LOCUS       gnlProkkaMJBHDAKO_103  14295 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MJBHDAKO_103.
ACCESSION   gnlProkkaMJBHDAKO_103
VERSION     gnlProkkaMJBHDAKO_103
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 17:32:07
            Original ID  :: gnl|Prokka|MJBHDAKO_103
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 58632
            Orig. end    :: 72927
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14295
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:9295]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9295
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14295
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14295
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(961..2019)
                     /locus_tag="ctg103_59"
                     /transl_table=11
                     /translation="MKIALLTLPFVNNYGGILQAYALKHFLELRGHSVCIIDRNSNFKI
                     SFIDILRLAKRKFLGNRIRNFAYFKKQYLLPMTSEIITNKEMLLLDEKYQFDIYIVGSD
                     QVWRAIYYRDIKYNFYLDFVSSKRKISFAASFGISSWEYTNTETDIIAKLLMDFSFVSV
                     REDTAVRLCSDYLNINAVQFLDPTFLLDKNEYCCLADCFYSSKKIDIFAYIMGPDSSKD
                     KLIKIISDYSGLSVQSITQSKFSFKKNESIQEWLQNFYKSKFVVTDSFHGLAFSLIFNK
                     PFIVCGFSNRGMGRYESLLRYFSLENRLLYSLEDLKELNLSTIWDINWKEVNAKIAENK
                     RFVLELMQTVGV"
     CDS             complement(2016..3188)
                     /locus_tag="ctg103_60"
                     /transl_table=11
                     /translation="MLKVTDECTACGACLSICPKNCISFKSNEEGFLYPHIDIEKCVDC
                     DLCSKVCFLNDHITPTFRENDISYYAAKAIERCNLSSSGGIFPLLAESVLKNDGVVIGA
                     AWDDKFNVKHILIKSKSELPLLCGSKYIQSNTEKVFKIVKEHLSIQTVLFSGTPCQVKG
                     LKTFLGKDYDNLITVELVCHGVPSPLVFRRYLNGVLKYNNLDISQCSKINFREVKDDIY
                     RFVIYNKTKIPFYEQYTNLYTKTFLQNLFLRNSCYNCKCKLENSVGDFILGDFWGCRDF
                     YPEFYDPKGVSLVIVCTERAKKIWLNLKLSRIEVKKKIVFRSNRHLLKSASYNRNRDLF
                     FKTFIHEAEISLDDILMGYTNKDIWVKVKGLIISVLRFVGLFQLVQLYRK"
     CDS             complement(3172..4167)
                     /locus_tag="ctg103_61"
                     /transl_table=11
                     /translation="MCSKDNFLQEVRALCIFTVILLHVPFQGHDNISFNTWLMSKQLIT
                     FPVAVFFFLSGYFYSFRNYKSRIVKLLCPFLFWNMSVHLIKFIRGESGFNIENFLLGNG
                     LPYYYLAVLLQIVLFHYIIFKYWSEMVYRVLSISISIISLMAYYYFSISYSIHFNCYLY
                     FPFWILFYTLGTFGKKYWRNLISKIPFCVILLFILISVFLMFFEANLMYYILFQEGIAG
                     SQVKFSSWVYSILIVLLLLKIDYSIDENVTRNFGTLIGDYSYGVYLIHIFILSLIYKLC
                     IVVFNDNYNVLLPFIAASITLVISVFMIYILNKCLPPFILKFLGLYVKSN"
     CDS             complement(4170..4988)
                     /locus_tag="ctg103_62"
                     /transl_table=11
                     /translation="MLKKRLDYSQLKVIQLNILKDVDAFCRENNITYYLTYGTLLGAVR
                     HQGYIPWDDDIDIAMPRKDYEKFLSNYNLNGSKKNVYQVVAIELNNAYPYPFGKVQDLS
                     TVLLEYSDINYPLGINIDIFPIDGLPVDLKKSDKHFLKIKWLMMIMNLKKVKITIKRSF
                     LKNLILLIGKILTLLIPYRFIVCKMSYIAQRYDYEKSDYVSNLSCPDGKHERTSKRVFE
                     NSIEILFEGNNFYAPIGYHEWLHNIYGDYMKMPPVPERVSHHKFEIYKIL"
     CDS             complement(5001..6110)
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 4.5e-34.
