LOCUS       gnlProkkaJJGLIHIO_99   15274 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JJGLIHIO_99.
ACCESSION   gnlProkkaJJGLIHIO_99
VERSION     gnlProkkaJJGLIHIO_99
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 17:10:19
            Original ID  :: gnl|Prokka|JJGLIHIO_99
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15274
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15274
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6545:6893]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6546..6893
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15274
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15274
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(2..1543)
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 56.1; E-value: 3.9e-17)"
                     /gene_kind="transport"
                     /locus_tag="ctg99_1"
                     /transl_table=11
                     /translation="MSSLKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASSLNNTD
                     LAHWLMYGGLGFMILGNGCFKPTVSSLVGQLYEPGDKRLDAAYTIFYMGVNVGSFAAPL
                     ICGFLGDTGNPQDFKWGFLASGIMTLFTVVLFETQKNKYLFSPSGEPIGIVPDARREKK
                     EDKAEHISHPKMDKRTKVRNIIIITALTVALIAFFSYAFSDDWISVGIFTACIVFPVLI
                     LLDGSLTKVERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTDRSIFGWEMPASW
                     FQSFNPLFVVILAYIMPGIWSFLNKRNMEPASPTKQAIGLLLLSLGYLFICFGVKDAIP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEDGKVKSILGYQIATMYDFFMLFVIMSGVASLILFLLSKKLQKMMHGVE"
     CDS             complement(1736..1960)
                     /locus_tag="ctg99_2"
                     /transl_table=11
                     /translation="MMEKKRIGSNAGKVWRILNEKGEQSMFTLCHELGLTFEDVAIAIG
                     WLARENKILLRKKEGMLYASIENVEFTFG"
     CDS             2233..3066
                     /locus_tag="ctg99_3"
                     /transl_table=11
                     /translation="MTTKKLTGILSLFLCIICLVSCNDNDDNFSPITLEYEDPQIKFDN
                     ESRSYTLTPFSKETTPLFIKGGDGTYKVTNENEKVVQVNYHNGSLTLKAKEIGRASIKI
                     EDSSNNMYILSVVVKYRTLTHKAFTAKVIVKGDELTSEEHTELMNKVGNSYPINKYVFT
                     FMNAEDSKGTVDLYYSDNNMKTGNFEKEHIVLDEENAIPIKGEYKLSEYYRITIKEDNG
                     KVIDTFYITKNFLPLLNTRMNAHPLIQYCFVRDLTAQYKQDYLALENAYLIQIAE"
     CDS             3598..5109
                     /locus_tag="ctg99_4"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITNRWNP
                     ETPVTIFAGPGNNGGDALAIARMMAEKGYKIEVYLFNTKGELSPDCQTNKELVEMMEEV
                     TFHEISTQFVPPTLTPEHLVIDGLFGSGLNKPLSGGFAAVVKYINASPAMVVSIDIPSG
                     LMGEENTFNVKSNIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEEGIEETET
                     NYEMLEIEEIRSLIKPRQQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPLCNNDILQTSAPEAMVETDVSETCFAVPTDTDDYQAVGIGPGLGRSEETEAALIEQ
                     LEHCQTPTVLDADALNILANHRHTLTHLPKGSILTPHPKELERLVGKCQDSYERLMKAC
                     ELAHTAKVHIILKGAYSAIITPEGKCYFNQTGNPGMATGGSGDVLTGVILALLAQGYPA
                     EDAAKIGTYIHGLAGDIAQKKQGMIGLIASDIVTCLPTAWRLVSE"
     CDS             5183..6247
                     /locus_tag="ctg99_5"
                     /transl_table=11
                     /translation="MKKFIIATGLLVATSAYAQTEVLTGVTRGKDYGVVYALPKTQIEI
                     EIKANKVNYKPGEFSKYADRYLRLTNVSAEPEEYWELNSVKVKPVGVPNSEATYFVKLK
                     DKTVAPLMELTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMFSGVRNK
