LOCUS       c00072_gnlPro..        13492 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JDMHGBGP_72.
ACCESSION   c00072_gnlPro..
VERSION     c00072_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 21:30:59
            Original ID  :: gnl|Prokka|JDMHGBGP_72
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13492
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13492
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3492]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..3492
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13492
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13492
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             3..683
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_1"
                     /sec_met_domain="SucD_FumR (E-value: 1.4e-130, bitscore:
                     425.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GRKVVMSVTGIALVLFLTFHMAMNLVAIISADGYNMICEFLGANW
                     YALVATAALAALFIIHIIYAFWLTMQNRTARGSERYAVVDKPKTVEWASQNMLVLGIIV
                     IVGLGLHLFNFWAKMQLPELMHNLDMHADTLTLAYAANGAYHIQQTFSCPVYVVLYLIW
                     LFALWFHLTHGFWSSMQSLGWNNKVWINRWKCISNIYSTIVVLGFALVVVVFFVKSLLC
                     GGAC"
     CDS             721..2700
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 200.6; E-value:
                     1.5e-61)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_2"
                     /sec_met_domain="FAD_binding_2 (E-value: 3e-61, bitscore:
                     200.6, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 6.5e-36,
                     bitscore: 116.1, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKIDSKIPEGPVAEKWTNYKAHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLGEMGFRVFNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKG
                     GDYRAREANVYRLAEVSNAIIDQCVAQGVPFAREYGGTLDNRSFGGAQVSRTFYAKGQT
                     GQQLLLGAYSALSRQVNVGTVKLFTRYEMQDVVIIDGRARGIIAKNLITGELERFAAHA
                     VVIATGGYGNAYFLSTNAMGCNCTAAISCYRKGAVFANPAYVQIHPTCIPVHGDKQSKL
                     TLMSESLRNDGRIWVPKKKEDAIKLQKGEIKGSDIPEEDRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNNTGLAVFLDFSEAINRLGIDVVLQRYGNLFDMYEEITDVNPGE
                     LAKEISGVKYYNPMMIYPAIHYTMGGIWVDYELQTTIKGLFAIGECNFSDHGANRLGAS
                     ALMQGLADGYFVLPYTIQNYLADQITVPRFSTDLPEFAEAEKAVQAKIDKFMSIQGKES
                     VDSIHKKLGHIMWEYVGMGRTAEGLKKGIAELKAVRKEFETNLFIPGSKEGMNVELDKA
                     IRLYDFITMGELVAYDALNRNESCGGHFREEYQTEEGEAKRDDENFFYVACWEYQGDDE
                     KAPVLIKEPLVYEAIKVQTRNYKS"
     CDS             2737..3492
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_3"
                     /sec_met_domain="Fer4_7 (E-value: 8.9e-12, bitscore: 38.5,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 6.3e-25, bitscore: 80.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.9e-06, bitscore: 20.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQAGPKAKGAFETYQMKDIPGDTSFLEMLDILN
                     EQLISERKEPVVFDHDCREGICGMCSLYINGHPHGPATGATTCQIYMRRFNDGDTITVE
                     PWRSAGFPVIKDLMVDRTAYDKIMQAGGYVSVRTGAPQDANAILIPKPIADEAMDAASC
