LOCUS       gnlProkkaALHIGKOD_67   14727 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ALHIGKOD_67.
ACCESSION   gnlProkkaALHIGKOD_67
VERSION     gnlProkkaALHIGKOD_67
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 17:13:44
            Original ID  :: gnl|Prokka|ALHIGKOD_67
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14727
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14727
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4379:4727]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4380..4727
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14727
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14727
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             67..900
                     /locus_tag="ctg67_1"
                     /transl_table=11
                     /translation="MTTKKLTGILSLFLCIICLVSCNDNDDNFSPITLEYEDPQIKFDN
                     ESRSYTLTPFSKETTPLFIKGGDGTYKVTNENEKVVQVNYHNGSLTLKAKEIGRASIKI
                     EDSSNNMYILSVVVKYRTLTHKAFTAKVIVKGDELTSEEHTELMNKVGNSYPINKYVFT
                     FMNAEDSKGTVDLYYSDNNMKTGNFEKEHIVLDEENAIPIKGEYKLSEYYRITIKEDNG
                     KVIDTFYITKNFLPLLNTRMNAHPLIQYCFVRDLTAQYKQDYLALENAYLIQIAE"
     CDS             1432..2943
                     /locus_tag="ctg67_2"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITNRWNP
                     ETPVTIFAGPGNNGGDALAIARMMAEKGYKIEVYLFNTKGELSPDCQTNKELVEMMEEV
                     TFHEISTQFVPPTLTPEHLVIDGLFGSGLNKPLSGGFAAVVKYINASPAMVVSIDIPSG
                     LMGEENTFNVKSNIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEEGIEETET
                     NYEMLEIEEIRSLIKPRQQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPLCNNDILQTSAPEAMVETDVSETCFAVPTDTDDYQAVGIGPGLGRSEETEAALIEQ
                     LEHCQTPTVLDADALNILANHRHTLTHLPKGSILTPHPKELERLVGKCQDSYERLMKAC
                     ELAHTAKVHIILKGAYSAIITPEGKCYFNQTGNPGMATGGSGDVLTGVILALLAQGYPA
                     EDAAKIGTYIHGLAGDIAQKKQGMIGLIASDIVTCLPTAWQLVSE"
     CDS             3017..4081
                     /locus_tag="ctg67_3"
                     /transl_table=11
                     /translation="MKKLIIATGLLMATSAYAQTEVLTGVTRGKDYGVVYALPKTQIEI
                     EIKANKVNYKPGEFSKYADRYLRLTNVSAEPEEYWELNSVKVKPVGVPNSEATYFVKLK
                     DKTVAPLMELTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMFSGVRNK
                     EEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIPQEDGKK
                     KKEMEGIAYNVPGQAMVTLTDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     VTGGLLKVDREESK"
     CDS             4103..4390
                     /locus_tag="ctg67_4"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLKDGKEASRLRRERRNDKLGRLRRNNDPYLLP
                     DTTPEEMERIIKDSEKKKEKDNSYFVWGTLIIMGVLIGCAVLLWAIFFNG"
     CDS             complement(4380..4727)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg67_5"
                     /sec_met_domain="PF05402 (E-value: 3.8e-17, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 1.4e-09, bitscore:
                     29.0, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEQEGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQYEAGYESRVSTYLSQLQ
