LOCUS       gnlProkkaHGLMPHCG_261  15291 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HGLMPHCG_261.
ACCESSION   gnlProkkaHGLMPHCG_261
VERSION     gnlProkkaHGLMPHCG_261
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 16:49:21
            Original ID  :: gnl|Prokka|HGLMPHCG_261
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15291
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15291
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4943:5291]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4944..5291
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15291
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15291
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             3..161
                     /locus_tag="ctg261_1"
                     /transl_table=11
                     /translation="MEDSFRQAIYVAIDVFRNRQREKAARVNPLRKQYYEKRDDSDKLK
                     LDTVDED"
     CDS             285..1526
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 388.8; E-value:
                     6.1e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg261_2"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFAADFAEKYRMPAIQLTEDAKKI
                     LLAYPWPGNVRQLKNITEQISIIETNREITAAILQTYLPAQNTQRLPALFGTRESKSFE
                     SEREILYSVLFDMRQEVAELKKMVHNMMAERAGQVGQMGQVVATPVVTTTHQPSVPAII
                     HAVQQPSVCPKEDDDDIQDTEEYVEETLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             1513..2040
                     /locus_tag="ctg261_3"
                     /transl_table=11
                     /translation="MNWIKKIARPLILVVLPAVIIACSVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             2045..2818
                     /locus_tag="ctg261_4"
                     /transl_table=11
                     /translation="MTSVNLQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             2825..3220
                     /locus_tag="ctg261_5"
                     /transl_table=11
                     /translation="MYLLFIILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSVATAYVVPSSSAAKDVLLEQAQKEQQTNPYNMPTGTAAP
                     QTDATAPAESAPATEASATETPAPAAE"
     CDS             3511..4899
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 90.5; E-value: 1.4e-27)"
                     /gene_kind="transport"
                     /locus_tag="ctg261_6"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKVENKKKGYGLEEA
                     NIQK"
     CDS             4944..5291
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg261_7"
                     /sec_met_domain="PF05402 (E-value: 1.8e-17, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 6.8e-10, bitscore:
                     29.0, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEQEGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQYEAGYESRVSTYLSQLQ
                     KDGFIKWIIIH"
     CDS             complement(5281..5568)
                     /locus_tag="ctg261_8"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLKDGKEASRLRRERRNDKLGRLRRNNDPYLLP
                     DTTPEEMERIIKDSEKKKEKDNNYFVWGTLIIMGVLIGCAVLLWAIFFNG"
     CDS             complement(5590..6654)
                     /locus_tag="ctg261_9"
                     /transl_table=11
                     /translation="MKKLIIATGLLMATSTYAQTEVLTGVTRGKDYGVVYALPKTQIEI
                     EIKANKVNYKPGEFSKYADRYLRLTNVSAEPEEYWELNSVKVKPVGVPNSEATYFVKLK
