LOCUS       gnlProkkaHGLMPHCG_65   11314 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HGLMPHCG_65.
ACCESSION   gnlProkkaHGLMPHCG_65
VERSION     gnlProkkaHGLMPHCG_65
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 16:49:21
            Original ID  :: gnl|Prokka|HGLMPHCG_65
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11314
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11314
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2000:6314]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2001..6314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11314
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11314
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             2..778
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 34.9;
                     E-value: 1.2e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg65_1"
                     /transl_table=11
                     /translation="MFSLKDGFVIDGQPGFILEPYDQVYVRRSPGYQAQQNVAIEGEIL
                     FGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKKRMGDVIRLMSRQLG
                     EAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIPKNTNTVTINGAVMV
                     PNTVSYMKGKNVDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIV
                     PGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             789..1937
                     /locus_tag="ctg65_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             2001..2720
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.4e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2741..4042
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.9e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.4e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             4059..5183
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.6e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             5193..6314
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg65_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_6"
                     /sec_met_domain="Aminotran_5 (E-value: 2.3e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        5283..6290
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg65_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg65_6_Aminotran_5.1"
                     /locus_tag="ctg65_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             6311..6454
                     /locus_tag="ctg65_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             6657..8141
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_8"
                     /sec_met_domain="Polysacc_synt (E-value: 2e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             8095..9354
                     /locus_tag="ctg65_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             9363..10112
                     /locus_tag="ctg65_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             10112..11152
                     /locus_tag="ctg65_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 taccttctct ttaaaggatg gttttgtaat agatggtcag cccggtttta tccttgagcc
       61 ttatgatcag gtttatgtcc gtcgcagtcc gggctatcag gcacaacaga atgtagccat
      121 tgaaggtgaa atccttttcg gaggaaatta cgccatgacc agccgtgagg aacgtctttc
      181 cgatttagtg aataaagccg gcggtccgac caattatgcc tatctgcgtg gtgcgaaact
      241 gacccgtgtg gctaacgcta gtgaaaagaa acgtatgggt gatgtaattc gccttatgag
      301 caggcaattg ggcgaagcca tgattgactc tttgggtatt cgtgttgaag atacttttac