                     KDGFIKWIIIH"
     CDS             complement(4772..6160)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 91.3; E-value: 8.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg67_6"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(6451..6846)
                     /locus_tag="ctg67_7"
                     /transl_table=11
                     /translation="MYLLFIILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSVATAYVVPSSSAAKDVLLEQAQKEQQTNPYNMPTGTAAP
                     QTDATAPAESAPATEAPATETPAPAAE"
     CDS             complement(6853..7626)
                     /locus_tag="ctg67_8"
                     /transl_table=11
                     /translation="MTSVNLQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETIKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(7631..8158)
                     /locus_tag="ctg67_9"
                     /transl_table=11
                     /translation="MNWIKKIARPLILVVLPAVIIACSVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(8145..9386)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 388.8; E-value:
                     6.1e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg67_10"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFAADFAEKYRMPAIQLTEDAKKI
                     LLAYPWPGNVRQLKNITEQISIIETNREITAAILQTYLPAQNTQRLPALFGTRESKSFE
                     SEREILYSVLFDMRQEVAELKKMVHNMMAERAGQVGQMGQVVATPVVTTTHQPSVPAII
                     HAVQQPSVCPKEDDDDIQDTEEYVEETLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(9510..10604)
                     /locus_tag="ctg67_11"
                     /transl_table=11
                     /translation="MEENKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDVQANFSIVNTASEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGDGNKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEIIIPAMKEMEEKGIICYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLASEDSFRQAIYVAIDVFRNRQREKAARVN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(10609..11646)
                     /locus_tag="ctg67_12"
                     /transl_table=11
                     /translation="MKKYFFYLSMALVAFVVASCGLKGNHTSSGRPYELLVVVDAGVWD
                     RAAGRALHDVLDSDMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIVIVDIKDIYTKGTF
                     KYAKDVYASPQMILTIQAPNEEVFEKFVEENKQTIIDFFTRAEMNRQITLLEEKHNNFI
                     SNKVDSLFGCDIWIPSELNNSKTGEDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGYKEGVYMSTDSLLTDVRPINVHNDYTMEARGLWRMKGDFMGGPFV
                     SHTRLDQKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPQEGQQSQIPLGVTKEA
                     EPTNK"
     CDS             complement(11664..12701)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg67_13"
                     /sec_met_domain="PF04055 (E-value: 3.2e-17, bitscore: 54.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMSKYPLLGMTLIELQSLVKRLGMPGFAAKQIASWLYDKKVTSID
                     EMTNLSLKYRELLKQNYEVGAEAPVEEMRSVDGTVKYLYPVGENHFVESVYIPDDERAT
                     LCISSQVGCKMNCKFCMTGKQGYSANLTAHQIINQIHSLPERDKLTNVVMMGMGEPLDN
                     LEEVLKALDILTGSYGYAWSPKRITVSTVGLRKGLRRFIEESDCHLAISLHSPVTAQRA