                     Score: 109.8. Matches aSDomain:
                     nrpspksdomains_ctg103_63_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 81.8; E-value:
                     7.7e-25)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg103_63"
                     /sec_met_domain="Aminotran_5 (E-value: 5.3e-31, bitscore:
                     100.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKALSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMKSVNTVLVNK"
     aSDomain        complement(5232..6020)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg103_63_Aminotran_5.1"
                     /evalue="4.50E-34"
                     /label="ctg103_63_Aminotran_5.1"
                     /locus_tag="ctg103_63"
                     /protein_end="293"
                     /protein_start="30"
                     /score="109.8"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKALSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             complement(6107..7243)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg103_64"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.1e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.7e-20, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             complement(7255..8628)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.7;
                     E-value: 2.6e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg103_65"
                     /sec_met_domain="CTP_transf_like (E-value: 2.1e-12,
                     bitscore: 39.7, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 7.1e-122, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 4e-64, bitscore:
                     208.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKPTFRMPRSTSSAIVKNKSFPYMNKKIYVGMTADIMHPGLIHI
                     IHEATKYGDVIVGLLTDKAIAEHKRLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNL
                     EKLKPDYIIHGDDWKTGPLREVREQVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIG
                     TTPDVRLKSLRRLIQAKPVVRILEAHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDS
                     TSKGKPDIEAVDLTTRLQDLNNILECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAV
                     IIEDKVGLKKNSLFGTDAIQTQDSIEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPM
                     SDALERAYAYVQAGADGIMIHSKDKSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHES
                     ELHEWGANVVIYANHLLRAAYPAMMNVARTILENERAEEVRPLCMPIKEILELIPVTK"
     CDS             complement(8576..9295)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.5; E-value:
                     4e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg103_66"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.5e-15, bitscore:
                     49.0, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKTAMIMAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLS
                     CGIERIILGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDNFLLL
                     ESDLVFERKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKG
                     ELVGIHKLSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEI
                     DDEADLSYAEEHIIRYC"
     CDS             complement(9288..10571)