                     EEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIPQEDGKK
                     KKEMEGIAYNVPGQAMVTLSDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     VTGGLLKVDREESK"
     CDS             6269..6556
                     /locus_tag="ctg99_6"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLKDGKEASRLRRERRNDKLGRLRRNNDPYLLP
                     DTTPEEMERIIKDSEKKKEKDNSYFVWGTLIIMGVLIGCAVLLWAIIFNG"
     CDS             complement(6546..6893)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg99_7"
                     /sec_met_domain="PF05402 (E-value: 1.5e-17, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 5.7e-10, bitscore:
                     29.0, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEQEGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQYEAGYESRVSTYLSQLQ
                     KDGFIKWIIIH"
     CDS             complement(6938..8326)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 90.5; E-value: 1.4e-27)"
                     /gene_kind="transport"
                     /locus_tag="ctg99_8"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKVENKKKGYGLEEA
                     NIQK"
     CDS             complement(8617..9012)
                     /locus_tag="ctg99_9"
                     /transl_table=11
                     /translation="MYLLFIILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSVATAYVVPSSSAAKDVLLEQAQKEQQTNPYNMPTGTAAP
                     QTDATAPAESAPATEAPATETPAPVAE"
     CDS             complement(9035..9796)
                     /locus_tag="ctg99_10"
                     /transl_table=11
                     /translation="MTSVNLQQWIQHPETLNRDTLYELRNQLARYPYFQSLRLLYLKNL
                     YILHDINFGAELRKAVLYIADRRKLFHLIEGERFAVESQKKGLPLSEVLKDEPTVDRTL
                     ALIDAFLSTAPEEVTSQTSFDYSMDYTAYLLEETPVADEPAEAMPKLKGHELIDNFIEK
                     SETDPVVYLKPLREEEKAKAASSAETNETGRTDETTETNTIEEEDDSCFTETLAKIYVK
                     QQRYSKALEIIKKLSLKYPKKNAXXXXEIDY"
     CDS             complement(9801..10328)
                     /locus_tag="ctg99_11"
                     /transl_table=11
                     /translation="MNWIKKIARPLILVVLPAVIIACSVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(10315..11556)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 388.8; E-value:
                     6.1e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg99_12"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFAADFAEKYRMPAIQLTEDAKKI
                     LLAYPWPGNVRQLKNITEQISIIETNREITAAILQTYLPAQNTQRLPALFGTRESKSFE
                     SEREILYSVLFDMRQEVAELKKMVHNMMAERAGQVGQMGQVVATPVVTTTHQPSVPAII
                     HAVQQPSVCPKEDDDDIQDTEEYVEETLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(11680..12774)
                     /locus_tag="ctg99_13"
                     /transl_table=11
                     /translation="MEENKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDVQANFSIVNTASEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGNKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEIIIPAMKEMEEKGIICYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLASEDSFRQAIYVAIDVFRNRQREKAARVN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(12779..13816)
                     /locus_tag="ctg99_14"
                     /transl_table=11
                     /translation="MKKYFFYLSMALVAFVVASCGLKGNHTSSGRPYELLVVVDAGVWD
                     RAAGRALHDVLDSDMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIVIVDIKDIYTKGTF
