LOCUS       c00160_gnlPro..        15133 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ALHIGKOD_160.
ACCESSION   c00160_gnlPro..
VERSION     c00160_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 17:14:05
            Original ID  :: gnl|Prokka|ALHIGKOD_160
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15133
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15133
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:5133]"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..5133
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
     cand_cluster    1..15133
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /kind="single"
                     /product="Rnf_complex"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15133
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Rnf_complex"
                     /region_number="1"
                     /rules="(Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4,
                     Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))"
                     /tool="gutsmash"
     CDS             3..866
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FeS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_17"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1016:4Fe-4S dicluster domain (Score: 38.7; E-value:
                     3.9e-12)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg160_1"
                     /sec_met_domain="Fer4_7 (E-value: 1.1e-12, bitscore: 38.7,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 3.6e-09, bitscore: 26.5,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_2 (E-value: 7.4e-09, bitscore: 25.7,
                     seeds: 214, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 3.5e-09, bitscore: 26.8,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_17 (E-value: 1.2e-08, bitscore: 25.6,
                     seeds: 82, tool: rule-based-clusters)"
                     /sec_met_domain="FeS (E-value: 3.1e-11, bitscore: 33.1,
                     seeds: 364, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.1e-06, bitscore: 17.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="AVISLGAIALVLAAILYVASKKFAVYEDPRIAQVGEVLPQANCGG
                     CGYPGCSGFADACVKAGSLDGKFCPVGGQPVMAQIADILGLAATEAEPMVAVVRCNGSC
                     ANRPRINQYDGAKSCAIAASLYGGETGCSYGCLGCGDCVAACQFDAIHMNPETGLPEVD
                     EAKCTACGACVKACPKAIIEIRPQGKKSRRVYISCVNKDKGAVARKACTVSCIGCGKCV
                     KTCPFEAITLENNLAYIDPNKCKSCRKCVEVCPQNTIIELNFPPRKPKAEEAPKTVAAE
                     APKVTE"
     CDS             891..2228
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: RnfC_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Complex1_51K"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: SLBB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_10"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg160_2"
                     /sec_met_domain="Fer4_10 (E-value: 1.7e-09, bitscore: 28.0,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="SLBB (E-value: 9.9e-17, bitscore: 50.9,
                     seeds: 67, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_51K (E-value: 3.5e-51, bitscore:
                     163.3, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="RnfC_N (E-value: 2.2e-30, bitscore: 94.9,
                     seeds: 53, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.4e-06, bitscore: 17.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKTFSIGGVHPHENKLSAHQPIITAEVPAKAVILLGQHIGAPAK
                     PIVAKGDMVKVGTKIAEPAGFVSAAIHSSVSGKVAKIDTVVDASGYAKPAIFIDVEGDE
                     WEEAIDRSKTLVKECELSSEEIVKKIADAGIVGLGGACFPTQVKLCPPPSFKAECVIIN
                     AVECEPYLTADHQLMLEHAEEVMVGVSILMKAVKVNKAFIGIENNKPDAIELMTKVASS
                     YAGIEVVPLKVKYPQGGEKQLIDAITKRQVASGALPISTGAVVQNVGTAFAVYEAVQKN
                     KPLFERVITVTGKSVAKPSNFLARIGTPMKQLIDACGGLPEDTGKVIGGGPMMGKALVN