      361 ggttggaata gatttggaaa aagccttgag caatcctaaa agtaatgccg atcttgtctt
      421 acgtgaaggt gatgtgatct ccatacctaa gaatactaat actgtaacta tcaatggtgc
      481 tgtcatggtt ccgaatacgg tttcttatat gaagggcaag aatgtggatt attacctgaa
      541 tcaggccggt ggttattctg ataatgcaag gaagagtaag aaattcattg tttacatgaa
      601 tggtcaggtg acgaaggtta agggtagtgg taagaaacag attgagccgg gatgtgagat
      661 tattgtgcct ggtaaggcta agaagaaagg gaacatagct aatattttag gttatgctac
      721 ttccttcagt tctttgggaa tgatgattgc ttctattgct aatttgataa agaaataaat
      781 gacctattat gattgaaaag caatcttatc aagaaccgtt ttctgaagtg gataaaagga
      841 aagatgatga aatggaaata gacttgatgg ctatttttta taagattatt actgttcgtg
      901 gagtactatg caaagctgct ggagtgggag taataattgc tatagtggtg gcattgagca
      961 ttcccaagca atatacagta aaggttaccc tttctcctga aatgggtaat gcgaagggaa
     1021 gtaatggttt agccggactt gctgcctcgt ttttgggaga tggggctcta ataggggaaa
     1081 gcacagatgc cttgaacgct tctctttcag cagatattgt ttcttcaact ccttttttat
     1141 tggaactttt agaaatggaa gtctccgttt ctaaaaagga tgataaaatg actttggggt
     1201 cttatctcga tgaagagtca tctccttggt gggattatct tataggtttt ccgggcatag
     1261 taataggagg agttaaatca ttattcggag aagatacggt tcctgccagt ggagggcggc
     1321 aaggaactat cgaattgacg aaagaagtaa atgagaagat taattttctt aaaaagaaga
     1381 ttagtgcatc cattgataag aaaaccgcca taacgagcat tacggtcacc ttacaaaatc
     1441 cgcagatcac tgcggttata gcagattctg tcgttcataa attacaggaa tatattattg
     1501 ggtatcgaac ttcaaaagta aaagaagact gtgcgtattt ggaacggttg tttaaagaac
     1561 gtcagcagga atattatgct gctcaaagaa aatatgcgga ttatgtagac gcccatgata
     1621 atgtggttct tcaaagtgta cgtgctgagc aggagcgttt acagaacgac atgagtttgg
     1681 cttatcagat atatagtcag gttgctaatc agttgcaggt atccagagcc aaagtacagg
     1741 aggaaaagcc agtctttgca gtagttgagc ctgccgttgt acctttgaaa ccttcaggta
     1801 tgggactcaa aatttatatt ttattatttg tgttcctgtc cgtatctggt actctcgtgt
     1861 gggtgttttt tggcaaaagt ctgctggcta gcttgagaaa agaactgaaa aataaggaga
     1921 tagaacagga taaatgatgc taaaacgtcg tttacaacat tcttacatca attaaattca
     1981 cttactatat tattaaacga atgatacgta cagctatgat aatggctgcg ggcatgggaa
     2041 cccgttttgg ccaatataca gaattgatac ctaaagggtt cgtcaaagtg ggaggtattc
     2101 caatgatagt tcgttctatt gatactttgt tatcatgtga cattgagcga attgtaatcg
     2161 gtacaggata taaacaagaa gtttatgaag aattgaagac agactatcct atgcttgaaa
     2221 cctgttttag tcctcgttat gctgaaacaa atagtatgta tactttatat aatacgcggg
     2281 agattctggg caatgatgat tttttattgt tagagtcaga tttgattttt gagaaacaag
     2341 caataatgag cttattggag tgtcctgcgg cagatgcaat gctaataact ccagtgacaa
     2401 agtttcaaga tcagtattat gtggaacatg atgataattt tcgcctttct tcatgttctg
     2461 tcaataagaa taaactaaac gctaaaggcg aattggtcgg catccataaa ctatccggtt
     2521 ccttttacaa aataatgtgt gctgattatg cgagtattgt tgatgaacaa cccaatttgg
     2581 gatatgagta tgaattacta cgaatatctt gttctcaatc tcctgtttat gtgcataaag
     2641 tagaagggct gaaatggtat gaaatcgatg acatatcaga tttggaatat gcagagaaat
     2701 atattgttcc gtattgttaa ttaaaataat atatcaaatt atgagtaaga cagtttatat
     2761 tgggatgact gcggatatta tgcatccagg acttatccgc attattaatg aggctactaa
     2821 atacggtgat gttataattg gtcttcttac agataaagct attgcggagc ataaacgcct
     2881 tccttatctg acctatgaac aacgaaaaga ggtagttcag aatattaaag gcgtatgtaa
     2941 agttgttcct caagaagaat ggagctatgt tgagaatctc aaacgcatta aacctgacta
     3001 tataattcat ggtgacgact ggaaaaccgg gcctttacgt gaagaacgtg tgcgcgtatt