                     KYAKDVYASPQMILTIQAPNEEVFEKFVEENKQTIIDFFTRAEMNRQITLLEEKHNNFI
                     SNKVDSLFGCDIWIPSELNNSKTGEDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGYKEGVYMSTDSLLTDVRPINVHNDYTMEARGLWRMKGDFMGGPFV
                     SHTRLDQKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPQEGQQSQIPLGVTREA
                     EPTNK"
     CDS             complement(13834..14871)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg99_15"
                     /sec_met_domain="PF04055 (E-value: 1.3e-17, bitscore: 54.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMSKYPLLGMTLIELQSLVKRLGMPGFAAKQIASWLYDKKVTSID
                     EMTNLSLKYRELLKQNYEVGAEAPVEEMRSVDGTVKYLYPVGENHFVESVYIPDDERAT
                     LCISSQVGCKMNCKFCMTGKQGYSANLTAHQIINQIHSLPERDKLTNVVMMGMGEPLDN
                     LEEVLKALDILTGSYGYAWSPKRITVSTVGLRKGLRRFIEESDCHLAISLHSPVTAQRA
                     ELMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCR
                     INLIRFHSIPGVALEGADMDTMTRFRDYLTTHGLFTTIRASRGEDIFAACGMLSTAKQE
                     ENNKS"
     CDS             complement(15010..15273)
                     /locus_tag="ctg99_16"
                     /transl_table=11
                     /translation="MVSELRSSEPLVGAYASVAEMNKLSAPIKGNAGVFVLQMYGKDKL
                     SDTFNAKVEEATLANMHARFASRLMNDLYLKGKVKDTRYLFF"
ORIGIN
        1 attctacccc gtgcatcatc ttctgtaatt tcttcgagag aaggaacaga atcagtgagg
       61 caacaccgga cataatgacg aacagcatga agaagtcgta catggtagcg atctgataac
      121 caaggattga tttcactttt ccgtcttcgg gatagaggcc gctcagcata cctgcaaatt
      181 tatttgcggt ggcggtagaa agataccaga tccccatcat caaggaggcg aaacgtaacg
      241 gactcaactt attaaccata gaaagcccga taggtgacag agcgatttct cccattgtat
      301 gaataaagta aagccctgtc agccagatca tgctcacctt tactcccgga atagcatctt
      361 tcactccaaa acagatgaag agataaccaa gagaaagcag taacagaccg attgcctgtt
      421 tggtagggga agccggttcc atgtttcgct tattcagaaa gctccatata ccgggcataa
      481 tataggcaag gatcactaca aaaagcggat tgaatgactg gaaccacgaa gccggcatct
      541 cccagccgaa aatgctgcgg tcagtctgtt cggaagcgaa taatgtcaga gaagctcctg
      601 cctgctcgta agctgcccag aagaaaatga cgaagaaagc tacgatatag attacgaaaa
      661 tacggctacg ttctactttg gtcaatgaac catccagcag aatgagcact ggaaagacaa
      721 tacaagccgt aaagataccc acactaatcc agtcatcgct aaaggcatag ctaaaaaaag
      781 ctattaaggc aactgtaaga gcagtaatga tgatgatatt acgtactttg gtacgtttgt
      841 ccatcttcgg atgtgaaata tgttcggctt tatcctcctt tttttcacgt ctggcgtcgg
      901 ggacgatacc aatcggttca ccggaaggag agaaaaggta tttattcttc tgagtttcaa
      961 agaggacaac agtgaacagc gtcatgattc cggatgcgag gaatccccat ttaaagtcct
     1021 gcggattccc tgtgtctccc aagaaaccgc aaatcaaagg agcagcaaaa gaacctacat
     1081 taacacccat atagaaaatg gtgtatgcag catccaaccg tttgtccccg ggttcatata
     1141 attgcccgac gagcgaagaa acggtaggct taaagcaacc gttacctaaa atcatgaatc
     1201 cgagcccgcc atacatcagc cagtgggcaa ggtctgtatt gttcagtgaa gaggcactca
     1261 taaacatcag gaactgaccg actgccatca tcaccgctcc ccaaaatacc gaacgacgga
     1321 tgccccaata tttatcggca atgtatccgc cgatcaacgg agtcagatag accagtccgg
     1381 tgtagctacc gtagatagag gccgccgctt ctttatcaaa aagcaatgcc tgcgtcagaa
     1441 agaggataaa gatagcacgc ataccgtagt aactgaaacg ttctgccgtg ctcgttgcga
     1501 aaattaggta aaggcctttc gggtgccctt tcaatgaact catgaattat gtgtttagta
     1561 gtttatgggg tgcaaaggta ctaaaaagta gattaaatgc ctcaaaaaag aagattctta