                     IEVPTAKGSSGILIMNQKEAKRGEAQTCIRCAKCVSACPMGLEPYLLGALSENGDFETM
                     EKERIMDCIECGSCQFTCPANRPLLDYCRLGKGKVGAMIRARQAKK"
     CDS             2234..3226
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: NQR2_RnfD_RnfE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg160_3"
                     /sec_met_domain="NQR2_RnfD_RnfE (E-value: 2e-120, bitscore:
                     391.7, seeds: 472, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKLIVSLSPHVHGGDSVQKNMYGVLIALIPAFLVSLYFFGLGA
                     LIVTATSVAACLFFEWAIGKYLMKKPTTTICDGSAIITGVLLAFNLPSNLPIWIIILGA
                     LFAIGVGKMSFGGLGCNPFNPALAGRVFLLLSFPVQMTSWPVVGQLTAYTDATTGATPL
                     ALMKQAIYGDTAALSQIPDALTLLIGQNGGCLGEVSALALLIGLVYMLWKKIITWHIPV
                     SILATVFVFAGIMHLADPEKYVSPVLQLLSGGLMLGAVFMATDYVTSPMSKKGMLIYGV
                     CIGLLTVVIRLFGAYPEGMSFAILIMNAFTPLINTYCKPKRFGEVAKKK"
     CDS             3253..3936
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FMN_bind"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg160_4"
                     /sec_met_domain="FMN_bind (E-value: 1.2e-23, bitscore:
                     73.8, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLVLTGVTAVSVALLAYVNELTKGPIAEANAKTLNEALKKVLPE
                     YTNNPVAESDTVFSEKDGKKIVDFIIYPAKNGEKWVGSAVEAKSMGFGGELKVLVGFDA
                     EGKIYNYSLLAHAETPGLGSKADKWFGAYDPAKNEKPVSHEESAKSILGMNPGETPLAV
                     TKDMNGQVDAITASTITSRAFLNAVNAAYQAYKGGEVDTNSGASQKNEPAVAPEGEAAA
                     NDTNN"
     CDS             3972..4538
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg160_5"
                     /sec_met_domain="Rnf-Nqr (E-value: 1.5e-70, bitscore:
                     226.9, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNGIIKENPIFVLLLGMCPTLGTTSSAINGMGMGLATMFVLICS
                     NVVISSIKNLIPDMVRIPSFIVVIASFVTLLQMIMQAYVPDLYATLGLFIPLIVVNCIV
                     LGRAEAFAAKNNPLASMFDGIGMGFGFTIALTLLGAVREFLGTGKIFNLTILPEEYGML
                     IFVLAPGAFIALGYLIAIINSLKKA"
     CDS             4561..5133
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg160_6"
                     /sec_met_domain="Rnf-Nqr (E-value: 3.2e-63, bitscore:
                     203.0, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYILIFISAIFVNNIVLSQFLGICPFLGVSKKVETAMGMSAAVA
                     FVLTIATIVTFLIQKFVLDAFGLGYLQTITFILVIAGLVQMVEIILKKVSPSLYQALGV
                     FLPLITTNCCILGVAILVIQKDFDLLTGVVYAFSTALGFGLALVLFAGLREQMTLVKIP
                     KGMQGTPIALITAGLLAMAFMGFSGVV"
     CDS             5392..6426
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg160_7"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 6.3e-53, bitscore:
                     170.4, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKERILVTGGTGYIGSHTVVELQNSGYEVIIIDNLSNSSADVVDN
                     IEKVSGIRPAFEKLDCLDFAGLDAVFAKYKGIKAIIHFAASKAVGESVEKPLLYYRNNL
                     VSLINLLELMPKHGVEGIVFSSSCTVYGQPDELPVTEKAPIKKAESPYGNTKQINEEII
                     RDTIASGAPINAILLRYFNPIGAHPTALLGELPNGVPQNLIPYLTQTAMGIREKLSVFG
                     DDYDTPDGSCIRDFINVVDLAKAHVIAIRRILEQKQKEKVEVFNIGTGRGVSVLELING
                     FEKATGVKLNYQIVGRRAGDIEKVWANPDYANQELGWKAVETLEDTLRSAWNWQLKLRE
                     RGIQ"
     CDS             complement(6659..7483)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg160_8"
                     /sec_met_domain="GHMP_kinases_C (E-value: 1.7e-10,
                     bitscore: 31.4, seeds: 112, tool: rule-based-clusters)"
                     /sec_met_domain="GHMP_kinases_N (E-value: 2.3e-10,
                     bitscore: 30.9, seeds: 447, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITFPNAKINLGLSITEKRPDGYHNLETVFYPVALEDALEIRTSP
                     EADKKFSLHQYGMEISGNPEDNLVVKAYLLLDKEFHLCPIEIHLYKHIPSGAGLGGGSS
