaa aattgaacat ttcgtattta cagtacgcac tttagaacgt catggaattt
     5161 cagctataat aattgaagat aaagttggat taaaaaagaa ttcattgttt ggtacagatg
     5221 ttattcaaac tcaagataca atcgaaggtt tctgtaataa gatcaaagca ggaaaggcat
     5281 ctcagattac tgatgatttt atgattatcg ctcgtattga gagccttata gcgggaaagc
     5341 cggtaagtga tgctttagag agagcttttg catatgtcca agcgggagcg gacggtatta
     5401 tgatacatag caaaaataag tcgggtgaag atataaaaga attttgtttg gcgtttcgaa
     5461 aacagtatgc tcatgtacct atcgtggttg tgcctactac atatgatcat atttatgagt
     5521 ctgaattgtg tgattggggt gtgaatataa ttatttatgc taatcatatg cttcgtgccg
     5581 cttatcctgc tatgatgaat gtcgcaaaga taatattaga gaatgaacgt gctttagagg
     5641 tgcgcgaact gtgtatgccc ataaaagaaa tattggaact gattccaggt actaaataaa
     5701 aagaggaata tcattatgtt aagcgtagaa aaagtttatg aaacgtttct gagtcatgac
     5761 gttgattttt ttacaggagt tccagactca ttactaaaaa atatttgtgc ctatatcaca
     5821 gaccatactt cacgtgagaa acatatcata gctgctaatg aaggtgcggc tgtaggaatt
     5881 gcttcaggtt attatatggc atcaggtaag gttcctgtgg tttatatgca aaattccggc
     5941 ttgggtaata ctgttaatcc tctgctgtct cttgcagatg aacaagtata cagttttcca
     6001 atgcttttga tgattggctg gcgtggtgaa ccgggaacaa aagatgaacc tcagcataaa
     6061 aaacagggtg aggtaacttt agatttgttg aaagcaatgc ggattcctta tataattctt
     6121 gattcaaatg agaatgatgc atttattcag ctccatgata tcatacaatc agcaaaaact
     6181 aagaatattc ctcatgcaat aattattcgg aaagatgttt ttggcaaata taaacttcaa
     6241 aaagagttcg gatgtaatta tcctttatct cgtgaggatg ctttgcaaat agttgtggat
     6301 tatctgcctg aaaattcagt ggtcgtttct actactggca agctttctcg tgagttattt
     6361 gaatatcgag aaatgaaaga gcaaggtcat gaacatgatt ttctcacggt aggctctatg
     6421 ggacatagtt catcaatctc tttgggtatt gctatagcaa agcaagatag acctgtttat
     6481 tgcttggatg gtgatggagc atttattatg catttagggg caattagtaa cattggcgat
     6541 ttatctccta aaaactatta tcatattttg tttaacaatg gtgctcacga gtctgtagga
     6601 ggacagccta ctttaggatt tagtttagat attccggcta ttgtccgggg gagcggatat
     6661 aagcatactt atactgtttg tacaaaagtt gaaattgaag aagcaatgaa gcagcttcca
     6721 aagttatgtg gtcctgtttt gttggaaata aaggttaaaa tagattctcg ggagaatttg
     6781 ggacgtccca cgactactcc tatagagaat aaggagcatt ttatggattt tttaaaataa
     6841 atatattcga tgaaaataga aagaaaaata ttattaaatc ctgggcctgc cactactact
     6901 gacagtgtaa aaatggcaca agttgttccg gatatttgtc ctcgcgagaa agaattcgca
     6961 ggtatgatga aacaacttcg ggacgatttg gtcagagttg ctcatgggaa tttggaaaaa
     7021 cataccgctg tattattttg tggctcagga accatcaata ttgatatatg tctaaattct
     7081 cttcttcctg aagacaaaag ggtgcttata gtgaataatg gggcatatag tacccgtgct
     7141 gtagaagtgt gtcaatatta tggtttgcct catattaatt tggaattttc cgtttacgaa
     7201 cgtcctgatt tatcggtggt ggaaaatgtg ttgcaagaaa atcctgatat agctatggtt
     7261 tatactactc atcacgagac gggtacagga attctgaacc ctattcgcga gatgggcgct
     7321 atagctcata aatatcaggc taaatttgtc gtcgatacta cttcttcttt gggcatgatt
     7381 ccttttgata tagagaaaga taatgtggat ttttgtatgg catctgctca aaaaggactt
     7441 caagcgatga caggtctttc ttttattata ggcaatgagg aacagattaa gttttcaaaa
     7501 aaatatccca agcgttctta ctattgtaat ctttatttgc agtatgagaa ttttgagaga
     7561 acaggtgaaa tgcattttac tccaccggta caaactattt acgccactcg tcaggcatta
     7621 aatgaatatt ttgaagtggg tgaagaagct aagtttgccc gtcacaaaag agtttttgag
     7681 gctattcatt caggtataaa tgaaattggt cttaaaagtg taataaagcg tgaatggcag