                     DKTVAPLMELTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMFSGVRNK
                     EEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIPQEDGKK
                     KKEMEGIAYNVPGQAMVTLTDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     VTGGLLKVDREESK"
     CDS             complement(6728..8239)
                     /locus_tag="ctg261_10"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITNRWNP
                     ETPVTIFAGPGNNGGDALAIARMMAEKGYKIEVYLFNTKGELSPDCQTNKELVEMMEEV
                     TFHEISTQFVPPTLTPEHLVIDGLFGSGLNKPLSGGFAAVVKYINASPAMVVSIDIPSG
                     LMGEENTFNVKSNIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEEGIEETET
                     NYEMLEIEEIRSLIKPRQQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPLCNNDILQTSAPEAMVETDVSETCFAVPTDTDDYQAVGIGPGLGRNEETEAALIEQ
                     LEHCQTPTVLDADALNILANHRHTLTHLPKGSILTPHPKELERLVGKCQDSYERLMKAC
                     ELAHTAKVHIILKGAYSAIITPEGKCYFNQTGNPGMATGGSGDVLTGVILALLAQGYPA
                     EDAAKIGTYIHGLAGDIAQKKQGMIGLIASDIVTCLPTAWRLVSE"
     CDS             complement(8705..9538)
                     /locus_tag="ctg261_11"
                     /transl_table=11
                     /translation="MTTKKLTGILSLFLCIICLVSCNDNDDNFSPITLEYEDPQIKFDN
                     ESRSYTLTPFSKETTPLFIKGGDGTYKVTNENEKVVQVNYHNGSLTLKAKEIGRASIKI
                     EDSSNNMYILSVVVKYRTLTHKAFTAKVIVKGDELTSEEHTELMNKVGNSYPINKYVFT
                     FMNAEDSKGTVDLYYSDNNMKTGNFEKEHIVLDEENAIPIKGEYKLSEYYRITIKEDNG
                     KVIDTFYITKNFLPLLNTRMNAHPLIQYCFVRDLTAQYKQDYLALENAYLIQIAE"
     CDS             9811..10035
                     /locus_tag="ctg261_12"
                     /transl_table=11
                     /translation="MMEKKRIGSNAGKVWRILNEKGEQSMFTLCHELGLTFEDVAIAIG
                     WLARENKILLRKKEGMLYASIENVEFTFG"
     CDS             10228..11772
                     /locus_tag="ctg261_13"
                     /transl_table=11
                     /translation="MSSLKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASSLNNTD
                     LAHWLMYGGLGFMILGNGCFKPTVSSLVGQLYEPGDKRLDAAYTIFYMGVNVGSFAAPL
                     ICGFLGDTGNPQDFKWGFLASGIMTLFTVVLFETQKNKYLFSPSGEPIGIVPDARREKK
                     EDKAEHILHPKMDKRTKVRNIIIITALTVALIAFFSYAFSDDWISVGIFTACIVFPVLI
                     LLDGSLTKVERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTDRSIFGWEMPASW
                     FQSFNPLFVVILAYIMPGIWGFLNKRNMEPASPTKQAIGLLLLSLGYLFICFGVKDAIP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEDGKVKSILGYQIATMYDFFMLFVIMSGVASLILFLLSKKLQKMMHGVE"
     CDS             11814..12350
                     /locus_tag="ctg261_14"
                     /transl_table=11
                     /translation="MDTIQIKDKQFTVSIKEQDIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGVTSTGVIKEVIGLNEDIAGRTVVIVEDI
                     VDTGLTMQRLLDTLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             12384..12953
                     /locus_tag="ctg261_15"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLEVPEDELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMDGIFADICEAVDKL"
     CDS             12966..14132
                     /locus_tag="ctg261_16"
                     /transl_table=11
                     /translation="MAESNFVDYVKIYCRSGKGGRGSTHMRREKYCPNGGPDGGDGGRG