     3061 tgaagtgatg aatgaacagg gaggaaaggt tatcgaaatt ccatatactt tgggaattaa
     3121 ttcatcttct ttggataaag atattaaggc tataggtaca acccctgatg tacgtttaaa
     3181 atcacttcgt cgtttgataa atgccaaacc cgtagttcgt attttggaag ctcatgatgg
     3241 actatgtggc ttgataattg aaaatcagga aatattaaaa ggggataaga gggaagtatt
     3301 tgacggaatg tggtctagta gccttacgga ttcaaccagt aaaggtaaac ctgatattga
     3361 ggcggttgat ttaactaccc gattgcaaga tttgaataat attctggagt gtactactaa
     3421 acctattatt tttgatggag atacaggtgg taaaattgaa catttcgtat ttacagtacg
     3481 cactttagaa cgtcatggaa tttcagctat aataattgaa gataaagttg gattaaaaaa
     3541 gaattcattg tttggtacag atgttattca aactcaagat acaatcgaag gtttctgtaa
     3601 taagatcaaa gcaggaaagg catctcagat tactgatgat tttatgatta tcgctcgtat
     3661 tgagagcctt atagcgggaa agccggtaag tgatgcttta gagagagctt ttgcatatgt
     3721 ccaagcggga gcggacggta ttatgataca tagcaaaaat aagtcgggtg aagatataaa
     3781 agaattttgt ttggcgtttc gaaaacagta tgctcatgta cctatcgtgg ttgtgcctac
     3841 tacatatgat catatttatg agtctgaatt gtgtgattgg ggtgtgaata taattattta
     3901 tgctaatcat atgcttcgtg ccgcttatcc tgctatgatg aatgtcgcaa agataatatt
     3961 agagaatgaa cgtgctttag aggtgcgcga actgtgtatg cccataaaag aaatattgga
     4021 actgattcca ggtactaaat aaaaagagga atatcattat gttaagcgta gaaaaagttt
     4081 atgaaacgtt tctgagtcat gacgttgatt tttttacagg agttccagac tcattactaa
     4141 aaaatatttg tgcctatatc acagaccata cttcacgtga gaaacatatc atagctgcta
     4201 atgaaggtgc ggctgtagga attgcttcag gttattatat ggcatcaggt aaggttcctg
     4261 tggtttatat gcaaaattcc ggcttgggta atactgttaa tcctctgctg tctcttgcag
     4321 atgaacaagt atacagtttt ccaatgcttt tgatgattgg ctggcgtggt gaaccgggaa
     4381 caaaagatga acctcagcat aaaaaacagg gtgaggtaac tttagatttg ttgaaagcaa
     4441 tgcggattcc ttatataatt cttgattcaa atgagaatga tgcatttatt cagctccatg
     4501 atatcataca atcagcaaaa actaagaata ttcctcatgc aataattatt cggaaagatg
     4561 tttttggcaa atataaactt caaaaagagt tcggatgtaa ttatccttta tctcgtgagg
     4621 atgctttgca aatagttgtg gattatctgc ctgaaaattc agtggtcgtt tctactactg
     4681 gcaagctttc tcgtgagtta tttgaatatc gagaaatgaa agagcaaggt catgaacatg
     4741 attttctcac ggtaggctct atgggacata gttcatcaat ctctttgggt attgctatag
     4801 caaagcaaga tagacctgtt tattgcttgg atggtgatgg agcatttatt atgcatttag
     4861 gggcaattag taacattggc gatttatctc ctaaaaacta ttatcatatt ttgtttaaca
     4921 atggtgctca cgagtctgta ggaggacagc ctactttagg atttagttta gatattccgg
     4981 ctattgtccg ggggagcgga tataagcata cttatactgt ttgtacaaaa gttgaaattg
     5041 aagaagcaat gaagcagctt ccaaagttat gtggtcctgt tttgttggaa ataaaggtta
     5101 aaatagattc tcgggagaat ttgggacgtc ccacgactac tcctatagag aataaggagc
     5161 attttatgga ttttttaaaa taaatatatt cgatgaaaat agaaagaaaa atattattaa
     5221 atcctgggcc tgccactact actgacagtg taaaaatggc acaagttgtt ccggatattt
     5281 gtcctcgcga gaaagaattc gcaggtatga tgaaacaact tcgggacgat ttggtcagag
     5341 ttgctcatgg gaatttggaa aaacataccg ctgtattatt ttgtggctca ggaaccatca
     5401 atattgatat atgtctaaat tctcttcttc ctgaagacaa aagggtgctt atagtgaata
     5461 atggggcata tagtacccgt gctgtagaag tgtgtcaata ttatggtttg cctcatatta
     5521 atttggaatt ttccgtttac gaacgtcctg atttatcggt ggtggaaaat gtgttgcaag
     5581 aaaatcctga tatagctatg gtttatacta ctcatcacga gacgggtaca ggaattctga
     5641 accctattcg cgagatgggc gctatagctc ataaatatca ggctaaattt gtcgtcgata
     5701 ctacttcttc tttgggcatg attccttttg atatagagaa agataatgtg gatttttgta
     5761 tggcatctgc tcaaaaagga cttcaagcga tgacaggtct ttcttttatt ataggcaatg