                     /locus_tag="ctg103_67"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAAFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             complement(10568..11053)
                     /locus_tag="ctg103_68"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             complement(11057..11581)
                     /locus_tag="ctg103_69"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             12103..12441
                     /locus_tag="ctg103_70"
                     /transl_table=11
                     /translation="MNDNLVTIEVNGKVIFAGKADLQFSLNQKVREPLRITKGKGKLME
                     ALTESFIKGGINSMENRPIEELQETIKEYLTFEYQRKGIATEPNKRSFLSELKKYARAF
                     RKKRDESE"
     CDS             12582..12929
                     /locus_tag="ctg103_71"
                     /transl_table=11
                     /translation="MKKNRKAVSKNEMMKGKWKRQIMLEKDYTEQCSEWMAERLEALIE
                     YMQYGHAAVAYMKQDGTFKLVKGTLVGYEKDFGKQYDPMEIKNTVVYRDVEQQRWMTFK
                     IENFMEWRAIV"
     CDS             12979..13782
                     /locus_tag="ctg103_72"
                     /transl_table=11
                     /translation="MATTYDGINYFPIAVNFMEENAMEVIEAKYGMKGLAIVLKLLCKI
                     YKEGYYIPWGEEQCLIFANKTGKEADAEEVQGIIEIMIEKGMIDRGSYAEHKVLTSEAI
                     QKVWIEATKRRKRNWTAMPYLLIKPKETCNEEKTVCTQNVEQDAGSDAKNACNTEQSKV
                     KQSREFPPSAPPRGKEEEVNATPVSMPGYAFNTMTHNYVGLMGNLERFGITDEKEIEAI
                     LRLSDYGRKGTPVWKLICSTNWSNIGAKGKYMIAALNRAKKRSGT"
ORIGIN
        1 cctgttccca tttttcagta aataataatt caaaaatttc gccagcgcta ataaaaagaa
       61 aaagcattac aggcaatact ataaagaatg tgcacataat aaccattcta tatgaatgct
      121 ttaatttttg atcatcgtct tgtaacactg ataatgcagg ataagtcaca cgttgaacaa
      181 catctgttat agaaaaagat ggaattttcg aaaacctttc tgcttgagaa tataaaccta
      241 aaacagatga agaaaagaac ttaccaatag acaatgaata caactctcct acgacagtag
      301 aaataaagcc tgtagctaat aacgtaaaag agaatggcat caaatcttgt aatttactcc
      361 atgaaattcg acatgataat ttccagtttc cataatacca taataaaagt agcctataaa
      421 aataaaatga gacattttga attaatagtg caaatatatt agggtaaaaa tacccatatg
      481 taatacctga aattgtagat aaaattatcg agaataaaga tattttagaa atagatttaa
      541 aatccatttt tttcactaat aaagtatatt ggactatact tagtgaattg atgggaaaaa
      601 tcaaaaaaga tattcttgaa attaatgtta agctaggttc tctatagaat aaagaaatat
      661 atggagccat ataaaataat attccataga gtagaactcc cataataaca ttaattataa
      721 aaattgaaga aaaatgtaaa tcatcatatt tttgtaatct tattaaagcc tgtccaaaac
      781 cactatcaag tataacttgg cctacagaaa taaaaattgt caacatgcca actataccaa
      841 aatcagaagg agatagcaat cttgccatca caatcatgta aataaattgt atcgataaag
      901 ttccaaattt ctcaaatgaa ctccacagta caccataaat tgtattttct ttaagtgaca
      961 ttatacacct accgtctgca ttaactccaa tacaaacctt ttattctcag caattttagc
     1021 attaacttcc ttccaattta tatcccaaat agtagataaa tttagttctt ttaaatcttc
     1081 caatgaatat aaaagtctat tttccaaaga gaaatatctc aataaagatt catatctccc
     1141 cattcctcta ttactaaagc cacaaacaat aaaaggttta ttaaatatta aagaaaaagc
     1201 taaaccatga aaagagtctg ttacaacaaa tttcgactta taaaaatttt gtagccattc
     1261 ttgaatactt tcattctttt taaaagagaa tttactttga gttatagatt gaacactcaa
     1321 gccagaataa tcgcttatta ttttaattaa tttatcttta gatgaatcag gccccattat