     1621 tggaatagaa aaatacagga tggcgtgcaa aaagtctcag ttacccacct tattatgttt
     1681 tcaacagtgt aaataatcaa gtggatattc tccttaaatg tgggtcagtc cccatttatc
     1741 caaaggtaaa ttcaacattc tcaatactgg catagagcat tccttctttt tttctaagca
     1801 ggattttgtt ttcccttgcc agccaaccga tagcaatcgc tacatcctcg aacgtcaaac
     1861 ctaactcatg gcacaaagtg aacatagact gttcgccctt ttcatttaag atgcgccata
     1921 ctttcccggc atttgagcca attcttttct tttccatcat gcaaacttta gaagattaaa
     1981 caatttatat ttataatcta aacattgtga gcacaggaga ataacgtaaa gcacattact
     2041 gcactacaaa gatatcattt ttttcgaaaa aagcaaataa tcaaagcatt agctgctatt
     2101 attagttaca ttctaatcat ttatgccgat ctctgctaaa aaatagcaca aataaagaaa
     2161 cagttcaatt ctttttcata agtttgcaga cgagaactaa actaatatcg cacatttaaa
     2221 actttaatta gcatgactac caaaaaacta acaggaatac tttcgttatt cctttgtatt
     2281 atttgcctcg tgagctgtaa tgacaatgat gacaactttt ctccaatcac tctggaatat
     2341 gaagatcctc aaattaagtt cgacaacgag agccgttctt acacactgac tccgttcagc
     2401 aaagaaacga caccactctt catcaagggt ggagacggaa cttacaaagt gaccaatgag
     2461 aatgagaaag tggtacaagt aaactaccac aacggaagtt taacattgaa ggcaaaggaa
     2521 ataggacgcg catccatcaa gatagaagac agttcgaata atatgtatat actgtctgtc
     2581 gttgtaaaat atcgtactct tactcataag gcgtttacag caaaagtcat tgtgaaggga
     2641 gacgagctta catctgaaga acacactgag ttaatgaaca aagtgggcaa ttcatatccg
     2701 attaataaat atgtatttac ttttatgaat gcggaagaca gcaaaggaac agtagatttg
     2761 tattattcag ataataacat gaaaacaggc aactttgaaa aagaacatat agtgctggat
     2821 gaagaaaatg ccattcccat caaaggtgaa tacaaattga gtgagtatta ccgtataaca
     2881 atcaaagaag ataatggcaa agttattgat actttctata ttaccaagaa ctttctacca
     2941 ctcctcaata caagaatgaa tgctcatccg ttaattcagt actgttttgt cagagattta
     3001 accgcacagt acaaacaaga ttaccttgca ctggaaaatg catatctgat tcaaatagca
     3061 gaatgagagc tacactgatt ttcttcttta gcagagtgaa tagagtattt attatatgag
     3121 caaactcccc attagattta gcaaaaaaca ataagctatt agctaatcaa gaatatgccc
     3181 atagcatatt tatcacaatc acctcttcca cccttttcct gaacctttga tgaataaggc
     3241 gattgcgggt gaaagaggtg aaccagagga atatacagta gtagaaacac gcatgggaag
     3301 gttaacaaac agccatgaat gttctccgga gagagtaaaa gtaaatgaga taacaatgct
     3361 tgttatactg cgttacaagc attgaaagcc atcataacaa gcattgatat ctaccataac
     3421 aatcattaat atctgacttc tcaactatta ataactgaca catcaactat taatacctga
     3481 caactcaagt attaatacct gaagttcctt cccaaaaagc cgaaaaccaa ccggaataaa
     3541 ggattaattc agagtttttg tgtaagtttg tgcgtcgaaa actaaaagaa tatcgcaatg
     3601 aaaatatttc caagcagcag cattaagaag ttagatgcct ataccattga acatgaaccg
     3661 attgcatcca tagatttaat ggaacgtgcc gcacaggcgc tgactaaagc catcaccaac
     3721 agatggaatc cggaaacacc tgtcaccatc tttgccggac cgggcaataa tggcggagac
     3781 gccctcgcca tcgcccgcat gatggcggaa aaaggataca agatcgaagt atatctcttc
     3841 aacacgaaag gcgaactttc gcccgactgt cagaccaaca aagaactggt agagatgatg
     3901 gaagaagtaa ctttccatga aatcagcacc cagttcgtac ctcccacact gacaccggaa
     3961 catctcgtga tcgacggatt attcggttcc ggactcaaca aaccattgag cggaggattc
     4021 gctgccgttg tgaaatatat caatgcctct cccgccatgg tagtctccat cgacatccct
     4081 tccggactga tgggagaaga aaatacattc aatgtaaaaa gcaatattat ccgtgcggac
     4141 gtcactttca gcctgcaact tcctaaactg gccttcctct ttgccgaaaa tacagaattt
     4201 gttggcgaat gggagttatt ggacatccag ctgagcgaag aaggaatcga agagactgaa
     4261 acaaactacg aaatgctgga aatcgaagaa atccgttcgc taatcaaacc acgccaacaa
     4321 ttcgcccata aaggaaactt cggacatgcc ctgctgatag ccggctcaaa aggaatggca