     5821 aggaacagat taagttttca aaaaaatatc ccaagcgttc ttactattgt aatctttatt
     5881 tgcagtatga gaattttgag agaacaggtg aaatgcattt tactccaccg gtacaaacta
     5941 tttacgccac tcgtcaggca ttaaatgaat attttgaagt gggtgaagaa gctaagtttg
     6001 cccgtcacaa aagagttttt gaggctattc attcaggtat aaatgaaatt ggtcttaaaa
     6061 gtgtaataaa gcgtgaatgg cagtcaggac tggttgtctc agttcaatac ccagaagatc
     6121 ccaactggga ttttgagaaa atacatgatt attgttatga gcgtggattt acgatttatc
     6181 caggtaagat atcaactgag gatactttta gaatctgtgc tttaggagag atagaagtag
     6241 atgatattga gaacttcttt aaagtactaa aagctgcatt aaatcattat aacgtcacat
     6301 taccgatgtc atgattgcag aaatattatt gaagattcgt catttttatt tttcccttcg
     6361 tggtatacac ttccatccgg aaagtgttat ttctggagtg cctattcgta gctttcgctt
     6421 agtaggcaaa tatggcaata ttaatttgag gtgatgcatt aggagttctt tattcttata
     6481 aaaaggcatc ggtagttata ggagataatg tttgtgtagg gtaatttgct tttagtggga
     6541 gagaccatat tagaattgcg gtaaggggcg aagaagataa taaccaatta gtgagaatat
     6601 tggaaaaata taattgatat cggtaaatgt agttgttttt atactgtatt taagtaatgg
     6661 aaaatctaaa gcagaaaact gtatcaggaa taatgtggag cgctatagaa cgtttctctt
     6721 tacaaggagt acagtttata attcaaataa tattagctcg tttgttacta ccatcggatt
     6781 atggtatgat cgggatgtta gctatttttc ttcaagtcgc tcaagtattt atagatagcg
     6841 gttttacaaa tgctttaatc cagaaaaaag atagaactga agaggatttt gccactgtct
     6901 tttattttaa tattcttgtc gcagtattat tctatggtat attgtttttt tcggcttctt
     6961 tgattgcaga cttttataat atgccgactt tagttcttgt aattcgtttt atagcattgt
     7021 cgttgataat aaatgcttta tcggctattc acagaacgaa attaattatt tctgtaaact
     7081 ttaaaactca atctaaaatt tcattaggtg cagcttttat atcaggcgtg attggaatat
     7141 ggatggctta tgtcggttgc ggggtttggg ctttagtttg gcaaactctc ttaaatagta
     7201 taattttgac aattttgttt tactgtttag ttcattggaa acctttacat actttctcca
     7261 aaagttcttt tgaaagatta ttcaatttcg gatctaaatt attgatctca agtcttatca
     7321 atacagtata tcgtaatctg tataccattg taataggaaa aaagttttct gttgtagagc
     7381 ttggttacta tacaagagca gaacaatttg ctatttttcc ttccaataat ttaaatgctt
     7441 tagtttctag agtagcgtat cctattttaa gttccattca agatgatgat aaatgtttaa
     7501 caaacgcata tcgaaattat atcagattat cctcatatat aatttttcct ttaatggtag
     7561 gtttacttgt tttggctaat cctattatta gtctattgtt aacagataaa tggtctgggg
     7621 ttgttattct tttacagata ttatgtttgg attggatgtt tgatcatttg agccaaatta
     7681 atttgaattt attatgggtt aaaggaagat ctgatctgtc gttacgtctt gaaataataa
     7741 aaaagacgat tgctatattc attctttttg tgtcaattcc atttgggctt gaggtgatgt
     7801 gttggggtag agttatttac tctctgatag cgacatattt gaatacatat tatactaatt
     7861 ctcttattga tttgacctta aagttgcaag ttaaagatgt atttccaagt ttaatactct
     7921 ctttcataat gggggggatc gtttttatat gtatttcttt ctttgaaact gatatagtaa
     7981 aaattgtgat tggatgtatt actgggatgt ccttctatat tttactttct tttcttttta
     8041 agctagattc ttttttttgt attttaacat tgatcattaa aactaaaaac atagatgaaa
     8101 atattaaaaa agatttttca agtaatagta aagataatta accattgtgt gccagttgat
     8161 agtagatcat tgtattttat tcctcatcct aattgtagaa cagataaata tgatattata
     8221 aattattcgt cagataatgt tctcgttctg ttaaattatt tgctaaaaaa agatagtgct
     8281 gaatattata aaatatatgt tgaaatttat gattcttctc gtatttcaga atatcaagaa
     8341 tatatttatg gcataaatcc taatattagg tgtacttttt tatgtgcatg tgttggacgt
     8401 tttttcttta ataaagtatc ttttaaggat atgttgtatg cctttttttg tttttgtaga
     8461 gcaagtaaat gttttacagc tactttttat tatgattttt catttaaaaa acgctctcaa
     8521 cagattattt gtttggggta ttatactcca ttcaaagatg attatcatat gggagatcat