     1381 ataagcaaaa atatcaatct ttttagaact ataaaaacaa tcagcaagac aacaatattc
     1441 gtttttatcc aataagaaag ttggatctag gaattgcaca gcattaatat tcaagtaatc
     1501 agaacataac cttactgctg tatcttctct aacagaaaca aaagaaaaat ccattaacag
     1561 ttttgcaata atatcagttt cagtgtttgt atattcccaa gaagatatgc caaaagaagc
     1621 ggcaaaggat atcttcctct tactcgacac aaaatccaaa taaaaattat atttaatatc
     1681 tctataatat attgctctcc aaacctggtc actaccaaca atataaatat caaattgata
     1741 tttttcatca agcaataaca tttctttatt agttataatc tcagatgtca ttggtaataa
     1801 atattgcttc ttaaaataag caaagttacg aattctattt cccagaaact tcctttttgc
     1861 aagacgtaat atatcaataa aacttatttt aaaatttgaa tttctatcta taatgcaaac
     1921 actatgccct cttaactcta aaaaatgttt taaagcataa gcttgtaata ttcctccata
     1981 attattaaca aatggtaaag taagtaatgc tattttcatt ttctatacaa ttgaactaat
     2041 tggaaaagcc ccacaaaacg taaaacacta attatcaaac ctttaacctt aacccaaata
     2101 tccttatttg tgtatcccat caaaatatca tctagtgata tctcagcctc atgaataaaa
     2161 gttttaaaga acaagtctct atttctatta taagatgcag attttaataa atgcctatta
     2221 cttctaaaaa caatcttttt cttaacttct attcttgata attttaaatt taaccatatt
     2281 ttttttgcac gttcagtaca aacaataact aagctaactc cttttggatc ataaaattca
     2341 ggatagaaat ccctacatcc ccaaaagtct cctaagataa aatctcctac ggaattttcc
     2401 aatttacatt tacagttata acaagaatta cgtaagaata aattttgaag aaatgtttta
     2461 gtataaagat ttgtatattg ttcataaaat ggtattttgg tcttattata tatcacaaat
     2521 ctatagatat catcttttac ttccctaaaa ttaattttac tacactgtga aatatctaaa
     2581 ttattatatt tcaaaacccc attcaaatac cgtctaaaaa ccaatggtga aggaactcca
     2641 tgacaaacca attcgaccgt aatcaaatta tcataatctt ttcccaaaaa tgttttaagt
     2701 cctttcactt gacaaggtgt tcctgagaaa agaacagttt gaatagacag atgttcttta
     2761 actatcttga agaccttttc tgtattactc tgtatgtatt ttgaaccaca taataatggc
     2821 agttcacttt ttgatttaat aagaatatgt ttgacattaa atttatcgtc ccaagcagct
     2881 cctattacta cgccgtcatt cttcaaaact gattctgcaa gcaatgggaa tattcctcca
     2941 gaagagctca aattacatcg ttcaatagcc ttagccgcat aataactgat atcattttcc
     3001 ctaaaagtcg gagtaatatg atcatttaaa aaacaaactt tagaacacaa atcgcaatct
     3061 acacattttt ctatatcaat atgtggatat aaaaaacctt cttcattact tttaaaagaa
     3121 atacagttct ttggacatat agacaagcaa gctccacaag ccgtacattc atcagttact
     3181 tttaacatac aatcctaaaa atttaagtat aaagggagga agacatttat ttaaaatata
     3241 aatcataaaa actgaaataa ccaatgttat agaagctgcg ataaaaggca ataatacatt
     3301 ataattatca ttaaaaacga caatacataa tttataaatt aaagataata taaatatatg
     3361 aattaaatag actccatatg aatagtcacc tataagtgta ccaaaatttc gagtaacatt
     3421 ttcgtctatt gaataatcta ttttaagtaa aagcaacaca attagtatag aatacaccca
     3481 ggaagagaac ttaacctgag agccggcaat tccctcttga aacaaaatat aatacattaa
     3541 attagcttca aaaaacatca aaaagacaga tattaaaata aacaatagaa ttacacaaaa
     3601 aggtatttta gatattaaat tacgccaata ttttttccca aatgttccta aagtatagaa
     3661 taatatccaa aagggaaaat agagataaca attaaaatgg atagaataag aaatggaaaa
     3721 ataataatag gccatcaaac ttataatact aatacttatg gacaatactc tatataccat
     3781 ttcgctccaa tatttaaaga ttatgtaatg aaataacaca atctgaagaa gtactgctaa
     3841 ataataataa ggtaatccat tacctaataa aaaattttca atattaaatc cgctttcccc
     3901 tctaataaac ttaattagat gtacactcat attccaaaat aaaaaaggac aaagcaattt