                     IGCGACVAACKNGSAMLFVSAKVSQLNLLPQGKPEALRRAKAMLSKMDELGFGNCTNTR
                     ACEAECPKNISISNIARLNRDFIIAKLKD"
     CDS             complement(3600..3992)
                     /locus_tag="ctg72_4"
                     /transl_table=11
                     /translation="MDTLNLHSNFDNLLYIGRSVLNNTSSHIQKLFFKKEMCIYEYLYK
                     EEVSKGIEIKIDDVVLVCALEHDKCNKSILYFNDVANIARYIHYCNSNFEYKEELNGWI
                     MSDSYLALSISEDDYEKRFAFIQTLL"
     CDS             4118..4342
                     /locus_tag="ctg72_5"
                     /transl_table=11
                     /translation="MTEIMLDKQETLNEIGTKIRKLRESKNLSIQEFADKLEMEYNNVI
                     RIEKGRTNFTIGTLVKIANSLEVNLKDIV"
     CDS             complement(4520..6046)
                     /locus_tag="ctg72_6"
                     /transl_table=11
                     /translation="MRTKRAFKEFCVLGGLASSVCGVAQERPNIIVFLVDDMGLMDTSV
                     PFIADESGQPVRHPLNDWYHTPNMERLAKQGICFSTFYAQSVSSPSRASIMTGQNATRH
                     GVTNWINAESNNRNPFGPPQWNWKGLRKDMPTMPRVLQQAGYKTIHVGKAHFGCMGSEG
                     ENPLNIGFDVNIAGSGIGHPGSYYGEWGYGHIKGQKIRAVPDLEKYHGTDTFLSEALTI
                     EANREITKAVEEKRPFYLNMAHYAVHSPFQADKRFLSRYTDPDKNEQARAFATLIEGMD
                     KSLGDIMDQLEKLGIAENTLILFLGDNGGDAPLGDERGYGSSAPLRGKKGTEFEGGMRV
                     PFIAAWAKPEKKSKVQKNLPIEVGSMQTQLGTIMDIYPTVLSVAGCEVPQNYVIDGFDL
                     KKQLSGKVDKKRPESFLMHFPHAHRGSYFTTYRMGDWKLIYYYLPETPKQPKALLYNLK
                     DDPEERNELSSAHPDKCREMIQEMSAQLEKEGALYPVDKQGNELKPFVYF"
     CDS             complement(6386..7228)
                     /locus_tag="ctg72_7"
                     /transl_table=11
                     /translation="MSSICQGTWDCQNCPKAVDNAIIHTTHTRGYHQPARKCEDNFILF
                     LIKGELLVNSQEYAGTMLKAGEFILQAIGSKYEMLAMTECECIYYRFIQPELFCDFRFN
                     HIMKDVPSPLIYSPLKIIPELKYFLDGSKSYLSESKVCRDLLSLKRKELAFVLSYYYSD
                     YDLASLVHPLSKYTTTFEYFILQNYKKVKTVEELAQLGGYTVSTLRRIFNNVFHEPVYE
                     WMQARRKEGILDDLNNSEYSISEICYKYGFESLPHFSNFCKKFFGASPRMLRTSKKNV"
     CDS             complement(7423..8400)
                     /locus_tag="ctg72_8"
                     /transl_table=11
                     /translation="MKKVLLAIAAVATITSCSQNEDFDNLGQKAEINFSTAVTRATVLD
                     TKGLQNAGFQVYAYNTGTAGMDITTVLPSSAWITGKATYAASAWSVAGGPYYWPLTDKL
                     QFFAYSPLDGVTYTDPNGTAAGYPQFTYNVGLTASTQKDLVISSELDKTKETDKATPAV
                     SLTFKHALTQINIQVIEGNADYTYELTEADAVIISGVKSDGTFTYAGANTGSWAVGNTD
                     ATYTYTLGAFVDGTSTVVAGNALMLIPQDITNAKITIKYKTKKGESYVFNDKKEIPLKS
                     TTPWAFGTKILYKLTLPVGGEEVKIEATPADWNTEIPETTEPSV"
     CDS             complement(8453..9409)
                     /locus_tag="ctg72_9"
                     /transl_table=11
                     /translation="MQDTRYILLVLLSSLLMLTGCSRRELLDDYPVSGVDIKLDWNGVT
                     DKLPEGVRVIFYPKSAEGRKIDTYLSVRGGKVKVPPGRYSVVAYNYDTETVQIRGEEAY
                     ETIEAFTGYCNGLGIAGTEKMVWGPDPLYVVQIDDLHIANSEEELLLDWKPKLVVKTYS
                     FKIKVEGLEYVSSIVGCVEGMAGCYCLGRCCGMMNDAPIYFEAQGRSGEVTGSFTAFGL