     4381 ggtgcatcgg tactggccgc ccgtgcctgt ctgcgatcgg gagtaggtct gctgaccgta
     4441 cacgcgccgt tatgcaacaa cgatattttg caaacgtccg cccccgaagc catggtagaa
     4501 acggatgtca gcgaaacatg ctttgccgta cctaccgata cggacgatta ccaagctgtc
     4561 ggcatcggtc cgggactcgg tcgcagcgag gaaacggaag ccgccctgat agaacaactg
     4621 gaacattgtc agactccgac ggtactggat gccgacgcac tcaatattct ggccaatcac
     4681 cggcatacgc tcacccatct gccgaaaggt tccatcctca cccctcaccc gaaagagctg
     4741 gaacgcctgg tcggcaaatg tcaggactca tacgaacgac tgatgaaagc ctgcgaactg
     4801 gcgcacactg ccaaagtaca tatcattctg aagggagctt attccgccat tatcaccccc
     4861 gaaggcaaat gttacttcaa ccagaccggt aatcccggta tggcaacagg aggcagcgga
     4921 gatgtactga caggagtaat ccttgcactc cttgcgcaag gctatcccgc cgaagacgcc
     4981 gcaaagatcg gtacttacat tcacggattg gccggagaca tcgcccagaa aaaacagggc
     5041 atgatcggat taatcgcaag tgatatcgtc acctgtctgc cgacggcatg gcgacttgta
     5101 agcgaataaa agttaagaac ttacggttta ttcaataact tcattaactt tgtttttcaa
     5161 aatcagctaa aaagaaccga atatgaaaaa gtttatcata gcaacaggac tactagtggc
     5221 aacttccgcc tatgcgcaga ccgaagtgct gacaggagtg acgcgaggaa aagactacgg
     5281 agtagtgtac gccctcccca aaacccagat agaaatagaa ataaaagcaa acaaagtcaa
     5341 ctataagccg ggtgaattca gcaaatacgc cgaccgctac ctgagactga ccaacgtctc
     5401 tgccgaaccc gaagaatact gggaactgaa cagtgtcaaa gtgaaacctg taggtgtacc
     5461 aaacagcgaa gctacttatt tcgtcaaact gaaagacaaa accgtagctc ctcttatgga
     5521 actgactgaa gagggtctta tcaaatcaat caacgtcccc tacagcagca acaatgcaaa
     5581 gaatgcagca aacaatgccg ttgctcccca acgaaaagcc aatccccgcg actttctcac
     5641 agaagaaatt ctgatggcaa gttcaaccgc caagatggcc gaattggtag caaaggaaat
     5701 ctataatatc cgcgaaagta aaaacgcatt attgcgcgga caagcagata atatgccttc
     5761 ggacggcgca caactcaaaa tcatgctcga caacctgaat cttcaggaag aagccatgac
     5821 cgagatgttt tcgggagtcc gcaataaaga agaaaagaca tttactgtcc gcctcactcc
     5881 ggataaggaa ttcgacaatg aggtagcttt ccgcttttca aagaagctgg gtatagttgc
     5941 caacaacgat ttggcaggca ctccattcta catcagtctg aaagacctga aaacggtgaa
     6001 gattccgcaa gaggacggaa aaaagaagaa agagatggaa ggcattgctt ataacgtacc
     6061 gggacaggca atggtgacgc tgtcggacgg caaaaagaaa ttgtatgaag gagaaatacc
     6121 tgttactcag ttcggtatca tagaatacct tgctccggta ttattcaaca agaactcgac
     6181 catcaaagtt tactttgatc cggtgaccgg tggactactg aaagtagata gagaagaaag
     6241 caaataaaac ctctaaaaaa acaaaacgat gggtggcgaa ggacatatgc tcgacatgat
     6301 acgtcggctg aaagacggca aagaagcctc ccgcttacgc cgtgaacgga gaaatgacaa
     6361 gttagggcga cttagaagaa acaacgaccc ttatcttctg ccggatacga ctccggaaga
     6421 gatggaacgc atcatcaagg attcggaaaa gaaaaaagaa aaagataaca gctatttcgt
     6481 atggggaacg cttatcatta tgggcgtact gataggatgt gctgtcctcc tgtgggcaat
     6541 catttttaat ggataattat ccatttaata aatccgtctt tctgtaattg ggaaagatag
     6601 gtagatacac gagactcgta gcctgcttca tattgaaagt ggtctgcgag tttttctata
     6661 atctcacgaa ccgtccgctg cccgtctatc aggttccata cggccgtacc gtgttcttcc
     6721 agacgcacat gaatatcttt ggacattcct ttcggcaata aataacgact catccacgaa
     6781 cgtttaaaac gagggaagga gagcacaata gtctcccctt cctgttcagc tttaatatgt
     6841 tcgttacgac aagggatcac ctccaggagg tttattttct ctttcgtagc catatctttt
     6901 ctcttttata tcttttcaga tagaatatat actgtgatta tttctgaata tttgcttctt
     6961 ccagtccgta gcctttcttc ttgttttcca ctttcagcat caaggcaaca atcagggcaa
     7021 gtacaccgaa catagcaaaa atagccatcg gcaaggtata atcataagtc tgtgcaccat