     3961 aacaattcta ctcttataat ttctaaaaga ataaaaatat ccagataaaa agaagaacac
     4021 agcaacaggg aaagtaatca actgctttga cattagccaa gtattaaaac ttatattatc
     4081 atgtccctga aatggtacat gtaacaatat tacagtaaat atacataatg cacgaacttc
     4141 ttgaagaaaa ttatccttag aacacatgat tacagtatct tataaatttc aaatttatga
     4201 tgagatactc tttccggaac tggaggcatt ttcatataat ctccataaat attatgaagc
     4261 cattcatgat atcctatagg agcatagaaa ttattacctt caaataaaat ctctatacta
     4321 ttttcaaaaa ctcttttaga cgtccgttca tgtttcccat ctggacaaga caagttagaa
     4381 acataatcag atttctcata atcatacctc tgtgcaatat aagacatttt gcacactata
     4441 aatcgatatg gaatcaaaag tgtcaaaatc ttccctatta ataatattaa gttcttcaaa
     4501 aaagaacgtt ttattgtgat ttttactttt ttaagattca ttatcatcat taaccacttt
     4561 atcttcaaaa aatgtttgtc tgatttttta aggtctacag gtaatccatc aatagggaaa
     4621 atatcaatat ttatccccaa cggataatta atatctgaat attctaataa aacagttgat
     4681 aaatcttgaa cctttccaaa aggataagga taagcattat ttaactctat agcaacaact
     4741 tgatacacat tttttttact tccatttaga ttataatttg ataaaaactt ttcataatct
     4801 ttcctcggca tagcaatatc aatatcgtca tcccaaggaa tatatccttg atgtcttaca
     4861 gcccccaaca aagtcccata agttaaataa taagttatat tattttcacg acaaaaagca
     4921 tctacatctt ttaatatatt caactgtata acctttaatt gggaatagtc caaccttttt
     4981 ttcaacatga atgagctaaa ttatttatta actaataccg tatttacgct tttcatcacc
     5041 tcaaagaacc tctcaatatc ctccacatca atctctccca acgcacaaag ccggaatgta
     5101 ttcgttgtgg aaatcttacc cgggtagatc gtaaagccac gttcatagca gtaatcatga
     5161 accttatcaa aatcccagag gggatcatca ggatacaata cagaaacaac aagacccgac
     5221 tgccattcac gtttgatcgc atactgaaga ccaagctctt gcaaaccttt atggatggct
     5281 tcaaagaccc tcttgtgacg ggcgaattta gcctcttcac ctactgcaaa atattcatca
     5341 agagcctgac gggctgcgta aacggtttga acaggaggag taaaatgcat ctcacccgtc
     5401 ttctcaaagt aatcgtattg taaatagagg ttacaatagt aggagcgttt cggataatcc
     5461 cttgaagcac gtatcaggga ttcatcacct atgataaagg aaagacccgt catggcctga
     5521 aggcctttct gagccgaagc catacaaaag tcaacattat cctttccgat atcaaaagga
     5581 atcataccca gggaggaagt ggtgtcgaca acaaaaacgg caccgtgcga atgggctatt
     5641 tttccgatct cacggatggg gttcaagata cccgtacccg tttcatggtg cgtggtatag
     5701 accaaagcga tgtccggatt gtcggaaagc gccttttcga ttaccgacag gtcgggaagt
     5761 tcgtaaacgg aaaacttcaa atcgatatgg ggaagaccgt aatattcgca gacttccacc
     5821 gcacgggtgc tgtaggcacc gttattgacc accagaactt tcttatccgc aggaagaaga
     5881 gagttcaggc agatatcgat attgatcgta cccgagccgc aaaacaggac ggccgtatgt
     5941 ttggaaaggt ctccatgcgc aacgcggacc aggtcgtcac gtaactgttt catcataccc
     6001 gcaaactctt tctcacgcgg acagatatcg ggaacaacct gcgccagctt caccgtatcc
     6061 gtcgtggtgg cgggacccgg attcaaaagg atctttcttt cgatattcat gaatgcgtat
     6121 cttttaaaaa tgccataaaa tgctctttat tctctaccgg agtagtcgta gggcgaccca
     6181 gatcatcacg tgaatcgatc cggaccttaa tttcaagaag aaccgggccg gacaggccgg
     6241 acagcttctc aagcgcacac gaaagccctt ccttgtcgga ggcagtcagt acatgcgcat
     6301 aaccgcaacc tttcgctatc gaggcgatat ccagacggaa accgagcgtg ggttgaccgc
     6361 cgacagattc atgcgcaccg ttgttgaaaa ggacgtgcct gtaattcttg ggagaaagat
     6421 cgccgatatt gctgacagca cccatgtgca tgataaaggc accgtcaccg tcaagacagt
     6481 agacacggcg gtcaggcttc tcaagggcaa tccccagggc aatggaagaa ctgtgaccca