                     PEGAMSRASLAIKFTLAFVKVDNTVQKIEVDITDVIVNSESGEGGGNDEPSKDIELPLD
                     DDEVKVDKPENSSGGDGGIGGDVGDWGEEEEVPLPVI"
     CDS             complement(9417..10694)
                     /locus_tag="ctg72_10"
                     /transl_table=11
                     /translation="MKHGIYTCVILMAFLALSESVYAVVPVFTIASDTIRRVVIYFDQE
                     ETDVDSCYKTNNQEINVLDSLLEERINSRYITALNVVTFVSPDGDSVYNAALSVRRNNS
                     MREFLRQRYPYVDVEKIKLTSEGEDWSELRKLVASDSDLPDREEVLMLIDYHRDNIVKR
                     KELLQKLNQGMAYRYIVRNVLPKLRRAEITVVRKVPEMEKNIFEPVSSVSGLFVSKQEE
                     ALPSDQPDKPEGESKESMAYEVVVSEAEGPVESKTVLAVKNNLLYDLALAPNLEVEIPV
                     GKRWSLNAEYKCPWWLNSKHNFCYQLLSGGVEGRCWLGNRQKRNRLTGHFVGLYAEGGI
                     YDFQWKGDGYRGDYYGAAGVTYGYARQLARHLSLEFSFGIGYLTTEYKKYTPYEGDIVW
                     TTSGRYNFIGPTKAKVSLVWLIKRGR"
     CDS             complement(10966..11463)
                     /locus_tag="ctg72_11"
                     /transl_table=11
                     /translation="MALEYVVTKRVFGFDKDKNEKYVAKSVRSGRVSFSKMCGKVSRLC
                     GVHRKVVDLVVSGLVDMMAEDIDDGKSVQMGEFGIFSPTIRAKSADDEKEVSSKSIVQR
                     KILFYPGKIFKTTLDDMSITRRAELDTDYTDGSSNNGSGSVKPNPGGDGGKGDEEAPDP
                     TV"
     CDS             complement(11824..11949)
                     /locus_tag="ctg72_12"
                     /transl_table=11
                     /translation="MRKHTFLFIIFLYVGICIQVKATDQRGEYLVIGKDTLEMFT"
     CDS             complement(12423..12644)
                     /locus_tag="ctg72_13"
                     /transl_table=11
                     /translation="MRGILSFAALAAMYFPGCTTSKNAVHCLSRWIKGCNPLVKELIPT
                     GYLPYNHRFLTSKQYKIITKHLGDPYED"
ORIGIN
        1 taggaaggaa agtggtgatg agcgttaccg gtatcgccct tgtcctgttt ctaacatttc
       61 acatggcgat gaacttagtt gcaatcatct cggctgatgg ttacaacatg atttgtgagt
      121 ttttgggagc aaactggtat gcgctggtag ctaccgcagc actggctgct cttttcatta
      181 ttcacatcat ctacgcgttc tggctgacaa tgcagaatcg cacagcgcgc ggtagcgaac
      241 gctatgcagt agtcgacaaa ccgaaaactg tagagtgggc ttctcaaaac atgttggtgt
      301 taggcattat cgttatcgta ggcctcggtt tgcacctctt caacttctgg gcaaaaatgc
      361 agttgccgga actgatgcac aacctggaca tgcacgctga tacactgacg ctggcttatg
      421 cggcaaacgg tgcatatcac atccagcaga cattctcttg tccggtttat gtagtgctct
      481 acctcatttg gctgtttgct ttgtggttcc acctgactca cggtttctgg agctccatgc
      541 aatcactggg atggaacaac aaggtatgga tcaatcgttg gaaatgtatt tctaacatct
      601 attctacgat tgtagtactc ggtttcgcac tcgtagtagt ggtattcttc gtgaaatcac
      661 tcctttgtgg cggtgcttgc taaatagtaa attgtaaatg attaaattgt aaataatatt
      721 atgatcaaga tagattcaaa aattccagaa ggcccggtgg ctgagaaatg gaccaactat
      781 aaagctcacc agaaattggt gaaccccgct aataaacgcc gtttggatat catcgttgtg
      841 ggtacgggtc tggcaggtgc ttctgctgct gcatccctcg gtgaaatggg tttcagagta
      901 ttcaacttct gtattcagga ctctccgcgc cgtgcacact ctatcgctgc acagggtggt
      961 atcaatgctg caaagaatta tcagaatgat ggtgactccg tttaccgtct gttttacgat
     1021 acagtaaaag gtggtgacta tcgtgcacgt gaagccaacg tttaccgtct ggccgaagta