     7081 ctacaaccgg acctttgcaa taagagttca acacccatcc gatcagcaaa ggcacgccca
     7141 tcaatcccca gttctgtacc caaaagatca gcgcataagc cgttcccaac tgtttctccg
     7201 gaataatctt cggaaccgaa ggccacattg ccgaaggaac caatgagaaa gcaaatccca
     7261 gaataatcat gatcaccgtt gcaaaccacc atatattcag aataggaaga gcgaacatcg
     7321 tgtgtacgaa aatcagcatc accgacccga tcaccatcag cgtggctccc ttaccgatac
     7381 ggtcatacaa tgaaccgaac aacggtgtca ggatgatcgc gccaatcggc agcaatccgg
     7441 gaatcgttcc cgcaagtttc ggatcaacat tgtacttctg taccatcaaa tcggccgcat
     7501 acttgatgaa ggggaataca gccgaataga acaatacgca cagtaatgcg atcagccaga
     7561 atcctttgtt ggtaatgata tagacaatgt ctttcatgcg gaaaggttct tccggttcca
     7621 gtccttccgc atccagtgaa gcatccagtt tcttatcgta gaaagtatag atgaagaatg
     7681 cgatggtacc tacgcacaac atgacgagac agaacagaat aggagcggga atattggtat
     7741 ggaatacgcc gctctcatcc gtagacccga agaagtctgc caaaggaacg gtaagcacca
     7801 tggccaaagt tgttccaata cgcgcggtcg ccatttccag tcccatagcg agagccatct
     7861 ctttgccttt aaaccacttc acgataatct tcgaaacggt gatacccgca atttcgactc
     7921 ctacaccgaa aatagcatag cccaatgcag ccaatgtgac ttgcatcttg aatccgaaaa
     7981 gcatcgcacc ttccgggaaa gtagtagtaa tagcataata tttcaatcca caaccgaaca
     8041 ccatcaataa acaggcaccc attccggtga agcgtactcc catcttatcc agaatgatac
     8101 caccaaagat gagcatcagc aggaatacat taaaccagcc ataagcactg gtgaaaaaac
     8161 cgtaatctaa actgtcccag agaagttctt tttcaagcat gggtttcaga ggagacataa
     8221 cgtctgtgag gaagtagccg cacaacatgg taaaagcgac taatgctaga acactccaac
     8281 gcagcactgc ggagtcattc agcttttgtt tcaattgttc tgtcattgta atatttaaaa
     8341 ggagttaata atctcgtaac gggcaacaaa gttaactaat tatcatttgt tttactaaaa
     8401 aaggagaaca ttttataaga aaaaggacat ctgaccggat attcctgtat gaagaagagc
     8461 agaccgggcc caataataaa gacaggcgcg aactacacgt attacacgat tctattagaa
     8521 tctcttgtaa ttcgcgtaat tcgcgcctat aatgaagaga acgggtcaaa aagcccgttc
     8581 actcaataag tttaaaccga atatcctgtc actgaattat tctgctacag gagcaggagt
     8641 ttcagtagcc ggagcttccg ttgctggtgc agactctgca ggagcagtag catctgtctg
     8701 aggagcagca gtaccggtag gcatattata cgggttggtt tgttgttctt tctgtgcttg
     8761 ttccaacaat acatctttag ctgcagaaga agaaggaaca acgtaagcag tagcaacgct
     8821 catcacaacc atgaagatag ccagacccca agttgctttt tccagaaaat ctgtagtctt
     8881 gcgcacgccc atgatagcgt ttgatgaaga aaaaccagaa gcaagtccgc ctccttttga
     8941 attctgaatc agcacgatga agcacatcag caaggctgca atcaccatta agataatgaa
     9001 taataagtac atttttagtt attttgaatt agcgttaata atcaatttct cnnnnnnnnn
     9061 nagcattttt ttttggatat ttcaagctta attttttaat tatttcaaga gctttcgaat
     9121 atcgttgctg ttttacgtag attttggcca aagtttctgt gaaacagctg tcatcttcct
     9181 cttctatggt gttggtttca gttgtttcgt ctgttctgcc cgtttcgttt gtttcagcgg
     9241 aagaagctgc ctttgctttc tcttcttccc tcaaaggttt caggtatacg actggatcag
     9301 tctcgctttt ttcgataaag ttgtcaatca gctcgtgtcc tttcagcttg ggcattgcct
     9361 ctgccggctc gtcggcgaca ggtgtctctt cgagaaggta tgccgtatag tccatggagt
     9421 aatcaaagct tgtctgactg gttacttctt cgggagccgt cgaaaggaaa gcatcgatca
     9481 gagccagtgt ccggtcgacg gtaggctcat ctttcaatac ttcagagaga ggcagccctt
     9541 tcttctggga ttcgacagcg aagcgttcgc cttcgatcag atgaaacagt ttccgtcggt
     9601 cggcaatata cagaacggct ttccgcagtt ccgcaccgaa attaatgtcg tggagaatat
     9661 acaggttctt gagatacaac aaccggagcg actgaaaata cggatacctc gcgagctggt
     9721 tgcgcagttc gtacaaagta tccctattca gcgtctcggg atgctgaatc cattgttgca
     9781 agttaacaga agtcattaaa ttaccagttt gctacagttg cattaaatat ttggtcggtt