                     GHIILRGNRNYWTLLHLKYDRHAMAGHGESGSKNRSFGKDGADKVIEVPCGTVVYNAET
                     GEYLCDVTDDGQEVILLKGGRGGQGNSHFKTATRQAPRFAQPGEPMQEMTVIMELKLLA
                     DVGLVGFPNAGKSTLLSAISAAKPKIADYPFTTLEPNLGIVSYRDGKSFVMADIPGIIE
                     GASQGKGLGLRFLRHIERNSLLLFMVPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLA
                     ITKSDMLDQELMDEIEPTLPEGVPHIFISSVSGLGISVLKDILWEELNKESNKIEDIVH
                     RPKDVTRLQQELKDMGEDEELDYEYEEDADDDDDDLDYEYEEEDWEEK"
     CDS             14156..14941
                     /locus_tag="ctg261_17"
                     /transl_table=11
                     /translation="MLGYESLSSYSNISHFVTTRQGGCSEGNYASFNCTPYSGDEAEKV
                     RRNQTLLMEGMSQTPEELVIPVQTHEANCLLIGDAYLSASSQQRQEMLHGVDALITREL
                     GYCLCISTADCVPVLIYDKKHSAIAAIHAGWRGTVAYIVRDTLLRMEKEFGTSGEDVIA
                     CIGPSISLASFEVGEEVYEAFQKNGFDMPRISIRKEETGKHHIDLWEANRMQILAFGVP
                     SGQVELARICTYIHHDEFFSARRLGIKSGRILSGIMIHK"
ORIGIN
        1 ccagcgaaga ctctttccgt caggctattt atgtagcgat tgatgtattc cgcaaccgcc
       61 agcgcgagaa agcggcacgg gtaaacccgt tgcggaagca gtattacgag aaacgggacg
      121 atagtgataa actaaaactg gatacagtag acgaagatta agtaataggt attaagtaat
      181 aagtattaag tattagccat gcggatggaa gcgagatgat aatgatggta atacttaata
      241 cttattactt aatacttatt acctattact taatattaag atagatgacc aaagcggaga
      301 tacaacaagt gaaacagcgt ttcggtatta ttggcaatac cgaggcttta tcacgtgcca
      361 tagatgttgc cattcaggta gcgcctaccg atttgtctgt gctgattacc ggagaaagtg
      421 gtgtcggaaa agaaagtttt ccacagatca ttcatcaata tagccggaga aagcatgggc
      481 agtatattgc tgtcaactgt ggtgccatac cggaaggtac gatcgattcc gaactgttcg
      541 gacacgagaa aggagcattt accggtgcta ttggtgagcg gaaaggatat tttggagaag
      601 ctgacggtgg aactatcttc cttgatgaag tgggagagtt gccgttgcct acacaggcgc
      661 gtctgctccg tgtacttgaa agcggtgaat ttatcaaggt aggttcatcc aaagtacaaa
      721 agacggatgt acgtattgtg gcagctacca acgtgaacct gacacaagcc attgccgaag
      781 gacgcttccg ggaagatttg tattatcggt tgaacacggt gcctattcag ataccacctt
      841 tgcgtgagcg tggagatgat gtgctgttgt tgttccgtaa gtttgccgca gactttgccg
      901 aaaagtaccg gatgccggct atccagctga cggaagatgc caagaagata ttgcttgctt
      961 atccgtggcc gggaaacgtc cggcagttga agaacatcac agagcagatt tcgattatag
     1021 aaacaaaccg tgagataacg gctgcgattc tgcagaccta tcttccggca cagaataccc
     1081 aacgccttcc ggcactgttc ggcacacgcg agagcaagag ctttgagagc gaacgcgaaa
     1141 tactatattc tgtcttgttc gatatgcgtc aggaagtggc ggaactgaag aagatggtgc
     1201 acaatatgat ggctgaacgt gcgggacaag tcggacagat gggacaggta gtagctactc
     1261 cggtagtgac aacgacgcac caaccttccg tgccggccat tatccatgct gtgcagcaac
     1321 cgtctgtttg tcccaaagaa gacgatgacg atattcagga cacggaagaa tatgtagaag
     1381 aaaccctttc gctcgatgaa gtggaaaaag aaatgatacg taaagcgctt gagaggcatc
     1441 atggtaagcg gaaaagtgcg gcgaaggatc tgaatatctc cgagcgtacc ctttacagaa
     1501 aaataaaaga atatgaattg gattaagaaa atagcacgac cgctgatatt ggttgtttta
     1561 ccggcagtca tcatcgcctg tagtgtgtcc tataagttta atggctcctc tatcaattac
     1621 gataaggtga agactatttc gattgctgat ttcccgatta agtcggagta tgtgtatgct
     1681 ccgctggcta ccaagttcaa tgaagacctg aaagatatct tcatcagaca gacccgtctg
     1741 caactgctga aaccgaacca gaatgcggat ctgcagattg acggtgaaat tacgggctac
     1801 aaccagtata accaggcagt gtctgccgat ggttactctt cggaaacgaa gctgaccatc
     1861 acggtcaatg tacgctttgt caacaacaca aatcacgccg aagacttcga acaacaattc