     1081 tccaacgcta tcatcgacca atgcgtggca caaggtgttc ctttcgcacg cgaatacggc
     1141 ggtacactgg acaaccgttc tttcggtggt gcacaggtat cacgtacgtt ctacgctaaa
     1201 ggccagaccg gtcagcagct gttgctgggt gcttactccg cactaagccg tcaggtaaac
     1261 gtaggtacgg tgaagctgtt cacccgttat gaaatgcagg acgttgtaat catcgacgga
     1321 cgtgctcgcg gtatcattgc caagaactta atcaccggcg aactagaacg tttcgctgct
     1381 cacgccgtag taatcgctac cggtggttac ggtaacgctt acttcctgtc taccaacgct
     1441 atgggttgta actgtacagc tgctatctct tgctaccgca agggtgctgt attcgctaac
     1501 cccgcatacg ttcagattca cccgacttgt atcccggtac acggtgacaa gcagtccaaa
     1561 ctgactctga tgtccgaatc tctgcgtaac gacggtcgta tctgggttcc gaagaagaaa
     1621 gaagacgcta tcaaattgca gaaaggcgaa atcaagggaa gcgatattcc tgaagaagac
     1681 cgcgactact acctggaacg ccgttatccg gcattcggta acctggttcc gcgtgacgtt
     1741 gccagccgtg cagctaaaga acgttgcgac gcaggtttcg gtgtgaacaa cacaggtctg
     1801 gccgtattcc tcgatttctc tgaagctatc aaccgcctgg gcatcgatgt agtgcttcag
     1861 cgttatggta acctcttcga catgtatgaa gaaatcactg acgttaatcc gggcgaactg
     1921 gcaaaagaaa tcagtggtgt gaaatattat aatccgatga tgatttatcc ggctatccac
     1981 tacacaatgg gtggtatctg ggtagactac gaactgcaga ctaccatcaa gggtctgttc
     2041 gctatcggtg aatgtaactt ctccgaccac ggtgcaaacc gcctcggtgc ttccgcattg
     2101 atgcaaggtc tggccgacgg ttacttcgta ttgccttaca ctatccagaa ctatctggca
     2161 gatcagatta ctgttcctcg tttctctact gaccttccgg aatttgccga agcagaaaag
     2221 gcagttcagg ctaagatcga caagttcatg agcatccagg gtaaagaatc agttgattct
     2281 atccacaaga aactgggtca catcatgtgg gaatacgtag gtatgggacg tacggcagaa
     2341 ggcctgaaga aaggtatcgc cgaactgaaa gcagtccgca aggaattcga aaccaatctg
     2401 tttatccccg gttctaagga aggtatgaac gtagagctcg acaaggctat ccgtctgtat
     2461 gacttcatca ctatgggcga gctcgttgct tacgacgcat tgaaccgtaa cgaaagttgt
     2521 ggtggtcact tccgtgaaga ataccagact gaagaaggag aagcaaaacg tgatgacgaa
     2581 aacttcttct acgtagcttg ctgggaatat cagggtgacg atgaaaaggc tcctgtattg
     2641 atcaaagaac cgctggtata cgaagctatc aaggttcaga cccgtaacta caagagctaa
     2701 tcggtgaagt taaacattta aaagaattag acgaaaatgg ataaaaatat atcatttaca
     2761 ctgaaggtat ggcgtcaagc aggcccgaag gctaaaggcg cttttgaaac ctaccaaatg
     2821 aaagatatcc ccggtgatac ttccttcctc gaaatgctgg atattctgaa cgaacagctg
     2881 atcagcgaaa gaaaagaacc ggttgtattc gaccacgact gccgcgaagg tatttgcggt
     2941 atgtgttctc tttacatcaa cggacatccg cacggtcctg caacaggtgc tactacttgc
     3001 cagatttaca tgcgtcgttt caacgatggt gacaccatca ctgttgagcc ttggcgttcg
     3061 gccggtttcc ctgtcatcaa ggacttgatg gtagaccgta ctgcttatga caagatcatg
     3121 caggccggtg gttatgtaag cgttcgtaca ggtgctccgc aggatgccaa cgctatcctg
     3181 atcccgaagc ccatcgctga cgaagctatg gatgccgctt cttgtatcgg ttgcggtgct
     3241 tgtgtagctg cttgtaagaa tggttctgcc atgttgttcg tttcggcaaa ggtcagccag
     3301 ttgaacttgc ttccgcaagg taaaccggaa gctctgcgcc gtgcgaaagc tatgttgtcc
     3361 aagatggacg aactcggatt cggtaactgt accaacaccc gcgcttgcga ggctgaatgt
     3421 ccgaagaaca tctctatcag caacatcgcc cgcctgaacc gcgacttcat catcgctaaa
     3481 ctgaaagact aagcgtgagc ttgatttgat taatagcata aatcccccgt cggcgttagc
     3541 tggcggggga ttttcttttt actcattagc aaaagtataa taaaacgact cagttaagtt