                     DAAFMLKLLNEHFQLNLSEDQLEIYAATLGADCAFFIKNAPTFAEGIGNIFSPIPLSLK
                     GYKILIIKPDVFVSTREAFANIHPHHPEYSIKEAIKRPVNEWKEILINDFEDSVFPQHP
                     VIGEIKAELYRQGAVYASMSGSGSSVYGLFEPEGTLPETDWGTNVFCFKGRL"
     CDS             7682..9235
                     /locus_tag="ctg160_9"
                     /transl_table=11
                     /translation="MAEQRRNSRNTKSTKVQPVNDYGRIQPQAPELEEAVLGALMIEKD
                     AYSLVSEILRPESFYEHRHQLIYAAITDLAVNQKPVDILTVKEQLSKRGELEEVGGPFY
                     ITQLSSKVASSAHIEYHARIIAQKSLARELITFTSNIQSKAFDETLDVDDLMQEAEGKL
                     FEISQQNMKKDYTQINPVIDEAYKLIQKAAARTDGLSGLESGFTKLDKMTSGWQNSDLI
                     IIAARPAMGKTAFVLSMAKNIAVDYRNPVALFSLEMSNVQLVNRLITNVCEIPSEKIKS
                     GQLASYEWQQLDYKLKDLLDAPLYVDDTPSLSVFELRTKARRLVREHGVRIIIIDYLQL
                     MNASGMAFGSRQEEVSTISRSLKGLAKELNIPIIALSQLNRGVESREGIDGKRPQLSDL
                     RESGAIEQDADMVCFIHRPEYYKIYQDDRGNDLRGMAEIVIAKHRNGAVGEVLLRFKGE
                     FTRFSNPEDDMVIPMPGEPAGAMLGSKLNAGAMPPPPPEPDFVPQGNNPFGATEGPLPF
                     "
     CDS             complement(9232..9417)
                     /locus_tag="ctg160_10"
                     /transl_table=11
                     /translation="MVGDKVAKNKGVFFVIFATYPYQNTTWLYSIKNNRPLDWSKSSGY
                     FHLTKRSFYSTQKMFF"
     CDS             9557..12019
                     /locus_tag="ctg160_11"
                     /transl_table=11
                     /translation="MNISYNWLKEYVNFDLTPDETAAALTSIGLETGGVEEVQTIKGGL
                     EGLVIGEVLTCEEHPNSDHLHITTVNLGDGEPVQIVCGAPNVAAGQKVVVATLGTKLYD
                     GDECFTIKKSKIRGVESTGMICAEDEIGIGTDHAGIIVLPAEAVPGTLAKDYYNIKSDY
                     VLEVDITPNRADACSHYGVARDLYAYLIQNGKQATLQRPSVDGFKVENHDLDIEVVVEN
                     SEACPHYAGVTVKGVTVKESPEWLQNKLRLIGVRPINNVVDITNYIVHAFGQPLHCFDA
                     GKIKGNEVIVKTLPEGTPFVTLDEVERKLNERDLMICNKEEAMCIAGVFGGLDSGSTEA
                     TTDVFIESAYFHPTWVRKTARRHGLNTDASFRFERGIDPNGVIYCLKLAALMVKELAGG
                     TISSEIKDVCVAAPQDFMVELSYEKVNSLIGKVIPVETIKSIVTSLEMKIMNETVDGLT
                     LAVPPYRVDVQRDCDVIEDILRIYGYNNVEIPTTLNSSLTTKGEHDKSNKLQNLVAEQL
                     VGCGFNEILNNSLTRAAYYDGLENYPSNHLVMLLNPLSADLNCMRQTLLFGGLESIAHN
                     ANRKNADLKFFEFGNCYYFDADKKNPEKVLATYSEDYHLGLWVTGKKVANSWAHPDENS
                     SVYELKAYVENILKRLGLDLHNLVVGNLTDDIFATALSVHTKGGKRLASFGVVTKKLLK
                     AFDIDNEVYYADLNWKELMKAIRSVKISYKEISKFPAVKRDLALLLDKNVQFAEIEKIA
                     YDTEKKLLKEVELFDVYEGKNIEAGKKSYAVSFLLQDETQTLNDKMIDKIMSKLVKNLE
                     DKLNAKLR"
     CDS             12055..12798
                     /locus_tag="ctg160_12"
                     /transl_table=11
                     /translation="MGRAFEYRKAAKLKRWGHMAKTFTRLGKQIAIAVKAGGPEPENNP
                     TLRSVIATCKRENMPKDNIERAIKNAMGKDQSDYKSMTYEGYGPHGIAVFVDTLTDNTT
                     RTVADVRSVFNKFGGNLGTMGSLAFLFDHKCMFTFKIKDGMDMEELILDLIDYDVEDEY
                     EQDDEEGTITIYGDPKSYAAIQKHLEECGFEDVGGDFTYIPNDLKEVTPEQRETLDKMI
                     ERLEEFDDVQTVYTNMKPEEGGNEE"
     CDS             12806..13051
                     /locus_tag="ctg160_13"
                     /transl_table=11
                     /translation="MEYVYRTQGTCSTNIELNVEDGVVKEVAFWGGCNGNLQGLSRLVK
                     GMKVEEVIKKLEGVRCSGRPTSCPDQLCHALHEMGY"
     CDS             13213..14469
                     /locus_tag="ctg160_14"
                     /transl_table=11
                     /translation="MMKNIFQDLKRKDHKRYLGGLDVFKYIGPGLLVTVGFIDPGNWAS
                     NFAAGSEFGYSLLWVVTLSTIMLIVLQHNVAHLGIVTGLCLSEAATKYTPKWVSRPILG
                     TAVLASISTSLAEILGGAIALEMLFDMPIMWGAVLTTLFVSIMLFTNSYKKIERSIIAF
                     VSVIGLSFIYELFLVEIDWPAATMGWVTPAFPKGSMLIIMSVLGAVVMPHNLFLHSEVI
                     QSHEYNKKDDASIKKVLKYELFDTLFSMIVGWAINSAMILLAAATFFKSGIQVEELQQA