     1921 tcagctttcc gtacctatga ttccagccag ctgctgacgg ccgtacagga tggattaata
     1981 gcggaaatga gtaaagagat aaccgaccaa atatttaatg caactgtagc aaactggtaa
     2041 tttaatgact tctgttaact tgcaacaatg gattcagcat cccgagacgc tgaataggga
     2101 tactttgtac gaactgcgca atcttcttgc gaggtatccg tattttcagt cacttcgtct
     2161 gctgtatctg aagaatctgt atattctcca tgatattagt ttcggtggag aactgcggaa
     2221 agcagttctt tacattgcag acagacggca gttgttccgg ttgattgaag gtgaccgcta
     2281 tgatgtgcag gcacggaaaa agggagtacc tctcacggag gtgttgaaag acgaaccgtc
     2341 cgtagaccgc acattagcat tgatcgacgc tttcttgtcc acagtacccg aagaggtgac
     2401 tgcccgcacc agcttcgact attcgatgga ttacacctct tatcttttgg aggagactcc
     2461 ggccacggaa cagtcggccg aagaaacgcc caaactcaaa ggctacgaac tgattgacga
     2521 ctttatagaa aagagcgaga gcgactctcc cctctgcaag aaacctttaa gagaagaaat
     2581 gccatcttcg ccaacctctt cggacgaact taccgaagaa gaaacgatga aggaagaaga
     2641 ggaagatgac agctgtttta cggaaacttt ggcaaaaatc tatgttaaac agcaacgata
     2701 ttcaaaagct cttgaaataa ttaaaaaatt aagcttgaaa tatccaaaaa aaaatgctta
     2761 ctttgcagac caaatcagat ttttggagaa attgattatt aacgctaatt caaaataact
     2821 aaaaatgtac ttattattca ttatcttaat ggtgattgca gccttgctga tgtgcttcat
     2881 cgtgctgatt cagaattcaa aaggaggcgg acttgcttct ggtttttctt catcaaacgc
     2941 tatcatgggc gtgcgcaaga ctacagattt tctggaaaaa gcaacttggg gtctggctat
     3001 cttcatggtt gtgatgagcg ttgctactgc ttacgttgtt ccttcttctt ctgcggctaa
     3061 agatgtattg ttggaacaag cacagaaaga acaacaaacc aacccgtata atatgcctac
     3121 cggtactgct gctcctcaga cagatgctac tgctcctgca gagtctgcac cagcaacgga
     3181 agcttcggct actgaaactc ctgctcctgc agcagaataa ttcagtgaca ggatattcgg
     3241 tttaaactta ttgagtgaac gggctttttg acccgttctc ttcattatag gcgcgaatta
     3301 cgcgaattac aagagattct aatagaatcg tgtaatacgt gtagttcgcg cctgtcttta
     3361 ttattgggcc cggtctgctc ttcttcatac aggaatatcc ggtcagatgt cctttttctt
     3421 ataaaatgtt ctcctttttt agtaaaacaa atgataatta gttaactttg ttgcccgtta
     3481 cgagattatt aactcctttt aaatattaca atgacagaac aattgaaaca aaagctgaat
     3541 gactccgcag tgctgcgttg gagtgttcta gcattagtcg cttttaccat gttgtgcggc
     3601 tacttcctca cagacgttat gtctcctctg aaacccatgc ttgaaaaaga acttctctgg
     3661 gacagtttag attacggttt tttcaccagt gcttatggct ggtttaatgt attcctgctg
     3721 atgctcatct ttggtggtat cattctggat aagatgggag tacgcttcac cggaatgggt
     3781 gcctgtttat tgatggtgtt cggttgtgga ttgaaatatt atgctattac tactactttc
     3841 ccggaaggtg cgatgctttt cggattcaag atgcaagtca cattggctgc attgggttat
     3901 gctattttcg gtgtaggagt cgaaattgcg ggtatcaccg tttcgaagat tatcgtgaag
     3961 tggtttaaag gcaaagagat ggctctcgct atgggactgg aaatggcgac cgcgcgtatt
     4021 ggaacgactt tggccatggt gcttaccgtt cctttggcag acttcttcgg gtctacggat
     4081 gagagcggcg tattccatac caatattccc gctcctattc tgttctgtct cgtcatgttg
     4141 tgcgtaggta ccatcgcatt cttcatctat actttctacg ataagaaact ggatgcttca
     4201 ctggatgcgg aaggactgga accggaagaa cctttccgca tgaaagacat tgtctatatc
     4261 attaccaaca aaggattctg gctgatcgca ttactgtgcg tattgttcta ttcggctgta
     4321 ttccccttca tcaagtatgc ggccgatttg atggtacaga agtacaatgt tgatccgaaa
     4381 cttgcgggaa cgattcccgg attgctgccg attggcgcga tcatcctgac accgttgttc
     4441 ggttcattat atgaccgtat cggtaaggga gccacgctga tggtgatcgg gtcggtgatg
     4501 ctgattttcg tacacacgat gttcgctctt cctattctga atatatggtg gtttgcaacg