     7741 tcaggactgg ttgtctcagt tcaataccca gaagatccca actgggattt tgagaaaata
     7801 catgattatt gttatgagcg tggatttacg atttatccag gtaagatatc aactgaggat
     7861 acttttagaa tctgtgcttt aggagagata gaagtagatg atattgagaa cttctttaaa
     7921 gtactaaaag ctgcattaaa tcattataac gtcacattac cgatgtcatg attgcagaaa
     7981 tattattgaa gattcgtcat ttttattttt cccttcgtgg tatacacttc catccggaaa
     8041 gtgttatttc tggagtgcct attcgtagct ttcgcttagt aggcaaatat ggcaatatta
     8101 atttgaggtg atgcattagg agttctttat tcttataaaa aggcatcggt agttatagga
     8161 gataatgttt gtgtagggta atttgctttt agtgggagag accatattag aattgcggta
     8221 aggggcgaag aagataataa ccaattagtg agaatattgg aaaaatataa ttgatatcgg
     8281 taaatgtagt tgtttttata ctgtatttaa gtaatggaaa atctaaagca gaaaactgta
     8341 tcaggaataa tgtggagcgc tatagaacgt ttctctttac aaggagtaca gtttataatt
     8401 caaataatat tagctcgttt gttactacca tcggattatg gtatgatcgg gatgttagct
     8461 atttttcttc aagtcgctca agtatttata gatagcggtt ttacaaatgc tttaatccag
     8521 aaaaaagata gaactgaaga ggattttgcc actgtctttt attttaatat tcttgtcgca
     8581 gtattattct atggtatatt gtttttttcg gcttctttga ttgcagactt ttataatatg
     8641 ccgactttag ttcttgtaat tcgttttata gcattgtcgt tgataataaa tgctttatcg
     8701 gctattcaca gaacgaaatt aattatttct gtaaacttta aaactcaatc taaaatttca
     8761 ttaggtgcag cttttatatc aggcgtgatt ggaatatgga tggcttatgt cggttgcggg
     8821 gtttgggctt tagtttggca aactctctta aatagtataa ttttgacaat tttgttttac
     8881 tgtttagttc attggaaacc tttacatact ttctccaaaa gttcttttga aagattattc
     8941 aatttcggat ctaaattatt gatctcaagt cttatcaata cagtatatcg taatctgtat
     9001 accattgtaa taggaaaaaa gttttctgtt gtagagcttg gttactatac aagagcagaa
     9061 caatttgcta tttttccttc caataattta aatgctttag tttctagagt agcgtatcct
     9121 attttaagtt ccattcaaga tgatgataaa tgtttaacaa acgcatatcg aaattatatc
     9181 agattatcct catatataat ttttccttta atggtaggtt tacttgtttt ggctaatcct
     9241 attattagtc tattgttaac agataaatgg tctggggttg ttattctttt acagatatta
     9301 tgtttggatt ggatgtttga tcatttgagc caaattaatt tgaatttatt atgggttaaa
     9361 ggaagatctg atctgtcgtt acgtcttgaa ataataaaaa agacgattgc tatattcatt
     9421 ctttttgtgt caattccatt tgggcttgag gtgatgtgtt ggggtagagt tatttactct
     9481 ctgatagcga catatttgaa tacatattat actaattctc ttattgattt gaccttaaag
     9541 ttgcaagtta aagatgtatt tccaagttta atactctctt tcataatggg ggggatcgtt
     9601 tttatatgta tttctttctt tgaaactgat atagtaaaaa ttgtgattgg atgtattact
     9661 gggatgtcct tctatatttt actttctttt ctttttaagc tagattcttt tttttgtatt
     9721 ttaacattga tcattaaaac taaaaacata gatgaaaata ttaaaaaaga tttttcaagt
     9781 aatagtaaag ataattaacc attgtgtgcc agttgatagt agatcattgt attttattcc
     9841 tcatcctaat tgtagaacag ataaatatga tattataaat tattcgtcag ataatgttct
     9901 cgttctgtta aattatttgc taaaaaaaga tagtgctgaa tattataaaa tatatgttga
     9961 aatttatgat tcttctcgta tttcagaata tcaagaatat atttatggca taaatcctaa
    10021 tattaggtgt acttttttat gtgcatgtgt tggacgtttt ttctttaata aagtatcttt
    10081 taaggatatg ttgtatgcct ttttttgttt ttgtagagca agtaaatgtt ttacagctac
    10141 tttttattat gatttttcat ttaaaaaacg ctctcaacag attatttgtt tggggtatta
    10201 tactccattc aaagatgatt atcatatggg agatcattct tatgataaat ttcgtaatac
    10261 aacatgtaac tcatttgatt actctattgc tacttcttgt ttaagtgcta gaataatttc
    10321 aatagattgt ggaatctcat atgataaatt caaagtctta ggatttccca gaaatgattt