     6541 tggaacccac agttaggaaa tcccttgcgt gcccctgccc tttcgattca cggtactcga
     6601 aaagctcacg ggagagcttg cccgtggtgg aaaccacaat gtcattgtcc ccgaggtggt
     6661 cgacaacctg cattagcgcc tcctcgcggg acagaggata gtcattcaag gcttcctgac
     6721 gcaatttata ttttccaaac gtatctttac ggatgacaat cgcatgggga atcgaccggc
     6781 tcttcgccga gacaaccgcg tcatggatct gcgccagggc ctcgtcttca tccgtatcca
     6841 gaattataaa aggaattttc atggctttca gaagatcaag ggtaacctcg ccctgcttct
     6901 tatgctgggg ttcgtctttt gtgccgggct caccgcgcca gccgaccagc aaaagaagag
     6961 gaaggctgta cactttctcg tccgcaaggg acaagagggg attcaccgta tttcccagac
     7021 cggagttctg catataaacc aaaggaacgt tgccagaagc catataataa ccgcaggcaa
     7081 tgcccaccgc ggaaccttca ttagcggcga tgatatgctt accacgcgga gcatgatccg
     7141 tgatataggc gcaaatattc ttcaaaaggg aatcgggaac acccgtaaag aagtcaacac
     7201 cgtgatgaag gaacgtatcg tatatctttt ctacacttac cataaccgtc tgatttattt
     7261 agtgaccgga atcaattcca gaatttcctt gataggcata caaagcggac ggacctcctc
     7321 ggcgcgctcg ttttcaagga tggtcctggc cacgttcatc atggccggat aagcggcacg
     7381 gagaaggtgg ttggcgtaaa tgactacgtt ggcaccccat tcgtgaagtt cggattcgtg
     7441 cacatggtca taagtcgtcg gaacaacgac aatgggaaca tgggcgtatt ctttgcggaa
     7501 agtccggcag aactcacgga tatcctcacc cgacttatcc ttgctgtgga tcatgatgcc
     7561 gtccgcaccc gcctgtacat aggcataagc acgttcgagg gcgtcactca tgggtttgcc
     7621 ggcaataagg ctttcgatac gcgcaatgat cataaagtca ccggtgacct gggcattctt
     7681 ccctgctctg atcttatcgc agaaaccctc gatactatcc tgagtctgga tagcgtcagt
     7741 accaaaaagg gaattcttct tcagaccgac tttatcttca atgattaccg cagaaatgcc
     7801 gtgacgttcc agagtgcgca cagtaaagac aaagtgttcg atcttgccac ccgtgtctcc
     7861 atcaaaaata ataggcttgg tggtacattc aaggatattg ttcaggtcct gtaaacgggt
     7921 ggtaaggtcg accgcttcaa tatccggttt acccttactc gtggagtcgg tcaggctgct
     7981 ggaccacatg ccgtcaaaga cctcgcgctt atcacccttc tggacttcaa gattctcaat
     8041 aatcagaccg caaagaccgt cgtgagcctc caggatacgg accacaggct tggcctggat
     8101 caggcggcgg agggacttaa gacgtacgtc aggggtagtc ccgatcgcct tgatatcctt
     8161 gtcgagcgag gaggagttga tgccccgggt ataagggatc tcgattacct tgcccccctg
     8221 ggcgttcatc acctcaaaaa cctgttcgcg cacctcgcgc aacggacccg ttttccagtc
     8281 gtcaccgtgg atgatatagt caggcttgag tttttccaga ttcggaacat agctccaatc
     8341 ctcctgggga acaacctcgc aaaccccctt gatattctca acaacctcct tacgctgatc
     8401 ataggtaagg taagggaggc gtttgtgttc ggcgatggcc ttgtccgtca gcagaccgac
     8461 gatgacatca ccgtatttag tagcttcatg aataatatgg atcagccccg gatgcatgat
     8521 atccgcggtc ataccgacat agattttctt gttcatatat ggaaaagatt tgtttttaac
     8581 aatagcggat gatgtgctcc tcggcatacg aaaggtcggc ttcatcatcg atttcatacc
     8641 atttaagacc ctccaccctg agcacacgga caggggaaac ggaacgggac atgcggagca
     8701 gttcgtactc gtaacccagt ttaggctggg actccaggat ggtcgcataa tcggcgcaca
     8761 tccggcggta gaaagtattg gaaagtttat ggataccgac cagctcgcct tttgcctcaa
     8821 gggcgttctt gtctaccgaa caggaagtaa ggatgtgatt gcggtcatat tccacataat
     8881 actgatcctg gaacttggtc agagaagaga caagcatcac atccgggaat tcgtcatcca
     8941 gtagcgagag gatggccttg cgttcaaaaa caaggtccga ttcaagcagc aggaaattgt
     9001 catcgcctat cacgtcacgc gtattgtaca gagtgtacat actgttagta tcggcataac
     9061 ggggactgaa acaggtctct atctggggga aatccgcctg aagggcttca taagcctctt