     9841 atctctttac tcatttccgc tattaatcca tcctgtacgg ctgtcagtag ctggctggaa
     9901 tcataggtac ggaaagctga gaattgttgt tcgaagtctt cggcgtgatt tgtgttgttg
     9961 acaaagcgta cattgaccgt gatggtcagc ttcgtttccg aagagtaacc atcggcagac
    10021 actgcctggt tatactggtt gtagcccgta atttcaccgt caatctgcag atccgcattc
    10081 tggttcggtt tcagcagttg cagacgggtc tgtctgatga agatatcttt caggtcttca
    10141 ttgaacttgg tagccagcgg agcatacaca tactccgact taatcgggaa atcagcaatc
    10201 gaaatagtct tcaccttatc gtaattgata gaggagccat taaacttata ggacacacta
    10261 caggcgatga tgactgccgg taaaacaacc aatatcagcg gtcgtgctat tttcttaatc
    10321 caattcatat tcttttattt ttctgtaaag ggtacgctcg gagatattca gatccttcgc
    10381 cgcacttttc cgcttaccat gatgcctctc aagcgcttta cgtatcattt ctttttccac
    10441 ttcatcgagc gaaagggttt cttccacata ctcttccgtg tcctgaatat cgtcatcgtc
    10501 ttctttggga caaacagacg gttgctgcac agcatggata atggccggca cggaaggttg
    10561 gtgcgtcgtt gtcactaccg gagtagctac tacctgtccc atctgtccga cttgtcccgc
    10621 acgttcagcc atcatattgt gcaccatctt cttcagttcc gccacttcct gacgcatatc
    10681 gaacaagaca gaatatagta tttcgcgttc gctctcaaag ctcttgctct cgcgtgtgcc
    10741 gaacagtgcc ggaaggcgtt gggtattctg tgccggaaga taggtctgca gaatcgcagc
    10801 cgttatctca cggtttgttt ctataatcga aatctgctct gtgatgttct tcaactgccg
    10861 gacgtttccc ggccacggat aagcaagcaa tatcttcttg gcatcttccg tcagctggat
    10921 agccggcatc cggtactttt cggcaaagtc tgcggcaaac ttacggaaca acaacagcac
    10981 atcatctcca cgctcacgca aaggtggtat ctgaataggc accgtgttca accgataata
    11041 caaatcttcc cggaagcgtc cttcggcaat ggcttgtgtc aggttcacgt tggtagctgc
    11101 cacaatacgt acatccgtct tttgcacttt ggatgaacct accttgataa attcaccgct
    11161 ttcaagtaca cggagcagac gcgcctgtgt aggcaacggc aactctccca cttcatcaag
    11221 gaagatagtt ccaccgtcag cttctccaaa atatcctttc cgctcaccaa tagcaccggt
    11281 aaatgctcct ttctcgtgtc cgaacagttc ggaatcgatc gtaccttccg gtatggcacc
    11341 acagttgaca gcaatatact gcccatgctt tctccggcta tattgatgaa tgatctgtgg
    11401 aaaactttct tttccgactc cactttctcc ggtaatcagc acagacaaat cggtaggagc
    11461 tacctgaatg gcaacatcta tggcacgtga taaagcctcg gtattgccaa taataccgaa
    11521 acgctgtttc acttgttgta tctccgcttt ggtcatctat cttaatatta agtaataggt
    11581 aataagtatt aagtaataag tattaagtat taccatcatt atcatctcgc ttccatccgc
    11641 atggctaata cttaatactt attacttaat acctattact taatcttcgt ctactgtatc
    11701 cagttttagt ttatcactat cgtcccgttt ctcgtaatac tgcttccgca acgggtttac
    11761 ccgtgccgct ttctcgcgct ggcggttgcg gaatacatca atcgctacat aaatagcctg
    11821 gcggaaagag tcttcgctgg ccagtccttt accggcgatg tcataggctg ttccatgagc
    11881 cggagaggta cgtacaaccg gcagtccggc ggtatagttc acaccgtctt ccatagccag
    11941 ggctttgaac ggagccagtc cctgatcatg atacatagca aggattccgt caaagtgagt
    12001 ataattgccc gaacccataa aaccgtccgc agcataagga ccgtaacaga tgatcccttt
    12061 ctcttccatt tctttcatgg cagggataat gatttcctgt tcttccatac ctagcagtcc
    12121 gccgtctcct gcatgaggat tcagtgaaag cactgcaata cggggcgcac cgataccgaa
    12181 atcctgtttc agacaacgat ggaaaatcat cagcttttcc tgaatcagtt ccttggtgat
    12241 tgttgtagca atctccctta ccggaatatg cgtcgttact aaagccacac gaaaatcgtt
    12301 tttcatcaag atcatcagtg acttgtttcc attgcccaga cgttcttcaa tatactccgt
    12361 atgcccgggg aaagagaact cttccgactg aatcgtatgt ttgttgatcg gagctgtcac
    12421 aatgacgtcg atcagcccct cacgatactc ttctatggca cgctccaaag cacccaatgc
    12481 agccttacct gcttctggat cgggtttgga gaattccact ttcacttcgt catctgtaca