     8581 tcttatgata aatttcgtaa tacaacatgt aactcatttg attactctat tgctacttct
     8641 tgtttaagtg ctagaataat ttcaatagat tgtggaatct catatgataa attcaaagtc
     8701 ttaggatttc ccagaaatga tttgttgata tcgaaaaata attgcaatgt tattaaaaga
     8761 gaaatttcga aatttgcggg atatgatgta actaaatata tagtttatac tccaactttt
     8821 cgtgattatg agactgttac tgaaggtaat ttgcgttcaa tactcggata tgttgattgt
     8881 gatttgttga agttatcgaa aatactattg aagtttaatg cggctttaat tcttaaatta
     8941 catcctttgc agaataaaac agtcttaaaa aaagatttac ccaaaggtat acttgttttt
     9001 gaacaaacat ataaatatgg attgtatgat cttttgtcat tttcagatgg aatgattact
     9061 gattatactt ctacctattt tgatttttta ttggtaaata agccagtcat atttaatttc
     9121 tacgatattg aagaatatcg tagagtaaga ggtttctcat ttgagccaat agaatttttt
     9181 tgtgcaggtg atattgttta caattataat gaattgatag atgctgtgat gggacttctg
     9241 gctgggaaag atattcatgc tgaacatcga cgtcatattt ctttattgat gaatcaattt
     9301 caagatgata attcaacaaa gagaatatgt gacatatttt taaatgaaat ataataaata
     9361 aaatgaatta tgcatttgtg gtgcaggcac gtttaggttc tacacgtttg cctggaaaaa
     9421 tattgaaacc tttctatggt aatcaatcga ttcttgactt aatggttcat aagctttctg
     9481 ctatatcgaa tattccagta attattgcta caacaaattc tgttatcaat gaacctattg
     9541 aaaagaaggc acttgcatta ggggtaaagt gcttcagagg tgaggagaat gatgttttaa
     9601 aacgattcat tgatgttgct gaatattttg atatacaggg tatattccga atatgttctg
     9661 ataatccatt tttagatgta catgcggcaa ggcaattggt cgaaatagca atgaaatctt
     9721 gtaacgatta tataagtttt gatattgatg gtactccatc aattaaaact catttcggtt
     9781 tttggggaga atttgtaacg cttgatgcgc tgaagcgagt tataggattt actgatgatt
     9841 tattgtatcg tgaacatgtt actaattata tatatagtca tcctgaactt tttaatattc
     9901 aatggatttc aggatctcca gtcgtgtcaa aacatcataa tattcgactc acgattgata
     9961 cgttagaaga tttttctgta gcacagagaa tatataggga tttacaagaa aaaagagtgg
    10021 aaatatcgat agaagtgatt gtagactatg ttcgaagaca tgcagaatac attcaactga
    10081 tgaaacaaca aataaaaaaa aattctaaat aatgaagaat acttatatta ttggtgaaat
    10141 agggcagaat cataatggtt ctgttgactt ggctaagttg attattgaat taatctcacg
    10201 acctgtacat gaggatgttt ttggtatgga tttcatgcca atgaatgctg ttaaaatgac
    10261 taaaagagat ttatcagaag aattggctgt ttctcaaatg aatcaaatat atgacaatcc
    10321 taattctttt gggcgtactt atggtgaaca tcgtgctttt cttgagcttg atgatcaagc
    10381 gcattttgag atttataaat atgctaagtc attaggatta gattttatcg agacgttatg
    10441 tgccaaagga tgtctgtctt tgcttaaact gttcacaccg gataggctaa aagttgctag
    10501 tcgtgatttg actaacttac cattgcttga agcattagca gaaactcata ttcctattat
    10561 attatcgaca ggaatggctg gtcaaagaga acttgacaat gcattagatg tgataacgag
    10621 atatcatagt aatatagcta ttctacattg tgtatctcag tatccaactc atccaaataa
    10681 tttgaatcta cgtacaataa catatttgaa gaagcattac aataagtttg agataggttt
    10741 ttctgatcat acaataggta tttctgctgc tacagctgct gtagcgatgg gagcggaaat
    10801 tatagaaaag catgtaacaa ttgatcggca tatgaaagga acagaccagc ttggctcttt
    10861 aggtccagat ggggttaatc gtatgattcg agatattcgc atagcagagt gttggcttgg
    10921 tactgaagat ctttatatag aaaaaggggt ggagaagtct aagataaaac ttgaacgttc
    10981 tattgccact cgaaaatata ttccagcagg tagtattatt caagagtcgg acattcattt
    11041 actgagtcct ggtgatggtt ataaatggat agataaaaaa aatgtaattg gtcattttgc
    11101 taaacaagat atatcagcga atgaaataat atatcctgat tttattgaat agatatattc
    11161 ctactgcaac ttgtattacg gtatagagta ctgcctgcta taagctaagt agtgattaat
    11221 aaataagggt aaaatactaa aaaaatgaaa gagataaagc ttatacttac agatattgat
    11281 ggcgtttgga ctgatggcgg aatgttttat gatc
//