                     ELMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCR
                     INLIRFHSIPGVALEGADMDTMTRFRDYLTTHGLFTTIRASRGEDIFAACGMLSTAKQE
                     ENNKS"
ORIGIN
        1 tttaaacaaa ttattaatca gaattctgtt gcatttgcaa gttgaattca gcaaacttta
       61 attagcatga ctaccaaaaa actaacagga atactttcgt tattcctttg tattatttgc
      121 ctcgtgagct gtaatgacaa tgatgacaac ttttctccaa tcactctgga atatgaagat
      181 cctcaaatta agttcgacaa cgagagccgt tcttacacac tgactccgtt cagcaaagaa
      241 acgacaccac tcttcatcaa gggtggagac ggaacttaca aagtgaccaa tgagaatgag
      301 aaagtggtac aagtaaacta ccacaacgga agtttaacat tgaaggcaaa ggaaatagga
      361 cgcgcatcca tcaagataga agacagttcg aataatatgt atatactgtc tgtcgttgta
      421 aaatatcgta ctcttactca taaggcgttt acagcaaaag tcattgtgaa gggagacgag
      481 cttacatctg aagaacacac tgagttaatg aacaaagtgg gcaattcata tccgattaat
      541 aaatatgtat ttacttttat gaatgcggaa gacagcaaag gaacagtaga tttgtattat
      601 tcagataata acatgaaaac aggcaacttt gaaaaagaac atatagtgct ggatgaagaa
      661 aatgccattc ccatcaaagg tgaatacaaa ttgagtgagt attaccgtat aacaatcaaa
      721 gaagataatg gcaaagttat tgatactttc tatattacca agaactttct accactcctc
      781 aatacaagaa tgaatgctca tccgttaatt cagtactgtt ttgtcagaga tttaaccgca
      841 cagtacaaac aagattacct tgcactggaa aatgcatatc tgattcaaat agcagaatga
      901 gaactacact gattttcttc tttagcagag tgaatagagt atttattata tgagcaaact
      961 ccccattaga tttagcaaaa aacaataagc tattagctaa tcaagaatat gcccatagca
     1021 tatttatcac aatcacctct tccacccttt tcctgaacct ttgatgaata aggcgattgc
     1081 gggtgaaaga ggtgaaccag aggaatatac agtagtagaa acacgcatgg gaaggttaac
     1141 aaacagccat gaatgttctc cggagagagt aaaagtaaat gagataacaa tgcttgccat
     1201 actgcgttac aagcattgaa agccatcata acaagcattg atatctacca taacaatcat
     1261 taatatctga cttctcaact attaataact gacacatcaa ctattaatac ctgacaactc
     1321 aagtattaat acctgaagtt ccttcccaaa aagccgaaaa ccaaccggaa taaaggatta
     1381 attcagagtt tttgtgtaag tttgtgcgtc gaaaactaaa agaatatcgc aatgaaaata
     1441 tttccaagca gcagcattaa gaagttagat gcctatacca ttgaacatga accgattgca
     1501 tccatagatt taatggaacg tgccgcacag gcgctgacta aagccatcac caacagatgg
     1561 aatccggaaa cacctgtcac catctttgcc ggaccgggca ataatggcgg agacgccctc
     1621 gccatcgccc gcatgatggc ggaaaaagga tacaagatcg aagtatatct cttcaacacg
     1681 aaaggcgaac tttcgcccga ctgtcagacc aacaaagaac tggtagagat gatggaagaa
     1741 gtaactttcc atgaaatcag cacccagttc gtacctccca cactgacacc ggaacatctc
     1801 gtgatcgacg gattattcgg ttccggactc aacaaaccat tgagcggagg attcgctgcc
     1861 gttgtgaaat atatcaatgc ctctcccgcc atggtagtct ccatcgacat cccttccgga
     1921 ctgatgggag aagaaaatac attcaatgta aaaagcaata ttatccgtgc ggacgtcact
     1981 ttcagcctgc aacttcctaa actggccttc ctctttgccg aaaatacaga atttgttggc
     2041 gaatgggagt tattggacat ccagctgagc gaagaaggaa tcgaagagac tgaaacaaac
     2101 tacgaaatgc tggaaatcga agaaatccgt tcgctaatca aaccacgcca acaattcgcc
     2161 cataaaggaa acttcggaca tgccctgctg atagccggct caaaaggaat ggcaggtgca
     2221 tcggtactgg ccgcccgtgc ctgtctgcga tcgggagtag gtctgctgac cgtacacgcg