     3601 catagtaaag tttgtataaa cgcaaatcgc ttctcataat catcctcaga tatagataaa
     3661 gcaagataac tatctgacat gatccaccca ttgagttctt ctttatattc aaaattactg
     3721 ttacagtaat gaatgtaacg tgcgatattt gctacgtcat taaaataaag aatggactta
     3781 ttgcatttat catgttctaa agcacaaact aagacaacat catctatttt aatttcaatg
     3841 cctttactta cctcctcctt atacaagtac tcatatatac acatctcttt tttaaagaat
     3901 aatttttgaa tgtgactgct cgtattattt aatacgcttc tacctatata tagtaggttg
     3961 tcaaagtttg aatgcaaatt aagtgtatcc atctcatcat tttttttatt gttattactc
     4021 aactgaatat tccattagca ttattatatc tcaccacaca atcatatatg attgcggata
     4081 tgcaaatata aatactttcc tttgaaaaca atcatatatg acagagatta tgcttgataa
     4141 acaggaaact ttaaatgaga taggtactaa aattagaaaa ttacgggaaa gtaagaatct
     4201 atctatccaa gaattcgcag ataaacttga aatggagtac aacaacgtta ttcgaataga
     4261 gaaagggaga actaatttca ctattggtac tcttgtgaaa atagccaatt ccctagaagt
     4321 aaatttaaag gatatagtat agcaatttga gatgcaagga ttatacaact ccttagaacg
     4381 ctaacctaag gagctgtata tatgaagcat aactattatc aactgaactt catatattga
     4441 ctgaaatgtc tatgcaatta catttaaaac aatttgcgga taagacatca atactcttgc
     4501 aaaccaaaat caatgccaat caaaagtaaa caaaaggttt caactcattt ccttgtttat
     4561 ccaccggata aagagctcct tccttctcta attgagcaga catttcctga atcatctccc
     4621 tgcatttatc cggatgtgcg gaagaaagtt catttctttc ttccggatcg tctttcagat
     4681 tgtaaagcaa ggctttgggt tgtttcggag tctcgggaag ataataataa atcagtttcc
     4741 agtcgcccat gcgataggtg gtgaagtagc tgccgcggtg tgcgtgaggg aagtgcatca
     4801 ggaaagactc gggacgcttc ttgtccacct taccgctcag ttgctttttc agatcgaatc
     4861 cgtctatcac gtagttttgg ggaacttcgc atcctgccac agacagaaca gtcggataga
     4921 tatccatgat tgtgcccaac tgtgtctgca tacttcctac ttcaataggc aagttcttct
     4981 gtactttgct cttcttctca ggctttgccc aagctgcgat gaaaggaaca cgcataccac
     5041 cttcaaactc cgtccccttt ttacctctca gcggagcgga agaaccatag ccacgttcat
     5101 ctcccaatgg agcatcacca ccgttatctc ctaaaaagag aatcagcgta ttttcggcaa
     5161 ttcccagctt ttcgagttgg tccatgatgt cgcctaatga tttatccatg ccttctatca
     5221 atgtagcaaa agctcttgcc tgctcgttct tatccgggtc ggtgtagcgt gacaagaaac
     5281 gtttgtctgc ctggaaaggt gaatgaactg cgtaatgggc catattcaga tagaaaggtc
     5341 gtttttcttc tacggctttg gtgatctccc gattcgcttc tatagtcagc gcttcactca
     5401 ggaaggtatc tgtaccgtga tatttctcaa ggtcaggaac tgctctaatc ttctgtccct
     5461 tgatatgccc gtatccccat tcgccataat agctgccggg atgtccaatg ccggaacctg
     5521 cgatatttac atcaaagccg atattcagcg gattctctcc ttcgcttccc atacagccga
     5581 aatgtgcctt tcctacatga atggttttat atccggcttg ttgcaggact ctcggcatgg
     5641 taggcatatc ttttctgaga cctttccagt tccattgggg cggtccgaaa ggattccgat
     5701 tgttgctctc agcattaatc cagttagtga ctccatgcct ggtcgcattc tgtccggtca
     5761 tgatggaagc tctggaaggg gaactcacgc tctgtgcgta aaaagtagaa aaacaaatac
     5821 cctgtttagc cagtctctcc atattcggag tatgatacca gtcattcagc ggatgacgca
     5881 ccggctgacc actctcatct gcgataaaag gaaccgacgt atccataagt cccatgtcat
     5941 ctacaaggaa gacaataata ttcgggcgtt cctgagccac cccgcaaacg gaagatgcca
     6001 aaccacccaa tacacaaaat tccttaaaag ctcgttttgt tctcattaca tagtatttat