     9121 ttttataacc cgtaccgagg atgatacgtt cgataccgca ggaaagaagg gtttcgatag
     9181 agcggataat cataggtttt ccaccaacct ccacaaaacc tttgggcaca agctcggtat
     9241 aatgcccgaa gcgggtacca agaccggcag ccatgatcat tgctgtttta atcatgaatt
     9301 tcagagggaa ttaatataag tgaattcaat tgttgcttga aataacagta aatcgcaaaa
     9361 atcgacagga cagaaacaaa tcctgaaaaa agggcagtac gcattagcat gacagtccag
     9421 gaaatgtcag cagaaacgaa gttcttgacc ataaacacac ccgtagtgcc cagatagccg
     9481 aaagaatcgg ccaaataaat aataaaaaca gccgtactaa ccaccctaag ggaagcaatc
     9541 aggcgttcta tcaggtaagt gaaaggaata taccccatat acagaccaag accggaaaga
     9601 atcatccacc aaataggaga aagaaaaccg tacacataaa gcaatgtgga aaaaaccatt
     9661 aaggaaccgc ctgtgacggc aatgcaataa atgatattaa gagccaaacg gttattacgg
     9721 acaaacacaa tcaggaacat cagtacaagg acaaaagcgg caatgggaac ctctgtctga
     9781 gtaaagatca ttgcaccctc aatatggagc tccttccaaa tatcggcagc gaaagagtca
     9841 cgaagctcac ggaacacggt cagggcaccg taaaaaacaa ccagcatgca gattccccag
     9901 aagaattgcc tcaaaaattt acgcctgtct ttaccatcca tcggagcacg tttggtacgc
     9961 tgtatgatat cttgctcatt gggagccgga atctgattga gaagccagct gcaaagcaac
    10021 ataacagggt ataccaacaa accggtggta aaaggcatcc aatattccga cacatgcaaa
    10081 ttatccatca cgaattgtcc caaggttttc accaaaccgg aagagactat caaagcaacg
    10141 ctcagcccga cattcaatat ttcactgata cgacgtcctt cgatatagct aaaaatgaca
    10201 ccccagatca tacccagggg aagaccgctc agaaaaatag aacacacctt caaaggaacc
    10261 ggaagaagtg caaaacccaa caaagcaact tcggaaaaag taagcagccc tattatataa
    10321 tagatgcggt gacccgcttt catcgaaggc agaatacgaa caccgatgaa cttggaaagg
    10381 gcgtagccga taatctcaga aaggacatac aggattttga catcgaatcc ccaaagaatc
    10441 tcaccttcat aaatggctgc ggtaaatggc ttacggtagg cataggcaca agtataaacc
    10501 agaaaaatca aaacgctggc atagagagcc aaaacgtaaa ggggagaacg ggaaagaaag
    10561 gaacgaatca ttcgtgtagt tcgctgtacg gatatggatt agcttccaaa ttattcaaac
    10621 tttcagctat ttctttttca gcttttaaaa gttctcgatt gctccaactt tctatgatag
    10681 tatgcgcctc tttcgccaac tcctcttcaa acacctcacc ataacaataa gtcaacaact
    10741 ggcatttcaa taaagtagca ggaagttggt caagcacgtc ccaacaacga ttgagaacaa
    10801 cttgcttttt ctcctccttg tcaccctgat tatagatggt tgcattgtaa cccatcaata
    10861 atgccagaca gatgtttgct tcctcttcgg gagtagcacc acgctgagga tacaacgcat
    10921 cggattgttc taaaacttct ttgttcaact gacggaaatg atcggtataa ataggagcac
    10981 catccacacc taaatagagt aactcgtgcg cgagactctg taattgttca atttgagaag
    11041 tgagtgtatt cataacttaa atgacacgta aataactttt aggaactttg acgctggcgc
    11101 tcaatacacc ggcaatacga ataacaacat aagttttgtt ggcctcgctg gcaagttcgc
    11161 cctcgacacc acagaaatca cctttaacta cctgaaccct gctaccgaca gataaatggt
    11221 cattatcgaa actgacgcca ttcggatcta aatccatgac aaatatgaag tcctgcatct
    11281 gtttatcagg aactatcagc atagccctgg taagcaggtc tttcatataa aaaagctgga
    11341 tattgtattt attagaaata tcacaagcat cttgcttggt agcttggatg aagataagat
    11401 tcttaataac agggacttcc acccgttttc gacgatattt caactgccgg atgacaaact
    11461 gagtgggaag atagtaattg agatcaagtt cagtcttcaa tttttcaaga gagtcacgaa
    11521 tagcaaactc ttgtttatct cgggtacggg cggcaaacca atacttctgt tgttcagaca
    11581 tttacgattt atacttgggg aaattttcct ttatttcggg tgcgcttcgc ggtttgaacg
    11641 agacatcttt tctctttcaa accgtcaaat tttacgaaac atttttagaa gttgagaacg