                     KSLLEPLLGSNAAIVFALALLMAGISSTITSGMAAGSIFAGIFGESYHIKDSHSQVGVI
                     LSLGIALLLIFFIGDPFKGLLISQMILSIQLPFTVFLQVGLTSSRKVMGNYVNSRWSTF
                     VLYAIAVIVSVLNIMLLFS"
ORIGIN
        1 ttgcagtgat ttcattggga gctatagcgc tcgtgctggc cgctattctt tatgtagctt
       61 ccaagaaatt tgccgtgtat gaagacccgc ggattgccca ggtaggggaa gtgttgcccc
      121 aggcaaactg tggtggatgt ggctatcctg gttgtagcgg atttgccgat gcttgcgtca
      181 aagccggttc gctggatggt aaattctgcc ctgtaggcgg tcagcctgtc atggcacaaa
      241 ttgctgatat tctcggactg gcagctactg aagctgaacc gatggtagca gtagtaagat
      301 gtaacggaag ctgtgccaat cgtccgcgta ttaatcaata cgacggtgcg aagagttgcg
      361 ctattgccgc ttcattgtat ggtggagaaa caggttgtag ctacggatgc ctcggatgtg
      421 gcgactgtgt ggctgcctgc cagttcgacg ctatccacat gaatcccgaa acgggacttc
      481 cggaagtgga tgaagccaaa tgtacagctt gtggcgcttg tgtgaaggct tgtccgaagg
      541 cgatcatcga gattcgtccg caaggcaaga aatcacgccg tgtgtacatc tcttgtgtga
      601 acaaagacaa gggagccgta gcacgtaagg cttgtacagt gagctgtatc ggctgtggta
      661 agtgtgtcaa gacttgtccg ttcgaagcca ttacgctgga gaacaacctg gcttacatcg
      721 atccgaacaa gtgtaaatca tgccgtaagt gcgtggaagt ttgtccgcag aacacgatta
      781 tcgagctgaa cttccctcca cgtaaaccga aggcggaaga agcaccgaaa acagttgctg
      841 cagaagctcc gaaggtaaca gaataataac agaataaaat acagaattgt atgttaaaga
      901 cattttcaat tggtggagtt catccacacg aaaataaatt gtcggcacat caacctatca
      961 tcacagcgga agttcctgca aaggcagtta ttctgttggg gcagcacatt ggcgcacctg
     1021 ccaaaccgat agtagcaaaa ggtgatatgg tgaaggtagg cacgaagatt gccgaacctg
     1081 ccggcttcgt ttcggcagca attcactctt ctgtcagtgg aaaagtggcg aagattgata
     1141 cagtagtcga tgcgagcggt tatgcaaaac ctgctatctt tattgatgta gaaggcgacg
     1201 aatgggaaga agccattgac cgtagcaaga cactggtcaa agaatgtgag ctttcgtccg
     1261 aagaaatcgt gaagaagatt gccgatgccg gtatcgtagg tttgggtggt gcttgtttcc
     1321 ctacacaggt gaaactttgt ccgcctcctt cgttcaaggc agaatgtgtg attatcaatg
     1381 cggtggaatg tgaaccgtat ctgactgccg accatcagct gatgctggaa cacgcggaag
     1441 aagtcatggt aggtgtctcc attctgatga aagccgtgaa ggtaaataag gcatttatcg
     1501 gaattgagaa taacaagccg gatgctattg aactgatgac gaaagttgct tccagttatg
     1561 caggcatcga agttgttcct ttgaaagtga aatatccgca gggcggtgag aaacagttga
     1621 ttgatgcgat taccaaacgc caggtggcaa gtggtgcgct gcctatctct actggggcag
     1681 ttgtgcagaa tgtgggtacg gcatttgctg tttatgaagc tgttcagaaa aataaaccgt
     1741 tgtttgagcg tgtgattacc gtaactggta agtctgtggc caaaccttcc aacttcctgg
     1801 ctcgtatcgg tacaccaatg aaacagctga ttgatgcttg tggcggtctg ccggaggata
     1861 cgggaaaagt gatcggtggc ggtccgatga tgggtaaggc tctggtgaat atcgaagttc
     1921 ctaccgcaaa aggcagttcc ggcatcttga ttatgaatca gaaggaagcc aaacgtggtg
     1981 aagcacaaac ctgtatccgt tgcgcaaagt gtgtgagcgc ttgtccgatg ggattggagc
     2041 cgtacttgct cggagctttg tccgaaaacg gagattttga aacaatggaa aaagaaagaa
     2101 tcatggattg tatcgagtgc ggctcttgcc agttcacttg tcctgccaac cgtccgctgc
     2161 tcgactactg tcgtctgggc aaaggcaaag taggtgctat gattcgtgca cgtcaagcta
     2221 aaaaataacg aatatggaaa ataaattaat cgtatcacta tcaccccacg ttcatggcgg
     2281 agacagcgta cagaaaaata tgtatggcgt gctgatcgca ctgattccgg cttttctggt
     2341 gtctctctat ttcttcggac tgggtgccct gattgtcacg gctacttccg ttgcagcttg
     2401 tttgttcttc gaatgggcga tcgggaaata tttaatgaag aaacctacca ctaccatctg
     2461 cgacggctct gccatcatca caggtgtgtt gctggcattc aacttaccgt ctaatctccc
     2521 tatctggatt atcattctgg gtgcactgtt tgctatcggt gtaggcaaaa tgtctttcgg
     2581 cggattaggt tgcaatcctt ttaatccggc actggcagga cgtgtgttcc tgttgctttc
     2641 tttcccggtg cagatgacca gctggccggt agtcggacag ttgaccgctt atacggatgc
     2701 taccaccggt gccactccgc tggccttgat gaagcaagcc atttacggtg acactgccgc
     2761 tttaagccag attccggacg cattgacctt gttgatcgga cagaatggcg gatgcttggg
     2821 tgaagtgagt gcactggctc tgctgatcgg actcgtttat atgctctgga agaaaatcat