     4561 gtgatcatga ttattctggg atttgctttc tcattggttc cttcggcaat gtggccttcg
     4621 gttccgaaga ttattccgga gaaacagttg ggaacggctt atgcgttgat cttttgggta
     4681 cagaactggg gattgatggg cgtgcctttg ctgatcggat gggtgttgaa ttcttattgc
     4741 aaaggtccgg ttgtagatgg tgcacagact tatgattata ctttgccgat ggctattttt
     4801 gctatgttcg gtgtacttgc cctgattgtt gccttgatgc tgaaagtgga aaacaagaag
     4861 aaaggctacg gactggaaga agcaaatatt cagaaataat cacagtatat attctatctg
     4921 aaaagatata aaagagaaaa gatatggcta cgaaagagaa aataaacctc ctggaggtga
     4981 tcccttgtcg taacgaacat attaaagctg aacaggaagg ggagactatt gtgctctcct
     5041 tccctcgttt taaacgttcg tggatgagtc gttatttatt gccgaaagga atgtccaaag
     5101 atattcatgt gcgtctggaa gaacacggta cggctgtatg gaacctgata gacgggcagc
     5161 ggacggttcg tgagattata gaaaaactcg cagaccactt tcaatatgaa gcaggctacg
     5221 agtctcgtgt atctacctat ctttcccaat tacagaaaga cggatttatt aaatggataa
     5281 ttatccatta aaaaagattg cccacaggag gacagcacat cctatcagta cgcccataat
     5341 gatgagcgtt ccccatacga aatagttgtt atctttttct tttttctttt ccgaatcctt
     5401 gatgatgcgt tccatctctt ccggagtcgt atccggcaga agataagggt cgttgtttct
     5461 tctaagtcgc cctaacttgt catttctccg ttcacggcgt aagcgggagg cttctttgcc
     5521 gtctttcagc cgacgtatca tgtcgagcat atgtccttcg ccacccatcg ttttgttttt
     5581 ttagaggttt tatttgcttt cttctctatc tactttcagt agtccaccgg tcaccggatc
     5641 aaagtaaact ttgatggtcg agttcttgtt gaataatacc ggagcaaggt attctatgat
     5701 accgaactga gtaacaggta tttctccttc atacaatttc tttttgccgt ccgtcagcgt
     5761 caccattgcc tgtcccggta cgttataagc aatgccttcc atctctttct tctttttccc
     5821 gtcctcttgc ggaatcttca ccgttttcag gtctttcaga ctgatgtaga atggagtgcc
     5881 tgccaaatcg ttgttagcaa ctatacccag cttctttgaa aagcggaaag ctacctcatt
     5941 gtcgaattcc ttatccggag tgaggcggac agtaaatgtc ttttcttctt tattgcggac
     6001 tcccgaaaac atctcggtca tggcttcttc ctgaagattc aggttgtcga gcatgatttt
     6061 gagctgtgcg ccgtccgaag gcatattatc tgcttgtccg cgcaataatg cgtttttact
     6121 ttcgcggata ttatagattt cctttgctac cagttcggcc atcttggcgg ttgaacttgc
     6181 catcagaatt tcttctgtga gaaagtcgcg gggattggct tttcgttggg gagcaacggc
     6241 attgtttgct gcattctttg cattgttact gctgtagggg acattgattg atttgataag
     6301 accctcttca gtcagttcca taagaggagc tacggttttg tctttcagtt tgacgaaata
     6361 agtagcttcg ctgtttggta cacctacagg tttcactttg acactgttca gttcccagta
     6421 ttcttcgggt tcggcagaga cgttggtcag tctcaggtag cggtcggcgt atttgctgaa
     6481 ttcacccggc ttatagttga ctttgtttgc ttttatttct atttctatct gggttttggg
     6541 gagggcgtac actactccgt agtcttttcc tcgcgtcact cctgtcagca cttcggtctg
     6601 cgcataggtg gaagttgcca ttagtagtcc tgttgctatg attaactttt tcatattcgg
     6661 ttctttttag ctgattttga aaaacaaagt taatgaagtt attgaataaa ccgtaagttc
     6721 ttaactttta ttcgcttaca agtcgccatg ccgtcggcag acaagtcacg atatcacttg
     6781 cgattaatcc gatcatgccc tgttttttct gggcgatgtc tccggccaat ccgtgaatgt
     6841 aagtaccgat ctttgcggcg tcttcggcgg gatagccttg cgcaaggagt gcaaggatta
     6901 ctcctgtcag tacatctccg ctgcctcctg ttgccatacc gggattaccg gtctggttga
     6961 agtaacattt gccttcgggg gtgataatgg cggaataagc tcccttcaga atgatatgta
     7021 ctttggcagt gtgcgccagt tcgcaggctt tcatcagtcg ttcgtatgag tcctgacatt
     7081 tgccgaccag gcgttccagc tctttcgggt gaggggtgag gatggaacct ttcggcagat
     7141 gggtgagcgt atgccggtga ttggccagaa tattgagtgc gtcggcatcc agtaccgtcg
     7201 gagtctgaca atgttccagt tgttctatca gggcggcttc cgtttcttcg ttgcgaccga