    11701 aacgaatgtg tttcaaaaaa cgttcgtctt ttgaaacagc atttttgagt tttttttcga
    11761 tgaaaaaatg aatattgtaa agtagctgaa caaagaactt tttttgctct atatatattt
    11821 gagaatcagc aacataaaat ctttgataaa attttatcca ctaaatattt tgtacattaa
    11881 aacagactcc ttacctttgt tcaatcaaac gaacgttttt tgaaacaacg cctatatctt
    11941 aagataaata actaataaca agatccttac acttcaagat tctcccttta aactaaaaaa
    12001 actccggtat tcttttatat ttatattttt ttatacaaac tttgtccttt cataaattca
    12061 tttaataact aacattatgg aagaaaaaaa gtagttatct cattgaatga taacttagta
    12121 accatcgaag taaatggaaa agtaatcttt gcgggtaaag ccgacttgca attcagcctc
    12181 aatcaaaagg ttagagaacc actacgcatc acaaaaggca aaggaaagct aatggaggca
    12241 cttaccgaaa gctttatcaa aggcggaatc aacagcatgg aaaacagacc cattgaagaa
    12301 ctacaggaaa caataaaaga atatctcacc tttgaatatc agcgcaaagg cattgctaca
    12361 gagcctaata aacgttcttt tctatcagag ctgaaaaaat atgccagagc attccggaaa
    12421 aagcgagatg aaagcgaata accgattgtt aaaatcctgt aaaagcccct ttctaaagta
    12481 cttttacagg attagtctat tcaaaactta ttaccgtact ttgccatggg taaaaataaa
    12541 agcccgacaa taactcatta ataaacttta aaaaatcaat tatgaaaaag aacaggaaag
    12601 cagtatcgaa aaacgaaatg atgaaaggaa aatggaaaag acaaatcatg ctcgaaaagg
    12661 actacacaga acagtgctcc gaatggatgg cagaacgact ggaagccctc atagaatata
    12721 tgcaatatgg acatgcagcc gtagcttata tgaaacagga cggaacattc aaactggtga
    12781 aaggaacatt ggtgggatac gaaaaagatt tcggaaagca gtatgatccg atggaaataa
    12841 aaaacacagt ggtctaccgg gatgtggagc aacaaaggtg gatgaccttc aaaatagaga
    12901 atttcatgga atggagagcg atcgtatagg agaatctttc agtgaccaat taatcagcaa
    12961 cataacaact taacaattat ggcaacaaca tacgatggaa taaattactt tccaatagct
    13021 gtgaatttta tggaagagaa cgcaatggag gtaatagaag caaaatatgg catgaaagga
    13081 ctcgcgattg tactgaaact tctatgcaaa atatataaag aaggatatta tattccgtgg
    13141 ggtgaggaac aatgccttat tttcgccaac aagacgggaa aagaggcaga cgcagaagag
    13201 gtgcagggga ttatcgagat aatgatcgag aaaggaatga tagacagggg aagctatgcg
    13261 gaacataaag tactgacctc tgaagcaata caaaaagtat ggatagaggc aaccaagcga
    13321 agaaagagga actggacagc catgccttat ctactgataa aaccgaaaga gacatgtaat
    13381 gaagaaaaga ccgtctgcac gcaaaatgta gagcaggatg caggctctga tgcaaaaaat
    13441 gcatgcaata ccgaacaaag taaagtaaag caaagtagag aatttccccc ctcagctccc
    13501 ccaaggggga aggaagagga agtcaatgct acgccggtca gtatgcccgg atacgcattt
    13561 aatacaatga cacacaacta cgtgggatta atgggaaacc tggaacgatt cggaataaca
    13621 gacgaaaaag agatcgaagc aatcctgcga ctgtcagatt acgggagaaa aggaacccct
    13681 gtatggaaac tgatttgcag cacgaactgg agtaacatcg gagcaaaagg aaaatacatg
    13741 atcgcagcgt tgaaccgggc aaagaaaaga agcggaacct aaaaaagaac ttttctgaca
    13801 aacagtacat tttatattct ggaaaatgct gtttgcttgc aatcaattaa agaacgcagc
    13861 tgttttcctc cggaaacgga cactgattct caaggggttg aaaagcgatt caaaaagcac
    13921 taatacgaag ttaaaatcgt gacttcagga agttaacttc ccgaagatac gattttaact
    13981 tcgtaaaatt atgatattaa cttcgtaaac aacaagatgt taacttcgta aacggcatca
    14041 tccggacatc aaagcaatca aaaaagattg tcagactata gtatttcagt cagttgccag
    14101 acttgtatgt gacgaatccc ttctttggag ggcaatgtgg tatcgtccat agaaacgacc
    14161 cacttttcat aattgtcttg tatcatctcc agcgtgttgt acatttgctc cacttgaaaa
    14221 tcatcattga gcagaggtgc acattgcaaa tacacaatgc ggtctttctt cctgccaaca
    14281 aaatcgacca gtttg
//