     2881 cacctggcat attcctgtgt ctatcctggc tactgtgttt gtctttgcag gcatcatgca
     2941 cctggcagat ccggaaaaat acgtttctcc ggtattgcag ttgctttccg gtggtctgat
     3001 gctgggtgct gtctttatgg caaccgacta tgtgacttct ccgatgagta agaaagggat
     3061 gctgatctat ggtgtatgta tcggtctgct gacggtagtt atccgtctgt tcggcgccta
     3121 tcccgaaggt atgtcgttcg ccatcctgat tatgaatgcg ttcactccgc tgattaacac
     3181 ctattgtaaa cctaaacgct ttggggaggt agcgaagaag aaatgaaaaa gttacaatca
     3241 tctttaaaga atatgttgct ggtacttacg ggcgttacag ctgtttccgt agcgttgctg
     3301 gcttatgtga acgaactgac gaaaggccct attgccgaag cgaatgcaaa gacgctgaac
     3361 gaggccttga aaaaggtgct tcctgaatat accaataatc cggtagccga aagcgatact
     3421 gttttcagcg agaaagacgg aaagaaaatc gtggatttca ttatctatcc ggccaagaat
     3481 ggcgaaaagt gggtaggttc tgccgttgaa gccaagtcaa tgggatttgg cggtgaactg
     3541 aaagtgctgg tgggctttga tgctgaaggc aagatttata actactcttt attggcgcac
     3601 gctgaaactc cgggattggg ttcgaaagcg gacaaatggt ttggagctta tgatcctgca
     3661 aagaacgaaa aaccggtatc tcacgaagaa agtgcaaagt ctattttggg catgaatccg
     3721 ggagagactc cattggctgt gaccaaagac atgaatggac aggtagatgc tatcacggct
     3781 tctactatca cttcacgtgc tttcctgaat gcggtgaatg ctgcttatca ggcatataaa
     3841 ggcggtgagg tggatacgaa ttccggagct tcccagaaaa atgaaccggc tgttgcgccg
     3901 gaaggtgaag cagctgctaa tgacactaat aactaagaaa ggaggagaca gttatgaata
     3961 attttaaagt aatgatgaac gggattatca aagagaatcc tatttttgtg ctcctgctcg
     4021 gtatgtgtcc tacactgggt acgacatcat cggcaatcaa cggtatgggt atgggactgg
     4081 ccactatgtt cgtcctgatt tgctcgaacg tggtaatttc atctatcaag aatctgattc
     4141 cggatatggt acgcatccct tcatttatcg tggtgatcgc gtcattcgtg acactgttgc
     4201 agatgataat gcaagcatac gtgcccgatc tgtatgctac cctcggtctt ttcattccgc
     4261 tgatcgtagt aaattgtatc gtattgggac gtgcggaagc tttcgcagcg aagaacaatc
     4321 cgctggcttc tatgtttgat ggtatcggta tgggatttgg ttttaccatt gccctgactc
     4381 tgttgggtgc cgtacgtgaa ttcctcggaa caggtaagat atttaatctg accattctgc
     4441 cggaagaata cggaatgctg atctttgttc tggctccggg tgcctttatc gctttaggtt
     4501 atctgattgc cattattaat agtctgaaga aagcctaact ctattaaata agaaaagaat
     4561 atggaatata tattgatatt tatctcggca atctttgtaa acaacattgt gttgtcgcag
     4621 ttcctgggaa tctgtccgtt cctgggtgtt tccaagaagg tggaaacagc gatgggtatg
     4681 agtgcggcag ttgctttcgt gctgactatc gctaccatcg tcacattcct gattcagaag
     4741 tttgtgttgg acgctttcgg attggggtac ttacagacaa tcacttttat tctggttatt
     4801 gccggactgg tgcagatggt agaaattatt ctgaagaaag tttctccttc tttgtatcag
     4861 gcactggggg tgttcctgcc gttgattaca acgaactgct gtattctcgg tgtggcaatc
     4921 ctggtaatcc agaaagactt tgatctgctg acaggtgttg tatacgcatt ctctactgct
     4981 cttggctttg gtctggcact ggtattgttt gccggattgc gtgagcagat gaccctggtg
     5041 aagattccga aaggaatgca ggggactccg attgctttga ttaccgcagg tttgctggca
     5101 atggcattca tgggcttctc tggcgtcgtg taaaagacta agttgataat tagataaaga
     5161 ggctggaaac tctgtcgtat ggcaacatac aggcagtttg tttccggcct ttttctttat
     5221 atctgttcat accgaatatg ttttttatca taccaaaacg ccctcaaatc gtcccgtaag
     5281 tatcttcctg tgaataaaat tgcgatagtt tattgcattt ccattttatt tccatacatt
     5341 tgtacctcaa acaaactgaa aaccgaaaaa ctaaccatat tttaaaatta tatgaaagaa
     5401 agaattttag taacgggagg aacaggctat attgggtctc ataccgttgt agaactacaa
     5461 aacagtggat acgaagtaat cattatcgat aatttatcaa attcgagtgc tgacgttgtt
     5521 gacaatatag agaaagtatc cggtatccgc ccagcttttg agaaactgga ttgtcttgat
     5581 tttgctggcc ttgatgccgt atttgccaaa tataaaggaa ttaaagcgat tattcatttc
     5641 gcagcaagca aagcagtagg agagtcggta gagaagccgt tgctttatta tcgtaacaac
     5701 ctggtttctt taatcaacct tctggagtta atgcctaaac atggagtaga aggcatagtg
     5761 ttctcttctt cctgtacagt atatggtcaa ccggatgagt tgcctgtaac ggaaaaggct
     5821 ccgatcaaga aagcggaatc tccttatgga aatacaaaac agattaatga agaaattatc
     5881 cgtgatacaa tagcttccgg tgccccgatc aatgctattt tgctgcgtta tttcaatccg