     7261 gtcccggacc gatgccgaca gcttggtaat cgtccgtatc ggtaggtacg gcaaagcatg
     7321 tttcgctgac atctgtttct accatggctt cgggggcgga cgtttgcaga atatcgttgt
     7381 tgcataacgg cgcgtgtacc gtcagcagac ctactcccga tcgcaaacag gcacgggcgg
     7441 ccagtaccga tgcacctgcc attccttttg agccggctat cagcagggca tgtccgaagt
     7501 ttcctttatg ggcgaattgt tggcgtggtt tgatcagtga acggatttct tcgatttcca
     7561 gcatttcgta gtttgtttca gtctcttcga ttccttcttc gctcagctgg atgtccaata
     7621 actcccattc gccaacaaat tctgtatttt cggcaaagag gaaggccagt ttaggaagtt
     7681 gcaggctgaa agtgacgtcc gcacggataa tattgctttt tacattgaat gtattttctt
     7741 ctcccatcag cccggaaggg atgtcgatgg agactaccat ggcgggagag gcattgatat
     7801 atttcacaac ggcagcgaat cctccgctca atggtttgtt gagtccggaa ccgaataatc
     7861 cgtcgatcac gagatgttcc ggtgtcagtg tgggaggtac gaactgggtg ctgatttcat
     7921 ggaaagttac ttcttccatc atctctacca gttctttgtt ggtctggcag tcgggcgaaa
     7981 gttcgccttt cgtgttgaag agatatactt cgatcttgta tcctttttcc gccatcatgc
     8041 gggcgatggc gagggcgtct ccgccattat tgcccggtcc ggcaaagatg gtgacaggtg
     8101 tttccggatt ccatctgttg gtgatggctt tagtcagtgc ctgtgcggca cgttccatta
     8161 aatctatgga tgcaatcggt tcatgttcaa tggtataggc atctaacttc ttaatgctgc
     8221 tgcttggaaa tattttcatt gcgatattct tttagttttc gacgcacaaa cttacacaaa
     8281 aactctgaat taatccttta ttccggttgg ttttcggctt tttgggaagg aacttcaggt
     8341 attaatactt gagttgtcag gtattaatag ttgatgtgtc agttattaat agttgagaag
     8401 tcagatatta atgattgtta tctcatttac ttttactctc tccggagaac attcatggct
     8461 gtttgttaac cttcccatgc gtgtttctac tactgtatat tcctctggtt cacctctttc
     8521 acccgcaatc gccttattca tcaaaggttc aggaaaaggg tggaagaggt gattgtgata
     8581 aatatgctat gggcatattc ttgattagct aatagcttat tgttttttgc taaatctaat
     8641 ggggagtttg ctcatataat aaatactcta ttcactctgc taaagaagaa aatcagtgta
     8701 gctctcattc tgctatttga atcagatatg cattttccag tgcaaggtaa tcttgtttgt
     8761 actgtgcggt taaatctctg acaaaacagt actgaattaa cggatgagca ttcattcttg
     8821 tattgaggag tggtagaaag ttcttggtaa tatagaaagt atcaataact ttgccattat
     8881 cttctttgat tgttatacgg taatactcac tcaatttgta ttcacctttg atgggaatgg
     8941 cattttcttc atccagcact atatgttctt tttcaaagtt gcctgttttc atgttattat
     9001 ctgaataata caaatctact gttcctttgc tgtcttccgc attcataaaa gtaaatacat
     9061 atttattaat cggatatgaa ttgcccactt tgttcattaa ctcagtgtgt tcttcagatg
     9121 taagctcgtc tcccttcaca atgacttttg ctgtaaacgc cttatgagta agagtacgat
     9181 attttacaac gacagacagt atatacatat tattcgaact gtcttctatc ttgatggatg
     9241 cgcgtcctat ttcctttgcc ttcaatgtta aacttccgtt gtggtagttt acttgtacca
     9301 ctttctcatt ctcattggtc actttgtaag ttccgtctcc acccttgatg aagagtggtg
     9361 tcgtttcttt gctgaacgga gtcagtgtgt aagaacggct ctcgttgtcg aacttaattt
     9421 gaggatcttc atattccaga gtgattggag aaaagttgtc atcattgtca ttacagctca
     9481 cgaggcaaat aatacaaagg aataacgaaa gtattcctgt tagttttttg gtagtcatgc
     9541 taattaaagt tttaaatgtg cgatattagt ttagttctcg tctgcaaact tatgaaaaag
     9601 aattgaactg tttctttatt tgtgctattt tttagcagag atcggcataa atgattagaa
     9661 tgtaactaat aatagcagct aatgctttga ttatttgctt ttttcgaaaa aaatgatatc
     9721 tttgtagtgc agtaatgtgc tttacgttat tctcctgtgc tcacaatgtt tagattataa
     9781 atataaattg tttaatcttc taaagtttgc atgatggaaa agaaaagaat tggctcaaat
     9841 gccgggaaag tatggcgcat cttaaatgaa aagggcgaac agtctatgtt cactttgtgc
     9901 catgagttag gtttgacgtt cgaggatgta gcgattgcta tcggttggct ggcaagggaa
