LOCUS       gnlProkkaAEDHAKIC_22    5526 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AEDHAKIC_22.
ACCESSION   gnlProkkaAEDHAKIC_22
VERSION     gnlProkkaAEDHAKIC_22
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 17:00:58
            Original ID  :: gnl|Prokka|AEDHAKIC_22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5526
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..5526
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2:4246]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3..4246
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..5526
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..5526
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(3..1082)
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 2.4e-33.
                     Score: 107.3. Matches aSDomain:
                     nrpspksdomains_ctg22_1_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 79.3; E-value:
                     4.4e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.3e-31, bitscore:
                     98.2, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHD
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIVGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMR"
     aSDomain        complement(204..992)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_1_Aminotran_5.1"
                     /evalue="2.40E-33"
                     /label="ctg22_1_Aminotran_5.1"
                     /locus_tag="ctg22_1"
                     /protein_end="293"
                     /protein_start="30"
                     /score="107.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHDAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIVGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             complement(1079..2215)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_2"
                     /sec_met_domain="TPP_enzyme_N (E-value: 7.5e-23, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.5e-21, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             complement(2227..3528)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_3"
                     /sec_met_domain="CTP_transf_like (E-value: 1.3e-13,
                     bitscore: 39.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 4.6e-123, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.3e-65, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             complement(3548..4246)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_4"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.3e-15, bitscore:
                     44.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDNFLLLESDLVFE
                     RKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             complement(4260..5525)
                     /locus_tag="ctg22_5"
                     /transl_table=11
                     /translation="MRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEILWGFDV
                     KILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLPVPLKVC
                     SIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMDNLHVSE
                     YWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQFFWGIC
                     MLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAAFVLVLMFLIVFVRNN
                     RLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYLIERLIA
                     SLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFVSVLSIF
                     AIYCYFKQQLNSLILIPSEIHD"