     2281 ccgttatgca acaacgatat tttgcaaacg tccgcccccg aagccatggt agaaacggat
     2341 gtcagcgaaa catgctttgc cgtacctacc gatacggacg attaccaagc tgtcggcatc
     2401 ggtccgggac tcggtcgcag cgaggaaacg gaagccgccc tgatagaaca actggaacat
     2461 tgtcagactc cgacggtact ggatgccgac gcactcaata ttctggccaa tcaccggcat
     2521 acgctcaccc atctgccgaa aggttccatc ctcacccctc acccgaaaga gctggaacgc
     2581 ctggtcggca aatgtcagga ctcatacgaa cgactgatga aagcctgcga actggcgcac
     2641 actgccaaag tacatatcat tctgaaggga gcttattccg ccattatcac ccccgaaggc
     2701 aaatgttact tcaaccagac cggtaatccc ggtatggcaa caggaggcag cggagatgta
     2761 ctgacaggag taatccttgc actccttgcg caaggctatc ccgccgaaga cgccgcaaag
     2821 atcggtactt acattcacgg attggccgga gacatcgccc agaaaaaaca gggcatgatc
     2881 ggattaatcg caagtgatat cgtcacctgt ctgccgacgg catggcaact tgtaagcgaa
     2941 taaaagttaa gaacttacgg tttattcaat aacttcatta actttgtttt tcaaaatcag
     3001 ctaaaaagaa ccgaatatga aaaagttaat catagcaaca ggactactaa tggcaacttc
     3061 cgcctatgcg cagaccgaag tgctgacagg agtgacgcga ggaaaagact acggagtagt
     3121 gtacgccctc cccaaaaccc agatagaaat agaaataaaa gcaaacaaag tcaactataa
     3181 gccgggtgaa ttcagcaaat acgccgaccg ctacctgaga ctgaccaacg tctctgccga
     3241 acccgaagaa tactgggaac tgaacagtgt caaagtgaaa cctgtaggtg taccaaacag
     3301 cgaagctact tatttcgtca aactgaaaga caaaaccgta gctcctctta tggaactgac
     3361 tgaagagggt cttatcaaat caatcaacgt cccctacagc agtaacaatg caaagaatgc
     3421 agcaaacaat gccgttgctc cccaacgaaa agccaatccc cgcgactttc tcacagaaga
     3481 aattctgatg gcaagttcaa ccgccaagat ggccgaactg gtagcaaagg aaatctataa
     3541 tatccgcgaa agtaaaaacg cattattgcg cggacaagca gataatatgc cttcggacgg
     3601 cgcacagctc aaaatcatgc tcgacaacct gaatcttcag gaagaagcca tgaccgagat
     3661 gttttcggga gtccgcaata aagaagaaaa gacatttact gtccgcctca ctccggataa
     3721 ggaattcgac aatgaggtag ctttccgctt ttcaaagaag ctgggtatag ttgccaacaa
     3781 cgatttggca ggcactccat tctacatcag tctgaaagac ctgaaaacgg tgaagattcc
     3841 gcaagaggac gggaaaaaga agaaagagat ggaaggcatt gcttataacg taccgggaca
     3901 ggcaatggtg acgctgacgg acggcaaaaa gaaattgtat gaaggagaaa tacctgttac
     3961 tcagttcggt atcatagaat accttgctcc ggtattattc aacaagaact cgaccatcaa
     4021 agtttacttt gatccggtga ccggtggact actgaaagta gatagagaag aaagcaaata
     4081 aaacctctaa aaaaacaaaa cgatgggtgg cgaaggacat atgctcgaca tgatacgtcg
     4141 gctgaaagac ggcaaagaag cctcccgctt acgccgtgaa cggagaaatg acaagttagg
     4201 gcgacttaga agaaacaacg acccttatct tctgccggat acgactccgg aagagatgga
     4261 acgcatcatc aaggattcgg aaaagaaaaa agaaaaagat aacagctatt tcgtatgggg
     4321 aacgcttatc attatgggcg tactgatagg atgtgctgtc ctcctgtggg caatcttttt
     4381 taatggataa ttatccattt aataaatccg tctttctgta attgggaaag ataggtagat
     4441 acacgagact cgtagcctgc ttcatattga aagtggtctg cgagtttttc tataatctca
     4501 cgaaccgtcc gctgcccgtc tatcaggttc catacagccg taccgtgttc ttccagacgc
     4561 acatgaatat ctttggacat tcctttcggc aataaataac gactcatcca cgaacgttta
     4621 aaacgaggga aggagagcac aatagtctcc ccttcctgtt cagctttaat atgttcgtta
     4681 cgacaaggga tcacctccag gaggtttatt ttctctttcg ttgccatatc ttttctcttt
     4741 tatatctttt cagatagaat atatactgtg attatttctg aatatttgct tcttccagtc