     9961 aacaaaatcc tgcttagaaa aaaagaagga atgctctatg ccagtattga gaatgttgaa
    10021 tttacctttg gataaatggg gactgaccca catttaagga gaatatccac ttgattattt
    10081 acactgttga aaacataata aggtgggtaa ctgagacttc ttgcacgcca tcctgtattt
    10141 ttctattcca taagaatctt cttttttgag gcatttaatc tactttttag tacctttgcg
    10201 ccccataaac tactaaacac ataattcatg agttcattga aagggcaccc gaaaggcctt
    10261 tacctaattt tcgcaacgag cacggcagaa cgtttcagtt actacggtat gcgtgctatc
    10321 tttatcctct ttctgacgca ggcattgctt tttgataaag aagcggcggc ctctatctac
    10381 ggtagctaca ccggactggt ctatctgact ccgttgatcg gcggatacat tgccgataaa
    10441 tattggggta tccgtcgttc ggtattttgg ggagcggtga tgatggcagt cggtcagttc
    10501 ctgatgttta tgagtgcctc ttcactgaac aatacagacc ttgcccactg gctgatgtat
    10561 ggcgggctcg gattcatgat tttaggtaac ggttgcttta agcctaccgt ttcttcgctc
    10621 gtcgggcaat tatatgaacc cggggacaaa cggttggatg ctgcatacac cattttctat
    10681 atgggtgtta atgtaggttc tttcgccgct cctttgattt gcggtttctt gggagacaca
    10741 gggaatccgc aggactttaa atggggattc ctcgcatccg gaatcatgac gctgttcact
    10801 gttgtcctct ttgaaactca gaagaataaa taccttttct ctccttccgg tgaaccgatt
    10861 ggtatcgtcc ccgacgccag acgtgaaaaa aaggaggata aagccgaaca tattttacat
    10921 ccgaagatgg acaaacgtac caaagtacgt aatatcatca tcattactgc ccttacggtt
    10981 gccttaatag ccttttttag ctatgccttt agcgatgact ggattagtgt gggtatcttt
    11041 acggcttgta ttgtctttcc agtgctcatt ctgctggatg gttcattgac caaagtagaa
    11101 cgtagccgta ttttcgtaat ctatatcgta gctttcttcg tcattttctt ctgggcagct
    11161 tacgagcagg caggagcttc tctgacatta ttcgcttccg aacagactga ccgcagcatt
    11221 ttcggctggg agatgccggc ttcgtggttc cagtcattca atccgctttt tgtagtgatc
    11281 cttgcctata ttatgcccgg tatatggggc tttctgaata agcgaaacat ggaaccggct
    11341 tcccctacca aacaggcaat cggtctgttg ctgctttctc ttggttatct cttcatctgt
    11401 tttggagtga aagatgctat tccaggagta aaggtgagca tgatctggct gacagggctt
    11461 tactttattc atacaatggg agaaatcgct ctgtcaccta tcgggctttc tatggttaat
    11521 aagttgagtc cgttacgttt cgcctccttg atgatgggga tctggtatct ttctaccgcc
    11581 accgcaaata aatttgcagg tatgctgagc ggcctctatc ccgaagacgg aaaagtgaaa
    11641 tcaatccttg gttatcagat cgctaccatg tacgacttct tcatgctgtt cgtcattatg
    11701 tccggtgttg cctcactgat tctgttcctt ctctcgaaga aattacagaa gatgatgcac
    11761 ggggtagaat aaaaaattgt atttttgcga caactttttt aaaatgaccg gttatggata
    11821 ccatacagat aaaagacaag caatttactg tttccattaa ggaacaggat attcaaaaag
    11881 aagtgattcg cgtagcgaac gaaatcaatc gtgatttggc aggtaagaat ccgctcttcc
    11941 tcagtgtgtt gaacggctcg ttcatgttta ccgccgactt gctgaagcat attacgattc
    12001 cgtgcgaaat ttcattcgtg aagttggcat cttatcaggg ggtgacttcc accggagtaa
    12061 ttaaagaagt gatcgggctg aatgaagaca ttgccggacg tacggtagtg atcgtagaag
    12121 atattgtaga taccggactg acgatgcagc gtctgctgga tacactgggc acacgcaacc
    12181 ccgaagcgat tcatatcgcc tctttgctgg tgaaaccgga aaagctgaag gtcaatctga
    12241 acatagaata cgtagcgatg gaaataccga atgattttat cgttggctac ggattggatt
    12301 atgatggttt cggacgcaat tatcccgata tttatactgt agtagattaa attcaaatac
    12361 aaattaattt ttaggttaaa aagatgttga acattgtaat tttcggtgct ccgggttcag
    12421 gaaaaggaac gcagagcgaa cgtattgtag aaaagtatgg aatcaaccac atctcgacag
    12481 gagatgtatt gcgtgcagaa atcaagaacg gcacggaact gggcaaaact gctaaaggtt
    12541 acatcgacca gggacagttg attccggatg aattgatgat tgatattctg gcaagcgtat