     5941 attggcgcac atcctacagc attgctgggt gaacttccga acggtgttcc tcaaaacctg
     6001 attccttatc tgactcagac agcgatgggt atccgtgaaa aactaagtgt attcggtgac
     6061 gattatgata ctcctgacgg ttcttgtatc cgtgacttta tcaacgttgt tgacttggct
     6121 aaagcacacg tgattgcaat ccgccgtatt ttggagcaaa aacagaaaga aaaagtagaa
     6181 gtattcaata tcggtacagg acgcggcgtt tcagtattgg aactgattaa tggctttgaa
     6241 aaagctaccg gcgttaaatt gaattatcag attgtaggcc gtcgcgcagg tgatattgaa
     6301 aaggtatggg ctaatcccga ttatgcaaac caggaactgg gttggaaagc ggtagaaaca
     6361 ttagaagata ctttacgctc tgcatggaat tggcagctga aactccgtga aagaggcatt
     6421 cagtaaaaag atatttgttt taattaacat aaaagtttaa acaaatcgtt catgcgattt
     6481 gtttattaga tgctaatcag cttgatctgt ttgtgagtat gtgaatatga gtaaatggta
     6541 cttatgcctc tccggcatag acaggtatga ttgcatagta gttttgtcgt gttttatttt
     6601 gtgtttgtgt tgtgacggta ctacgacggg agtcgtggta ccgttttttg ttactctttt
     6661 acagcctgcc tttaaaacag aatacgttag ttccccaatc ggtttcaggt aaagtccctt
     6721 ccggttcgaa caatccatat acggaagaac cggaaccgct catagaggca taaacagccc
     6781 cttgcctgta tagctcggct ttaatttctc cgatcaccgg atgctggggg aatacgctgt
     6841 cttcaaaatc attgattaat atctctttcc attcatttac cgggcgttta atcgcttctt
     6901 tgatcgagta ttcgggatga tgagggtgaa tattggcgaa agcttcccgc gttgatacga
     6961 atacatccgg tttgatgatc agaatcttat atccttttaa ggatagtgga atgggggaga
     7021 atatgttgcc gattccttcg gcaaaggtcg gggcgttttt gataaagaaa gcgcagtctg
     7081 ctcccaaagt tgcggcatat atttccagct gatcttcgga taaattcagc tgaaagtgtt
     7141 cgttgagtaa tttcagcatg aaagccgcgt ctgatgagcc tcctcccagt ccggcaccgg
     7201 aaggaatgtg tttgtacaga tggatctcga taggacagag gtgaaactct ttatctaata
     7261 gcagatatgc tttcaccact aaattgtctt ctggattacc ggatatctcc attccgtact
     7321 gatgcaggga gaactttttg tccgcttcgg ggctggtccg gatttccagc gcatcttcga
     7381 gagcgacggg gtagaatacg gtttcgaggt tgtgatatcc gtccggacgc ttctcggtaa
     7441 tagagagtcc caggtttatt tttgcgtttg ggaaagtgat catattcgtt ctgaattatt
     7501 atttttgaat tttaaattat gggttgcgaa tttatgctat tggtgacaaa gttactaaaa
     7561 tcttcatttt tccttatctt ttcttcatta ttatattcta tctttgtcat ccctttcggc
     7621 ttttactatg tataaaagcc ggggatcata aattgtaaat cataaaattg tatataagca
     7681 gatggctgaa caaagaagaa attcccgtaa cacaaaatca actaaagtac aaccggtcaa
     7741 tgattatggt cgtatccaac ctcaggcacc ggagctggaa gaggcggtgt tgggtgcttt
     7801 aatgattgag aaggatgctt attcgctggt gagtgagatt cttcgcccgg agtcatttta
     7861 tgagcatcgt catcagttga tttatgctgc cattactgat cttgccgtta atcagaagcc
     7921 ggtggacatt ctgacggtca aagagcagtt gagcaaaaga ggtgagttgg aagaggtcgg
     7981 tggaccgttc tatattactc agttgagcag taaggttgct tcttccgcac atatcgaata
     8041 tcacgcccgt attattgcac aaaaatcgtt ggcgcgcgaa ttgataacgt ttaccagtaa
     8101 tattcaaagc aaggcttttg atgagacact ggatgtggac gacttgatgc aggaggcgga
     8161 aggcaagctg tttgagattt cccagcagaa tatgaagaaa gactatacgc agattaatcc
     8221 ggtaattgac gaagcgtata agctgattca gaaagcggct gcacgaacgg acggtctgag
     8281 tggtcttgaa agtggattta cgaaactgga caagatgacc tccggttggc agaactccga
     8341 ccttattata atcgctgccc gtcctgccat gggtaagaca gctttcgtac tttctatggc
     8401 taagaatatt gctgttgatt atcggaatcc ggtagcgttg ttctctcttg aaatgagtaa
     8461 cgtccagttg gtcaaccgtc ttatcaccaa tgtttgtgag attccgagtg agaagatcaa
     8521 aagtggacaa ttggcaagct atgagtggca acagttggac tacaaactga aagatctgct
     8581 ggatgctccg ctttatgtgg acgatactcc gtctttgtct gtgtttgaac tccggaccaa
     8641 agcgcgtcgt ctggtgcgtg aacatggggt gagaattatt attattgact accttcaatt
     8701 gatgaatgcg agtggtatgg cattcggtag ccgtcaggaa gaggttagta cgatatcccg
     8761 ttcgttgaaa ggattggcga aggagttgaa cattcccatt atagccttgt cgcagttgaa
     8821 tcgtggtgtg gagagtcgtg aaggtattga cggtaaacgc cctcagttga gtgaccttcg
     8881 tgaatccgga gccatcgagc aggatgccga tatggtgtgt tttattcacc gtccggaata
     8941 ttataagatt tatcaggatg atcgtggtaa cgacctgcgc ggtatggcgg aaattgtgat