    12541 gttcactaca ctcagacggt tgtatccggc ttcggaagct gtgttgacaa tgctgaaatt
    12601 agcctgtaca tccagtgctt tacgatggta agccgctact ttaggtgaac cgtagataat
    12661 cggagtacat agctcaagca tggtagggtc tgagaatgtc ttcaagatca cttcataacc
    12721 taccccgttg atatctcctt gggtaatgcc gattcttatt ttgttttctt ccatgttttt
    12781 atttattagt tggttccgct tctctggtta cccccagtgg aatctgactc tgctgacctt
    12841 cttgcggaag tttcagcgta taaagagatg cttccatctg gcgaaccaga ttgcgtttca
    12901 ttttatcggg tgaatataca aatatttctg ctgtaataat acgttggttc ttctgatcca
    12961 gacgagtatg ggaaacgaac gggccaccca tgaagtcacc cttcatgcgc cacaatccac
    13021 gagcttccat cgtgtagtca ttgtgcacgt tgatcggacg aacatcggtc agtaacgagt
    13081 ctgtcgacat atatacgcct tctttatatc cggggatatt ggctttcatc acagaatcgc
    13141 gcttatgaac aaagtattct ttggtgaatg tatccttgtc agtataagga taagaataca
    13201 tcacgaaatt gcgatccgcg ctgcctgtat tggtagatgc ccagaagaag tcctctcctg
    13261 tcttggagtt attcagttcg gaaggtatcc agatatcgca gccaaacaga ctatctacct
    13321 tatttgagat aaagttgttg tgcttttcct ccagcaaagt aatctgacgg ttcatttcag
    13381 cgcgagtgaa gaagtcgata atcgtctgct tgttttcttc gacaaacttc tcaaacactt
    13441 cttcgttcgg agcctgaatg gtcagtatca tctgtggaga agcataaacg tctttcgcat
    13501 acttgaaagt acctttggta taaatatctt ttatatctac tatcacaata ttacggatca
    13561 acttcagcgt agaatcatag tccttcggtg aagtatacat aatccggaaa gaaggttccg
    13621 actggggcag tcccggcatg tcagaatcaa gcacatcatg caaggccctt ccggcggcac
    13681 ggtcccacac tcccgcatct actacaacca acagttcata cggacgaccg ctagaggtat
    13741 gattcccctt caatccacaa gaagcaacta cgaaggctac cagagccatg cttaaataaa
    13801 aaaagtactt tttcatgatg ttcgattttt atattaactt ttattatttt cctcctgttt
    13861 cgcagtcgac agcataccgc atgccgcaaa aatatcctct ccccgcgaag cacgaatggt
    13921 agtgaaaagc ccgtgcgtag tcagatagtc acggaaacgg gtcatcgtat ccatatcggc
    13981 tccttcaagg gctactcccg gaatagaatg gaaacggatc aggttaatcc ggcaatccag
    14041 tccgcgaagc agtttgagta actccttggc ataaacttgc gaatcattaa gccccttaaa
    14101 aacaatatat tcaaacgaaa gtcgacgctg tttgctaaaa tcatagtttt ttaacagttc
    14161 caccatttcc gtgatagaaa aggctttctc cgccggcatc agttccgcac gctgggcggt
    14221 caccggagaa tgcaggctga tggcaaggtg acagtcgctt tcttcgataa agcgccgcaa
    14281 tcctttccgc aatccgacag ttgaaacggt aatccgcttc gggctccatg cataaccata
    14341 ggaccctgtc agtatgtcca atgccttcaa cacctcttcc agattatcga gcggttcgcc
    14401 cattcccatc atgacgacat tcgtcagttt gtcccgttcc ggcaaggagt gaatctgatt
    14461 gataatctga tgggcagtca ggttggcaga gtagccttgt ttcccagtca tacagaactt
    14521 gcagttcatt ttgcagccta cctgcgaaga aatgcataaa gtcgcccgtt catcatccgg
    14581 aatatacacc gactccacaa aatgattctc gcccacaggg tacaggtatt tcaccgtacc
    14641 gtctacagag cgcatttcct ccaccggagc ttcagctcct acctcatagt tctgcttcag
    14701 taactcccgg tatttcaacg acaagttagt catttcatca atcgaagtca ccttcttatc
    14761 ataaagccag gatgcaatct gtttggctgc aaagcccggc attcccagac gtttcaccag
    14821 tgactgcagc tctataagcg tcattcctaa gaggggatat ttagacatca ttctttctgt
    14881 tcatggttta tatttgcaaa tgtaaggaaa taaagtcgat ttccgtatag caaggatgta
    14941 aaagttagca aaaaaggtcg ttccaaagca tggaacgacc ttttgcagtt atcgttttta
    15001 cgactaatct tagaagaaca ggtaacgtgt atccttcact tttcctttca gatacaggtc
    15061 gttcatcaga cggcttgcga agcgtgcgtg catattagcc aatgtagctt cttcaacttt
    15121 agcgttaaaa gtatcgctca gtttgtcttt gccatacatc tgaagcacaa atacaccggc
    15181 attacctttg attggagcac tcaatttgtt catttcagcc acagaagcat aagcacctac
    15241 cagcggttcg ctgctgcgca attcagagac ataa
//