    12601 tcgatagctt caaagacagc aaaggtgtaa ttttcgacgg tttccccaga acaatagcac
    12661 aggcggaagc attaaagaag atgttggccg agagaggaca ggatgtttct gtaatggttg
    12721 accttgaggt gccggaagat gaacttatgg tacgtctgat taagcgtggc aaagactccg
    12781 gccgtgctga cgataacgaa gaaactatca aaaaacgtct gcatgtatat cattcacaga
    12841 ctgctccgct gattgactgg tacaagaacg aaaagaaata ccagcatatc aacggtctgg
    12901 gtactatgga tggtatcttc gctgatatct gcgaagcagt agacaaattg taataaataa
    12961 aaaatatggc tgaatcgaat tttgttgatt acgtaaagat atactgtcgc tcaggcaagg
    13021 gcggaagagg ctctacgcac atgaggcgcg agaaatattg tcctaacgga ggtcccgatg
    13081 ggggcgatgg tggaagagga ggccatatta tcttgcgcgg taaccgtaat tactggacat
    13141 tgcttcactt gaagtatgac cgtcatgcga tggcaggtca tggcgaatcg ggcagcaaga
    13201 accgtagttt cggaaaagac ggtgcggata aagtgatcga agtaccctgc ggaacggtag
    13261 tgtataacgc cgaaaccgga gaataccttt gcgatgtgac ggacgacgga caggaagtga
    13321 tcttgctgaa aggcggtcgt ggcggtcagg gcaacagtca tttcaagacg gctacccgtc
    13381 aggctccgcg ctttgcgcag ccgggcgaac cgatgcagga aatgacggtg atcatggagc
    13441 tgaaactgtt ggcagatgta ggactggtag gtttcccgaa tgcgggaaag tctacgttgc
    13501 tttctgccat ttcggctgcg aaaccgaaga ttgccgatta cccgtttacg acactcgaac
    13561 cgaatctggg aattgtttcc tatcgcgatg gaaagtcatt cgtgatggcg gacataccgg
    13621 gcatcatcga gggagccagt cagggaaaag gattgggact gcggtttctg cgtcatatcg
    13681 agcgtaactc gttgctgttg ttcatggttc cggcagatag cgatgatatc cgcaaggagt
    13741 atgaagtatt gctgaatgag ctgcgtacgt tcaatcccga aatgctggac aaacaacgtg
    13801 tgctggctat cacgaagagc gatatgctcg atcaggagct gatggacgag attgaaccga
    13861 cattgcccga gggtgttccg catatattca tttcttctgt ttccggtttg ggaatctcag
    13921 tgttgaaaga cattctgtgg gaggaactga acaaggaaag taataagata gaagacattg
    13981 ttcaccgtcc gaaagacgtg acccgtctgc aacaggaact caaggacatg ggcgaggatg
    14041 aagaactcga ctatgaatat gaggaagacg ctgacgacga cgatgatgat ctcgactacg
    14101 aatacgaaga agaggattgg gaagaaaaat gatttcaatc acaagagata aaagaatgtt
    14161 ggggtatgag tcgttaagct catactccaa catttctcat tttgtaacta cccggcaggg
    14221 agggtgcagc gaaggaaatt atgcgtcatt caactgtacg ccctacagtg gagacgaggc
    14281 ggaaaaggtc cggcggaatc aaacgcttct gatggaagga atgtcgcaga cacccgaaga
    14341 actggtgatt cctgtgcaga ctcatgaggc gaattgcctg ctgatcgggg atgcttattt
    14401 atcggcttcg tctcaacaac gacaggagat gctgcacgga gtggatgctt tgattacccg
    14461 cgagttggga tattgccttt gcatttctac tgcagattgt gttcctgtgt tgatatatga
    14521 taagaaacat agtgccatag ctgccattca tgccggatgg agagggacgg tagcatacat
    14581 cgtgcgtgat actttgttgc ggatggagaa ggagtttggc acaagtggag aagatgtgat
    14641 agcctgtatc ggtccgagta tctcattggc ttcttttgaa gtgggtgagg aagtgtacga
    14701 agcatttcag aagaatggtt ttgatatgcc tcgtatttct atcaggaaag aggaaaccgg
    14761 aaaacatcat atcgacttgt gggaagcgaa ccggatgcaa atccttgctt tcggtgtgcc
    14821 gtccggacaa gtggagcttg cccggatatg tacgtatatt catcacgacg agtttttctc
    14881 ggcaaggcgt ttgggcatta agtccggacg gattctgtcg gggatcatga ttcataaata
    14941 atagacttga acgtaagttg atataaactt gaataaaagt atgtttgaaa taaaagtatc
    15001 tcaggaaata aagaacgcct gccctgtttt tgccggagca gccgtatatg cagcagtgaa
    15061 gaatactgct tattgcgatg gactttggaa agaaataaat attttcacag aagacttgac
    15121 taccaccacc caaatggcag acattaagtt gcaacctgtg attgctgcta cccgtgaggc
    15181 ttataagcgt tgcggaaaag atccggggcg ttatcgtccg tcggcagaag cgctgcgccg
    15241 tcgcctgatg cgtggcatcc ctttgtatca gattgatact ttggttgacc t
//