     9001 agccaagcat cgtaatggtg cggtaggtga agtcttgctc cgattcaaag gtgagtttac
     9061 acgattctct aatccggaag atgatatggt tataccgatg ccgggtgaac ctgcaggtgc
     9121 catgctgggg tctaaactga atgccggtgc tatgcctccg cctccgccgg aaccggactt
     9181 tgttccgcag ggaaataatc cgttcggtgc aacggaagga ccgttacctt tctaaaaaaa
     9241 catcttttgg gttgaataga atgaccgctt agtcagatga aaataaccgc tcgatttact
     9301 ccaatcgagc ggtcgattat tttttataga gtatagccaa gttgtattct gatagggata
     9361 ggtggcaaaa atgacaaaga ataccccttt gttttttgcc actttgtcac caaccatgaa
     9421 tttattgggg aataatacag tcaggtcctt gttagtttag cttctcttga catttttctc
     9481 tcaaatcgtt ctatgtcaac cgaaaaatct tattaacttt gcgaaacttt ttgagaaaca
     9541 ataaaaattt aattatatga atatctctta taactggctg aaagagtatg tcaactttga
     9601 tttgaccccc gatgaaacgg ctgctgcgct gacctcaatc ggcttggaaa caggtggtgt
     9661 agaagaagtg caaaccatta agggtggttt ggaaggactc gtaatcggtg aagtgctgac
     9721 ttgcgaagaa catccgaatt ccgaccattt gcatatcact accgtcaatc tgggagacgg
     9781 cgaacctgta cagattgtat gcggtgctcc gaatgtagct gccggacaga aagtagtggt
     9841 tgccactttg ggtaccaaac tttatgacgg tgatgaatgc tttactatca agaagtcaaa
     9901 aatccgtggt gtagaatcta cagggatgat ttgtgcagaa gacgaaatcg gtattggtac
     9961 tgatcatgca ggaatcatcg tgttgccggc tgaagctgtt ccgggtactc tcgccaaaga
    10021 ctattataat atcaagagtg actacgtact cgaagtagat attactccta accgtgcaga
    10081 cgcttgctca cactatggtg tggcccgcga cttgtatgct tacctgattc agaatggcaa
    10141 gcaggctact ttgcaacgtc catctgtaga tggatttaag gtggaaaatc atgatttgga
    10201 tatcgaagta gtggttgaaa acagcgaagc ctgtcctcac tatgccggcg ttacggtgaa
    10261 aggcgttact gtgaaggaaa gccccgaatg gttgcagaat aaattgcgct tgatcggtgt
    10321 acgtcctatt aataatgtag tggatattac taattatatc gttcatgctt tcggtcagcc
    10381 attgcattgt ttcgatgccg gaaagataaa aggcaatgaa gtaattgtca agacattgcc
    10441 ggaaggcact ccattcgtca cattggatga agtggaacgc aagttgaacg aacgcgatct
    10501 gatgatctgc aacaaagaag aagcgatgtg tattgccggt gtattcggcg gactggattc
    10561 cggttctacg gaagctacga cagatgtatt tatcgaaagc gcttatttcc atcctacatg
    10621 ggtgcgtaag actgcccgtc gtcacggtct gaatacggat gcttctttcc gtttcgaacg
    10681 tggcatcgat ccgaacggag taatctattg tctgaaactg gctgctctga tggtgaaaga
    10741 actggccggt ggcactatct catccgaaat taaggatgtt tgcgttgcag ctccacaaga
    10801 ctttatggta gaactttctt atgagaaagt aaattcgctg attggtaaag tgattcccgt
    10861 ggaaacgatc aagagcattg ttaccagcct ggaaatgaaa atcatgaatg agacagttga
    10921 cggactgaca ttagccgttc ctccttatcg tgtagacgta cagcgtgatt gcgatgtgat
    10981 cgaagatatt ctacgtatct acggatataa taatgtagaa atcccgacta cgctgaactc
    11041 cagtctgaca accaagggtg agcatgataa atcaaacaaa ttacagaatc tggttgcaga
    11101 acagttggtt ggctgtggct tcaatgaaat actgaataat tctctgactc gtgccgctta
    11161 ctacgacggt ctggagaact atccatccaa ccatctggtg atgctgctga atccactgag
    11221 tgccgatctg aactgtatgc gtcagacatt gctgttcggt ggactggaaa gcatcgctca
    11281 caatgcaaac cgcaagaatg ccgatttgaa attcttcgaa ttcggtaatt gctattactt
    11341 cgatgcggac aagaagaatc cagaaaaagt actggctacc tattcggaag actatcactt
    11401 gggtttgtgg gtgactggaa agaaagtagc caactcatgg gcacacccgg atgaaaacag
    11461 ttcggtatac gaattgaagg cttatgtaga gaatatattg aagcgcctgg gactggattt
    11521 gcacaacctg gtagttggca atctgactga cgatattttc gctaccgcac tttctgttca
    11581 taccaagggg gggaagcgtc ttgcctcttt cggtgttgtg acgaagaaac tgctgaaagc
    11641 attcgatata gataatgagg tgtattatgc cgacttgaac tggaaagaac tgatgaaggc
    11701 tatccgttca gtgaagatca gctacaagga aatttccaaa ttccctgctg tgaagcgtga
    11761 cttggcattg ttgctcgaca agaacgtaca gtttgccgaa atcgaaaaaa tcgcttacga
    11821 tacagaaaag aaactgctga aagaagtgga actcttcgat gtatacgaag gtaagaacat
    11881 cgaagcaggt aagaaatcgt atgcggtcag cttcctgctt caggatgaaa ctcagacgct
    11941 gaacgataag atgatcgata agatcatgtc taaactggtg aagaatctgg aagataagct
    12001 gaatgcaaaa ttgagataaa tttaaaattc acaattcaaa attaatacaa accaatggga