     6061 gatttatatc ctattgtacg tgccataata gatttcaaac tcagactctc ttctgattac
     6121 acaaaagagt attagaaaaa tatcctatta tctttcattc agcataatct atcatgttac
     6181 tattctgctt tgaaacctga ttttaattcg ttgaaataaa aaatttaatt tccgtatcca
     6241 ccttatcatg gctttatttg aagtgatctg actttataat aaagatgtat tagactggtt
     6301 ttaaaggaaa cagctagcaa tatacaacaa atgtactaca cccacaaaga aaaaaatagt
     6361 ttttgacttt ctctctgaaa aattatcaga cgttcttctt gcttgttcta agcatacgtg
     6421 gagaagctcc aaagaacttc ttacagaaat tggagaagtg aggcagagac tcaaaaccgt
     6481 atttatagca tatttcggag atactgtact cagagttatt caagtcatcc aaaatacctt
     6541 ccttacgtcg cgcctgcatc cattcgtata ccggttcgtg gaatacatta ttgaagatac
     6601 gccgcaaggt gctgacggta taacctccca gttgagccag ttcttctacc gtttttactt
     6661 tcttatagtt ctgaaggatg aagtattcaa aagtggtggt gtatttcgag agtggatgca
     6721 ccaaactagc caagtcataa tccgaataat agtagcttag cacaaacgcc agttctttgc
     6781 gctttaaaga cagcagatcc cggcagactt tactttcact caaataggat ttggaaccat
     6841 ccaaaaagta tttcaattca ggaattatct ttaaaggaga atagataagc ggagaaggta
     6901 catccttcat gatatgattg aaacggaagt cacagaatag ttccggctga ataaaacgat
     6961 aatagataca ttcgcactcg gtcatcgcaa gcatctcgta ttttgaacca atagcctgaa
     7021 gaataaattc acctgctttc aacatcgtac ctgcatactc ctgactatta accaagagct
     7081 ctccttttat caaaaaaagg atgaaattat cttcacactt ccgggctggt tgatggtagc
     7141 cccttgtatg ggtagtgtga atgatagcat tgtctacggc tttcggacag ttctgacaat
     7201 cccaagtacc ctgacagatt gatgacatat atttgtgttg gcgtttgatt tgttcctgtt
     7261 tgcaacaaaa atatatgaaa tcttttagat ggcaatagaa aaggagaaga aatttgtaaa
     7321 atcactctca ctgcaagagc agtaacggaa gtgattttac aaattcaaga ctatataaac
     7381 tggtctataa gagactacag tatgagaaat attattgata catcaaacac taggttcagt
     7441 agtttcaggt atttcagtat tccaatcagc gggtgtcgct tcaatcttaa cttcctcacc
     7501 accaacaggc aaagttagtt tatacaaaat tttagttcca aaagcccatg gtgtagtaga
     7561 tttcaaagga atctcttttt tatcattaaa tacataactc tcgcccttct ttgttttata
     7621 tttaattgtt attttagcat tagtaatatc ttgtggtatc aacataagcg cattacctgc
     7681 tacaacagta cttgtcccat caacaaaagc acctaatgta tatgtatatg ttgcatcagt
     7741 atttccaact gcccaagatc ctgtgttagc tcctgcatat gtaaaagtcc catcagactt
     7801 gacaccactt attataacag catcagcttc agtcaattca taagtatagt ctgcatttcc
     7861 ttcaatcact tggatattaa tttgagtcaa tgcgtgtttg aaagttaacg aaaccgccgg
     7921 tgttgcttta tctgtttcct tagttttgtc caactcagat gaaataacta aatccttttg
     7981 agttgaagct gtaagtccta cattataagt aaattgtgga tatcccgcag cagtaccatt
     8041 cgggtcagtg tatgtaactc catctaacgg agaatatgca aagaactgta atttatctgt
     8101 taatggccag taatagggac ctcctgctac cgaccaagca gaagcagcat aggttgcttt
     8161 accagttatc catgctgaag atggaaggac cgtagtaata tccattcccg cagttcctgt
     8221 attataggca taaacttgga aaccagcatt ttgtaaacct tttgtatcta gtacagttgc
     8281 tctagttact gctgtactaa aattaatttc cgccttttgt cctagattat caaaatcttc
     8341 gttctgtgag cagcttgtaa ttgttgcaac tgctgcaatc gccaataata cctttttcat
     8401 aatcgtattt ttttaagttt ataatattgt tatattttgc ttatgcttta tctcaaatta
     8461 cgggcaaagg cacctcctcc tcttctcccc aatcaccaac atcaccgcca ataccaccat