    10381 gttgatatcg aaaaataatt gcaatgttat taaaagagaa atttcgaaat ttgcgggata
    10441 tgatgtaact aaatatatag tttatactcc aacttttcgt gattatgaga ctgttactga
    10501 aggtaatttg cgttcaatac tcggatatgt tgattgtgat ttgttgaagt tatcgaaaat
    10561 actattgaag tttaatgcgg ctttaattct taaattacat cctttgcaga ataaaacagt
    10621 cttaaaaaaa gatttaccca aaggtatact tgtttttgaa caaacatata aatatggatt
    10681 gtatgatctt ttgtcatttt cagatggaat gattactgat tatacttcta cctattttga
    10741 ttttttattg gtaaataagc cagtcatatt taatttctac gatattgaag aatatcgtag
    10801 agtaagaggt ttctcatttg agccaataga atttttttgt gcaggtgata ttgtttacaa
    10861 ttataatgaa ttgatagatg ctgtgatggg acttctggct gggaaagata ttcatgctga
    10921 acatcgacgt catatttctt tattgatgaa tcaatttcaa gatgataatt caacaaagag
    10981 aatatgtgac atatttttaa atgaaatata ataaataaaa tgaattatgc atttgtggtg
    11041 caggcacgtt taggttctac acgtttgcct ggaaaaatat tgaaaccttt ctatggtaat
    11101 caatcgattc ttgacttaat ggttcataag ctttctgcta tatcgaatat tccagtaatt
    11161 attgctacaa caaattctgt tatcaatgaa cctattgaaa agaaggcact tgcattaggg
    11221 gtaaagtgct tcagaggtga ggagaatgat gttttaaaac gattcattga tgttgctgaa
    11281 tattttgata tacagggtat attccgaata tgttctgata atccattttt agatgtacat
    11341 gcggcaaggc aattggtcga aatagcaatg aaatcttgta acgattatat aagttttgat
    11401 attgatggta ctccatcaat taaaactcat ttcggttttt ggggagaatt tgtaacgctt
    11461 gatgcgctga agcgagttat aggatttact gatgatttat tgtatcgtga acatgttact
    11521 aattatatat atagtcatcc tgaacttttt aatattcaat ggatttcagg atctccagtc
    11581 gtgtcaaaac atcataatat tcgactcacg attgatacgt tagaagattt ttctgtagca
    11641 cagagaatat atagggattt acaagaaaaa agagtggaaa tatcgataga agtgattgta
    11701 gactatgttc gaagacatgc agaatacatt caactgatga aacaacaaat aaaaaaaaat
    11761 tctaaataat gaagaatact tatattattg gtgaaatagg gcagaatcat aatggttctg
    11821 ttgacttggc taagttgatt attgaattaa tctcacgacc tgtacatgag gatgtttttg
    11881 gtatggattt catgccaatg aatgctgtta aaatgactaa aagagattta tcagaagaat
    11941 tggctgtttc tcaaatgaat caaatatatg acaatcctaa ttcttttggg cgtacttatg
    12001 gtgaacatcg tgcttttctt gagcttgatg atcaagcgca ttttgagatt tataaatatg
    12061 ctaagtcatt aggattagat tttatcgaga cgttatgtgc caaaggatgt ctgtctttgc
    12121 ttaaactgtt cacaccggat aggctaaaag ttgctagtcg tgatttgact aacttaccat
    12181 tgcttgaagc attagcagaa actcatattc ctattatatt atcgacagga atggctggtc
    12241 aaagagaact tgacaatgca ttagatgtga taacgagata tcatagtaat atagctattc
    12301 tacattgtgt atctcagtat ccaactcatc caaataattt gaatctacgt acaataacat
    12361 atttgaagaa gcattacaat aagtttgaga taggtttttc tgatcataca ataggtattt
    12421 ctgctgctac agctgctgta gcgatgggag cggaaattat agaaaagcat gtaacaattg
    12481 atcggcatat gaaaggaaca gaccagcttg gctctttagg tccagatggg gttaatcgta
    12541 tgattcgaga tattcgcata gcagagtgtt ggcttggtac tgaagatctt tatatagaaa
    12601 aaggggtgga gaagtctaag ataaaacttg aacgttctat tgccactcga aaatatattc
    12661 cagcaggtag tattattcaa gagtcggaca ttcatttact gagtcctggt gatggttata
    12721 aatggataga taaaaaaaat gtaattggtc attttgctaa acaagatata tcagcgaatg
    12781 aaataatata tcctgatttt attgaataga tatattccta ctgcaacttg tattacggta
    12841 tagagtactg cctgctataa gctaagtagt gattaataaa taagggtaaa atactaaaaa
    12901 aatgaaagag ataaagctta tacttacaga tattgatggc gtttggactg atggcggaat
    12961 gttttatgat c
//