     4801 cgtagccttt cttcttgttt tctgctttca gcatcaaggc aacaatcagg gcaagtacac
     4861 cgaacatagc aaaaatagcc atcggcaagg tataatcata agtctgtgca ccatctacaa
     4921 ccggaccttt gcaataagaa ttcaacaccc atccaatcag caaaggcacg cccatcaatc
     4981 cccagttctg tacccaaaag atcaacgcat aagccgttcc caactgtttc tccggaataa
     5041 tcttcggaac cgaaggccac attgccgaag gaaccaatga gaaagcaaat cccagaataa
     5101 tcatgatcac cgttgcaaac caccagatat tcagaatagg aagagcgaac atagtgtgta
     5161 cgaaaatcag catcaccgac ccgatcacca tcagcgtggc tcccttaccg atacggtcat
     5221 acaatgaccc gaacaacggt gtcaggatga tcgcgccaat cggcagcaat ccgggaatcg
     5281 ttcccgcaag tttcggatct acattgtact tctgtaccat caaatcagcc gcatacttga
     5341 tgaaggggaa tacagccgaa tagaacaata cgcacagtaa tgcgatcagc cagaatcctt
     5401 tgttggtaat gatatatacg atgtctttca tgcggaaagg ttcttccggt tccagtcctt
     5461 ccgcatccag tgaagcatcc agtttcttat catagaaagt atagatgaag aatgcgatgg
     5521 tacctacgca cagcatgacg agacagaaca gaatcggagc gggaatattg gtatggaata
     5581 cgccgctctc atccgtagac ccgaagaagt ctgccaaagg aacggtaagc accatggcca
     5641 aagttgttcc aatacgcgcg gtcgccattt ccagtcccat agcgagagcc atctctttgc
     5701 ctttaaacca cttcacgata atcttcgaaa cggtgatacc cgcaatttcg actcctacac
     5761 cgaaaatagc atagcccaat gcagccaatg tgacttgcat cttgaatccg aaaagcatcg
     5821 caccttccgg gaaagtagta gtaatagcat aatatttcaa tccacaacca aacaccatca
     5881 ataaacaggc acccattccg gtgaagcgta ctcccatctt atccagaatg ataccaccaa
     5941 agatgagcat cagcaggaat acattaaacc agccataagc actggtgaaa aaaccgtaat
     6001 ctaaactgtc ccagagaagt tctttttcaa gcatgggttt cagaggagac ataacgtctg
     6061 tgaggaagta gccgcacaac atggtaaaag cgactaatgc tagaacactc caacgcagca
     6121 ctgcggagtc attcagcttt tgtttcaatt gttctgtcat tgtaatattt aaaaggagtt
     6181 aataatctcg taacgggcaa caaagttaac taattatcat ttgttttact aaaaaaggag
     6241 aacattttat aagaaaaagg acatctgacc ggatattcct gtatgaagaa gagcagaccg
     6301 gacccaataa taaagatagg cgcgaaccac acgtattaca caattctatt agaatctctt
     6361 gtaattcgcg taattcgcgc ctataatgaa gagaacgggt caaaaagccc gttcactcaa
     6421 taagtttaaa ccgaatatcc tgtcactgaa ttattctgct gcaggagcag gagtttcagt
     6481 agccggagct tctgttgctg gtgcagactc tgcaggagca gtagcgtctg tctgaggagc
     6541 agcagtaccg gtaggcatat tatacggatt ggtttgttgt tctttctgtg cttgttccaa
     6601 caatacatct ttagctgcag aagaagaagg aacaacgtaa gcagtagcaa cgctcatcac
     6661 aaccatgaag atagccagac cccaagttgc tttttccaga aaatctgtag tcttgcgcac
     6721 gcccatgata gcgtttgatg aagaaaaacc agaagcaagt ccgcctcctt ttgaattctg
     6781 aatcagcacg atgaagcaca tcagcaaggc tgcaatcacc attaagataa tgaataataa
     6841 gtacattttt agttattttg aattagcgtt aataatcaat ttctccaaaa atctgatttg
     6901 gtctgcaaag taagcatttt tttttggata tttcaagctt aattttttaa ttatttcaag
     6961 agcttttgaa tatcgttgct gtttaacata gatttttgcc aaagtttccg taaaacagct
     7021 gtcatcttcc tcttcttcct ttatcgtttc ttcttcggta agttcgtccg aagaggttgg
     7081 cgaagatggc atttcttctc ttaaaggttt catgcagagg ggagagtcgc tctcgctctt
     7141 ttctataaaa tcgtcaatca gttcgaagcc tttgagtttg ggcgtttctt cagccggctg
     7201 ttccgtggcc ggagtctcct ccaaaaggaa agaggtgtaa tccatcgaat agtcgaaact