     8521 caccaccaga cgaattttcc ggcttatcaa ccttcacctc atcatcatca agcggtaact
     8581 ctatatcttt agaaggctca tcattgcctc ccccttcacc actctccgaa ttaacaatca
     8641 catccgttat atcaacctct atcttctgta ccgtattatc caccttcaca aatgccagcg
     8701 taaactttat agcaagactt gcccgactca tcgccccttc cggtaaccca aaagcagtaa
     8761 aactacccgt tacttcgccc gaacgccctt gcgcttcaaa gtagatagga gcatcgttca
     8821 tcatcccgca acatctgccc aaacagtaac aacccgccat accttccaca cagccaacga
     8881 ttgaagaaac atattccagc ccttccacct tgatcttgaa agaataggtc tttaccacta
     8941 atttcggttt ccaatccagt agaagctctt cttcactgtt cgctatatgt aaatcatcga
     9001 tctgcactac gtataaggga tcaggtcccc ataccatttt ctccgttccc gctattccca
     9061 gaccattgca atagcctgtg aatgcttcaa tcgtctcata ggcttcctct cctctgatct
     9121 gcaccgtttc agtgtcgtag ttgtaagcca ctactgagta acgccccggc ggcaccttta
     9181 cttttccacc tcttactgaa aggtatgtat caatctttct gccttccgca ctcttcggat
     9241 aaaaaatcac ccgaacccct tccggtaact tatcggtaac accgttccaa tctaacttta
     9301 tatctacccc gcttacggga taatcatcca atagttcgcg acggctacat ccggtcagca
     9361 tcagcagcga ggacagaagc acaagaagta tgtatcttgt atcttgcata acgtccttat
     9421 ctccctcttt ttatcagcca taccagagag actttcgcct tggtaggacc tataaagtta
     9481 taacgtccac tagttgtcca cacgatatcc ccctcgtaag gagtatattt cttatattct
     9541 gttgtcagat acccgatgcc gaagctaaat tcgagcgaca gatggcgagc cagttgccgc
     9601 gcatacccgt aggtcactcc cgcagctccg taataatcgc cccggtaacc gtcgcccttc
     9661 cactggaaat cgtaaattcc accttcagca taaagcccaa caaaatgccc tgtcaaccgg
     9721 ttgcgcttct gacgattgcc caaccagcaa cgtccttcca ctcctcccga aagaagctga
     9781 taacagaaat tgtgtttact gttgagccac cacggacatt tgtattcagc atttaaagac
     9841 caccttttgc ctaccggaat ctctacttcc agatttggcg ccaacgccaa atcgtacaac
     9901 agattattct tcactgcaag caccgtttta ctttcaaccg gcccttctgc ctccgacact
     9961 accacctcat aagccatact ctctttactt tctccctccg gcttatcagg ttgatcgctc
    10021 ggaagcgcct cttcctgctt tgaaacaaac aatccggaga cagaagatac cggttcaaaa
    10081 atattctttt ccatttccgg aactttgcgg acaaccgtaa tctcagcgcg tctcaactta
    10141 ggtaacacgt tgcggacaat atatcggtaa gccattccct gattcaactt ctgcaacagt
    10201 tcttttcgct tcacgatgtt atcccgatga taatctatca acatcaagac ttcttcccgg
    10261 tccggcaagt ctgaatccga cgccaccaac ttacgaagtt cagaccagtc ttctccttca
    10321 gaagtaagtt taatcttttc gacatcaaca tacggataac gttgccttaa gaactctctc
    10381 atcgaattgt ttcttcggac agataatgcg gcattgtaaa ccgaatctcc gtcaggcgat
    10441 acaaaagtga ccacattgag cgcagtgata tatcttgaat ttattctttc ctcaagcaaa
    10501 gaatctaaaa cattaatttc ttgattatta gttttataac aggaatcaac atctgtttct
    10561 tcctgatcga aatatatcac cacccgcctg atagtgtcac tcgcaatcgt gaaaaccgga
    10621 accactgcat acacactttc tgataaagca agaaatgcca tgagaataac gcatgtatag
    10681 attccgtgtt tcataattgt tcgtttatgt gaacaaatat agaagttata atataaacta
    10741 aatcatacta gcagaacaaa aaacaggaca tggaaggttc tgtgaaacga ttggaacgaa
    10801 tttgcaagtt tagaagcaaa taaggaggaa acaatagata caccaaggca ttatataaag
    10861 aaaaaatgca cagaaaatcg agtataaccg attatctgtg catttgcaac ttttcaataa
    10921 gcctttccca cgctgtctgc tacctaaaaa gaaagtacag aagatttata cagtcgggtc
    10981 cggcgcttct tcatcaccct ttcctccgtc tccaccggga ttaggtttta cgctaccgct