    12061 agagcatttg aatatagaaa agccgcaaag ctgaaaagat ggggccacat ggctaaaaca
    12121 tttacaagac tgggtaaaca gatcgctatt gccgtgaagg cgggtggtcc ggaaccggaa
    12181 aataacccga cactgcgttc ggtcatcgct acttgtaagc gtgagaatat gccgaaggac
    12241 aatatcgaac gtgcgattaa gaatgcaatg ggtaaggacc agagcgacta caagagcatg
    12301 acttacgaag gatacggtcc tcacggaatt gctgtctttg tagatacgct gactgataat
    12361 acgactcgta cggtagccga tgtacgctct gtattcaata aatttggtgg taacctcgga
    12421 acaatgggat cattggcttt ccttttcgac cataaatgta tgttcacttt caagataaag
    12481 gacggcatgg atatggaaga actgatcctt gatctgattg attacgacgt agaagatgag
    12541 tacgaacagg atgacgaaga aggaacaatc actatctacg gtgatcctaa gagctatgcc
    12601 gctattcaga aacatcttga agagtgtggc ttcgaggatg tcggcggtga ttttacttat
    12661 atcccgaacg atctgaaaga ggtaactccg gaacaacgcg aaactttgga taagatgata
    12721 gaacgtcttg aagaatttga tgacgtgcag actgtttata caaacatgaa gccggaagaa
    12781 ggcggaaacg aggagtaagc ggattatgga atatgtttat agaacccagg gtacttgcag
    12841 cacaaacatc gaactgaatg tagaagatgg agttgtgaag gaagttgcct tttggggagg
    12901 atgtaacgga aatcttcaag gactttcacg tctggtaaag ggaatgaagg tagaagaggt
    12961 tatcaagaaa cttgaaggag tacgttgcag tggcagaccg acgtcctgtc ccgatcagtt
    13021 gtgccatgca ctgcatgaaa tgggatatta acggaagtct ccctttataa aatatacact
    13081 ggcctccggc aattcatttt gccggaggtt ttttattgtg ccgtaccttt ccctatttgt
    13141 cggtattttg aaccaaaatc gaccttcggt cgttatttat aagtatattt gtgctgaata
    13201 aactattatg caatgatgaa gaatattttt caagacttaa aacggaaaga tcataaacgt
    13261 tatctgggcg gactggatgt ttttaaatat attggtcccg gacttttggt aactgtcgga
    13321 tttattgatc cgggcaactg ggcatcaaat tttgccgcag gttccgagtt cggctattca
    13381 cttctttggg tggtcacctt atccactatc atgttgattg tcctccagca taatgttgct
    13441 cacttgggga ttgttacggg gctttgcctt tcggaagccg ctacgaaata tactcctaaa
    13501 tgggtatccc gtcctatttt gggtacggcg gtattggcgt ctatttctac ttcattggct
    13561 gagattctgg gaggagccat cgcattggag atgctgtttg atatgcctat tatgtggggg
    13621 gcggtgctga ccacactttt tgtctccatc atgctcttta ccaactccta taaaaagata
    13681 gaacgttcca ttattgcttt tgtctcggtg atcggtcttt catttattta tgaattgttt
    13741 ctggtagaaa tagactggcc ggctgcgacg atgggttggg tgacgcctgc tttcccgaag
    13801 ggtagtatgc tgattattat gagtgtgctg ggagcggttg tgatgcctca taatctgttt
    13861 ctgcattcgg aagtaataca gagtcacgag tataataaga aagacgatgc gtctatcaag
    13921 aaagtattga aatacgagtt gttcgatacg cttttctcga tgatcgttgg ctgggcaatt
    13981 aacagtgcta tgattctgct ggctgctgct actttcttta aaagcggcat tcaggtggaa
    14041 gaattgcaac aagccaaatc actgcttgaa cctttgttgg gaagtaatgc ggcaatcgta
    14101 ttcgcattgg ctctgttgat ggcaggtatt tcgtccacta taacaagcgg aatggcggca
    14161 ggttctatct ttgcaggtat ctttggagag tcatatcata ttaaagacag tcactcgcag
    14221 gtaggagtaa tcctttcgtt gggaattgcg ctgttgctga ttttctttat tggtgatcca
    14281 ttcaagggat tactgatttc gcagatgata ttgagtattc agttgccttt cacggtattc
    14341 ctgcaagtag ggttgacttc atcccgaaag gtaatgggga attatgtcaa tagccgttgg
    14401 agtacttttg tattatatgc tattgcagtc attgtttcgg tattgaatat aatgctgctg
    14461 ttttcataaa acgaacataa atctataaac tataaaatga tgaagattat tacttataat
    14521 gtgaacgggc ttcgtgctgc cgtttctaaa ggtttgccgg aatggctggt gcaggagaat
    14581 ccggatattc tttgtctgca agagacaaaa ctacagccgg accaatatcc ggcagaagta
    14641 tttgaagctt tgggttacag ggcttatctc tattctgcac aaaagaaggg atacagcggt
    14701 gtggcgatcc ttactaagca ggaacccgat catgtggaat atggtatggg gatagaagct
    14761 tatgacaatg aagggcgttt tatccgtgcg gattttggcg acttgtccgt agtcagtgtt
    14821 tatcatcctt cgggaacgag cggagacgaa cggcaggcat ttaaaatggt gtggctggaa
    14881 gactttcaga aatatgtgac agagctgcgc aagactcgtc cgaaccttat cctttgcggt
    14941 gactataata tctgtcatga gccgattgat attcatgatc ctgtccggaa tgccacgaac
    15001 agcggcttcc tgcccgaaga acgggaatgg atgactcgtt tcctttctgc aggatttatt
    15061 gattctttcc gtctgctcta tccggagaaa caggagtata cgtggtggag ctatcgtttt
    15121 aattcgcgtg cca
//