     7261 ggtccgggca gtcacctctt cgggtactgt ggacaagaaa gcgtcgatca atgctaatgt
     7321 gcggtctacg gacggttcgt ctttcagcac ctccgtgaga ggtactccct ttttccgcgc
     7381 ctgcacatca tagcggtcac cttcaatcaa ccggaacaac tgccgtctgt ctgcaatgta
     7441 aagaactgct ttccgcagtt ctccaccgaa actaatatca tggagaatat acagattctt
     7501 cagatacaac agacgaagtg actgaaaata cggatacctc gcaagaagat tgcgcagttc
     7561 gtacaaagta tccctattca gcgtctcggg atgctgaatc cattgttgca agttaacaga
     7621 agtcattaaa ttaccagttt gctacagttg cattaaatat ttggtcggtt atctctttac
     7681 tcatttccgc tattaatcca tcctgtacgg ctgtcagcag ctggctggaa tcataggtac
     7741 gaaaagctga gaattgttgt tcgaagtctt cggcgtgatt tgtgttgttg acaaagcgta
     7801 cattgaccgt gatggtcagc ttcgtttccg aagagtaacc atcggcagac actgcctggt
     7861 tatactggtt gtagcccgta atttcaccgt caatctgcag atccgcattc tggttcggtt
     7921 ttagcagttg cagacgggtc tgtctgatga agatatcttt caggtcttca ttgaacttgg
     7981 tagccagcgg agcatacaca tactccgact taatcgggaa atcagcaatc gaaatggtct
     8041 tcaccttatc gtaattgata gaggagccat taaacttata ggacacacta caggcgatga
     8101 tgactgccgg taaaacaacc aatatcagcg gtcgtgctat tttcttaatc caattcatat
     8161 tcttttattt ttctgtaaag ggtacgctcg gagatattca gatccttcgc cgcacttttc
     8221 cgcttaccat gatgcctctc aagcgcttta cgtatcattt ctttttccac ttcatcgagc
     8281 gaaagggttt cttccacata ctcttccgtg tcctgaatat cgtcatcgtc ttctttggga
     8341 caaacagacg gttgctgcac agcatggatt atggccggca cggaaggttg gtgcgtcgtt
     8401 gtcactaccg gagtagctac tacctgtccc atctgtccga cttgtcccgc acgttcggcc
     8461 atcatattgt gcaccatctt cttcagttcc gccacttcct gacgcatatc gaacaagaca
     8521 gaatatagta tttcgcgttc gctctcaaag ctcttgctct cgcgtgtgcc gaacagtgcc
     8581 ggaaggcgtt gggtattctg tgccggaaga taggtctgca gaatcgcagc cgttatctca
     8641 cggtttgttt ctataatcga aatctgctct gtgatgttct tcaactgccg gacgtttccc
     8701 ggccacggat aagcaagcaa tatcttcttg gcatcttccg tcagctggat agccggcatc
     8761 cggtactttt cggcaaagtc tgcggcaaac ttacggaaca acaacagcac atcatctcca
     8821 cgctcacgca aaggtggtat ctgaataggc accgtgttca accgataata caaatcttcc
     8881 cggaagcgtc cttcggcaat ggcttgtgtc aggttcacgt tggtagctgc cacaatacgt
     8941 acatccgtct tttgcacttt ggatgaacct accttgataa attcaccgct ttcaagtaca
     9001 cggagcagac gcgcctgtgt aggcaacggc aactctccca cttcatcaag gaagatggtt
     9061 ccaccgtcag cttctccaaa atatcctttc cgctcaccaa tagcaccggt aaatgctcct
     9121 ttctcgtgtc cgaacagttc ggaatcgatc gtaccttccg gtatggcacc acagttgaca
     9181 gcaatatact gcccatgctt tctccggcta tattgatgaa tgatctgtgg aaaactttct
     9241 tttccgacac cactttctcc ggtaatcagc acagacaaat cggtaggcgc tacctgaatg
     9301 gcaacatcta tggcacgtga taaggcctcg gtattgccaa taataccgaa acgctgtttc
     9361 acttgttgta tctctgcttt ggtcatctat cttaatatta agtaataggt aataagtatt
     9421 aagtaataag tattaagtat taccatcact atcatctcgc ttctatccgc atggctaata
     9481 cttaatactt attacttaat acctattact taatcttcgt ctactgtatc cagttttagt
     9541 ttatcactat cgtcccgttt ctcgtaatac tgcttccgca acgggtttac ccgtgctgct
     9601 ttctcgcgct ggcggttgcg gaatacatca attgctacat aaatagcctg gcggaaagag
     9661 tcttcgctgg ccagtccttt accggcgatg tcataggctg ttccatgagc cggagaggta
     9721 cgtacaaccg gcagtccggc ggtatagttc acaccgtctt ccatagccag ggctttgaac