ORIGIN
        1 tccctcatca cctcaaagaa cctctcaata tcctccacat caatctctcc caacgcacaa
       61 agccggaatg tattcgttgt ggaaatctta cccgggtaga tcgtaaagcc acgttcatag
      121 cagtaatcat gaaccttatc aaaatcccag aggggatcat caggatacaa tacagaaaca
      181 acaagacccg actgccattc acgtttgatc gcatactgaa gaccaagctc ttgcaaacct
      241 ttatggatgg cttcaaagac cctcttgtga cgggcgaatt tagcctcttc acctactgca
      301 aaatattcat caagagcctg acgggcagcg taaacggttt gaacaggagg agtaaaatgc
      361 atctcacccg tcttctcaaa gtaatcgtat tgtaaataga ggttacaata gtaggaacgt
      421 ttcggataat cccttgaagc acgtatcagg gattcatcac ctacgataaa ggaaagaccc
      481 gtcatggctt gaaggccttt ctgagccgaa gccatacaaa agtcaacatt atccttcccg
      541 atatcaaaag gaatcatacc cagggaagaa gtggtgtcga caacaaaaac ggcatcgtgc
      601 gaatgggcta tttttccgat ctcacggatg gggttcaaga tacccgtacc cgtttcatgg
      661 tgcgtggtat agaccaaagc gatgtccgga ttgtcggaaa gcgtcttttc gattaccgac
      721 aggtcgggaa gttcgtaaac ggaaaacttc aaatcgatat ggggaagacc gtaatattcg
      781 cagacttcca ccgcacgggt gctgtaggca ccgttattga caaccagaac tttcttatcc
      841 gcaggaagaa gagagttcag gcagatatcg atattgatcg tacccgagcc gcaaaacagg
      901 acggccgtat gtttggagag gtctccatgc gcaacgcgga ccaggtcgtc acgtaactgt
      961 ttcatcatac ccgcaaactc tttctcacgc ggacagatat cgggaacaac ctgcgccagc
     1021 tttaccgtat ccgtcgtggt ggcgggaccc ggattcaaaa ggatctttct ttcgatattc
     1081 atgaatgcgt atcttttaaa aatgccataa aatgctcttt attctctacc ggagtagtcg
     1141 tagggcgacc cagatcatca cgtgaatcga tccggacctt aatttcaaga agaaccgggc
     1201 cggacaggcc ggacagcttc tcaagcgcac acgaaagccc ttccttgtcg gaggcagtca
     1261 gtacatgcgc ataaccgcaa cctttcgcta tcgaggcgat atccagacgg aaaccgagcg
     1321 tgggttgacc gccgacagat tcatgggcac cattgttgaa aaggacgtgc ctgtaattct
     1381 tgggagaaag atcgccgata ttgctgacag cacccatgtg catgataaag gcaccgtcac
     1441 cgtcaagaca gtagacacgg cggtcaggct tctcaagggc aatccccagg gcaatggaag
     1501 aactgtgacc catggaaccc acagttagga aatcccttgc gtgcccctgc cctttcgatt
     1561 cacggtactc gaaaagctca cgggagagct tgcccgtggt ggaaaccaca atgtcattgt
     1621 ccccgaggtg gtcgacaacc tgcattagcg cctcctcgcg ggacagagga tagtcattca
     1681 aggcttcctg acgcaattta tattttccaa acgtatcttt acggatgaca atcgcatggg
     1741 gaatcgaccg gctcttcgcc gagacaaccg cgtcatggat ctgcgccagg gcctcgtctt
     1801 catccgtatc cagaattata aaaggaattt tcatggcttt cagaagatca agggtaacct
     1861 cgccctgctt cttatgctgg ggttcgtctt ttgtgccggg ctcaccgcgc cagccgacca
     1921 gcaaaagaag aggaaggctg tacactttct cgtccgcaag ggacaagagg ggattcaccg
     1981 tatttcccag accggagttc tgcatataaa ccaaaggaac gttgccagaa gccatataat
     2041 aaccgcaggc aatgcccacc gcggaacctt cattggcggc gatgatatgc ttaccacgcg
     2101 gagcatgatc cgtgatatag gcgcaaatat tcttcaaaag ggaatcggga acacccgtaa
     2161 agaagtcaac accgtgatga aggaacgtat cgtatatctt ttctacactt accataaccg
     2221 tctgatttat ttagtgcccg gaatcaattc cagaatttcc ttgataggca tacaaagcgg
     2281 acggacctcc tcggcgcgct cgttttcaag gatggtcctg gccacgttca tcatggccgg
     2341 gtaagcggca cggagaaggt ggttggcgta aatgactacg ttggcacccc attcgtgaag
     2401 ttcggattcg tgcacatggt cataagtcgt cggaacaacg acaatgggaa catgggcgta
     2461 ttctttgcgg aaagtccggc agaactcacg gatatcctca cccgacttat ccttgctgtg
     2521 gatcatgatg ccgtccgcac ccgcctgtac ataggcataa gcacgttcga gggcgtcact
     2581 catgggtttg ccggcaataa ggctttcgat acgcgcaatg atcataaagt caccggtgac
     2641 ctgggcattc ttccctgctc tgatcttatc gcagaaaccc tcgatactat cctgagtctg
     2701 gatagcgtca gtaccaaaaa gggaattctt cttcagaccg actttatctt caatgattac