    11041 gccattgtta ctacttccgt ccgtatagtc cgtatccaac tccgcacgac gggtaatact
    11101 catatcatcc aacgtggtct tgaatatttt tccaggatag aaaaggatct ttctttggac
    11161 gattgactta gatgatactt ccttctcgtc atccgcactc ttagcgcgaa tggtagggct
    11221 gaagatgccg aactcaccca tctgaacact ctttccgtcg tcaatgtcct ccgccatcat
    11281 atcgacaaga ccgctgacga ccagatccac aactttgcgg tgaactccac aaagacggct
    11341 caccttgcca cacatcttgg aaaaacttac tctgccggaa cgaaccgact ttgctacata
    11401 cttttcgttt ttgtccttgt caaaaccgaa cactcttttt gttactacat actctaaagc
    11461 cataatggtt aaagtttaaa tggttaaaaa aataaaggtt atctgtttgc cattccgttt
    11521 tgtctgaatg actctgcaaa gatataacag ggcgcaaacc gtccagtccc ctttagtccc
    11581 ccttgtgtct cctttcaatg gctttaaagc agtaaatatc ctaaagtaat tcgcttattt
    11641 tcaatcgact atacagatga atattttttt tccaaagtgc gttcattgct gtttctccaa
    11701 atagagtctg tcggtttcca gtctccatat accgacatac ccccgcccgc aatcagtaga
    11761 gaaggagcgc ttcgaaatac aattctttac ctgcttactc agagtctcac tatctcccaa
    11821 tggtcaagta aacatttcca atgtatcttt acctatgacg agatattccc ctctttgatc
    11881 tgttgcctta acctgtatgc agatgccaac atacaaaaag ataataaata gaaaagtgtg
    11941 ctttctcata gctttataat tttagaaaac cgaatataca tatatataat agagcaataa
    12001 tactcatttc ggtatttatc atatgcgaat aaacgaatta ttctgtttgc tcaaatagaa
    12061 ttacgtacaa attagctgca ttatagtata accaacgaaa aagcaacatg atactttgtc
    12121 atacaaaacg gtctatgaga gaaaggtaaa aatagtcatg caaatttacc aatatactaa
    12181 tccaatgaat acgatactgc cttctcccga tttacccaca atgaaaaaca tagacactgt
    12241 atactaaaac cgtatttgag tttctaataa attctttcat cgtttattag aaacggttcc
    12301 caagtttatt aaaaacgccg atacgccttt caaatctctt tttcttgaat ttatgcaaca
    12361 aaaaaggctg caaactccgt aaaagtttgc agccttttgc tcattgccgg gctacttatg
    12421 ccctaatcct cataaggatc tcctagatgt tttgttataa tcttatactg ttttgatgtc
    12481 aaaaaccgat gattgtacgg caagtaacct gtcggtataa gttctttgac caacgggtta
    12541 caacctttaa tccatcggct gagacaatgc accgcatttt tactcgttgt acatccgggg
    12601 aagtacatcg cagccagtgc agcaaaagat aagattcctc tcattcgttt ctaagttttg
    12661 atttgaattt tattgttgtt attacgacta caaatataca acataaaaaa gcctttgtca
    12721 agtcctcaag cccttcgagc gttaataaca aattaaagaa ctggagtact ggcacataag
    12781 caaggattgc atcgtcaatg actaacaagt ttgttactaa caactttgtt agtaacaaac
    12841 ttgttagtta ataaaaaggc tgagattcct caattcagac ccattgtgtg cgataacagt
    12901 gaaaatccgt gaaagaaatc aaaagagacg caaatacaag aatattattt ggaaggaata
    12961 gcaagaagac ttacatttgt catgtgattt ttttcatagt attagattta aggttaacaa
    13021 aggttggagc aaggcgttgc tccttttttt atgccccaac ctttctttat tttacctcag
    13081 agatttatta ctgtcattcc agtactgtca ttgactattt tttcggcttt ccacagatat
    13141 aaaccttgca ttggtaaggc gccaagtcca ccattatgtt attcgcagca ttttccatag
    13201 aacggctgtc aagactatac acctgctcca aagacaggtc ttccaccgtt tttgaattta
    13261 attctatagt acgtggagta tccgcccggt taaaacaagc taccgctttg cgaccgtcag
    13321 ccaacggctt tacccaaata tcataatgat ctgcacggat gctgcgctcc gcctgcttgc
    13381 ccaacacatc ctggttgata gcaatcaggt ccctatccaa cagaacctgc aatgtactgt
    13441 cattcatact tcgcacgtca tttccgcaaa gtaatggaga agccatcata ca
//