     9781 ggagccagtc cctgatcatg atacatagca aggattccgt caaagtgggt ataattgccc
     9841 gaacccataa aaccgtccgc agcataagga ccgtaacaga tgatcccttt ctcttccatt
     9901 tctttcatgg cagggataat gatttcctgt tcttccatac ccagcagtcc gccgtctcct
     9961 gcatgaggat tcagtgaaag cactgcaata cggggcgcac cgataccgaa atcctgtttc
    10021 aggcaacgat ggaaaatcat cagcttttcc tgaatcagtt ccttggtgat cgttgtggca
    10081 atctccctta ccggaatatg cgtcgttact aaagccacac gaaaatcgtt tttcatcagg
    10141 atcatcagtg acttgtttcc atcgcccaga cgttcttcaa tatactccgt atgaccgggg
    10201 aaagagaact cttccgactg aatggtatgt ttgttgatcg gagctgtcac aatgacgtcg
    10261 atcagcccct cacgatactc ttctatggca cgttctaaag cacccaatgc agccttacct
    10321 gcttcgggat cgggtttgga gaattccact ttcacttcgt catccgtaca gttcactaca
    10381 ctcagacggt tgtatccggc ttcggaagct gtgttgacaa tgctgaaatt agcctgtaca
    10441 tccagtgctt tacgatggta agccgctact ttaggtgaac cgtagataat cggagtacat
    10501 agctcaagca tggtagggtc tgagaatgtc ttcaagatca cttcataacc taccccgttg
    10561 atatctcctt gggtaatgcc gattcttatt ttgttttctt ccatgttttt atttattagt
    10621 tggttccgct tctttggtta cccccagtgg aatctggctc tgctgacctt cttgcggaag
    10681 tttcagcgta taaagagatg cttccatctg gcgaaccaga ttgcgtttca ttttatcggg
    10741 tgaatataca aatatttctg ctgtaataat acgttggttc ttctgatcca gacgagtatg
    10801 ggaaacgaac ggcccaccca tgaagtcacc cttcatgcgc cacaatccac gagcttccat
    10861 cgtgtagtca ttgtgcacgt tgatcggacg aacatcggtc agtaacgagt ctgtcgacat
    10921 atatacgcct tctttatatc cggggatatt ggctttcatc acggaatcgc gcttatgaac
    10981 aaagtattct ttggtgaatg tatccttgtc agtataagga taagaataca tcacgaaatt
    11041 gcgatccgcg ctgcctgtat tggtagatgc ccagaagaag tcctctcctg tcttggagtt
    11101 attcagttcg gaaggtatcc agatatcgca gccaaacaga ctatctacct tatttgagat
    11161 aaagttgttg tgcttttcct ccagcaaagt aatctgacgg ttcatttcag cgcgagtgaa
    11221 gaagtcgata atcgtctgct tattttcttc cacaaacttc tcaaacactt cttcgttcgg
    11281 agcctgaatg gtcagtatca tctgtggaga agcataaacg tctttcgcat acttgaaagt
    11341 acctttggta taaatatctt ttatatctac tatcacaata ttacggatca acttcagcgt
    11401 agaatcatag tccttcggtg aagtatacat aatccggaaa gaaggttccg actggggcag
    11461 tcccggcatg tcagaatcaa gcacatcatg caaggccctt ccggcggcac ggtcccacac
    11521 tcccgcatct actacaacca acagttcata cggacgaccg ctagaggtat gattcccctt
    11581 taatccacaa gaagcaacta cgaaggctac cagagccatg cttaaataaa aaaagtactt
    11641 tttcatgatg ttcgattttt atattaactt ttattatttt cctcctgttt cgcagtcgac
    11701 agcataccgc atgccgcaaa aatatcctct ccccgcgaag cacgaatggt agtgaaaagc
    11761 ccgtgcgtgg tcagatagtc acggaaacgg gtcatcgtat ccatatcggc tccttcaagg
    11821 gctactcccg gaatagaatg gaaacggatc aggttaatcc ggcaatccag tccgcgaagc
    11881 agtttgagta actccttggc ataaacttgc gaatcattaa gccccttaaa aacaatatac
    11941 tcaaacgaaa gtcgacgctg tttgctaaaa tcatagtttt ttaacagttc caccatttcc
    12001 gtgatagaaa aggctttctc cgccggcatc agttccgcac gctgggcggt caccggagaa
    12061 tgcaggctga tggcaagatg acagtcgctt tcttcgataa agcgccgcaa tcctttccgc
    12121 aatccgacag ttgaaacggt aatccgcttc ggactccatg cataaccata ggatccagtc
    12181 agtatgtcca atgccttcaa cacctcttcc agattatcga gcggttcgcc cattcccatc