     2761 cgcagaaatg ccgtgacgtt ccagagtgcg cacagtaaag acaaagtgtt cgatcttgcc
     2821 acccgtgtct ccatcaaaaa taataggctt ggtggtacat tcaaggatat tgttcaggtc
     2881 ctgtaaacgg gtggtaaggt cgaccgcttc aatatccggt ttacccttac tcgtagagtc
     2941 ggtcaggctg ctggaccaca tgccgtcaaa gacctcgcgc ttatcaccct tctggacttc
     3001 aagattctca ataatcagac cgcaaagacc gtcgtgagcc tccaggatac ggaccacagg
     3061 cttggcctgg atcaggcggc ggagggactt aagacgtacg tcaggggtag tcccgatcgc
     3121 cttgatatcc ttgtcgagcg aggaggagtt gatgccccgg gtataaggga tctcgattac
     3181 cttgcccccc tgggcgttca tcacctcaaa aacctgttcg cgcacctcgc gcaacgggcc
     3241 cgttttccag tcgtcaccgt ggatgatata gtcaggcttg agtttttcca gattcggaac
     3301 atagctccaa tcctcctggg gaacaacttc gcaaacccct ttgatattct caacaacctc
     3361 cttacgctga tcataggtaa ggtaagggag gcgtttgtgt tcggcgatgg ccttgtccgt
     3421 cagcagaccg acgatgacat caccgtattt agtagcttca tgaataatat ggatcagccc
     3481 cggatgcatg atatccgcgg tcataccgac atagattttc ttgttcatat atggaaaaga
     3541 tttgttttta acaatagcgg atgatgtgct cctcggcata cgaaaggtcg gcttcatcat
     3601 cgatttcata ccatttaaga ccctccaccc tgagcacacg gacaggggaa acggaacggg
     3661 acatgcggag cagttcgtac tcgtaaccca gtttaggctg ggactccagg atggtcgcat
     3721 aatcggcgca catccggcgg tagaaagtat tggaaagttt atggataccg accagctcgc
     3781 cttttgcctc aagggcgttc ttgtctaccg aacaggaagt aaggatgtga ttgcggtcat
     3841 attccacata atactgatcc tggaacttgg tcagagaaga gacaagcatc acatccggga
     3901 attcgtcatc cagtagcgag aggatggcct tgcgttcaaa aacaaggtcc gattcaagca
     3961 gcaggaaatt gtcatcgcct atcacgtcac gcgtattgta cagagtgtac atactgttag
     4021 tatcggcata acggggactg aaacaggtct ctatctgggg gaaatccgcc tgaagggctt
     4081 cataagcctc ttttttataa cccgtaccga ggatgatacg ttcgataccg caggaaagaa
     4141 gggtttcgat agagcggata atcataggtt ttccaccaac ctccacaaaa cctttgggca
     4201 caagctcggt ataatgcccg aagcgggtac caagaccggc agccatgatc attgctgttt
     4261 taatcatgaa tttcagaggg aattaatata agtgaattca attgttgctt gaaataacag
     4321 taaatcgcaa aaatcgacag gacagaaaca aatcctgaaa aaagggcagt acgcattagc
     4381 atgacagtcc aggaaatgtc agcagaaacg aagttcttga ccataaacac acccgtagtg
     4441 cccagatagc cgaaagaatc ggccaaataa ataataaaaa cagccgtact aaccacccta
     4501 agggaagcaa tcaggcgttc tatcaggtaa gtgaaaggaa tataccccat atacagacca
     4561 agaccggaaa gaatcatcca ccaaatagga gaaagaaaac cgtacacata aagcaatgtg
     4621 gaaaaaacca ttaaggaacc gcctgtgacg gcaatgcaat aaatgatatt aagagccaaa
     4681 cggttattac ggacaaacac aatcaggaac atcagtacaa ggacaaaagc ggcaatggga
     4741 acctctgtct gagtaaagat cattgcaccc tcaatatgga gctccttcca aatatcggca
     4801 gcgaaagagt cacgaagctc acggaacacg gtcagggcac cgtaaaaaac aaccagcatg
     4861 cagattcccc agaagaattg cctcaaaaac ttacgcctgt ctttaccatc catcggagca
     4921 cgtttggtac gctgtatgat atcttgctca ttgggagccg gaatctgatt gagaagccag
     4981 ctgcaaagca acataacagg gtataccaac aaaccggtgg taaaaggcat ccaatattcc
     5041 gacacatgca aattatccat cacgaattgt cccaaggttt tcaccaaacc ggaagagact
     5101 atcaaagcaa cgctcagccc gacattcaat atttcactga tacgacgccc ttcgatatag
     5161 ctaaaaatga caccccagat catacccagg ggaagaccgc tcagaaaaat agaacacacc
     5221 ttcaaaggaa ctggaagaag tgcaaaaccc aacaaagcaa cttcggaaaa agtaagcagc
     5281 cctattatat aatagatgcg gtgacccgct ttcatcgaag gcaaaatacg aacaccgatg
     5341 aacttggaaa gggcgtagcc gataatctca gaaaggacat acaggatttt gacatcgaat
     5401 ccccaaagga tctcaccttc ataaatggct gcggtaaatg gcttacggta ggcataggca
     5461 caagtataaa ccagaaaaat caaaacgctg gcatagagag ccaaaacgta aaggggagaa
     5521 cgggaa
//