    12241 atgacgacat tcgtcagttt gtcccgttcc ggcaaggagt gaatctgatt gataatctga
    12301 tgggcggtca ggttggcaga gtagccttgt ttcccggtca tacagaactt gcagttcatt
    12361 ttgcagccta cctgcgaaga gatgcataaa gtcgcccgtt catcatccgg aatatacacc
    12421 gactccacaa aatgattctc gcccacaggg tacaggtatt tcaccgtacc gtctacagag
    12481 cgcatttcct ccaccggagc ttcagctcct acctcatagt tctgcttcag taactcccgg
    12541 tatttcaacg acaagttagt catttcatca atcgaagtca ccttcttatc ataaagccag
    12601 gatgcaatct gtttggctgc aaagcccggc attcccagac gtttcaccag tgactgcagc
    12661 tctataagcg tcattcctaa gaggggatat ttagacatca ttctttctgt tcatggttta
    12721 tatttgcaaa tgtaaggaaa taaagtcgat ttccgtatag caaggatgta aaagttagca
    12781 aaaaaggtcg ttccaaagca tggaacgacc ttttgcagtt atcgatttta cgactaatct
    12841 tagaagaaca ggtaacgtgt atccttcact tttcctttca gatacaggtc gttcatcaga
    12901 cggcttgcga agcgtgcgtg catgttagcc aatgtagctt cttcatcttt agcgttgaaa
    12961 gtatcgctca gtttgtcttt gccatacatc tgaagcacaa atacaccggc attacctttg
    13021 atcggagcgc tcagtttgtt catttcagcc acagaagcat aagcacctac caacggttcg
    13081 ctgctgcgca atgcagaaac ataagcggga gcggcaaatg taaccagctt caaagaatcg
    13141 ctgactgcgc cggacatagc cttgtactgg tcgagagaag ttgcattggc agccttcatg
    13201 tcagccatga tcttttcggc tttcttatct ttaacgattt cagctctcaa ctgatcctgt
    13261 acagctttta gcggacgata tccttccgga gtaacaccaa ccagagctac tgcaaccata
    13321 tggtcgcttt cgccacattc atacaaaccg gaaacatcac ccggtttagc ggcaaatgcc
    13381 catctcaatg cttctttagt acctcttaca ccaccgatag tgtgttctga gctatacaag
    13441 tctcttctgt caagcagttt gtatccggct tcttcagcgt tagcgatcat cttttcagca
    13501 gtaggattgg cagcgatgaa ctggctgaaa tcattgtaag cacgattata agtctctttg
    13561 ctgaattcaa cttcacgttt cacaacagct actttatatt tatccttcac agctttcttg
    13621 ttagtcactt gcaggattac attagcttgt cccaacggca gatttactac ttcgttcacg
    13681 cctgtattat tgatagcaga gataaacttc aggttgtcac catcgatctg tgcgccttca
    13741 tactgtgcag agctcatcca gttagtctca cccgtctgac cgtatttctt agccagatct
    13801 gcgaagttag caccgccttt gatagcagta tagatactgt ccgccaaggc ttttgtcttc
    13861 aaagcgtctt ctgcaaacac ctgaatctga cggaactcga ttgagtcggc agcagctgtt
    13921 tttgcaacca ctttgaatga attgatagta ttgtcggcac cattatagta cggaccataa
    13981 acagaaccaa cggatgcaga gtccagacgg gcaactacat ctgacgggaa agctgtttta
    14041 ttatagaaca agtctacata aggagcttcc gagcctacag aacggataaa agaagtatag
    14101 tcatctgttg tagtagccag ctgtgcagta gcttcgtcta cttcctgctg gatagcagct
    14161 ctgtcttccg cacttgcagt cacctgaaca tcaatgtact tgatatcacg gctttcctga
    14221 tattgcttga actgttcttt tttcttgtta taaaggtctt tcagttccga ttctttcaca
    14281 acgattgtag aatctactat agaagaataa ggaacggcag ccatcaacaa atcatattga
    14341 ttcactcttg cgtcgaaagc gtcctgtgct tctaccgggt tagagagaag cgcttttgct
    14401 actaatgcct gatatttttc tgccaggcgg ctctgaatca atgtcttctg gatgaatgac
    14461 cagtatttgt acatgttgtt gtactgttct gcatactgag ccggcatctg agattcgttc
    14521 attttagcgt aatctaccag gaacttattg agcatatcct tatcgaaagc accggtctgc
    14581 gggttgcgga aaggagtctg ttgcaacaac ggatgcacgc ctgctttcag gatatcctga
    14641 atttcagcag cagaaactgt cagtcccaat gcttttgctt ctttctcaac cagtttgtta
    14701 ttaacgtagg aacgccatac ttcgtcg
//
